CN105456565A - Traditional Chinese medicine preparation for treating hepatitis A and preparation method thereof - Google Patents
Traditional Chinese medicine preparation for treating hepatitis A and preparation method thereof Download PDFInfo
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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Abstract
The invention provides a traditional Chinese medicine preparation for treating hepatitis A and a preparation method thereof. The traditional Chinese medicine preparation is prepared from Lepisorus pseudonudus, Pteris multifda poir, Adina pilulifera(Lam.)Franch et Drake, roots of Riparian Homonoia, Iris dichotoma Pall., Sageretia thea (Osbeck) Johnst., S.uncinata, Glechoma hederacea L., Camellia sinensis(L.)O.KuntzeThea sinensis L., Lysimachia hemsleyana, Cirsium bracteiferum, rhizomes of Largeleaf Curculigo, Lysimachia candida Lindl., full grass of Rungia pectinata (L.) Nees, Chinese Milkwort herb, Cotinus coggygria Scop, Lepisorus contortus and rhizoma Belamcandae. The traditional Chinese medicine preparation has the advantages that the traditional Chinese medicine preparation has an definite treatment effect on treating hepatitis A when used in cooperation with a western medicine traditional method, and is free of toxic and side effects.
Description
Technical field
The present invention relates to the medicinal preparation containing deriving from plant, animal or mineral component, particularly relating to a kind of Chinese medicine preparation for the treatment of hepatitis A and preparation method thereof.
Background technology
Hepatitis A, be called for short hepatitis A, hepatitis A, caused, based on the infectious disease of inflammation pathological changes by hepatitis A virus (HAV), propagate mainly through fecal oral route, clinically with tired, loss of appetite, hepatomegaly, abnormal liver function is main manifestations, there is jaundice in some cases, main manifestations is acute hepatitis, and symptomless infection person is common.Any age all can suffer from primary disease, but is mainly Children and teenager.The general comparatively child of clinical symptoms of adult's hepatitis A attaches most importance to.Winter-spring season is often the peak period of hepatitis A morbidity.The primary disease course of disease is self limiting, and without chronicity, person is extremely rare to cause acute severe hepatitis, and along with inactivated vaccine is in global use, the popular of hepatitis A is controlled effectively.
Summary of the invention
Technical problem to be solved by this invention is, provides a kind of Chinese medicine preparation for the treatment of hepatitis A and preparation method thereof, Chinese medicine preparation of the present invention, coordinates doctor trained in Western medicine traditional method to use, and have definite curative effect to treatment hepatitis A, toxic and side effects is little.
In order to solve the problems of the technologies described above, the invention provides a kind of Chinese medicine preparation for the treatment of hepatitis A, its raw medicinal material comprises: Lepisorus pseudonudus Ching, Herba Cheilanthes chusane, Ramulus et Folium Adinae Piluliferae, Radix Homonoiae Ripariae, flat cattail leaf fan, Cacumen et folium sageretiae, Herba Asplenii Incisi, Europe HUOXUEDAN, Radix Camelliae sinensis, Lysimachia hemsleyana, Radix Cirsii Belingshanici, Rhizoma Curculiginis Capitulatae, Herba Lysimachiae Candidae, Herba rungiae pectinatae, Herba Polygalae Chinensis, Ramulus et folium cotini coggygriae, Herba Lepisori Contorti and Iris dichotoma Pall．.
In described Chinese medicine preparation, the ratio of weight and number of each raw medicinal material is as follows: Lepisorus pseudonudus Ching 5 ~ 20 parts, Herba Cheilanthes chusane 35 ~ 45 parts, Ramulus et Folium Adinae Piluliferae 5 ~ 15 parts, Radix Homonoiae Ripariae 10 ~ 20 parts, flat cattail leaf fan 10 ~ 25 parts, Cacumen et folium sageretiae 15 ~ 25 parts, Herba Asplenii Incisi 10 ~ 25 parts, Europe HUOXUEDAN 10 ~ 20 parts, Radix Camelliae sinensis 5 ~ 15 parts, Lysimachia hemsleyana 44 ~ 45 parts, Radix Cirsii Belingshanici 10 ~ 20 parts, Rhizoma Curculiginis Capitulatae 15 ~ 25 parts, Herba Lysimachiae Candidae 10 ~ 20 parts, Herba rungiae pectinatae 15 ~ 25 parts, Herba Polygalae Chinensis 10 ~ 25 parts, Ramulus et folium cotini coggygriae 10 ~ 20 parts, Herba Lepisori Contorti 5 ~ 20 parts and Iris dichotoma Pall． 5 ~ 15 parts.
In described Chinese medicine preparation, the ratio of weight and number of each raw medicinal material is as follows: Lepisorus pseudonudus Ching 10 ~ 20 parts, Herba Cheilanthes chusane 38 ~ 45 parts, Ramulus et Folium Adinae Piluliferae 10 ~ 15 parts, Radix Homonoiae Ripariae 15 ~ 20 parts, flat cattail leaf fan 10 ~ 20 parts, Cacumen et folium sageretiae 15 ~ 20 parts, Herba Asplenii Incisi 18 ~ 25 parts, Europe HUOXUEDAN 15 ~ 20 parts, Radix Camelliae sinensis 10 ~ 15 parts, Lysimachia hemsleyana 38 ~ 45 parts, Radix Cirsii Belingshanici 15 ~ 20 parts, Rhizoma Curculiginis Capitulatae 20 ~ 25 parts, Herba Lysimachiae Candidae 10 ~ 18 parts, Herba rungiae pectinatae 15 ~ 20 parts, Herba Polygalae Chinensis 10 ~ 22 parts, Ramulus et folium cotini coggygriae 10 ~ 15 parts, Herba Lepisori Contorti 10 ~ 20 parts and Iris dichotoma Pall． 10 ~ 15 parts.
