CN105412859A - Chinese medicine composition for preventing and treating postpartum puerperal fever and preparation method thereof - Google Patents
Chinese medicine composition for preventing and treating postpartum puerperal fever and preparation method thereof Download PDFInfo
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- CN105412859A CN105412859A CN201510836473.XA CN201510836473A CN105412859A CN 105412859 A CN105412859 A CN 105412859A CN 201510836473 A CN201510836473 A CN 201510836473A CN 105412859 A CN105412859 A CN 105412859A
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- radix
- rhizoma
- fructus
- chinese medicine
- ethanol
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Abstract
The invention relates to the field of traditional Chinese medicine, in particular to a Chinese medicine composition for preventing and treating a postpartum puerperal fever. The Chinese medicine composition is composed of milkvetch roots, a sheep placenta, pseudo-ginseng, Chinese angelica, peach kernels, ligusticum chuanxiong Hort, liquorice roots, motherwort, glossy privet fruits, Chinese yams, gymnadenia conopsea, lilies, garden balsam stems, folium artemisiae argyi, wolfberries, cinnamomum cassia, mangnolia officinalis, poria cocos, balloon flowers, saposhnikovia divaricata (Trucz.) schischk, houttuynia cordata and donkey-hide gelatin. Compared with the prior art, the Chinese medicine composition has the advantages of being good in treatment effect, low in cost, small in limitation, free of adverse effects and others, and can accelerate body recovery of a lying-in woman, prevent gynecological diseases, repair the birth canal, relieve dysmenorrhea, promote uterine contraction, activate blood circulation, stop bleeding, diminish inflammations, achieve sterilization and prevent and treat the postpartum puerperal fever of the lying-in woman. The Chinese medicine composition further has the advantages of being precise in compatibility, mild in medicine property and remarkable in treatment effect and is convenient to apply and popularize clinically on a large scale.
Description
Technical field
The invention belongs to technical field of traditional Chinese pharmacology, be specifically related to Chinese medicine composition of a kind of prevention and therapy puerperal fever in puerperal and preparation method thereof.
Background technology
Within puerperal, there are limbs or joint is miserable, pain, numbness in puerpera, is called " puerperal general pain ", is commonly called as " puerperal exposure to wind ".Be also called " pantalgia after delivery ", " arthralgia in puerperal ", " post partum paralysis ", " puerperal arthralgia ".Be equivalent to the rheumatism of doctor trained in Western medicine, arthralgia that rheumatoid causes, puerperal sciatica, the similar symptom that occurs of polymyositis, postpartum thrombophlebitis.
The women of child-bearing age are not before bearing child, health there is no any disease, and after marriage or after artificial abortion, especially after artificial abortion, due to childbirth time cause product wound and hemorrhage, can cause that puerpera's vigour is impaired, immune dysfunction, premunition are weak, if now health preserving is careless, numerous disease will be following, is commonly called as puerperal disease, cry again " puerperal fever ", and puerperal disease is difficult to cure.Record in the gynecological doctor nationality "Fu Qingzhu works on obstetric" that China is famous: " all diseases arise from declining of vim and vigour, the void of taste, and puerperal more so ", also illustrate that the hazardness of puerperal disease.
The pathogeny of puerperal fever, can be summarized as three classes: one is thin fluid injury, and blood deficiency fire is dynamic; But congestion internal resistance, the absurd row of deteriorated blood; Three is diseases caused by exogenous pathogenic factor six climate exopathogens, or diet exhaustion due to sexual indulgence hindered.But the pathogenesis of most root wood is: cloudy blood is suddenly empty, YANG transmission is floating loose, thus causes various disease; In addition, puerperal hypogalactia, directly impact is neonatal especially grows up healthy and sound.Improving the pure breast milk rate of feeding is one of the objective of the struggle in the whole world, and breast milk is nutritious, and the most applicable baby digests and assimilates, and includes panimmunity material, can strengthen the resistance against diseases of baby, and thus breast milk is the most desirable neonatal safest food.There are different folk prescription, the prescription of preventing and treating puerperal fever and promotion galactopoiesis in current all parts of the country, but very different, and mouthfeel is poor, and puerpera is difficult to adhere to taking, and what have even has bad side effect.
Summary of the invention
In order to overcome deficiency of the prior art, the invention provides a kind of Chinese medicine composition of prevention and therapy puerperal fever in puerperal, to puerperal fever, there is significant curative effect.
In order to solve the problems of the technologies described above, the technical solution used in the present invention is as follows: a kind of Chinese medicine composition of prevention and therapy puerperal fever in puerperal, is made up of following component:
The Radix Astragali, Placenta caprae seu ovis, Radix Notoginseng, Radix Angelicae Sinensis, Semen Persicae, Rhizoma Chuanxiong, Radix Glycyrrhizae, Herba Leonuri, Fructus Ligustri Lucidi, Rhizoma Dioscoreae, Rhizoma Gymnadeniae, Bulbus Lilii, Herba speranskiae tuberculatae, Folium Artemisiae Argyi, Fructus Lycii, Cortex Cinnamomi, Cortex Magnoliae Officinalis, Poria, Radix Platycodonis, Radix Saposhnikoviae, Herba Houttuyniae, Colla Corii Asini, Radix Polygoni Multiflori, the Rhizoma Atractylodis Macrocephalae, Radix Rehmanniae Preparata, Radix Rubiae, Rhizoma Zingiberis, Rhizoma Cyperi, Flos Lonicerae, Radix Achyranthis Bidentatae, Semen Ziziphi Spinosae, Fructus Mume, Fructus Jujubae, Rhizoma Polygonati, Semen Cassiae.
Further, the present invention is made up of each component of following parts by weight:
Radix Astragali 1-30 part, Placenta caprae seu ovis 1-30 part, Radix Notoginseng 1-30 part, Radix Angelicae Sinensis 1-30 part, Semen Persicae 1-30 part, Rhizoma Chuanxiong 1-30 part, Radix Glycyrrhizae 1-30 part, Herba Leonuri 1-30 part, Fructus Ligustri Lucidi 1-30 part, Rhizoma Dioscoreae 1-30 part, Rhizoma Gymnadeniae 1-30 part, Bulbus Lilii 1-30 part, Herba speranskiae tuberculatae 1-30 part, Folium Artemisiae Argyi 1-30 part, Fructus Lycii 1-30 part, Cortex Cinnamomi 1-30 part, Cortex Magnoliae Officinalis 1-30 part, Poria 1-30 part, Radix Platycodonis 1-30 part, Radix Saposhnikoviae 1-30 part, Herba Houttuyniae 1-30 part, Colla Corii Asini 1-30 part, Radix Polygoni Multiflori 1-30 part, Rhizoma Atractylodis Macrocephalae 1-30 part, Radix Rehmanniae Preparata 1-30 part, Radix Rubiae 1-30 part, Rhizoma Zingiberis 1-30 part, Rhizoma Cyperi 1-30 part, Flos Lonicerae 1-30 part, Radix Achyranthis Bidentatae 1-30 part, Semen Ziziphi Spinosae 1-30 part, Fructus Mume 1-30 part, Fructus Jujubae 1-30 part, Rhizoma Polygonati 1-30 part, Semen Cassiae 1-30 part.
Further, the present invention is made up of each component of following parts by weight:
Radix Astragali 1-15 part, Placenta caprae seu ovis 1-15 part, Radix Notoginseng 1-15 part, Radix Angelicae Sinensis 1-15 part, Semen Persicae 1-15 part, Rhizoma Chuanxiong 1-15 part, Radix Glycyrrhizae 1-15 part, Herba Leonuri 1-15 part, Fructus Ligustri Lucidi 1-15 part, Rhizoma Dioscoreae 1-15 part, Rhizoma Gymnadeniae 1-15 part, Bulbus Lilii 1-15 part, Herba speranskiae tuberculatae 1-15 part, Folium Artemisiae Argyi 1-15 part, Fructus Lycii 1-15 part, Cortex Cinnamomi 1-15 part, Cortex Magnoliae Officinalis 1-15 part, Poria 1-15 part, Radix Platycodonis 1-15 part, Radix Saposhnikoviae 1-15 part, Herba Houttuyniae 1-15 part, Colla Corii Asini 1-15 part, Radix Polygoni Multiflori 1-15 part, Rhizoma Atractylodis Macrocephalae 1-15 part, Radix Rehmanniae Preparata 1-15 part, Radix Rubiae 1-15 part, Rhizoma Zingiberis 1-15 part, Rhizoma Cyperi 1-15 part, Flos Lonicerae 1-15 part, Radix Achyranthis Bidentatae 1-15 part, Semen Ziziphi Spinosae 1-15 part, Fructus Mume 1-15 part, Fructus Jujubae 1-15 part, Rhizoma Polygonati 1-15 part, Semen Cassiae 1-15 part.
Further, the present invention also comprises each component composition of following parts by weight: three branch and leaf 1-20 parts, Fructus Trichosanthis 1-20 part, Flos Rosae Rugosae 1-20 part, Semen Astragali Complanati 1-20 part, Rhizoma Acori Graminei 1-20 part.
