CN105770409B - Have effects that promote the Chinese medicine composition and its preparation method and application of lactation - Google Patents
Have effects that promote the Chinese medicine composition and its preparation method and application of lactation Download PDFInfo
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Abstract
The present invention discloses a kind of Chinese medicine composition and its preparation method and application with rush lactation.Described to have effects that promote the Chinese medicine composition of lactation, effective component is prepared by the raw material of following parts by weight: 10-20 parts of Radix Codonopsis, 10-20 parts of Radix Astragali, 10-20 parts of rhizoma polygonati, 5-15 parts of Radix Angelicae Sinensis, Radix Ophiopogonis 5-15 part, 5-15 parts of campanulaceae.Described to have effects that promote the Chinese medicine composition of lactation, raw material is formed using pure Chinese medicines materials such as Radix Codonopsis, Radix Astragali, Radix Angelicae Sinensis, rhizoma polygonati, Radix Ophiopogonis, campanulaceaes according to the tcm theory compatibility of monarch, safe and nontoxic, medicinal peace is mended without dry, with the benefits of air making-up and spleen enlivening, blood-nourishing promotes lactation.Verified through effect experiment it is bright, it is of the present invention have effects that promote lactation Chinese medicine composition have facilitation to the lactation function of rat, have effects that similar to or better than existing goods rush lactations.
Description
Technical field
The present invention relates to field of Chinese medicinal composition, more particularly to it is a kind of have effects that promote the Chinese medicine composition of lactation and its
Preparation method and application.
Background technique
Before for many years, breast milk just has proven to be neonatal preferred healthy food, with breast-fed babies
It is more healthier than fed infants such as milk and clever.It is counted according to State Family Planning Commission, newborn's breast milk in 4 months is fed
Feeding rate reaches 92.88%, that is to say, that annual a minimum of 18,000,000 puerpera carries out breast-feeding to baby.
And count according to data center, State Family Planning Commission: 39.8% puerpera has the few symptom of serious agalasisa, cream,
There is mammary gland blockage complicated with acute mazoitis during nursing in 46.3% puerpera, and when 62.8% puerpera's delaactation will be subjected to difference
The swollen breasts of degree, the quantity that the above crowd adds up have been over 18,000,000 people.
Puerpera's postpartum cream is common less, and there are two types of situations: first is that mammary gland is obstructed, theory of traditional Chinese medical science thinks true card；Second is that milk
It is few, belong to asthenic symptoms.Asthenic symptoms show as having a delicate constitution, lusterless complexion, shortness of breath and palpitation, unconsciously sweat and tire, and mostly because weakness of the spleen and the stomach, qi and blood is not
Caused by foot or stagnation of liver qi, most of agalasisas, few newborn women are asthenic symptoms.
Summary of the invention
Based on this, have effects that promote the Chinese medicine composition and preparation method thereof of lactation the purpose of the present invention is to provide a kind of
And application.
To achieve the above object, the present invention takes following technical scheme:
A kind of to have effects that promote the Chinese medicine composition of lactation, effective component is prepared by the raw material of following parts by weight:
10-20 parts of Radix Codonopsis, 10-20 parts of Radix Astragali, 10-20 parts of rhizoma polygonati, 5-15 parts of Radix Angelicae Sinensis, Radix Ophiopogonis 5-15 part, 5-15 parts of campanulaceae.
Its effective component is prepared by the raw material of following parts by weight in one of the embodiments:
14-16 parts of Radix Codonopsis, 14-16 parts of Radix Astragali, 14-16 parts of rhizoma polygonati, 9-11 parts of Radix Angelicae Sinensis, Radix Ophiopogonis 9-11 part, 9-11 parts of campanulaceae.
Its effective component is prepared by the raw material of following parts by weight in one of the embodiments:
15 parts of Radix Codonopsis, 15 parts of Radix Astragali, 15 parts of rhizoma polygonati, 10 parts of Radix Angelicae Sinensis, 10 parts of Radix Ophiopogonis, 10 parts of campanulaceae.
