CN104491312A - Use of tradtional Chinese medicine preparation in preparing medicines for treating prostatitis and prostatauxe - Google Patents
Use of tradtional Chinese medicine preparation in preparing medicines for treating prostatitis and prostatauxe Download PDFInfo
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Abstract
The invention discloses a use of a tradtional Chinese medicine preparation in preparing medicines for treating prostatitis and prostatauxe. The tradtional Chinese medicine preparation is obtained by processing the following traditional Chinese herbal medicines through a modern pharmacy technique: semen platycladi, radix bupleuri, radix morindae officinalis, radix et rhizoma rhei, concha ostreae, cortex moutan radicis, radix salviae miltiorrhizae, poria, rhizoma dioscoreae, rhizoma alismatis, radix paeoniae rubra, semen phaseoli, spica prunellae, semen persicae, sargassum and radix scrophulariae. The traditional Chinese medicine preparation has the advantages of being fast to take effect, and good in effect, treating both symptoms and root causes, combining nursing with treating on the aspects of treating prostatitis and prostatauxe and also the preparation is low in process cost, stable in efficacy, and easy for popularization and application.
Description
Technical field
The present invention discloses the purposes of a kind of Chinese medicine preparation in preparation treatment prostatitis, prostate hyperplasia medicine, belongs to tcm field.
Background technology
Prostatitis is the commonly encountered diseases of Urology Surgery, in Urology Surgery male patient the right side of fifty, account for first place.Nineteen ninety-five NIH has formulated a kind of new prostatitis sorting technique, I type: be equivalent to the acute bacterial prostatitis in conventional sorting methods, II type: be equivalent to the chronic bacterial prostatitis in conventional sorting methods, III type: chronic prostatitis/chronic Pelvic Pain Syndrome, IV type: silent prostatitis.Wherein nonbacterial prostatitis is common far beyond bacterial prostatitis.
Prostate hyperplasia and prostatic hyperplasia.Prostatic hyperplasia (BPH) is one of male senile patient common disease, cumulative many with population in the world senescence onset of illness.The sickness rate of prostatic hyperplasia increased progressively with the age, but not necessarily had clinical symptoms when having preneoplastic lesions.Patients with Prostatic Hyperplasia is owing to being often associated with other chronic diseases for gerontal patient.
At present, at Modern Medical Field, the treatment of prostatic hyperplasia adopts the method for chemicals and operation more, and therapeutic effect is poor, and wound is large, particularly the misery that causes to patient of operative treatment and harm all very large.At China's Traditional Chinese Medicine, prostatic hyperplasia is early recognized.Prostatic hyperplasia belongs to the traditional Chinese medical science " difficulty in urination " category.This disease is mainly in old people, and young people also has generation.Card is shown in urinary obstruction or unfavorable.If companion sees brains and to swoon swollen, thirsty, rapid breathing, vexed, lower abdominal distention pain, red tongue with yellow fur, wiry and frequent pulse, mostly be three burnt fire and contain; Dry pharynx excessive thirst, rapid breathing, yellow fur, rapid pulse person, many genus lung-heat gas emperors.Excess syndrome is controlled should clearing away damp-heat, and dissipating blood stasis is tied, promoting the circulation of QI machine and tonneau water channel; Deficiency syndrome control suitable spleen reinforcing kidney, help gasification, make to gasify capable, and urine is from logical.Meanwhile, also will according to etiology and pathogenesis, pathological changes in the difference of spleen at kidney, carries out determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs at lung, can not abuse the crystalline substance of tonneau urine.In addition, still can, according to the theory of " it is certainly logical that upper orifices opens then lower orifices ", by dispersing and elevation lung qi method, open with catharsis, i.e. the method treatment of so-called " carry kettle and take off lid ".
The prostatitis traditional Chinese medical science belongs to " essence turbid " category, on the whole its pathological factor be the smart room of damp and hot stagnation of blood stasis, and prolonged illness is " kidney qi virtual loss, the middle deficiency of vital energy are weak " then, and in the differentiation of pathological process, accompany stagnation of liver-QI, emotional factors plays important effect in pathogenic process more.So all can erection disturbance be there is in later stage chronic prostatitis.Otherwise some idiopathic sexual dysfunctions, constrain, drainage difficulty for a long time, become again the paathogenic factor causing chronic prostatitis.Therefore emphasize while Drug therapy, need psychological counseling be paid attention to, just can bring out the best in each other.Drug therapy should be noted shaking soothing the liver and the kidney invigorating and essence nourishing, clearing away heat-damp and promoting diuresis fit applications of withering.
Summary of the invention
The technical problem to be solved in the present invention provides the purposes of a kind of Chinese medicine preparation in preparation treatment prostatitis, prostate hyperplasia medicine, develop a kind of Chinese medicine preparation for the treatment of prostatitis, prostate hyperplasia, and this Chinese medicine is wanted modern pharmaceutical technology can be utilized to make facilitate easy-to-use finished product preparation.
