CN104984305B - A kind of Chinese medicine composition for treating chronic cholecystitis - Google Patents
A kind of Chinese medicine composition for treating chronic cholecystitis Download PDFInfo
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Abstract
The invention discloses a kind of Chinese medicine compositions for treating chronic cholecystitis, belong to the technical field of the drug for the treatment of chronic cholecystitis.The Chinese medicine composition of the present invention includes the raw material of following parts by weight：12 18 parts of rhizoma zingiberis, 10 15 parts of radix scutellariae, 10 15 parts of radix bupleuri, 8 12 parts of the tuber of pinellia, 12 18 parts of Radix Codonopsis, 10 15 parts of Cortex Magnoliae Officinalis, 10 15 parts of turmeric, 10 15 parts of Radix Curcumae, 10 15 parts of the dried immature fruit of citron orange, 10 15 parts of Radix Paeoniae Alba, 8 12 parts of jujube, 8 12 parts of Radix Glycyrrhizae.The present invention is selected from natural traditional Chinese medicine raw material, and compatibility is scientific and reasonable, and drug effect complements each other, and brings out the best in each other, and has effects that the inverse heat-clearing of warm stomach invigorating the spleen, drop, qi and activate blood circulation, disperse accumulation resolving sputum and blood-activating analgetic, lesion depths of going directly；The microcirculation of human body can also be improved, immunity of organisms is improved, treating both manifestation and root cause of disease has been achieved the purpose that the treatment of chronic cholecystitis；Its mild easily clothes, has no adverse reaction, good effect, cure rate is high, does not recur.
Description
Technical field
The invention belongs to treating the technical field of the drug of chronic cholecystitis, a kind of chronic cholecystitis for the treatment of is particularly related to
Chinese medicine composition.
Background technology
Chronic cholecystitis（chronic cholecystitis）It is clinically common disease, frequently-occurring disease, means gall-bladder chronic inflammation
Disease venereal disease becomes, and is mostly chronic lithogenous cholecystitis, accounts for 85%~95%, minority is non-calculous cholecystitis, such as typhoid carrier.
It, also can chronic onset from this disease can be delayed by acute cholecystitis recurrent exerbation.Clinical manifestation is without specificity, it can be common that upper right
Abdomen or precordial region secret anguish, glutted discomfort after food, belch can have nausea after feeding greasy food, occasionally there is vomiting.In the elderly,
Silent gallbladder can be claimed scorching without clinical symptoms.
Currently, the method key agents treatment for the treatment of chronic cholecystitis and operative treatment, drug therapy is mainly anti-inflammatory profit
The method of courage, such as XIAOYAN LIDAN PIAN, livonal, Trepibutone, Hymecromone, neocholan and ursodesoxycholic acid, some patients have
Effect, but high recurrence rate, therapeutic effect is undesirable, and patient has to prolonged administration of drugs maintenance, moreover, easy ting produce drug resistance；
Operative treatment cholecystitis is one of most common operation of current abdominal surgery, but there is also drawbacks, i.e. wound for operative treatment
Greatly, postoperative to easy to produce complication, long-term effect is nor highly desirable；With the development of lunar physics technique, also occur much controlling
The Chinese patent drug of chronic cholecystitis is treated, has side effect after these drug administrations, though the pain of cholecystitis can be alleviated, often occurs
The adverse reactions such as the gasteremphraxis that has a stomach-ache.
Invention content
The present invention provides a kind of Chinese medicine composition for treating chronic cholecystitis, solves and treats chronic gall-bladder in the prior art
The problem of scorching curative effect of medication is poor, side effect is big and high recurrence rate.
A kind of Chinese medicine composition for treating chronic cholecystitis of the present invention, is mainly subject to reality by the following technical programs
Existing：The Chinese medicine composition includes the raw material of following parts by weight：12-18 parts of rhizoma zingiberis, 10-15 parts of radix scutellariae, 10-15 parts of radix bupleuri,
8-12 parts of the tuber of pinellia, 12-18 parts of Radix Codonopsis, 10-15 parts of Cortex Magnoliae Officinalis, 10-15 parts of turmeric, 10-15 parts of Radix Curcumae, 10-15 parts of the dried immature fruit of citron orange, Radix Paeoniae Alba
10-15 parts, 8-12 parts of jujube, 8-12 parts of Radix Glycyrrhizae.
In the Chinese medicine composition of the present invention, rhizoma zingiberis：Acrid flavour, property heat；Returns spleen, stomach, the heart, lung channel；With warming spleen and stomach for dispelling cold, Hui Yang
Promote blood circulation, eliminating dampness dissolving phlegm, warming lung and resolving fluid the effect of；Coldness and pain in the epigastrium is cured mainly, is vomitted, diarrhea, yang depletion is fainted inverse, and cold drink is breathed with cough, cold-dampness numbness
Bitterly.
In the Chinese medicine composition of the present invention, radix scutellariae：Sweet in flavor, tepor；Returns spleen, lung channel；With invigorating qi for consolidating superficies, tonifying Qi and lifting yang,
The effect of promoting pus discharge and tissue regeneration, inducing diuresis for removing edema；Cure mainly treatment deficiency of vital energy weak, anorexia and loose stool, the sinking of qi of middle-jiao, rush down prolapse of the anus for a long time, spontaneous sweating, the deficiency of blood
Sallow, cloudy subcutaneous ulcer is unrestrained swollen, qi deficiency edema, Heat Diabetes.
