CN105169265A - Traditional Chinese medicine composition for treating hemiplegia and preparation method of traditional Chinese medicine composition - Google Patents

Abstract

The invention relates to the field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for treating hemiplegia. The traditional Chinese medicine composition comprises ginseng, astragalus membranaceus, Chinese angelica, pseudo ginseng, little multibanded krait, stiff silkworms, leeches, centipedes, bezoar, ground beetles, safflower, pilose asiabell roots, white paeony roots, liquorice, platycodon roots, common threewingnut roots, prepared rehmannia roots, motherwort herb, fructus lycii, human placenta, Chinese yam, ganoderma lucidum, spina date seed and the like. Compared with the prior art, the traditional Chinese medicine composition has the advantages of good curative effect, low cost, small limitation, no adverse reaction and the like, performs the functions of adjustment for mechanism balance, elimination of thrombus, reduction of cholesterol, softening of blood vessels, regulation of viscera functions, adjustment of blood pressure, restoration of yin-yang balance of a human body and the like, reduces hyperlipidemia, hypertension and hyperglycemia, effectively treats hemiplegia symptoms and can be conveniently popularized and used on a large scale clinically.

Description

A kind of Chinese medicine composition for the treatment of hemiplegia and preparation method thereof

Technical field

The invention belongs to technical field of traditional Chinese pharmacology, be specifically related to a kind of Chinese medicine composition for the treatment of hemiplegia and preparation method thereof.

Background technology

The appearance of the diseases such as the overnutrition of the modern life and diabetes, arteriosclerosis, hypertension, thus define apoplectic hemiplegia range of conditions, it be suddenly faint, unconscious, with facial hemiparalysis, dysphonia, hemiplegia or occur suddenly the class disease that hemiplegia is cardinal symptom without fainting.No matter child, young or person in middle and old age all can be ill, this disease has the four high features of more than such as sickness rate is high, mortality rate is high, disability rate is high, relapse rate is high, complication is many.

Hemiplegia is hemiplegia again, and referring to the dyskinesia of side upper and lower extremities, facial muscle and lingualis bottom, is the common sympton of acute cerebrovascular disease.Although slight hemiplegic patient still can be movable, walk, often upper limb flexing, lower limb stretch, and the lower limb of paralysis make a move and draw half circle, and this special walking posture, is called hemiplegic gait.Severe patient is often unable to leave the bed, and loses viability.According to the degree of hemiplegia, paresis, paresis and panplegia can be divided into.Paresis: show as muscular strength and weaken, muscular strength, at 4 ~ 5 grades, does not generally affect daily life, and imperfection paralysis is paresis weight comparatively, and scope is comparatively large, muscular strength 2 ~ 4 grades, panplegia: muscular strength 0 ~ 1 grade, paralyzed limbs is completely stiff.

The existing medicine of disease treatment at present for hemiplegia does not reach obvious effect, and therapeutic process is long, and a lot of needs of patients is taken medicine all the life, and the state of an illness occurs again and again, even easily causes rupture of blood vessel in brain.Existing medicine is for oral administration, and major part has toxic and side effects, and price comparison is expensive, and therapeutic effect is not obvious, brings certain financial difficulties to the family of patient.

Summary of the invention

In order to overcome deficiency of the prior art, the invention provides a kind of Chinese medicine composition for the treatment of hemiplegia, to hemiplegia, there is significant curative effect.

In order to solve the problems of the technologies described above, the technical solution used in the present invention is as follows: a kind of Chinese medicine composition for the treatment of hemiplegia, is made up of following component:

Radix Ginseng, the Radix Astragali, Radix Angelicae Sinensis, Radix Notoginseng, Agkistrodon, Bombyx Batryticatus, Hirudo, Scolopendra, Calculus Bovis, Eupolyphaga Seu Steleophaga, Flos Carthami, Radix Codonopsis, the Radix Paeoniae Alba, Radix Glycyrrhizae, Radix Platycodonis, Radix Tripterygii Wilfordii, Radix Rehmanniae Preparata, Herba Leonuri, Fructus Lycii, Placenta Hominis, Rhizoma Dioscoreae, Ganoderma, Semen Ziziphi Spinosae, Endothelium Corneum Gigeriae Galli, Poria, Rhizoma Polygoni Cuspidati, Semen Euphorbiae, Spica Prunellae, Radix Bupleuri, Cordyceps, Rhizoma Chuanxiong, Fructus Corni, Rhizoma Curcumae Longae, Rhizoma Alismatis, Moschus, Rhizoma Gastrodiae, Pheretima.

As preferably, the present invention is made up of each component of following parts by weight:

Radix Ginseng 1-30 part, Radix Astragali 1-30 part, Radix Angelicae Sinensis 1-30 part, Radix Notoginseng 1-30 part, Agkistrodon 1-30 part, Bombyx Batryticatus 1-30 part, Hirudo 1-30 part, Scolopendra 1-30 part, Calculus Bovis 1-30 part, Eupolyphaga Seu Steleophaga 1-30 part, Flos Carthami 1-30 part, Radix Codonopsis 1-30 part, Radix Paeoniae Alba 1-30 part, Radix Glycyrrhizae 1-30 part, Radix Platycodonis 1-30 part, Radix Tripterygii Wilfordii 1-30 part, Radix Rehmanniae Preparata 1-30 part, Herba Leonuri 1-30 part, Fructus Lycii 1-30 part, Placenta Hominis 1-30 part, Rhizoma Dioscoreae 1-30 part, Ganoderma 1-30 part, Semen Ziziphi Spinosae 1-30 part, Endothelium Corneum Gigeriae Galli 1-30 part, Poria 1-30 part, Rhizoma Polygoni Cuspidati 1-30 part, Semen Euphorbiae 1-30 part, Radix Bupleuri 1-30 part, Cordyceps 0.5-30 part, Spica Prunellae 1-30 part, Rhizoma Chuanxiong 1-30 part, Fructus Corni 1-30 part, Rhizoma Curcumae Longae 1-30 part, Rhizoma Alismatis 1-30 part, Moschus 1-30 part, Rhizoma Gastrodiae 1-30 part, Pheretima 1-30 part.

As preferably, the present invention is made up of each component of following parts by weight:

Radix Ginseng 1-15 part, Radix Astragali 1-15 part, Radix Angelicae Sinensis 1-15 part, Radix Notoginseng 1-15 part, Agkistrodon 1-15 part, Bombyx Batryticatus 1-15 part, Hirudo 1-15 part, Scolopendra 1-15 part, Calculus Bovis 1-15 part, Eupolyphaga Seu Steleophaga 1-15 part, Flos Carthami 1-15 part, Radix Codonopsis 1-15 part, Radix Paeoniae Alba 1-15 part, Radix Glycyrrhizae 1-15 part, Radix Platycodonis 1-15 part, Radix Tripterygii Wilfordii 1-15 part, Radix Rehmanniae Preparata 1-15 part, Herba Leonuri 1-15 part, Fructus Lycii 1-15 part, Placenta Hominis 1-15 part, Rhizoma Dioscoreae 1-15 part, Ganoderma 1-15 part, Semen Ziziphi Spinosae 1-15 part, Endothelium Corneum Gigeriae Galli 1-15 part, Poria 1-15 part, Rhizoma Polygoni Cuspidati 1-15 part, Semen Euphorbiae 1-15 part, Spica Prunellae 1-15 part, Radix Bupleuri 1-15 part, Cordyceps 0.5-8 part, Rhizoma Chuanxiong 1-15 part, Fructus Corni 1-15 part, Rhizoma Curcumae Longae 1-15 part, Rhizoma Alismatis 1-15 part, Moschus 1-15 part, Rhizoma Gastrodiae 1-15 part, Pheretima 1-15 part.