For solving the problems of the technologies described above, inventor is from self tcm clinical practice experience for many years, according to drug matching rule, in conjunction with the feature of modern pharmaceutical technology, again compatibility medical material, and repeatedly verified by clinical practice and adjust, final invention one has the Chinese prescription of remarkable therapeutic effect to prostatitis, prostate hyperplasia, and this Chinese prescription is (with parts by weight):
Semen Platycladi 8-22 part, Radix Bupleuri 7-19 part, Radix Morindae Officinalis 6-18 part, Radix Et Rhizoma Rhei 5-17 part, Concha Ostreae 14-33 part, Cortex Moutan 8-22 part, Radix Salviae Miltiorrhizae 6-18 part, Poria 10-24 part, Rhizoma Dioscoreae 8-20 part, Rhizoma Alismatis 9-23 part, Radix Paeoniae Rubra 7-21 part, Semen Phaseoli 7-19 part, Spica Prunellae 6-20 part, Semen Persicae 9-23 part, Sargassum 5-19 part, Radix Scrophulariae 5-15 part.
3 the prescription proportionings with optimum therapeuticing effect filtered out from clinical practice are:
Proportioning 1: Semen Platycladi 15 parts, Radix Bupleuri 13 parts, Radix Morindae Officinalis 12 parts, Radix Et Rhizoma Rhei 11 parts, Concha Ostreae 25 parts, Cortex Moutan 15 parts, Radix Salviae Miltiorrhizae 12 parts, 17 parts, Poria, Rhizoma Dioscoreae 14 parts, Rhizoma Alismatis 16 parts, Radix Paeoniae Rubra 14 parts, Semen Phaseoli 13 parts, Spica Prunellae 13 parts, 16 parts, Semen Persicae, Sargassum 12 parts, Radix Scrophulariae 10 parts.
Proportioning 2: Semen Platycladi 17 parts, Radix Bupleuri 14 parts, Radix Morindae Officinalis 13 parts, Radix Et Rhizoma Rhei 10 parts, Concha Ostreae 27 parts, Cortex Moutan 14 parts, Radix Salviae Miltiorrhizae 11 parts, 15 parts, Poria, Rhizoma Dioscoreae 13 parts, Rhizoma Alismatis 15 parts, Radix Paeoniae Rubra 15 parts, Semen Phaseoli 15 parts, Spica Prunellae 11 parts, 17 parts, Semen Persicae, Sargassum 13 parts, Radix Scrophulariae 11 parts.
Proportioning 3: Semen Platycladi 16 parts, Radix Bupleuri 15 parts, Radix Morindae Officinalis 15 parts, Radix Et Rhizoma Rhei 12 parts, Concha Ostreae 26 parts, Cortex Moutan 16 parts, Radix Salviae Miltiorrhizae 11 parts, 18 parts, Poria, Rhizoma Dioscoreae 13 parts, Rhizoma Alismatis 15 parts, Radix Paeoniae Rubra 13 parts, Semen Phaseoli 14 parts, Spica Prunellae 14 parts, 14 parts, Semen Persicae, Sargassum 13 parts, Radix Scrophulariae 11 parts.
The preparation technology of Chinese medicine preparation of the present invention is following steps:
(1), in prescription ratio each taste Chinese crude drug is accurately taken, for subsequent use;
(2), Semen Platycladi, Radix Morindae Officinalis, Radix Et Rhizoma Rhei, Concha Ostreae, Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, Semen Persicae are ground respectively, cross 40 mesh sieves, with the petroleum ether of the 2-6 of 65-85 DEG C times weight, at 75-85 DEG C of backflow defat 2-4h, medicinal residues are with the alcohol reflux 3 times of 85-90%, it is the thick paste of 1.25-1.30 that extracting solution is condensed into relative density at 65-70 DEG C, for subsequent use;
(3), Radix Bupleuri, Cortex Moutan, Poria, Rhizoma Dioscoreae, Rhizoma Alismatis, Semen Phaseoli, Spica Prunellae, Sargassum, Radix Scrophulariae are pulverized respectively, mixing, add the purified water of medical material 7-11 times weight, be 320-380W at power, temperature is microwave extraction 3 times under 65 DEG C of conditions, and each 20-50 minute filters, 3 filtrate mixing, it is the concentrated solution of 1.10-1.15 that concentrated filtrate obtains relative density at 50-65 DEG C;
(4), by concentrated solution adding isopyknic ethanol makes it precipitate, and fully stirs, centrifugal, get supernatant distilling under reduced pressure removing ethanol, and to be condensed into relative density at 65-70 DEG C be the thick paste of 1.25-1.30, merges with the thick paste of (2) step gained, add the dextrin of 0.3-0.6 times of total thick paste weight, stir, drying under reduced pressure under 65-75 DEG C of condition, obtains dry extract, pulverize, cross 80 mesh sieves, be raw material of Chinese medicine powder, for subsequent use;
(5), by raw material of Chinese medicine powder add adjuvant and make the dosage forms such as tablet, powder, pill, granule, capsule, be finished product.
The source that Chinese medicine preparation of the present invention is raw materials used and character feature:
Semen Platycladi: this product is the kernel of Cupressaceae plant Cacumen Platycladi.Sweet, flat.GUIXIN, kidney, large intestine channel.Tranquilizing by nourishing the heart, loosening bowel to relieve constipation.For restlessness of asrhenia type and insomnia, severe palpitation, dryness of the intestine makes secret.
Radix Bupleuri: this product is the dry root of umbelliferae bupleurum or Radix Bupeuri Scorzonerfolii..Bitter in the mouth, cold nature; Return liver, gallbladder meridian; Reconciling superficies and interior, soothing the liver, yang invigorating.
Radix Morindae Officinalis: this product is the dry root of dicotyledon Rubiaceae Radix Morindae Officinalis.Acrid in the mouth, sweet; Slightly warm in nature.Return kidney, Liver Channel; Reinforcing the kidney and supporting YANG, expelling wind and removing dampness, strengthening the tendons and bones.