In the Chinese medicine composition of the present invention, radix bupleuri：The pungent, bitter of property is slightly cold；Return liver, courage, lung channel；With in inducing diaphoresis, dredge
Liver solution is strongly fragrant, yang invigorating, bring down a fever preventing malaria the effect of；Cold, fever is cured mainly, fevers and chills alternate, distending pain in the chest and hypochondrium, irregular menstruation, uterus takes off
It hangs down, rectal prolapse.
In the Chinese medicine composition of the present invention, the tuber of pinellia：It is acrid flavour, warm-natured；Returns spleen, stomach；With eliminating dampness and eliminating phlegm, stopping nausea and vomiting by lowering the adverse flow of QI,
The effect of dissolving lump and resolving mass；Cure mainly hot phlegm, vomiting, wind phlegm.
In the Chinese medicine composition of the present invention, Radix Codonopsis：It is sweet in flavor, it is mild-natured；Returns spleen, lung channel；Moisten gas with matter and there is invigorating the spleen benefit
Lung, nourishing qi and blood, the effect of promoting the production of body fluid；Weakness of the spleen and the stomach, anorexia and loose stool, lassitude hypodynamia are cured mainly, the deficiency syndrome of the lung is breathed with cough, shortness of breath lazyness speech, spontaneous perspiration,
Blood deficiency chlorosis, it is thirsty.
In the Chinese medicine composition of the present invention, Cortex Magnoliae Officinalis：Bitter, property is pungent, tepor；Returns spleen, stomach, large intestine channel；With gas consumption product,
The effect of eliminating dampness except full, relieving asthma；Cure mainly stagnation of QI due to dyspepsia, abdominal distention constipation, damp retention in middle-jiao, abdominal swelling and diarrhea, phlegm stops up the circulation of vital energy in the wrong direction, fullness sensation in chest
It breathes with cough.
In the Chinese medicine composition of the present invention, turmeric：Bitter, property is pungent, tepor；Returns spleen, Liver Channel；With promoting the circulation of qi broken stasis of blood, promoting menstruation
The effect of analgesic；Cure mainly chest and abdomen swelling and pain, shoulder arm numbness pain, irregular menstruation, amenorrhoea, traumatic injury.
In the Chinese medicine composition of the present invention, Radix Curcumae：Acrid flavour, property are bitter, are slightly cold；Return liver, the heart, lung channel；With regulating qi to disperse stagnation, clearly
Heart solution is strongly fragrant, normalizing gallbladder to cure jaundice, promoting blood circulation and stopping pain, promoting qi circulation and removing obstruction in the collateral, the cool blood that clears away heart-fire the effect of；Cure mainly all pains of chest and abdomen side of body rib, insane, heat
Sick coma is spitted blood, bleeding from five sense organs or subcutaneous tissue, hematuria, blood strangury, women's vicarious menstruation, jaundice.
In the Chinese medicine composition of the present invention, the dried immature fruit of citron orange：Bitter, property is pungent, is slightly cold；Returns spleen, stomach, liver, the heart channel of Hang-Shaoyin；Disappear with promoting the circulation of qi
The effect of ruffian, disperse accumulation resolving sputum；Internal stagnation is cured mainly, feeling of fullness distending pain, constipation, weight after rush down dysentery, accumulation of pathogens in chest, gastroptosis, uterus takes off
It hangs down, rectal prolapse.
In the Chinese medicine composition of the present invention, Radix Paeoniae Alba：Property is bitter, sour, is slightly cold；Return liver, the spleen channel；The moon, soft liver are held back with blood-nourishing
The effect of analgesic, suppressing liver-YANG；Cure mainly liver-blood deficiency and deficiency of blood irregular menstruation, the chest side of body epigastric pain or four limbs contraction of incoordination between the liver and the spleen
Anxious pain, the dizziness of having a headache of liver-yang hyperactivity.
In the Chinese medicine composition of the present invention, jujube：It is sweet in flavor, it is warm-natured；Returns spleen, stomach；With tonifying middle-Jiao and Qi, nourishing blood and tranquilization
Effect；Cure mainly spleen eating less, weak loose stool, hysteria of womam.
In the Chinese medicine composition of the present invention, Radix Glycyrrhizae：It is sweet in flavor, it is mild-natured；Returns spleen, stomach, lung channel；With invigorating the spleen and benefiting qi, emergency is stopped
Bitterly, the effect of taste cough moistening lung, emergency is detoxified；Burnout deficiency of food is cured mainly, the thin face of flesh is yellow, palpitation, abdominal pain loose stool, and four limbs contraction is suddenly ached
Bitterly, hysteria, cough gather asthma, abscess of throat, ulcerative carbuncle swelling and pain；For weakness of the spleen and the stomach, lassitude hypodynamia, palpitation, coughing with a lot of sputum, gastral cavity
Abdomen, four limbs contraction, carbuncle sore tumefacting virus alleviate drug toxicity, strong.