In described Chinese medicine preparation, the ratio of weight and number of each raw medicinal material also can be preferably: Lepisorus pseudonudus Ching 18 parts, Herba Cheilanthes chusane 43 parts, Ramulus et Folium Adinae Piluliferae 12 parts, Radix Homonoiae Ripariae 18 parts, flat cattail leaf fan 13 parts, Cacumen et folium sageretiae 18 parts, Herba Asplenii Incisi 20 parts, Europe HUOXUEDAN 20 parts, Radix Camelliae sinensis 13 parts, Lysimachia hemsleyana 39 parts, Radix Cirsii Belingshanici 18 parts, Rhizoma Curculiginis Capitulatae 23 parts, Herba Lysimachiae Candidae 17 parts, Herba rungiae pectinatae 15 parts, Herba Polygalae Chinensis 20 parts, Ramulus et folium cotini coggygriae 12 parts, Herba Lepisori Contorti 18 parts and Iris dichotoma Pall． 12 parts.
In described Chinese medicine preparation, the ratio of weight and number of each raw medicinal material also can be preferably: Lepisorus pseudonudus Ching 14 parts, Herba Cheilanthes chusane 38 parts, Ramulus et Folium Adinae Piluliferae 14 parts, Radix Homonoiae Ripariae 16 parts, flat cattail leaf fan 19 parts, Cacumen et folium sageretiae 17 parts, Herba Asplenii Incisi 23 parts, Europe HUOXUEDAN 17 parts, Radix Camelliae sinensis 11 parts, Lysimachia hemsleyana 44 parts, Radix Cirsii Belingshanici 16 parts, Rhizoma Curculiginis Capitulatae 22 parts, Herba Lysimachiae Candidae 14 parts, Herba rungiae pectinatae 18 parts, Herba Polygalae Chinensis 15 parts, Ramulus et folium cotini coggygriae 15 parts, Herba Lepisori Contorti 12 parts and Iris dichotoma Pall． 15 parts.
Present invention also offers the preparation method of above-mentioned Chinese medicine preparation, when the dosage form of described Chinese medicine is decoction, its preparation method comprises the following steps:
Step one: purple casserole is put in described raw medicinal material mixing, adds clear water, to clear water dipped medical material upper surface 2-5cm, soak 3-10 hour;
Step 2: purple casserole is placed on fire, after intense fire boils, using slow fire instead, to decoct the 30-50 minute dosage to medicinal liquid be slowly 100-300ml, filters, obtain filtrate a, for subsequent use;
Step 3: residue medicinal residues are added clear water again, to clear water dipped medical material upper surface 2-3cm, soaks 3-10 hour;
Step 4: be placed in by purple casserole on fire, after intense fire boils, using slow fire instead, to decoct the 25-35 minute dosage to medicinal liquid be slowly 100-300ml, filters, obtain filtrate b, mixed by filtrate a and filtrate b.
Present invention also offers the preparation method of above-mentioned Chinese medicine preparation, when the dosage form of described Chinese medicine is capsule, its preparation method comprises the following steps:
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;
3rd step, adds Pulvis Talci, magnesium stearate successively in the micropowders that second step obtains, and carries out mixing process, obtains capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.15 ~ 0.5:0.15 ~ 0.5, incapsulate in housing by described capsule 's content, obtain capsule finished product.
Beneficial effect of the present invention: Chinese medicine preparation of the present invention, coordinates doctor trained in Western medicine traditional method to use, and has definite curative effect, have no side effect to treatment hepatitis A.
Detailed description of the invention
The invention provides a kind of Chinese medicine preparation for the treatment of hepatitis A, its raw medicinal material comprises: Lepisorus pseudonudus Ching, Herba Cheilanthes chusane, Ramulus et Folium Adinae Piluliferae, Radix Homonoiae Ripariae, flat cattail leaf fan, Cacumen et folium sageretiae, Herba Asplenii Incisi, Europe HUOXUEDAN, Radix Camelliae sinensis, Lysimachia hemsleyana, Radix Cirsii Belingshanici, Rhizoma Curculiginis Capitulatae, Herba Lysimachiae Candidae, Herba rungiae pectinatae, Herba Polygalae Chinensis, Ramulus et folium cotini coggygriae, Herba Lepisori Contorti and Iris dichotoma Pall．.
