CN100402081C - Chinese patent medicine for treating gynaecologic disease and preparing method - Google Patents
Chinese patent medicine for treating gynaecologic disease and preparing method Download PDFInfo
- Publication number
- CN100402081C CN100402081C CNB2005100217508A CN200510021750A CN100402081C CN 100402081 C CN100402081 C CN 100402081C CN B2005100217508 A CNB2005100217508 A CN B2005100217508A CN 200510021750 A CN200510021750 A CN 200510021750A CN 100402081 C CN100402081 C CN 100402081C
- Authority
- CN
- China
- Prior art keywords
- radix
- rhizoma
- powder
- medicine
- processed
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Abstract
The present invention discloses a Chinese patent medicine for curing gynaecologic diseases and a preparing method thereof. The Chinese patent medicine is prepared from more than 30 medicines such as ginseng, notoginseng, donkey-hide glue, antler, angelica, prepared rehmannia root, safflower, deglued antler, white peony root, barbary wolfberry fruit, black bean, himalayan teasel root, etc. Each traditional Chinese medicine preparation overcomes the disadvantage that medical efficacy of the existing gynaecologic medicines is lopsided. The Chinese patent medicine has the efficacy of clearing heat, promoting diuresis, regulating the blood and menstruation, invigoration and strengthening body resistance, and has good therapeutic effects on curing gynecological inflammation, qi and blood deficiency and blood and menstruation regulation. Each medicine preparation of the present invention has different characteristics that capsules have portability, little addition of auxiliary materials, little dosage and low content of pesticide residue and heavy metal, can block medical harmful smell, and the products are easy to disintegrate and absorb; tablets have stable quality, concentrated effective component and high biologic availability, lots of impurities are removed, and the influence of air and moisture on the tablets is improved by adding auxiliary materials; granule preparations have low stimulation for gastrointestinal tracts, large medicine loading quantity and good mouth feel, and are favorable for the receiving of female patients; soft capsules reserve the component of volatile oil the preparations, and block medical harmful smell.
Description
[technical field]
The invention belongs to technical field of Chinese medicines, specifically, is a kind of Chinese patent medicine for the treatment of gynaecopathia and preparation method thereof.
[background technology]
The Chinese patent medicine of treatment gynaecopathia mainly comprises heat-clearing and diuresis-promoting drug, treating blood disorders emmenagogue and tonification drug supporting healthy energy three major types.
Heat-clearing and diuresis-promoting drug such as HUAHONG JIAONANG, FUKE QIANJIN PIAN etc.The HUAHONG JIAONANG clearing away heat-damp and promoting diuresis, stasis-dispelling and pain-killing is used for profuse leukorrhea, and yellow skin matter is thick, diseases such as inferior belly gas pain; The FUKE QIANJIN PIAN removing damp-heat, benefiting qi and removing blood stasis is used for the morbid leukorrhea due to the dampness and heat stasis, chronic pelvic inflammatory disease, endometritis, chronic cervicitis.This type of efficacy of drugs focuses on blood stasis dispelling, antiinflammatory.
Treating blood disorders emmenagogue such as FUKE ZAIZAO WAN, ease pill, Herba Leonuri paste etc.The FUKE ZAIZAO WAN nourishing blood for regulating menstruation, liver and kidney tonifying, warm palace pain relieving is used for menstruation irregularly successively, and menostaxis is dripping hemorrhage, dysmenorrhea, diseases such as leukorrhagia; The ease pill soothing liver and strengthening spleen, nourishing blood for regulating menstruation is used for gloomy due to the stagnation of liver-QI with deficiency of the spleen and does not relax, and distending pain in the chest and hypochondrium is had a dizzy spell, loss of appetite, menoxenia; The Herba Leonuri paste promoting blood flow to regulate menstruation is used for menoxenia, prolonged lochia due to the blood stasis etc.This type of efficacy of drugs focuses on treating blood disorders, regulating menstruation, pain relieving.
Tonification drug supporting healthy energy such as NVJIN WAN, WUJI BAIFENG WAN.The NVJIN WAN kidney-replenishing blood-nourishing, adjusting meridian and stopping leukorrhea is used for the menoxenia that the deficiency of the kidney blood deficiency causes, profuse leukorrhea, lassitude loin and legs, lower abdomen pain; The WUJI BAIFENG WAN benefiting qi and nourishing blood, adjusting meridian and stopping leukorrhea is used for QI and blood deficiency, asthenic body, soreness of the waist and knees, menoxenia, bleeding not during menses.This type of efficacy of drugs focuses on tonify deficiency, thereby reaches the effect of adjusting meridian and stopping leukorrhea.