The Chinese medicine composition of the present invention, the Chinese medicine composition further includes the raw material of following parts by weight：10-15 parts of green peel,
8-12 parts of 10-15 parts of root of Aucklandia lappa Decne, 10-15 parts of radix paeoniae rubra, giant knotweed or felwort, Hu 12-18 parts profound, 8-12 parts of Fructus meliae toosendan, malt 12-18
Part, 8-12 parts of rheum officinale, 8-12 parts of hare's-lettuce.
In the Chinese medicine composition of the present invention, green peel：Toil, tepor；Return liver, gallbladder channel；With soothing the liver relieving stagnant Qi, dissipating bind dissolving phlegm
Effect cures mainly chest side of body gastral cavity pain, and hernia, dyspepsia, breast is swollen, newborn core, chronic malaria addiction block.
In the Chinese medicine composition of the present invention, root of Aucklandia lappa Decne：Bitter, property be pungent, tepor；Returns spleen, stomach, liver and large intestine channel；With promoting the circulation of qi
Analgesic leads stagnant effect in adjusting；It cures mainly born of the same parents and coerces weight after turgor foot, abdominal distention, vomiting and diarrhea, dysentery.
In the Chinese medicine composition of the present invention, radix paeoniae rubra：Bitter, property acid, is slightly cold；Return liver warp；With clearing heat and cooling blood, promoting blood circulationization
The effect of stasis of blood, analgesic；Cure mainly blood-heat bleeding, hematemesis macular eruption, blood stasis closed, traumatic injury, pathopyretic ulcer, irascibility hot eyes.
In the Chinese medicine composition of the present invention, giant knotweed：Slight bitter is slightly cold；Return liver, courage, lung channel；With clearing heat and detoxicating, cholagogic moves back
Huang, expelling wind and removing dampness, scattered stasis pain, relieving cough and reducing sputum effect；Cure mainly joint pain, jaundice with damp-heat pathogen, Amenorrhea , wei lumps in the abdomen, coughing with a lot of sputum,
Scald, injury from falling down, carbuncle sore tumefacting virus.
In the Chinese medicine composition of the present invention, felwort：Bitter, it is cold in nature；Return liver, gallbladder channel；With heat-clearing and damp-drying drug, purging the liver of pathogenic fire courage fire
The effect of；Jaundice with damp-heat pathogen is cured mainly, swelling of vulva pruritus vulvae, under, persistent erection, eczema itch, hot eyes is deaf, hypochondriac pain, bitter taste, convulsion.
In the Chinese medicine composition of the present invention, profound Hu：The pungent, bitter of property, tepor；The thoughts of returning home, liver, spleen, lung channel；With promoting blood circulation, dissipate
The effect of stasis of blood, qi-regulating, analgesic；Cure mainly all pains of trusted subordinate's waist and knee, irregular menstruation, abdominal mass, metrorrhagia, postpartum anemic fainting, lochiorrhagia, bruise
Damage and chest side of body, epigastric pain, closed dysmenorrhea, postpartum stasis, the symptoms such as tumbling and swelling.
In the Chinese medicine composition of the present invention, Fructus meliae toosendan：Bitter, it is cold in nature, it is slightly poisonous；Return liver, small intestine, bladder warp；With easypro
The effect of liver promoting qi circulation and relieving pain, expelling parasite；Cure mainly chest side of body, abdominal distention, colic, abdominal pain due to enterositosis.
In the Chinese medicine composition of the present invention, malt：It is sweet in flavor, it is mild-natured；Returns spleen, stomach；With promoting the circulation of qi helps digestion, spleen benefiting and stimulating the appetite,
The effect of moves back newborn dissipate-swelling；Cure mainly dyspepsia, abdominal distention, spleen eating less, milk smoulders, swollen breasts, women weans.
In the Chinese medicine composition of the present invention, rheum officinale：Bitter, it is cold in nature；Return stomach, large intestine, liver, the spleen channel；With heat and toxic materials clearing away, rush down
Fiery removing toxic substances, lets out clearly damp and hot effect at promoting blood circulation；Cure mainly real heat constipation, accumulation of heat in chest ruffian, damp-heat dysentery, jaundice, gonorrhoea, oedema
Abdomen is full, difficult urination, hot eyes, abscess of throat, aphthae, gastropyretic vomiting, spits blood, and spitting of blood, bleeding from five sense organs or subcutaneous tissue is had blood in stool, hematuria, stores blood,
Amenorrhea, postpartum stasis of blood, a lump in the abdomen causing distension and pain, traumatic injury, heat toxin large carbuncle, erysipelas, scald.
In the Chinese medicine composition of the present invention, hare's-lettuce：Bitter, it is cold in nature；Return liver, lung channel；With clearing heat and detoxicating effect；It cures mainly
Jaundice, gastritis, dysentery, cough with lung heat, carbuncle swells, impetigo, intestines production is swollen, orchitis, close sore.
Specifically, Chinese medicine composition of the invention, the Chinese medicine composition include the raw material of following parts by weight：Rhizoma zingiberis 15
Part, 12 parts of radix scutellariae, 12 parts of radix bupleuri, 9 parts of the tuber of pinellia, 15 parts of Radix Codonopsis, 12 parts of Cortex Magnoliae Officinalis, 12 parts of turmeric, 12 parts of Radix Curcumae, 12 parts of the dried immature fruit of citron orange, in vain
12 parts of Chinese herbaceous peony, 10 parts of jujube, 9 parts of Radix Glycyrrhizae.