In described Chinese medicine preparation, the pharmacology of each raw medicinal material is as follows:
Lepisorus pseudonudus Ching: [another name] Zha Bai (Tibetan name).[source] is the herb of Plants of Polypodiaceae Lepisorus pseudonudus Ching.Xia Qiu gathers, and dries.[nature and flavor] micro-sweet micro-hardship, is slightly cold.[return through] enters liver, the heart, lung meridian.[function cures mainly] clearing away heat and promoting diuresis, treatment of arthritis and promoting collateral and channels, detumescence hemostasis, separates sulfur poison.Control gonorrhea, hematuria, dysentery, consumptive disease heat cough, hematmesis due to visceral injury, incised wound.[extracts] " Chinese medicine voluminous dictionary "
Herba Cheilanthes chusane: [another name] offers chicken tail, Herba pteridii latiusculi is cracked rice in Zhoushan, thin Herba Pteridis Multifidae, phoenix road chicken, iron wire road chicken, kind chicken tail, Strepopelia orientalis tail, blood grass, close chi, small capital something that gives the game away Herba pteridii latiusculi, spire Rhizoma Seu Herba Pteridis Dactylinae.[source] medical material Ji Yuan: for Sinopteridaceae vegetable hair axle is cracked rice the herb of Herba pteridii latiusculi.[nature and flavor] micro-hardship; Cold; Nontoxic.[return through] kidney; Bladder; Large intestine channel.[function cures mainly] clearing away heat-damp and promoting diuresis; Removing toxic substances.Main jaundice due to damp-heat; Have loose bowels; Dysentery; Difficulty and pain in micturition; Laryngopharynx swelling and pain; Carbuncle furuncle; Venom.[extracts] " China's book on Chinese herbal medicine " " Chinese medicine voluminous dictionary "
Ramulus et Folium Adinae Piluliferae: [another name] Rheum alexandrae Batal. cutter, Green Dragon pearl, wear slice of fish, false Fructus Myricae rubrae, water to add in Dwelling, small stream cotton sliver, MANSHANXIANG, globe daisy Fructus Adinae, water tiltedly, Shui Lishu.[source] medical material Ji Yuan: be branch and leaf or the flowers and fruits of dicotyledon medicine Maguireothamnus speciosus Ramulus et Folium Adinae Piluliferae.[nature and flavor] bitter in the mouth, puckery, cool in nature.[return through] liver; Spleen; Large intestine channel.[function cures mainly] clearing heat and expelling damp; Eliminating stasis to stop pain; Arresting bleeding and healing up ulcer.Main dysentery; Intestinal is scorching; Edema; Carbuncle sore tumefacting virus; Eczema; Ulcer being unable to heal; Wound hemorrhage.[extracts] " Chinese medicine voluminous dictionary "
Radix Homonoiae Ripariae: [another name] water cone wood, thin willow.[source] medical material Ji Yuan: be the root of euphorbia plant water willow son.Gather and store: annual all right sides are excavated, and clean earth, section, dries.[nature and flavor] are bitter; Cold.[return through] liver; Gallbladder; Urinary bladder channel.[function cures mainly] heat clearing away; Function of gallbladder promoting; Diuresis; Removing toxic substances.Main acute, chronic hepatitis; Cholecystitis; Cholelithiasis; Vesical calculus; Gonorrhea; Prunus mume (sieb.) sieb.et zucc. poison; Hemorrhoid; Traumatic injury; Scald.[extracts] " national Chinese herbal medicine compilation "
Flat cattail leaf fan: [another name] discrimination flower Rhizoma Iridis Tectori, fan fan grass, white Rhizoma Belamcandae, Iris dichotoma Pall．, wild flag.The flat cattail leaf fan of [source] Iridaceae, is used as medicine with herb and root.[nature and flavor] are bitter, cold.Slightly poisonous.[function cures mainly] heat-clearing and toxic substances removing, promoting blood circulation and detumescence.Cure mainly laryngopharynx swelling and pain, tonsillitis, hepatitis, hepatomegaly, stomachache, mastitis.[extracts] " national Chinese herbal medicine compilation "
Europe HUOXUEDAN: [source] medical material Ji Yuan: be the herb of labiate Europe HUOXUEDAN.Gather and store: aerial parts of gathering May, cleaning and dry.[nature and flavor] sweet in the mouth; Pungent; Cold nature.Woods is led in [function cures mainly] heat clearing away; Cholagogic and lithagogue; Promoting blood flow to regulate menstruation.Main pyretic stranguria; Stranguria with blood; Sha Lin; Stranguria caused by urinary stone; Cholelithiasis; Hepatitis; Menoxenia.[extracts] " China's book on Chinese herbal medicine "
Radix Camelliae sinensis: [source] medical material Ji Yuan: be the root of plant of theaceae tea.[nature and flavor] are bitter; Cool.[return through] heart; Kidney channel.The diuresis of [function cures mainly] heart tonifying; Promoting blood flow to regulate menstruation; Heat-clearing and toxic substances removing.Main heart disease; Edema; Hepatitis; Dysmenorrhea; Sore swollen toxin; Aphtha; Soup fire is burnt; Herpes zoster; Psoriasis.[extracts] " China's book on Chinese herbal medicine "
Lysimachia hemsleyana: [another name] Radix Berchemiae Yunnanensis, outdoor Lysimachia christinae Hance, outdoor Herba Lysimachiae.[source] medical material Ji Yuan: be the herb of Ofthe Primulaceae Lysimachia hemsleyana.Gather and store: summer gathers, using fresh herb or dry.[nature and flavor] micro-hardship; Cool in nature.[function cures mainly] clearing away heat-damp and promoting diuresis; Stimulate the menstrual flow.Main hepatitis; Pyelonephritis; Cystitis; Amenorrhea.[extracts] " China's book on Chinese herbal medicine "
Radix Cirsii Belingshanici: [another name] stings lid greatly.[source] is the root of feverfew Luoping Ji.Autumn adopts root, dries.[nature and flavor] are bitter, flat.[function cures mainly] removing heat from blood, diuretic, dispels the wind, tonify deficiency.Control haematemesis, hematochezia, edema disease, weak, traumatic injury, carbuncle and ulcer is red and swollen, prurigo, scabies.[extracts] " Chinese medicine voluminous dictionary "