As preferably, the present invention includes each component composition of following parts by weight: Radix Ginseng 1-10 part, Radix Astragali 1-10 part, Radix Angelicae Sinensis 1-10 part, Radix Notoginseng 1-10 part, Agkistrodon 1-10 part, Bombyx Batryticatus 1-10 part, Hirudo 1-10 part, Scolopendra 1-10 part, Calculus Bovis 1-10 part, Eupolyphaga Seu Steleophaga 1-10 part, Flos Carthami 1-10 part, Radix Codonopsis 1-10 part, Radix Paeoniae Alba 1-10 part, Radix Glycyrrhizae 1-10 part, Radix Platycodonis 1-10 part, Radix Tripterygii Wilfordii 1-10 part, Radix Rehmanniae Preparata 1-10 part, Herba Leonuri 1-10 part, Fructus Lycii 1-10 part, Placenta Hominis 1-10 part, Rhizoma Dioscoreae 1-10 part, Ganoderma 1-10 part, Semen Ziziphi Spinosae 1-10 part, Endothelium Corneum Gigeriae Galli 1-10 part, Poria 1-10 part, Rhizoma Polygoni Cuspidati 1-10 part, Semen Euphorbiae 1-10 part, Spica Prunellae 1-10 part, Radix Bupleuri 1-10 part, Cordyceps 0.5-8 part, Rhizoma Chuanxiong 1-10 part, Fructus Corni 1-10 part, Rhizoma Curcumae Longae 1-10 part, Rhizoma Alismatis 1-10 part, Moschus 1-10 part, Rhizoma Gastrodiae 1-10 part, Pheretima 1-10 part.

As preferably, the dosage form of Chinese medicine preparation of the present invention is: sublimed preparation, powder, injection, plaster, syrup, oral liquid, suck agent, granule, sugar coated tablet, film coated tablet, capsule.

As preferably, present invention also offers the preparation of Chinese medicine preparation, comprise the following steps:

(1) by Radix Ginseng, Radix Codonopsis, the Radix Astragali, Radix Angelicae Sinensis, Flos Carthami, Radix Platycodonis, Fructus Lycii, Rhizoma Chuanxiong, clean, put into container, add 80% ethanol of 1-10 times amount, at 60-100 DEG C of alcoholization 50-120 minute, add the water of 6 times amount again, 75 DEG C of insulations 100 minutes, concentration and recovery ethanol, obtained mixed liquor, filter mixed liquor obtains filtrate, and the Chinese medicine residue of filtration repeats above extraction step; Merge twice filtrate, filtrate concentrates, and at simmer down to 60 DEG C, relative density is the thick paste of 1.10 ~ 1.14 and dry, pulverize powdered, for subsequent use;

(2) by Agkistrodon, Bombyx Batryticatus, Hirudo, Scolopendra, Calculus Bovis, Eupolyphaga Seu Steleophaga, clean, put into container, add 1-8 times amount 75% ethanol, drop in microwave extracting apparatus and carry out microwave extracting, extraction power 1000W, extract 2 times, each 30 minutes, combining extraction liquid, concentrated, be added on DiaionHP-10 macroporous adsorptive resins, 75% ethanol elution, collect 3 times amount column volume eluents, decompression recycling ethanol, concentrated and dry, obtain microwave extraction thing, for subsequent use;

(3) by Radix Tripterygii Wilfordii, Radix Rehmanniae Preparata, Placenta Hominis, Ganoderma, Endothelium Corneum Gigeriae Galli, CO is joined ₂in supercritical extraction device, ethanol is as entrainer, and the percent by volume that entrainer accounts for total extractant is 8%, extracting pressure 20-30MPa, temperature 60 C, CO ₂flow 4ml/g crude drug min, extraction time 100min, obtains supercritical extract, for subsequent use;

(4) Radix Notoginseng, Herba Leonuri, Semen Ziziphi Spinosae, Rhizoma Dioscoreae, Radix Glycyrrhizae are mixed, carry out pulverization process after mix homogeneously, grind into powder, cross 200 order fine powders, for subsequent use;

(5) Poria, Rhizoma Polygoni Cuspidati, Semen Euphorbiae, Spica Prunellae, Radix Bupleuri, Cordyceps, the Radix Paeoniae Alba are put into water and rinse, dry; Proportionally be positioned in super micron mill and pulverize 30 minutes ~ 40 minutes, Chinese medicinal powder after pulverizing is added the soak by water 5 hours of 3 times amount, decoction liquor is filtered, collects filtrate, the soak by water 3 hours relative to its quality 3 times will be added in filtering residue, decoction liquor is filtered, collects filtrate, finally twice filtrate is merged heating and be concentrated into extractum, by extract dry, in super micron mill pulverize 10 minutes ~ 20 minutes, drug powder, for subsequent use;

(6) Fructus Corni, Rhizoma Curcumae Longae, Rhizoma Alismatis, Moschus, Rhizoma Gastrodiae, Pheretima raw material is got by medicine: the Capacity Ratio of water is 1: 2 ~ 10 soak at least 1 hour, add suitable quantity of water again to decoct 1 ~ 5 hour, elimination medicinal residues, under the condition of negative pressure, low temperature, the Chinese medicine leaching liquid of clarification being concentrated into Bomi degree is more than 80%, dry powder (temperature≤100 DEG C of spout) is made by powder spraying apparatus, for subsequent use;

(7) by above-mentioned steps (1), (4), (5), (6) gained mix homogeneously, cross 200 mesh sieves, then be that 25mg/100g adds volume fraction 80% ethanol according to mass ratio, wet granulation, grain graininess 25 order, by obtained granule in 70 DEG C of dry 12h, for subsequent use; Then in the obtained microwave extraction thing of step (2), step (3) and supercritical extract, add the dextrin of 30%, mix homogeneously, then be that 20ml/100g adds volume fraction 95% ethanol according to concentration, make soft material, cross 20 mesh sieves, granulate, grain graininess 25 order, in 60 DEG C of dry 150min, for subsequent use; By above-mentioned two kinds of granule mix homogeneously, add excipient substance, be prepared into corresponding pharmaceutical dosage form.

As preferably, present invention also offers the preparation of Chinese medicine preparation, described tablet preparation comprises the following steps:

(1) by Radix Ginseng, Radix Codonopsis, the Radix Astragali, Radix Angelicae Sinensis, Flos Carthami, Radix Platycodonis, Fructus Lycii, Rhizoma Chuanxiong, clean, put into container, add 80% ethanol of 1-10 times amount, at 60-100 DEG C of alcoholization 50-120 minute, add the water of 6 times amount again, 75 DEG C of insulations 100 minutes, concentration and recovery ethanol, obtained mixed liquor, filter mixed liquor obtains filtrate, and the Chinese medicine residue of filtration repeats above extraction step; Merge twice filtrate, filtrate concentrates, and at simmer down to 60 DEG C, relative density is the thick paste of 1.10 ~ 1.14 and dry, pulverize powdered, for subsequent use;

(2) by Agkistrodon, Bombyx Batryticatus, Hirudo, Scolopendra, Calculus Bovis, Eupolyphaga Seu Steleophaga, clean, put into container, add 1-8 times amount 75% ethanol, drop in microwave extracting apparatus and carry out microwave extracting, extraction power 1000W, extract 2 times, each 30 minutes, combining extraction liquid, concentrated, be added on DiaionHP-10 macroporous adsorptive resins, 75% ethanol elution, collect 3 times amount column volume eluents, decompression recycling ethanol, concentrated and dry, obtain microwave extraction thing, for subsequent use;

