CN102988733A - Traditional Chinese medicine composition for treating postpartum hypogalactia and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating postpartum hypogalactia and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for treating postpartum hypogalactia and a preparation method thereof. The traditional Chinese medicine composition comprises 20-40 parts of angelica sinensis, 25-45 parts of cowherb seed, 20-40 parts of tetrapanax papyriferus, 15-35 parts of fructus liquidambaris, 15-35 parts of rehmannia glutinosa, 15-35 parts of codonopsis pilosula, 5-15 parts of radix ophiopogonis, 5-15 parts of platycodon grandiflorum, 5-15 parts of pericarpium citri reticulatae, 5-15 parts of rhizoma dioscoreae, 5-15 parts of radix trichosanthis, 4-12 parts of radix bupleuri and 3-9 parts of liquorice. The traditional Chinese medicine composition can be prepared to be any clinically available medicament preparation according to the traditional Chinese medicine conventional preparation method, has the efficacies of activating blood to promote menstruation, relieve swelling and pain, hastening child delivery and promoting lactation, has an accurate and reliable curative effect on the treatment of postpartum hypogalactia through the demonstration of the clinical curative effect, can be used for treating both manifestation and root cause of disease, is safe in clinical application, and does not have any toxic and side effect.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, relate in particular to a kind of Chinese medicine composition for the treatment of puerperal hypogalactia and preparation method thereof, belong to the treatment by Chinese herbs field of puerperal hypogalactia.
Background technology
The puerpera when suckling milk very less or completely without, enough even can the feeding infant person, be called puerperal hypogalactia.Chinese medicine claims " galactozemia, hypogalactia ".Degree and the situation of hypogalactia are different: lack during the beginning suckling that has, and slightly many but still inadequate later on; Have completely without milk, can not feed breast fully; The normal suckling that has, after unexpected high heat or seven emotions were crossed extremely, milk was suddenly few, is not enough to feeding infant.Galactopoiesis and wet nurse's spirit, emotion, nutriture, rest and work have relation.Any spiritual stimulation all can reduce galactopoiesis as worried, terrified, worried, sad.Hypogalactia may be relatively poor by development of breast, and the too much or emotion of postpartum hemorrhage is not good enough etc., and factor causes that infection, diarrhoea, loose stool etc. also can make hypogalactia, or because of milk can not Channel Group due to.The former doctor trained in Western medicine be there is no special treatment method, can use the oxytocin intramuscular injection to the latter, flow out to impel milk; Or with methods such as breast pumps.
The traditional Chinese medical science thinks that primary disease has dividing of deficiency and excess.Void person mostly is deficient qi and blood, due to the deficiency of milk source, generally take soft breast and without distending pain as dialectical main points.Reality person is then because of depression of liver-QI, or qi stagnation hemagglutination, due to the galactozemia, and general or pain hard with mammary swelling, or companion's fever of the body is dialectical main points.Clinical need to distinguish deficiency and excess, can not singly have or not distending pain one disease fixed with breast in conjunction with the General Symptoms complete observation.The principle for the treatment of of hypogalactia, empty person should mend and row, real person should dredge and logical it.
Milk source what internal organs, vim and vigour, punching are appointed, " tire produces heart method " cloud: " puerpera's punching appoint blood is prosperous, the prosperous then breast of taste gas foot ".Xue Li vegetarian cloud: " the blood person, the clearing heat in QI system of water paddy also and is transferred the five internal organs, and the old six internal organs of wine then turn to essence the man; Be milk the married woman, be the sea of blood down ", sufficient and taste vim and vigour are strong that substantial connection arranged for the milk that the puerpera be described.Milk is given birth to by QI and bloodization, relies irritability catharsis and adjusting, so hypogalactia is many because of due to deficient qi and blood, the stagnation of QI due to depression of the liver, also has to stop up to stagnate because of mental disorder to cause galactozemia person.Hypogalactia head distinguishes deficiency and excess
At present, the Chinese patent medicine that is used for the treatment of puerperal hypogalactia all in various degree exist slow, the defective such as curative effect is remarkable not that takes effect, have much room for improvement.
