CN110393769A - A kind of anticancer Chinese medicine composition and preparation method thereof - Google Patents

A kind of anticancer Chinese medicine composition and preparation method thereof Download PDF

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CN110393769A
CN110393769A CN201910686071.4A CN201910686071A CN110393769A CN 110393769 A CN110393769 A CN 110393769A CN 201910686071 A CN201910686071 A CN 201910686071A CN 110393769 A CN110393769 A CN 110393769A
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chinese medicine
medicine composition
cancer
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翁玉金
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/36Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/58Reptiles
    • A61K35/583Snakes; Lizards, e.g. chameleons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/63Arthropods
    • A61K35/646Arachnids, e.g. spiders, scorpions, ticks or mites
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/63Arthropods
    • A61K35/648Myriapods, e.g. centipedes or millipedes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06Fungi, e.g. yeasts
    • A61K36/062Ascomycota
    • A61K36/066Clavicipitaceae
    • A61K36/068Cordyceps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/37Celastraceae (Staff-tree or Bittersweet family), e.g. tripterygium or spindletree
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/75Rutaceae (Rue family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/896Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/896Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8966Fritillaria, e.g. checker lily or mission bells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH

Abstract

The present invention relates to a kind of anticancer Chinese medicine composition, the raw material including following parts by weight: 20~40 parts of great Bei, 20~40 parts of cortex dictamni, 20~40 parts of old Cowhells, 20~40 parts of pangolin, 10~30 parts of scorpion, 5~25 parts of centipede, 5~15 parts of snake, 5~15 parts of Cordceps militaris.Compared with prior art, the beneficial effects of the present invention are: the present invention has effects that stronger low in cost, anticancer, builds up health, toxin expelling, when actual therapeutic, according to the difference of patient's actual conditions, under the premise of without departing from the composition principle of the Chinese medicine composition, the dosage of ingredients is adjusted in the range in the present invention, achieves very significant therapeutic effect.Clinical application confirms, the no matter traditional decocting decoction of the present invention or through preferred method extract preparation Chinese patent drug, no matter be used alone, or with Western medicine drug combination, the present invention achieves unexpected good result in the treatment of cancer field, and has no any toxic side effect.

Description

A kind of anticancer Chinese medicine composition and preparation method thereof
Technical field
The present invention relates to technical field of traditional Chinese medicines, in particular to a kind of anticancer Chinese medicine composition and preparation method thereof.
Background technique
Cancer is the general designation of a major class malignant tumour.The characteristics of cancer cell is to make patient's body without limitation, without end hyperplasia Interior nutriment is largely consumed;Cancer cell releases a variety of toxin, and human body is made to generate a series of symptoms;Cancer cell can also turn Move on to whole body growth and breeding everywhere, cause human body syntexis, inability, anaemia, loss of appetite, fever and serious organ function by Damage etc..On the other side have a benign tumour, and benign tumour is then easy to remove clean, does not shift generally, does not recur, to organ, Tissue only squeezes and blocking action, but cancer (malignant tumour) can also destroy the structure and function of tissue, organ, cause necrosis Bleeding concurrent infection, patient are dead finally due to organ failure.
Why can the mankind suffer from cancer the veil of the serious illness: human body cell has been opened in numerous medical researches and clinical test It is source of ten thousand diseases that electronics, which is grabbed, and active oxygen (free radical ROS) is a kind of substance (unsaturated electron species) for lacking electronics, into Electronics is fought for everywhere after entering human body, if seizing the electronics of cell protein molecule, so that protein is connected branch and is alkylated, shape It is carcinogenic at the molecule of distortion.The distortion molecule removes the electronics for capturing neighboring molecule due to oneself lacking electronics again, and makes neighbour Nearly molecule is also distorted and carcinogenic.In this way, vicious circle just will form the protein molecular largely to distort, the albumen of these distortion When molecule breeding duplication, gene mutation.A large amount of cancer cells are formed, cancer finally occur.Physician points out that cancer disease due to is: body Environmental pollution, chemical contamination (chemical toxicant), ionising radiation, free radical toxin, microorganism (bacterium, fungi, virus etc.) and Under the action of the various carcinogens of its metabolic toxicities, hereditary capacity, endocrine imbalance, immunologic function disorder etc., carcinogenic factor It is leading to that canceration occurs for body normal cell as a result, the normal cell paraplasm for showing themselves in that local organization and the part that is formed is swollen Block.Cancer is organism normal cell major class disease caused by more reasons, multistage and multiple mutation.
Generally directed to the treatment means of cancer, including radical surgery, palliative operation, the operation of detecting property.Wherein: (1) Radical surgery: since malignant growth is fast, surface does not have coating, it and normal surrounding tissue do not have apparent boundary, office Portion's infiltration is severe, and can be shifted by lymphatic vessel.Therefore, operation is tumour and its a certain range of normal tissue of surrounding and can The lymph node that can be invaded thoroughly is cut off.It is this operation be suitable for range of tumor compared with limitation, without the good disease of DISTANT METASTASES IN, constitution People.(2) palliative operation;Range of tumor is wider, has the end-stage patients for shifting and cannot making radical surgery, to mitigate pain Hardship maintains nutrition and extending life, cut-out tumour or can do some the operation for mitigating symptom, such as fistulization.(3) it visits The property looked into operation: is needed out by chest, abdomen is opened or opens when not can determine that its property by various inspections sometimes for the internal organ in deep swollen object Cranium checks the form of lump, and meat is with distinguishing its property or cutting a fritter living tissue quick frozen-section inspection, after clarifying a diagnosis Determine operation and therapeutic scheme, again for the operation of detecting property.