The present invention is middle benefit gas cholagogic side, and it is monarch drug in a prescription that rhizoma zingiberis is reused in side, and warm stomach invigorating the spleen is dropped admittedly defending middle-jiao yang, function of the spleen and stomach with the ministerial drug tuber of pinellia
Inverse and stomach, pungent to open bitter drop, radix bupleuri, radix scutellariae conciliate heat-clearing, and to remove the heresy of few sun, Radix Codonopsis warming middle-JIAO and strengthening the spleen QI invigorating is helped with Cortex Magnoliae Officinalis, the dried immature fruit of citron orange
Middle benefit gas promoting the circulation of qi, disperse accumulation resolving sputum, turmeric, Radix Curcumae promoting blood circulation, removing blood stasis and relieving pain, the soft protecting liver of Radix Paeoniae Alba, relieving spasm to stop pain, Radix Glycyrrhizae, jujube solid protection stomach
Gas, coordinating the drug actions of a prescription.
Preferably, the Chinese medicine composition further includes the raw material of following parts by weight：12 parts of green peel, 12 parts of root of Aucklandia lappa Decne, radix paeoniae rubra 12
Part, giant knotweed or 9 parts of felwort, 15 parts of profound Hu, 10 parts of Fructus meliae toosendan, 15 parts of malt, 9 parts of rheum officinale, 9 parts of hare's-lettuce.
Each taste Chinese herbal medicine compatibility of the present invention is scientific and reasonable, and drug effect complements each other, and brings out the best in each other；Add green peel and root of Aucklandia lappa Decne with row
Gas adds radix paeoniae rubra to invigorate blood circulation, and adds giant knotweed or felwort clearing damp antipyretic, and profound Hu and Fructus meliae toosendan dispersing the depressed liver-qi and alleviating pain, malt promoting the circulation of qi helps digestion is added to add
Rheum officinale heat and toxic materials clearing away, and it is clearing heat and detoxicating to be equipped with hare's-lettuce.
Further, the dosage form of the Chinese medicine composition is granule, pill, oral solution, capsule or tablet.The present invention's
Dosage form diversification, preparation process is simple, at low cost, can be convenient to take according to actually being selected, and different crowds is suitble to need
It wants.
The usage of the Chinese medicine composition of the present invention：The Chinese medicine composition of the present invention, 2 times a day, each 2g, 1 week is 1 treatment
Journey, the 1-3 course for the treatment of can cure.
Beneficial effects of the present invention：The Chinese medicine composition of the present invention is selected from natural traditional Chinese medicine raw material, each taste Chinese herbal medicine compatibility section
It is reasonable to learn, and drug effect complements each other, and brings out the best in each other, and there is warm stomach invigorating the spleen, the inverse heat-clearing of drop, qi and activate blood circulation, disperse accumulation resolving sputum and stagnation resolvation to stop
The effect of pain, lesion depths of going directly, pair simultaneously chronic cholecystitis progress essence treatment；It is followed at the same time it can also improve the micro- of human body
Ring improves immunity of organisms, to achieve the purpose that treating both manifestation and root cause of disease.Simplicity is prepared, medicine source is wide, at low cost, and dosage is few；Together
When, mild in medicine property and taste it is moderate, without bitter taste, mild easily clothes, it is substantially non-stimulated to stomach, have no toxic and side effect to human body,
Without drug dependence, economy and the psychological burden of patient are greatly reduced.Theory of traditional Chinese medical science is followed, dialectical to treat, symptom eliminates are fast,
Adverse reaction is not found after medication, good effect, cure rate is high, has for the treatment of chronic cholecystitis and its complication significant
Curative effect.
Specific implementation mode
Technical scheme of the present invention is clearly and completely described below in conjunction with specific embodiment, it is clear that described
Embodiment be only a part of the embodiment of the present invention, instead of all the embodiments.Based on the embodiments of the present invention, ability
The every other embodiment that domain those of ordinary skill is obtained without creative efforts, belongs to guarantor of the present invention
The range of shield.
A kind of Chinese medicine composition for treating chronic cholecystitis, Chinese medicine composition include the raw material of following parts by weight：Rhizoma zingiberis 12-
18 parts, 10-15 parts of radix scutellariae, 10-15 parts of radix bupleuri, 8-12 parts of the tuber of pinellia, 12-18 parts of Radix Codonopsis, 10-15 parts of Cortex Magnoliae Officinalis, 10-15 parts of turmeric,
10-15 parts of Radix Curcumae, 10-15 parts of the dried immature fruit of citron orange, 10-15 parts of Radix Paeoniae Alba, 8-12 parts of jujube, 8-12 parts of Radix Glycyrrhizae.
Further, Chinese medicine composition of the invention, Chinese medicine composition further include the raw material of following parts by weight：Green peel 10-
8-12 parts of 15 parts, 10-15 parts of root of Aucklandia lappa Decne, 10-15 parts of radix paeoniae rubra, giant knotweed or felwort, Hu 12-18 parts profound, 8-12 parts of Fructus meliae toosendan, malt
12-18 parts, 8-12 parts of rheum officinale, 8-12 parts of hare's-lettuce.
