CN102988801A - Traditional Chinese medicine composition for promoting milk secretion - Google Patents
Traditional Chinese medicine composition for promoting milk secretion Download PDFInfo
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- CN102988801A CN102988801A CN2012104397196A CN201210439719A CN102988801A CN 102988801 A CN102988801 A CN 102988801A CN 2012104397196 A CN2012104397196 A CN 2012104397196A CN 201210439719 A CN201210439719 A CN 201210439719A CN 102988801 A CN102988801 A CN 102988801A
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Abstract
The invention discloses a traditional Chinese medicine composition for promoting milk secretion. The traditional Chinese medicine composition comprises Chuanminshen violaceum, semen plantaginis, boehmeria spicata, vanilla and Aristolochia impressinervis C.F.Liang. According to the traditional Chinese medicine composition for promoting milk secretion, the traditional Chinese medicines are used as the raw materials, so that no toxic and side effects are brought; and the traditional Chinese medicine composition can be prepared into traditional Chinese medicine preparation which is suitable for a puerpera undergoing jack of postpartum lactation or hypogalactia.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition that promotes lactogenic, belong to the field of Chinese medicines.。
Background technology
The secretory cell of mammary gland tissue, in the blood various nutrient substance as raw material, in cell, generate milk after, be secreted into the process in the alveolar lumen, be called galactopoiesis; Milk in the glandular cell chamber by the tubing of mammary gland tissue, compiles step by step, flows to externally finally by breast duct and papillary duct, and this process is called milk ejection; This two property of galactopoiesis and milk ejection process different and that connect each other is collectively referred to as lactogenic.
The nutrient substance such as breast milk rich in proteins, fat, sugar; and contain the multiple nonspecific immunity materials such as complement, bifidus factor; have the protection baby and support the ability of disturbing infected by microbes; so the breast milk best wholefood breast feeding that is the baby can not only be satisfied baby's nutritional need; but also for baby's resist the disease provides antibody, it is the key factor of children's health existence.Cesarean lactation is complicated physiological process, and except being subject to the factor affecting such as multiple hormone, also relevant with factors such as puerpera's nutrition, spirit, psychology, the stimulation of some medicines also produces important impact to lactogenic in addition.But the factors of the modern life has many puerperas puerperal without milk or hypogalactia juice.
Medical science is thought now, and galactopoiesis is regulated with keeping by nerve-hormone approach between lactation period; The prolacrin of anterior lobe of hypophysis secretion is suppressed by a large amount of estrogen and the progesterone of Placenta Hominis and ovarian secretion at pregnancy duration; In a minute puerperium, because progesterone content descends suddenly, cause that prolacrin discharges rapidly; Mammary gland tissue causes galactopoiesis under the strong effect of prolacrin, after this, owing to contain all the time the prolacrin of certain level in the blood, lactogenic is maintained.
Tcm theory is thought body fluid blood homology, and milk is the life of parent QI and blood, and QI and blood is the material base that milk generates; The reason of hypogalactia has deficiency and excess two aspects: real person is functional activity of QI being not smooth, and QI and blood is obstructed, galactozemia, hypogalactia; Void person is the body deficiency of qi and blood, and the biochemical deficiency of essence of water and grain or exhaustion of thin fluid are lost blood etc. and to be caused producing milk.The method for the treatment of hypogalactia or hypogalactia mainly contains dietetic therapy, physiotherapy, Drug therapy etc. at present, puerpera's the first-selection often of the treatment by Chinese herbs in the pharmacotherapy wherein, often selected such as the benefiting vital QI and blood such as Radix Angelicae Sinensis, Radix Codonopsis, Semen Vaccariae, Squama Manis, leakage calabash, the stimulating milk secretion of stimulating the menstrual flow Chinese crude drug.
The present invention screens compositions from Chinese medicine, obtain having a kind of Chinese medicine composition that promotes Lactation, reaches to promote lactogenic and the purpose that has no side effect, and the personage who is suitable for puerperal hypogalactia or hypogalactia takes.