The present invention also provides the preparation methods of the Chinese medicine composition with rush lactation, include the following steps:
After the Radix Codonopsis of the parts by weight, Radix Astragali, rhizoma polygonati, Radix Angelicae Sinensis, Radix Ophiopogonis, campanulaceae are mixed, extraction, extracting solution are added water to cook
After concentration, pharmaceutically acceptable auxiliary material is added, regular dosage form is made to get the Chinese medicine composition with rush lactation.
The method for adding water to cook extraction is the decocting for being added 6-12 times of raw-material weight in one of the embodiments,
It boils 1-3 times, decocts 1.5-2.5 hours every time.
The method for adding water to cook extraction is the decocting for being added 8-10 times of raw-material weight in one of the embodiments,
It boils 2 times, decocts 1.5-2.5 hours every time.
The present invention also provides the Chinese medicine compositions promote with lactation to have effects that promote the guarantor of lactation in preparation
Application in strong product.
The principle of the invention and advantage are as follows:
It is of the present invention to have effects that promote the Chinese medicine composition of lactation, use pure Chinese medicine for raw material, according to monarch
Tcm theory compatibility forms, and overcomes the deficiency of simple single effect, enhances drug effect, and various aspects regulation is logical to reach blood-nourishing
The effect of newborn: Radix Codonopsis air making-up and spleen enlivening, Radix Astragali tonifying Qi liter mention, and qi and blood is made to turn to milk, are altogether monarch drug in a prescription；Chinese Angelica blood replonishing promoting blood circulation, rhizoma polygonati
Blood-nourishing strengthening the essence keeps milk source inexhaustible, is altogether ministerial drug；Radix Ophiopogonis yin-nourishing benefit stomach is adjutant as a means of source is changed；Campanulaceae promotes lactation network, to make
Medicine.All medicines share, medicinal peace mend without dry, play air making-up and spleen enlivening, the function that blood-nourishing promotes lactation altogether.
Compared with prior art, the invention has the following advantages:
Of the present invention to have effects that promote the Chinese medicine composition of lactation, raw material uses Radix Codonopsis, Radix Astragali, Radix Angelicae Sinensis, rhizoma polygonati, wheat
The pure Chinese medicines material such as winter, campanulaceae forms, safe and nontoxic, medicinal peace according to the tcm theory compatibility of monarch, mends without dry,
With the benefits of air making-up and spleen enlivening, blood-nourishing promotes lactation.It is verified through effect experiment, and the Chinese traditional medicine composition with rush lactation of the present invention
Object has facilitation to the lactation function of rat, has effects that rush lactations similar or better than existing goods.
Specific embodiment
Have effects that promote the Chinese medicine composition of lactation and its preparation side to of the present invention below in conjunction with specific embodiment
Method and application are described further.
Embodiment 1
The present embodiment is a kind of to have effects that promote the Chinese medicine composition of lactation, effective component by following parts by weight raw material system
It is standby to form:
15 parts of Radix Codonopsis, 15 parts of Radix Astragali, 15 parts of rhizoma polygonati, 10 parts of Radix Angelicae Sinensis, 10 parts of Radix Ophiopogonis, 10 parts of campanulaceae.
The preparation method of the above-mentioned Chinese medicine composition promote with lactation, includes the following steps:
After the Radix Codonopsis of the parts by weight, Radix Astragali, rhizoma polygonati, Radix Angelicae Sinensis, Radix Ophiopogonis, campanulaceae are mixed, extraction 2 times is added water to cook, the
It is primary that 10 times of water of raw-material weight are added, it decocts 2.5 hours, second of addition 8 times of water of raw-material weight decocts 1.5 hours, filter
It crosses, extracting solution merges, and is concentrated into the clear cream that relative density is 1.15-1.25 (75-90 DEG C), and it is appropriate (dry that soluble starch is added
Gu object content × 100%), reduced vacuum dry (≤80 DEG C) crushes, and granule is made to be had effects that promote lactation to get described
Chinese medicine composition.