Summary of the invention
Technical problem to be solved by this invention be overcome the medicine of existing treatment puerperal hypogalactia existing take effect slow, curative effect not significantly, the defective such as toxic and side effects is large, the Chinese medicine composition of the treatment puerperal hypogalactia that provide a kind of instant effect, determined curative effect, has no side effect;
Another technical problem to be solved by this invention provides a kind of method for preparing above-mentioned Chinese medicine composition.
Above-mentioned technical problem to be solved by this invention is achieved through the following technical solutions:
A kind of Chinese medicine composition for the treatment of puerperal hypogalactia comprises that each component of following weight portion forms:
Radix Angelicae Sinensis 20-40 part, Semen Vaccariae 25-45 part, Medulla Tetrapanacis 20-40 part, Fructus Liquidambaris 15-35 part, Radix Rehmanniae Preparata 15-35 part, Radix Codonopsis 15-35 part, Radix Ophiopogonis 5-15 part, Radix Platycodonis 5-15 part, Pericarpium Citri Reticulatae 5-15 part, Rhizoma Dioscoreae 5-15 part, Radix Trichosanthis 5-15 part, Radix Bupleuri 4-12 part, Radix Glycyrrhizae 3-9 part;
Preferably, the weight portion of each component is: Radix Angelicae Sinensis 25-35 part, Semen Vaccariae 30-40 part, Medulla Tetrapanacis 30-40 part, Fructus Liquidambaris 15-30 part, Radix Rehmanniae Preparata 15-30 part, Radix Codonopsis 15-30 part, Radix Ophiopogonis 8-12 part, Radix Platycodonis 8-12 part, Pericarpium Citri Reticulatae 8-12 part, Rhizoma Dioscoreae 8-12 part, Radix Trichosanthis 8-12 part, Radix Bupleuri 6-9 part, Radix Glycyrrhizae 4-7 part;
Preferred, the weight portion of each component is: 30 parts of Radix Angelicae Sinensis, 35 parts of Semen Vaccariae, 35 parts of Medulla Tetrapanaciss, 25 parts of Fructus Liquidambaris, 20 parts in Radix Rehmanniae Preparata, 20 parts of Radix Codonopsis, 10 parts of Radix Ophiopogonis, 10 parts of Radix Platycodoniss, 10 parts of Pericarpium Citri Reticulataes, 10 parts of Rhizoma Dioscoreaes, 10 parts of Radix Trichosanthis, 7 parts of Radix Bupleuri, 5 parts in Radix Glycyrrhizae.
Radix Angelicae Sinensis: Radix Angelicae Sinensis sweet in the mouth and weighing, so specially can enrich blood, its gas is light and hot, thus again can promoting the circulation of blood, invigorating middle warmer has, in the row benefit is arranged, and is the key medicine in the blood.Thereby it can be enriched blood, and can invigorate blood circulation again, both can stimulate the menstrual flow, again can be active.
Semen Vaccariae: Semen Vaccariae another name Wang Buliu, Vaccaria segetalis.Dry seed for pinkwort Vaccaria segetalis Vaccariasegetalis (neck) Garcker has promoting blood circulation to restore menstrual flow, and reducing swelling and alleviating pain expedites the emergence of the function of stimulating milk secretion.Cure mainly menoxenia, agalactosis, difficult labour, the diseases such as carbuncle furunculosis.
Medulla Tetrapanacis: Medulla Tetrapanacis is the stem pith of Araliaceae rice-paper plant, attaches to the lung and stomach meridians, clear snobbish water; Lactogenesis is used for the puckery pain of stranguria; Dysuria; Edema; Jaundice; Damp-warm diseases; Oliguria with reddish urine; Puerperal, breast was few; Amenorrhea; Leukorrhagia.
