CN103623291B - Chinese medicine composition of a kind of Therapeutic cancer and preparation method thereof - Google Patents

Abstract

The invention discloses Chinese medicine composition of a kind of Therapeutic cancer and preparation method thereof, it is made up of according to certain weight proportion Herba Hedyotidis Diffusae, Herba Scutellariae Barbatae, Herba Taraxaci, Herba Violae, Radix Sophorae Tonkinensis, Herba Andrographis, Folium Mori, SEMEN COICIS, Semen Maydis, Mizhi, Mel, there is the cancer that disappears, heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation, blood-activating analgetic, strengthening vital QI to eliminate pathogenic factors, medicine food, can effective Therapeutic cancer with the effect treated.

Description

Chinese medicine composition of a kind of Therapeutic cancer and preparation method thereof

Technical field

The present invention relates to a kind of Chinese medicine composition, be specifically related to Chinese medicine composition of a kind of Therapeutic cancer and preparation method thereof.

Background technology

Cancer is commonly encountered diseases and the frequently-occurring disease of a kind of serious threat human health and life, and the dead shelter that the mankind cause because of cancer has the second of mortality, is only second to cardiovascular and cerebrovascular disease, leaps to the first at the mortality rate of China's cancer.The method of western medical treatment cancer is generally now: surgical operation, X-ray therapy and chemotherapy.All there is corresponding drawback in western medicine therapy, operative treatment can only excise the tumor generated, and can not solve a difficult problem for the postoperative recurrence of cancer, diffusion and transfer; The side effect that X-ray therapy produces is very large, as common fatigue, decortication or pigment change, loss of appetite, Nausea and vomiting, alopecia etc.; Chemotherapy is tumor therapeuticing method with fastest developing speed, it is one of important means of current clinical treatment, it is the Systemic treatments of tumor, but because medicine used is all harmful, or even band toxicity, while killing cancerous cell, also can kill the normal cell in human body, produce very large toxic and side effects.Western medicine therapy causes very big damage to cancer patient's health, brings immense pressure mentally.Traditional Chinese medical herbal treatment cancer, can take stopgap measures and effect a permanent cure, and side effect is little, easy for patients to accept, and find that there is the Chinese medicine of a variety for the treatment of, prophylaxis of cancer through retrieval Patent Office of the People's Republic of China patent database, composition is different, and effect is different, and situation is different.There is in many Chinese medicine formulas the medicine also selected and can cause leukopenia or liver and cardiac muscle be had to certain infringement, think that " cancer " is " poison ", add some and be with virose Chinese medicine, treating the poisonous disease with poisonous drugs, exacerbate that sb.'s illness took a turn for the worse, also have some in the Chinese medicine of Therapeutic cancer, add some prices Chinese medicine costly, long-term taking also causes great financial burden to patient home.

Summary of the invention

For overcoming above-mentioned defect, the object of this invention is to provide Chinese medicine composition of a kind of Therapeutic cancer and preparation method thereof, this Chinese medicine composition solves the problem of above-mentioned defect, for Therapeutic cancer, there is the cancer that disappears, heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation, blood-activating analgetic, strengthening vital QI to eliminate pathogenic factors, medicine food is with the effect treated, and evident in efficacy, instant effect, cure rate is high, medication is few, have no side effect, taking convenience, cheap.Reduce relapse rate, reduce the advantage in cancerous cell diffusion and transfer etc. with uniqueness.

Inventor is in clinical treatment practice for many years, observe cancer patient's clinical symptoms in the treatment with painful, through lot of experiments, repeatedly explore the compatibility of crude drug, and the amount ranges of medicine, sum up a kind of new formula of Chinese medicine preparation of Therapeutic cancer, the problem existing for existing method can be overcome preferably, for patient removes misery.