And treatment and health care are carried out by Chinese medicine, widely approved by domestic and international Medical Technologist, a large amount of clinical examination It tests and scientific research has confirmed that the effect of Chinese traditional treatment cancer.In medical literature in ancient times, the early disease about cancer Cause, name of disease and treatment method, such as mammary cancer (i.e. breast cancer), kidney rock (also known as carcinoma of the penis like cauliflower, i.e. glans penis cancer), tongue rock (i.e. tongue Cancer), dysphagic (i.e. cancer of the esophagus), a lump in the abdomen causing distension and pain (various abdominal tumors or metastatic carcinoma), malignant sore (i.e. cutaneum carcinoma), goiter (i.e. lymph Cancer or metastatic carcinoma), bulging (cancer Complicated With Ascites), the retention of urine (urinary cancer) etc..There are mainly two types of methods, i.e. mouth for treatment aspect Clothes and external application Chinese medicine, acupuncture cut root therapy.(1) the common Chinese medicine for the treatment of cancer: ganoderma lucidum, Chinese yew, toad, cordyceps sinensis, west American ginseng, scorpio, Radix Astragali, Radix Angelicae Sinensis, Radix Notoginseng, gynostemma pentaphylla, oldenlandia diffusa, lobelia chinensis, edible tulip, folium cycas, semen coicis etc..(2) The prescription for the treatment of cancer: it opens diaphragm and dissipates, leads to and imprison soup, Shengmai Yin, wuwei xiaodu drink, Yinchenhao Tang, Oriental Wormwood Decoction, bupleurum powder for relieving liver-qi, yiguan decoction etc.. (3) acupuncture cuts root therapy: the reflecting point of disease is found out on the huatuo spine points of back, is pierced into acupuncture point (reflecting point) with acupuncture needle, The level using method of point different muscle and fascia shells fiber disconnected, and pulls out upper cupping jar or vacuum tank in darting station, allows extravasated blood It is flowed out from pinprick with dirty things.According to the different state of an illness, acupoint selection position and number are all not quite similar.In addition, Chinese medicine is sent out in surgery Exhibition Shi Shangyu internal medicine development advance side by side, but it is rare for the treatment surgery of cancer refer to, modern medicine study table It is bright, not only there is the factor for accelerating metastasis cancer cell growth in the primary tumor of cancer, while also having and inhibiting metastasis cancer cell growth The factor, so if cancer has transfer and there is no because in the case where the compressing threat to life of carcinoma, medical treatment is most Good selection.
Summary of the invention
The purpose of the present invention is to provide a kind of overcome the deficiencies in the prior art, can cure or alleviate stomach, intestinal cancer disease And malignant tumour, the reduction of patient state of an illness play certain health-care effect.
To achieve the above object, the present invention is implemented with the following technical solutions:
A kind of anticancer Chinese medicine composition, the raw material including following parts by weight: 20~40 parts of great Bei, cortex dictamni 20~40 Part, 20~40 parts of old Cowhells, 20~40 parts of pangolin, 10~30 parts of scorpion, 5~25 parts of centipede, 5~15 parts of snake, Cordceps militaris 5~ 15 parts.
The Chinese medicine composition further includes the raw material of following parts by weight: 15~35 parts of Ornithogalum caudatum.
The Chinese medicine composition is formed by the raw material proportioning of following parts by weight: 40 parts of great Bei, 40 parts of cortex dictamni, old ox 40 parts of muscle, 20 parts of pangolin, 10 parts of scorpion, 5 parts of centipede, 5 parts of snake, 5 parts of Cordceps militaris.
The Chinese medicine composition is formed by the raw material proportioning of following parts by weight: 40 parts of great Bei, 40 parts of cortex dictamni, old ox 40 parts of muscle, 20 parts of pangolin, 10 parts of scorpion, 5 parts of centipede, 5 parts of snake, 5 parts of Cordceps militaris, 15 parts of Ornithogalum caudatum.
Pill, tablet, pulvis, capsule, granule, liquid agent is made in the Chinese medicine composition.
Pill, tablet, pulvis, capsule, granule, liquid agent is made in the Chinese medicine composition.
A kind of preparation method of anticancer Chinese medicine composition, the preparation method include: to take the medicinal material, extracting in water 1~4 time, each amount of water is 5~10 times of amounts by weight, and each extraction time is 1~3 hour, filtering, and merging filtrate is dense Contracting, gained extract dry crush.
A kind of preparation method of anticancer Chinese medicine composition, the preparation method include: to take great Bei, cortex dictamni, old ox With vinegar heating and refluxing extraction 1~4 time, each quantity of solvent is 2~7 times of amounts, each extraction time by weight by muscle, Ornithogalum caudatum It is 1~3 hour;It filters, merging filtrate, is concentrated after filtrate recycling ethanol, obtains alcohol-extracted extract, it is spare;The dregs of a decoction and pangolin, scorpion Son, centipede, snake, Cordceps militaris mixing, extracting in water 1~4 time, each amount of water is 2~10 times of amounts by weight, when extracting every time Between be 1~3 hour;Filtering, merging filtrate, filtrate concentration is medicinal extract, mixes, dry, pulverize with the alcohol-extracted extract.
Compared with prior art, the beneficial effects of the present invention are:
The present invention has effects that stronger low in cost, anticancer, builds up health, toxin expelling, when actual therapeutic, according to disease The difference of people's actual conditions, under the premise of without departing from the composition principle of the Chinese medicine composition, ingredients in the present invention Dosage is adjusted in the range, achieves very significant therapeutic effect.Clinical application confirms no matter the present invention passes The decocting decoction of system still through preferred method extract preparation Chinese patent drug, no matter be used alone, or with Western medicine drug combination, this Invention achieves unexpected good result in the treatment of cancer field, and has no any toxic side effect.