Radix Et Rhizoma Rhei: this product is the dry root and rhizome of polygonum rheum palmatum, Rheum tanguticum or Rheum officinale.Bitter in the mouth, cold in nature; Return spleen, stomach, large intestine, liver, pericardium channel; Purging heat and dredging bowels, removing pathogenic heat from blood and toxic substance from the body, eliminating blood stasis and inducing menstruation.
Concha Ostreae: this product is the shell of the long Concha Ostreae of Ostreidae animal, Dalian Bay Concha Ostreae or Crassostrea rivularis.Salty in the mouth, cold nature; Return liver, gallbladder, kidney channel; Tranquillization with heavy prescription, YANG hyperactivity suppressing nourishing YIN, hard masses softening and resolving.
Cortex Moutan: this product is the dry root bark of ranunculaceae peony.Bitter in the mouth, pungent, cold nature; GUIXIN, liver, kidney channel; Clearing away heat and cooling blood, blood circulation promoting and blood stasis dispelling.
Radix Salviae Miltiorrhizae: this product is the dry root and rhizome of labiate Radix Salviae Miltiorrhizae.Bitter in the mouth, cold nature; GUIXIN, Liver Channel; Stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, clear away heart-fire relieving restlessness.
Poria: this product is the dry sclerotia of On Polyporaceae Poria.Sweet in the mouth, light, property is put down; GUIXIN, spleen, kidney channel; Eliminating dampness and diuresis, invigorating the spleen and regulating the stomach, mind tranquilizing and the heart calming.
Rhizoma Dioscoreae: this product is the dry rhizome of Dioscoreaceae plant Rhizoma Dioscoreae.Sweet in the mouth, property is put down; Return spleen, lung, kidney channel; Spleen reinforcing nourishing the stomach, promote the production of body fluid lung benefiting, the kidney invigorating arresting seminal emission.
Rhizoma Alismatis: this product is the dry tuber of Notes On Alism At Aceae Rhizoma Alismatis.Sweet in the mouth, cold in nature; Return kidney, urinary bladder channel; Diuresis, clearing away damp-heat.
Radix Paeoniae Rubra: this product is the dry root of ranunculaceae plant Radix Paeoniae or river Radix Paeoniae Rubra.Bitter in the mouth, cold nature; Return Liver Channel; Clearing away heat and cooling blood, eliminating stasis to stop pain.
Semen Phaseoli: this product is the seed of dicotyledon pulse family Semen Phaseoli or Semen Phaseoli.Sour in the mouth, sweet, property is put down; GUIXIN, small intestine meridian; Diuretic dehumidifies, and blood evacuation of pus, subduing swelling and detoxicating.Harness the river swollen, beriberi, jaundice, dysentery, has blood in stool, carbuncle.
Spica Prunellae: this product is the dry fruit ear of labiate Spica Prunellae.Acrid in the mouth, hardship, cold in nature; Return liver, gallbladder meridian; Relieve inflammation or internal heat, improving eyesight, eliminating stagnation, detumescence.
Semen Persicae: this product is the dry mature seed of rosaceous plant Fructus Persicae or Prunus davidiana.Bitter in the mouth, sweet, property is put down; GUIXIN, liver, large intestine channel; Blood circulation promoting and blood stasis dispelling, loosening bowel to relieve constipation.
Sargassum: this product is the dry frond of Sargassaceae plant Sargassum or Sargassum fusiforme (Harv.) Setch.Bitter in the mouth, salty, cold in nature; Return liver, stomach, kidney channel; Hard masses softening and resolving, expectorant, diuretic.
Radix Scrophulariae: this product is the dry root of goatweed Radix Scrophulariae.Sweet in the mouth, hardship, salty, cold nature; Return lung, stomach, kidney channel; Removing heat from blood YIN nourishing, eliminating fire and detoxication.
The prescription analysis of Chinese prescription of the present invention:
Chinese prescription of the present invention is with Concha Ostreae, Poria, Semen Persicae, Rhizoma Alismatis, Semen Platycladi for monarch drug, YANG hyperactivity suppressing nourishing YIN, hard masses softening and resolving, eliminating dampness and diuresis, loosening bowel to relieve constipation, clearing away heat and cooling blood; With Cortex Moutan, Radix Morindae Officinalis, Radix Paeoniae Rubra, Rhizoma Dioscoreae for ministerial drug, blood circulation promoting and blood stasis dispelling, eliminating blood stasis and inducing menstruation, the kidney invigorating arresting seminal emission; With Semen Phaseoli, Spica Prunellae, Sargassum, Radix Et Rhizoma Rhei for adjuvant drug, expectorant diuretic, mass dissipating and swelling eliminating, removing pathogenic heat from blood and toxic substance from the body; With Radix Bupleuri, Radix Salviae Miltiorrhizae, Radix Scrophulariae for making medicine, reconciling superficies and interior, promoting blood circulation to restore menstrual flow, removing heat from blood YIN nourishing; The all medicines of monarch coordinate, and complement each other, synergism, jointly reaches the effects such as YANG hyperactivity suppressing nourishing YIN, hard masses softening and resolving, the kidney invigorating arresting seminal emission, expectorant diuretic, removing heat from blood YIN nourishing, thus have therapeutic effect significantly to prostatitis, prostate hyperplasia.
With prior art ratio, Chinese medicine preparation of the present invention before the treatment row adenitis, prostate hyperplasia aspect has the treatment advantages such as instant effect, effective, treating both the principal and secondary aspects of a disease, medical treatment combination, and its preparation technology's cost is low, efficacy stability, be easy to apply.
