CN101991673B - Application of traditional Chinese medicine composition to promoting milk secretion, and preparation method thereof - Google Patents
Application of traditional Chinese medicine composition to promoting milk secretion, and preparation method thereof Download PDFInfo
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- CN101991673B CN101991673B CN 200910041971 CN200910041971A CN101991673B CN 101991673 B CN101991673 B CN 101991673B CN 200910041971 CN200910041971 CN 200910041971 CN 200910041971 A CN200910041971 A CN 200910041971A CN 101991673 B CN101991673 B CN 101991673B
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Abstract
The invention discloses novel application of a traditional Chinese medicine composition to preparing a Chinese material medical preparation for promoting milk secretion. Because the selected medicine is a traditional Chinese medicine, no toxic and side effects are obtained, and the composition can be prepared into the Chinese material medical preparation to be taken by women suffering from postpartum hypogalactia or few hypogalactia.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition that promotes lactogenic, the invention still further relates to the preparation method of this Chinese medicine composition.
Technical background
Modern medicine thinks that women's lactogenic is a very complex physical process, and except that being subjected to factor affecting such as multiple hormone, also relevant with factors such as mother's nutrition, spirit, psychology, environment, the stimulation of some medicines also produces significant effects to lactogenic in addition.Nutrient substance such as breast milk rich in proteins, fat, sugar; and contain multiple nonspecific immunity materials such as complement, bifidus factor; have the protection baby and support the ability of disturbing infected by microbes; so the breast milk best wholefood breast feeding that is the baby can not only be satisfied baby's nutritional need; but also for baby's resist the disease provides antibody, it is the key factor of children's health existence.But various reasons such as the modern life and health has the puerpera more than 30% not have milk or hypogalactia juice puerperal.Puerperal hypogalactia also is to carry out one of breastfeeding obstacle.
Chinese medicine is thought body fluid blood homology, and milk is the parent QI and bloodization, and diet is the material base that milk generates.The reason of hypogalactia has deficiency and excess two aspects: real person is a functional activity of QI being not smooth, and QI and blood is obstructed, galactozemia, hypogalactia; Void person is the body deficiency of qi and blood, and the biochemical deficiency of essence of water and grain or exhaustion of thin fluid are lost blood etc. and to be caused producing milk.The method of treatment hypogalactia or hypogalactia mainly contains dietetic therapy, drug application treatment etc. at present; Treatment by Chinese herbs in its Chinese medicine, as the Chinese medicine Semen Vaccariae, Squama Manis, leakage calabash etc. of selecting dredging collateral for promoting lactation for use for seeing more.
The present invention is that the screening compositions obtains having a kind of drug regimen that clearly promotes Lactation from Chinese medicine, can reach the promotion lactogenic, and have no side effect, and the personage who is suitable for puerperal hypogalactia or hypogalactia takes.
Chinese invention patent publication number CN1159333A once disclosed " a kind of oral liquid and growing method that promotes lactogenic ", adopted Rhizoma Dioscoreae, Semen Nelumbinis, and unfresh towel gourd, Fructus Lycii, Unguis Sus domestica, preparations such as Pericarpium Citri Reticulatae promote galactopoiesis and improve the oral liquid of milk quality; Chinese invention patent publication number CN1660213A once disclosed " a kind of oral preparation of Chinese traditional medicinal and preparation method that promotes lactogenic ", adopted Concha Ostreae extract, and Radix Astragali extract and lactalbumin powder are made the oral preparation of Chinese traditional medicinal that promotes lactogenic; Chinese invention patent publication number CN1895402A once disclosed " a kind of Chinese medicine preparation that promotes lactogenic and preparation method thereof ", adopted Rhizoma Dioscoreae Nipponicae, Radix Salviae Miltiorrhizae, Fructus Chaenomelis, Flos Rosae Chinensis, Radix Et Caulis Acanthopanacis Senticosi, Colla Corii Asini, Fructus Mori to form.
Summary of the invention
The object of the invention provides a kind of Chinese medicine composition in the application that promotes galactopoiesis.
Another object of the present invention provides the preparation method of this Chinese medicine composition.
