CN106074927A - A kind of Chinese medicine treating acute type A viral hepatitis and preparation method thereof - Google Patents

A kind of Chinese medicine treating acute type A viral hepatitis and preparation method thereof Download PDF

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CN106074927A
CN106074927A CN201610520346.3A CN201610520346A CN106074927A CN 106074927 A CN106074927 A CN 106074927A CN 201610520346 A CN201610520346 A CN 201610520346A CN 106074927 A CN106074927 A CN 106074927A
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chinese medicine
herba
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胡晓峰
孙淑红
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Abstract

The invention provides a kind of Chinese medicine treating acute type A viral hepatitis and preparation method thereof, Chinese medicine includes following raw medicinal material: Scabrous Mosla Herb, Radix seu Cortex Heteropanacis Fragrantis, rouge wood, Herba Jussiaeae Repentis, Rui Liancao, Eumeces Chinensis, Herba Lysimachiae Klattianae, poly-flowers and plants, Ramulus et Folium Euryae Japonicae, Radix Inulae Cappae, chlorella, conveniently perfume, Herba Sheareriae, Brassaiopsis glomerulata (Bl.) Regel are careless, Fructus catalpae ovatae and Hylocereus undatus.Beneficial effects of the present invention: Chinese medicine of the present invention can combine doctor trained in Western medicine conventional treatment acute type A viral hepatitis, is effectively improved therapeutic effect, has no side effect, it is possible to reduces and eliminate the untoward reaction of Western medicine, and preparation technology is simple.

Description

A kind of Chinese medicine treating acute type A viral hepatitis and preparation method thereof
Technical field
The present invention relates to engineering of traditional Chinese medicine technical field, particularly relate to a kind of Chinese medicine treating acute type A viral hepatitis And preparation method thereof.
Background technology
Hepatitis A (viral hepatitis A is called for short hepatitis A), is by hepatitis A virus (HAV) Causing, based on the infectious disease of inflammation pathological changes, mainly propagated by fecal oral route, clinically with tired, appetite subtracts Moving back, hepatomegaly, abnormal liver function is main performance, and jaundice occurs in some cases, mainly shows as acute hepatitis, symptomless infection Person is common.Any age all can suffer from primary disease, but predominantly Children and teenager.The general relatively child of clinical symptoms of adult's hepatitis A is Weight.Winter-spring season is often the peak period of hepatitis A morbidity.The primary disease course of disease is self limiting, without chronicity, and the person that causes acute severe hepatitis Extremely rare, along with inactivation inactivated vaccine is controlled effectively at global use, the popular of hepatitis A.
Hepatitis A is that the acute transmitted caused by hepatitis A virus is sick, and child and teenager are common, child Hepatitis A sickness rate is only second to hepatitis B, accounts for the 17.3% of total hepatitis cases, and its Major Epidemic feature has: 1. the source of infection is to suffer from first Type hepatitis and subclinical infection person, before and after occurring with later stage incubation period and jaundice, 1 week infectiousness is the strongest.2. mainly through excrement- Mouth approach is propagated, and the infection at food and water source can cause fulminant popular.Recently report there is the case that blood and blood product are propagated. 3. after infecting, body has lasting immunity.4. clinical manifestation is acute icterohepatitis, acute anicteric hepatitis, silt gallbladder type liver Inflammation and hepatitis gravis.5. hepatitis A antibody antibody test is the foundation diagnosing this disease.6. the extensive application of Hepatitis A Vaccine Popular by effective Hepatitis a control.The morbidity of hepatitis A is how relevant with dietetic hygiene.Popular and the living conditions of hepatitis A, Hygienic habit and education degree have substantial connection, the morbidity of hepatitis A to be prevented, and in addition to paying attention to hygiene, can inoculate hepatitis A vaccine.
Summary of the invention
The technical problem to be solved is, utilizes the theory of Chinese medical science that China is traditional, it is provided that a kind of determined curative effect And the Chinese medicine and preparation method thereof of the little treatment acute type A viral hepatitis of toxic action.
In order to solve above-mentioned technical problem, the invention provides a kind of Chinese medicine treating acute type A viral hepatitis, institute State Chinese medicine and include following raw medicinal material: Scabrous Mosla Herb, Radix seu Cortex Heteropanacis Fragrantis, rouge wood, Herba Jussiaeae Repentis, Rui Liancao, Eumeces Chinensis, Herba Lysimachiae Klattianae, poly-flowers and plants, Ramulus et Folium Euryae Japonicae, Radix Inulae Cappae, chlorella, conveniently perfume, Herba Sheareriae, Brassaiopsis glomerulata (Bl.) Regel grass, Fructus catalpae ovatae and Hylocereus undatus.
The ratio of weight and number of the various raw medicinal materials in described Chinese medicine can be preferably: Scabrous Mosla Herb 20～30 parts, Radix seu Cortex Heteropanacis Fragrantis 15～25 parts, 10～20 parts of rouge wood, Herba Jussiaeae Repentis 25～35 parts, auspicious even grass 15～25 parts, Eumeces Chinensis 5～15 parts, Herba Lysimachiae Klattianae 10～ 20 parts, poly-flowers and plants 25～35 parts, Ramulus et Folium Euryae Japonicae 10～20 parts, Radix Inulae Cappae 15～25 parts, chlorella 18～28 parts, conveniently perfume 15～25 Part, Herba Sheareriae 20～30 parts, Brassaiopsis glomerulata (Bl.) Regel grass 15～25 parts, Fructus catalpae ovatae 10～20 parts and Hylocereus undatus 8～18 parts.