Further, the dosage form of Chinese medicine preparation of the present invention is: tablet, dispersible tablet, capsule, patch, ointment, oral liquid, powder, granule.
Further, the preparation method of the Chinese medicine composition of a kind of prevention and therapy of the present invention puerperal fever in puerperal, it comprises the following steps:
(1) Radix Astragali, Radix Notoginseng, Radix Angelicae Sinensis, Semen Persicae, Rhizoma Chuanxiong, Herba Leonuri, Fructus Ligustri Lucidi, Rhizoma Dioscoreae, Rhizoma Gymnadeniae, Bulbus Lilii, Herba speranskiae tuberculatae are cleaned, put into container, add 75% ethanol of 3 times amount, drop in microwave extracting apparatus and carry out microwave extracting, extraction power 1000W, extract 3 times, each 30 minutes, combining extraction liquid, concentrated, be added on DiaionHP-10 macroporous adsorptive resins, 75% ethanol elution, collect 5 times amount column volume eluents, decompression recycling ethanol, concentrated and dry, obtain microwave extraction thing, for subsequent use;
(2) by Folium Artemisiae Argyi, Fructus Lycii, Cortex Cinnamomi, Cortex Magnoliae Officinalis, Poria, CO is joined
2in supercritical extraction device, ethanol is as entrainer, and the percent by volume that entrainer accounts for total extractant is 5%, extracting pressure 20-30MPa, temperature 55 DEG C, CO
2flow 3.5ml/g crude drug min, extraction time 160min, obtains supercritical extract, for subsequent use;
(3) Radix Rehmanniae Preparata, Radix Platycodonis, Radix Saposhnikoviae, Herba Houttuyniae, Radix Polygoni Multiflori, the Rhizoma Atractylodis Macrocephalae, Radix Rubiae, Rhizoma Zingiberis, the broken coarse powder of making of Rhizoma Cyperi are put in extractor, add dimethyl sulfoxide moistening again, carry out circumfluence distillation adding after water adds a cover 36 hours, the extracting solution extracted being added active carbon adopts centrifuge to carry out solid-liquid separation decolouring removing dimethyl sulfoxide, the starch inside extracting solution is removed, pectin at membrane filtration; Add Polyethylene Glycol again, tween 80 potassium hydroxide, hydroxyethyl-cellulose, ethanol, static 8 hours of germall bp, centrifugalize is at normal temperatures decoloured, and obtains precipitate, and dry powder is for subsequent use;
(4) Flos Lonicerae, Radix Achyranthis Bidentatae, Semen Ziziphi Spinosae, Fructus Mume, Rhizoma Polygonati, Semen Cassiae are cleaned, put into container, add 80% ethanol of 1-10 times amount, at 60-100 DEG C of alcoholization 50-120 minute, then add the water of 6 times amount, 75 DEG C of insulations 100 minutes, concentration and recovery ethanol, obtain mixed liquor, filter mixed liquor obtains filtrate, and the Chinese medicine residue of filtration repeats above extraction step; Merge twice filtrate, with aperture at 1000um, molecular cut off is in the high temperature resistant high rejection rolling NF membrane of 300KDalton, isolate the large particulate matter in filtrate and supernatant, supernatant concentration, at simmer down to 60 DEG C, relative density is the thick paste of 1.10 ~ 1.14 and dry, pulverize powdered, for subsequent use;
(5) Placenta caprae seu ovis, Radix Glycyrrhizae, Colla Corii Asini, Fructus Jujubae will be pulverized with super micron mill, make cell breakage, obtain micronizing powder;
(6) by three branch and leaf, Fructus Trichosanthis, Flos Rosae Rugosae, Semen Astragali Complanati, Rhizoma Acori Graminei, decoct with 3-5 deionized water doubly, repeat decoction 3 times, each 60min, collect decoction liquor, filter, decoction liquor is concentrated, obtains extractum, by extractum vacuum drying, pulverize to obtain powder;
(7) by above-mentioned steps (1), (2), (3), (4), (5), (6) gained mix homogeneously, then add excipient substance, be prepared into corresponding pharmaceutical dosage form.
Further, the preparation method of the Chinese medicine composition of a kind of prevention and therapy of the present invention puerperal fever in puerperal, described capsule preparation comprises the following steps:
(1) Radix Astragali, Radix Notoginseng, Radix Angelicae Sinensis, Semen Persicae, Rhizoma Chuanxiong, Herba Leonuri, Fructus Ligustri Lucidi, Rhizoma Dioscoreae, Rhizoma Gymnadeniae, Bulbus Lilii, Herba speranskiae tuberculatae are cleaned, put into container, add 75% ethanol of 3 times amount, drop in microwave extracting apparatus and carry out microwave extracting, extraction power 1000W, extract 3 times, each 30 minutes, combining extraction liquid, concentrated, be added on DiaionHP-10 macroporous adsorptive resins, 75% ethanol elution, collect 5 times amount column volume eluents, decompression recycling ethanol, concentrated and dry, obtain microwave extraction thing, for subsequent use;
(2) by Folium Artemisiae Argyi, Fructus Lycii, Cortex Cinnamomi, Cortex Magnoliae Officinalis, Poria, CO is joined
2in supercritical extraction device, ethanol is as entrainer, and the percent by volume that entrainer accounts for total extractant is 5%, extracting pressure 20-30MPa, temperature 55 DEG C, CO
2flow 3.5ml/g crude drug min, extraction time 160min, obtains supercritical extract, for subsequent use;
(3) Radix Rehmanniae Preparata, Radix Platycodonis, Radix Saposhnikoviae, Herba Houttuyniae, Radix Polygoni Multiflori, the Rhizoma Atractylodis Macrocephalae, Radix Rubiae, Rhizoma Zingiberis, the broken coarse powder of making of Rhizoma Cyperi are put in extractor, add dimethyl sulfoxide moistening again, carry out circumfluence distillation adding after water adds a cover 36 hours, the extracting solution extracted being added active carbon adopts centrifuge to carry out solid-liquid separation decolouring removing dimethyl sulfoxide, the starch inside extracting solution is removed, pectin at membrane filtration; Add Polyethylene Glycol again, tween 80 potassium hydroxide, hydroxyethyl-cellulose, ethanol, static 8 hours of germall bp, centrifugalize is at normal temperatures decoloured, and obtains precipitate, and dry powder is for subsequent use;
(4) Flos Lonicerae, Radix Achyranthis Bidentatae, Semen Ziziphi Spinosae, Fructus Mume, Rhizoma Polygonati, Semen Cassiae are cleaned, put into container, add 80% ethanol of 1-10 times amount, at 60-100 DEG C of alcoholization 50-120 minute, then add the water of 6 times amount, 75 DEG C of insulations 100 minutes, concentration and recovery ethanol, obtain mixed liquor, filter mixed liquor obtains filtrate, and the Chinese medicine residue of filtration repeats above extraction step; Merge twice filtrate, with aperture at 1000um, molecular cut off is in the high temperature resistant high rejection rolling NF membrane of 300KDalton, isolate the large particulate matter in filtrate and supernatant, supernatant concentration, at simmer down to 60 DEG C, relative density is the thick paste of 1.10 ~ 1.14 and dry, pulverize powdered, for subsequent use;
(5) Placenta caprae seu ovis, Radix Glycyrrhizae, Colla Corii Asini, Fructus Jujubae will be pulverized with super micron mill, make cell breakage, obtain micronizing powder;
(6) by three branch and leaf, Fructus Trichosanthis, Flos Rosae Rugosae, Semen Astragali Complanati, Rhizoma Acori Graminei, decoct with 3-5 deionized water doubly, repeat decoction 3 times, each 60min, collect decoction liquor, filter, decoction liquor is concentrated, obtains extractum, by extractum vacuum drying, pulverize to obtain powder;
(7) by above-mentioned steps (1), (2), (3), (4), (5), (6) gained mix homogeneously, add adhesive again, carry out soft material granulation, granule is dried, add capsule adjuvant, after be distributed into capsule and be finished product, every capsules powder charge is about 10mg.
Theoretical foundation of the present invention:
The Radix Astragali: nature and flavor: sweet, temperature.Gui Jing: return lung, spleen channel.Function cures mainly: invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.Weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle difficulty is burst, and burst for a long time and do not hold back, blood deficiency dull yellowish colored skin, interior-heat is quenched one's thirst; Chronic nephritis proteinuria, diabetes.