Specific embodiment
Everyone falls ill inevitably in life, it is important to the attitude of disease.Ill morning is controlled, disease-free morning prevents, cancer is strangled In budding state and develop on the way, inventor takes up a job as a doctor more than 50 years, and clinic application " medicine propylhomoserin " has cured minor illness, prevented serious disease cancer Generation.In short, preventing the generation of cancer, it is most important to cure minor illness.Small disease minor illness is considered as cancer, initially specific occurs Performance, just because of just thering are 2.5 to die of cancer in every dead 10 people in China, accounting for the 25% of death toll.The so boundless universe, rue Whether rue all living creatures have 25% people to be eventually developed to cancer, and the morning and evening only fallen ill is different.People so around our daily lifes How many people suffers from cancer, so the specific manifestation all small disease, minor illness being all considered as before carcinogenesis is not excessive, it is The alarm signal that cancer occurs.Their certain functions, which are contrary to, normally makes one to feel the feeling far from health.Body metabolism will at this time Corresponding variation occurs, necessarily makes corresponding body reaction.It is the protection mechanism of body, starting adjusts system of defense and generates one Serial reaction.Such as loss of appetite, indigestion, body tiredness, thinking be difficult, it is some do not enter small disease minor illness scope.But It has been the initial performance that cancer occurs.
The present age, scientist found that the generation of human tumor shows the variation of cell, people first with the reach of science People has oncogene, everybody has the possibility of generation.But it is eventually developed to the extremely a small number of of cancer.Neoplastic disease is called body cell something lost Pass disease.It is caused by body cell inhereditary material changes.China's Chinese medicine recognizes " first native endowments to the generation of tumour very early Deficiency is assigned, will be lost in maintenance the day after tomorrow, then constitution is weaker, and healthy tendency wants empty, and it is human body retention without going that body imbalance, which causes " accumulation ", Lump ".Cancer is described incisively and vividly, and indicates orientation treatment.Explicitly point out tumour be it is endogenic, Body lacks material composition and occurs.Native endowment is insufficient, is exactly ectrogeny, foetal period missing, everybody lacks, everybody is necessary After mend.Illustrate, Chinese medicine just recognizes inadequate natural endowment to tumour generation very early, will lose the day after tomorrow and mends in tune.It has been determined that pathogenic factors is conciliate Certainly method.Regrettably any substance has not been lacked certainly, causes very large disaster to the mankind.Even to this day side is cracked, and lacks " medicine propylhomoserin " has been lost, " the medicine propylhomoserin " of missing has been supplemented, has rooted out morbidity root, taken leave of cancer.
The expert of the world-renowned scientist composition of world's cancer foundation and Cancer in China foundation 21 different subjects Group quinquenniad summarizes the influence to cancer occurrence and development such as various kinds of foods, movement, proposes " pre- anti-cancer 10 It is big to suggest having functions of cancer prevention and life prolonging ".Wherein nine with eat it is related, only one movement.Recognize that anti-cancer is not detached to eat, only there is no card According to not yet which food can really prevent carcinogenesis certainly.To obtain correct option, goes to experience in daily life, goes to send out It is existing.The generation of the real pre- anti-cancer of energy of those foods is affirmed, cancer fundamentally just solves.Science is not mysterious, and one Words, eat health, eat up cancer.
The 4th phase oncogene of " Popular Medicine " nineteen ninety --- the latent seed of trouble in the cell.Yan Hui points out that " oncogene is ground Study carefully conclusion, originally virus, later external infections or other so-called " carcinogens " are not the most direct root that cancer occurs, And root is in cell therein ".Body cell inhereditary material has missing, and cell changes -- mutation.Mutation is once It can be transmitted by certain way to offspring after having occurred.Native endowment deficiency is fully confirmed, will be lost the day after tomorrow in this of maintenance It says.Inadequate natural endowment, everybody is insufficient, everybody has the possibility of generation, but occurs still a small number of.So our daily lifes are all The people enclosed, perhaps have occurred that in the crowd of small disease minor illness should how many people suffered from cancer, sufferers themselves do not know yet Road.It is mostly to go to a doctor nearby to the medical institutions of base, always as one can imagine facing so huge " stealth " tumor patient It does not go to step on " refined taste ".Thus the great responsibility of general practitioner is assigned.
General practitioner is also specialist, because he has oneself unique service object and service range, use unique Medical concept and methodology.With unique theoretical and principle, provide with the visibly different service of other specialists, especially curing It treats in health care system, produces the effect that other any specialists can not replace.It is to solve community's Common Health Problems, is related to The problem of a variety of trainings, global question.It is the expert of a variety of trainings.
General practitioner is responsible for the detection to neoplastic disease, including morbidity, the investigation of dead and Prevalence rate and follow-up to neoplastic disease Work, generation, discovery, tissue, management, monitoring, the follow-up work of neoplastic disease.The occurrence and development of neoplastic disease are a lengthy procedures. It awards general practitioner and observes and prevent to provide time enough section.Reinforce prevention and health care, prevent trouble before it happens, is prevented in early stage, held Carry on a shoulder pole the great responsibility for reducing cancer generation.The generation for controlling cancer prevents predictable unexpected generation, improves the process of cancer And prognosis, improve therapeutic effect.It is final to save resource, it improves benefit.Exempt and checks, treats etc. various expenses.It greatly prolongs The life expectancy value of people.