The ratio of weight and number of the various raw medicinal materials in described Chinese medicine can also be more preferably: Scabrous Mosla Herb 22～27 Part, Radix seu Cortex Heteropanacis Fragrantis 18～23 parts, 13～18 parts of rouge wood, Herba Jussiaeae Repentis 27～32 parts, auspicious even grass 17～22 parts, Eumeces Chinensis 8～13 parts, Huang Opening 12～17 parts, poly-flowers and plants 28～33 parts, Ramulus et Folium Euryae Japonicae 12～17 parts, Radix Inulae Cappae 20～25 parts, chlorella 20～25 parts, conveniently perfume 18～23 parts, Herba Sheareriae 23～28 parts, Brassaiopsis glomerulata (Bl.) Regel grass 17～22 parts, Fructus catalpae ovatae 15～20 parts and Hylocereus undatus 10～15 parts.
The ratio of weight and number of the various raw medicinal materials in described Chinese medicine can also be more preferably: Scabrous Mosla Herb 26 parts, big 17 parts of antidote for snake bites 19 parts, rouge wood, Herba Jussiaeae Repentis 28 parts, auspicious even grass 21 parts, Eumeces Chinensis 8 parts, Herba Lysimachiae Klattianae 16 parts, poly-flowers and plants 29 parts, Ramulus et Folium Euryae Japonicae 16 parts, Radix Inulae Cappae 20 parts, chlorella 23 parts, the most fragrant 20 parts, Herba Sheareriae 27 parts, Brassaiopsis glomerulata (Bl.) Regel grass 18 parts, Fructus catalpae ovatae 20 parts and Hylocereus undatus 10 parts.
The ratio of weight and number of the various raw medicinal materials in described Chinese medicine can also be more preferably: Scabrous Mosla Herb 22 parts, big 14 parts of antidote for snake bites 22 parts, rouge wood, Herba Jussiaeae Repentis 31 parts, auspicious even grass 18 parts, Eumeces Chinensis 12 parts, Herba Lysimachiae Klattianae 12 parts, poly-flowers and plants 32 parts, Ramulus et Folium Euryae Japonicae 14 parts, Radix Inulae Cappae 24 parts, chlorella 20 parts, the most fragrant 22 parts, Herba Sheareriae 25 parts, Brassaiopsis glomerulata (Bl.) Regel grass 22 parts, Fructus catalpae ovatae 16 parts and Hylocereus undatus 15 parts.
When the dosage form of described Chinese medicine is powder, its preparation method comprises the following steps:
The first step, is mixed in proportion described raw medicinal material, is ground into powder；
Second step, obtains the first step powder and adds immersion 6 hours～12 hours in cold water, with slow fire boiling, during decoction Between be 3 hours～5 hours, by decoction liquor filter, it is thus achieved that the first filtrate, the quality of the water added be the first step obtain powder 2～4 times of quality；
3rd step, filters, by second step, the filtering residue obtained and again adds in cold water, with slow fire boiling 2 hours～4 hours, mistake Filter obtains the second filtrate, and the quality of the water added is 2～4 times of the powder quality that second step obtains；
The second filtrate mixing that 4th step, the first filtrate obtained by second step and the 3rd step obtain, concentrating under reduced pressure removes Water, dry, pulverize into powder, and granularity is 80～120 mesh；
5th step, in the powder that described 4th step obtains, adds starch, described starch weight hundred in described powder Proportion by subtraction is 15%～30%, and by the material pouch after mixing or packing box subpackage, every 5～10 grams is one bag or a box subpackage.
When the dosage form of described Chinese medicine is decoction, its preparation method comprises the following steps:
Step one: the mixing of described raw medicinal material is put in purple casserole, adds clear water, to clear water dipped medical material upper surface 2- 5cm, soaks 3-10 hour；
Step 2: be placed on fire by purple casserole, after intense fire boils, uses slow fire instead and decocts the 30-50 minute dosage to medicinal liquid slowly For 100-300ml, filter, obtain filtrate a, standby；
Step 3: residue medicinal residues are added clear water again, to clear water dipped medical material upper surface 2-3cm, soaks 3-10 hour；
Step 4: be placed on fire by purple casserole, after intense fire boils, uses slow fire instead and decocts the 25-35 minute dosage to medicinal liquid slowly For 100-300ml, filter, obtain filtrate b, filtrate a and filtrate b is mixed.
Beneficial effects of the present invention: Chinese medicine of the present invention can combine doctor trained in Western medicine conventional treatment acute Alphavirus liver Inflammation, is effectively improved therapeutic effect, has no side effect, it is possible to reduce and eliminate the untoward reaction of Western medicine, and preparation technology is simple.
Detailed description of the invention
The invention provides a kind of Chinese medicine treating acute type A viral hepatitis, Chinese medicine includes following raw medicinal material: Scabrous Mosla Herb, Radix seu Cortex Heteropanacis Fragrantis, rouge wood, Herba Jussiaeae Repentis, Rui Liancao, Eumeces Chinensis, Herba Lysimachiae Klattianae, poly-flowers and plants, Ramulus et Folium Euryae Japonicae, Radix Inulae Cappae, chlorella, conveniently Perfume, Herba Sheareriae, Brassaiopsis glomerulata (Bl.) Regel grass, Fructus catalpae ovatae and Hylocereus undatus, Rhizoma soulieae vaginatae, Lignum cinnamomi camphorae and Herba Lysimachiae Grammicae.