Radix Rehmanniae Preparata: Radix Rehmanniae Preparata be scrophulariaceae rehmannia glutinosa plant (formal name used at school: tuber Rehmannia glutinosa), have another name called Radix Rehmanniae Preparata or throw oneself on the ground, concoct through processing and form.Usually shine through repeatedly steaming take wine, Fructus Amomi, Pericarpium Citri Reticulatae as adjuvant, glossy to inside and outside darkish complexion, the quality softness is sticky.Section usefulness, or parch to black is used.Radix Rehmanniae Preparata has another name called Radix Rehmanniae Preparata or throws oneself on the ground, and belongs to goatweed, is a kind of first-class Chinese crude drug, has the YIN nourishing of enriching blood effect, can be used for blood deficiency and yellow complexion, dizzy, palpitation and insomnia, menoxenia, the diseases such as metrorrhagia also can be used for hectic fever hectic fever due to YIN-deficiency, the night sweat of deficiency of kidney yin, the disease such as pass out semen, quench one's thirst.
Fructus Liquidambaris: be the dry mature fruit of Hamamelidaceae Plants Chinese sweet gum.Gather behind the fruit maturation winter, removes impurity, drying.Meridian distribution of property and flavor: hardship, flat.Return liver, kidney channel.Function cures mainly: dispelling, collateral-activating, diuretic stimulates the menstrual flow.Be used for arthralgia, numbness contracture, edema distension, the few amenorrhea of breast.
Radix Trichosanthis: be the root of cucurbitaceous plant Chinese juniper beach wormwood, be clearing away heat-fire class medicine, its concrete effect is clearing away heat-fire, promoting the production of body fluid to quench thirst, evacuation of pus detumescence.Cure mainly: control calentura thirsty, quench one's thirst, jaundice, dryness of the lung hemoptysis, carbuncle, hemorrhoid flaccidity.
Chinese medicine composition of the present invention is based on the inventor to the pathogenetic research of the deep layer of puerperal hypogalactia and Therapeutic Principle thereof, simultaneously according to inventor for many years clinical experience and pharmaceutical research achievement, filter out the crude drug of QI replenishing and blood harmonizing, YIN nourishing and the production of body fluid promoting, dredging collateral for promoting lactation, form according to certain weight proportion prescription.
Has better therapeutic efficiency for puerperal hypogalactia when further adding in the present invention the raw material of following weight portion in the drug composition: Semen Abutili 8-20 part, Herba Melastomatis Candii 8-20 part, Fructus Caricae 8-20 part, Fructus Atriplicis Sibiricae 6-15 part, fly upward 5-15 part, Herba euphorbiae prostratae 5-15 part, Rhizoma Imperatae 4-12 part, Radix Asparagi 4-12 part; Preferably, the weight portion of each crude drug is: 15 parts of Semen Abutilis, 15 parts of Herba Melastomatis Candiis, 15 parts of Fructus Caricae, 12 parts of Fructus Atriplicis Sibiricaees, fly upward 10 parts, 8 parts of Herba euphorbiae prostrataes, 8 parts of Rhizoma Imperataes, 6 parts of Radix Asparagi.
Radix Asparagi: liliaceous plant has another name called Radix Asparagi.Cold in nature, sweet in the mouth, little hardship.Has replenishing YIN and removing heat, the effect of lung moistening nourishing kidney.Be used for controlling fever due to yin deficiency, cough haematemesis, lung abscess, laryngopharynx swelling and pain, quench one's thirst, the disease such as constipation.
Semen Abutili: have another name called certain herbaceous plants with big flowers, certain herbaceous plants with big flowers colza.Mature seed for Malvaceae annual herb plant Semen Abutili.All produce all over China.Gather during seed maturity summer and autumn.Dry, give birth to usefulness, smash to pieces and be used as medicine.Sweet cold sliding sharp, can relieving stranguria by diuresis, again can stimulating milk secretion, intestine moistening.