General practitioner can not replace medical and health work, other any specialists.Especially cancer, the first granulocyte become It is different to develop to clinical findings cancer, need 6-10 even 30-40.Oncologist is to patient, it is of interest that discovery cancer cell How to treat afterwards, palliates the agonizing sufferings and extend life cycle.From prevention angle analysis, discovery cancer cell has been advanced stage, is lost already pre- Anti- meaning.General practitioner is concerned with the weather and health status for not finding the former several years many decades of cancer cell.It controls More minor illness prevents the generation of serious disease cancer.
The new knowledge rule of development
Cancer can never calmness develop.It is the incremental regularity for gradually developing, own being truly had to develop.It is sending out Exhibition can be divided into three periods on the way.It is treated for the morbidity root of cancer, is exactly searched for the primary cause of disease in treatment.Cancer is born lacks Weary, everybody lacks " medicine propylhomoserin ", everybody has oncogene, everybody has the possibility of generation, still, morbidity or a small number of.Such as What can early find that the clinic of inventor's many years is realized.Early most basic one of discovery is exactly to observe.Never ignore those when observation Seem usual subtle phenomenon.Examine the details of those less noticeable mistakes.By pondering deeply, grasp is more known Know, relevant facts and disease are connected with knowledge, it is definite to diagnose, is especially wanted to cancer follow-up observation decades after medication, And it has to accomplish, obtains final sumbission.This is only result of really tracing to its source.
The variation of matter has occurred in cellular genetic material itself, and biological character is caused to change, and is referred to as mutated.Mutation can occur In body cell, i.e., cell mutation, this mutation can cause the form of contemporary biology or the hair of the certain cancers of variation physiologically It is raw.Cancer cell is that cell spontaneous mutation generates, and has a very long development of evil in febrile disease process, is not to complete quickly in this generation cell, But pass through tens of secondary propagate up to a hundred and connect generation, it is a genetic process.This conversion needs one and fits easy condition and a phase When the long time.It generally, is the form and function of cell to be gradually changed, by quantitative change to matter on the basis of hereditary variation Become, by being gradient to mutation, mutation is exactly canceration.Occur to development need for quite a long time, several years many decades, tumour gives us It prevents and treats it and leaves enough time section.China only has 20% carninomatosis people to be diagnosed, undiscovered there are also 80%, in person also not Know that oneself has been fallen ill.So huge ' stealth ' tumor patient is faced, we must sharpen understanding its rule of development.It gives Prevention provides more reliable foundation.We will see cancer to various performances caused by body damage, and corresponding tissue occurs as soon as Pathological reaction.The pervious morbid state of cancer cell has not yet been formed, claim ' precancerous lesion ' in this very long years, it is incremental Gradually develop, it is divided into three periods;Probationary period;Incubation period;The precancerous lesion phase claims ' first three phase of cancer '.
The first phase, probationary period: since body lacks substance, there is allergy in corresponding tissue, and human body is in healthy Asia State between health.And certain functions are contrary to the feeling for normally making one to feel separate health, that is, body metabolism will occur Corresponding variation.Corresponding body reaction is necessarily made, starting adjusts system of defense, generates series reaction.Such as: skin sticks Film, capillary are shunk, and cause endocrine disorder, dysfunction, not normal generation retardance of blood flow etc., to generate some symptoms Such as: fever, it is tired out, have a pain in the back, poor sleep, psychology it is fidgety, arrhythmia cordis, be short of breath, sweat gland secretion increases or reduce, Night sweat, gastric secretion imbalance, loss of appetite, indigestion, the general body of body be tired, burns in low fever, spirit wither door leaf, DOMS without Power, lassitude, thinking difficulty, depression, shortness of breath and fatigue, dizziness, dizziness etc. it is some do not enter small disease minor illness scope, also not It was found that organic disease.It can be repaired by the regulating system of itself, if exceeding itself adjustable range, it will be into The development of one step.
The second phase, incubation period: the form of cell gradually changes, and has increasing for significant amounts, and form not yet changes, disease This variation of neo-confucian is referred to as Simple hyperplasia, and the lesion of local cells not only indicates localized variation, also necessarily reflects The functional state of entire body is not yet found and the essential difference on normal cell metabolism, it is difficult to recognize the true and false herein.There is disease Shape is similar like benign disease and common disease.Such as, chronic gastrointestinal diseases, cat fever, swelling and aching of gum, unknown lump etc. cause carefully The quantitative change of born of the same parents.Inflammation is seemed there are also some, as pelvic inflammatory disease, tonsillitis, thyroiditis, rhinitis, mazoitis, allergic dermatitis, The diseases such as erysipelas, erythema nodosum, chorionitis, cell have occurred and that hyperplasia, without characteristic symptom, to body without too big damage Evil, it, which is not increased to, should height, be not present to the mind, do not go to step on ' refined taste ', be hospital's whole body physical examination.Doctor It can only be handled by general diseases.Hardly realize and further develops.
The third phase, the precancerous lesion phase: cell gradually changes the form and function of cell on the basis of hereditary variation.It does not send out Essential difference on existing normal cell and cancer cell metabolism, but the form of cell and quantity have significant change.It is generally acknowledged that Before cancer cell formation, it will pass through this stage.This is the last leg developed to cancer cell, without precancerous lesion, Just there is no cancer.There is benign tumour or disease in body.Such as, the lump not disappeared is touched, significant change occurs for mole, the proliferation of mammary gland, gulps down Swallow unfavorable, pipe intestinal polyp sample adenoma, atrophic gastritis, mucous epithelium severe atypical hyperplasia, bloody sputum dry cough, stool band Blood or mucus, nasopharyngeal secretions with blood, diplopia headache, Keratoderma, leukoplakia, the ulcer not recovered for a long time, fistula, reason not Bright weight loss, menstrual period are outer or post menopausal is irregularly bled, the cirrhosis phase, senile skin angling, continue celostomia, enjoy it is poor Blood, diarrhea constipation alternating person, neck region lump, painless hematuria, cervix erosion, etc. lesion, these disease canceration rates are higher, It is more dangerous.These are to gather song before cancer cell differentiation, oneself has been developed a long period, existing medical technology and are set Standby, can not find out cancer cell and cannot make a definite diagnosis is cancer.When doctor can not be changed into cancer cell certainly, when diffusion transfer, only It watches waiting quietly, maintains vigilance, the consulting further consultation of doctor there is gone every the several months, although doctor can be according to blood test and pathology point The progress to predict cell is analysed, but these means cannot always provide satisfactory perspective report.Cancer cell is found in waiting It has been advanced stage, prevention angle analysis loses prevention meaning already.