The pharmacology of various raw medicinal materials is as follows:
Scabrous Mosla Herb: [another name] ghost Oleum sesami, Mosla dianthera, thinleaf glossogyne herb, wild catmint, miliaria grass, Herba Chenopodii, wild Herba Glossogynes tenuifoliae, miliaria alba Grass, Rhizoma et radix valerianae, wild mustard, white crane grass, sky Oleum sesami, Herba Moslae Soochowensis, Origanum vulgare Linn., pale reddish brown grass.[source] medical material Ji Yuan: for labiate The herb of Scabrous Mosla Herb.[nature and flavor] acrid in the mouth；Bitter；Cool in nature.[function cures mainly] dispelling wind to relieve the exterior syndrome；Clearing away summer-heat is except temperature；Detoxifying and relieving itching.Main flu head Bitterly；Cough；Heatstroke；Rubella is scorching；Dysentery；Hemorrhoidal bleeding；Metrorrhagia；Miliaria alba；Eczema；Limb tinea；Snake bite and insect sting.[extracts] " China's book on Chinese herbal medicine "
Radix seu Cortex Heteropanacis Fragrantis: [another name] slender acanthopanax is logical, granny's umbrella.[source] medical material Ji Yuan: for root, the bark of Araliaceae heavy curtain umbrella maple Or leaf.[nature and flavor] bitter in the mouth；Cool in nature.[function cures mainly] removing pathogenic heat from blood and toxic substance from the body；Reducing swelling and alleviating pain.Main cold, fever；Heatstroke is had a headache；Carbuncle furuncle and phyma Poison；Scrofula；Rheumatic arthralgia；Traumatic injury；Venom.[extracts] " China's book on Chinese herbal medicine "
Rouge wood: [source] medical material Ji Yuan: hang upside down root or the stem of pen for apocynaceae plant hair.[nature and flavor] micro-hardship；Cool in nature. [function cures mainly] removing toxic substances and promoting subsidence of swelling.Main venom.[extracts] " China's book on Chinese herbal medicine "
Herba Jussiaeae Repentis: [another name] water cover dish, collapse silver hair pin in grass, grass, white jade hairpin hairpin careless, beautiful grass, water jar dish, Caulis Entadae, water mustard Dish, Shui Caiyue, Canis familiaris L. intestinal grass, Phyla nodiflora, Folium Eriobotryae dish, Air Bladder pseudosciaenae seu Acipenser are careless, water floats rattan, cross ditch dragon, cross pool mark Herba Polygoni japonici, water big belly dish, vacation urn Dish.[source] medical material Ji Yuan: for the herb of the onagraceae plant fire hose.[nature and flavor] bitter in the mouth；Micro-sweet；Cold in nature.[function cures mainly] is clear Heat；Diuresis；Removing toxic substances.Main cold, fever；Cough caused by dryness-heat；High hot excessive thirst；Drench pain；Edema；Pharyngalgia；Larynx swells；Aphtha；Acute toothache； Carbuncle sore furuncle swells；Burn and scald；Traumatic injury wound is swollen；Poisonous snake；Lyssodexis.[extracts] " China's book on Chinese herbal medicine "
Auspicious even grass: [another name] Flos Chrysanthemi, soil Radix Bupleuri, Kowloon arrow, Aster subulatus.[source] medical material Ji Yuan: for feverfew Bore the herb of leaf Radix Asteris.[nature and flavor] bitter in the mouth；Acid；Cool in nature.[function cures mainly] heat-clearing and toxic substances removing.Main carbuncle；Eczema.[extracts] " China Book on Chinese herbal medicine "
Eumeces Chinensis: [another name] lizard Yi easy, easy, Eremiatis argi, Eumeces Chinensis, Gekko Swinhonis, stone Yi, pig Laticauda semifasciata, Japalurae, five cun of rods.[come Source] it is Scincidae animal Eumeces Chinensis or the entirety of Eumeces elegans Boulenger removing internal organs.[nature and flavor] salty in the mouth；Cold in nature.[function cures mainly] Relieving stranguria by diuresis；Broken knot dissipating blood stasis；Removing toxic substances.The main difficulty in urination；Stranguria caused by urinary stone；Dysuria；Malignant boil；Ecthyma；Scrofula.[extracts] " China's book on Chinese herbal medicine "
Spun gold brush: [another name] Cladonia fallax Abbayes.[source] medical material Ji Yuan: for the thallus of Parmeliaceae plant spun gold brush.[nature and flavor] Bitter；Property flat.[return through] heart；Liver Channel.[function cures mainly] calms the nerves；Suppressing the hyperactive liver；Invigorate blood circulation；Sore.Main insomnia；Epilepsy；Dizziness；Traumatic injury damages Wound；Burn due to hot liquid or fire.[extracts] " China's book on Chinese herbal medicine "
Herba Lysimachiae Klattianae: [another name] tiger footprint is careless, see blood lives.[source] medical material Ji Yuan: pass by one's way for Ofthe Primulaceae wheel blade Yellow herb.[nature and flavor] are bitter；Puckery；Cold nature.[return through] spleen；Liver Channel.[function cures mainly] cooling blood for hemostasis；Suppressing the hyperactive liver；Antidote against snake bite.Master coughs up Blood；Spit blood；Epistaxis；Have blood in stool；Traumatic hemorrhage；Insomnia；Hypertension；Venom.[extracts] " China's book on Chinese herbal medicine "
Poly-flowers and plants: [another name] Phyllostachys congesta dish, water DABUSI, Herba Murdanniae Triquetrae grass, Folium Bambusae rattan, pool mussel, excessively river bamboo.[source] medical material Ji Yuan: for the herb of the poly-flowers and plants of Commelianaceae plant.[nature and flavor] are bitter；Cool.[function cures mainly] clearing away heat and promoting diuresis；Removing toxic substances.Main lung-heat is coughed Cough；Conjunctival congestion and swelling pain；Stranguria；Edema；Furuncle toxic swelling.[extracts] " China's book on Chinese herbal medicine "