Embodiment 2
The present embodiment is a kind of to have effects that promote the Chinese medicine composition of lactation, effective component by following parts by weight raw material system
It is standby to form:
15 parts of Radix Codonopsis, 15 parts of Radix Astragali, 15 parts of rhizoma polygonati, 10 parts of Radix Angelicae Sinensis, 10 parts of Radix Ophiopogonis, 10 parts of campanulaceae.It is above-mentioned that there is rush lactation
The preparation method of the Chinese medicine composition of effect, includes the following steps:
After the Radix Codonopsis of the parts by weight, Radix Astragali, rhizoma polygonati, Radix Angelicae Sinensis, Radix Ophiopogonis, campanulaceae are mixed, extraction 2 times is added water to cook, the
The primary water for being added 12 times of raw-material weight, decocts 2.5 hours, and it is small to decoct 1.5 for the water of second of 6 times of raw-material weight of addition
When, filtration, extracting solution merges, and is concentrated into the clear cream that relative density is 1.15-1.25 (75-90 DEG C), it is suitable that soluble starch is added
It measures (dry solids content × 100%), reduced vacuum dry (≤80 DEG C) crushes, and granule, which is made, to get described has rush lactation
The Chinese medicine composition of effect.
Embodiment 3
The present embodiment is a kind of to have effects that promote the Chinese medicine composition of lactation, effective component by following parts by weight raw material system
It is standby to form:
10 parts of Radix Codonopsis, 10 parts of Radix Astragali, 10 parts of rhizoma polygonati, 5 parts of Radix Angelicae Sinensis, 5 parts of Radix Ophiopogonis, 5 parts of campanulaceae.
The preparation method of the above-mentioned Chinese medicine composition promote with lactation, includes the following steps:
After the Radix Codonopsis of the parts by weight, Radix Astragali, rhizoma polygonati, Radix Angelicae Sinensis, Radix Ophiopogonis, campanulaceae are mixed, extraction 1 time is added water to cook, is added
The water for entering 10 times of raw-material weight is decocted 2 hours and is filtered, and it is 1.15-1.25 (75-90 DEG C) that extracting solution, which is concentrated into relative density,
Soluble starch is added in right amount (dry solids content × 100%) in clear cream, and reduced vacuum dry (≤80 DEG C) crushes, and particle is made
Agent has effects that promote the Chinese medicine composition of lactation to get described.
Embodiment 4
The present embodiment is a kind of to have effects that promote the Chinese medicine composition of lactation, effective component by following parts by weight raw material system
It is standby to form:
20 parts of Radix Codonopsis, 20 parts of Radix Astragali, 20 parts of rhizoma polygonati, 15 parts of Radix Angelicae Sinensis, 15 parts of Radix Ophiopogonis, 15 parts of campanulaceae.
The preparation method of the above-mentioned Chinese medicine composition promote with lactation, includes the following steps:
After the Radix Codonopsis of the parts by weight, Radix Astragali, rhizoma polygonati, Radix Angelicae Sinensis, Radix Ophiopogonis, campanulaceae are mixed, extraction 3 times is added water to cook, the
The primary water for being added 12 times of raw-material weight, decocts 2.5 hours, second and third time is separately added into 6 times of raw-material weight of water, decocts
It boils 1.5 hours, filters, extracting solution merges, and is concentrated into the clear cream that relative density is 1.15-1.25 (75-90 DEG C), is added soluble
Appropriate starch (solid object amount × 100%), reduced vacuum dry (≤80 DEG C) crush, and granule, which is made, to get described has rush
The Chinese medicine composition of lactation effect.
Embodiment 5
The present embodiment is the effect experiment of the Chinese medicine composition promote with lactation of the present invention.
Given the test agent: have effects that promote the Chinese medicine composition of lactation described in Examples 1 and 2.