The development of first three phase disease of cancer has had longer time, and several years many decades, this just gives, and we provide preventions Period correctly recognizes that various performances listed by three phase diseases have to be vigilant, because they are cancer early stage exposures Clues and traces are intercepted so carrying out prophylactic treatment immediately, are prevented and treated and are developed to cancer cell.In any one of ' three phases ' ring It is intercepted on section, reverses abnormal cell to normal, reverse transfer condition is exactly treatment means.One has been kept away to open for treatment tumour New way.Many diseases reach an advanced stage all more refractory.Cancer is even more so, because not only local lesion's destruction is huge for cancer of late stage Greatly, and distant place transfer occurs.Early stage local failure is small, and does not shift, and is relatively easy in treatment, intercepts in first three phase of cancer, no The single control development of disease, it is often more important that prevent the generation of cancer.Missing substance is supplemented in any stage, is exempted from by itself The coordination of epidemic disease power can then control cancer in ' stationary state ' or before people is dead also have not enough time to cause to endanger to human body Evil.To disease before cancer must control it is early control it is small be sure not to delay, cured the generation that minor illness prevents serious disease cancer.Three phase symptoms are not bright Aobvious boundary line separates, and each tissue inside and outside body occurs, position different symptoms are different, but have to be vigilant, they are cancers The alarm signal of disease.
Three phase diseases, for the general practitioner of base's outpatient service, it is quotidian that is seen and treated patients daily, which is not minority, Thing.The clinic records of many decades record true Couple herbs, and the allotment of drug is finally drafted out in clinical application many times One Chinese medicinal formulae, modern medicine study include a variety of amino acid, temporarily claim " medicine propylhomoserin " sharp to human body hundred and none evil.Treatment Three phase diseases, " medicine propylhomoserin " are preferred.
The drug of three phase lesions can be controlled, the substance lacked when must occur containing cancer.This be only cured it is small Disease prevents the real factor of serious disease.
The early detection of tumour at present, entirely lean on patient oneself, discovery can hip actively see a doctor, give a clue, There are two types of people to prevent the infantile tumour patient of tumor development one is seeking medical advice with the doubtful point of oneself;One is tumours to have arrived evening The patient that phase oneself is not recognized also., consciously to cancer attack, the latter unconsciously appoints cancer to endanger for the former.Cause this difference Reason is the height of the presence or absence of tumor knowledge and anti-cancer vigilance.The great disparity of consequence is self-evident.
Why cancer is occurred
Proto-oncogene: former from word meaning: to refer to originally, originally.Original is the hyle of life, i.e. human life sheet It is former.Also refer to it is congenital, it is congenital i.e. existing from birth, refer to that people looks like in embryonic stage.Congenital constitution is insufficient, for morbidity it is inherent because Element.Congenital is natural endowment in parent, and inherent, it is the day after tomorrow that the thing for the intake that paddles one's own canoe after leaving parent, which is formed by,.
Former base: i.e. in body early embryo, certain tissue (or region) of the following adult is formed.In more some books and data Further modification and affirmative.Such as the presence of 1, " life evolution " oneself primary oncogene of discovery of page 147, a variety of cancers can be caused Generation.2, " gene therapy is shallow for " Popular Medicine " o. 11th Wu Min Tumour Inst., Chinese Medical Academy page 8 in 1989 Release " the intrinsic proto-oncogene of human body.
Described above, the presence of oneself the primary oncogene of discovery of human body and the intrinsic proto-oncogene of human body refer to together congenital, normal , there is oncogene in foetal period, everybody has oncogene.Sufficiently prove, ectrogeny, everybody lack, foetal period defective gene It is exactly oncogene.What can normal fetus lack everybody has oncogene, everybody has a possibility of generation, but actual life Middle morbidity or a small number of, the clinical observation of many years is careful the study found that in the pink of condition before some morbidities, without and Doctor beat dealings, catches a cold and did not also occur, seldom medication, or even unused medicine at all times, can not have to before the onset Does not small disease minor illness occur really for medicine people falls ill inevitably in life.Entered on this question patient the single world and they Carry out communication exchange.In the patient of all talks, nearly all there are common similar experiment and feeling.Several years is very before the onset of some To many decades, firepower decline is accepted as unavoidable, summer, To Be Protected from Heat, and in autumn, two legs are cold and cool, and night is more very;Some two legs of night feel bad, Nowhere place;The more slept the more cold before some dawn;Some cough night-time attacks or exacerbation.I takes exception to this for these performances, Not think to influence to eat, drink, work, disease cannot be calculated, do not need the doctor that seeks help, oneself total energy solves, and symptom totally disappeared after getting up, than eating Medicine is also efficacious.Some trials drug, it is ineffective, abandon treating.It is therefore seen that it is very, not that they do not have medication before the onset It is not fall ill, what they obtained is all night-time attack, the diseases such as night aggravates and lower limb are cold and cool.These inappreciable diseases are long And the long body that causes has no parry sb.'s blows, can't bear the heavy load, falling ill is exactly cancer.As the distinctive typical identification of cancer.