Radix Notoginseng: nature and flavor: sweet micro-hardship, temperature.1. " detailed outline ": " sweet micro-hardship, temperature, nontoxic." 2. " book on Chinese herbal medicine converges and says ": " sweet and slightly bitter taste, property is put down, nontoxic." return through: enter liver, stomach, large intestine channel.1. " book on Chinese herbal medicine converges and says ": " enter bright, the JUE YIN meridian of sun." 2. " book on Chinese herbal medicine is looked for the truth ": " enters liver, stomach, double enter the heart, large intestine." 3. " book on Chinese herbal medicine is new again ": " enters lung, kidney two warp." function cures mainly: hemostasis, dissipating blood stasis, detumescence, analgesic therapy.Control haematemesis, hemoptysis, epistaxis, have blood in stool, dysentery, metrorrhagia, lump in the abdomen, puerperal blood faints, retention of lochia, fall and flutter blood stasis, traumatic hemorrhage, carbuncle pain.
Radix Angelicae Sinensis: nature and flavor: sweet, acrid, warm.1. " herbal classic ": " sweet in the mouth, temperature." 2. " WU Pu Bencao ": " legendary god of farming, Yellow Emperor, a legendary ruler, paulownia monarch, Bian Que: sweet, nontoxic.Qi primary, Thunder God: pungent, nontoxic.Li Shi: little temperature." return through: enter the heart, liver, spleen channel.1. Materia Medica of Decoction: " few the moon of starting with, lunar, the JUE YIN meridian of foot." 2. " Thunder God concocts property of medicine solution ": " enters the heart, liver, lung three warp." function cures mainly: benefiting blood and regulating blood circulation, and menstruction regulating and pain relieving moisturizes laxation.Control menoxenia, amenorrhea is suffered from abdominal pain, and lump in the abdomen knot is poly-, metrorrhagia; Headache due to deficiency of blood, dizzy, flaccidity syndrome and arthralgia syndrome; Dryness of the intestine dyschezia is heavy after bloody dysentery; Carbuncle skin ulcer is stolen, injury from falling down.
Semen Persicae: nature and flavor: bitter sweet is flat.1. " herbal classic ": " bitter in the mouth is flat." 2. " not Lu ": " be sweet, nontoxic." 3. " a thousand pieces of gold dietetic therapy ": " bitter but sweet flavor is pungent, flat, nontoxic." return through: enter the heart, liver, large intestine channel.1. Materia Medica of Decoction: " start with, meridian of Foot-JUE YIN." 2. " Thunder God concocts property of medicine solution ": " enters liver, large intestine two warp." 3. " book on Chinese herbal medicine is through separating ": " enters lung meridian, heart channel of Hand-Shaoyin, spleen meridian." function cures mainly: blood stasis removing and clots absorbing, moisturizes laxation.Control amenorrhea, lump in the abdomen, calentura blood-retention, migratory arthralgia, malaria, traumatic injury, swelling and pain due to blood stasis, the dry constipation of blood.
Rhizoma Chuanxiong: nature and flavor: pungent, temperature.Gui Jing: return liver, gallbladder, pericardium channel.Function cures mainly: blood-activating and qi-promoting, wind-expelling pain-stopping.For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen is suffered from abdominal pain, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia.
Herba Leonuri: nature and flavor: arduous, cool.1. supplement to the Herbal: " cold." 2. " book on Chinese herbal medicine covers bamboo fish trap ": " acrid-sweet flavor, feeble QI temperature, nontoxic." 3. " detailed outline ": " micro-hardship of acrid in the mouth, nontoxic." 4. " book on Chinese herbal medicine just ": " mildly bitter flavor, micro-pungent.Be slightly cold, property is sliding." return through: enter pericardium, Liver Channel.Function cures mainly: invigorate blood circulation, blood stasis dispelling, regulating menstruation, and disappear water.Control menoxenia, vaginal bleeding during pregnancy is had difficult labour, and retention of placenta, puerperal blood faints, abdominal pain due to blood stasis, metrorrhagia and metrostaxis, hematuria, rushes down blood, carbuncle skin infection.
Fructus Ligustri Lucidi: nature and flavor: bitter sweet, flat.1. " herbal classic ": " bitter in the mouth is flat." 2. " not Lu ": " be sweet, nontoxic." return through: enter liver, kidney channel.1. " Bencao Jingshu ": " enter meridian of Foot-SHAO YIN." 2. " book on Chinese herbal medicine is new again ": " enters liver, lung, kidney three warp." function cures mainly: invigorating the liver and kidney, strong waist knee joint.Control yin asthenia generating intrinsic heat, dizzy, order flower, tinnitus, soreness of the waist and knees, early whitening of beard and hair.Nourishing the liver and kidney, improving eyesight black hair.For vertigo and tinnitus, soreness of the waist and knees, early whitening of beard and hair, poor vision.
Rhizoma Dioscoreae: nature and flavor: sweet, flat.Gui Jing: return spleen, lung, kidney channel.Function cures mainly: spleen reinforcing nourishing the stomach, and promote the production of body fluid lung benefiting, the kidney invigorating arresting seminal emission.For insufficiency of the spleen lack of appetite, incessant chronic diarrhea, the deficiency of the lung is breathed with cough, emission due to deficiency of the kidney, leukorrhagia, frequent micturition, and deficiency-heat is quenched one's thirst.Rhizoma Dioscoreae (parched with bran) spleen reinforcing stomach invigorating.For insufficiency of the spleen lack of appetite, loose stool of having loose bowels, leukorrhagia.
Rhizoma Gymnadeniae: nature and flavor: sweet; Flat.Gui Jing: lung; Spleen; Stomach warp.Function cures mainly: relieving cough and asthma; Yishen Jianpi; Regulate the flow of vital energy and blood; Pain relieving.Main cough and asthma due to lung deficiency; Asthenia is become thin; Neurasthenia; Suffer from a deficiency of the kidney lassitude loin and legs; Sexual impotence; Spermatorrhea; Frequent micturition; Chronic hepatitis; Chronic diarrhea; Lose blood; Leukorrhagia; Breast is few; Traumatic injury.
Bulbus Lilii: nature and flavor: sweet micro-hardship, flat.1. " herbal classic): " sweet in the mouth is flat." 2. " not Lu ": " be nontoxic." 3. herbal for Relief of Famines: " sweet in the mouth is pungent, flat." 4. " Changsha medicine solution ": " sweet and slightly bitter taste, is slightly cold." return through: enter the heart, lung meridian.Function cures mainly: nourishing the lung to arrest cough, clearing away heart-fire for tranquillization.Control lung expense chronic cough, cough and spit expectorant blood; After calentura, waste heat comes clear, and fidgets due to deficiency is palpitated with fear, staring spells; Beriberi edema.
Herba speranskiae tuberculatae: nature and flavor: pungent; Warm in nature.Gui Jing: lung; Liver Channel.Function cures mainly: expelling wind and removing dampness; Relaxing muscles and tendons to promote blood circulation; Dissipating blood stasis for subsidence of swelling; Removing toxic substances ophthalmalgia.Main air pain of dampness syndrome; Muscles and bones contracture; The disturbance of lower legs due to pathogenic cold and dampness; Lumbar strain; Paralysis; Amenorrhea; Eczema scrotum; Furuncle toxic swelling.
Folium Artemisiae Argyi: nature and flavor: pungent, bitter, temperature; Slightly poisonous.Gui Jing: return liver,spleen,kidney warp.Function cures mainly: dispersing cold for relieving pain, warming the meridian for stopping bleeding.For few abdomen cold type of pain, coldness and unbalance in meridians, cold womb is infertile, spit blood, epistaxis, metrorrhagia through many, gestation hemorrhage; External treatment skin pruritus.Vinegar Chinese mugwort charcoal warming the meridian for stopping bleeding.Hemorrhage for deficient cold type.
Fructus Lycii: nature and flavor: sweet, flat.1. " not Lu ": " be slightly cold, nontoxic." 2. " property of medicine opinion ": " sweet in the mouth is flat." 3. " Treatise on Dietetic Therapy ": " trembles with fear, nontoxic." return through: enter liver, kidney channel.Function cures mainly: nourishing kidney, lung moistening, tonifying liver, improving eyesight.Control hepatic and renal YIN deficiency, soreness of the waist and knees, dizzy, dizzy, the many tear of blurred vision, cough due to consumptive disease, quenches one's thirst, seminal emission.
Cortex Cinnamomi: nature and flavor: pungent, sweet, hot greatly.Gui Jing: return kidney, spleen, the heart, Liver Channel.Function cures mainly: mend fire supporing yang, let the fire back to its origin, dispersing cold for relieving pain, promoting blood circulation to restore menstrual flow.For sexual impotence, cold womb, chills and pain of the waist and kness, suffers from a deficiency of the kidney and breathes heavily, dizziness due to yang deficiency, conjunctival congestion pharyngalgia, trusted subordinate's cold type of pain, and deficiency and coldness is vomited and diarrhoea, colic of cold type, renal mass, amenorrhea, dysmenorrhea.
Cortex Magnoliae Officinalis: nature and flavor: toil, temperature.1. " herbal classic ": " bitter in the mouth, temperature." 2. " not Lu ": " temperature greatly, nontoxic." 3. " property of medicine opinion ": " bitter in the mouth is pungent, too hot." return through: enter spleen, stomach, large intestine channel.Function cures mainly: warming middle-JIAO, the therapeutic method to keep the adverse QI flowing downwards, dampness, expectorant.Control breast abdomen feeling of fullness distending pain, regurgitation, vomiting, dyspepsia does not disappear, and phlegm retention is breathed with cough, cold-damp dysentery.