Ramulus et Folium Euryae Japonicae: [another name] is blown wood leaf, spire dish, fished Fructus Solani melongenae, spire tea.[source] medical material Ji Yuan: for plant of theaceae Eurya plant The branch and leaf of wood or fruit.[nature and flavor] are bitter；Puckery；Cool.[return through] spleen；Bladder warp.[function cures mainly] expelling wind and clearing away heat；Inducing diuresis to remove edema；Only Blood granulation promoting.Main air pain of dampness syndrome；Ascites expands；Heating xerostomia；Skin ulcer swells；Treating swelling and pain by traumatic injury；Wound hemorrhage.[extracts] " China's book on Chinese herbal medicine "
Radix Inulae Cappae: [another name] Inula cappa (Ham.) DC., the soil Radix Angelicae Dahuricae (" the SHENGCAO property of medicine is standby to be wanted "), (" investigation report planted by Kunming medicine to black GUFENG Accuse "), Herba Aristolochiae Mollissimae, iron are fragrant (" Traditional Chinese Medicine in Sichuan will "), Herba Inulae cappae root (" Quanzhou book on Chinese herbal medicine ").[source] is feverfew Herba Inulae cappae Root.Excavate after the Beginning of summer.[nature and flavor] are pungent, temperature.[function cures mainly] expelling wind and cold, relaxing muscles and tendons to promote blood circulation.Control anemofrigid cold, cough, asthma, Rheumatic arthralgia, menoxenia.[extracts] " Chinese medicine voluminous dictionary "
Chlorella: [source] medical material Ji Yuan: for chlorella section vegetable protein core chlorella and the frond of chlorella.[function Cure mainly] clearing away heat and promoting diuresis；Enrich blood.Main edema；Have loose bowels；Hepatitis；Anemia.[extracts] " China's book on Chinese herbal medicine "
Conveniently perfume: [another name] wash one's hands perfume (or spice), band hands is fragrant, roadside is fragrant, Rhizoma Kaempferiae perfume.[source] Acorus of Araceae plant is conveniently Perfume (or spice), with all herbal medicine.The four seasons can adopt, and dries.[nature and flavor] are pungent, temperature.[function cures mainly] promoting the circulation of QI to relieve pain, dispel the wind by cold, and detoxify diuretic, Eliminate phlegm for resuscitation.For mental confusion due to phlegm, coma, gnathospasma, stomachache uncomfortable in chest, turbid damp obstructing in middle-JIAO, rheumatic arthritis, colic, water Swollen；Innominate toxic swelling is controlled in external.[extracts] " whole nation Chinese herbal medicine compilation "
Herba Sheareriae: [another name] green and green grass, Ephedra sinica.[source] medical material Ji Yuan: for the herb of feverfew Herba Sheareriae.[property Taste] bitter in the mouth；Property flat.[function cures mainly] heat-clearing and toxic substances removing；Inducing diuresis to remove edema.Main sore swollen toxin；Edema；Headache due to pathogenic wind-heat.[extracts] " China Book on Chinese herbal medicine "
Brassaiopsis glomerulata (Bl.) Regel grass: [another name] Rhizoma Arisaematis, little fireworks display, big Herba Mimosae Pudicae, pocket grass, parachute.[source] medical material Ji Yuan: for jealous woman The herb of Jiang Cao section plant Biophytum nanum H. Chuang sp. Nov. Ined.-B. Sensitivum auct. Non (L.) DC..[nature and flavor] are sweet；Micro-hardship；Flat.[return through] lung；Bladder warp.[function cures mainly] eliminating phlegm to relieve asthma；Disappear Long-pending diuretic.Main asthma；Infantile malnutrition；Edema；Stranguria with turbid discharge.[extracts] " China's book on Chinese herbal medicine "
Fructus catalpae ovatae: [source] medical material Ji Yuan: for the fruit of Bignoniaceae plant Chinese catalpa.[nature and flavor] sweet in the mouth；Property flat.[return through] kidney；Wing Guang warp.[function cures mainly] inducing diuresis to remove edema.Main dysuria；Edema；Ascites.[extracts] " China's book on Chinese herbal medicine "
Hylocereus undatus: [source] medical material Ji Yuan: for the stem of Cactaeous plants Hylocereus undatus.[nature and flavor] are sweet；Light；Cool in nature.[function Cure mainly] relaxing muscles and tendons and activating QI and blood in the collateral；Removing toxic substances and promoting subsidence of swelling.Main injury and bone fracture；Mumps；Skin ulcer swells；Burn and scald.[extracts] " China's book on Chinese herbal medicine "
The ratio of weight and number of the various raw medicinal materials in described Chinese medicine can be preferably: Scabrous Mosla Herb 20～30 parts, Radix seu Cortex Heteropanacis Fragrantis 15～25 parts, 10～20 parts of rouge wood, Herba Jussiaeae Repentis 25～35 parts, auspicious even grass 15～25 parts, Eumeces Chinensis 5～15 parts, Herba Lysimachiae Klattianae 10～ 20 parts, poly-flowers and plants 25～35 parts, Ramulus et Folium Euryae Japonicae 10～20 parts, Radix Inulae Cappae 15～25 parts, chlorella 18～28 parts, conveniently perfume 15～25 Part, Herba Sheareriae 20～30 parts, Brassaiopsis glomerulata (Bl.) Regel grass 15～25 parts, Fructus catalpae ovatae 10～20 parts and Hylocereus undatus 8～18 parts.
The ratio of weight and number of the various raw medicinal materials in described Chinese medicine can also be more preferably: Scabrous Mosla Herb 22～27 Part, Radix seu Cortex Heteropanacis Fragrantis 18～23 parts, 13～18 parts of rouge wood, Herba Jussiaeae Repentis 27～32 parts, auspicious even grass 17～22 parts, Eumeces Chinensis 8～13 parts, Huang Opening 12～17 parts, poly-flowers and plants 28～33 parts, Ramulus et Folium Euryae Japonicae 12～17 parts, Radix Inulae Cappae 20～25 parts, chlorella 20～25 parts, conveniently perfume 18～23 parts, Herba Sheareriae 23～28 parts, Brassaiopsis glomerulata (Bl.) Regel grass 17～22 parts, Fructus catalpae ovatae 15～20 parts and Hylocereus undatus 10～15 parts.