Rhizoma Curculiginis Capitulatae: [source] medical material Ji Yuan: be the rhizome of bloodwort great Ye Rhizoma Curculiginis.Gather and store: summer, autumn excavate, except defoliation, clean, section is dried.[nature and flavor] are pungent; Micro-hardship; Temperature.[return through] kidney; Lung; Liver Channel.[function cures mainly] kidney invigorating and YANG supporting; Expelling wind and removing dampness; Promoting blood flow to regulate menstruation.Main cough with asthma of suffering from a deficiency of the kidney; Impotence and seminal emission; Nebulousurine leukorrhagia; Soreness of the waist and knees; Rheumatic arthralgia; Cold womb is infertile; Menoxenia; Metrorrhagia; Uterine prolapse; Traumatic injury.[extracts] " China's book on Chinese herbal medicine "
Cacumen et folium sageretiae: [another name] thorn Fructus Myricae rubrae, to joint bar, sour prunus mume (sieb.) sieb.et zucc. le, letter prunus mume (sieb.) sieb.et zucc., thorn evening, to grafting, tumor poison rattan, pluck wood, Sageretia theezans acid, five metals is imperial, rock small stream stores, to joint sting.[source] medical material Ji Yuan: be the root of Rhamnaceae plant Cacumen et folium sageretiae.[nature and flavor] are sweet; Light; Flat.[return through] lung; Kidney channel.[function cures mainly] sending down the abnormal ascending QI; Reduce phlegm; Expelling wind and removing dampness.Main cough; Asthma; Stomachache; The arthroncus of knee; Edema.[extracts] " China's book on Chinese herbal medicine "
Herba Asplenii Incisi: [another name] Herba Selaginellae Moellendorfii, wild Cupressaceae (" conventional glossary of Herbs and Drugs among the people "), red snow phoenix tail, Herba Vernoniae Cinereae, Folium Callicarpae Formosanae, stone Scolopendra, lobule Herba Pteridis Multifidae, little pheasant tail, the prosperous youngster of wall, wall brocade, rock spring grass (" Zhejiang conventional medical herbs among the people ").[source] is the herb of Aspleniaceae plant tiger tail Asplenium trchomanes L..[nature and flavor] " Zhejiang conventional medical herbs among the people ": " light, cool ".[function cures mainly] heat clearing away, dampness removing, relieving convulsion, removing toxic substances.Control cough due to lung-heat, spit blood, acute icteric infectious hepatitis, acute infantile convulsion wind, dactylitis.[extracts] " Chinese medicine voluminous dictionary "
Herba Lysimachiae Candidae: [another name] Herba Lysimachiae Fortunei, clever disease grass, golden pheasant gallbladder, plain boiled water flower, water borax, successively Huang.[source] medical material Ji Yuan: be herb or the root of Ofthe Primulaceae pool Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis).[nature and flavor] are bitter; Cool in nature.[return through] spleen; Kidney channel.[function cures mainly] heat-clearing and toxic substances removing; Promoting blood circulation and stopping pain; Li Wen subsides a swelling.Main laryngopharynx swelling and pain; Carbuncle sore tumefacting virus; Acute mastitis; Venom; Injury and bone fracture; Rheumatic arthralgia; Beriberi.[extracts] " China's book on Chinese herbal medicine "
Herba rungiae pectinatae: [another name] blue grass (" Guangzhou flora "), bright calyx grass (" seed plant title "), by Yue grass, wasp careless (" Guangdong Chinese medicine " II), JIYAOCAO, native Spica Prunellae (Guangzhou air force " conventional Chinese herbal medicine handbook ").[source] is the herb of acanthaceous plant Herba rungiae pectinatae.By the winter in the Summer Solstice, all can gather.[nature and flavor] sweetness and bitterness, cool.[function cures mainly] liver heat removing and eyesight improving, removing food stagnancy dysentery relieving.Treating the liver is scorching, and acute binding film is scorching, food stagnation of child, dysentery, lymphoid tuberculosis.[extracts] " Chinese medicine voluminous dictionary "
Herba Polygalae Chinensis: [another name] Fei Ercao, Radix Picriae felterrae, francolin tea, Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae), Herba Polygalae Telephioidis, great Lan are blue or green, great Jin is careless, the conjunctions period of the day from 11 a.m. to 1 p.m, infantile malnutrition grass, pachydermia Citrus chachiensis Hort., greatly Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae), greatly Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae) grass, slope Pennisetum centrasiaticum Tzvel, Taurus Radix Polygalae, Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae), grass of feeling at ease, winged steed, leaf leaf YIZHIHUA, Herba Polygalae Telephioidis, Radix cycleae barbatae, greasy medicine worm.[source] medical material Ji Yuan: be the whole herb with root of milk wort south China plant Radix Polygalae.[nature and flavor] are pungent; Sweet; Flat.[return through] lung; Spleen channel.[function cures mainly] eliminates the phlegm; Removing food stagnancy; Dissipating blood stasis; Removing toxic substances.Main cough pharyngalgia; Infantile malnutrition; Traumatic injury; Scrofula; Carbuncle; Venom.[each discussion] 1. " detailed outline is picked up any lost article from the road ": control children's all expectorant disease and acute filthy diseases.2. " register planted by Guangxi medicine ": control traumatic injury, jaundice, hepatitis, red Hakuri.[extracts] " China's book on Chinese herbal medicine "
Ramulus et folium cotini coggygriae: [source] medical material Ji Yuan: be the branch and leaf of Anacardiaceae plant ash colourea smoketree and Mao Ye Ramulus et Folium Cotini Coggygiae.[nature and flavor] are bitter; Pungent; Cold.[return through] kidney; Liver Channel.[function cures mainly] heat-clearing and toxic substances removing; Promoting blood circulation and stopping pain.Main icterohepatitis; Erysipelas; Dermatitis rhus; Burn due to hot liquid or fire; Conjunctivitis; Traumatic injury stasis of blood pain.[extracts] " China's book on Chinese herbal medicine "