Poria: nature and flavor: sweet light is flat.1. " herbal classic ": " sweet in the mouth is flat." 2. " medicine origin ": " " curing mainly secret formula " cloud, warm in nature, lightly seasoned." return through: enter the heart, spleen, lung meridian.1. Materia Medica of Decoction: " start with large cloudy, the large sun of foot, shaoyang channel." 2. " book on Chinese herbal medicine covers bamboo fish trap ": " enters bladder, kidney, lung." function cures mainly: eliminating dampness and diuresis, strengthening the spleen stomach function regulating, mind tranquilizing and the heart calming.Control dysuria, edema distension, phlegm retention cough with dyspnea, the sound of vomiting of vomitting, has loose bowels, seminal emission, stranguria with turbid discharge, and palpitation with fear is forgetful.
Flos Lonicerae: nature and flavor: sweet, cold.1. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " cold in nature, bitter in the mouth." 2. " book on Chinese herbal medicine just ": " sweet in the mouth, gas is put down, its cold nature." return through: enter lung, stomach warp.1. " Thunder God concocts property of medicine solution ": " enter lung meridian." 2. " must join book on Chinese herbal medicine ": " enters bright, the Taiyin channels of foot sun." function cures mainly: heat clearing away, removing toxic substances.Control epidemic febrile disease heating, toxic-heat and blood stasis, carbuncle and ulcer, toxic swelling, scrofula, anal fistula.
Radix Achyranthis Bidentatae: nature and flavor: bitter, sour is flat.Gui Jing: return liver, kidney channel.Function cures mainly: invigorating the liver and kidney, bone and muscle strengthening, eliminating blood stasis and inducing menstruation, conducting blood to flow downwards.For soreness of waist and knee joint, muscles and bones is unable, amenorrhea lump in the abdomen, dizziness due to hyperactivity of liver-YANG.
Semen Ziziphi Spinosae: nature and flavor: sweet, sour is flat.Gui Jing: return liver, gallbladder, heart channel.Function cures mainly: tonifying liver, mind calming, and arresting sweating promotes the production of body fluid.For restlessness of asrhenia type and insomnia, palpitation with fear dreaminess, the empty hyperhidrosis of body, Tianjin wound is thirsty.
Fructus Mume: nature and flavor: acid, temperature.1. " herbal classic ": " sour in the mouth is flat." 2. " not Lu ": " be nontoxic." 3. " Japan hanako materia medica ": " warms up, nontoxic." 4. " medicine origin ": " gas is trembled with fear, sour in the mouth." return through: enter liver, spleen, lung, large intestine channel.Function cures mainly: convergence is promoted the production of body fluid, relieving colic caused by ascaris anthelmintic.Control chronic cough, deficiency-heat excessive thirst, chronic malaria, chronic diarrhea, dysentery, has blood in stool, hematuria, metrorrhagia, ascariasis of biliary tract stomachache, vomiting, ancylostomiasis, psoriasis, bulbar conjunctiva polyp.
Rhizoma Polygonati: nature and flavor: ' sweet, flat.Gui Jing: return spleen, lung, kidney channel.Function cures mainly: boosting qi and nourishing yin, spleen invigorating, lung moistening, kidney tonifying.For weakness of the spleen and stomach, fatigue and asthenia, xerostomia lack of appetite, deficiency of the lung cough caused by dryness, asthenia of essence and blood, interior-heat is quenched one's thirst.
Semen Cassiae: nature and flavor: bitter sweet, cool.1. " herbal classic ": " salty in the mouth is flat." 2. " not Lu ": " be bitter sweet, is slightly cold, nontoxic." 3. " book on Chinese herbal medicine just ": " mildly bitter flavor is micro-sweet, and property is put down, micro-cool." return through: enter liver, kidney channel.1. " Thunder God concocts property of medicine solution ": " enter Liver Channel." 2. " Bencao Jingshu ": " liver meridian, also enters gallbladder, kidney." function cures mainly: liver heat removing, improving eyesight, diuretic, relieving constipation.Control wind heat acute conjunctivitis, optic atrohic blindness, nyctalopia, hypertension, hepatitis, cirrhotic ascites, habitual constipation.
Semen Astragali Complanati: nature and flavor: sweet, temperature.1. " detailed outline ": " sweet, temperature, nontoxic." 2. " book on Chinese herbal medicine converges and says ": " sweet in the mouth is held concurrently bitter." return through: enter liver, kidney channel.1. " explaining abstruseness of the canon of materia medica ": " walk kidney, liver two warp." 2. " book on Chinese herbal medicine is new again ": " enters the heart, kidney two warp." function cures mainly: tonifying liver, kidney tonifying, improving eyesight, controlling nocturnal emission with astringent drugs.Treating the liver kidney deficiency, soreness of waist and knee joint, blurred vision, seminal emission premature ejaculation, frequent micturition, the enuresis, hematuria, leucorrhea.
Rhizoma Acori Graminei: nature and flavor: pungent, tepor, 1. " herbal classic ": " pungent, temperature." 2. " another mouth record ": " is nontoxic." 3. " property of medicine opinion ": " bitter in the mouth is pungent, nontoxic." return through entrance, liver, spleen channel.1. " detailed outline ": " few cloudy, sufficient the moon of fainting of hands." 2. " Thunder God concocts property of medicine solution ": " enters the heart, spleen, bladder three warp." 3. " book on Chinese herbal medicine is through separating ": " enters liver channel of foot-Jueyin, lung meridian." function cures mainly: have one's ideas straightened out, and eliminating phlegm is regulated the flow of vital energy, and invigorates blood circulation, and loose wind, dries.Control epilepsy, syncope due to accumulation of phlegm, calentura coma, forgetful, deafness with qi stagnation, ambition is unhappy, stomachache, stomachache, anemofrigid-damp arthralgia, swollen ulcer drug, traumatic injury.
Placenta caprae seu ovis: sheep placental extract is rich in the nutrition such as multiple proteins, essential amino acids, nucleic acid, hormone unit, collagen, immune factor and calcium ferrum zinc.Have magical beauty treatment and anti-aging effects, Placenta extract contains chlorine polysaccharide body and multiple glandular hormone, can benefiting qi and nourishing blood, reinforcing kidney to replenish kidney essence, radioprotective, antiallergic, returns of spring of preserving youthful looks, whitening and softening skin, maintenance build, be regarded as magical nourishing sage product.
Radix Glycyrrhizae: for insufficiency of heart-QI, severe palpitation, irregularly intermittent and regularly intermittent pulse, and deficiency of spleen-QI and stomach-QI, fatigue and weakness etc.The former, normal and Ramulus Cinnamomi compatibility, as Ramuli Cinnamomi and Glycyrrhizae Decoction, zhigancao decoction.The latter, is often equal to use with Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, as ball in decoction of four noble drugs, reason etc.For ulcer sores, laryngopharynx swelling and pain etc.Can be alone, for oral administration or external application, or compatibility application.Ulcer sores, is often equal to use with Flos Lonicerae, Fructus Forsythiae, plays the merit of heat-clearing and toxic substances removing altogether, as Xian fang Huoming Yin.Laryngopharynx swelling and pain, the normal and same use of Radix Platycodonis, as Radix Platycodonis decoction.If pesticide, alimentary toxicosis, often join Semen phaseoli radiati or be decocted in water for oral dose with Radix Saposhnikoviae.For asthma and cough.Can be alone, also can the application of compatibility other drug.As controlled the ERCHEN TANG of cough due to damp-phlegm; Control the Linggan Wuwei Jiangxin Tang of cold-phlegm cough with asthma; Control the sangxing decoction of dry stool phlegm cough; Control pyretic toxicity and cause lung abscess cough and spit and to smell as of rotten fish the Radix Platycodonis decoction of purulent sputum; Control the Gancao Ganjiang soup etc. of cough and spit saliva foam.The also Chang Peiwu application of another cough due to pathogenic wind-heat, cough due to wind and cold, phlegm heat cough.
Colla Corii Asini: the good medicine moisturized for tonifying blood and arresting bleeding, taste *.Clinical practice is spat blood in blood deficiency beach wormwood Huang, unable, the vexed insomnia of dizzy cardiopalmus, flesh flaccidity, stirring-up of pathogenic wind in the interior resulting from deficiency, xeropulmonary cough, phthisical cough, spit blood, the aspects such as metrorrhagia of having blood in stool have significant curative effect.Colla Corii Asini has hematosis, the nourishing of the anemia that can be used for losing blood, iron deficiency anemia, aplastic anemia and old, child, women.And to the growth promoter of children and adolescents, there is improvement result.Long-term taking Colla Corii Asini, also can skin nutrition, makes the bright and clean lubricious and tool elasticity of skin.