The ratio of weight and number of the various raw medicinal materials in described Chinese medicine can also be more preferably: Scabrous Mosla Herb 26 parts, big 17 parts of antidote for snake bites 19 parts, rouge wood, Herba Jussiaeae Repentis 28 parts, auspicious even grass 21 parts, Eumeces Chinensis 8 parts, Herba Lysimachiae Klattianae 16 parts, poly-flowers and plants 29 parts, Ramulus et Folium Euryae Japonicae 16 parts, Radix Inulae Cappae 20 parts, chlorella 23 parts, the most fragrant 20 parts, Herba Sheareriae 27 parts, Brassaiopsis glomerulata (Bl.) Regel grass 18 parts, Fructus catalpae ovatae 20 parts and Hylocereus undatus 10 parts.
The ratio of weight and number of the various raw medicinal materials in described Chinese medicine can also be more preferably: Scabrous Mosla Herb 22 parts, big 14 parts of antidote for snake bites 22 parts, rouge wood, Herba Jussiaeae Repentis 31 parts, auspicious even grass 18 parts, Eumeces Chinensis 12 parts, Herba Lysimachiae Klattianae 12 parts, poly-flowers and plants 32 parts, Ramulus et Folium Euryae Japonicae 14 parts, Radix Inulae Cappae 24 parts, chlorella 20 parts, the most fragrant 22 parts, Herba Sheareriae 25 parts, Brassaiopsis glomerulata (Bl.) Regel grass 22 parts, Fructus catalpae ovatae 16 parts and Hylocereus undatus 15 parts.
When the dosage form of described Chinese medicine is powder, and it comprises the following steps:
The first step, is mixed in proportion described raw medicinal material, is ground into powder；
Second step, obtains the first step powder and adds immersion 6 hours～12 hours in cold water, with slow fire boiling, during decoction Between be 3 hours～5 hours, by decoction liquor filter, it is thus achieved that the first filtrate, the quality of the water added be the first step obtain powder 2～4 times of quality；
3rd step, filters, by second step, the filtering residue obtained and again adds in cold water, with slow fire boiling 2 hours～4 hours, mistake Filter obtains the second filtrate, and the quality of the water added is 2～4 times of the powder quality that second step obtains；
The second filtrate mixing that 4th step, the first filtrate obtained by second step and the 3rd step obtain, concentrating under reduced pressure removes Water, dry, pulverize into powder, and granularity is 80～120 mesh；
5th step, in the powder that described 4th step obtains, adds starch, described starch weight hundred in described powder Proportion by subtraction is 15%～30%, and by the material pouch after mixing or packing box subpackage, every 5～10 grams is one bag or a box subpackage.
When the dosage form of described Chinese medicine is decoction, and it comprises the following steps:
Step one: the mixing of described raw medicinal material is put in purple casserole, adds clear water, to clear water dipped medical material upper surface 2- 5cm, soaks 3-10 hour；
Step 2: be placed on fire by purple casserole, after intense fire boils, uses slow fire instead and decocts the 30-50 minute dosage to medicinal liquid slowly For 100-300ml, filter, obtain filtrate a, standby；
Step 3: residue medicinal residues are added clear water again, to clear water dipped medical material upper surface 2-3cm, soaks 3-10 hour；
Step 4: be placed on fire by purple casserole, after intense fire boils, uses slow fire instead and decocts the 25-35 minute dosage to medicinal liquid slowly For 100-300ml, filter, obtain filtrate b, filtrate a and filtrate b is mixed.
Embodiment is below used to describe embodiments of the present invention in detail, whereby to the present invention how application technology means Solve technical problem, and the process that realizes reaching technique effect can fully understand and implement according to this.
Embodiment 1: powder
Take Scabrous Mosla Herb 220g, Radix seu Cortex Heteropanacis Fragrantis 220g, rouge wood 140g, Herba Jussiaeae Repentis 310g, auspicious even grass 180g, Eumeces Chinensis 120g, Huang Opening 120g, poly-flowers and plants 320g, Ramulus et Folium Euryae Japonicae 140g, Radix Inulae Cappae 240g, chlorella 200g, the most fragrant 220g, Herba Sheareriae 250g, Brassaiopsis glomerulata (Bl.) Regel Grass 220g, Fructus catalpae ovatae 160g and Hylocereus undatus 150g.
Its preparation method comprises the following steps:
The first step, is mixed in proportion described raw medicinal material, is ground into powder；
Second step, obtains the first step powder and adds in cold water and soak 8 hours, and with slow fire boiling, decocting time is 5 little Time, decoction liquor being filtered, it is thus achieved that the first filtrate, the quality of the water added is 3 times of the powder quality that the first step obtains；
3rd step, filters, by second step, the filtering residue obtained and again adds in cold water, with slow fire boiling 3 hours, filters and obtains Second filtrate, the quality of the water added is 2 times of the powder quality that second step obtains；
The second filtrate mixing that 4th step, the first filtrate obtained by second step and the 3rd step obtain, concentrating under reduced pressure removes Water, dry, pulverize into powder, and granularity is 100 mesh；
5th step, in the powder that described 4th step obtains, adds starch, described starch weight hundred in described powder Proportion by subtraction is 20%, and by the material pouch box subpackage after mixing, every 10 grams is one bag of subpackage.
Embodiment 2: decoction
Take Scabrous Mosla Herb 260g, Radix seu Cortex Heteropanacis Fragrantis 190g, rouge wood 170g, Herba Jussiaeae Repentis 280g, auspicious even grass 210g, Eumeces Chinensis 80g, Huang Kai Mouth 160g, poly-flowers and plants 290g, Ramulus et Folium Euryae Japonicae 160g, Radix Inulae Cappae 200g, chlorella 230g, the most fragrant 200g, Herba Sheareriae 270g, Brassaiopsis glomerulata (Bl.) Regel grass 180g, Fructus catalpae ovatae 200g and Hylocereus undatus 100g.