Why not cancer is occurred
The majority that occupies of cancer does not occur for the people around daily life, especially those people that small disease minor illness often occurs, and some is aobvious Must be fragile, it seeks medical advice and medicine everywhere, but they are not easy to obtain cancer.They take good care of body very much, somewhat uncomfortable just to look for Doctor, therapeutic effect is not just in accordance with the wish, just finds someone better qualified and the doctor of surrounding is very familiar with, take drugs many kinds of, person " sickly person " oneself also recognizes whirlpool misery.Many years concentrate on studies, and it must be everywhere that small disease minor illness, which will not shy, which walks cancer, Ask that medicine, some drugs control minor illness, it is therefore prevented that the generation of serious disease cancer.Why say the people often to catch a cold, cancer does not occur, by This confirmation is that drug controls carcinogenesis.Namely during treatment flu, carcinogenesis can control.Therefore it is understood that be assorted Common medicine can prevent carcinogenesis.
New method chemoprophylaxis
Just us is taken to go ahead the understanding of Chinese herbal treatment tumour, to know which Chinese herbal medicine has anti-curing oncoma It imitates it is necessary to carry out the screening of thousands of kinds of drugs.It was found that some drugs are effective, then use with clinical patient.Especially For prevention, follow-up several years many decades must be tracked.
The Chinese Academy of Sciences institute of oncology Liu Yunyuan professor said in " large area reduces tumour " article: " we During tumor development, some drugs intervening measure is taken, also has not enough time to show before ' normal ' death of someone Harm of the tumour to him.This is a kind of effective approach.This analytic approach is exactly a part of biological statistical method.
Illustrate that the traditional chinese medicine composition of the invention makees the treatment of cancer to below the present invention below with clinical test results With, but do not limit the present invention in any way:
Embodiment one
A kind of anticancer Chinese medicine composition, the raw material including following parts by weight: 20 parts of great Bei, 20 parts of cortex dictamni, old ox Muscle 20, part, 20 parts of pangolin, 30 parts of scorpion, 15 parts of centipede, 15 parts of snake, 15 parts of Cordceps militaris.
Pill, tablet, pulvis, capsule, granule, liquid agent is made in the Chinese medicine composition.
A kind of preparation method of anticancer Chinese medicine composition, the preparation method include: to take the medicinal material, extracting in water 1~4 time, each amount of water is 5~10 times of amounts by weight, and each extraction time is 1~3 hour, filtering, and merging filtrate is dense Contracting, gained extract dry crush.
Embodiment two
A kind of anticancer Chinese medicine composition, the raw material including following parts by weight: 30 parts of great Bei, 30 parts of cortex dictamni, old ox 30 parts of muscle, 30 parts of pangolin, 20 parts of scorpion, 15 parts of centipede, 10 parts of snake, 10 parts of Cordceps militaris.
Pill, tablet, pulvis, capsule, granule, liquid agent is made in the Chinese medicine composition.
A kind of preparation method of anticancer Chinese medicine composition, the preparation method include: to take the medicinal material, extracting in water 1~4 time, each amount of water is 5~10 times of amounts by weight, and each extraction time is 1~3 hour, filtering, and merging filtrate is dense Contracting, gained extract dry crush.
Embodiment three
A kind of anticancer Chinese medicine composition, the raw material including following parts by weight: 40 parts of great Bei, 40 parts of cortex dictamni, old ox 40 parts of muscle, 20 parts of pangolin, 10 parts of scorpion, 5 parts of centipede, 5 parts of snake, 5 parts of Cordceps militaris.
Pill, tablet, pulvis, capsule, granule, liquid agent is made in the Chinese medicine composition.
A kind of preparation method of anticancer Chinese medicine composition, the preparation method include: to take the medicinal material, extracting in water 1~4 time, each amount of water is 5~10 times of amounts by weight, and each extraction time is 1~3 hour, filtering, and merging filtrate is dense Contracting, gained extract dry crush.
Example IV
A kind of anticancer Chinese medicine composition, the raw material including following parts by weight: 20 parts of great Bei, 20 parts of cortex dictamni, old ox 20 parts of muscle, 20 parts of pangolin, 30 parts of scorpion, 15 parts of centipede, 15 parts of snake, 15 parts of Cordceps militaris, 35 parts of Ornithogalum caudatum.
Pill, tablet, pulvis, capsule, granule, liquid agent is made in the Chinese medicine composition.
A kind of preparation method of anticancer Chinese medicine composition, the preparation method include: to take great Bei, cortex dictamni, old ox With vinegar heating and refluxing extraction 1~4 time, each quantity of solvent is 2~7 times of amounts, each extraction time by weight by muscle, Ornithogalum caudatum It is 1~3 hour;It filters, merging filtrate, is concentrated after filtrate recycling ethanol, obtains alcohol-extracted extract, it is spare;The dregs of a decoction and pangolin, scorpion Son, centipede, snake, Cordceps militaris mixing, extracting in water 1~4 time, each amount of water is 2~10 times of amounts by weight, when extracting every time Between be 1~3 hour;Filtering, merging filtrate, filtrate concentration is medicinal extract, mixes, dry, pulverize with the alcohol-extracted extract.
Embodiment five
A kind of anticancer Chinese medicine composition, the raw material including following parts by weight: 30 parts of great Bei, 30 parts of cortex dictamni, old ox 30 parts of muscle, 30 parts of pangolin, 20 parts of scorpion, 15 parts of centipede, 10 parts of snake, 10 parts of Cordceps militaris, 25 parts of Ornithogalum caudatum.