Fructus Jujubae: nature and flavor: sweet, temperature.Gui Jing: return spleen, stomach warp.Function cures mainly: really (Fructus Jujubae): invigorating the spleen and replenishing QI, nourishing blood to tranquillize the mind.For insufficiency of the spleen lack of appetite, weak loose stool, woman hysteria.Bark: antiinflammatory, hemostasis, antidiarrheal.For tracheitis, enteritis, dysentery, metrorrhagia; Traumatic hemorrhage is controlled in external.Root: circulation of qi promoting, invigorates blood circulation, regulating menstruation.For menoxenia, redly to collapse, leucorrhea.
In sum, the present invention has the advantages such as good effect, cost is low, limitation is little, have no adverse reaction relative to prior art.The present invention can accelerate the speed of puerpera's physical recovery, prophylaxis of gynaecological disorders, repairs birth canal, relieving dysmenorrhea, promotes uterine contraction, invigorates blood circulation, stops blooding, anti-inflammation and sterilization, prevention and therapy puerperal fever of puerpera.Compare with similar drugs, it is rigorous that medicine of the present invention has compatibility, mild in medicine property and, feature evident in efficacy, is convenient to large scale application clinically.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is further elaborated.
Embodiment 1
Comprise following components by weight percent: the Radix Astragali 1 part, Placenta caprae seu ovis 1 part, Radix Notoginseng 1 part, Radix Angelicae Sinensis 1 part, 1 part, Semen Persicae, Rhizoma Chuanxiong 1 part, 1 part, Radix Glycyrrhizae, Herba Leonuri 3 parts, Fructus Ligustri Lucidi 1 part, Rhizoma Dioscoreae 2 parts, Rhizoma Gymnadeniae 1 part, Bulbus Lilii 1 part, Herba speranskiae tuberculatae 1 part, Folium Artemisiae Argyi 1 part, Fructus Lycii 5 parts, Cortex Cinnamomi 1 part, Cortex Magnoliae Officinalis 1 part, 1 part, Poria, Radix Platycodonis 1 part, Radix Saposhnikoviae 1 part, Herba Houttuyniae 1 part, 1 part, Colla Corii Asini, Radix Polygoni Multiflori 1 part, the Rhizoma Atractylodis Macrocephalae 1 part, Radix Rehmanniae Preparata 1 part, 1 part, Radix Rubiae, Rhizoma Zingiberis 1 part, Rhizoma Cyperi 1 part, Flos Lonicerae 1 part, Radix Achyranthis Bidentatae 1 part, Semen Ziziphi Spinosae 2 parts, Fructus Mume 2 parts, 4 parts, Fructus Jujubae, Rhizoma Polygonati 1 part, Semen Cassiae 1 part.
The dosage form of Chinese medicine preparation described in the present embodiment is capsule.
The preparation method of the present embodiment, comprises the following steps:
(1) Radix Astragali, Radix Notoginseng, Radix Angelicae Sinensis, Semen Persicae, Rhizoma Chuanxiong, Herba Leonuri, Fructus Ligustri Lucidi, Rhizoma Dioscoreae, Rhizoma Gymnadeniae, Bulbus Lilii, Herba speranskiae tuberculatae are cleaned, put into container, add 75% ethanol of 3 times amount, drop in microwave extracting apparatus and carry out microwave extracting, extraction power 1000W, extract 3 times, each 30 minutes, combining extraction liquid, concentrated, be added on DiaionHP-10 macroporous adsorptive resins, 75% ethanol elution, collect 5 times amount column volume eluents, decompression recycling ethanol, concentrated and dry, obtain microwave extraction thing, for subsequent use;
(2) by Folium Artemisiae Argyi, Fructus Lycii, Cortex Cinnamomi, Cortex Magnoliae Officinalis, Poria, CO is joined
2in supercritical extraction device, ethanol is as entrainer, and the percent by volume that entrainer accounts for total extractant is 5%, extracting pressure 20-30MPa, temperature 55 DEG C, CO
2flow 3.5ml/g crude drug min, extraction time 160min, obtains supercritical extract, for subsequent use;
(3) Radix Rehmanniae Preparata, Radix Platycodonis, Radix Saposhnikoviae, Herba Houttuyniae, Radix Polygoni Multiflori, the Rhizoma Atractylodis Macrocephalae, Radix Rubiae, Rhizoma Zingiberis, the broken coarse powder of making of Rhizoma Cyperi are put in extractor, add dimethyl sulfoxide moistening again, carry out circumfluence distillation adding after water adds a cover 36 hours, the extracting solution extracted being added active carbon adopts centrifuge to carry out solid-liquid separation decolouring removing dimethyl sulfoxide, the starch inside extracting solution is removed, pectin at membrane filtration; Add Polyethylene Glycol again, tween 80 potassium hydroxide, hydroxyethyl-cellulose, ethanol, static 8 hours of germall bp, centrifugalize is at normal temperatures decoloured, and obtains precipitate, and dry powder is for subsequent use;
(4) Flos Lonicerae, Radix Achyranthis Bidentatae, Semen Ziziphi Spinosae, Fructus Mume, Rhizoma Polygonati, Semen Cassiae are cleaned, put into container, add 80% ethanol of 1-10 times amount, at 60-100 DEG C of alcoholization 50-120 minute, then add the water of 6 times amount, 75 DEG C of insulations 100 minutes, concentration and recovery ethanol, obtain mixed liquor, filter mixed liquor obtains filtrate, and the Chinese medicine residue of filtration repeats above extraction step; Merge twice filtrate, with aperture at 1000um, molecular cut off is in the high temperature resistant high rejection rolling NF membrane of 300KDalton, isolate the large particulate matter in filtrate and supernatant, supernatant concentration, at simmer down to 60 DEG C, relative density is the thick paste of 1.10 ~ 1.14 and dry, pulverize powdered, for subsequent use;
(5) Placenta caprae seu ovis, Radix Glycyrrhizae, Colla Corii Asini, Fructus Jujubae will be pulverized with super micron mill, make cell breakage, obtain micronizing powder;
(6) by above-mentioned steps (1), (2), (3), (4), (5) gained mix homogeneously, add adhesive again, carry out soft material granulation, granule is dried, add capsule adjuvant, after be distributed into capsule and be finished product, every capsules powder charge is about 10mg.
Embodiment 2
Comprise following components by weight percent: the Radix Astragali 1 part, Placenta caprae seu ovis 0.5 part, Radix Notoginseng 1 part, Radix Angelicae Sinensis 1 part, 1 part, Semen Persicae, Rhizoma Chuanxiong 1 part, 3 parts, Radix Glycyrrhizae, Herba Leonuri 5 parts, Fructus Ligustri Lucidi 1 part, Rhizoma Dioscoreae 4 parts, Rhizoma Gymnadeniae 2 parts, Bulbus Lilii 1 part, Herba speranskiae tuberculatae 1 part, Folium Artemisiae Argyi 2 parts, Fructus Lycii 5 parts, Cortex Cinnamomi 1 part, Cortex Magnoliae Officinalis 1 part, 1 part, Poria, Radix Platycodonis 2 parts, Radix Saposhnikoviae 1 part, Herba Houttuyniae 1 part, 1 part, Colla Corii Asini, Radix Polygoni Multiflori 1 part, the Rhizoma Atractylodis Macrocephalae 1 part, Radix Rehmanniae Preparata 1 part, 1 part, Radix Rubiae, Rhizoma Zingiberis 1 part, Rhizoma Cyperi 1 part, Flos Lonicerae 2 parts, Radix Achyranthis Bidentatae 1 part, Semen Ziziphi Spinosae 2 parts, Fructus Mume 2 parts, 4 parts, Fructus Jujubae, Rhizoma Polygonati 1 part, Semen Cassiae 3 parts.