Herba Melastomatis Candii: be the herb of Melastomateae plants Herba Melastomatis Candii.Excavate Herb autumn, clean, chopping is dried.Sour in the mouth; Puckery; Cool in nature.Return spleen; Stomach; Lung; Liver Channel.Function cures mainly: removing food stagnancy dampness removing, promoting blood circulation and hemostasis; Heat-clearing and toxic substances removing.Staple food is long-pending; Let out dysentery; Hepatitis; The treating swelling and pain by traumatic injury traumatic hemorrhage; Epistaxis; Hemoptysis; Spit blood; Have blood in stool; Menorrhagia; Metrorrhagia; Puerperal abdonimal pain; Leucorrhea; Under the milk ring; The blood examination vasculitis; The intestinal carbuncle; Skin ulcer is swollen; Venom.
Fructus Atriplicis Sibiricae: the mature fruit of or herbaceos perennial Fructus Tribuli Tribulus ter-restris L. annual for zygophyllaceae.All produce in the most of China area, but more with North of Yangtze River.Bitter, hot, flat, enter Liver Channel.Function effect: suppressing the hyperactive liver resolving depression, dispelling pathogenic wind for improving eyesight.Be used for the dizziness due to hyperactivity of liver-YANG headache, hypochondriac pain due to stagnation of liverQI, headache due to pathogenic wind-heat, conjunctival congestion and swelling pain, the diseases such as skin pruritus.
Ramulus et Folium Bauhiniae Faberi: for Euphorbiaceae euphorbia Ramulus et Folium Bauhiniae Faberi Euphorbia hirta L., with all herbal medicine.Summer, autumn gather, and clean, dry; The little hardship of property, little acid, cold.Function cures mainly: heat-clearing and toxic substances removing, dampness removing is antipruritic.Be used for bacillary dysentery, amebic dysentery, enteritis, intestinal infusorian, dyspepsia, bronchitis, pyelonephritis; Eczema, dermatitis, skin pruritus are controlled in external.
Herba euphorbiae prostratae: begin to be stated from " Hainan flora ", be the herb of euphorbia plant Herba euphorbiae prostratae, the Latin plant name: Euphorbia prostrata Ait..Lightly seasoned; Cool in nature; Enter Liver Channel; Function cures mainly: clearing away heat-damp and promoting diuresis; Removing pathogenic heat from blood and toxic substance from the body; Lactogenic.Main dysentery; Have loose bowels; Diphtheria; Milk is rare; Bleeding from the gum; Have blood in stool; Nebulousurine; Hematuria; Herpes zoster; The carbuncle furuncle; Eczema.
Rhizoma Imperatae: the dry rhizome of grass Herba Imperatae Imperata cylindrical (L.) Beauv.var.major (Nees) C.E.Hubb..Another name: Rhizoma Imperatae, manage, eat root, blue root.Cure mainly: cooling blood for hemostasis, heat-clearing and toxic substances removing.Be used for to spit blood, hematuria, pyretic stranguria, edema, jaundice, dysuria, calentura excessive thirst, the gastric heat sound of vomiting of vomitting is coughed.
Fructus Caricae: claim again Fructus Chaenomelis, Caricaceae Fructus Caricae platymiscium Fructus Caricae Carica papaya L. is with fruit medicine.Invigorating the stomach and promoting digestion, nourishing lactogenic, channels sootheing and network vessel quickening.Be used for weakness of the spleen and stomach, inappetence, hypogalactia, Fengshi Guanjie pain, numb limbs and tense tendons, Stomach duodenum ulcer pain.
Each medicine compatibility is played promoting blood circulation to restore menstrual flow together altogether among the side of the present invention, reducing swelling and alleviating pain expedites the emergence of the effect of stimulating milk secretion, and Chinese medicine composition of the present invention is for the puerperal hypogalactia treating both the principal and secondary aspects of a disease, clinical observation on the therapeutic effect confirms that Chinese medicine composition of the present invention is reliable, true for the puerperal hypogalactia determined curative effect.Chinese medicine composition of the present invention is nontoxic, and is safe and reliable, has no adverse reaction after taking, clinical use safety.
The crude drug of respectively distinguishing the flavor of that the present invention is used can be bought at pharmacy and obtain.