The animal toxicity test of Chinese medicine preparation of the present invention
(1), acute toxicity test
1, test drug: by Chinese medicine granules obtained by prescription of the present invention and preparation technology, add purified water, be mixed with solution.Test animal used: regular grade NIH mice, body weight 20g ± 2g, male and female half and half, female mice is all without pregnant;
2, apply mice to carry out acute toxicity testing and show: mouse stomach By Chinese Medicines, under 744.5g crude drug/kg dosage, after administration, mice occurs that light activity reduces, 1.5 hours recover normal, Continuous Observation 7 days after administration, none dead mouse, and overall health of patients, diet, take the photograph water, urine and body weight increase all normal.Experimental result shows: the maximum dosage-feeding of mouse stomach By Chinese Medicines is 744.5g crude drug/kg/d(LD
50> 744.5g crude drug/kg).Chinese medicine preparation clinical application every day total amount of the present invention is 0.22g crude drug/kg/d; By weighing machine, the dosis tolerata of mouse stomach Chinese medicine preparation of the present invention is 3384.1 times of clinical patient.Point out this medicine acute toxicity extremely low, clinical drug safety.
(2), long-term toxicity test for animals
1, medicine: by Chinese medicine granules obtained by prescription of the present invention and preparation technology, add purified water, be mixed with solution.
2, animal: regular grade SD rat, original body mass 220 ± 8g, male and female half and half, female rats is all without pregnant.
3, method and result:
(1), By Chinese Medicines: mix high, medium and low three dosage groups, per weight dosage is respectively 180,60,20 times of patient's dose;
(2), by experimental mouse be divided into 4 groups at random, wherein the By Chinese Medicines of 3 groups of difference gavages, three dosage, remains one group of gavage normal saline (40 times of patient's dose); All 4 groups of all continuous gavages 180 days, observe animal general toxic reaction and the order of severity, check each position, and carry out hematology, the pathological examination of the main organs such as ALT, BUN and the heart, liver, spleen, lung, kidney, stomach after execution by rule of operation;
(3), through long-term feeding, all there is not toxic reaction in 4 groups of rats.Physically well develop.Macroscopic appearance and main organs no abnormality seen.Peripheral hemogram and Serum ALT, BUN compare with matched group and change without pathologic.The all not significant changes such as the pathological replacement heart, liver, spleen, lung, kidney, stomach, therefore, think through proved by pathology, Chinese medicine preparation of the present invention shows without chronic toxicity animal.
By above two toxicity tests, prove that Chinese medicine preparation of the present invention is safe, have no side effect, can be taken by patient.
The experimental study of the anti-prostatic hyperplasia of Chinese medicine granules of the present invention:
(1) test drug: by Chinese medicine granules obtained by prescription of the present invention and preparation technology, the crude drug content of granule is 0.33g crude drug/g granule, adds purified water, is mixed with solution.Test animal used: regular grade NIH mice, body weight 24g ± 2g, male; Regular grade SD rat, original body mass 220 ± 10g, male.
(2) test method and result: by SD rat castration subcutaneous injection testosterone 4mg/kg after 7 days, simultaneously give 0.55g/kg, 1.1g/kg, the Chinese medicine granules of the present invention (being equivalent to 2.5,5 of clinical plan consumption, 10 times) of 2.2g/kg, once a day, 7 days weekly, after continuous 5 weeks, detection is put to death.
Test shows, the prostate index of big or middle dosage group, prostate dry weight, notopodium weight comparatively model group have significant difference, and the prostate volume of heavy dose of group comparatively model group has extremely significant difference; The height of glandular epithelium of dosage group big or middle, lumen caliber comparatively model group have significant difference, the acid phosphatase of heavy dose of group, and the DNA content of big or middle dosage group comparatively model group has significant difference.Test prompting, Chinese medicine suppository of the present invention has more significant inhibitory action to benign prostatic hyperplasia under this experimental condition.
The antiinflammatory action of Chinese medicine granules of the present invention:
For the impact that abdominal cavity blood capillary permeability increases
Method: by mice by after body weight random packet, gavage gives various dose and (is equivalent to 1 of clinical plan consumption respectively, 2, 4 times) the solution of Chinese medicine granules of the present invention modulation, matched group gives the distilled water of same volume, after 1 hour, tail vein injection 0.5% Evans blue liquid 0.2ml/10g mice, within 10 minutes, pneumoretroperitoneum only injects 0.8% glacial acetic acid 0.2ml/, animal is put to death after 20 minutes, lumbar injection 5ml normal saline, soft abdominal part, cut off osculum, draw peritoneal fluid, centrifuging and taking supernatant, densitometric value under wavelength 590nm, statistical procedures (see table 1) is carried out with t inspection.
Impact (n=10) that table 1 Chinese medicinal granule of the present invention increases mouse peritoneal capillary permeability (
± SD)
Note: * P < 0.05, * * P < 0.01 compared with matched group.
Result is from table 1 result, and Chinese medicine preparation of the present invention can obviously suppress acetic acid to stimulate increasing of the mouse peritoneal capillary permeability caused.
The clinical trial of Chinese medicine granules of the present invention:
(1), this test patient provides by certain the People's Hospital of city, be provided with 120 make a definite diagnosis suffer from prostatitis, the patient of prostate hyperplasia participates in, age 32-65 year.