The present invention according to the rule of treatment of " nourishing yin and promoting blood circulation ", selects five kinds of Chinese medicine applied in any combination such as Herba Ipomoeae Cairicae, Herba Cistanches, Cortex Cinnamomi, Herba Taxilli, Fructus Crataegi according to the understanding of theory of Chinese medical science to galactopoiesis in the Chinese medicine preparation that promotes lactogenic.
Herba Ipomoeae Cairicae, sweet in the mouth, cold is gone into liver, lung, kidney, urinary bladder channel; Herba Cistanches, sweet in the mouth, tepor are gone into kidney, large intestine channel; Cortex Cinnamomi, acrid in the mouth, sweet, hot is returned spleen, kidney, the heart, Liver Channel.Herba Taxilli, bitter in the mouth, sweet, flat is returned liver, kidney channel.Fructus Crataegi, sour, sweet, tepor are returned spleen, stomach, Liver Channel.All medicines share the effect that plays nourishing yin and promoting blood circulation.
Each the component raw material consumption for preparing this compositions is: Herba Ipomoeae Cairicae 5-30 part, Herba Cistanches 5-30 part, Cortex Cinnamomi 5-30 part, Herba Taxilli 5-30 part and Fructus Crataegi 5-30 part.
Be preferably: 12 parts of Herba Ipomoeae Cairicaes, 18 parts of Herba Cistanches, 5 parts of Cortex Cinnamomis, 5 parts of 18 parts of Herba Taxillis and Fructus Crataegis.
Pharmaceutical composition of the present invention can adopt the preparation method commonly used of Chinese medicine preparation to make fine powder; Adopt the Chinese medicine preparation conventional method to be prepared into conventional oral formulations, as tablet, capsule, oral liquid, electuary etc.
With Herba Ipomoeae Cairicae, Herba Cistanches, Cortex Cinnamomi, Herba Taxilli and Fructus Crataegi mix according to above-mentioned weight ratio, add 10 times of water gagings, soak 1.5 hours, and heating decocted 2.5 hours, filtered; Medicinal residues add 6 times of water gagings again, and heating decocts, and decocting time is 2 hours, filter, and filtrate merges, and separate solid content.Concentrated filtrate to relative density is 1.08-1.12, advances spray dryer, 140 ℃ of inlet temperature controls, and 105 ℃ of leaving air temps, 65 rev/mins of nebulizer rotating speeds, charging rate is 5ml/ minute, gets spray drying powder, pulverizes, and can get fine powder after sieving.This fine powder is Chinese medicine composition of the present invention.
This fine powder can directly add adjuvant etc., makes the Chinese medicine preparation that promotes lactogenic by the conventional preparation method of pharmaceutics of Chinese drugs.
The invention will be further elaborated below in conjunction with embodiment.
The preparation of embodiment 1 present composition (is example with 10 times of material proportional quantities)
It is standby to take by weighing each crude drug by following weight proportion: Herba Ipomoeae Cairicae 120 grams, and Herba Cistanches 180 grams, Cortex Cinnamomi 50 grams, Herba Taxilli 180 grams and Fructus Crataegi 50 restrain.The Herba Ipomoeae Cairicae of above-mentioned weight proportion, Herba Cistanches, Cortex Cinnamomi, Herba Taxilli and Fructus Crataegi mix according to above-mentioned weight ratio, add 10 times of calorimetric water logging bubbles 1.5 hours, and heating decocts 2.5 hours after-filtration; Medicinal residues add 6 times of water gagings again, and heating decocts 2 hours after-filtration, and filtrate merges, and separate solid content.Above-mentioned gained liquid concentration to relative density is 1.10, advances spray dryer, 140 ℃ of inlet temperature controls, and 105 ℃ of leaving air temps, 65 rev/mins of nebulizer rotating speeds, charging rate is 5ml/ minute, gets spray drying powder, pulverizes, and can get fine powder 70 grams after sieving.