Medicine activity component of the present invention can add various adjuvants required when preparing different dosage form, such as disintegrating agent, lubricant, adhesive etc., method of Chinese medicinal with routine is prepared into any suitable clinical preparation, such as oral formulations or external preparation, described oral formulations can be pill, powder, granule, capsule, tablet, oral liquid, drop pill etc.; Used external preparation can unguentum, washing liquid, liniment etc.
A kind of preparation method of Chinese medicine composition of the present invention: after each crude drug of the present invention taken by weighing by described weight portion proportioning, pulverize, sieve (for example can be the 600-1000 mesh sieve), and get final product.Certainly, after also each crude drug can being pulverized, add required adjuvant or the excipient of preparations shaping, be prepared into capsule, tablet or pill according to conventional method.
The another kind of preparation method of Chinese medicine composition of the present invention: take by weighing each crude drug by described weight portion; Each crude drug water is decocted, merge decoction liquor, filter, filtrate is condensed into clear paste, adds adjuvant or the excipient of preparations shaping, preparations shaping, and get final product.
The usage of Chinese medicine composition of the present invention and consumption: dosage of the present invention depends on the factors such as concrete dosage form, patient's age, health status.As guidance: usage and dosage: capsule, each capsule content 0.6 gram crude drug, each oral 1 to 3, three times on the one, 7 days is a course for the treatment of.
The specific embodiment
Further describe the present invention below in conjunction with specific embodiment; these embodiment only are exemplary; what those skilled in the art should understand that is; can make amendment or replace the details of technical solution of the present invention and form lower without departing from the spirit and scope of the present invention, but these modifications and replacing all fall within the scope of protection of the present invention.
The preparation of embodiment 1 capsule
Take by weighing each crude drug (unit: g): Radix Angelicae Sinensis 20, Semen Vaccariae 25, Medulla Tetrapanacis 20, Fructus Liquidambaris 15, Radix Rehmanniae Preparata 15, Radix Codonopsis 15, Radix Ophiopogonis 5, Radix Platycodonis 5, Pericarpium Citri Reticulatae 5, Rhizoma Dioscoreae 5, Radix Trichosanthis 5, Radix Bupleuri 4, Radix Glycyrrhizae 3 by following weight; Above-mentioned each crude drug is decocted with water secondary, add 4 times of weight of water for the first time, decocted 2 hours, add 5 times of weight of water for the second time, decocted 1.5 hours; Decoction liquor is merged, filter, filtrate is concentrated into the clear paste that relative density is 1.17-1.19 (60 ℃); Merge clear paste twice, add appropriate amount of starch, mixing, dry, pulverize, add the appropriate amount of ethanol granulation, drying, granulate, filled capsules, and get final product.
The preparation of embodiment 2 capsules
Take by weighing each crude drug (unit: g): Radix Angelicae Sinensis 40, Semen Vaccariae 45, Medulla Tetrapanacis 40, Fructus Liquidambaris 35, Radix Rehmanniae Preparata 35, Radix Codonopsis 35, Radix Ophiopogonis 15, Radix Platycodonis 15, Pericarpium Citri Reticulatae 15, Rhizoma Dioscoreae 15, Radix Trichosanthis 15, Radix Bupleuri 12, Radix Glycyrrhizae 9 by following weight; Above-mentioned each crude drug is decocted with water secondary, add 6 times of weight of water for the first time, decocted 2 hours, add 4 times of weight of water for the second time, decocted 1.5 hours; Decoction liquor is merged, filter, filtrate is concentrated into the clear paste that relative density is 1.17-1.19 (60 ℃); Merge clear paste twice, add appropriate amount of starch, mixing, dry, pulverize, add the appropriate amount of ethanol granulation, drying, granulate, filled capsules, and get final product.