(3) by Radix Tripterygii Wilfordii, Radix Rehmanniae Preparata, Placenta Hominis, Ganoderma, Endothelium Corneum Gigeriae Galli, join in CO2 supercritical extraction device, ethanol is as entrainer, the percent by volume that entrainer accounts for total extractant is 8%, extracting pressure 20-30MPa, temperature 60 C, CO2 flow 4ml/g crude drug min, extraction time 100min, obtains supercritical extract, for subsequent use;

(4) Radix Notoginseng, Herba Leonuri, Semen Ziziphi Spinosae, Rhizoma Dioscoreae, Radix Glycyrrhizae are mixed, carry out pulverization process after mix homogeneously, grind into powder, cross 200 order fine powders, for subsequent use;

(5) Poria, Rhizoma Polygoni Cuspidati, Semen Euphorbiae, Spica Prunellae, Radix Bupleuri, Cordyceps, the Radix Paeoniae Alba are put into water and rinse, dry; Proportionally be positioned in super micron mill and pulverize 30 minutes ~ 40 minutes, Chinese medicinal powder after pulverizing is added the soak by water 5 hours of 3 times amount, decoction liquor is filtered, collects filtrate, the soak by water 3 hours relative to its quality 3 times will be added in filtering residue, decoction liquor is filtered, collects filtrate, finally twice filtrate is merged heating and be concentrated into extractum, by extract dry, in super micron mill pulverize 10 minutes ~ 20 minutes, drug powder, for subsequent use;

(6) Fructus Corni, Rhizoma Curcumae Longae, Rhizoma Alismatis, Moschus, Rhizoma Gastrodiae, Pheretima raw material is got by medicine: the Capacity Ratio of water is 1: 2 ~ 10 soak at least 1 hour, add suitable quantity of water again to decoct 1 ~ 5 hour, elimination medicinal residues, under the condition of negative pressure, low temperature, the Chinese medicine leaching liquid of clarification being concentrated into Bomi degree is more than 80%, dry powder (temperature≤100 DEG C of spout) is made by powder spraying apparatus, for subsequent use;

(7) by above-mentioned steps (1), (4), (5), (6) gained mix homogeneously, cross 200 mesh sieves, then be that 25mg/100g adds volume fraction 80% ethanol according to mass ratio, wet granulation, grain graininess 25 order, by obtained granule in 70 DEG C of dry 12h, for subsequent use; Then in the obtained microwave extraction thing of step (2), step (3) and supercritical extract, add the dextrin of 30%, mix homogeneously, then be that 20ml/100g adds volume fraction 95% ethanol according to concentration, make soft material, cross 20 mesh sieves, granulate, grain graininess 25 order, in 60 DEG C of dry 150min, for subsequent use; By above-mentioned two kinds of granule mix homogeneously, add magnesium stearate and carry out tabletting, be prepared into medicinal tablet.

Theoretical foundation of the present invention:

Radix Notoginseng: nature and flavor: sweet micro-hardship, temperature.1. " detailed outline ": " sweet micro-hardship, temperature, nontoxic." 2. " book on Chinese herbal medicine converges and says ": " sweet and slightly bitter taste, property is put down, nontoxic." return through: enter liver, stomach, large intestine channel.Function cures mainly: hemostasis, dissipating blood stasis, detumescence, analgesic therapy.Control haematemesis, hemoptysis, epistaxis, have blood in stool, dysentery, metrorrhagia, lump in the abdomen, puerperal blood faints, retention of lochia, fall and flutter blood stasis, traumatic hemorrhage, carbuncle pain.

Herba Leonuri: nature and flavor: arduous, cool.Gui Jing: enter pericardium, Liver Channel.1. " book on Chinese herbal medicine converges and says ": " hands, meridian of Foot-JUE YIN." 2. " medicineization justice ": " enters liver, spleen, envelope three warp." 3. " book on Chinese herbal medicine is new again ": " enters the heart, spleen, kidney three warp." function cures mainly: invigorate blood circulation, blood stasis dispelling, regulating menstruation, and disappear water.Control menoxenia, vaginal bleeding during pregnancy is had difficult labour, and retention of placenta, puerperal blood faints, abdominal pain due to blood stasis, metrorrhagia and metrostaxis, hematuria, rushes down blood, carbuncle skin infection.

Semen Ziziphi Spinosae: " invigorating middle warmer the liver benefiting, hard muscles and bones help cloudy gas, and all the merit of Semen Ziziphi Spinosae also." record in Ming Dynasty's Li Shizhen (1518-1593 A.D.) Compendium of Material Medica, " insomnia due to insufficiency of the gallbladder-qi in ripe treatment, the disease of excessive thirst sweating due to debility for Semen Ziziphi Spinosae; Life is treated gallbladder-heat and is slept well, and all foot faints cloudy few positive medicine also.

Rhizoma Dioscoreae: nature and flavor: sweet, flat.1. " herbal classic ": sweet in the mouth, temperature.2. " not Lu ": flat, nontoxic.3. " property of medicine class is bright ": sweet in the mouth, cool in nature and moisten.4. " medicineization justice ": survivor is cool in nature, ripe, changing cool is temperature.Gui Jing: enter lung, spleen, kidney channel.1. Materia Medica of Decoction: meridian of Hand-TAI YIN.2. " typhoid fever accumulate want ": to start with, lunar two warps of foot.3. " must book on Chinese herbal medicine be joined ": to start with, meridian of Foot-TAI YIN blood system, double enter meridian of Foot-SHAO YIN edema caused by disorder of QI.

Radix Glycyrrhizae: nature and flavor: sweet, flat.Gui Jing: GUIXIN, lung, spleen, stomach warp.Function cures mainly: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.

Radix Ginseng: nature and flavor: sweet, micro-hardship is flat.Gui Jing: return spleen, lung, heart channel.Function cures mainly: strongly invigorating primordial QI, and multiple arteries and veins takes off admittedly, and invigorating the spleen to benefit the lung, promotes the production of body fluid, and calms the nerves.For weak body and prostration, cold extremities faint pulse, insufficiency of the spleen lack of appetite, the deficiency of the lung is breathed with cough, and Tianjin wound is thirsty, and interior-heat is quenched one's thirst, prolonged illness weakness with emaciation, palpitation with fear insomnia, sexual impotence cold womb; Heart failure, cardiogenic shock.

Radix Codonopsis: nature and flavor: sweet is flat.1. " herbal classic is met former ": " sweet, flat." 2. " book on Chinese herbal medicine is new again ": " is sweet, flat, nontoxic." return through: " must join book on Chinese herbal medicine ": " starts with, meridian of Foot-TAI YIN edema caused by disorder of QI." function cures mainly: invigorating middle warmer, and QI invigorating is promoted the production of body fluid.Control weakness of the spleen and stomach, deficiency of both QI and blood, fatigue and lack of strength, lack of appetite, thirsty, chronic diarrhea, proctoptosis.

The Radix Astragali: nature and flavor: sweet, temperature.Gui Jing: return lung, spleen channel.Function cures mainly: invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.Weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle difficulty is burst, and burst for a long time and do not hold back, blood deficiency dull yellowish colored skin, interior-heat is quenched one's thirst; Chronic nephritis proteinuria, diabetes.

Radix Angelicae Sinensis: nature and flavor: sweet, acrid, warm.Gui Jing: return liver, the heart, spleen channel.Function cures mainly: enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.For blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.Radix Angelicae Sinensis (processed with wine) promoting blood circulation to restore menstrual flow.For amenorrhea dysmenorrhea, rheumatic arthralgia, injury from falling down.

Flos Carthami: nature and flavor: pungent, temperature.1. " Kaibao Bencao ": " pungent, temperature, nontoxic." 2. Materia Medica of Decoction: " pungent and sweet temperature is bitter." return through: enter the heart, Liver Channel.Function cures mainly: promoting blood circulation to restore menstrual flow, blood stasis removing pain relieving.Control amenorrhea, lump in the abdomen, difficult labour, stillborn fetus, disease that postpartum lochia can't go, blood stasis are had a pain, carbuncle, injury from falling down.