Herba Lepisori Contorti: [another name] little lung muscle.[source] medical material Ji Yuan: for Plants of Polypodiaceae turns round the herb of Herba Lepisori Thunbergiani.Gather and store: spring, summer gather, connecting rhizome and pull up, going silt to clean, dry.[nature and flavor] are slightly cold; Micro-hardship.[return through] heart; Liver Channel.[function cures mainly] promoting blood circulation and stopping pain; Heat-clearing and toxic substances removing.Main burn and scald; Suppurative infection; The puckery pouring pain of heat; Laryngopharynx swelling and pain; Traumatic injury; Traumatic hemorrhage.[extracts] " China's book on Chinese herbal medicine "
Iris dichotoma Pall．: [source] medical material Ji Yuan: be rhizome or the herb of irides wild flag.Gather and store: herb of gathering spring, rhizome of gathering autumn, using fresh herb or cutting are dried.[nature and flavor] are bitter; Pungent; Cold; Slightly poisonous.[return through] lung; Stomach; Liver Channel.[function cures mainly] heat-clearing and toxic substances removing; Promoting blood circulation and detumescence; Pain relieving cough-relieving.Main throat, gingival swelling and pain; Mumps; Acute mastitis; Stomachache; Hepatitis; Hepatosplenomegaly; Lung-heat cough with asthma; Traumatic injury; Paddy field property dermatitis.[extracts] " China's book on Chinese herbal medicine "
In described Chinese medicine preparation, the ratio of weight and number of each raw medicinal material is as follows: Lepisorus pseudonudus Ching 5 ~ 20 parts, Herba Cheilanthes chusane 35 ~ 45 parts, Ramulus et Folium Adinae Piluliferae 5 ~ 15 parts, Radix Homonoiae Ripariae 10 ~ 20 parts, flat cattail leaf fan 10 ~ 25 parts, Cacumen et folium sageretiae 15 ~ 25 parts, Herba Asplenii Incisi 10 ~ 25 parts, Europe HUOXUEDAN 10 ~ 20 parts, Radix Camelliae sinensis 5 ~ 15 parts, Lysimachia hemsleyana 44 ~ 45 parts, Radix Cirsii Belingshanici 10 ~ 20 parts, Rhizoma Curculiginis Capitulatae 15 ~ 25 parts, Herba Lysimachiae Candidae 10 ~ 20 parts, Herba rungiae pectinatae 15 ~ 25 parts, Herba Polygalae Chinensis 10 ~ 25 parts, Ramulus et folium cotini coggygriae 10 ~ 20 parts, Herba Lepisori Contorti 5 ~ 20 parts and Iris dichotoma Pall． 5 ~ 15 parts.
In described Chinese medicine preparation, the ratio of weight and number of each raw medicinal material can be preferably: Lepisorus pseudonudus Ching 10 ~ 20 parts, Herba Cheilanthes chusane 38 ~ 45 parts, Ramulus et Folium Adinae Piluliferae 10 ~ 15 parts, Radix Homonoiae Ripariae 15 ~ 20 parts, flat cattail leaf fan 10 ~ 20 parts, Cacumen et folium sageretiae 15 ~ 20 parts, Herba Asplenii Incisi 18 ~ 25 parts, Europe HUOXUEDAN 15 ~ 20 parts, Radix Camelliae sinensis 10 ~ 15 parts, Lysimachia hemsleyana 38 ~ 45 parts, Radix Cirsii Belingshanici 15 ~ 20 parts, Rhizoma Curculiginis Capitulatae 20 ~ 25 parts, Herba Lysimachiae Candidae 10 ~ 18 parts, Herba rungiae pectinatae 15 ~ 20 parts, Herba Polygalae Chinensis 10 ~ 22 parts, Ramulus et folium cotini coggygriae 10 ~ 15 parts, Herba Lepisori Contorti 10 ~ 20 parts and Iris dichotoma Pall． 10 ~ 15 parts.
In described Chinese medicine preparation, the ratio of weight and number of each raw medicinal material also can be preferably: Lepisorus pseudonudus Ching 18 parts, Herba Cheilanthes chusane 43 parts, Ramulus et Folium Adinae Piluliferae 12 parts, Radix Homonoiae Ripariae 18 parts, flat cattail leaf fan 13 parts, Cacumen et folium sageretiae 18 parts, Herba Asplenii Incisi 20 parts, Europe HUOXUEDAN 20 parts, Radix Camelliae sinensis 13 parts, Lysimachia hemsleyana 39 parts, Radix Cirsii Belingshanici 18 parts, Rhizoma Curculiginis Capitulatae 23 parts, Herba Lysimachiae Candidae 17 parts, Herba rungiae pectinatae 15 parts, Herba Polygalae Chinensis 20 parts, Ramulus et folium cotini coggygriae 12 parts, Herba Lepisori Contorti 18 parts and Iris dichotoma Pall． 12 parts.
In described Chinese medicine preparation, the ratio of weight and number of each raw medicinal material also can be preferably: Lepisorus pseudonudus Ching 14 parts, Herba Cheilanthes chusane 38 parts, Ramulus et Folium Adinae Piluliferae 14 parts, Radix Homonoiae Ripariae 16 parts, flat cattail leaf fan 19 parts, Cacumen et folium sageretiae 17 parts, Herba Asplenii Incisi 23 parts, Europe HUOXUEDAN 17 parts, Radix Camelliae sinensis 11 parts, Lysimachia hemsleyana 44 parts, Radix Cirsii Belingshanici 16 parts, Rhizoma Curculiginis Capitulatae 22 parts, Herba Lysimachiae Candidae 14 parts, Herba rungiae pectinatae 18 parts, Herba Polygalae Chinensis 15 parts, Ramulus et folium cotini coggygriae 15 parts, Herba Lepisori Contorti 12 parts and Iris dichotoma Pall． 15 parts.
Present invention also offers the preparation method of above-mentioned Chinese medicine preparation, when the dosage form of described Chinese medicine is decoction, its preparation method comprises the following steps:
Step one: purple casserole is put in described raw medicinal material mixing, adds clear water, to clear water dipped medical material upper surface 2-5cm, soak 3-10 hour;
Step 2: purple casserole is placed on fire, after intense fire boils, using slow fire instead, to decoct the 30-50 minute dosage to medicinal liquid be slowly 100-300ml, filters, obtain filtrate a, for subsequent use;
Step 3: residue medicinal residues are added clear water again, to clear water dipped medical material upper surface 2-3cm, soaks 3-10 hour;
Step 4: be placed in by purple casserole on fire, after intense fire boils, using slow fire instead, to decoct the 25-35 minute dosage to medicinal liquid be slowly 100-300ml, filters, obtain filtrate b, mixed by filtrate a and filtrate b.