Embodiment 2 present composition preparation tablets (is example with 10 times of material proportional quantities)
It is standby to take by weighing each crude drug by following weight proportion: Herba Ipomoeae Cairicae 120 grams, and Herba Cistanches 180 grams, Cortex Cinnamomi 50 grams, Herba Taxilli 180 grams and Fructus Crataegi 50 restrain.The Herba Ipomoeae Cairicae of above-mentioned weight proportion, Herba Cistanches, Cortex Cinnamomi, Herba Taxilli and Fructus Crataegi mix according to above-mentioned weight ratio, add 10 times of calorimetric water logging bubbles 1.5 hours, and heating decocts 2.5 hours after-filtration; Medicinal residues add 6 times of water gagings again, and heating decocts 2 hours after-filtration, and filtrate merges, and separate solid content.Above-mentioned gained liquid concentration to relative density is 1.10, advances spray dryer, 140 ℃ of inlet temperature controls, and 105 ℃ of leaving air temps, 65 rev/mins of nebulizer rotating speeds, charging rate is 5ml/ minute, gets spray drying powder, pulverizes, and can get fine powder 70 grams after sieving.This Chinese medicine composition fine powder adds adjuvant and makes granule, drying, and tabletting can get oral tablet.
Embodiment 3 present composition capsules preparations (is example with 10 times of material proportional quantities)
It is standby to take by weighing each crude drug by following weight proportion: Herba Ipomoeae Cairicae 120 grams, and Herba Cistanches 180 grams, Cortex Cinnamomi 50 grams, Herba Taxilli 180 grams and Fructus Crataegi 50 restrain.The Herba Ipomoeae Cairicae of above-mentioned weight proportion, Herba Cistanches, Cortex Cinnamomi, Herba Taxilli and Fructus Crataegi mix according to above-mentioned weight ratio, add 10 times of calorimetric water logging bubbles 1.5 hours, and heating decocts 2.5 hours after-filtration; Medicinal residues add 6 times of water gagings again, and heating decocts 2 hours after-filtration, and filtrate merges, and separate solid content.Above-mentioned gained liquid concentration to relative density is 1.10, advances spray dryer, 140 ℃ of inlet temperature controls, and 105 ℃ of leaving air temps, 65 rev/mins of nebulizer rotating speeds, charging rate is 5ml/ minute, gets spray drying powder, pulverizes, and can get fine powder 70 grams after sieving.This Chinese medicine composition fine powder adds adjuvant and makes particle drying, mixing, and the dress snap fit capsule can get oral capsule.
The effect evaluation of experimental example 1 present composition
60 female pregnant rats that are subjected to of SD, cleaning level animal, body weight 250 ± 20 grams; Animal is divided into 5 groups, i.e. blank group, model group, 3 dosage groups of high, medium and low drug regimen decocting liquid, 12 every group.Except that the blank group, all the other four groups of rats divide the 3rd day puerperium to take bromocriptine for female Mus with the dosage of 0.5mg/kg/d, and the group of medication simultaneously gives the decocting liquid of the composition of medicine of various dose.
Present composition decocting liquid adopts conventional decocting method preparation, and simmer down to respective concentration, medication group gastric infusion, decocting liquid various dose group comprises high dose group (10g/kg), middle dosage group (5g/kg), low dose group (2.5g/kg) is gastric infusion respectively, and all the other each groups gavage the equivalent normal saline, experiment successive administration totally 15 days.
The every nest in ZISHU birth back stays 12 female Mus of confession to feed, and divides the 3rd day puerperium, female Mus docking point blood sampling 1ml, blood sampling in later per 4 days 1 time, amount to 4 times, get the freezing preservation of serum system-20 ℃ refrigerator, use the PRL medicine box, measure serum Cui breast plain (PRL), each sample determination 2 times is averaged, and the results are shown in Table 1.After the 3rd day the 1st time blood sampling, each medication group suckling rat is irritated stomach respectively and gives the decocting liquid that the composition of medicine respective concentration gets, and model group and blank group give the normal saline of corresponding dosage.Body weight of per 4 Libras of ZISHU is represented the ZISHU body weight change with every nest average weight, the results are shown in Table 2.
Table 1 composition of medicine decocting liquid to the influence of P of Rats RL level in puerperal (x ± s, n=12)
△Blank group compares P＜0.01 with model group
*Medication group and model group be P＜0.01 relatively
Traditional Chinese medicine composition water decocting liquid of the present invention is obvious to the influence of PRL level, and high, normal, basic three dosage treated animal PRL levels of Chinese medicine composition of the present invention all raise to some extent after the 7th day, have compared significant differences P＜0.01 with model group PRL level.The short breast effect of Chinese medicine composition medicine of the present invention is described obviously.