Radix Platycodonis: nature and flavor: bitter, pungent is flat.Gui Jing: return lung meridian.Function cures mainly: lung qi dispersing, and sore-throat relieving eliminates the phlegm, evacuation of pus.For cough with copious phlegm, uncomfortable in chest not smooth, pharyngalgia, hoarseness, lung abscess vomiting pus, skin infection difficulty in discharging of pus.

Fructus Lycii: nature and flavor: sweet is flat.1. " not Lu ": " be slightly cold, nontoxic." 2. " property of medicine opinion ": " sweet in the mouth is flat." 3. " Treatise on Dietetic Therapy ": " trembles with fear, nontoxic." return through: enter liver, kidney channel.Function cures mainly: nourishing kidney, lung moistening, tonifying liver, improving eyesight.Control hepatic and renal YIN deficiency, soreness of the waist and knees, dizzy, dizzy, the many tear of blurred vision, cough due to consumptive disease, quenches one's thirst, seminal emission.

Rhizoma Chuanxiong: nature and flavor: pungent, temperature.Gui Jing: return liver, gallbladder, pericardium channel.Function cures mainly: blood-activating and qi-promoting, wind-expelling pain-stopping.For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen is suffered from abdominal pain, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia.

Agkistrodon: nature and flavor: Gan Xian, temperature, poisonous.1. " Kaibao Bencao ": " sweet-salty, temperature, poisonous." 2. " Bencao Tujing ": " is very toxic." return through: enter liver, spleen channel.1. " Thunder God concocts property of medicine solution ": " enter lung, liver two warp." 2. " book on Chinese herbal medicine is new again ": " enters spleen channel." function cures mainly: wind-damp dispelling, and saturating muscles and bones, arresting convulsion is jerked.Dispelling the wind and dampness pathogens is paralysed, and arthralgia, leprosy, mange, infantile convulsion is twitched, tetanus, syphilitic skin lesion, scrofula malignant boil.

Bombyx Batryticatus: nature and flavor: salty, pungent is flat.Gui Jing: return liver, lung, stomach warp.Function cures mainly: expelling wind for relieving convulsion, dissipating phlegm and resolving masses.For convulsion with spasms, laryngopharynx swelling and pain, skin pruritus, submandibular lymph nodes is scorching, facial paralysis.

Hirudo: nature and flavor: salty hardship, flat, poisonous.1. " herbal classic ": " salty in the mouth is flat." 2. " not Lu ": " be bitter, is slightly cold, poisonous.Gui Jing: enter liver, urinary bladder channel.1. " detailed outline ": " Liver Channel blood system." 2. " key medicine divides agent ": " enters liver, bladder two warp." function cures mainly: removing blood stasis, and removing blood stasis stimulates the menstrual flow.Control blood-retention, lump in the abdomen, gather, women's amenorrhea, blood stasis becomes consumptive disease, injury from falling down, and order is pain also, nebula.

Scolopendra: nature and flavor: pungent, temperature; Poisonous.Gui Jing: return Liver Channel.Function cures mainly: endogenous wind stopping spasmolytic, merit poison eliminating stagnation, removing obstruction in the collateral to relieve pain.For infantile convulsion, tic spasm, middle air port is askew, hemiplegia, tetanus, rheumatoid arthritis stubborn, skin infection, scrofula, venom.

Calculus Bovis: nature and flavor: sweet is cool.Gui Jing: GUIXIN, Liver Channel.Function cures mainly: clear away heart-fire, and eliminating phlegm is had one's ideas straightened out, cool liver, endogenous wind stopping, removing toxic substances.For calentura coma, middle wind-phlegm fan, infantile convulsion is twitched, and epilepsy is gone mad, laryngopharynx swelling and pain, aphtha of the mouth and tongue, carbuncle furuncle.

Eupolyphaga Seu Steleophaga: nature and flavor: salty, cold; Slightly poisonous.Gui Jing: return Liver Channel.Function cures mainly: removing blood stasis with potent drugs blood, reuniting the fractured tendons and bones.For injured bone, blood stasis amenorrhea, lump in the abdomen mass in the abdomen.

Bombyx Batryticatus: nature and flavor: salty, pungent is flat.Gui Jing: return liver, lung, stomach warp.Function cures mainly: expelling wind for relieving convulsion, dissipating phlegm and resolving masses.For convulsion with spasms, laryngopharynx swelling and pain, skin pruritus, submandibular lymph nodes is scorching, facial paralysis.

Radix Tripterygii Wilfordii: nature and flavor: bitter; Pungent; Large poison.Gui Jing: the heart; Liver Channel.Function cures mainly: expelling wind and removing dampness; Promoting blood circulation to remove obstruction in the collateral; Reducing swelling and alleviating pain; Parasite killing detoxifies.Main classes rheumatic arthritis; Rheumatic arthritis; Glomerulonephritis; Nephrotic syndrome; Lupus erythematosus; Mouth xerophthalmia scheorma syndrome; Behcet disease; Eczema; Psoriasis; Leprosy; Scabies; Stubborn dermatitis.

Radix Rehmanniae Preparata: nature and flavor: sweet, tepor.Gui Jing: return liver, kidney channel.Function cures mainly: nourishing YIN and supplementing blood, and beneficial essence fills out marrow.For the hepatic and renal YIN deficiency, soreness of the waist and knees, osteopyrexia and fever, night sweat is passed out semen, and interior-heat is quenched one's thirst, blood deficiency and yellow complexion, severe palpitation, menoxenia, and metrostaxis is dizzy, tinnitus, early whitening of beard and hair.

Placenta Hominis: nature and flavor: Gan Xian, temperature.1. " book on Chinese herbal medicine covers bamboo fish trap ": " sweet in the mouth, the large temperature of gas, nontoxic." 2. " detailed outline ": " sweet-salty, temperature, nontoxic." 3. " medical center bun is wanted ": " sweetness and bitterness is salty, temperature." return through: enter lung, liver, kidney channel.Function cures mainly: QI invigorating, nourishes blood, benefit essence.Control deficient, weakness and emaciation, consumptive fever hectic fever due to YIN-deficiency, cough with asthma, spitting of blood, night sweat, seminal emission, sexual impotence, women's vim and vigour are not enough, infertile or newborn few.

Ganoderma: nature and flavor: sweet, flat.Gui Jing: GUIXIN, lung, liver, kidney channel.Function cures mainly: invigorating QI and tranquilization, relieving cough and asthma.For dizzy sleeplessness, shortness of breath and palpitation, asthenia cough with asthma.

Endothelium Corneum Gigeriae Galli: nature and flavor: sweet is flat.Gui Jing: return spleen, stomach, small intestinal, urinary bladder channel.Function cures mainly: invigorating the stomach and promoting digestion, arresting seminal emission.Do not disappear for food stagnation, vomiting dysentery, infantile malnutrition, the enuresis, seminal emission.

Poria: nature and flavor: sweet light is flat.1. " herbal classic ": " sweet in the mouth is flat." 2. " medicine origin ": " " curing mainly secret formula " cloud, warm in nature, lightly seasoned." return through: enter the heart, spleen, lung meridian.Function cures mainly: eliminating dampness and diuresis, strengthening the spleen stomach function regulating, mind tranquilizing and the heart calming.Control dysuria, edema distension, phlegm retention cough with dyspnea, the sound of vomiting of vomitting, has loose bowels, seminal emission, stranguria with turbid discharge, and palpitation with fear is forgetful.