Experimental animal: SD rat, SPF grades, 60 (168.5~245.8g) of female, male 30 (168.5~
245.8g)。
Experimental method:
1, dose design: the clinical taking dose of given the test agent is 37.5g/ days/day, is estimated by 60kg weight, and clinic is answered
It is 0.625g powder/kg weight with dosage, being converted into the experiment of rat with dosage is (the 5 times of clinical agent of 3.125g powder/kg weight
Amount), the dosage of practical rat intake is that A group (has effects that promote the Chinese medicine composition of lactation) 6.2g/ described in intake embodiment 1
Kg, B group (have effects that promote the Chinese medicine composition of lactation) that 6.1g/kg (is respectively equivalent to clinical dosage described in intake embodiment 2
9.9 times and 9.8 times).Positive control medicine selects fish oyster lactogenesis curing capsule, and clinical dosage is 10.8g/ days/day, by 60kg body
Revaluation is calculated, and clinical application dosage is 0.18g/kg weight, and the experiment dosage (5 times of clinical dosages) for being converted into rat is 0.9g/
Kg weight, commercially available capule size are 0.45g/, i.e., the experiment dosage of positive controls rat is 2/kg weight；
2, breed: after rat feeding is suitble to first service to weight, by rat 17:00 in afternoon or so with female: male 2:1 is put
Enter in the cage that mates, observes negative bolt (or vaginal smear) morning next day, find negative bolt (or sperm), it is believed that the mouse has mated.If
It does not mate in 5d, then replaces male mouse.
3, raise: the female mice single cage become pregnant is fed, free diet, until fetus lactation 3 weeks, put to death fetus.
4, breed for second: breeding method is the same as step 2.
5, equal nest and grouping: the fetus birth same day is the 1st day female rat postpartum (d1), selects the nest with a brood of enough 10 fetus
Mouse, fetus of every nest more than 10 are cast out at random, and adjusting every nest newborn mouse quantity is 10.Female rat is randomly divided into negative control
Group, positive controls, given the test agent A group and given the test agent B group.The female rat produced later is selected nest mouse by the same method and is grouped, directly
There are 12 nest newborn mouses to every group；
6, give tested material: the 3rd day female rat postpartum (d 3) starts to give tested material.Negative control group is fed with normal diet；
The fish oyster lactogenesis curing capsule solution of the daily stomach-filling 0.09g/mL of positive controls, 1mL/100g, 1 times/day；Given the test agent A group
Feed of the feeding containing the Chinese medicine composition described in 3.9% embodiment 1 to promote with lactation；The feeding of given the test agent B group contains 3.9%
Have effects that the Chinese medicine composition for promoting lactation promotees the feed of lactation side 2 described in embodiment 2.The time of tested material is given as female rat production
The 3rd day to postpartum the 17th day afterwards, continuously give tested material 15 days.Experiment terminates to be postpartum 21 days (d21).
Result judgement: the newborn mouse weight gain of each group any time point has conspicuousness with negative control group comparing difference, can
It is determined as that the given the test agent promotes lactation function results of animal positive.
Experimental result is as shown in table 1-3:
Table 1 test female rat nursing period weight (N=12)
Note: compared with negative control group, P < 0.05 *；
Weight ratio negative control group of the given the test agent A group in d17 is high, and difference is statistically significant (P < 0.05), remaining group
Not in the weight of each minute compared with negative control group equal no difference of science of statistics.
Table 2 test female rat nursing period food ration (N=12)
Note: compared with negative control group, P < 0.05 *；
Given the test agent A group ingesting during d3~d6 is more than negative control group, and difference is statistically significant (P < 0.05),
Ingest with negative control group compared with equal no difference of science of statistics of remaining group in each minute.
Table 3 test nursing period newborn mouse average weight gain (N=12)
Note: compared with negative control group, P < 0.01 * P < 0.05, * *；
The newborn mouse average weight gain of positive controls has 2 time points to be greater than negative control group, and the newborn mouse of given the test agent A group is flat
6 time points of weight gain are all larger than negative control group, and the newborn mouse average weight gain of given the test agent B group has 2 time points to be greater than feminine gender
Control group.It can be seen that of the present invention have effects that promote the Chinese medicine composition of lactation and fish oyster lactogenesis curing capsule to big
The lactation function of mouse has facilitation, and the Chinese medicine composition with rush lactation of the present invention has similar or is better than
Rush lactation effect of existing goods.
Also know there is that the drug effect for promoting the Chinese medicine composition of lactation is substantially better than reality described in embodiment 1 by 3 data of table
Example 2 is applied, being detected embodiment 1 has effects that the polyoses content for promoting the Chinese medicine composition of lactation higher than embodiment 2, and saponin content
Less than embodiment 2.It is different that the difference of the two extraction process may cause effective component extraction rate, to exist to drug effect certain
It influences, but the two all shows good rush galactogogue action.