(2), test medication: the granule produced by prescription optimum ratio 1 of the present invention and preparation technology of the present invention, the crude drug content of granule is 0.33g crude drug/g granule.
(3), test method: patient's oral granule, every day 2 times, each 20g 3 weeks is a course for the treatment of, treats 4 courses for the treatment of continuously.
(4), judgment criteria
Cure: prostatitis, prostate hyperplasia related symptoms disappear completely, and make a definite diagnosis through doctor and fully recover;
Effective: prostatitis, prostate hyperplasia related symptoms partial disappearance, still need further treatment;
Invalid: prostatitis, prostate hyperplasia related symptoms are without any improvement, even more serious.
(5), therapeutic outcome
120 patients have 115 patients to complete experiment, have 5 routine patients to come off; Wherein 57 example recoveries from illness, 53 examples are effective, and 5 examples are invalid, and cure rate is 49.6%, and total effective rate is 95.6%.
(6), conclusion
Clinical test results shows, and Chinese medicine preparation of the present invention before the treatment row adenitis, prostate hyperplasia aspect has very significant therapeutic effect, and therefore, Chinese medicine preparation of the present invention has significant technical advantage, achieves beat all technological achievement.
Detailed description of the invention
Embodiment 1
Produce by Chinese prescription medical material ratio range minima of the present invention:
(1) Semen Platycladi 800g, Radix Bupleuri 700g, Radix Morindae Officinalis 600g, Radix Et Rhizoma Rhei 500g, Concha Ostreae 1400g, Cortex Moutan 800g, Radix Salviae Miltiorrhizae 600g, Poria 1000g, Rhizoma Dioscoreae 800g, Rhizoma Alismatis 900g, Radix Paeoniae Rubra 700g, Semen Phaseoli 700g, Spica Prunellae 600g, Semen Persicae 900g, Sargassum 500g, Radix Scrophulariae 500g, in prescription ratio is accurately taken, for subsequent use;
(2), Semen Platycladi, Radix Morindae Officinalis, Radix Et Rhizoma Rhei, Concha Ostreae, Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, Semen Persicae are ground respectively, cross 40 mesh sieves, with the petroleum ether of 4 times of weight of 75 DEG C, at 80 DEG C of backflow defat 3h, medicinal residues with 86% alcohol reflux 3 times, it is the thick paste of 1.25-1.30 that extracting solution is condensed into relative density at 65-70 DEG C, for subsequent use;
(3), Radix Bupleuri, Cortex Moutan, Poria, Rhizoma Dioscoreae, Rhizoma Alismatis, Semen Phaseoli, Spica Prunellae, Sargassum, Radix Scrophulariae are pulverized respectively, mixing, add the purified water of medical material 9 times of weight, be 320-380W at power, temperature is microwave extraction 3 times under 65 DEG C of conditions, each 40 minutes, filters, 3 filtrate mixing, it is the concentrated solution of 1.10-1.15 that concentrated filtrate obtains relative density at 50-65 DEG C;
(4), by concentrated solution adding isopyknic ethanol makes it precipitate, and fully stirs, centrifugal, get supernatant distilling under reduced pressure removing ethanol, and to be condensed into relative density at 65-70 DEG C be the thick paste of 1.25-1.30, merges with the thick paste of (2) step gained, add the dextrin of 0.5 times of total thick paste weight, stir, drying under reduced pressure under 70 DEG C of conditions, obtains dry extract, pulverize, cross 80 mesh sieves, be raw material of Chinese medicine powder, for subsequent use;
(5), by raw material of Chinese medicine powder add adjuvant and make granule, be finished product.
The crude drug content of granule is 0.33g crude drug/g granule, and clinical taking dose is every day 2 times, and each 20g 3 weeks is a course for the treatment of.
Embodiment 2
Produce by Chinese prescription medical material ratio range maximum of the present invention:
(1) Semen Platycladi 2200g, Radix Bupleuri 1900g, Radix Morindae Officinalis 1800g, Radix Et Rhizoma Rhei 1700g, Concha Ostreae 3300g, Cortex Moutan 2200g, Radix Salviae Miltiorrhizae 1800g, Poria 2400g, Rhizoma Dioscoreae 2000g, Rhizoma Alismatis 2300g, Radix Paeoniae Rubra 2100g, Semen Phaseoli 1900g, Spica Prunellae 2000g, Semen Persicae 2300g, Sargassum 1900g, Radix Scrophulariae 1500g, in prescription ratio is accurately taken, for subsequent use;
(2), Semen Platycladi, Radix Morindae Officinalis, Radix Et Rhizoma Rhei, Concha Ostreae, Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, Semen Persicae are ground respectively, cross 40 mesh sieves, with the petroleum ether of 4 times of weight of 75 DEG C, at 80 DEG C of backflow defat 3h, medicinal residues with 86% alcohol reflux 3 times, it is the thick paste of 1.25-1.30 that extracting solution is condensed into relative density at 65-70 DEG C, for subsequent use;
(3), Radix Bupleuri, Cortex Moutan, Poria, Rhizoma Dioscoreae, Rhizoma Alismatis, Semen Phaseoli, Spica Prunellae, Sargassum, Radix Scrophulariae are pulverized respectively, mixing, add the purified water of medical material 9 times of weight, be 320-380W at power, temperature is microwave extraction 3 times under 65 DEG C of conditions, each 40 minutes, filters, 3 filtrate mixing, it is the concentrated solution of 1.10-1.15 that concentrated filtrate obtains relative density at 50-65 DEG C;
(4), by concentrated solution adding isopyknic ethanol makes it precipitate, and fully stirs, centrifugal, get supernatant distilling under reduced pressure removing ethanol, and to be condensed into relative density at 65-70 DEG C be the thick paste of 1.25-1.30, merges with the thick paste of (2) step gained, add the dextrin of 0.5 times of total thick paste weight, stir, drying under reduced pressure under 70 DEG C of conditions, obtains dry extract, pulverize, cross 80 mesh sieves, be raw material of Chinese medicine powder, for subsequent use;
(5), by raw material of Chinese medicine powder add adjuvant and make granule, be finished product.