Specifically, Chinese medicine composition of the invention, Chinese medicine composition include the raw material of following parts by weight：15 parts of rhizoma zingiberis, Huang
12 parts of a kind of reed mentioned in ancient books, 12 parts of radix bupleuri, 9 parts of the tuber of pinellia, 15 parts of Radix Codonopsis, 12 parts of Cortex Magnoliae Officinalis, 12 parts of turmeric, 12 parts of Radix Curcumae, 12 parts of the dried immature fruit of citron orange, Radix Paeoniae Alba 12
Part, 10 parts of jujube, 9 parts of Radix Glycyrrhizae.
Further, Chinese medicine composition of the invention, Chinese medicine composition further include the raw material of following parts by weight：Green peel 12
Part, 12 parts of root of Aucklandia lappa Decne, 12 parts of radix paeoniae rubra, giant knotweed or 9 parts of felwort, 15 parts of profound Hu, 10 parts of Fructus meliae toosendan, 15 parts of malt, 9 parts of rheum officinale, hardship
9 parts of lettuce.
More specifically, the dosage form of Chinese medicine composition is granule, pill, oral solution, capsule or tablet.
Embodiment one
A kind of Chinese medicine composition for treating chronic cholecystitis of the present invention, which includes the original of following parts by weight
Material：Rhizoma zingiberis 12g, radix scutellariae 10g, radix bupleuri 10g, tuber of pinellia 8g, Radix Codonopsis 12g, Cortex Magnoliae Officinalis 10g, turmeric 10g, Radix Curcumae 10g, dried immature fruit of citron orange 10g, in vain
Chinese herbaceous peony 10g, jujube 8g, Radix Glycyrrhizae 8g.
Above-mentioned raw materials to be added into water, are impregnated, are distilled, are concentrated, spray drying is made granule, often packs 1g, every time 2 packet,
2 times a day, one week for a course for the treatment of, the 1-3 course for the treatment of can cure.
Embodiment two
A kind of Chinese medicine composition for treating chronic cholecystitis, Chinese medicine composition include the raw material of following parts by weight：Rhizoma zingiberis
18g, radix scutellariae 15g, radix bupleuri 15g, tuber of pinellia 12g, Radix Codonopsis 18g, Cortex Magnoliae Officinalis 15g, turmeric 15g, Radix Curcumae 15g, dried immature fruit of citron orange 15g, Radix Paeoniae Alba 15g,
Jujube 12g, Radix Glycyrrhizae 12g.
Above-mentioned raw materials are crushed, are sieved, is uniformly mixed, pill is made, are 3g per ball weight, each taking 2 balls, daily 2
Secondary, one week for a course for the treatment of, the 1-3 course for the treatment of can cure.
Embodiment three
A kind of Chinese medicine composition for treating chronic cholecystitis, Chinese medicine composition include the raw material of following parts by weight：Rhizoma zingiberis
15g, radix scutellariae 12g, radix bupleuri 12g, tuber of pinellia 9g, Radix Codonopsis 15g, Cortex Magnoliae Officinalis 12g, turmeric 12g, Radix Curcumae 12g, dried immature fruit of citron orange 12g, Radix Paeoniae Alba 12g, greatly
Jujube 10g, Radix Glycyrrhizae 9g.
1000mL water is added in above-mentioned raw materials, is decocted, and is boiled after 30min, is poured out decoction liquor；Remaining filter residue is continued
It adds water to cook, decocts 3 times altogether；Decoction liquor is merged, 100mL is concentrated into；It is divided into twice, respectively takes 50mL sooner or later, 1 week is 1
A course for the treatment of, the 1-3 course for the treatment of can cure.
Example IV
A kind of Chinese medicine composition for treating chronic cholecystitis of the present invention, Chinese medicine composition includes the original of following parts by weight
Material：Rhizoma zingiberis 12g, radix scutellariae 10g, radix bupleuri 10g, tuber of pinellia 8g, Radix Codonopsis 12g, Cortex Magnoliae Officinalis 10g, turmeric 10g, Radix Curcumae 10g, dried immature fruit of citron orange 10g, in vain
Chinese herbaceous peony 10g, jujube 8g, Radix Glycyrrhizae 8g, green peel 10g, root of Aucklandia lappa Decne 10g, radix paeoniae rubra 10g, giant knotweed or felwort 8g, profound Hu 12g, Fructus meliae toosendan 8g,
Malt 12g, rheum officinale 8g, hare's-lettuce 8g.
Above-mentioned raw materials are impregnated, are distilled, are concentrated, it is dry, it is packed into capsule, is made capsule, every capsule weight 0.50g, often
Secondary to take 4,2 times a day, one week for a course for the treatment of, the 1-3 course for the treatment of can cure.
Embodiment five
A kind of Chinese medicine composition for treating chronic cholecystitis, Chinese medicine composition include the raw material of following parts by weight：Rhizoma zingiberis
18g, radix scutellariae 15g, radix bupleuri 15g, tuber of pinellia 12g, Radix Codonopsis 18g, Cortex Magnoliae Officinalis 15g, turmeric 15g, Radix Curcumae 15g, dried immature fruit of citron orange 15g, Radix Paeoniae Alba 15g,
Jujube 12g, Radix Glycyrrhizae 12g, green peel 15g, root of Aucklandia lappa Decne 15g, radix paeoniae rubra 15g, giant knotweed or felwort 12g, profound Hu 18g, Fructus meliae toosendan 12g, wheat
Bud 18g, rheum officinale 12g, hare's-lettuce 12g.