Pill, tablet, pulvis, capsule, granule, liquid agent is made in the Chinese medicine composition.
A kind of preparation method of anticancer Chinese medicine composition, the preparation method include: to take great Bei, cortex dictamni, old ox With vinegar heating and refluxing extraction 1~4 time, each quantity of solvent is 2~7 times of amounts, each extraction time by weight by muscle, Ornithogalum caudatum It is 1~3 hour;It filters, merging filtrate, is concentrated after filtrate recycling ethanol, obtains alcohol-extracted extract, it is spare;The dregs of a decoction and pangolin, scorpion Son, centipede, snake, Cordceps militaris mixing, extracting in water 1~4 time, each amount of water is 2~10 times of amounts by weight, when extracting every time Between be 1~3 hour;Filtering, merging filtrate, filtrate concentration is medicinal extract, mixes, dry, pulverize with the alcohol-extracted extract.
Embodiment six
A kind of anticancer Chinese medicine composition, the raw material including following parts by weight: 40 parts of great Bei, 40 parts of cortex dictamni, old ox 40 parts of muscle, 20 parts of pangolin, 10 parts of scorpion, 5 parts of centipede, 5 parts of snake, 5 parts of Cordceps militaris, 15 parts of Ornithogalum caudatum.
Pill, tablet, pulvis, capsule, granule, liquid agent is made in the Chinese medicine composition.
A kind of preparation method of anticancer Chinese medicine composition, the preparation method include: to take great Bei, cortex dictamni, old ox With vinegar heating and refluxing extraction 1~4 time, each quantity of solvent is 2~7 times of amounts, each extraction time by weight by muscle, Ornithogalum caudatum It is 1~3 hour;It filters, merging filtrate, is concentrated after filtrate recycling ethanol, obtains alcohol-extracted extract, it is spare;The dregs of a decoction and pangolin, scorpion Son, centipede, snake, Cordceps militaris mixing, extracting in water 1~4 time, each amount of water is 2~10 times of amounts by weight, when extracting every time Between be 1~3 hour;Filtering, merging filtrate, filtrate concentration is medicinal extract, mixes, dry, pulverize with the alcohol-extracted extract.
Said medicine pharmacology explanation:
(1) great Bei: clearing heat and eliminating phlegm opens strongly fragrant dissipating bind.For wind-heat, scorching, phlegm-fire cough, pulmonary abscess, acute mastitis, scrofula, sore, Ambition is gloomy.
(2) cortex dictamni: heat-clearing and damp-drying drug, wind-dispelling removing toxic substances is bitter, cold, enters lung channel, can be clearly in the heat evil of lung, and golden gas is respectful clearly, cough From disappearing, for damp and hot sore, yellow water is dripping, eczema, scabies sore leprosy, beriberoid pyretic arthralgia, jaundice and reddish urine, the mattress taro contained in cortex dictamni The alkaloids such as alkali, dictamine, trigonelline have inhibiting effect to various bacteria and fungi, and cortex dictamni can help anticancer, from white Isolated Cen skin ketone in fresh hide ether extract, dictamine and a kind of colourless transparent liquid derived from volatile oil are that it is external anti- The effective component of cancer, 45% concentration can kill ehrlich ascites cancer, S180 and U14 cell.
(3) old Cowhells: clearing heat and detoxicating, dissipating stasis and stanching bleeding and other effects, for preventing encephalitis, epidemic meningitis etc., moreover it is possible to treat rheumatism pass Pain, jaundice, hepatopathy are saved, heat fever, child convulsion, stranguria, difficult urination, dysentery, hematochezia, sore swell and ache curative, traumatic injury, dog are hurt It bites.
(4) pangolin: taste is salty;Cold nature, channel tropism: Liver Channel;Stomach meridian, pangolin have blood circulation promoting and dispersing pathogen accumulation, the carbuncle that disappears of invigorating blood circulation, detumescence row Purulence;It is newborn under promoting menstruation;The effect of anti-stain in solid, pangolin cure mainly blood stasis;Disorder lump in the abdomen;Rheumatic arthralgia;Agalactia;Carbuncle swells;Scrofula Scrofula.
(5) scorpion: treatment frightened epilepsy, rheumatism, hemiplegia, facial paralysis, deaf puckery, spasm of hands and feet etc..Scorpion venom has The effect of wind-dispelling, removing toxic substances, analgesic, dredging collateral, the water of scorpio, alcohol extracting thing respectively have significantly human hepatocellular and colon cancer cell Inhibiting effect.Scorpio crude extract can direct cancer inhibitting and killing cell, still have higher inhibiting rate to tumour growth after drug withdrawal, to esophagus Cancer, liver cancer, colon cancer etc. have certain curative effect, and scorpion nutritive value is abundant, are important nutrient health.
(6) centipede: poison, dissipating bind are attacked in wind-dispelling, arresting convulsion.Control apoplexy, frightened epilepsy, tetanus, pertussis, scrofula, tuberculosis, disease product Tumor mass, sore swollen toxin, wind tinea is white bald, anal fistula, scald, centipede leech injection can make the spermatogonium of small white mouse necrose, It disappears, illustrates there is inhibiting effect to tumour cell.
(7) snake: warm lung, beneficial cardiovascular, beneficial liver, stomach function regulating, kidney tonifying, strengthening tendons, bone strengthening, beauty care lead to blood, and anti-inflammatory stops Bitterly, yin-nourishing qi-restoratives.