The present invention selects Herba Hedyotidis Diffusae, Herba Scutellariae Barbatae, Herba Taraxaci, Herba Violae, Radix Sophorae Tonkinensis, Herba Andrographis, Folium Mori, SEMEN COICIS, Semen Maydis, Mizhi, Mel combines, with Herba Hedyotidis Diffusae, Herba Scutellariae Barbatae, Herba Taraxaci, Herba Violae is monarch drug, with Radix Sophorae Tonkinensis, Herba Andrographis, Folium Mori are ministerial drug, all the other various medicines are that adjuvant is formulated, all medicine compatibilities in side, the monarch and his subjects pull together, assistant makes auxiliary altogether, medicine can be disappeared cancer, heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation, blood-activating analgetic, strengthening vital QI to eliminate pathogenic factors, medicine food is with treating, each efficacy of drugs is made to produce synergism by drug regimen, in reduction relapse rate, reduce the aspects such as cancerous cell diffusion and transfer and there is unique advantage, thus can effective Therapeutic cancer.

The effect of Chinese medicine of the present invention:

Wherein:

Herba Hedyotidis Diffusae: be the whole herb with root of Radix Rubiae kind of plant Herba Hedyotidis Diffusae.Nature and flavor: bitter, sweet, cold.Nontoxic.Enter heart channel, Liver Channel, spleen channel.Effect: heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation, inducing diuresis to remove edema.There is stronger antitumor action." Guangxi Chinese medicinal herbal " controls infantile malnutrition, venom, cancerous protuberance.

Herba Scutellariae Barbatae: be the herb of labiate Herba Scutellariae Barbatae.Nature and flavor: pungent; Bitter; Cold.Return lung meridian; Liver Channel; Kidney channel.Function: heat clearing away, removing toxic substances, dissipating blood stasis, hemostasis, inducing diuresis to remove edema, analgesic therapy.There is antitumaous effect, to the late tumor of the weary art for the treatment of, be also improved symptom, Tumor suppression propagation and extend the effect of patient vitals.The composition such as Herba Hedyotidis Diffusae, Herba Lobeliae Chinensis compound compatibility is used for the treatment of kinds of tumors.

Herba Taraxaci: be feverfew Herba Taraxaci Toraxacum mongolicumHand. Mazz., alkali ground Herba Taraxaci Toraxacum borealisinenseKitam. or the dry herb belonging to several plants together.Nature and flavor: sweet, micro-hardship, cold.Enter spleen, stomach, kidney three warp.Effect: heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation." Amplification on Materia Medica addendum ": heat-transformation poison, disappears and dislikes swollen tuberculosis, Detoxicating food-poisoning, loose in vain stagnant." book on Chinese herbal medicine is newly organized ": Herba Taraxaci, bitter in the mouth, gas is put down.Enter sun bright, lunar.Burst hard swollen, disappear tuberculosis, Detoxicating food-poisoning, loose stagnant gas.

Herba Violae: be the herb of bloodroot corydalis bungeana.Nature and flavor: cold are bitter.Enter the heart, Liver Channel.Effect: heat-clearing and toxic substances removing; Subduing inflammation.

Radix Sophorae Tonkinensis: be the dry root and rhizome of dicotyledon medicine leguminous plant Sophora tonkinensis Gagnep..Nature and flavor: bitter, cold.Attach to the lung and stomach meridians.Effect: Qinghuo Jiedu, reducing swelling and alleviating pain.Radix Sophorae Tonkinensis has remarkable result to malignant tumor, and side effect is little, safety, and does not make leukopenia, and experimental animal general state is good.

Herba Andrographis: be acanthaceous plant Herba Andrographis (Andrographis paniculata(Burm.f.) Nees) herb or leaf.Nature and flavor: bitter, cold.GUIXIN, lung, large intestine, urinary bladder channel.Effect: heat-clearing and toxic substances removing, removing heat from blood, detumescence, dampness.Dehydroandrograpolide succinate has certain inhibitory action to W256 transplanted tumor.The Arginine Salts (OASKARG) that dehydroandrographolide succinate hydrogen potassium is made may have inhibitory action to the Breast cancer cellular synthesis of cultivating.