Above-mentioned raw materials are impregnated, are distilled, are concentrated, are dried, tabletting, tablet is made, every weighs 1g, each taking 2, daily
2 times, one week for a course for the treatment of, the 1-3 course for the treatment of can cure.
Embodiment six
A kind of Chinese medicine composition for treating chronic cholecystitis, Chinese medicine composition include the raw material of following parts by weight：Rhizoma zingiberis
15g, radix scutellariae 12g, radix bupleuri 12g, tuber of pinellia 9g, Radix Codonopsis 15g, Cortex Magnoliae Officinalis 12g, turmeric 12g, Radix Curcumae 12g, dried immature fruit of citron orange 12g, Radix Paeoniae Alba 12g, greatly
Jujube 10g, Radix Glycyrrhizae 9g, green peel 12g, root of Aucklandia lappa Decne 12g, radix paeoniae rubra 12g, giant knotweed or felwort 9g, profound Hu 15g, Fructus meliae toosendan 10g, malt
15g, rheum officinale 9g, hare's-lettuce 9g.
Above-mentioned raw materials to be added into water, are impregnated, are distilled, pill is made in concentration, the weight 1g per ball, every time 2 ball, 2 times a day, 1 week
For 1 course for the treatment of, the 1-3 course for the treatment of can cure.
With reference to specific test example, the present invention is further explained, wherein the animal of the Chinese medicine composition including the present invention
Toxicity test, pharmacodynamics test and clinical observation experiment.
Animal toxicity test
The Chinese medicine composition that the embodiment of the present invention one is arrived to embodiment six, has carried out multiple animal toxicity test respectively, wraps
Include the experiment under Various Seasonal and different geographical；Under the conditions of each season and Different climate, the north, south, the east of such as China
Portion and western part are tested respectively；Every time when experiment, rabbit 20, male and female dual-purpose, weight 2.0-2.3Kg is taken to be divided into two groups, often
Group 10, one of which are overdose test group, and another group is normal amount test group, and overdose test group dosage is 6.0g/kg,
Normal amount test group dosage is 2.0g/kg, and administering mode is that administration by gavage administration once in the morning and once at night continuously takes 10 days, often
Its observation administration reaction；Test of many times the result shows that, two groups of rabbit spirit, activity, diet, drain it is normal；Dissect, naked eyes
Examine main inside internal organs, no abnormality seen；Therefore, the Chinese medicine composition is without bad toxic side effect.
Animal pharmacodynamics test
Effect of the Chinese medicine composition of the present invention to chronic cholecystitis Rabbits Models.
Method：It is the Japan large ear rabbit 90 of 2.0-2.3Kg to take weight, and half male and half female is randomly divided into 9 groups, every group 10
Only, respectively the embodiment of the present invention one arrives the administration group of embodiment six, the Chinese medicine administration group of certain commercially available treatment chronic cholecystitis, mould
Type group and control group；Gastric infusion, one time a day, continuous 5 days；First normal white cell value in measurement animal blood before experiment, medicine feed the
6 days with chloraldurate by family's rabbit anesthesia, abdomen disinfection is open at abdomen median line xiphoid-process, gall-bladder is found after exposure liver, with hoping tweezer
Gall-bladder bottom is picked up, and is 0.3 × 10 picking up place's implantation concentration6The Escherichia coli bacteria liquid of a/mL, 0.1mL/ is only.It fastens into needle
Mouthful, successively disinfection, skin suture, cholecystitis model is caused with this.Continue administration 7 days after modeling, one time a day.In the postoperative 8th
It, ear vein takes blood, detects leukocyte count；Serum is detached, glutamic-pyruvic transaminase is detected（ALT）；It cuts open the belly, gall-bladder is taken to observe calculus shape
At situation；Bile is extracted, the red rope of total courage, total cholesterol, calcium content in bile are surveyed；Test result indicates with means standard deviation,
The conspicuousness for detecting its difference, test result is examined to be included in table 1-3 respectively with t.
The influence result of WBC and ALT contents in 1 cholecystitis and cholelithiasis Rabbits Models blood of table
Remarks：Compared with blank group, +++ --- P<0.001 ,+--- P<0.05；Compared with model group, * * --- P<
0.01, * --- P<0.05.
As can be seen from Table 1, Chinese medicine composition of the invention can significantly reduce leucocyte in cholecystitis infection animal blood
Number has pole significant difference compared with model group；The Chinese medicine composition of the present invention can also be substantially reduced in rabbit anteserum
ALT contents have significant difference compared with model group, show that the Chinese medicine composition of the present invention has liver protection；This
The Chinese medicine administration group of certain more commercially available treatment chronic cholecystitis has more advantage.
The influence result of 2 cholecystitis and cholelithiasis Rabbits Models Cheng Shi of table
Remarks：Compared with blank group, +++ --- P<0.001, ++ --- P<0.01；Compared with model group, * * --- P<
0.01, * --- P<0.05.
As can be seen from Table 2, the Chinese medicine composition of the embodiment of the present invention one to embodiment six can dramatically increase model man
The bile volume of rabbit reduces calculus weight, inhibits the formation of calculus；With the Chinese medicine administration group of certain commercially available treatment chronic cholecystitis
（Commercially available medicine group）It compares, Chinese medicine composition of the invention is more advantageous.