The preparation of embodiment 3 capsules
Take by weighing each crude drug (unit: g): Radix Angelicae Sinensis 30, Semen Vaccariae 35, Medulla Tetrapanacis 35, Fructus Liquidambaris 25, Radix Rehmanniae Preparata 20, Radix Codonopsis 20, Radix Ophiopogonis 10, Radix Platycodonis 10, Pericarpium Citri Reticulatae 10, Rhizoma Dioscoreae 10, Radix Trichosanthis 10, Radix Bupleuri 7, Radix Glycyrrhizae 5 by following weight; Above-mentioned each crude drug is decocted with water secondary, add 4 times of weight of water for the first time, decocted 2 hours, add 5 times of weight of water for the second time, decocted 1.5 hours; Decoction liquor is merged, filter, filtrate is concentrated into the clear paste that relative density is 1.30-1.35 (55 ℃); Merge clear paste twice, add appropriate amount of starch, mixing, dry, pulverize, add the appropriate amount of ethanol granulation, drying, granulate, filled capsules, and get final product.
The preparation of embodiment 4 capsules
By following weight take by weighing each crude drug (unit: g): Radix Angelicae Sinensis 20, Semen Vaccariae 25, Medulla Tetrapanacis 20, Fructus Liquidambaris 15, Radix Rehmanniae Preparata 15, Radix Codonopsis 15, Radix Ophiopogonis 5, Radix Platycodonis 5, Pericarpium Citri Reticulatae 5, Rhizoma Dioscoreae 5, Radix Trichosanthis 5, Radix Bupleuri 4, Radix Glycyrrhizae 3, Semen Abutili 8, Herba Melastomatis Candii 8, Fructus Caricae 8, Fructus Atriplicis Sibiricae 6, fly upward 5, Herba euphorbiae prostratae 5, Rhizoma Imperatae 4, Radix Asparagi 4; Above-mentioned each crude drug is decocted with water secondary, add 4 times of weight of water for the first time, decocted 2 hours, add 5 times of weight of water for the second time, decocted 1.5 hours; Decoction liquor is merged, filter, filtrate is concentrated into the clear paste that relative density is 1.17-1.19 (60 ℃); Merge clear paste twice, add appropriate amount of starch, mixing, dry, pulverize, add the appropriate amount of ethanol granulation, drying, granulate, filled capsules, and get final product.
The preparation of embodiment 5 capsules
By following weight take by weighing each crude drug (unit: g): Radix Angelicae Sinensis 40, Semen Vaccariae 45, Medulla Tetrapanacis 40, Fructus Liquidambaris 35, Radix Rehmanniae Preparata 35, Radix Codonopsis 35, Radix Ophiopogonis 15, Radix Platycodonis 15, Pericarpium Citri Reticulatae 15, Rhizoma Dioscoreae 15, Radix Trichosanthis 15, Radix Bupleuri 12, Radix Glycyrrhizae 9, Semen Abutili 20, Herba Melastomatis Candii 20, Fructus Caricae 20, Fructus Atriplicis Sibiricae 15, fly upward 15, Herba euphorbiae prostratae 15, Rhizoma Imperatae 12, Radix Asparagi 12; Above-mentioned each crude drug is decocted with water secondary, add 6 times of weight of water for the first time, decocted 2 hours, add 4 times of weight of water for the second time, decocted 1.5 hours; Decoction liquor is merged, filter, filtrate is concentrated into the clear paste that relative density is 1.17-1.19 (60 ℃); Merge clear paste twice, add appropriate amount of starch, mixing, dry, pulverize, add the appropriate amount of ethanol granulation, drying, granulate, filled capsules, and get final product.
The preparation of embodiment 6 capsules
By following weight take by weighing each crude drug (unit: g): Radix Angelicae Sinensis 30, Semen Vaccariae 35, Medulla Tetrapanacis 35, Fructus Liquidambaris 25, Radix Rehmanniae Preparata 20, Radix Codonopsis 20, Radix Ophiopogonis 10, Radix Platycodonis 10, Pericarpium Citri Reticulatae 10, Rhizoma Dioscoreae 10, Radix Trichosanthis 10, Radix Bupleuri 7, Radix Glycyrrhizae 5, Semen Abutili 15, Herba Melastomatis Candii 15, Fructus Caricae 15, Fructus Atriplicis Sibiricae 12, fly upward 10, Herba euphorbiae prostratae 8, Rhizoma Imperatae 8, Radix Asparagi 6; Above-mentioned each crude drug is decocted with water secondary, add 4 times of weight of water for the first time, decocted 2 hours, add 5 times of weight of water for the second time, decocted 1.5 hours; Decoction liquor is merged, filter, filtrate is concentrated into the clear paste that relative density is 1.30-1.35 (55 ℃); Merge clear paste twice, add appropriate amount of starch, mixing, dry, pulverize, add the appropriate amount of ethanol granulation, drying, granulate, filled capsules, and get final product.