Rhizoma Polygoni Cuspidati: nature and flavor: micro-hardship, is slightly cold.Gui Jing: return liver, gallbladder, lung meridian.Function cures mainly: expelling wind and removing dampness, dissipating blood stasis analgesic therapy, relieving cough and resolving phlegm.For arthralgia, jaundice due to damp-heat, amenorrhea, lump in the abdomen, burn due to hot liquid or fire, injury from falling down, carbuncle sore tumefacting virus, cough with copious phlegm.

Semen Euphorbiae: nature and flavor: pungent, warm; Poisonous.Gui Jing: return liver, kidney, large intestine channel.Function cures mainly: detumescence of relieving oedema or abdominal distension through diuresis or purgation, removing blood stasis eliminating mass.For edema, phlegm retention, stagnant distension, constipation and anuresis, blood stasis amenorrhea; External treatment stubborn dermatitis, warty vegetation.

Spica Prunellae: nature and flavor: pungent, bitter, cold.Gui Jing: return liver, gallbladder meridian.Function cures mainly: relieve inflammation or internal heat, improving eyesight, eliminating stagnation, detumescence.For conjunctival congestion and swelling pain, order pearl nyctalgia, has a headache dizzy, scrofula, goiter, and acute mastitis swells and ache; Thyromegaly, tuberculous lymphadenitis, cyclomastopathy, hypertension.

Radix Bupleuri: nature and flavor: bitter, cool.1. " herbal classic ": " bitter in the mouth is flat." 2. " not Lu ": " be slightly cold, nontoxic." 3. " Japan hanako materia medica ": " sweet in the mouth." return through: enter liver, gallbladder meridian.Function cures mainly: reconciling superficies and interior, soothing the liver, yang invigorating.Control alternate attack of chill and fever, fullness in the chest and hypochondriac pain, bitter taste is deaf, headache and dizziness, malaria, lower sharp proctoptosis, menoxenia, uterine prolapse.

Cordyceps: nature and flavor: sweet, temperature.1. " Bencao Congxin ": " sweet, flat." 2. " property of medicine is examined ": " sweet in the mouth, warm in nature." 3. " book on Chinese herbal medicine is new again ": " is slightly poisonous.The acid of " 4. " Qinghai medical material ": " sweet in the mouth, property is put down, and gas is fragrant." return through: " book on Chinese herbal medicine is new again ": " enters lung, kidney two warp." function cures mainly: tonifying deficiency, beneficial vital essence, relieving cough and resolving phlegm.Control phlegm retention to breathe heavily and cough, dyspnea due to deficiency, consumptive disease is coughed, spitting of blood, spontaneous sweating, impotence and seminal emission, soreness of waist and knee joint, and prolonged deficiency is multiple after being ill.

The Radix Paeoniae Alba: nature and flavor: picric acid is cool.Gui Jing: enter liver, spleen channel.1. " product remittance essence is wanted ": " row hands is lunar, meridian of Foot-TAI YIN." 2. " Bencao Jingshu ": " lunar guiding drug of brothers, enters liver, spleen blood system." function cures mainly: nourishing blood to suppress the hyperactive liver, pain relieving in slow, and yin fluid astringing receives antiperspirant.Control the breast abdomen pain over the hypochondriac region, dysentery is suffered from abdominal pain, spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia.

In sum, the present invention has the advantages such as good effect, cost is low, limitation is little, have no adverse reaction relative to prior art.The present invention serves regulation mechanism balance, elimination thrombosis, reduction cholesterol, vessel softening, conditioning viscera function, conditioning blood pressure, recovers the effects such as human body yin-yang balancing, reduces the three-hypers symptom of human body, effectively treats hemiplegia disease.The present invention uses rear without any side effects in addition, alleviates the misery of people, raising life quality has positive effect.Compare with similar drugs, it is rigorous that medicine of the present invention has compatibility, mild in medicine property and, feature evident in efficacy, treating both the principal and secondary aspects of a disease, is convenient to large scale application clinically.

Detailed description of the invention

Below in conjunction with specific embodiment, the present invention is further elaborated.

Embodiment 1

The raw material composition of effective ingredient of the present invention and parts by weight are: Radix Ginseng 1 part, the Radix Astragali 1 part, Radix Angelicae Sinensis 1 part, Radix Notoginseng 1 part, Agkistrodon 1 part, Bombyx Batryticatus 1 part, Hirudo 1 part, Scolopendra 1 part, Calculus Bovis 1 part, Eupolyphaga Seu Steleophaga 1 part, 1 part, Flos Carthami, Radix Codonopsis 1 part, the Radix Paeoniae Alba 1 part, 3 parts, Radix Glycyrrhizae, Radix Platycodonis 1 part, Radix Tripterygii Wilfordii 1 part, Radix Rehmanniae Preparata 1 part, Herba Leonuri 2 parts, Fructus Lycii 2 parts, Placenta Hominis 2 parts, Rhizoma Dioscoreae 2 parts, Ganoderma 1 part, Semen Ziziphi Spinosae 1 part, Endothelium Corneum Gigeriae Galli 1 part, 1 part, Poria, Rhizoma Polygoni Cuspidati 1 part, Semen Euphorbiae 1 part, Spica Prunellae 1 part, Radix Bupleuri 1 part, Cordyceps 0.5 part, Rhizoma Chuanxiong 1 part, Fructus Corni 1 part, 1 part, Rhizoma Curcumae Longae, Rhizoma Alismatis 1 part, 1 part, Moschus, 1 part, Rhizoma Gastrodiae, Pheretima 1 part.

Said medicine tablet preparation of the present invention comprises the following steps:

(1) by Radix Ginseng, Radix Codonopsis, the Radix Astragali, Radix Angelicae Sinensis, Flos Carthami, Radix Platycodonis, Fructus Lycii, Rhizoma Chuanxiong, clean, put into container, add 80% ethanol of 1-10 times amount, at 60-100 DEG C of alcoholization 50-120 minute, add the water of 6 times amount again, 75 DEG C of insulations 100 minutes, concentration and recovery ethanol, obtained mixed liquor, filter mixed liquor obtains filtrate, and the Chinese medicine residue of filtration repeats above extraction step; Merge twice filtrate, filtrate concentrates, and at simmer down to 60 DEG C, relative density is the thick paste of 1.10 ~ 1.14 and dry, pulverize powdered, for subsequent use;

(2) by Agkistrodon, Bombyx Batryticatus, Hirudo, Scolopendra, Calculus Bovis, Eupolyphaga Seu Steleophaga, clean, put into container, add 1-8 times amount 75% ethanol, drop in microwave extracting apparatus and carry out microwave extracting, extraction power 1000W, extract 2 times, each 30 minutes, combining extraction liquid, concentrated, be added on DiaionHP-10 macroporous adsorptive resins, 75% ethanol elution, collect 3 times amount column volume eluents, decompression recycling ethanol, concentrated and dry, obtain microwave extraction thing, for subsequent use;

(3) by Radix Tripterygii Wilfordii, Radix Rehmanniae Preparata, Placenta Hominis, Ganoderma, Endothelium Corneum Gigeriae Galli, join in CO2 supercritical extraction device, ethanol is as entrainer, the percent by volume that entrainer accounts for total extractant is 8%, extracting pressure 20-30MPa, temperature 60 C, CO2 flow 4ml/g crude drug min, extraction time 100min, obtains supercritical extract, for subsequent use;

(4) Radix Notoginseng, Herba Leonuri, Semen Ziziphi Spinosae, Rhizoma Dioscoreae, Radix Glycyrrhizae are mixed, carry out pulverization process after mix homogeneously, grind into powder, cross 200 order fine powders, for subsequent use;