Folium Mori: be the leaf of moraceae plants Mulberry.Nature and flavor: bitter, sweet, cold.Return lung, Liver Channel.Effect: dispelling wind and heat pathogens, clearing away lung-heat and moistening for dryness, suppressing the hyperactive liver improving eyesight, cooling blood for hemostasis.Extraordinary assosting effect is had to the rehabilitation of cancer postoperative chemicotherapy patient.Folium Mori can prevent cancerous cell to generate, and improve body immunity, weaken the transfer ability of tumor.Sang Su in Folium Mori has active anticancer, and the vitamin in Folium Mori has suppression mutagen effect.

SEMEN COICIS: be grass Semen Coicis Coix lacryma-jobi L.) dry mature kernal of Stapf.Nature and flavor: sweet, be slightly cold are nontoxic.Return spleen, stomach, lung meridian.Effect: main arthralgia chiefly caused by damp pathogen, sharp the intestines and stomach, consumer edema.The effect of the polysaccharide body in Semen Coicis and Semen Coicis fat energy enhancing human body immunity function and inhibition tumor cell.

Semen Maydis: be the zeistic seed of gramineous herbaceous plant.Nature and flavor: flat, sweet.Return stomach, urinary bladder channel.Effect: whet the appetite in tune, lung benefiting mind calming, clearing away damp-heat, sharp liver and gall, slow down aging.Semen Maydis contains carbohydrate, protein, fat, carotene.Also containing the nutrient substance such as riboflavin, vitamin in Semen Maydis.Semen Maydis powder energy Tumor suppression grows, and alleviates the side effect of cancer therapy drug.

Mizhi: during for boiling congee, floats on for dense fluids on pot face.Nature and flavor: sweet are flat.Enter kidney channel.Effect: the long power of YIN nourishing, fertile the five internal organs hundred key, diuresis is treating stranguria, fluid infusion replenishing essence, has benefit always thin.There is very strong tonic effect, can match in excellence or beauty with ginseng soup.Mizhi is the elite of rice water, and nourishing power is strong, at all famous and precious not second to Radix Ginseng, Radix Rehmanniae Preparata etc. medical material.Energy tonification vigour, growth muscle power, promote health early recovery.

Mel: the Mel made for the Apidae animal close honeybee of China or apis mellifera.Nature and flavor: sweet; Flat.Return spleen; Stomach; Lung; Large intestine channel.Effect: harmonizing the spleen and stomach; Relieving spasm to stop pain; Nourishing the lung to arrest cough; Loosening bowel to relieve constipation; Skin moistening granulation promoting; Removing toxic substances.Mel can enhance metabolism, enhancing body resistance, improves hemopoietic function and tissue repair effect.

Medicine material consumption of the present invention is groped to sum up to draw through inventor in a large number, and each raw material dosage is for all to have good curative effect in following weight parts scope: Herba Hedyotidis Diffusae 100-150 part, Herba Scutellariae Barbatae 100-150 part, Herba Taraxaci 100-150 part, Herba Violae 100-150 part, Radix Sophorae Tonkinensis 100-150 part, Herba Andrographis 100-150 part, Folium Mori 100-150 part, SEMEN COICIS 100-150 part, Semen Maydis 300-600 part, Mizhi 100-150 part, Mel 100-150 part.

Wherein be preferably: Herba Hedyotidis Diffusae 125 parts, Herba Scutellariae Barbatae 125 parts, Herba Taraxaci 125 parts, Herba Violae 125 parts, Radix Sophorae Tonkinensis 125 parts, Herba Andrographis 125 parts, 125 parts, Folium Mori, SEMEN COICIS 125 parts, Semen Maydis 450 parts, 125 parts, Mizhi, Mel 125 parts.

The preparation method of Chinese medicine composition of the present invention:

Step one, first weigh Herba Hedyotidis Diffusae, Herba Scutellariae Barbatae, Herba Taraxaci, Herba Violae, Radix Sophorae Tonkinensis, Herba Andrographis, Folium Mori according to weight proportion, to break into thin medicated powder after SEMEN COICIS mix homogeneously for subsequent use;

Step 2, preparation two marmites, clean with clear water, for subsequent use;

Step 3, according to weight proportion weigh Semen Maydis break into fine powder, put into one of them clean marmite add water in right amount, be cooked into thickness sample, the maize gruel in marmite is for subsequent use;