Chinese invention patent publication number CN101785797A discloses " a kind of medicine and preparation method that promotes lactogenic, increases nutrition of breast milk ", it is comprised of Semen Vaccariae, dry yeast, Ferrous gluconate, calcium gluconate, vitamin A, vitamin, and this drug regimen comprises the compositions such as Chinese crude drug and trace element; Chinese invention patent publication number CN102370936A discloses " a kind of Chinese medicine composition that promotes lactogenic and preparation method thereof ", and it is that raw material forms by Flos Pruni mume, Cortex Kalopanacis, Fructus Tribuli, Rhizoma Wenyujin Concisum, Herba Pteridis Multifidae; Chinese invention patent publication number CN1159333A discloses " a kind of oral liquid and growing method that promotes lactogenic ", and it adopts Rhizoma Dioscoreae, Semen Nelumbinis, and unfresh towel gourd, Fructus Lycii, Unguis Sus domestica, the preparations such as Pericarpium Citri Reticulatae promote galactopoiesis and improve the oral liquid of milk quality; Chinese invention patent publication number CN1660213A discloses " a kind of oral preparation of Chinese traditional medicinal and preparation method that promotes lactogenic ", and it adopts Concha Ostreae extract, and Radix Astragali extract and lactalbumin powder are made the oral preparation of Chinese traditional medicinal that promotes lactogenic.
Summary of the invention
The object of the invention provides a kind of Chinese medicine composition in the application that promotes galactopoiesis.
Another object of the present invention provides the preparation method of this Chinese medicine composition.
The present invention, selects the bright ginseng in river, Semen Plantaginis, red fiber crops, Cymbopogon distans (Nees)A. Camus and wears stone rattan five tastes medical material applied in any combination in the Chinese medicine preparation that promotes lactogenic according to the rule for the treatment of of " benefiting QI for activating blood circulation " according to the understanding of theory of Chinese medical science to galactopoiesis.
The bright ginseng in river, sweet in the mouth, little hardship, cool in nature enter liver, spleen, lung meridian, play the spleen invigorating effect; Semen Plantaginis, is slightly cold at sweet in the mouth, enters liver, kidney, lung, small intestine meridian, plays heat clearing away eliminating dampness by diuresis effect; Red fiber crops, mildly bitter flavor, property are flat, play the heat clearing away effect of stimulating the menstrual flow; Cymbopogon distans (Nees)A. Camus, mildly bitter flavor, property suffering, warm play the invigorating spleen for diuresis effect; Wear the stone rattan, mildly bitter flavor, property are hot, warm, play the collateral dredging effect of invigorating blood circulation.All medicines share and play invigorating the spleen and benefiting QI, the effect that collateral dredging is invigorated blood circulation.
Each the component raw material consumption for preparing this compositions is: river bright ginseng 5-30 part, Semen Plantaginis 5-30 part, red numb 5-30 part, Cymbopogon distans (Nees)A. Camus 5-30 part and wear stone rattan 5-30 part.
Be preferably: 15 parts of the bright ginsengs in river, 9 parts of Semen Plantaginiss, red numb 12 parts, 9 parts of Cymbopogon distans (Nees)A. Camus and wear 12 parts in stone rattan.
Pharmaceutical composition of the present invention can adopt the preparation method of Chinese medicine preparation to make fine powder, and can be prepared into conventional oral formulations, such as tablet, capsule, oral liquid, electuary etc.
With the bright ginseng in river, Semen Plantaginis, red fiber crops, Cymbopogon distans (Nees)A. Camus and wear the stone rattan and mixes according to above-mentioned weight ratio adds 8 times of calorimetric water, soaks 1.5 hours, and the heating decoction decocted 1.5 hours, filtration; Medicinal residues add 6 times of water gagings again, and heating decocts, and decocting time is 1 hour, filter; Filtrate merges, and separates solid content; It is 1.08 that above-mentioned medicinal liquid is concentrated into relative density, advances spray dryer, 140 ℃ of inlet temperature controls, and 110 ℃ of leaving air temps, 45 rev/mins of nebulizer rotating speeds, charging rate is 5 ml/ minutes, gets spray drying powder, pulverizes, and can get fine powder after sieving.This fine powder is Chinese medicine composition of the present invention, and this fine powder can directly add adjuvant etc., makes the Chinese medicine preparation that promotes lactogenic by the conventional preparation method of pharmaceutics of Chinese drugs.