The crude drug content of granule is 0.33g crude drug/g granule, and clinical taking dose is every day 2 times, and each 20g 3 weeks is a course for the treatment of.
Embodiment 3
Produce by arbitrary value in Chinese prescription medical material ratio range of the present invention:
(1) Semen Platycladi 900g, Radix Bupleuri 1800g, Radix Morindae Officinalis 700g, Radix Et Rhizoma Rhei 1600g, Concha Ostreae 1500g, Cortex Moutan 2100g, Radix Salviae Miltiorrhizae 700g, Poria 2300g, Rhizoma Dioscoreae 900g, Rhizoma Alismatis 2200g, Radix Paeoniae Rubra 800g, Semen Phaseoli 1800g, Spica Prunellae 700g, Semen Persicae 2200g, Sargassum 600g, Radix Scrophulariae 1400g, in prescription ratio is accurately taken, for subsequent use;
(2), Semen Platycladi, Radix Morindae Officinalis, Radix Et Rhizoma Rhei, Concha Ostreae, Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, Semen Persicae are ground respectively, cross 40 mesh sieves, with the petroleum ether of 4 times of weight of 75 DEG C, at 80 DEG C of backflow defat 3h, medicinal residues with 86% alcohol reflux 3 times, it is the thick paste of 1.25-1.30 that extracting solution is condensed into relative density at 65-70 DEG C, for subsequent use;
(3), Radix Bupleuri, Cortex Moutan, Poria, Rhizoma Dioscoreae, Rhizoma Alismatis, Semen Phaseoli, Spica Prunellae, Sargassum, Radix Scrophulariae are pulverized respectively, mixing, add the purified water of medical material 9 times of weight, be 320-380W at power, temperature is microwave extraction 3 times under 65 DEG C of conditions, each 40 minutes, filters, 3 filtrate mixing, it is the concentrated solution of 1.10-1.15 that concentrated filtrate obtains relative density at 50-65 DEG C;
(4), by concentrated solution adding isopyknic ethanol makes it precipitate, and fully stirs, centrifugal, get supernatant distilling under reduced pressure removing ethanol, and to be condensed into relative density at 65-70 DEG C be the thick paste of 1.25-1.30, merges with the thick paste of (2) step gained, add the dextrin of 0.5 times of total thick paste weight, stir, drying under reduced pressure under 70 DEG C of conditions, obtains dry extract, pulverize, cross 80 mesh sieves, be raw material of Chinese medicine powder, for subsequent use;
(5), by raw material of Chinese medicine powder add adjuvant and make granule, be finished product.
The crude drug content of granule is 0.33g crude drug/g granule, and clinical taking dose is every day 2 times, and each 20g 3 weeks is a course for the treatment of.
Embodiment 4
Produce by the value of Chinese prescription optimum ratio 1 of the present invention:
(1) Semen Platycladi 1500g, Radix Bupleuri 1300g, Radix Morindae Officinalis 1200g, Radix Et Rhizoma Rhei 1100g, Concha Ostreae 2500g, Cortex Moutan 1500g, Radix Salviae Miltiorrhizae 1200g, Poria 1700g, Rhizoma Dioscoreae 1400g, Rhizoma Alismatis 1600g, Radix Paeoniae Rubra 1400g, Semen Phaseoli 1300g, Spica Prunellae 1300g, Semen Persicae 1600g, Sargassum 1200g, Radix Scrophulariae 1000g, in prescription ratio is accurately taken, for subsequent use;
(2), Semen Platycladi, Radix Morindae Officinalis, Radix Et Rhizoma Rhei, Concha Ostreae, Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, Semen Persicae are ground respectively, cross 40 mesh sieves, with the petroleum ether of 4 times of weight of 75 DEG C, at 80 DEG C of backflow defat 3h, medicinal residues with 86% alcohol reflux 3 times, it is the thick paste of 1.25-1.30 that extracting solution is condensed into relative density at 65-70 DEG C, for subsequent use;
(3), Radix Bupleuri, Cortex Moutan, Poria, Rhizoma Dioscoreae, Rhizoma Alismatis, Semen Phaseoli, Spica Prunellae, Sargassum, Radix Scrophulariae are pulverized respectively, mixing, add the purified water of medical material 9 times of weight, be 320-380W at power, temperature is microwave extraction 3 times under 65 DEG C of conditions, each 40 minutes, filters, 3 filtrate mixing, it is the concentrated solution of 1.10-1.15 that concentrated filtrate obtains relative density at 50-65 DEG C;
(4), by concentrated solution adding isopyknic ethanol makes it precipitate, and fully stirs, centrifugal, get supernatant distilling under reduced pressure removing ethanol, and to be condensed into relative density at 65-70 DEG C be the thick paste of 1.25-1.30, merges with the thick paste of (2) step gained, add the dextrin of 0.5 times of total thick paste weight, stir, drying under reduced pressure under 70 DEG C of conditions, obtains dry extract, pulverize, cross 80 mesh sieves, be raw material of Chinese medicine powder, for subsequent use;
(5), by raw material of Chinese medicine powder add adjuvant and make granule, be finished product.