Step 4, to weigh according to weight proportion rice wash in a pan clean after, put into the marmite that another is cleaned, add water appropriate, big fire is boiled and is changed little fiery mulling, and stewing limit, limit is stirred to thick, ceases fire, and slightly after cooling, upper strata is dense rice water, and dense rice water is Mizhi, for subsequent use;

50% of step 5, the thin medicated powder weight taken in above-mentioned steps one, puts into the marmite that step 3 holds maize gruel, stirs clockwise after mixing;

Step 6, all contained in the marmite of step 5 in the Mizhi in step 4, rapid stirring is even in the direction of the clock;

Step 7, taking Mel according to weight proportion and add in the marmite of step 6, continuing by stirring until mix completely clockwise;

Step 8, the mixture of step 7 is put into watered pill maker make water-honeyed pill, every 10 weight are one gram;

Step 9, medicated powder remaining 50% thin in step one is made powder, according to 15 grams every part packagings.

Mizhi in medicine of the present invention is the dense rice water in upper strata after being brewed into by the mixture of rice, Semen setariae or rice and Semen setariae.

Beneficial effect of the present invention:

1, the Herba Hedyotidis Diffusae in medicine of the present invention, Herba Scutellariae Barbatae, Herba Taraxaci, Herba Violae have the cancer that disappears, heat-clearing and toxic substances removing, effect of eliminating carbuncle eliminating stagnation, have antitumor, anticancer and obviously reduce the effect of tumor.

2, Radix Sophorae Tonkinensis has remarkable result to malignant tumor, and side effect is little, safety, and does not make leukopenia; Herba Andrographis heat-clearing and toxic substances removing, removing heat from blood, detumescence, has certain inhibitory action to tumor; The rehabilitation of Folium Mori to cancer postoperative chemicotherapy patient has extraordinary assosting effect, and cancerous cell can be prevented to generate, and improves body immunity, weakens the transfer ability of tumor; The effect of the polysaccharide body in Semen Coicis and Semen Coicis fat energy enhancing human body immunity function and inhibition tumor cell.

3, contain carbohydrate, protein, fat, carotene in Semen Maydis, also containing the nutrient substance such as riboflavin, vitamin, and can grow by Tumor suppression, alleviate the side effect of cancer therapy drug.Mizhi has the long power of YIN nourishing, fertile the five internal organs hundred key, and diuresis is treating stranguria, fluid infusion replenishing essence, has the thin old effect of benefit, has very strong tonic effect, can match in excellence or beauty with ginseng soup.Mizhi is the elite of rice water, and energy tonification vigour, growth muscle power, promote health early recovery.Mel can enhance metabolism, enhancing body resistance, improves hemopoietic function and tissue repair effect.

Effect that SEMEN COICIS in medicine of the present invention, Semen Maydis, Mizhi, Mel had both had a medicine also has the effect of dietetic therapy concurrently, can grow by Tumor suppression, reduce side effect, tonification vigour, there is provided body desired nutritional material: vitamin, saccharide, fat and essential amino acids etc., and be easy to chew, swallow, digest and assimilate, the nutrition problem of patient can be improved, muscle power can be increased, enhancing body resistance, reducing relapse rate, reducing the advantage in cancerous cell diffusion and transfer etc. with uniqueness, promote cancer patient's health early recovery.

Therapeutic Method of the present invention:

According to drug weight proportioning of the present invention, weighting raw materials (daily dose), each bag powder boiled water is taken after mixing it with water, simultaneously oral medicine pill 30-60 grain, every day 3-5 time.A course for the treatment of is 30 days.

According to clinical 258 routine patient view statistics, use medicine of the present invention the total effective rate course for the treatment of 90%, two the total effective rate course for the treatment of 98%.

Detailed description of the invention

Embodiment one, take Herba Hedyotidis Diffusae 100 parts, Herba Scutellariae Barbatae 100 parts, Herba Taraxaci 100 parts, Herba Violae 100 parts, Radix Sophorae Tonkinensis 100 parts, Herba Andrographis 100 parts, 100 parts, Folium Mori, SEMEN COICIS 100 parts, Semen Maydis 300 parts, 100 parts, Mizhi, Mel 100 parts, 50% of medicated powder weight portion makes powder, residue 50% makes water-honeyed pill, each bag powder boiled water is taken after mixing it with water, oral medicine pill 30 simultaneously, every day 3 times.