The clinical observation on the therapeutic effect test of test example 1 traditional Chinese medicine composition for treating puerperal hypogalactia of the present invention
One, physical data: 148 routine patients all meet the clinical criteria of puerperal hypogalactia, 22 years old～36 years old age, average 27 years old.The patient is divided into two groups at random, every group of 74 examples; No significant difference on two groups of ages, the course of disease and coincident with severity degree of conditions.
Two, trial drug
The medicine that embodiment of the invention 1-6 is prepared.
Three, Therapeutic Method
148 routine patients are divided into 2 groups at random, that is: test 2 groups of 1 group and tests, every group of each 74 example are tested 1 group and are adopted the prepared capsule treatment of embodiment 1-3, test 2 groups and adopt the prepared capsules treatment of embodiment 4-6; Oral, one time 3 (0.6g crude drug/grain), 3 times on the one, 7 days is a course for the treatment of, treats altogether 2 courses for the treatment of; Period in a medicine is withdrawn other related drugs and other treatment.
Four, efficacy assessment standard
Efficacy assessment standard and foundation: criterion of therapeutical effect: treat forward and backward 1 week, 2 weeks, 3 weeks, patient's sings and symptoms is carried out objective scoring.Clinical symptoms and sign are undertaken by 4 grades of point systems, 0=without, 1=is slight, 2=moderate, 3=severe.Recovery from illness reduces＞95% for integrated value, and produce effects is integrated value＞60%, transfers well integrated value minimizing 20%～60% to, and invalid is that integrated value reduces＜20%.Integrated value: total mark * 100% before (integration after integration before the treatment-treatment)/treatment.
Five, clinical observation result
Clinical observation result sees Table 1.
The clinical observation on the therapeutic effect result of the test of table 1 traditional Chinese medicine composition for treating puerperal hypogalactia of the present invention
Clinical observation on the therapeutic effect is the result show, Chinese medicine composition of the present invention has significant curative effect for the puerperal hypogalactia patient; Safety observe to be found, does not observe any clinical adverse, show Chinese medicine composition clinical practice of the present invention safely, have no side effect.
Claims (7)
1. Chinese medicine composition for the treatment of puerperal hypogalactia comprises that each component of following weight portion forms: Radix Angelicae Sinensis 20-40 part, Semen Vaccariae 25-45 part, Medulla Tetrapanacis 20-40 part, Fructus Liquidambaris 15-35 part, Radix Rehmanniae Preparata 15-35 part, Radix Codonopsis 15-35 part, Radix Ophiopogonis 5-15 part, Radix Platycodonis 5-15 part, Pericarpium Citri Reticulatae 5-15 part, Rhizoma Dioscoreae 5-15 part, Radix Trichosanthis 5-15 part, Radix Bupleuri 4-12 part, Radix Glycyrrhizae 3-9 part.
2. according to Chinese medicine composition claimed in claim 1, it is characterized in that the weight portion of each component is: Radix Angelicae Sinensis 25-35 part, Semen Vaccariae 30-40 part, Medulla Tetrapanacis 30-40 part, Fructus Liquidambaris 15-30 part, Radix Rehmanniae Preparata 15-30 part, Radix Codonopsis 15-30 part, Radix Ophiopogonis 8-12 part, Radix Platycodonis 8-12 part, Pericarpium Citri Reticulatae 8-12 part, Rhizoma Dioscoreae 8-12 part, Radix Trichosanthis 8-12 part, Radix Bupleuri 6-9 part, Radix Glycyrrhizae 4-7 part.