The invention will be further elaborated below in conjunction with embodiment.
The preparation of embodiment 1 present composition (take 10 times of material proportional quantities as example)
It is for subsequent use to take by weighing each crude drug by following weight proportion: bright ginseng 150 grams in river, and Semen Plantaginis 90 grams, red numb 120 grams, Cymbopogon distans (Nees)A. Camus 90 restrains and wears stone rattan 120 grams.The bright ginseng in the river of above-mentioned weight proportion, Semen Plantaginis, red fiber crops, Cymbopogon distans (Nees)A. Camus and wear the stone rattan and mixes according to above-mentioned weight ratio adds 8 times of calorimetric water, soaks 1.5 hours, and the heating decoction decocted 1.5 hours, filtration; Medicinal residues add 6 times of water gagings again, and heating decocts, and decocting time is 1 hour, filter; Filtrate merges, and separates solid content; It is 1.08 that above-mentioned medicinal liquid is concentrated into relative density, advances spray dryer, 140 ℃ of inlet temperature controls, and 110 ℃ of leaving air temps, 45 rev/mins of nebulizer rotating speeds, charging rate is 5 ml/ minutes, gets spray drying powder, pulverizes, and can get fine powder 30 grams after sieving.
The preparation of embodiment 2 present compositions (take 10 times of material proportional quantities as example)
It is for subsequent use to take by weighing each crude drug by following weight proportion: bright ginseng 50 grams in river, and Semen Plantaginis 50 grams, red numb 50 grams, Cymbopogon distans (Nees)A. Camus 50 restrains and wears stone rattan 50 grams.The bright ginseng in the river of above-mentioned weight proportion, Semen Plantaginis, red fiber crops, Cymbopogon distans (Nees)A. Camus and wear the stone rattan and mixes according to above-mentioned weight ratio adds 6 times of calorimetric water, soaks 1 hour, and the heating decoction decocted 1 hour, filtration; Medicinal residues add 4 times of water gagings again, and heating decocts, and decocting time is 0.5 hour, filter; Filtrate merges, and separates solid content; It is 1.06 that above-mentioned medicinal liquid is concentrated into relative density, advances spray dryer, 130 ℃ of inlet temperature controls, and 100 ℃ of leaving air temps, 40 rev/mins of nebulizer rotating speeds, charging rate is 4 ml/ minutes, gets spray drying powder, pulverizes, and can get fine powder 10 grams after sieving.
The preparation of embodiment 3 present compositions (take 10 times of material proportional quantities as example)
It is for subsequent use to take by weighing each crude drug by following weight proportion: bright ginseng 300 grams in river, and Semen Plantaginis 300 grams, red numb 300 grams, Cymbopogon distans (Nees)A. Camus 300 restrains and wears stone rattan 300 grams.The bright ginseng in the river of above-mentioned weight proportion, Semen Plantaginis, red fiber crops, Cymbopogon distans (Nees)A. Camus and wear the stone rattan and mixes according to above-mentioned weight ratio adds 8 times of calorimetric water, soaks 2 hours, and the heating decoction decocted 1.5 hours, filtration; Medicinal residues add 6 times of water gagings again, and heating decocts, and decocting time is 1 hour, filter; Filtrate merges, and separates solid content; It is 1.10 that above-mentioned medicinal liquid is concentrated into relative density, advances spray dryer, 140 ℃ of inlet temperature controls, and 110 ℃ of leaving air temps, 50 rev/mins of nebulizer rotating speeds, charging rate is 5ml/ minute, gets spray drying powder, pulverizes, and can get fine powder 80 grams after sieving.