Present invention also offers the preparation method of above-mentioned Chinese medicine preparation, when the dosage form of described Chinese medicine is capsule, its preparation method comprises the following steps:
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;
3rd step, adds Pulvis Talci, magnesium stearate successively in the micropowders that second step obtains, and carries out mixing process, obtains capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.15 ~ 0.5:0.15 ~ 0.5, incapsulate in housing by described capsule 's content, obtain capsule finished product.
Below adopt embodiment to describe embodiments of the present invention in detail, fully understand how application technology means solve technical problem in the present invention whereby, reach technique effect and implement according to this.
Embodiment 1: decoction
Get Lepisorus pseudonudus Ching 18g, Herba Cheilanthes chusane 43g, Ramulus et Folium Adinae Piluliferae 12g, Radix Homonoiae Ripariae 18g, flat cattail leaf fan 13g, Cacumen et folium sageretiae 18g, Herba Asplenii Incisi 20g, Europe HUOXUEDAN 20g, Radix Camelliae sinensis 13g, Lysimachia hemsleyana 39g, Radix Cirsii Belingshanici 18g, Rhizoma Curculiginis Capitulatae 23g, Herba Lysimachiae Candidae 17g, Herba rungiae pectinatae 15g, Herba Polygalae Chinensis 20g, Ramulus et folium cotini coggygriae 12g, Herba Lepisori Contorti 18g and Iris dichotoma Pall． 12g.
Prepare according to the following steps:
Step one: purple casserole is put in described raw medicinal material mixing, adds clear water, to clear water dipped medical material upper surface 3cm, soak 5 hours;
Step 2: purple casserole is placed on fire, after intense fire boils, using slow fire instead, to decoct the 40 minutes dosage to medicinal liquid be slowly 200ml, filters, obtain filtrate a, for subsequent use;
Step 3: residue medicinal residues are added clear water again, to clear water dipped medical material upper surface 3cm, soaks 8 hours;
Step 4: be placed in by purple casserole on fire, after intense fire boils, using slow fire instead, to decoct the 35 minutes dosage to medicinal liquid be slowly 200ml, filters, obtain filtrate b, mixed by filtrate a and filtrate b.
Embodiment 2: capsule
Get Lepisorus pseudonudus Ching 140g, Herba Cheilanthes chusane 380g, Ramulus et Folium Adinae Piluliferae 140g, Radix Homonoiae Ripariae 160g, flat cattail leaf fan 190g, Cacumen et folium sageretiae 170g, Herba Asplenii Incisi 230g, Europe HUOXUEDAN 170g, Radix Camelliae sinensis 110g, Lysimachia hemsleyana 440g, Radix Cirsii Belingshanici 160g, Rhizoma Curculiginis Capitulatae 220g, Herba Lysimachiae Candidae 140g, Herba rungiae pectinatae 180g, Herba Polygalae Chinensis 150g, Ramulus et folium cotini coggygriae 150g, Herba Lepisori Contorti 120g and Iris dichotoma Pall． 150g.
Prepare according to the following steps:
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 4 times is the ethanol of 95%, reflux 2 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 90% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 2 times again, reflux 2 hours, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 2 hours, pulverize, sieve, obtain 400 object micropowders;
3rd step, adds Pulvis Talci, magnesium stearate successively in the micropowders that second step obtains, and carries out mixing process, obtains capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100:0.35:0.25, incapsulate in housing by described capsule 's content, obtain capsule finished product.
Toxicity test:
Acute toxicity testing: application mice 60, male and female half and half, body weight 20 ~ 30g, carries out acute toxicity test.Mice is divided into two groups at random, i.e. matched group and administration group, before experiment, fasting 12 hours, is dissolved in water by Chinese medicine capsules prepared by embodiments of the invention 2, (concentration is 7.28g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg (namely unit dosage form is 36.4 crude drugs/kg), and matched group gives normal saline, administration in one day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage capsule LD50>36.4 crude drug/kg of the present invention, every day, maximum dosage-feeding was 72.8 crude drugs/kg/ day.Chinese medicine preparation clinical application amount of the present invention be 6.4g crude drug/day/people, adult body weight in 60KG, average dosage is 0.107g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 25g) oral administration gavage Chinese medicine preparation of the present invention is 680 times of quantity.Therefore Chinese medicine preparation acute toxicity of the present invention is extremely low, clinical drug safety.
Long term toxicity test: Chinese medicine preparation embodiment 2 capsule of the present invention to three groups of mices (often organize 20) by 13.35, 19.26 and 38.33g crude drug/kg continuous use 15 weeks (1.0ml/100g body weight, every day 2 times) and drug withdrawal after 3 weeks, result shows: Chinese medicine preparation of the present invention is to the hair of mice, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, the indexs such as blood fat all have no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 15 weeks and drug withdrawal are after 3 weeks, Organs of Mice is all without obviously changing.Illustrate that Chinese medicine preparation of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.
Clinical data:
Case selection: whole 120 routine patients all carry out the medical patient of self-institute.Be divided into treatment group and matched group two groups at random, wherein, treatment group 60 example, man 37 example, female 23 example, 10 ~ 36 years old age.Matched group 60 example, man 35 example, female 25 example, 10 ~ 38 years old age.Two groups of patients there was no significant difference in sex, age and clinical manifestation, has comparability.