The preparation method of the present embodiment, comprises the following steps:
(1) Radix Astragali, Radix Notoginseng, Radix Angelicae Sinensis, Semen Persicae, Rhizoma Chuanxiong, Herba Leonuri, Fructus Ligustri Lucidi, Rhizoma Dioscoreae, Rhizoma Gymnadeniae, Bulbus Lilii, Herba speranskiae tuberculatae are cleaned, put into container, add 75% ethanol of 3 times amount, drop in microwave extracting apparatus and carry out microwave extracting, extraction power 1000W, extract 3 times, each 30 minutes, combining extraction liquid, concentrated, be added on DiaionHP-10 macroporous adsorptive resins, 75% ethanol elution, collect 5 times amount column volume eluents, decompression recycling ethanol, concentrated and dry, obtain microwave extraction thing, for subsequent use;
(2) by Folium Artemisiae Argyi, Fructus Lycii, Cortex Cinnamomi, Cortex Magnoliae Officinalis, Poria, CO is joined
2in supercritical extraction device, ethanol is as entrainer, and the percent by volume that entrainer accounts for total extractant is 5%, extracting pressure 20-30MPa, temperature 55 DEG C, CO
2flow 3.5ml/g crude drug min, extraction time 160min, obtains supercritical extract, for subsequent use;
(3) Radix Rehmanniae Preparata, Radix Platycodonis, Radix Saposhnikoviae, Herba Houttuyniae, Radix Polygoni Multiflori, the Rhizoma Atractylodis Macrocephalae, Radix Rubiae, Rhizoma Zingiberis, the broken coarse powder of making of Rhizoma Cyperi are put in extractor, add dimethyl sulfoxide moistening again, carry out circumfluence distillation adding after water adds a cover 36 hours, the extracting solution extracted being added active carbon adopts centrifuge to carry out solid-liquid separation decolouring removing dimethyl sulfoxide, the starch inside extracting solution is removed, pectin at membrane filtration; Add Polyethylene Glycol again, tween 80 potassium hydroxide, hydroxyethyl-cellulose, ethanol, static 8 hours of germall bp, centrifugalize is at normal temperatures decoloured, and obtains precipitate, and dry powder is for subsequent use;
(4) Flos Lonicerae, Radix Achyranthis Bidentatae, Semen Ziziphi Spinosae, Fructus Mume, Rhizoma Polygonati, Semen Cassiae are cleaned, put into container, add 80% ethanol of 1-10 times amount, at 60-100 DEG C of alcoholization 50-120 minute, then add the water of 6 times amount, 75 DEG C of insulations 100 minutes, concentration and recovery ethanol, obtain mixed liquor, filter mixed liquor obtains filtrate, and the Chinese medicine residue of filtration repeats above extraction step; Merge twice filtrate, with aperture at 1000um, molecular cut off is in the high temperature resistant high rejection rolling NF membrane of 300KDalton, isolate the large particulate matter in filtrate and supernatant, supernatant concentration, at simmer down to 60 DEG C, relative density is the thick paste of 1.10 ~ 1.14 and dry, pulverize powdered, for subsequent use;
(5) Placenta caprae seu ovis, Radix Glycyrrhizae, Colla Corii Asini, Fructus Jujubae will be pulverized with super micron mill, make cell breakage, obtain micronizing powder;
(6) by above-mentioned steps (1), (2), (3), (4), (5) gained mix homogeneously, add adhesive again, carry out soft material granulation, granule is dried, add additive of tablet, upper tablet machine is pressed into tablet, and every tablet is 0.1g.
Embodiment 3
Comprise following components by weight percent: the Radix Astragali 1 part, Placenta caprae seu ovis 0.5 part, Radix Notoginseng 1 part, Radix Angelicae Sinensis 1 part, 1 part, Semen Persicae, Rhizoma Chuanxiong 1 part, 3 parts, Radix Glycyrrhizae, Herba Leonuri 4 parts, Fructus Ligustri Lucidi 1 part, Rhizoma Dioscoreae 4 parts, Rhizoma Gymnadeniae 2 parts, Bulbus Lilii 1 part, Herba speranskiae tuberculatae 1 part, Folium Artemisiae Argyi 3 parts, Fructus Lycii 4 parts, Cortex Cinnamomi 1 part, Cortex Magnoliae Officinalis 1 part, 2 parts, Poria, Radix Platycodonis 2 parts, Radix Saposhnikoviae 1 part, Herba Houttuyniae 1 part, 1 part, Colla Corii Asini, Radix Polygoni Multiflori 1 part, the Rhizoma Atractylodis Macrocephalae 1 part, Radix Rehmanniae Preparata 1 part, 1 part, Radix Rubiae, Rhizoma Zingiberis 1 part, Rhizoma Cyperi 1 part, Flos Lonicerae 2 parts, Radix Achyranthis Bidentatae 2 parts, Semen Ziziphi Spinosae 3 parts, Fructus Mume 3 parts, 3 parts, Fructus Jujubae, Rhizoma Polygonati 1 part, Semen Cassiae 3 parts, three 3 parts, branch and leaf, Fructus Trichosanthis 3 parts, Flos Rosae Rugosae 3 parts, Semen Astragali Complanati 3 parts, Rhizoma Acori Graminei 3 parts.
The preparation method of the present embodiment, comprises the following steps:
(1) Radix Astragali, Radix Notoginseng, Radix Angelicae Sinensis, Semen Persicae, Rhizoma Chuanxiong, Herba Leonuri, Fructus Ligustri Lucidi, Rhizoma Dioscoreae, Rhizoma Gymnadeniae, Bulbus Lilii, Herba speranskiae tuberculatae are cleaned, put into container, add 75% ethanol of 3 times amount, drop in microwave extracting apparatus and carry out microwave extracting, extraction power 1000W, extract 3 times, each 30 minutes, combining extraction liquid, concentrated, be added on DiaionHP-10 macroporous adsorptive resins, 75% ethanol elution, collect 5 times amount column volume eluents, decompression recycling ethanol, concentrated and dry, obtain microwave extraction thing, for subsequent use;
(2) by Folium Artemisiae Argyi, Fructus Lycii, Cortex Cinnamomi, Cortex Magnoliae Officinalis, Poria, CO is joined
2in supercritical extraction device, ethanol is as entrainer, and the percent by volume that entrainer accounts for total extractant is 5%, extracting pressure 20-30MPa, temperature 55 DEG C, CO
2flow 3.5ml/g crude drug min, extraction time 160min, obtains supercritical extract, for subsequent use;
(3) Radix Rehmanniae Preparata, Radix Platycodonis, Radix Saposhnikoviae, Herba Houttuyniae, Radix Polygoni Multiflori, the Rhizoma Atractylodis Macrocephalae, Radix Rubiae, Rhizoma Zingiberis, the broken coarse powder of making of Rhizoma Cyperi are put in extractor, add dimethyl sulfoxide moistening again, carry out circumfluence distillation adding after water adds a cover 36 hours, the extracting solution extracted being added active carbon adopts centrifuge to carry out solid-liquid separation decolouring removing dimethyl sulfoxide, the starch inside extracting solution is removed, pectin at membrane filtration; Add Polyethylene Glycol again, tween 80 potassium hydroxide, hydroxyethyl-cellulose, ethanol, static 8 hours of germall bp, centrifugalize is at normal temperatures decoloured, and obtains precipitate, and dry powder is for subsequent use;
(4) Flos Lonicerae, Radix Achyranthis Bidentatae, Semen Ziziphi Spinosae, Fructus Mume, Rhizoma Polygonati, Semen Cassiae are cleaned, put into container, add 80% ethanol of 1-10 times amount, at 60-100 DEG C of alcoholization 50-120 minute, then add the water of 6 times amount, 75 DEG C of insulations 100 minutes, concentration and recovery ethanol, obtain mixed liquor, filter mixed liquor obtains filtrate, and the Chinese medicine residue of filtration repeats above extraction step; Merge twice filtrate, with aperture at 1000um, molecular cut off is in the high temperature resistant high rejection rolling NF membrane of 300KDalton, isolate the large particulate matter in filtrate and supernatant, supernatant concentration, at simmer down to 60 DEG C, relative density is the thick paste of 1.10 ~ 1.14 and dry, pulverize powdered, for subsequent use;
(5) Placenta caprae seu ovis, Radix Glycyrrhizae, Colla Corii Asini, Fructus Jujubae will be pulverized with super micron mill, make cell breakage, obtain micronizing powder;
(6) by three branch and leaf, Fructus Trichosanthis, Flos Rosae Rugosae, Semen Astragali Complanati, Rhizoma Acori Graminei, decoct with 3-5 deionized water doubly, repeat decoction 3 times, each 60min, collect decoction liquor, filter, decoction liquor is concentrated, obtains extractum, by extractum vacuum drying, pulverize to obtain powder;
(7) by above-mentioned steps (1), (2), (3), (4), (5), (6) gained mix homogeneously, add adhesive again, carry out soft material granulation, granule is dried, add powder adjuvant, rear subpackage becomes finished product, and often bag medicine is about containing 10mg effective ingredient.
Toxicity test:
Laboratory animal
White mice is provided by Qingdao City's laboratory animal and animal experimental center.
Mice lavage administration acute toxicity testing
By 50 white mice in laboratory conditions adaptability feed after 3d, be divided into 2 groups at random, often organizing 25, is experimental group and matched group.After fasting 8h (can't help water), experimental group gives capsule of the present invention (capsule dissolves is obtained suspension in the water) gavage as embodiment 1 prepares, and matched group gives normal saline gavage.Observe the situation such as spirit, behavior, diet wish of white mice after gavage in seven days, record mice dying T/A, cuts open the dead white mice of inspection, observes the pathological change of each organs and tissues.Experimental result shows none death of white mice in seven days, and put to death each internal organs of white mice anatomic observation and do not find toxic reaction, experimental group and matched group white mice are without any difference.