Following table 1 patient is the early stage patient of cancer, the clinical pharrnacokinetics report of present embodiment treatment breast carcinoma, rectal cancer, the esophageal carcinoma, laryngeal carcinoma, lymphatic cancer, nasopharyngeal carcinoma, skin carcinoma, carcinoma of prostate, bladder cancer.

Embodiment two, take Herba Hedyotidis Diffusae 100 parts, Herba Scutellariae Barbatae 100 parts, Herba Taraxaci 100 parts, Herba Violae 100 parts, Radix Sophorae Tonkinensis 100 parts, Herba Andrographis 100 parts, 100 parts, Folium Mori, SEMEN COICIS 100 parts, Semen Maydis 300 parts, 100 parts, Mizhi, Mel 100 parts, 50% of medicated powder weight portion makes powder, residue 50% makes water-honeyed pill, each bag powder boiled water is taken after mixing it with water, oral medicine pill 30 simultaneously, every day 4 times.

Following table 2 patient is the early stage patient of cancer, the clinical pharrnacokinetics report of present embodiment Hepatoma therapy.

Embodiment three, take Herba Hedyotidis Diffusae 125 parts, Herba Scutellariae Barbatae 125 parts, Herba Taraxaci 125 parts, Herba Violae 125 parts, Radix Sophorae Tonkinensis 125 parts, Herba Andrographis 125 parts, 125 parts, Folium Mori, SEMEN COICIS 125 parts, Semen Maydis 450 parts, 125 parts, Mizhi, Mel 125 parts, 50% of medicated powder weight portion makes powder, residue 50% makes water-honeyed pill, each bag powder boiled water is taken after mixing it with water, oral medicine pill 45 simultaneously, every day 4 times.

Following table 3 patient is cancer patient in mid-term, the clinical pharrnacokinetics report of present embodiment treatment gastric cancer.

Embodiment four, take Herba Hedyotidis Diffusae 150 parts, Herba Scutellariae Barbatae 150 parts, Herba Taraxaci 150 parts, Herba Violae 150 parts, Radix Sophorae Tonkinensis 150 parts, Herba Andrographis 150 parts, 150 parts, Folium Mori, SEMEN COICIS 150 parts, Semen Maydis 600 parts, 150 parts, Mizhi, Mel 150 parts, 50% of medicated powder weight portion makes powder, residue 50% makes water-honeyed pill, each bag powder boiled water is taken after mixing it with water, oral medicine pill 60 simultaneously, every day 5 times.

Following table 4 patient is cancer patient in mid-term, the clinical pharrnacokinetics report of present embodiment treatment bladder cancer.

Here is the clinical statistics data that patient uses medicine of the present invention:

One, physical data

This group statistics is the out-patient that accepts for medical treatment for 2011 to 2013 totally 258 examples, wherein man 138 example, and female 120, the age be 25-74 year mostly be person in middle and old age.

Two, criterion of therapeutical effect:

1, cure: clinical symptom disappearance or clinical symptom relief, tumor body disappears.

2, effective: tumor body reduces, do not disappear, band tumor is survived more than 2 years and is considered as effective.

3, effective: clinical symptom disappearance, tumor body has no and reduces, and life span extension is considered as effectively.

4, invalid: clinical symptoms and tumor body do not change.

Three, therapeutic outcome statistics

Wherein: total effective rate=cure rate+obvious effective rate+effective percentage

Model case and curative effect:

Case one, the summer village, Juxian County, Rizhao City XX Wei, female, 37 years old age, peasant, in May, 2011 examines, and check mammary gland Silent Neuritis lump, matter is hard, and edge is irregular, lump diameter is about 1.8cm, and with twinge in various degree, nipple has pus to flow out, and checks as breast carcinoma of early stage.After patient adopts a course for the treatment of of embodiment one treatment by Chinese herbs, mammary gland tumor disappears, and cures.