The influence result of total bilirubin, total cholesterol and calcium content in 3 cholecystitis and cholelithiasis Rabbits Models bile of table
Remarks：Compared with blank group, +++ --- P<0.001, ++ --- P<0.01 ,+--- P<0.05；With model group phase
Than * * * --- P<0.001, * * --- P<0.01, * --- P<0.05.
As can be seen from Table 3, the Chinese medicine composition of the embodiment of the present invention one to embodiment six can significantly reduce model man
Total bilirubin, total cholesterol and calcium content in lapin bile can effectively prevent the generation of cholecystitis and the formation of gall stone；This is compared with city
The Chinese medicine administration group for selling certain treatment chronic cholecystitis has more advantage.
Clinical observation experiment
Patient data
Patient 700, wherein man 300, female 400 are diagnosed as chronic cholecystitis, and 23 years old of age minimum, the age was most
Big 60 years old, average age 39.4 years old, the course of disease 1 year to 30 years, average course of disease 16.7, according to male to female ratio, ratio of age and
The method of course of disease balanced proportion is divided into seven groups, a respectively control group and six treatment groups, is not counted between seven groups of patients
Otherness on.This seven groups of patients once use the therapies such as Western medicine or Chinese medicine before receiving this treatment, still, effect
Fruit is not notable, easily recurs, cannot remove root.
Diagnostic criteria
All patients exclude other organic diseases, meet the diagnostic criteria of chronic cholecystitis.
All patients have different degrees of right Upper abdominal pain uncomfortable, and right shoulder carries on the back radiated pain, detest that greasy, feed is greasy
Exacerbation of symptoms after food, the symptoms such as bitter taste, dry throat.
Case exclusion criteria
1. medication skin allergy person；
2. patient mismatches treatment, cannot drug user on time；
3. concurrent other seriously diseases person.
Therapeutic scheme
Control group：Patient takes Chinese medicine of certain commercially available treatment chronic cholecystitis orally, is decoction, one after each meal, one day two
Secondary, each 50mL, 1 month is 1 course for the treatment of, is continuously taken 3 course for the treatment of；
Treatment group：Patient takes the embodiment of the present invention one orally to six kinds of Chinese medicine compositions of embodiment six, and twice a day, 1 week is 1
A course for the treatment of, continuously takes 3 course for the treatment of.
Daily follow-up is primary, is evaluated respectively before medication and after medication, after treatment finishes, continues follow-up 1 year, treatment
Before, further consultation and when follow-up fill in case report form.
All subjects must not merge the drug using any other treatment chronic cholecystitis during experiment and may
Influence the drug of clinical efficacy and adverse reaction evaluation.
The standard of curative effect evaluation
Reference《New Chinese medicine guideline of clinical investigations》（It is tentative）It formulates.
It cures：Clinical symptoms and sign disappear, and ultrasound diagnosis gall-bladder is normal；
It is effective：Clinical symptoms and sign are substantially reduced, and ultrasound diagnosis gallbladder inflammation is substantially reduced；
Effectively：Clinical symptoms and sign take a favorable turn, and attack times are reduced；
In vain：Clinical symptoms and sign, no changes have been made for ultrasound diagnosis.
Therapeutic effect
According to above-mentioned the standard of curative effect evaluation, the treatment results of above seven groups of Clinical Treatment Test personnel are counted,
Summarized results is as shown in table 4.
4 clinical treatment outcome summary sheet of table
Clinical observation result
Above-mentioned Clinical observation the result shows that, of the invention six kinds of Chinese medicine compositions to treatment chronic cholecystitis all have
Fine curative effect, clearly, cure rate is significantly raised for advantage, and inefficiency is substantially reduced, total effective rate 100%；Dose
It is few, it is convenient to take, mild in medicine property and, significantly reduce the pain of patient；Quick, short treating period has no toxic side effect, treating both manifestation and root cause of disease.
Model case
Case 1：Mr. Bai, man, 39 years old, foreign enterprise's white collar was in the past 10 years, apathetic, and place to the right is lasting under upper abdomen xiphoid-process
Property secret anguish, like cut sample when aggravation, and infrascapular area is radiated to the right, and chance, which drinks, eats greasy food to aggravate, nausea and vomiting,
Sometimes yellow low water, belch acid regurgitation are vomitted, constipation is difficult to resolve, bitter taste in the mouth and dry throat, red tongue body yellow and greasy fur, wiry and frequent pulse；Through hospital diagnosis
For chronic cholecystitis.Once plurality of Chinese and Western medicine was used to be treated, the state of an illness is improved；But the Chinese medicine course for the treatment of is long, takes effect
Slowly；Western medicine easily recurs, and side effect is big；Lead to the state of an illness again and again, fails to remove root.The Chinese medicine composition of the present invention is taken, sooner or later
It is each primary；After taking a course for the treatment of, above-mentioned symptom slightly improves, and bitter taste in the mouth and dry throat gradually mitigates；After taking two courses for the treatment of, above-mentioned disease
Shape disappears, and ultrasound diagnosis gall-bladder is normal；Continuation follow-up 1 year, no relapse, the state of mind are good.