Its preparation method comprises the following steps:
Step one: the mixing of described raw medicinal material is put in purple casserole, adds clear water, to clear water dipped medical material upper surface 2cm, soaks 5 hours；
Step 2: be placed on fire by purple casserole, after intense fire boils, uses slow fire instead and decocts the 40 minutes dosage to medicinal liquid slowly and be 200ml, filters, obtains filtrate a, standby；
Step 3: residue medicinal residues are added clear water again, to clear water dipped medical material upper surface 2cm, soaks 5 hours；
Step 4: be placed on fire by purple casserole, after intense fire boils, uses slow fire instead and decocts the 30 minutes dosage to medicinal liquid slowly and be 100ml, filters, obtains filtrate b, mixed by filtrate a and filtrate b.
Toxicity test:
Acute toxicity testing: application mice 60, male and female half and half, body weight 20～32g, carries out acute toxicity test.Mice It is randomly divided into two groups, i.e. matched group and administration group, fasting 12 hours, the powder of Chinese traditional medicine prepared by embodiments of the invention 1 before experiment Agent is dissolved in water, and (concentration is 8.72g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg (i.e. single-dose agent Amount is 43.6 crude drugs/kg), matched group gives normal saline, within one day, is administered 2 times, and delivery time 6 hours, after administration Continuous Observation 14 days, and record mice toxic reaction and death toll.Test result indicate that: compare with matched group, after administration Mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase the most normal.Mice Powder LD50 > 43.6 crude drugs/the kg of the oral administration gavage present invention, every day, maximum dosage-feeding was 87.2 crude drugs/kg/ day.The present invention's Chinese medicine clinical application amount is 7.8g crude drug/day/people, and adult's body weight is in terms of 60KG, and average dosage is 0.13g crude drug/kg/ Day.By weighing machine: the dosis tolerata of the Chinese medicine of mice (average weight is in terms of 26g) the oral administration gavage present invention as quantity 671 Times.Therefore the Chinese medicine acute toxicity of the present invention is extremely low, clinical drug safety.
Long term toxicity test: three groups of mices (often group 20) are pressed 13.25,25.34 and by Chinese medicine embodiment 1 powder of the present invention After 41.52g crude drug/kg continuous use 15 weeks (1.0ml/100g body weight, every day 2 times) and drug withdrawal 3 weeks, result shows: the present invention Chinese medicine is to equal nothings of index such as the hair of mice, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat Significantly affecting, internal organs naked eyes do not find that difference change and histological indications show, after medication 15 weeks and drug withdrawal 3 weeks, little The each internal organs of Mus are all without substantially changing.Illustrate that Chinese medicine of the present invention is little to toxicity after mice long-term prescription, after drug withdrawal, also do not have difference anti- Should, application safety.
Clinical data:
Case selection: all 90 example cases derive from this Out-patient Department and the acute type A viral hepatitis patient being in hospital. All patients are randomly divided into two groups, treatment group and each 45 examples of matched group.In treatment group 45 example, male 26 examples, female 19 example, the age 6 ～51 years old；Companion's jaundice person 20 example.In matched group 45 example, male 27 examples, female 18 example, age 7～52 years old；Companion's jaundice person 19 example.Treatment Group compares no significant difference with matched group patient at aspects such as sex, age and clinical symptoms, has comparability.
Diagnostic criteria: with reference to acute first in " clinical disease diagnosis and curative effect judging standard " that hospital associate of Hunan Province writes The diagnostic criteria of type hepatitis.One, suspected case: 1, epidemiology: premorbid is eaten unclean food history for 45 days or drinks unclean unboiled water Or with acute hepatitis A contact history.2, symptom: the heating without other reasons, weak, appetite decline, Nausea and vomiting etc. occur for nearly 1 week Symptom of digestive tract, can have sclera, xanthochromia.3, sign: liver enlargement, with touching a tender spot or kowtowing pain.4, liver function test: 1. paddy Pyruvic transaminase (ATL) is substantially abnormal；2. serum total bilirubin ＞ 17 μm ol/L, urine bilirubin is positive；As long as having symptom and liver function In checking, an exception can Diagnosis of Suspected case.5, clinical manifestation and lab testing: TBIL ＜ 17mol/L person is diagnosed as Acute anicteric hepatitis.Skin yellow sclera person, TBIL ＞ 17mol/L person is had to be diagnosed as acute icterohepatitis.Two, make a definite diagnosis Case: meet suspected case diagnostic criteria and the anti-HAVIgM of serum is positive, or 4 times of rising persons of anti-HAVIgM.
Therapeutic Method:
Matched group: use western medicine routine treatment, including isolating, lie up, give light light diet, supplementing in right amount Vitamin C and vitamin B complex, diammonium glycyrrhizinate injection 150mg add 5% glucose injection 250ml iv drip and right Disease is treated；Within 1 week, it is a course for the treatment of, treats two courses for the treatment of.
Treatment group: on the basis for the treatment of of control group, oral Chinese medicine embodiment 1 powder of the present invention, each 20g, three times a day；1 Zhou Weiyi the course for the treatment of, treat two courses for the treatment of.
Curative effect judging standard: (1) cures: clinical symptoms and sign disappear, and liver function recovery is normal.(2) effective: clinical condition Shape and sign substantially disappear or substantially alleviate, and liver function takes a turn for the better.(3) invalid: clinical symptoms, sign are not improved, liver function Unchanged or increase the weight of.
Therapeutic outcome: after two groups are treated 2 weeks respectively, statistical result sees table 1.