(8) Cordceps militaris: Cordyceps militaris is sweet in flavor, warm-natured, enters lung, kidney two warp, has the effect of tonifying lung is relievingd asthma, it is big that Cordyceps militaris has four Cordyceps sinensis ingredient: cordycepin, cordycepic acid, Cordyceps sinensis polysaccharide and cordyceps sinensis SOD.Cordyceps sinensis polysaccharide is that a kind of highly branched galactomannan is poly- Sugar, it can promote lymphocyte transformation, improve the antibody content of serum IgG and the immune function of body, and enhancing body itself is anti- The ability of cancer suppression cancer.And SOD (superoxide dismutase) can eliminate superoxide radical in body, and there is anti-aging, anticancer to press down The effect of cancer.So Cordyceps militaris possesses unique anticancer function.Cordyceps militaris selenium (Se) also rich in, this microelement By it is acknowledged be the essential trace elements of the human body, the normal permeability of the stability of cell membrane can be protected, and stimulate and exempt from The generation of epidemic disease globulin and antibody enhances immunity of organism and oxidation resistance.
(9) Ornithogalum caudatum: have it is clearing heat and detoxicating disappear hard dissipating bind the effect of, have superstrong anticancer activity, superpower blocking cancer Cell growth, enhances chemicotherapy effect, releases chemicotherapy toxicity, and immunocyte living is hit in potent analgesic, enhances immune function, mentions The ability of high antiviral, pure Chinese medicine plant is without any side effects, and system germ is killed in effectively suppression, virus.
Experimenter
The village A, Jilin Province, father Liu Xianfeng, cholangiocarcinoma are taken medicine 8 months, extend the service life 7 years.
The village A, Jilin Province, mother Liu Xianfeng, the carcinoma of the rectum are taken medicine 4 months, extend the service life 6 years.
The village A, Jilin Province, Han Liyou, bladder cancer are taken medicine 3 months, recovery from illness, are not recurred within more than 10 years.
The village A, Jilin Province, Weng Yuwu, bladder cancer are taken medicine 6 months, and recovery from illness, cerebral hemorrhage is dead after 5 years.
The village A, Liaoning Province, Wang Jinrong, breast cancer, hand postoperative metastasis thoracic cavity are taken medicine 6 months, recovery from illness.
The village A, Liaoning Province, Wang Pinjun, gastric cancer are taken medicine 4 months, recovery from illness.
The village A, Liaoning Province, Cheng Yujiang, gastric cancer are taken medicine 4 months, recovery from illness.

Claims (8)

1. a kind of anticancer Chinese medicine composition, which is characterized in that the raw material including following parts by weight: 20~40 parts of great Bei, white 20~40 parts of fresh hide, 20~40 parts of old Cowhells, 20~40 parts of pangolin, 10~30 parts of scorpion, 5~25 parts of centipede, snake 5~15 Part, 5~15 parts of Cordceps militaris.
2. a kind of anticancer Chinese medicine composition according to claim 1, which is characterized in that the Chinese medicine composition also wraps Include the raw material of following parts by weight: 15~35 parts of Ornithogalum caudatum.
3. a kind of anticancer Chinese medicine composition according to claim 1, which is characterized in that the Chinese medicine composition by with The raw material proportioning of lower parts by weight forms: 40 parts of great Bei, 40 parts of cortex dictamni, 40 parts of old Cowhells, 20 parts of pangolin, 10 parts of scorpion, 5 parts of centipede, 5 parts of snake, 5 parts of Cordceps militaris.
4. a kind of anticancer Chinese medicine composition according to claim 1 or 2, which is characterized in that the Chinese medicine composition It is formed by the raw material proportioning of following parts by weight: 40 parts of great Bei, 40 parts of cortex dictamni, 40 parts of old Cowhells, 20 parts of pangolin, scorpion 10 Part, 5 parts of centipede, 5 parts of snake, 5 parts of Cordceps militaris, 15 parts of Ornithogalum caudatum.
5. a kind of anticancer Chinese medicine composition according to claims 1 to 3, which is characterized in that the Chinese medicine composition system At pill, tablet, pulvis, capsule, granule, liquid agent.
6. a kind of anticancer Chinese medicine composition according to claim 4, which is characterized in that ball is made in the Chinese medicine composition Agent, tablet, pulvis, capsule, granule, liquid agent.
7. a kind of preparation method of anticancer Chinese medicine composition according to claim 1 or 3, which is characterized in that described Preparation method includes: to take the medicinal material, and extracting in water 1~4 time, each amount of water is 5~10 times of amounts by weight, is extracted every time Time is 1~3 hour, filtering, merging filtrate, concentration, and gained extract dry crushes.
8. a kind of preparation method of anticancer Chinese medicine composition according to claim 4, which is characterized in that the preparation Method includes: to take great Bei, cortex dictamni, old Cowhells, Ornithogalum caudatum with vinegar heating and refluxing extraction 1~4 time, and each quantity of solvent is with weight Amount is calculated as 2~7 times of amounts, and each extraction time is 1~3 hour;It filters, merging filtrate, is concentrated after filtrate recycling ethanol, obtains alcohol extracting Medicinal extract, it is spare;The dregs of a decoction are mixed with pangolin, scorpion, centipede, snake, Cordceps militaris, and extracting in water 1~4 time, each amount of water is with weight Amount is calculated as 2~10 times of amounts, and each extraction time is 1~3 hour;Filtering, merging filtrate, filtrate concentration is medicinal extract, with the alcohol Extracted extract mixing, dry, pulverize.
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CN109908250A (en) * 2019-03-15 2019-06-21 李德金 A kind of Traditional Chinese medicine liniment and preparation method thereof for treating laryngocarcinoma

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Application publication date: 20191101