The embodiments described above only express several embodiments of the present invention, and the description thereof is more specific and detailed, but simultaneously
Limitations on the scope of the patent of the present invention therefore cannot be interpreted as.It should be pointed out that for those of ordinary skill in the art
For, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to guarantor of the invention
Protect range.Therefore, the scope of protection of the patent of the invention shall be subject to the appended claims.
Claims (7)
1. it is a kind of have effects that promote lactation Chinese medicine composition, which is characterized in that its effective component by following parts by weight raw material
It is prepared:
10-20 parts of Radix Codonopsis, 10-20 parts of Radix Astragali, 10-20 parts of rhizoma polygonati, 5-15 parts of Radix Angelicae Sinensis, Radix Ophiopogonis 5-15 part, 5-15 parts of campanulaceae.
2. according to claim 1 have effects that promote the Chinese medicine composition of lactation, which is characterized in that its effective component is by such as
The raw material of lower parts by weight is prepared:
14-16 parts of Radix Codonopsis, 14-16 parts of Radix Astragali, 14-16 parts of rhizoma polygonati, 9-11 parts of Radix Angelicae Sinensis, Radix Ophiopogonis 9-11 part, 9-11 parts of campanulaceae.
3. according to claim 1 have effects that promote the Chinese medicine composition of lactation, which is characterized in that its effective component is by such as
The raw material of lower parts by weight is prepared:
15 parts of Radix Codonopsis, 15 parts of Radix Astragali, 15 parts of rhizoma polygonati, 10 parts of Radix Angelicae Sinensis, 10 parts of Radix Ophiopogonis, 10 parts of campanulaceae.
4. the preparation method of the described in any item Chinese medicine compositions promote with lactation of claim 1-3, which is characterized in that
Include the following steps:
After the Radix Codonopsis of the parts by weight, Radix Astragali, rhizoma polygonati, Radix Angelicae Sinensis, Radix Ophiopogonis, campanulaceae are mixed, extraction, extracting solution concentration are added water to cook
Afterwards, pharmaceutically acceptable auxiliary material is added, regular dosage form is made to get the Chinese medicine composition with rush lactation.
5. the preparation method of the Chinese medicine composition promote with lactation according to claim 4, which is characterized in that described
The method for adding water to cook extraction is water decoction 1-3 time for being added 6-12 times of raw-material weight, is decocted 1.5-2.5 hours every time.
6. the preparation method of the Chinese medicine composition promote with lactation according to claim 5, which is characterized in that described
The method for adding water to cook extraction is water decoction 2 times for being added 8-10 times of raw-material weight, is decocted 1.5-2.5 hours every time.
7. claim 1-3 is described in any item to have effects that the Chinese medicine composition for promoting lactation has effects that promote lactation in preparation
Application in health care product.
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| CN111494579B (en) * | 2020-04-23 | 2021-08-13 | 四川省中医药科学院中医研究所 | Composition with lactation promoting effect |
| CN112293630A (en) * | 2020-10-30 | 2021-02-02 | 成都致耀医药科技有限公司 | Plant beverage for promoting lactation and preparation method thereof |
| CN112516268A (en) * | 2020-12-02 | 2021-03-19 | 建昌帮药业有限公司 | Traditional Chinese medicine composition for treating postpartum disease and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102988733A (en) * | 2012-11-13 | 2013-03-27 | 黄文珍 | Traditional Chinese medicine composition for treating postpartum hypogalactia and preparation method thereof |
| CN103169925A (en) * | 2013-04-12 | 2013-06-26 | 杨邱月 | Traditional Chinese medicine composition for treating hypogalactia and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102988733A (en) * | 2012-11-13 | 2013-03-27 | 黄文珍 | Traditional Chinese medicine composition for treating postpartum hypogalactia and preparation method thereof |
| CN103169925A (en) * | 2013-04-12 | 2013-06-26 | 杨邱月 | Traditional Chinese medicine composition for treating hypogalactia and preparation method thereof |
Non-Patent Citations (1)
| Title |
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| 傅青主女科二方加减治疗产后缺乳临床疗效观察;廖云霞;《医学信息》;20091231(第12期);2743 |
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