Clinical efficacy comparison (unit: example) after treating respectively 2 weeks organized by 1 liang of table
Group Number of cases Cure Effectively Invalid Total effective rate
Treatment group 45 38 6 1 44 (97.7%)
Matched group 45 32 7 6 39 (86.7%)
As it can be seen from table 1 treatment group uses the Chinese medicine of the present invention, coordinate western medical treatment acute type A viral hepatitis, Relative to matched group, on therapeutic effect, have and be markedly improved.
Untoward reaction: matched group 45 example patient, in therapeutic process, there is the gastrointestinal upset such as Nausea and vomiting, abdominal distention in 8 examples, 3 There is headache, dizziness in example, and xerostomia occurs in 1 example, hepatic and renal function injure or other untoward reaction does not all occur.Treatment group group 45 example is suffered from , in therapeutic process, all there is not hepatic and renal function injure, gastrointestinal upset or other untoward reaction in person.
Concrete case: Song, man, 12 years old, patient occurred that in the case of without obvious inducement Nausea and vomiting, low grade fever accompany sclera Xanthochromia, is carried by father and mother and sees a doctor to the court, be diagnosed as acute type A viral hepatitis through liver function and lab testing etc., and it is right to give According to group western medicine routine treatment, of the present invention Chinese medicine embodiment 1 powder being administered orally simultaneously, treats 1 week, clinical symptoms and sign disappear, liver Functional rehabilitation is normal, cures, and follows up a case by regular visits to 3 months without recurrence.
The above, be only presently preferred embodiments of the present invention, is not the restriction that the present invention makees other form, appoints What those skilled in the art changed possibly also with the technology contents of the disclosure above or be modified as equivalent variations etc. Effect embodiment.But every without departing from technical solution of the present invention content, the technical spirit of the foundation present invention is to above example institute Any simple modification, equivalent variations and the remodeling made, still falls within the protection domain of technical solution of the present invention.

Claims (9)

1. the Chinese medicine treating acute type A viral hepatitis, it is characterised in that described Chinese medicine includes following raw medicinal material: stone Shepherd's purse ramie, Radix seu Cortex Heteropanacis Fragrantis, rouge wood, Herba Jussiaeae Repentis, Rui Liancao, Eumeces Chinensis, Herba Lysimachiae Klattianae, poly-flowers and plants, Ramulus et Folium Euryae Japonicae, Radix Inulae Cappae, chlorella, conveniently Perfume, Herba Sheareriae, Brassaiopsis glomerulata (Bl.) Regel grass, Fructus catalpae ovatae and Hylocereus undatus.
2. Chinese medicine as claimed in claim 1, it is characterised in that the ratio of weight and number of described raw medicinal material is: Scabrous Mosla Herb 20～ 30 parts, Radix seu Cortex Heteropanacis Fragrantis 15～25 parts, 10～20 parts of rouge wood, Herba Jussiaeae Repentis 25～35 parts, auspicious the most careless 15～25 parts, Eumeces Chinensis 5～15 parts, Herba Lysimachiae Klattianae 10～20 parts, poly-flowers and plants 25～35 parts, Ramulus et Folium Euryae Japonicae 10～20 parts, Radix Inulae Cappae 15～25 parts, chlorella 18～28 parts, conveniently Fragrant 15～25 parts, Herba Sheareriae 20～30 parts, Brassaiopsis glomerulata (Bl.) Regel grass 15～25 parts, Fructus catalpae ovatae 10～20 parts and Hylocereus undatus 8～18 parts.
3. Chinese medicine as claimed in claim 1 or 2, it is characterised in that the ratio of weight and number of described raw medicinal material is: Scabrous Mosla Herb 22 ～27 parts, Radix seu Cortex Heteropanacis Fragrantis 18～23 parts, 13～18 parts of rouge wood, Herba Jussiaeae Repentis 27～32 parts, auspicious even 17～22 parts, Eumeces Chinensis 8～13 of grass Part, Herba Lysimachiae Klattianae 12～17 parts, poly-flowers and plants 28～33 parts, Ramulus et Folium Euryae Japonicae 12～17 parts, Radix Inulae Cappae 20～25 parts, chlorella 20～25 parts, Conveniently fragrant 18～23 parts, Herba Sheareriae 23～28 parts, Brassaiopsis glomerulata (Bl.) Regel grass 17～22 parts, Fructus catalpae ovatae 15～20 parts and Hylocereus undatus 10～15 parts.
4. the Chinese medicine as described in claims 1 to 3, it is characterised in that the ratio of weight and number of described raw medicinal material is: Scabrous Mosla Herb 26 Part, 17 parts of Radix seu Cortex Heteropanacis Fragrantis 19 parts, rouge wood, Herba Jussiaeae Repentis 28 parts, auspicious even grass 21 parts, Eumeces Chinensis 8 parts, Herba Lysimachiae Klattianae 16 parts, poly-flowers and plants 29 parts, Ramulus et Folium Euryae Japonicae 16 parts, Radix Inulae Cappae 20 parts, chlorella 23 parts, the most fragrant 20 parts, Herba Sheareriae 27 parts, Brassaiopsis glomerulata (Bl.) Regel grass 18 parts, Fructus catalpae ovatae 20 parts and amount It chi 10 parts.
5. the Chinese medicine as described in Claims 1-4, it is characterised in that the ratio of weight and number of described raw medicinal material is: Scabrous Mosla Herb 22 Part, 14 parts of Radix seu Cortex Heteropanacis Fragrantis 22 parts, rouge wood, Herba Jussiaeae Repentis 31 parts, auspicious even grass 18 parts, Eumeces Chinensis 12 parts, Herba Lysimachiae Klattianae 12 parts, poly-flowers and plants 32 Part, Ramulus et Folium Euryae Japonicae 14 parts, Radix Inulae Cappae 24 parts, chlorella 20 parts, conveniently fragrant 22 parts, Herba Sheareriae 25 parts, Brassaiopsis glomerulata (Bl.) Regel grass 22 parts, Fructus catalpae ovatae 16 parts and Hylocereus undatus 15 parts.