Table 2 composition of medicine decocting liquid to the influence of ZISHU body weight (x ± s, n=12)
△Blank group compares P＜0.01 with model group
*Medication group and model group be P＜0.01 relatively
Chinese medicine composition medicine of the present invention is obvious to the influence of ZISHU body weight.Except that high dose group, respectively organized there was no significant difference between the ZISHU body weight on the 7th day; The the 11st and 15 day, the ZISHU body weight of the high, medium and low dosage group of Chinese medicine composition medicine of the present invention was compared the diversity (P＜0.01) that highly significant is arranged with model group ZISHU body weight; Point out composition of medicine of the present invention can promote galactopoiesis.
Claims (4)
1. Chinese medicine composition that is used to promote lactogenic, this Chinese medicine composition is to be made by following bulk drugs: Herba Ipomoeae Cairicae 5-30 part, Herba Cistanches 5-30 part, Cortex Cinnamomi 5-30 part, Herba Taxilli 5-30 part and Fructus Crataegi 5-30 part.
2. Chinese medicine composition according to claim 1, wherein the consumption of each crude drug is: 12 parts of Herba Ipomoeae Cairicaes, 18 parts of Herba Cistanches, 5 parts of Cortex Cinnamomis, 5 parts of 18 parts of Herba Taxillis and Fructus Crataegis.
3. Chinese medicine composition according to claim 1 and 2, it is prepared by the following step:
1) take by weighing Herba Ipomoeae Cairicae according to claim 1 or 2 described consumptions, Herba Cistanches, Cortex Cinnamomi, Herba Taxilli and Fructus Crataegi, standby;
2) with Herba Ipomoeae Cairicae, Herba Cistanches, Cortex Cinnamomi, Herba Taxilli and Fructus Crataegi mix according to above-mentioned weight ratio, add 8-12 times of calorimetric water; Soaked 1-2 hour; Heating decocts, the back timing of boiling, and decocting time is 2-3 hour, filters; Medicinal residues add 5-7 times of water gaging again, and heating decocts, the back timing of boiling, and decocting time is 1.5-2.5 hour, filters, filtrate merges, and separates solid content;
3) above-mentioned medicinal liquid being concentrated into relative density is 1.08-1.12, advances spray dryer, 130-150 ℃ of inlet temperature control, and leaving air temp 100-110 ℃, 55-75 rev/min of nebulizer rotating speed, charging rate is 4-6ml/ minute, gets spray drying powder;
4) spray drying powder is pulverized, and sieves, and gets fine powder.
4. Chinese medicine composition according to claim 1 is prepared into conventional oral formulations with it.
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| Application Number | Priority Date | Filing Date | Title |
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| CN 200910041971 CN101991673B (en) | 2009-08-19 | 2009-08-19 | Application of traditional Chinese medicine composition to promoting milk secretion, and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN 200910041971 CN101991673B (en) | 2009-08-19 | 2009-08-19 | Application of traditional Chinese medicine composition to promoting milk secretion, and preparation method thereof |
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| Publication Number | Publication Date |
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| CN101991673A CN101991673A (en) | 2011-03-30 |
| CN101991673B true CN101991673B (en) | 2011-11-16 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103284149B (en) * | 2013-05-20 | 2014-07-02 | 广州国宇医药科技有限公司 | Application of root-bark of omei linden in preparation of health care foods with function of promoting lactation |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1198932A (en) * | 1997-05-08 | 1998-11-18 | 张志兴 | Medicated wine |
| CN1249946A (en) * | 1999-09-15 | 2000-04-12 | 王怀庆 | Chinese medicine composition for treating breast cancer and its preparation |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1198932A (en) * | 1997-05-08 | 1998-11-18 | 张志兴 | Medicated wine |
| CN1249946A (en) * | 1999-09-15 | 2000-04-12 | 王怀庆 | Chinese medicine composition for treating breast cancer and its preparation |
Non-Patent Citations (2)
| Title |
|---|
| 姜海斌等.中药治疗产后缺乳的研究概况.《湖南中医药导报》.2003,第9卷(第1期),66-67. * |
| 陈凯佳等.200例痿病患者辨证用药规律探讨.《中华中医药学刊》.2008,第26卷(第5期),1067-1068. * |
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