Embodiment 4 present composition tablets preparations (take 10 times of material proportional quantities as example)
It is for subsequent use to take by weighing each crude drug by following weight proportion: bright ginseng 150 grams in river, and Semen Plantaginis 90 grams, red numb 120 grams, Cymbopogon distans (Nees)A. Camus 90 restrains and wears stone rattan 120 grams.The bright ginseng in the river of above-mentioned weight proportion, Semen Plantaginis, red fiber crops, Cymbopogon distans (Nees)A. Camus and wear the stone rattan and mixes according to above-mentioned weight ratio adds 8 times of calorimetric water, soaks 1.5 hours, and the heating decoction decocted 1.5 hours, filtration; Medicinal residues add 6 times of water gagings again, and heating decocts, and decocting time is 1 hour, filter; Filtrate merges, and separates solid content; It is 1.08 that above-mentioned medicinal liquid is concentrated into relative density, advances spray dryer, 140 ℃ of inlet temperature controls, and 110 ℃ of leaving air temps, 45 rev/mins of nebulizer rotating speeds, charging rate is 5 ml/ minutes, gets spray drying powder, pulverizes, and can get fine powder 30 grams after sieving.This Chinese medicine composition fine powder adds the adjuvant granulation, drying, and tabletting can get oral tablet.
Embodiment 5 present composition capsules preparations (take 10 times of material proportional quantities as example)
It is for subsequent use to take by weighing each crude drug by following weight proportion: bright ginseng 300 grams in river, and Semen Plantaginis 300 grams, red numb 300 grams, Cymbopogon distans (Nees)A. Camus 300 restrains and wears stone rattan 300 grams.The bright ginseng in the river of above-mentioned weight proportion, Semen Plantaginis, red fiber crops, Cymbopogon distans (Nees)A. Camus and wear the stone rattan and mixes according to above-mentioned weight ratio adds 8 times of calorimetric water, soaks 2 hours, and the heating decoction decocted 1.5 hours, filtration; Medicinal residues add 6 times of water gagings again, and heating decocts, and decocting time is 1 hour, filter; Filtrate merges, and separates solid content; It is 1.10 that above-mentioned medicinal liquid is concentrated into relative density, advances spray dryer, 140 ℃ of inlet temperature controls, and 110 ℃ of leaving air temps, 50 rev/mins of nebulizer rotating speeds, charging rate is 5ml/ minute, gets spray drying powder, pulverizes, and can get fine powder 80 grams after sieving.This Chinese medicine composition fine powder adds adjuvant granulation drying, mixing, and the dress snap fit capsule can get oral capsule.
The effect evaluation of experimental example 1 present composition
50 of the female Pregnant rats of cleaning level SD, body weight 250 ± 20 grams, rat at random animal is grouped into 5 groups, i.e. blank group, model group, 3 dosage groups of high, medium and low drug regimen decocting liquid, 10 every group.Except the blank group, all the other four groups of rats divide the 3rd day puerperium to take bromocriptine with the dosage of 0.5mg/kg/d to female Mus, and simultaneously medication group gives the decocting liquid of the composition of medicine of various dose.
Present composition decocting liquid adopts conventional decocting method preparation, and simmer down to respective concentration, medication group gastric infusion, decocting liquid various dose group comprises high dose group (20g/kg), middle dosage group (10g/kg), low dose group (5g/kg) is gastric infusion respectively, and all the other each groups gavage the equivalent normal saline, experiment successive administration totally 14 days.
Every nest stays 12 female Mus of confession to feed after the ZISHU birth, and in minute the 3rd day puerperium, female Mus docking point blood sampling 1ml blood sampling in the 3rd, 7,14 day, gets serum system-20 respectively
OThe C refrigerator freezing is preserved, and uses the PRL medicine box, measures Prolactin (PRL), and each sample determination 2 times is averaged, and the results are shown in Table 1.
Table 1 traditional Chinese medicine composition water decocting liquid of the present invention on the impact of P of Rats RL level in puerperal (
± s, n=10)
Δ represents blank group and compares with model group
P＜0.05 * represents the medication group and model group compares
P＜0.05
Chinese medicine composition of the present invention is obvious to PRL level affects in the rat body, and three dosage groups of the 7th and 14 day Chinese medicine composition of the present invention raise to some extent to P of Rats RL level, with model group significant difference are arranged relatively
P＜0.05; Point out Chinese medicine composition of the present invention to have prolactin antagonist effect in the rat of the raising body.
After the 3rd day the 1st time blood sampling, each medication group suckling rat respectively gavage gives composition of medicine variable concentrations decocting liquid, and model group and blank group give the normal saline of corresponding dosage.Per 3,7,14 days difference of ZISHU scale body weight represents the ZISHU body weight change with every nest average weight, the results are shown in Table 2.