Rat oral gavage administration long term toxicity test
Toxicity test:
Choose SD rat 80, be divided into matched group, experimental group often to organize 40, male and female half and half.Matched group adopts normal saline gavage, and experimental group adopts the present embodiment 1 capsules disperse in water, gavage, and dosage is 10g (crude drug) kg
-1(being equivalent to 100 times of adult's medication), three times on the one gavages, successive administration 15 weeks, observes the index such as animal ordinary circumstance and body weight.Drug withdrawal is after three days, and observe the index such as hair, behavior, defecation, body weight of SD rat, result shows all to have no significant effect, and internal organs naked eyes do not find difference change.Put to death rat, tissue slice is carried out to its internal organs, shows without any pathological changes and exception under Electronic Speculum.
Clinical trial:
Case selection:
Year November wood invention Clinical Selection in March, 2014 to 2015 puerpera 200 example; Wherein the oldest 40, minimum 20 years old, normal labor 90 example, broken abdomen produced 110 examples.
Diagnostic criteria: the symptoms such as puerperal is dizzy, head is heavy or pain, waist, knee, ankle, wrist etc. are numb, sore, emit cold sweat, health feels cold, shiver, meet cold, wind, the pain increased for rainy weather.There is congestion in uterus, reduces the function of genitals and urinary system, affect the blood circulation of lower limb.With numbness, twitch, symptoms such as distending pain or with size arthralgia, the symptoms such as headache.
Criterion of therapeutical effect: effective: after taking a rear course for the treatment of, puerperal fever symptom is clearly better, takes and namely returns to one's perfect health, and do not recur in 1 year two courses for the treatment of.Effective: after taking rear three courses for the treatment of, puerperal fever symptom is clearly better, take and namely return to one's perfect health 6 courses for the treatment of, and do not recur in 1 year.Invalid: after taking latter two course for the treatment of, puerperal fever symptom is bright unchanged.
Therapeutic process: the medicine of Example 1 is treated, one day twice, once two one week is a course for the treatment of, one after each meal.
Therapeutic outcome: the present invention treats 200 examples, effective 98 examples, effective 89 examples, invalid 13 examples, total effective rate 93.5%.
Model case:
Wang, 28 years old, occur after cesarean being afraid of cold, outside aversion to wind, movable joint pain also with symptoms such as numbness, tic, distending pains, take embodiments of the invention 1, every day 3 times, each two, through 1 week, malaise symptoms improves, and continues to take 2 weeks, rehabilitation and not recurring so far.
Peng, 32 years old, after natural labor, not just, lower limb not only aches but also numb, dare not see wind, and arm aches fiber crops equally in official holiday, knee joint and chiralgia, weak from head to foot, have sexual intercourse and have blood, dare not eat cool, take embodiments of the invention 1, every day 3 times, each two, through 1 week, malaise symptoms improves, continue to take 3 weeks, rehabilitation and not recurring so far.
Liu, 32 years old, after natural labor, dizzy, head is heavy, waist, knee, ankle, wrist etc. are numb, sore, emit cold sweat, health feels cold, shiver, and takes embodiments of the invention 1, every day 3 times, each two, through 1 week, malaise symptoms improves, continue to take 2 weeks, rehabilitation and not recurring so far.
The above; it is only most preferred embodiment of the present invention; not any pro forma restriction is done to the present invention; any those of ordinary skill in the art; do not departing under technical solution of the present invention ambit; utilize the method content of above-mentioned announcement to make many possible variations and modification to technical solution of the present invention, all belong to the scope of claims protection.
Claims (7)
1. a Chinese medicine composition for prevention and therapy puerperal fever in puerperal, is characterized in that: be made up of following component:
The Radix Astragali, Placenta caprae seu ovis, Radix Notoginseng, Radix Angelicae Sinensis, Semen Persicae, Rhizoma Chuanxiong, Radix Glycyrrhizae, Herba Leonuri, Fructus Ligustri Lucidi, Rhizoma Dioscoreae, Rhizoma Gymnadeniae, Bulbus Lilii, Herba speranskiae tuberculatae, Folium Artemisiae Argyi, Fructus Lycii, Cortex Cinnamomi, Cortex Magnoliae Officinalis, Poria, Radix Platycodonis, Radix Saposhnikoviae, Herba Houttuyniae, Colla Corii Asini, Radix Polygoni Multiflori, the Rhizoma Atractylodis Macrocephalae, Radix Rehmanniae Preparata, Radix Rubiae, Rhizoma Zingiberis, Rhizoma Cyperi, Flos Lonicerae, Radix Achyranthis Bidentatae, Semen Ziziphi Spinosae, Fructus Mume, Fructus Jujubae, Rhizoma Polygonati, Semen Cassiae.
2. the Chinese medicine composition of a kind of prevention and therapy puerperal fever in puerperal according to claim 1, is characterized in that: be made up of each component of following parts by weight:
Radix Astragali 1-30 part, Placenta caprae seu ovis 1-30 part, Radix Notoginseng 1-30 part, Radix Angelicae Sinensis 1-30 part, Semen Persicae 1-30 part, Rhizoma Chuanxiong 1-30 part, Radix Glycyrrhizae 1-30 part, Herba Leonuri 1-30 part, Fructus Ligustri Lucidi 1-30 part, Rhizoma Dioscoreae 1-30 part, Rhizoma Gymnadeniae 1-30 part, Bulbus Lilii 1-30 part, Herba speranskiae tuberculatae 1-30 part, Folium Artemisiae Argyi 1-30 part, Fructus Lycii 1-30 part, Cortex Cinnamomi 1-30 part, Cortex Magnoliae Officinalis 1-30 part, Poria 1-30 part, Radix Platycodonis 1-30 part, Radix Saposhnikoviae 1-30 part, Herba Houttuyniae 1-30 part, Colla Corii Asini 1-30 part, Radix Polygoni Multiflori 1-30 part, Rhizoma Atractylodis Macrocephalae 1-30 part, Radix Rehmanniae Preparata 1-30 part, Radix Rubiae 1-30 part, Rhizoma Zingiberis 1-30 part, Rhizoma Cyperi 1-30 part, Flos Lonicerae 1-30 part, Radix Achyranthis Bidentatae 1-30 part, Semen Ziziphi Spinosae 1-30 part, Fructus Mume 1-30 part, Fructus Jujubae 1-30 part, Rhizoma Polygonati 1-30 part, Semen Cassiae 1-30 part.
3., according to the Chinese medicine composition of a kind of prevention and therapy puerperal fever in puerperal described in claim 1 to 2, it is characterized in that: be made up of each component of following parts by weight:
Radix Astragali 1-15 part, Placenta caprae seu ovis 1-15 part, Radix Notoginseng 1-15 part, Radix Angelicae Sinensis 1-15 part, Semen Persicae 1-15 part, Rhizoma Chuanxiong 1-15 part, Radix Glycyrrhizae 1-15 part, Herba Leonuri 1-15 part, Fructus Ligustri Lucidi 1-15 part, Rhizoma Dioscoreae 1-15 part, Rhizoma Gymnadeniae 1-15 part, Bulbus Lilii 1-15 part, Herba speranskiae tuberculatae 1-15 part, Folium Artemisiae Argyi 1-15 part, Fructus Lycii 1-15 part, Cortex Cinnamomi 1-15 part, Cortex Magnoliae Officinalis 1-15 part, Poria 1-15 part, Radix Platycodonis 1-15 part, Radix Saposhnikoviae 1-15 part, Herba Houttuyniae 1-15 part, Colla Corii Asini 1-15 part, Radix Polygoni Multiflori 1-15 part, Rhizoma Atractylodis Macrocephalae 1-15 part, Radix Rehmanniae Preparata 1-15 part, Radix Rubiae 1-15 part, Rhizoma Zingiberis 1-15 part, Rhizoma Cyperi 1-15 part, Flos Lonicerae 1-15 part, Radix Achyranthis Bidentatae 1-15 part, Semen Ziziphi Spinosae 1-15 part, Fructus Mume 1-15 part, Fructus Jujubae 1-15 part, Rhizoma Polygonati 1-15 part, Semen Cassiae 1-15 part.
4. the Chinese medicine composition of a kind of prevention and therapy puerperal fever in puerperal according to claims 1 to 3, is characterized in that: each component composition also comprising following parts by weight: three branch and leaf 1-20 parts, Fructus Trichosanthis 1-20 part, Flos Rosae Rugosae 1-20 part, Semen Astragali Complanati 1-20 part, Rhizoma Acori Graminei 1-20 part.
5. the Chinese medicine composition of a kind of prevention and therapy puerperal fever in puerperal according to Claims 1-4, is characterized in that: the dosage form of described Chinese medicine preparation is: tablet, dispersible tablet, capsule, patch, ointment, oral liquid, powder, granule.