(5) Poria, Rhizoma Polygoni Cuspidati, Semen Euphorbiae, Spica Prunellae, Radix Bupleuri, Cordyceps, the Radix Paeoniae Alba are put into water and rinse, dry; Proportionally be positioned in super micron mill and pulverize 30 minutes ~ 40 minutes, Chinese medicinal powder after pulverizing is added the soak by water 5 hours of 3 times amount, decoction liquor is filtered, collects filtrate, the soak by water 3 hours relative to its quality 3 times will be added in filtering residue, decoction liquor is filtered, collects filtrate, finally twice filtrate is merged heating and be concentrated into extractum, by extract dry, in super micron mill pulverize 10 minutes ~ 20 minutes, drug powder, for subsequent use;

(6) Fructus Corni, Rhizoma Curcumae Longae, Rhizoma Alismatis, Moschus, Rhizoma Gastrodiae, Pheretima raw material is got by medicine: the Capacity Ratio of water is 1: 2 ~ 10 soak at least 1 hour, add suitable quantity of water again to decoct 1 ~ 5 hour, elimination medicinal residues, under the condition of negative pressure, low temperature, the Chinese medicine leaching liquid of clarification being concentrated into Bomi degree is more than 80%, dry powder (temperature≤100 DEG C of spout) is made by powder spraying apparatus, for subsequent use;

(7) by above-mentioned steps (1), (4), (5), (6) gained mix homogeneously, cross 200 mesh sieves, then be that 25mg/100g adds volume fraction 80% ethanol according to mass ratio, wet granulation, grain graininess 25 order, by obtained granule in 70 DEG C of dry 12h, for subsequent use; Then in the obtained microwave extraction thing of step (2), step (3) and supercritical extract, add the dextrin of 30%, mix homogeneously, then be that 20ml/100g adds volume fraction 95% ethanol according to concentration, make soft material, cross 20 mesh sieves, granulate, grain graininess 25 order, in 60 DEG C of dry 150min, for subsequent use; By above-mentioned two kinds of granule mix homogeneously, add magnesium stearate and carry out tabletting, be prepared into medicinal tablet.

Embodiment 2

The raw material composition of effective ingredient of the present invention and parts by weight are: Radix Ginseng 1 part, the Radix Astragali 1 part, Radix Angelicae Sinensis 1 part, Radix Notoginseng 2 parts, Agkistrodon 1 part, Bombyx Batryticatus 1 part, Hirudo 1 part, Scolopendra 1 part, Calculus Bovis 1 part, Eupolyphaga Seu Steleophaga 1 part, 1 part, Flos Carthami, Radix Codonopsis 1 part, the Radix Paeoniae Alba 1 part, 5 parts, Radix Glycyrrhizae, Radix Platycodonis 2 parts, Radix Tripterygii Wilfordii 2 parts, Radix Rehmanniae Preparata 1 part, Herba Leonuri 3 parts, Fructus Lycii 3 parts, Placenta Hominis 2 parts, Rhizoma Dioscoreae 3 parts, Ganoderma 1 part, Semen Ziziphi Spinosae 3 parts, Endothelium Corneum Gigeriae Galli 1 part, 1 part, Poria, Rhizoma Polygoni Cuspidati 1 part, Semen Euphorbiae 1 part, Spica Prunellae 1 part, Radix Bupleuri 3 parts, Cordyceps 0.5 part, Rhizoma Chuanxiong 1 part, Fructus Corni 1 part, 1 part, Rhizoma Curcumae Longae, Rhizoma Alismatis 2 parts, 1 part, Moschus, 2 parts, Rhizoma Gastrodiae, Pheretima 1 part.

Said medicine tablet preparation process of the present invention is identical with embodiment 1.

Embodiment 3

The raw material composition of effective ingredient of the present invention and parts by weight are: Radix Ginseng 1 part, the Radix Astragali 1 part, Radix Angelicae Sinensis 1 part, Radix Notoginseng 3 parts, Agkistrodon 1 part, Bombyx Batryticatus 1 part, Hirudo 2 parts, Scolopendra 1 part, Calculus Bovis 1 part, Eupolyphaga Seu Steleophaga 1 part, 1 part, Flos Carthami, Radix Codonopsis 1 part, the Radix Paeoniae Alba 1 part, 5 parts, Radix Glycyrrhizae, Radix Platycodonis 1 part, Radix Tripterygii Wilfordii 1 part, Radix Rehmanniae Preparata 1 part, Herba Leonuri 5 parts, Fructus Lycii 5 parts, Placenta Hominis 2 parts, Rhizoma Dioscoreae 2 parts, Ganoderma 2 parts, Semen Ziziphi Spinosae 5 parts, Endothelium Corneum Gigeriae Galli 1 part, 1 part, Poria, Rhizoma Polygoni Cuspidati 1 part, Semen Euphorbiae 1 part, Spica Prunellae 1 part, Radix Bupleuri 3 parts, Cordyceps 0.6 part, Rhizoma Chuanxiong 1 part, Fructus Corni 1 part, 1 part, Rhizoma Curcumae Longae, Rhizoma Alismatis 1 part, 1 part, Moschus, 1 part, Rhizoma Gastrodiae, Pheretima 1 part.

Said medicine tablet preparation process of the present invention is identical with embodiment 1.

Toxicity test:

Laboratory animal

White mice is provided by Qingdao City's laboratory animal and animal experimental center.

Mice lavage administration acute toxicity testing

By 50 white mice in laboratory conditions adaptability feed after 3d, be divided into 2 groups at random, often organizing 25, is experimental group and matched group.After fasting 8h (can't help water), experimental group gives Chinese medicinal tablet of the present invention (tablet dissolved is obtained suspension in the water) gavage as embodiment 3 prepares, and matched group gives normal saline gavage.Observe the situation such as spirit, behavior, diet wish of white mice after gavage in seven days, record mice dying T/A, cuts open the dead white mice of inspection, observes the pathological change of each organs and tissues.Experimental result shows none death of white mice in seven days, and put to death each internal organs of white mice anatomic observation and do not find toxic reaction, experimental group and matched group white mice are without any difference.

Rat oral gavage administration long term toxicity test

Toxicity test:

Choose SD rat 80, be divided into matched group, experimental group often to organize 40, male and female half and half.Matched group adopts normal saline gavage, and experimental group adopts the present embodiment 1 tablet to be scattered in water, gavage, and dosage is 10g (crude drug) kg ^-1(being equivalent to 100 times of adult's medication), three times on the one gavages, successive administration 15 weeks, observes the index such as animal ordinary circumstance and body weight.Drug withdrawal is after three days, and observe the index such as hair, behavior, defecation, body weight of SD rat, result shows all to have no significant effect, and internal organs naked eyes do not find difference change.Put to death rat, tissue slice is carried out to its internal organs, shows without any pathological changes and exception under Electronic Speculum.

Clinical trial:

Case selection:

As the medicine for the treatment of hemiplegia, select the routine clinical observation of hemiplegic patient 83 of making a definite diagnosis, with the Chinese medicine composition of the embodiment of the present invention 3, oral, each 2g, every day 3 times, warm water delivery service after meal; It within 7 days, is 1 course for the treatment of.

Efficacy determination:

2, criterion of therapeutical effect is formulated with reference to " Chinese medicine Clinical Researches of New Drugs guideline ".

Cure: neurological symptom and Signs disappear substantially, life is taken care of oneself completely;

Effective: neurological symptom and Signs major part disappear, and can not stand, living section is taken care of oneself;

Take a turn for the better: neurological symptom and Signs disappear, and support can be stood, and can't take care of oneself;

Invalid: without obviously changing after treatment, or after treatment, symptom and Signs increase the weight of.。

Therapeutic outcome: through the treatment of five courses for the treatment of, in accept for medical treatment 83 routine hemiplegic patients, cures 76 examples, effective 4 examples, invalid 3 examples, cure rate 91.6%, total effective rate 96.4%, determined curative effect, cure rate is high, and patient is over the course for the treatment of without any discomfort, has no side effect.