The crude drug content of granule is 0.33g crude drug/g granule, and clinical taking dose is every day 2 times, and each 20g 3 weeks is a course for the treatment of.
Embodiment 5
Produce by the value of Chinese prescription optimum ratio 2 of the present invention:
(1) Semen Platycladi 1700g, Radix Bupleuri 1400g, Radix Morindae Officinalis 1300g, Radix Et Rhizoma Rhei 1000g, Concha Ostreae 2700g, Cortex Moutan 1400g, Radix Salviae Miltiorrhizae 1100g, Poria 1500g, Rhizoma Dioscoreae 1300g, Rhizoma Alismatis 1500g, Radix Paeoniae Rubra 1500g, Semen Phaseoli 1500g, Spica Prunellae 1100g, Semen Persicae 1700g, Sargassum 1300g, Radix Scrophulariae 1100g, in prescription ratio is accurately taken, for subsequent use;
(2), Semen Platycladi, Radix Morindae Officinalis, Radix Et Rhizoma Rhei, Concha Ostreae, Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, Semen Persicae are ground respectively, cross 40 mesh sieves, with the petroleum ether of 4 times of weight of 75 DEG C, at 80 DEG C of backflow defat 3h, medicinal residues with 86% alcohol reflux 3 times, it is the thick paste of 1.25-1.30 that extracting solution is condensed into relative density at 65-70 DEG C, for subsequent use;
(3), Radix Bupleuri, Cortex Moutan, Poria, Rhizoma Dioscoreae, Rhizoma Alismatis, Semen Phaseoli, Spica Prunellae, Sargassum, Radix Scrophulariae are pulverized respectively, mixing, add the purified water of medical material 9 times of weight, be 320-380W at power, temperature is microwave extraction 3 times under 65 DEG C of conditions, each 40 minutes, filters, 3 filtrate mixing, it is the concentrated solution of 1.10-1.15 that concentrated filtrate obtains relative density at 50-65 DEG C;
(4), by concentrated solution adding isopyknic ethanol makes it precipitate, and fully stirs, centrifugal, get supernatant distilling under reduced pressure removing ethanol, and to be condensed into relative density at 65-70 DEG C be the thick paste of 1.25-1.30, merges with the thick paste of (2) step gained, add the dextrin of 0.5 times of total thick paste weight, stir, drying under reduced pressure under 70 DEG C of conditions, obtains dry extract, pulverize, cross 80 mesh sieves, be raw material of Chinese medicine powder, for subsequent use;
(5), by raw material of Chinese medicine powder add adjuvant and make granule, be finished product.
The crude drug content of granule is 0.33g crude drug/g granule, and clinical taking dose is every day 2 times, and each 20g 3 weeks is a course for the treatment of.
Embodiment 6
Produce by the value of Chinese prescription optimum ratio 3 of the present invention:
(1) Semen Platycladi 1600g, Radix Bupleuri 1500g, Radix Morindae Officinalis 1500g, Radix Et Rhizoma Rhei 1200g, Concha Ostreae 2600g, Cortex Moutan 1600g, Radix Salviae Miltiorrhizae 1100g, Poria 1800g, Rhizoma Dioscoreae 1300g, Rhizoma Alismatis 1500g, Radix Paeoniae Rubra 1300g, Semen Phaseoli 1400g, Spica Prunellae 1400g, Semen Persicae 1400g, Sargassum 1300g, Radix Scrophulariae 1100g, in prescription ratio is accurately taken, for subsequent use;
(2), Semen Platycladi, Radix Morindae Officinalis, Radix Et Rhizoma Rhei, Concha Ostreae, Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, Semen Persicae are ground respectively, cross 40 mesh sieves, with the petroleum ether of 4 times of weight of 75 DEG C, at 80 DEG C of backflow defat 3h, medicinal residues with 86% alcohol reflux 3 times, it is the thick paste of 1.25-1.30 that extracting solution is condensed into relative density at 65-70 DEG C, for subsequent use;
(3), Radix Bupleuri, Cortex Moutan, Poria, Rhizoma Dioscoreae, Rhizoma Alismatis, Semen Phaseoli, Spica Prunellae, Sargassum, Radix Scrophulariae are pulverized respectively, mixing, add the purified water of medical material 9 times of weight, be 320-380W at power, temperature is microwave extraction 3 times under 65 DEG C of conditions, each 40 minutes, filters, 3 filtrate mixing, it is the concentrated solution of 1.10-1.15 that concentrated filtrate obtains relative density at 50-65 DEG C;
(4), by concentrated solution adding isopyknic ethanol makes it precipitate, and fully stirs, centrifugal, get supernatant distilling under reduced pressure removing ethanol, and to be condensed into relative density at 65-70 DEG C be the thick paste of 1.25-1.30, merges with the thick paste of (2) step gained, add the dextrin of 0.5 times of total thick paste weight, stir, drying under reduced pressure under 70 DEG C of conditions, obtains dry extract, pulverize, cross 80 mesh sieves, be raw material of Chinese medicine powder, for subsequent use;
(5), by raw material of Chinese medicine powder add adjuvant and make granule, be finished product.
The crude drug content of granule is 0.33g crude drug/g granule, and clinical taking dose is every day 2 times, and each 20g 3 weeks is a course for the treatment of.