6., according to the preparation method of the Chinese medicine composition of a kind of prevention and therapy puerperal fever in puerperal described in claim 1 to 5, it is characterized in that: comprising the following steps of preparation:
(1) Radix Astragali, Radix Notoginseng, Radix Angelicae Sinensis, Semen Persicae, Rhizoma Chuanxiong, Herba Leonuri, Fructus Ligustri Lucidi, Rhizoma Dioscoreae, Rhizoma Gymnadeniae, Bulbus Lilii, Herba speranskiae tuberculatae are cleaned, put into container, add 75% ethanol of 3 times amount, drop in microwave extracting apparatus and carry out microwave extracting, extraction power 1000W, extract 3 times, each 30 minutes, combining extraction liquid, concentrated, be added on DiaionHP-10 macroporous adsorptive resins, 75% ethanol elution, collect 5 times amount column volume eluents, decompression recycling ethanol, concentrated and dry, obtain microwave extraction thing, for subsequent use;
(2) by Folium Artemisiae Argyi, Fructus Lycii, Cortex Cinnamomi, Cortex Magnoliae Officinalis, Poria, CO is joined
2in supercritical extraction device, ethanol is as entrainer, and the percent by volume that entrainer accounts for total extractant is 5%, extracting pressure 20-30MPa, temperature 55 DEG C, CO
2flow 3.5ml/g crude drug min, extraction time 160min, obtains supercritical extract, for subsequent use;
(3) Radix Rehmanniae Preparata, Radix Platycodonis, Radix Saposhnikoviae, Herba Houttuyniae, Radix Polygoni Multiflori, the Rhizoma Atractylodis Macrocephalae, Radix Rubiae, Rhizoma Zingiberis, the broken coarse powder of making of Rhizoma Cyperi are put in extractor, add dimethyl sulfoxide moistening again, carry out circumfluence distillation adding after water adds a cover 36 hours, the extracting solution extracted being added active carbon adopts centrifuge to carry out solid-liquid separation decolouring removing dimethyl sulfoxide, the starch inside extracting solution is removed, pectin at membrane filtration; Add Polyethylene Glycol again, tween 80 potassium hydroxide, hydroxyethyl-cellulose, ethanol, static 8 hours of germall bp, centrifugalize is at normal temperatures decoloured, and obtains precipitate, and dry powder is for subsequent use;
(4) Flos Lonicerae, Radix Achyranthis Bidentatae, Semen Ziziphi Spinosae, Fructus Mume, Rhizoma Polygonati, Semen Cassiae are cleaned, put into container, add 80% ethanol of 1-10 times amount, at 60-100 DEG C of alcoholization 50-120 minute, then add the water of 6 times amount, 75 DEG C of insulations 100 minutes, concentration and recovery ethanol, obtain mixed liquor, filter mixed liquor obtains filtrate, and the Chinese medicine residue of filtration repeats above extraction step; Merge twice filtrate, with aperture at 1000um, molecular cut off is in the high temperature resistant high rejection rolling NF membrane of 300KDalton, isolate the large particulate matter in filtrate and supernatant, supernatant concentration, at simmer down to 60 DEG C, relative density is the thick paste of 1.10 ~ 1.14 and dry, pulverize powdered, for subsequent use;
(5) Placenta caprae seu ovis, Radix Glycyrrhizae, Colla Corii Asini, Fructus Jujubae will be pulverized with super micron mill, make cell breakage, obtain micronizing powder;
(6) by three branch and leaf, Fructus Trichosanthis, Flos Rosae Rugosae, Semen Astragali Complanati, Rhizoma Acori Graminei, decoct with 3-5 deionized water doubly, repeat decoction 3 times, each 60min, collect decoction liquor, filter, decoction liquor is concentrated, obtains extractum, by extractum vacuum drying, pulverize to obtain powder;
(7) by above-mentioned steps (1), (2), (3), (4), (5), (6) gained mix homogeneously, then add excipient substance, be prepared into corresponding pharmaceutical dosage form.
7. the preparation method of the Chinese medicine composition of a kind of prevention and therapy puerperal fever in puerperal according to claim 6, is characterized in that: prepared by described capsule comprises the following steps:
(1) Radix Astragali, Radix Notoginseng, Radix Angelicae Sinensis, Semen Persicae, Rhizoma Chuanxiong, Herba Leonuri, Fructus Ligustri Lucidi, Rhizoma Dioscoreae, Rhizoma Gymnadeniae, Bulbus Lilii, Herba speranskiae tuberculatae are cleaned, put into container, add 75% ethanol of 3 times amount, drop in microwave extracting apparatus and carry out microwave extracting, extraction power 1000W, extract 3 times, each 30 minutes, combining extraction liquid, concentrated, be added on DiaionHP-10 macroporous adsorptive resins, 75% ethanol elution, collect 5 times amount column volume eluents, decompression recycling ethanol, concentrated and dry, obtain microwave extraction thing, for subsequent use;
(2) by Folium Artemisiae Argyi, Fructus Lycii, Cortex Cinnamomi, Cortex Magnoliae Officinalis, Poria, CO is joined
2in supercritical extraction device, ethanol is as entrainer, and the percent by volume that entrainer accounts for total extractant is 5%, extracting pressure 20-30MPa, temperature 55 DEG C, CO
2flow 3.5ml/g crude drug min, extraction time 160min, obtains supercritical extract, for subsequent use;
(3) Radix Rehmanniae Preparata, Radix Platycodonis, Radix Saposhnikoviae, Herba Houttuyniae, Radix Polygoni Multiflori, the Rhizoma Atractylodis Macrocephalae, Radix Rubiae, Rhizoma Zingiberis, the broken coarse powder of making of Rhizoma Cyperi are put in extractor, add dimethyl sulfoxide moistening again, carry out circumfluence distillation adding after water adds a cover 36 hours, the extracting solution extracted being added active carbon adopts centrifuge to carry out solid-liquid separation decolouring removing dimethyl sulfoxide, the starch inside extracting solution is removed, pectin at membrane filtration; Add Polyethylene Glycol again, tween 80 potassium hydroxide, hydroxyethyl-cellulose, ethanol, static 8 hours of germall bp, centrifugalize is at normal temperatures decoloured, and obtains precipitate, and dry powder is for subsequent use;
(4) Flos Lonicerae, Radix Achyranthis Bidentatae, Semen Ziziphi Spinosae, Fructus Mume, Rhizoma Polygonati, Semen Cassiae are cleaned, put into container, add 80% ethanol of 1-10 times amount, at 60-100 DEG C of alcoholization 50-120 minute, then add the water of 6 times amount, 75 DEG C of insulations 100 minutes, concentration and recovery ethanol, obtain mixed liquor, filter mixed liquor obtains filtrate, and the Chinese medicine residue of filtration repeats above extraction step; Merge twice filtrate, with aperture at 1000um, molecular cut off is in the high temperature resistant high rejection rolling NF membrane of 300KDalton, isolate the large particulate matter in filtrate and supernatant, supernatant concentration, at simmer down to 60 DEG C, relative density is the thick paste of 1.10 ~ 1.14 and dry, pulverize powdered, for subsequent use;
(5) Placenta caprae seu ovis, Radix Glycyrrhizae, Colla Corii Asini, Fructus Jujubae will be pulverized with super micron mill, make cell breakage, obtain micronizing powder;
(6) by three branch and leaf, Fructus Trichosanthis, Flos Rosae Rugosae, Semen Astragali Complanati, Rhizoma Acori Graminei, decoct with 3-5 deionized water doubly, repeat decoction 3 times, each 60min, collect decoction liquor, filter, decoction liquor is concentrated, obtains extractum, by extractum vacuum drying, pulverize to obtain powder;
(7) by above-mentioned steps (1), (2), (3), (4), (5), (6) gained mix homogeneously, add adhesive again, carry out soft material granulation, granule is dried, add capsule adjuvant, after be distributed into capsule and be finished product, every capsules powder charge is about 10mg.
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CN105853891A (en) * | 2016-06-03 | 2016-08-17 | 河南中医学院 | Traditional Chinese medicine food therapy powder for preventing and treating puerperal diseases and promoting milk secretion |
CN106109830A (en) * | 2016-08-16 | 2016-11-16 | 惠安县科联农业科技有限公司 | A kind of prevention and the Chinese medicine composition for the treatment of puerperal fever |
CN107692235A (en) * | 2017-11-16 | 2018-02-16 | 安徽省阜阳鸿易得食品有限公司 | A kind of female brown sugar that can alleviate dysmenorrhoea |
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CN104666951A (en) * | 2015-02-02 | 2015-06-03 | 祝相科 | Traditional Chinese medicine composition for treating parturient paresis puerperal fever |
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CN104666951A (en) * | 2015-02-02 | 2015-06-03 | 祝相科 | Traditional Chinese medicine composition for treating parturient paresis puerperal fever |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
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CN105853891A (en) * | 2016-06-03 | 2016-08-17 | 河南中医学院 | Traditional Chinese medicine food therapy powder for preventing and treating puerperal diseases and promoting milk secretion |
CN106109830A (en) * | 2016-08-16 | 2016-11-16 | 惠安县科联农业科技有限公司 | A kind of prevention and the Chinese medicine composition for the treatment of puerperal fever |
CN107692235A (en) * | 2017-11-16 | 2018-02-16 | 安徽省阜阳鸿易得食品有限公司 | A kind of female brown sugar that can alleviate dysmenorrhoea |
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