Table 2 traditional Chinese medicine composition water decocting liquid of the present invention on the impact of ZISHU body weight (
± s, n=10)
Δ represents blank group and compares with model group
P＜0.05 * represents the medication group and model group compares
P＜0.05
Chinese medicine composition of the present invention is obvious to ZISHU body weight influence, and wherein the 7th day ZISHU body weight respectively organized there was no significant difference between the ZISHU body weight except high dose group; The 14th day ZISHU body weight, the ZISHU body weight of three dosage groups of Chinese medicine composition of the present invention compared with model group significant difference (
P＜0.05), prompting Chinese medicine composition of the present invention has the effect of the galactopoiesis of promotion.
Claims (4)
1. Chinese medicine composition that be used for to promote lactogenic, this Chinese medicine composition is to be made by the crude drug of following weight portion: river bright ginseng 5-30 part, Semen Plantaginis 5-30 part, red numb 5-30 part, Cymbopogon distans (Nees)A. Camus 5-30 part with wear stone rattan 5-30 part.
2. Chinese medicine composition according to claim 1, wherein the consumption of each crude drug is: 15 parts of the bright ginsengs in river, 9 parts of Semen Plantaginiss, red numb 12 parts, 9 parts of Cymbopogon distans (Nees)A. Camus and wear 12 parts in stone rattan.
3. Chinese medicine composition according to claim 1 and 2, it is by the following step preparation:
1) described consumption takes by weighing the bright ginseng in river according to claim 1 and 2, Semen Plantaginis, and red fiber crops, Cymbopogon distans (Nees)A. Camus and wear the stone rattan, for subsequent use;
2) with the bright ginseng in river, Semen Plantaginis, red fiber crops, Cymbopogon distans (Nees)A. Camus and wear the stone rattan and mixes according to above-mentioned weight ratio adds 6-8 times of calorimetric water, soaks 1-2 hour, and the heating decoction decocted 1-1.5 hour, filtration; Medicinal residues add 4-6 times of water gaging again, and heating decocts, and decocting time is 0.5-1 hour, filter; Filtrate merges, and separates solid content;
3) above-mentioned medicinal liquid being concentrated into relative density is 1.06-1.10, advances spray dryer, 130-140 ℃ of inlet temperature control, and leaving air temp 100-110 ℃, 40-50 rev/min of nebulizer rotating speed, charging rate is 4-5 ml/ minute, gets spray drying powder;
4) spray drying powder is pulverized, and sieves, and gets fine powder.
4. Chinese medicine composition according to claim 1 is prepared into conventional oral formulations with it.
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| CN2012104397196A CN102988801A (en) | 2012-11-07 | 2012-11-07 | Traditional Chinese medicine composition for promoting milk secretion |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103284149A (en) * | 2013-05-20 | 2013-09-11 | 广州国宇医药科技有限公司 | Application of root-bark of Omei linden in preparation of health care foods with function of promoting lactation |
| CN106039002A (en) * | 2016-06-08 | 2016-10-26 | 广州国宇医药科技有限公司 | Traditional Chinese medicine composition capable of promoting lactation and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101461923A (en) * | 2009-01-07 | 2009-06-24 | 唐金生 | Health-care nasal liquid for giving up smoking |
-
2012
- 2012-11-07 CN CN2012104397196A patent/CN102988801A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101461923A (en) * | 2009-01-07 | 2009-06-24 | 唐金生 | Health-care nasal liquid for giving up smoking |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103284149A (en) * | 2013-05-20 | 2013-09-11 | 广州国宇医药科技有限公司 | Application of root-bark of Omei linden in preparation of health care foods with function of promoting lactation |
| CN103284149B (en) * | 2013-05-20 | 2014-07-02 | 广州国宇医药科技有限公司 | Application of root-bark of omei linden in preparation of health care foods with function of promoting lactation |
| CN106039002A (en) * | 2016-06-08 | 2016-10-26 | 广州国宇医药科技有限公司 | Traditional Chinese medicine composition capable of promoting lactation and preparation method thereof |
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Application publication date: 20130327 |