Case two, stone mortar seven village, Donggang District, Rizhao City turn round and look at XX, female, 41 years old age, company middle-ranking officials, after examining readme menstrual phase on April 15th, 2013, time also, there is unregular vaginal bleeding, gynecologial examination biopsy of drawing materials in cervix uteri, result on the 21st is that human nipple virus HPV16 type infects, and is diagnosed as cervical cancer.After patient adopts two courses for the treatment of of embodiment three treatment by Chinese herbs, transference cure, cures.

Case three, An Dongwei street, Lanshan District, Rizhao City Wu XX, man, at 45 years old age, fisherman, addicted to drinking, once suffered from fatty liver, sensation appetite obviously goes down recently, and abdominal part is vexed swollen, dyspepsia, sometimes there is Nausea and vomiting, upper right abdomen dull pain, weak, become thin, the heating of unknown cause.In January, 2013 examines rear inspection and is diagnosed as hepatocarcinoma in mid-term.After patient adopts two courses for the treatment of of embodiment four treatment by Chinese herbs, symptom obviously alleviates, effective.

Claims (4)

1. the Chinese medicine composition of a Therapeutic cancer, it is characterized in that, this Chinese medicine composition is made up of the medicine of following weight portion: Herba Hedyotidis Diffusae 100-150 part, Herba Scutellariae Barbatae 100-150 part, Herba Taraxaci 100-150 part, Herba Violae 100-150 part, Radix Sophorae Tonkinensis 100-150 part, Herba Andrographis 100-150 part, Folium Mori 100-150 part, SEMEN COICIS 100-150 part, Semen Maydis 300-600 part, Mizhi 100-150 part, Mel 100-150 part.

2. the Chinese medicine composition of Therapeutic cancer according to claim 1, it is characterized in that, be made up of the medicine of following weight portion: Herba Hedyotidis Diffusae 125 parts, Herba Scutellariae Barbatae 125 parts, Herba Taraxaci 125 parts, Herba Violae 125 parts, Radix Sophorae Tonkinensis 125 parts, Herba Andrographis 125 parts, 125 parts, Folium Mori, SEMEN COICIS 125 parts, Semen Maydis 450 parts, 125 parts, Mizhi, Mel 125 parts.

3. the preparation method of the Chinese medicine composition of the Therapeutic cancer according to claims 1 or 2, is characterized in that:

Step one, first weigh Herba Hedyotidis Diffusae, Herba Scutellariae Barbatae, Herba Taraxaci, Herba Violae, Radix Sophorae Tonkinensis, Herba Andrographis, Folium Mori according to weight proportion, to break into thin medicated powder after SEMEN COICIS mix homogeneously for subsequent use;

Step 2, preparation two marmites, clean with clear water, for subsequent use; Step 3, according to weight proportion weigh Semen Maydis break into fine powder, put into one of them marmite and add water in right amount, be cooked into thickness sample medicated porridge, maize gruel is for subsequent use; Step 4, to weigh according to weight proportion rice wash in a pan clean after, put into another marmite, add water appropriate, big fire is boiled and is changed little fiery mulling, and stewing limit, limit is stirred to thick, ceases fire, and slightly after cooling, upper strata is dense rice water, and dense rice water is Mizhi, for subsequent use; 50% of step 5, the thin medicated powder weight taken in step one puts into the maize gruel of step 3, stirs clockwise after mixing;

Step 6, all contained in the marmite of step 5 in the Mizhi in step 4, rapid stirring is even in the direction of the clock; Step 7, to take Mel according to weight proportion and add in step 6 and continue by stirring until mix completely clockwise; Step 8, the mixture of step 7 is put into watered pill maker make water-honeyed pill, every 10 weight are one gram; Step 9, by step one remain 50% thin medicated powder make powder, according to 15 grams every part packagings.

4. the preparation method of the Chinese medicine composition of Therapeutic cancer according to claim 3, is characterized in that: described rice is the mixture of rice, Semen setariae or rice and Semen setariae arbitrary proportion.