Diagnostic criteria: according to the diagnostic criteria in People's Republic of China's health industry standard it " hepatitis A diagnostic criteria " (WS298-2008) that Ministry of Public Health is issued.
Therapeutic Method:
Treatment group: diammonium glycyrrhizinate (diammonium glycyrrhizinate) 150mg, motassium magnessium aspartate 10ml add 5% glucose injection 250ml medium-sized vein drop, glucuronolatone 0.1g, Catergen .0g add 5% glucose injection 250ml medium-sized vein drop, every day 1 time, and give symptomatic treatment.Treat 2 weeks.
Treatment group: on matched group western medical treatment basis, simultaneously take the capsule of the embodiment of the present invention 2, every day 3 times, treats 2 weeks by each 3.
Curative effect judging standard: cure: clinical symptoms and sign disappear completely, liver function recovery is normal, without recurrence in 3 months.Take a turn for the better: clinical symptoms and sign disappear substantially, and liver function is clearly better.Invalid: clinical symptoms and sign do not disappear completely, bad during liver function fashion.
Therapeutic outcome: two groups treat 2 weeks respectively after, statistical result is see table 1.
Table 1 liang group treats 2 weeks Clinical efficacy comparison examples respectively
| Group | n | Cure | Take a turn for the better | Invalid | Effective percentage |
| Treatment group | 60 | 55(91.6％) | 5 | 0 | 60(100％) |
| Matched group | 60 | 45(75％) | 11 | 4 | 56(93.3％) |
As shown in Table 1, Chinese medicine of the present invention, can coordinate western medical treatment hepatitis A, better improves cure rate and effective percentage.
Concrete case: Zhao, male, 14 years old, before being admitted to hospital there is heating without inducement in patient lOd, and body temperature fluctuation, in 37.5 ~ 38.5 DEG C, occurs malaise simultaneously, and Sleep hyperhidrosis is obvious.Before 7d, there is Nausea and vomiting (gastric content) in patient, abdominal discomfort, full abdomen dull pain, yellowish urine, in Umber, with skin pruritus, without potter's clay sample just.Since idiopathy, uncomfortable without other.Through the inspection such as liver function and abdominal CT, be diagnosed as hepatitis A, on the western medicine basis of matched group, take Chinese medicine preparation embodiment 2 capsule of the present invention, each 3 examples simultaneously, every day 3 times, treat 2 weeks, clinical symptoms and sign disappear completely, and liver function recovery is normal, follow up a case by regular visits to 6 months without recurrence, cure.
The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.
Claims (9)
1. treat a Chinese medicine preparation for hepatitis A, it is characterized in that, comprise following raw medicinal material: Lepisorus pseudonudus Ching, Herba Cheilanthes chusane, Ramulus et Folium Adinae Piluliferae, Radix Homonoiae Ripariae, flat cattail leaf fan, Cacumen et folium sageretiae, Herba Asplenii Incisi, Europe HUOXUEDAN, Radix Camelliae sinensis, Lysimachia hemsleyana, Radix Cirsii Belingshanici, Rhizoma Curculiginis Capitulatae, Herba Lysimachiae Candidae, Herba rungiae pectinatae, Herba Polygalae Chinensis, Ramulus et folium cotini coggygriae, Herba Lepisori Contorti and Iris dichotoma Pall．.
2. Chinese medicine preparation as claimed in claim 1, it is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine preparation is as follows: Lepisorus pseudonudus Ching 5 ~ 20 parts, Herba Cheilanthes chusane 35 ~ 45 parts, Ramulus et Folium Adinae Piluliferae 5 ~ 15 parts, Radix Homonoiae Ripariae 10 ~ 20 parts, flat cattail leaf fan 10 ~ 25 parts, Cacumen et folium sageretiae 15 ~ 25 parts, Herba Asplenii Incisi 10 ~ 25 parts, Europe HUOXUEDAN 10 ~ 20 parts, Radix Camelliae sinensis 5 ~ 15 parts, Lysimachia hemsleyana 44 ~ 45 parts, Radix Cirsii Belingshanici 10 ~ 20 parts, Rhizoma Curculiginis Capitulatae 15 ~ 25 parts, Herba Lysimachiae Candidae 10 ~ 20 parts, Herba rungiae pectinatae 15 ~ 25 parts, Herba Polygalae Chinensis 10 ~ 25 parts, Ramulus et folium cotini coggygriae 10 ~ 20 parts, Herba Lepisori Contorti 5 ~ 20 parts and Iris dichotoma Pall． 5 ~ 15 parts.
3. Chinese medicine preparation as claimed in claim 1 or 2, it is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine preparation is as follows: Lepisorus pseudonudus Ching 10 ~ 20 parts, Herba Cheilanthes chusane 38 ~ 45 parts, Ramulus et Folium Adinae Piluliferae 10 ~ 15 parts, Radix Homonoiae Ripariae 15 ~ 20 parts, flat cattail leaf fan 10 ~ 20 parts, Cacumen et folium sageretiae 15 ~ 20 parts, Herba Asplenii Incisi 18 ~ 25 parts, Europe HUOXUEDAN 15 ~ 20 parts, Radix Camelliae sinensis 10 ~ 15 parts, Lysimachia hemsleyana 38 ~ 45 parts, Radix Cirsii Belingshanici 15 ~ 20 parts, Rhizoma Curculiginis Capitulatae 20 ~ 25 parts, Herba Lysimachiae Candidae 10 ~ 18 parts, Herba rungiae pectinatae 15 ~ 20 parts, Herba Polygalae Chinensis 10 ~ 22 parts, Ramulus et folium cotini coggygriae 10 ~ 15 parts, Herba Lepisori Contorti 10 ~ 20 parts and Iris dichotoma Pall． 10 ~ 15 parts.