Claims (6)
1. the purposes of Chinese medicine preparation in preparation treatment prostatitis, prostate hyperplasia medicine, it is characterized in that, described Chinese medicine preparation comprises the Chinese medicine of following weight portion:
Semen Platycladi 8-22 part, Radix Bupleuri 7-19 part, Radix Morindae Officinalis 6-18 part, Radix Et Rhizoma Rhei 5-17 part, Concha Ostreae 14-33 part, Cortex Moutan 8-22 part, Radix Salviae Miltiorrhizae 6-18 part, Poria 10-24 part, Rhizoma Dioscoreae 8-20 part, Rhizoma Alismatis 9-23 part, Radix Paeoniae Rubra 7-21 part, Semen Phaseoli 7-19 part, Spica Prunellae 6-20 part, Semen Persicae 9-23 part, Sargassum 5-19 part, Radix Scrophulariae 5-15 part.
2. purposes according to claim 1, is characterized in that, described Chinese medicine preparation comprises the Chinese medicine of following weight portion:
Semen Platycladi 15 parts, Radix Bupleuri 13 parts, Radix Morindae Officinalis 12 parts, Radix Et Rhizoma Rhei 11 parts, Concha Ostreae 25 parts, Cortex Moutan 15 parts, Radix Salviae Miltiorrhizae 12 parts, 17 parts, Poria, Rhizoma Dioscoreae 14 parts, Rhizoma Alismatis 16 parts, Radix Paeoniae Rubra 14 parts, Semen Phaseoli 13 parts, Spica Prunellae 13 parts, 16 parts, Semen Persicae, Sargassum 12 parts, Radix Scrophulariae 10 parts.
3. purposes according to claim 1, is characterized in that, described Chinese medicine preparation comprises the Chinese medicine of following weight portion:
Semen Platycladi 17 parts, Radix Bupleuri 14 parts, Radix Morindae Officinalis 13 parts, Radix Et Rhizoma Rhei 10 parts, Concha Ostreae 27 parts, Cortex Moutan 14 parts, Radix Salviae Miltiorrhizae 11 parts, 15 parts, Poria, Rhizoma Dioscoreae 13 parts, Rhizoma Alismatis 15 parts, Radix Paeoniae Rubra 15 parts, Semen Phaseoli 15 parts, Spica Prunellae 11 parts, 17 parts, Semen Persicae, Sargassum 13 parts, Radix Scrophulariae 11 parts.
4. purposes according to claim 1, is characterized in that, described Chinese medicine preparation comprises the Chinese medicine of following weight portion:
Semen Platycladi 16 parts, Radix Bupleuri 15 parts, Radix Morindae Officinalis 15 parts, Radix Et Rhizoma Rhei 12 parts, Concha Ostreae 26 parts, Cortex Moutan 16 parts, Radix Salviae Miltiorrhizae 11 parts, 18 parts, Poria, Rhizoma Dioscoreae 13 parts, Rhizoma Alismatis 15 parts, Radix Paeoniae Rubra 13 parts, Semen Phaseoli 14 parts, Spica Prunellae 14 parts, 14 parts, Semen Persicae, Sargassum 13 parts, Radix Scrophulariae 11 parts.
5., according to the arbitrary described purposes of claim 1-4, it is characterized in that, the preparation technology of described Chinese medicine preparation is following steps:
Step (1), accurately take each taste Chinese crude drug in prescription ratio, for subsequent use;
Step (2), Semen Platycladi, Radix Morindae Officinalis, Radix Et Rhizoma Rhei, Concha Ostreae, Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, Semen Persicae to be ground respectively, cross 40 mesh sieves, with the petroleum ether of the 2-6 of 65-85 DEG C times weight, at 75-85 DEG C of backflow defat 2-4h, medicinal residues are with the alcohol reflux 3 times of 85-90%, it is the thick paste of 1.25-1.30 that extracting solution is condensed into relative density at 65-70 DEG C, for subsequent use;
Step (3), Radix Bupleuri, Cortex Moutan, Poria, Rhizoma Dioscoreae, Rhizoma Alismatis, Semen Phaseoli, Spica Prunellae, Sargassum, Radix Scrophulariae to be pulverized respectively, mixing, add the purified water of medical material 7-11 times weight, be 320-380W at power, temperature is microwave extraction 3 times under 65 DEG C of conditions, and each 20-50 minute filters, 3 filtrate mixing, it is the concentrated solution of 1.10-1.15 that concentrated filtrate obtains relative density at 50-65 DEG C;
Step (4), concentrated solution is added isopyknic ethanol make it precipitate, fully stir, centrifugal, get supernatant distilling under reduced pressure removing ethanol, and to be condensed into relative density at 65-70 DEG C be the thick paste of 1.25-1.30, merges with the thick paste of (2) step gained, add the dextrin of 0.3-0.6 times of total thick paste weight, stir, drying under reduced pressure under 65-75 DEG C of condition, obtains dry extract, pulverize, cross 80 mesh sieves, be raw material of Chinese medicine powder, for subsequent use;
Step (5), by raw material of Chinese medicine powder add adjuvant make finished product.
6., according to the arbitrary described purposes of claim 1-4, it is characterized in that, described Chinese medicine preparation can make tablet, powder, pill, granule and capsule.
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| CN105641066A (en) * | 2016-04-12 | 2016-06-08 | 练燕媚 | Traditional Chinese medicine for treating prostatic hyperplasia |
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