6. the Chinese medicine as described in claim 1 to 5, it is characterised in that the dosage form of described Chinese medicine is powder, and its preparation method includes Following steps:
The first step, is mixed in proportion described raw medicinal material, is ground into powder；
Second step, obtains the first step powder and adds immersion 6 hours～12 hours in cold water, and with slow fire boiling, decocting time is 3 Hour～5 hours, by decoction liquor filter, it is thus achieved that the first filtrate, the quality of the water added be the first step obtain powder quality 2～4 times；
3rd step, filters, by second step, the filtering residue obtained and again adds in cold water, and with slow fire boiling 2 hours～4 hours, filtration obtained Obtaining the second filtrate, the quality of the water added is 2～4 times of the powder quality that second step obtains；
The second filtrate mixing that 4th step, the first filtrate obtained by second step and the 3rd step obtain, concentrating under reduced pressure removes water, dry Dry, it is ground into powder, granularity is 80～120 mesh；
5th step, in the powder that described 4th step obtains, adds starch, described starch percentage by weight in described powder Being 15%～30%, by the material pouch after mixing or packing box subpackage, every 5～10 grams is one bag or a box subpackage.
7. the Chinese medicine as described in claim 1 to 5, it is characterised in that the dosage form of described Chinese medicine is decoction, and its preparation method includes Following steps:
Step one: the mixing of described raw medicinal material is put in purple casserole, adds clear water, to clear water dipped medical material upper surface 2-5cm, Soak 3-10 hour；
Step 2: be placed on fire by purple casserole, after intense fire boils, uses slow fire instead and decocts the 30-50 minute dosage to medicinal liquid slowly and be 100-300ml, filters, obtains filtrate a, standby；
Step 3: residue medicinal residues are added clear water again, to clear water dipped medical material upper surface 2-3cm, soaks 3-10 hour；
Step 4: be placed on fire by purple casserole, after intense fire boils, uses slow fire instead and decocts the 25-35 minute dosage to medicinal liquid slowly and be 100-300ml, filters, obtains filtrate b, mixed by filtrate a and filtrate b.
8. the preparation method of the Chinese medicine described in a claim 1 to 5, it is characterised in that the dosage form of described Chinese medicine is powder, its Comprise the following steps:
The first step, is mixed in proportion described raw medicinal material, is ground into powder；
Second step, obtains the first step powder and adds immersion 6 hours～12 hours in cold water, and with slow fire boiling, decocting time is 3 Hour～5 hours, by decoction liquor filter, it is thus achieved that the first filtrate, the quality of the water added be the first step obtain powder quality 2～4 times；
3rd step, filters, by second step, the filtering residue obtained and again adds in cold water, and with slow fire boiling 2 hours～4 hours, filtration obtained Obtaining the second filtrate, the quality of the water added is 2～4 times of the powder quality that second step obtains；
The second filtrate mixing that 4th step, the first filtrate obtained by second step and the 3rd step obtain, concentrating under reduced pressure removes water, dry Dry, it is ground into powder, granularity is 80～120 mesh；
5th step, in the powder that described 4th step obtains, adds starch, described starch percentage by weight in described powder Being 15%～30%, by the material pouch after mixing or packing box subpackage, every 5～10 grams is one bag or a box subpackage.
9. the preparation method of the Chinese medicine described in a claim 1 to 5, it is characterised in that the dosage form of described Chinese medicine is decoction, its Preparation method comprises the following steps:
Step one: the mixing of described raw medicinal material is put in purple casserole, adds clear water, to clear water dipped medical material upper surface 2-5cm, Soak 3-10 hour；
Step 2: be placed on fire by purple casserole, after intense fire boils, uses slow fire instead and decocts the 30-50 minute dosage to medicinal liquid slowly and be 100-300ml, filters, obtains filtrate a, standby；
Step 3: residue medicinal residues are added clear water again, to clear water dipped medical material upper surface 2-3cm, soaks 3-10 hour；
Step 4: be placed on fire by purple casserole, after intense fire boils, uses slow fire instead and decocts the 25-35 minute dosage to medicinal liquid slowly and be 100-300ml, filters, obtains filtrate b, mixed by filtrate a and filtrate b.
CN201610520346.3A 2016-07-04 2016-07-04 A kind of Chinese medicine treating acute type A viral hepatitis and preparation method thereof Pending CN106074927A (en)

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102836388A (en) * 2012-08-25 2012-12-26 李新欣 Traditional Chinese medicine for chronic hepatitis treatment
CN104042730A (en) * 2014-06-30 2014-09-17 曹健 Traditional Chinese medicine preparation for treating chronic hepatitis
CN105031421A (en) * 2015-08-16 2015-11-11 李英明 Traditional Chinese medicine for treating chronic hepatitis
CN105456565A (en) * 2016-01-03 2016-04-06 任兴斌 Traditional Chinese medicine preparation for treating hepatitis A and preparation method thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102836388A (en) * 2012-08-25 2012-12-26 李新欣 Traditional Chinese medicine for chronic hepatitis treatment
CN104042730A (en) * 2014-06-30 2014-09-17 曹健 Traditional Chinese medicine preparation for treating chronic hepatitis
CN105031421A (en) * 2015-08-16 2015-11-11 李英明 Traditional Chinese medicine for treating chronic hepatitis
CN105456565A (en) * 2016-01-03 2016-04-06 任兴斌 Traditional Chinese medicine preparation for treating hepatitis A and preparation method thereof

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Application publication date: 20161109