The above; it is only most preferred embodiment of the present invention; not any pro forma restriction is done to the present invention; any those of ordinary skill in the art; do not departing under technical solution of the present invention ambit; utilize the method content of above-mentioned announcement to make many possible variations and modification to technical solution of the present invention, all belong to the scope of claims protection.

Claims (7)

1. treat a Chinese medicine composition for hemiplegia, it is characterized in that: be made up of following component:

Radix Ginseng, the Radix Astragali, Radix Angelicae Sinensis, Radix Notoginseng, Agkistrodon, Bombyx Batryticatus, Hirudo, Scolopendra, Calculus Bovis, Eupolyphaga Seu Steleophaga, Flos Carthami, Radix Codonopsis, the Radix Paeoniae Alba, Radix Glycyrrhizae, Radix Platycodonis, Radix Tripterygii Wilfordii, Radix Rehmanniae Preparata, Herba Leonuri, Fructus Lycii, Placenta Hominis, Rhizoma Dioscoreae, Ganoderma, Semen Ziziphi Spinosae, Endothelium Corneum Gigeriae Galli, Poria, Rhizoma Polygoni Cuspidati, Semen Euphorbiae, Spica Prunellae, Radix Bupleuri, Cordyceps, Rhizoma Chuanxiong, Fructus Corni, Rhizoma Curcumae Longae, Rhizoma Alismatis, Moschus, Rhizoma Gastrodiae, Pheretima.

2. a kind of Chinese medicine composition for the treatment of hemiplegia according to claim 1, is characterized in that: be made up of each component of following parts by weight:

Radix Ginseng 1-30 part, Radix Astragali 1-30 part, Radix Angelicae Sinensis 1-30 part, Radix Notoginseng 1-30 part, Agkistrodon 1-30 part, Bombyx Batryticatus 1-30 part, Hirudo 1-30 part, Scolopendra 1-30 part, Calculus Bovis 1-30 part, Eupolyphaga Seu Steleophaga 1-30 part, Flos Carthami 1-30 part, Radix Codonopsis 1-30 part, Radix Paeoniae Alba 1-30 part, Radix Glycyrrhizae 1-30 part, Radix Platycodonis 1-30 part, Radix Tripterygii Wilfordii 1-30 part, Radix Rehmanniae Preparata 1-30 part, Herba Leonuri 1-30 part, Fructus Lycii 1-30 part, Placenta Hominis 1-30 part, Rhizoma Dioscoreae 1-30 part, Ganoderma 1-30 part, Semen Ziziphi Spinosae 1-30 part, Endothelium Corneum Gigeriae Galli 1-30 part, Poria 1-30 part, Rhizoma Polygoni Cuspidati 1-30 part, Semen Euphorbiae 1-30 part, Radix Bupleuri 1-30 part, Cordyceps 0.5-30 part, Spica Prunellae 1-30 part, Rhizoma Chuanxiong 1-30 part, Fructus Corni 1-30 part, Rhizoma Curcumae Longae 1-30 part, Rhizoma Alismatis 1-30 part, Moschus 1-30 part, Rhizoma Gastrodiae 1-30 part, Pheretima 1-30 part.

3. a kind of Chinese medicine composition for the treatment of hemiplegia according to claim 2, is characterized in that: be made up of each component of following parts by weight:

Radix Ginseng 1-15 part, Radix Astragali 1-15 part, Radix Angelicae Sinensis 1-15 part, Radix Notoginseng 1-15 part, Agkistrodon 1-15 part, Bombyx Batryticatus 1-15 part, Hirudo 1-15 part, Scolopendra 1-15 part, Calculus Bovis 1-15 part, Eupolyphaga Seu Steleophaga 1-15 part, Flos Carthami 1-15 part, Radix Codonopsis 1-15 part, Radix Paeoniae Alba 1-15 part, Radix Glycyrrhizae 1-15 part, Radix Platycodonis 1-15 part, Radix Tripterygii Wilfordii 1-15 part, Radix Rehmanniae Preparata 1-15 part, Herba Leonuri 1-15 part, Fructus Lycii 1-15 part, Placenta Hominis 1-15 part, Rhizoma Dioscoreae 1-15 part, Ganoderma 1-15 part, Semen Ziziphi Spinosae 1-15 part, Endothelium Corneum Gigeriae Galli 1-15 part, Poria 1-15 part, Rhizoma Polygoni Cuspidati 1-15 part, Semen Euphorbiae 1-15 part, Spica Prunellae 1-15 part, Radix Bupleuri 1-15 part, Cordyceps 0.5-8 part, Rhizoma Chuanxiong 1-15 part, Fructus Corni 1-15 part, Rhizoma Curcumae Longae 1-15 part, Rhizoma Alismatis 1-15 part, Moschus 1-15 part, Rhizoma Gastrodiae 1-15 part, Pheretima 1-15 part.

4. a kind of Chinese medicine composition for the treatment of hemiplegia according to claims 1 to 3, it is characterized in that: each component composition comprising following parts by weight: Radix Ginseng 1-10 part, Radix Astragali 1-10 part, Radix Angelicae Sinensis 1-10 part, Radix Notoginseng 1-10 part, Agkistrodon 1-10 part, Bombyx Batryticatus 1-10 part, Hirudo 1-10 part, Scolopendra 1-10 part, Calculus Bovis 1-10 part, Eupolyphaga Seu Steleophaga 1-10 part, Flos Carthami 1-10 part, Radix Codonopsis 1-10 part, Radix Paeoniae Alba 1-10 part, Radix Glycyrrhizae 1-10 part, Radix Platycodonis 1-10 part, Radix Tripterygii Wilfordii 1-10 part, Radix Rehmanniae Preparata 1-10 part, Herba Leonuri 1-10 part, Fructus Lycii 1-10 part, Placenta Hominis 1-10 part, Rhizoma Dioscoreae 1-10 part, Ganoderma 1-10 part, Semen Ziziphi Spinosae 1-10 part, Endothelium Corneum Gigeriae Galli 1-10 part, Poria 1-10 part, Rhizoma Polygoni Cuspidati 1-10 part, Semen Euphorbiae 1-10 part, Spica Prunellae 1-10 part, Radix Bupleuri 1-10 part, Cordyceps 0.5-8 part, Rhizoma Chuanxiong 1-10 part, Fructus Corni 1-10 part, Rhizoma Curcumae Longae 1-10 part, Rhizoma Alismatis 1-10 part, Moschus 1-10 part, Rhizoma Gastrodiae 1-10 part, Pheretima 1-10 part.

5. a kind of Chinese medicine composition for the treatment of hemiplegia according to claim 1, is characterized in that: the dosage form of described Chinese medicine preparation is: sublimed preparation, powder, injection, plaster, syrup, oral liquid, suck agent, granule, sugar coated tablet, film coated tablet, capsule.