3. according to Chinese medicine composition claimed in claim 2, it is characterized in that the weight portion of each component is: 30 parts of Radix Angelicae Sinensis, 35 parts of Semen Vaccariae, 35 parts of Medulla Tetrapanaciss, 25 parts of Fructus Liquidambaris, 20 parts in Radix Rehmanniae Preparata, 20 parts of Radix Codonopsis, 10 parts of Radix Ophiopogonis, 10 parts of Radix Platycodoniss, 10 parts of Pericarpium Citri Reticulataes, 10 parts of Rhizoma Dioscoreaes, 10 parts of Radix Trichosanthis, 7 parts of Radix Bupleuri, 5 parts in Radix Glycyrrhizae.
4. Chinese medicine composition for the treatment of puerperal hypogalactia comprises that each component of following weight portion forms: Radix Angelicae Sinensis 20-40 part, Semen Vaccariae 25-45 part, Medulla Tetrapanacis 20-40 part, Fructus Liquidambaris 15-35 part, Radix Rehmanniae Preparata 15-35 part, Radix Codonopsis 15-35 part, Radix Ophiopogonis 5-15 part, Radix Platycodonis 5-15 part, Pericarpium Citri Reticulatae 5-15 part, Rhizoma Dioscoreae 5-15 part, Radix Trichosanthis 5-15 part, Radix Bupleuri 4-12 part, Radix Glycyrrhizae 3-9 part, Semen Abutili 8-20 part, Herba Melastomatis Candii 8-20 part, Fructus Caricae 8-20 part, Fructus Atriplicis Sibiricae 6-15 part, fly upward 5-15 part, Herba euphorbiae prostratae 5-15 part, Rhizoma Imperatae 4-12 part, Radix Asparagi 4-12 part.
5. according to Chinese medicine composition claimed in claim 4, it is characterized in that the weight portion of each component is: 30 parts of Radix Angelicae Sinensis, 35 parts of Semen Vaccariae, 35 parts of Medulla Tetrapanaciss, 25 parts of Fructus Liquidambaris, 20 parts in Radix Rehmanniae Preparata, 20 parts of Radix Codonopsis, 10 parts of Radix Ophiopogonis, 10 parts of Radix Platycodoniss, 10 parts of Pericarpium Citri Reticulataes, 10 parts of Rhizoma Dioscoreaes, 10 parts of Radix Trichosanthis, 7 parts of Radix Bupleuri, 5 parts in Radix Glycyrrhizae, 15 parts of Semen Abutilis, 15 parts of Herba Melastomatis Candiis, 15 parts of Fructus Caricae, 12 parts of Fructus Atriplicis Sibiricaees, fly upward 10 parts, 8 parts of Herba euphorbiae prostrataes, 8 parts of Rhizoma Imperataes, 6 parts of Radix Asparagi.
6. method for preparing any one described Chinese medicine composition of claim 1-5 may further comprise the steps:
(1), takes by weighing each crude drug by described weight proportion;
(2), each crude drug water is decocted, merge decoction liquor, filter, filtrate is condensed into clear paste, adds adjuvant or the excipient of preparations shaping, preparations shaping, and get final product.
7. any one described Chinese medicine composition of claim 1-6 is preparing the purposes for the treatment of in the puerperal hypogalactia medicine.
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| CN106266527A (en) * | 2015-05-13 | 2017-01-04 | 蒋蓉 | A kind of Chinese patent medicine treating puerperal hypogalactia |
| CN107050284A (en) * | 2016-11-11 | 2017-08-18 | 东莞市百替生物科技有限公司 | A kind of Chinese medicine composition and preparation method for nursing one's health hypogalactia after delivery |
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| CN107050284A (en) * | 2016-11-11 | 2017-08-18 | 东莞市百替生物科技有限公司 | A kind of Chinese medicine composition and preparation method for nursing one's health hypogalactia after delivery |
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Application publication date: 20130327 |