4. the Chinese medicine preparation as described in claims 1 to 3, is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine preparation is as follows: Lepisorus pseudonudus Ching 18 parts, Herba Cheilanthes chusane 43 parts, Ramulus et Folium Adinae Piluliferae 12 parts, Radix Homonoiae Ripariae 18 parts, flat cattail leaf fan 13 parts, Cacumen et folium sageretiae 18 parts, Herba Asplenii Incisi 20 parts, Europe HUOXUEDAN 20 parts, Radix Camelliae sinensis 13 parts, Lysimachia hemsleyana 39 parts, Radix Cirsii Belingshanici 18 parts, Rhizoma Curculiginis Capitulatae 23 parts, Herba Lysimachiae Candidae 17 parts, Herba rungiae pectinatae 15 parts, Herba Polygalae Chinensis 20 parts, Ramulus et folium cotini coggygriae 12 parts, Herba Lepisori Contorti 18 parts and Iris dichotoma Pall． 12 parts.
5. the Chinese medicine preparation as described in claims 1 to 3, is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine preparation is as follows: Lepisorus pseudonudus Ching 14 parts, Herba Cheilanthes chusane 38 parts, Ramulus et Folium Adinae Piluliferae 14 parts, Radix Homonoiae Ripariae 16 parts, flat cattail leaf fan 19 parts, Cacumen et folium sageretiae 17 parts, Herba Asplenii Incisi 23 parts, Europe HUOXUEDAN 17 parts, Radix Camelliae sinensis 11 parts, Lysimachia hemsleyana 44 parts, Radix Cirsii Belingshanici 16 parts, Rhizoma Curculiginis Capitulatae 22 parts, Herba Lysimachiae Candidae 14 parts, Herba rungiae pectinatae 18 parts, Herba Polygalae Chinensis 15 parts, Ramulus et folium cotini coggygriae 15 parts, Herba Lepisori Contorti 12 parts and Iris dichotoma Pall． 15 parts.
6. the Chinese medicine preparation as described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is decoction, and its preparation method comprises the following steps:
Step one: purple casserole is put in described raw medicinal material mixing, adds clear water, to clear water dipped medical material upper surface 2-5cm, soak 3-10 hour;
Step 2: purple casserole is placed on fire, after intense fire boils, using slow fire instead, to decoct the 30-50 minute dosage to medicinal liquid be slowly 100-300ml, filters, obtain filtrate a, for subsequent use;
Step 3: residue medicinal residues are added clear water again, to clear water dipped medical material upper surface 2-3cm, soaks 3-10 hour;
Step 4: be placed in by purple casserole on fire, after intense fire boils, using slow fire instead, to decoct the 25-35 minute dosage to medicinal liquid be slowly 100-300ml, filters, obtain filtrate b, mixed by filtrate a and filtrate b.
7. the Chinese medicine preparation as described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is capsule, and its preparation method comprises the following steps:
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;
3rd step, adds Pulvis Talci, magnesium stearate successively in the micropowders that second step obtains, and carries out mixing process, obtains capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.15 ~ 0.5:0.15 ~ 0.5, incapsulate in housing by described capsule 's content, obtain capsule finished product.
8. a preparation method for Chinese medicine preparation described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine preparation is decoction, and its preparation method comprises the following steps:
Step one: purple casserole is put in described raw medicinal material mixing, adds clear water, to clear water dipped medical material upper surface 2-5cm, soak 3-10 hour;
Step 2: purple casserole is placed on fire, after intense fire boils, using slow fire instead, to decoct the 30-50 minute dosage to medicinal liquid be slowly 100-300ml, filters, obtain filtrate a, for subsequent use;
Step 3: residue medicinal residues are added clear water again, to clear water dipped medical material upper surface 2-3cm, soaks 3-10 hour;
Step 4: be placed in by purple casserole on fire, after intense fire boils, using slow fire instead, to decoct the 25-35 minute dosage to medicinal liquid be slowly 100-300ml, filters, obtain filtrate b, mixed by filtrate a and filtrate b.
9. a preparation method for Chinese medicine preparation described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine is capsule, and its preparation method comprises the following steps:
The first step, is mixed in proportion each for described Chinese medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;
3rd step, adds Pulvis Talci, magnesium stearate successively in the micropowders that second step obtains, and carries out mixing process, obtains capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.15 ~ 0.5:0.15 ~ 0.5, incapsulate in housing by described capsule 's content, obtain capsule finished product.
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| CN201610002414.7A Pending CN105456565A (en) | 2016-01-03 | 2016-01-03 | Traditional Chinese medicine preparation for treating hepatitis A and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106074927A (en) * | 2016-07-04 | 2016-11-09 | 胡晓峰 | A kind of Chinese medicine treating acute type A viral hepatitis and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104689137A (en) * | 2015-04-03 | 2015-06-10 | 臧海阳 | Traditional Chinese medicine composition for treating acute icteric hepatitis |
| CN104958660A (en) * | 2015-07-01 | 2015-10-07 | 陈维玉 | Traditional Chinese medicine for treating liver Qi stagnation type chronic hepatitis B and preparation method for traditional Chinese medicine |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104689137A (en) * | 2015-04-03 | 2015-06-10 | 臧海阳 | Traditional Chinese medicine composition for treating acute icteric hepatitis |
| CN104958660A (en) * | 2015-07-01 | 2015-10-07 | 陈维玉 | Traditional Chinese medicine for treating liver Qi stagnation type chronic hepatitis B and preparation method for traditional Chinese medicine |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106074927A (en) * | 2016-07-04 | 2016-11-09 | 胡晓峰 | A kind of Chinese medicine treating acute type A viral hepatitis and preparation method thereof |
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Application publication date: 20160406 |