6., according to a kind of preparation method for the treatment of the Chinese medicine composition of hemiplegia described in claim 1 to 5, it is characterized in that: comprising the following steps of preparation:

(1) by Radix Ginseng, Radix Codonopsis, the Radix Astragali, Radix Angelicae Sinensis, Flos Carthami, Radix Platycodonis, Fructus Lycii, Rhizoma Chuanxiong, clean, put into container, add 80% ethanol of 1-10 times amount, at 60-100 DEG C of alcoholization 50-120 minute, add the water of 6 times amount again, 75 DEG C of insulations 100 minutes, concentration and recovery ethanol, obtained mixed liquor, filter mixed liquor obtains filtrate, and the Chinese medicine residue of filtration repeats above extraction step; Merge twice filtrate, filtrate concentrates, and at simmer down to 60 DEG C, relative density is the thick paste of 1.10 ~ 1.14 and dry, pulverize powdered, for subsequent use;

(2) by Agkistrodon, Bombyx Batryticatus, Hirudo, Scolopendra, Calculus Bovis, Eupolyphaga Seu Steleophaga, clean, put into container, add 1-8 times amount 75% ethanol, drop in microwave extracting apparatus and carry out microwave extracting, extraction power 1000W, extract 2 times, each 30 minutes, combining extraction liquid, concentrated, be added on DiaionHP-10 macroporous adsorptive resins, 75% ethanol elution, collect 3 times amount column volume eluents, decompression recycling ethanol, concentrated and dry, obtain microwave extraction thing, for subsequent use;

(3) by Radix Tripterygii Wilfordii, Radix Rehmanniae Preparata, Placenta Hominis, Ganoderma, Endothelium Corneum Gigeriae Galli, CO is joined ₂in supercritical extraction device, ethanol is as entrainer, and the percent by volume that entrainer accounts for total extractant is 8%, extracting pressure 20-30MPa, temperature 60 C, CO ₂flow 4ml/g crude drug min, extraction time 100min, obtains supercritical extract, for subsequent use;

(4) Radix Notoginseng, Herba Leonuri, Semen Ziziphi Spinosae, Rhizoma Dioscoreae, Radix Glycyrrhizae are mixed, carry out pulverization process after mix homogeneously, grind into powder, cross 200 order fine powders, for subsequent use;

(5) Poria, Rhizoma Polygoni Cuspidati, Semen Euphorbiae, Spica Prunellae, Radix Bupleuri, Cordyceps, the Radix Paeoniae Alba are put into water and rinse, dry; Proportionally be positioned in super micron mill and pulverize 30 minutes ~ 40 minutes, Chinese medicinal powder after pulverizing is added the soak by water 5 hours of 3 times amount, decoction liquor is filtered, collects filtrate, the soak by water 3 hours relative to its quality 3 times will be added in filtering residue, decoction liquor is filtered, collects filtrate, finally twice filtrate is merged heating and be concentrated into extractum, by extract dry, in super micron mill pulverize 10 minutes ~ 20 minutes, drug powder, for subsequent use;

(6) Fructus Corni, Rhizoma Curcumae Longae, Rhizoma Alismatis, Moschus, Rhizoma Gastrodiae, Pheretima raw material is got by medicine: the Capacity Ratio of water is 1: 2 ~ 10 soak at least 1 hour, add suitable quantity of water again to decoct 1 ~ 5 hour, elimination medicinal residues, under the condition of negative pressure, low temperature, the Chinese medicine leaching liquid of clarification being concentrated into Bomi degree is more than 80%, dry powder (temperature≤100 DEG C of spout) is made by powder spraying apparatus, for subsequent use;

(7) by above-mentioned steps (1), (4), (5), (6) gained mix homogeneously, cross 200 mesh sieves, then be that 25mg/100g adds volume fraction 80% ethanol according to mass ratio, wet granulation, grain graininess 25 order, by obtained granule in 70 DEG C of dry 12h, for subsequent use; Then in the obtained microwave extraction thing of step (2), step (3) and supercritical extract, add the dextrin of 30%, mix homogeneously, then be that 20ml/100g adds volume fraction 95% ethanol according to concentration, make soft material, cross 20 mesh sieves, granulate, grain graininess 25 order, in 60 DEG C of dry 150min, for subsequent use; By above-mentioned two kinds of granule mix homogeneously, add excipient substance, be prepared into corresponding pharmaceutical dosage form.

7. a kind of preparation method for the treatment of the Chinese medicine composition of hemiplegia according to claim 6, is characterized in that: prepared by described tablet comprises the following steps:

(1) by Radix Ginseng, Radix Codonopsis, the Radix Astragali, Radix Angelicae Sinensis, Flos Carthami, Radix Platycodonis, Fructus Lycii, Rhizoma Chuanxiong, clean, put into container, add 80% ethanol of 1-10 times amount, at 60-100 DEG C of alcoholization 50-120 minute, add the water of 6 times amount again, 75 DEG C of insulations 100 minutes, concentration and recovery ethanol, obtained mixed liquor, filter mixed liquor obtains filtrate, and the Chinese medicine residue of filtration repeats above extraction step; Merge twice filtrate, filtrate concentrates, and at simmer down to 60 DEG C, relative density is the thick paste of 1.10 ~ 1.14 and dry, pulverize powdered, for subsequent use;

(2) by Agkistrodon, Bombyx Batryticatus, Hirudo, Scolopendra, Calculus Bovis, Eupolyphaga Seu Steleophaga, clean, put into container, add 1-8 times amount 75% ethanol, drop in microwave extracting apparatus and carry out microwave extracting, extraction power 1000W, extract 2 times, each 30 minutes, combining extraction liquid, concentrated, be added on DiaionHP-10 macroporous adsorptive resins, 75% ethanol elution, collect 3 times amount column volume eluents, decompression recycling ethanol, concentrated and dry, obtain microwave extraction thing, for subsequent use;

(3) by Radix Tripterygii Wilfordii, Radix Rehmanniae Preparata, Placenta Hominis, Ganoderma, Endothelium Corneum Gigeriae Galli, join in CO2 supercritical extraction device, ethanol is as entrainer, the percent by volume that entrainer accounts for total extractant is 8%, extracting pressure 20-30MPa, temperature 60 C, CO2 flow 4ml/g crude drug min, extraction time 100min, obtains supercritical extract, for subsequent use;

(4) Radix Notoginseng, Herba Leonuri, Semen Ziziphi Spinosae, Rhizoma Dioscoreae, Radix Glycyrrhizae are mixed, carry out pulverization process after mix homogeneously, grind into powder, cross 200 order fine powders, for subsequent use;

(5) Poria, Rhizoma Polygoni Cuspidati, Semen Euphorbiae, Spica Prunellae, Radix Bupleuri, Cordyceps, the Radix Paeoniae Alba are put into water and rinse, dry; Proportionally be positioned in super micron mill and pulverize 30 minutes ~ 40 minutes, Chinese medicinal powder after pulverizing is added the soak by water 5 hours of 3 times amount, decoction liquor is filtered, collects filtrate, the soak by water 3 hours relative to its quality 3 times will be added in filtering residue, decoction liquor is filtered, collects filtrate, finally twice filtrate is merged heating and be concentrated into extractum, by extract dry, in super micron mill pulverize 10 minutes ~ 20 minutes, drug powder, for subsequent use;

(6) Fructus Corni, Rhizoma Curcumae Longae, Rhizoma Alismatis, Moschus, Rhizoma Gastrodiae, Pheretima raw material is got by medicine: the Capacity Ratio of water is 1: 2 ~ 10 soak at least 1 hour, add suitable quantity of water again to decoct 1 ~ 5 hour, elimination medicinal residues, under the condition of negative pressure, low temperature, the Chinese medicine leaching liquid of clarification being concentrated into Bomi degree is more than 80%, dry powder (temperature≤100 DEG C of spout) is made by powder spraying apparatus, for subsequent use;

(7) by above-mentioned steps (1), (4), (5), (6) gained mix homogeneously, cross 200 mesh sieves, then be that 25mg/100g adds volume fraction 80% ethanol according to mass ratio, wet granulation, grain graininess 25 order, by obtained granule in 70 DEG C of dry 12h, for subsequent use; Then in the obtained microwave extraction thing of step (2), step (3) and supercritical extract, add the dextrin of 30%, mix homogeneously, then be that 20ml/100g adds volume fraction 95% ethanol according to concentration, make soft material, cross 20 mesh sieves, granulate, grain graininess 25 order, in 60 DEG C of dry 150min, for subsequent use; By above-mentioned two kinds of granule mix homogeneously, add magnesium stearate and carry out tabletting, be prepared into medicinal tablet.