Case 2：It is single certain, man, 23 years old, student often drank and eats greasy food, started right upper quadrant of the abdomen occur before 1 year
Secret anguish, paroxysmal aggravation, nausea, sour regurgitation, symptom is aggravated after eating greasy food, ultrasound diagnosis thickening of capsule wall of gallbladder, more than 3mm, wall
Crude, interior entrant sound is poor.It was once treated using Western medicine, the state of an illness is improved, and still, is easily recurred, adverse reaction is more.Take this
The Chinese medicine composition of invention, once in the morning and once at night；After taking a course for the treatment of, above-mentioned symptom slightly improves, and nausea, sour regurgitation are subtracted
Gently；After taking two courses for the treatment of, clinical symptoms and sign disappear, and ultrasound diagnosis gall-bladder is normal；Continuation follow-up 1 year, no relapse,
The state of mind is good.
Case 3：Fang, female, 60 years old, retired professor over more than 20 years, often felt secret anguish under right rib, turgor, nausea and vomiting,
Loss of appetite, anger is got angry or feed greasy food aggravates, and like cut sample when aggravation, vomits yellow low water, yellowish fur, arteries and veins sometimes
String is slided, and ultrasound diagnosis thickening of capsule wall of gallbladder, more than 4mm, wall is crude, and interior entrant sound is poor；It is chronic cholecystitis through hospital diagnosis.Once adopted
It is treated with a variety of Chinese herbal medicines, the state of an illness is improved, and still, the course for the treatment of is long, slowly effect, is easily recurred, flavour of a drug are strong, drug administration
Digestive discomfort afterwards.The Chinese medicine composition of the present invention is taken, once in the morning and once at night；After taking a course for the treatment of, above-mentioned symptom slightly improves,
Nausea and vomiting are mitigated；After taking two courses for the treatment of, clinical symptoms and sign are substantially reduced；After taking three courses for the treatment of, above-mentioned disease
Shape disappears, and ultrasound diagnosis gall-bladder is normal；Continuation follow-up 1 year, no relapse, the state of mind are good.
Therefore, the advantageous effect of Chinese medicine composition of the invention is：It is former that the Chinese medicine composition of the present invention is selected from natural traditional Chinese medicine
Material, each taste Chinese herbal medicine compatibility is scientific and reasonable, and drug effect complements each other, and brings out the best in each other, and there is warm stomach invigorating the spleen, the inverse heat-clearing of drop, QI invigorating to live
The effect of blood, disperse accumulation resolving sputum and blood-activating analgetic, lesion depths of going directly, pair simultaneously chronic cholecystitis progress essence treatment；Meanwhile also
The microcirculation of human body can be improved, immunity of organisms is improved, to achieve the purpose that treating both manifestation and root cause of disease.Simplicity is prepared, medicine source is wide,
At low cost, dosage is few；Meanwhile mild in medicine property and taste it is moderate, without bitter taste, mild easily clothes, it is substantially non-stimulated to stomach,
It has no toxic and side effect to human body, no drug dependence, greatly reduces economy and the psychological burden of patient.Theory of traditional Chinese medical science is followed, is debated
Card treats, and symptom eliminates are fast, does not find adverse reaction after medication, and good effect, cure rate is high, for chronic cholecystitis and its concurrently
The treatment of disease has notable curative effect.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all essences in the present invention
With within principle, any modification, equivalent replacement, improvement and so on should all be included in the protection scope of the present invention god.
Claims (2)
1. a kind of Chinese medicine composition for treating chronic cholecystitis, which is characterized in that the Chinese medicine composition is by following parts by weight
Raw material is made：
15 parts of rhizoma zingiberis, 12 parts of radix scutellariae, 12 parts of radix bupleuri, 9 parts of the tuber of pinellia, 15 parts of Radix Codonopsis, 12 parts of Cortex Magnoliae Officinalis, 12 parts of turmeric, 12 parts of Radix Curcumae,
12 parts of the dried immature fruit of citron orange, 12 parts of Radix Paeoniae Alba, 10 parts of jujube, 9 parts of Radix Glycyrrhizae, 12 parts of green peel, 12 parts of root of Aucklandia lappa Decne, 12 parts of radix paeoniae rubra, giant knotweed or felwort 9
Part, 15 parts of profound Hu, 10 parts of Fructus meliae toosendan, 15 parts of malt, 9 parts of rheum officinale, 9 parts of hare's-lettuce.
2. the Chinese medicine composition for the treatment of chronic cholecystitis according to claim 1, which is characterized in that the Chinese medicine composition
Dosage form be granule, pill, oral solution, capsule or tablet.
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| CN101961481A (en) * | 2010-09-25 | 2011-02-02 | 安徽省药物研究所 | Traditional Chinese medicine for treating liver-gallbladder qi stagnation type cholecystitis and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101961481A (en) * | 2010-09-25 | 2011-02-02 | 安徽省药物研究所 | Traditional Chinese medicine for treating liver-gallbladder qi stagnation type cholecystitis and preparation method thereof |
Non-Patent Citations (1)
| Title |
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| 柴胡五金汤治疗慢性胆囊炎60例;张玉润等;《陕西中医》;20081231;第29卷(第9期);第1184页左栏第3段，右栏第2段 * |
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