Seldom have in the Chinese patent medicine of treatment gynaecopathia at present and take into account the kind that three effects are set upright in clearing away heat-damp and promoting diuresis, treating blood disorders regulating menstruation and tonification, and gynaecopathia is adult women's a commonly encountered diseases, frequently-occurring disease, its clinical manifestation is varied, pathology is complicated and often with multiple complications, and clinical common asthenia of qi and blood is held concurrently the patient of stasis of blood disease usually also with gynecological inflammation.Therefore, the patient will take not only that tonification is set upright, the regulating blood condition medicine, also must take clearing away heat-damp and promoting diuresis class medicine simultaneously, and gynaecopathia is a chronic disease, need take medicine for a long time, takes multiple medicine for a long time, female patient is felt to be difficult to comply with, and patient treatment drug cost height, and economic pressures are big.
In addition, the dosage form great majority of such patent medicine all are traditional pill, unguentum at present, are prescription is respectively distinguished the flavor of the crude drug pulverize separately for last that mix homogeneously adds making pellets by mixing medical powder with honey or adds soft extract.Its shortcoming is: harmful substance contents height such as the pesticide residues in the crude drug, heavy metal, and toxic and side effects is big, diminishes patient's health; After medical material was all pulverized, powder directly was used as medicine without extraction, and bioavailability is low, and the wasting of resources; Especially modern medicinal agents studies show that, the main effective ingredient of the aromatics medicine such as the Rhizoma Atractylodis Macrocephalae, Rhizoma Cyperi, Radix Bupleuri, Cortex Cinnamomi, Fructus Amomi, Herba Asari, Radix Angelicae Sinensis, Rhizoma Chuanxiong etc. is a volatile oil, and crude drug powder is used as medicine, and its volatile oil is more difficult separates out; The ratio that invalid components accounts in the patent medicine is big, and patient's medication dose is big, the misery of taking medicine; Sugar content height in the adjuvant, the patient of complication with diabetes should not take, and suitable crowd is limited to.
[summary of the invention]
[goal of the invention]
Primary and foremost purpose of the present invention provides the Chinese patent medicine of a kind of indication treatment gynecological disease wider, evident in efficacy.The coordination that this medicine is considered Chinese medicine preparation according to the theory of Chinese medical science scientific composition, takes into account clearing away heat-damp and promoting diuresis, treating blood disorders regulating menstruation and tonification and sets upright a plurality of effects, at treatment gynecological inflammation, asthenia of qi and blood, the tripartite mask for the treatment of blood disorders regulating menstruation better curative effect is arranged.
Another object of the present invention provides the preparation method of a kind of medicine.The drug product quality of this method preparation is stable, and active constituent content height, toxic and side effects are little, and invalid components such as pesticide residues and heavy metal are few, small product size is little, taking convenience, is easy to carry and stores.
[technical scheme]
The objective of the invention is to realize like this:
The Chinese patent medicine of treatment gynaecopathia of the present invention, make (consumption is a weight portion) by following component:
Radix Ginseng 27～220, Cornu Cervi Pantotrichum 27～220, Radix Rehmanniae Preparata 135～1100, Radix Angelicae Sinensis 135～1100, Stigma Croci 4～32, Flos Carthami 35～300, Radix Notoginseng 33～300, Colla Corii Asini 27～220, Cornu Cervi Degelatinatum 67～600, the Radix Paeoniae Alba 40～330, Fructus Lycii 40～330, Herba Leonuri 6～60, Oletum Trogopterori 6～60, Yunnan Caulis Spatholobi cream powder 7～60, Poria 5～44, the Rhizoma Atractylodis Macrocephalae 40～330, Fructus Leonuri 6～60, Rhizoma Chuanxiong 4～40, Rhizoma Cyperi 6～60, Radix Bupleuri 5～44, the Radix Linderae 4～40, Rhizoma Corydalis 6～60, Radix Scutellariae 2～22, Fructus Amomi 2～22, the Cortex Eucommiae 5～44, Rhizoma Zingiberis 5～44, Herba Asari 2～20, Radix Cyathulae 4～50, Cortex Cinnamomi 2～22, Radix Glycyrrhizae 6～60, Radix Dipsaci 1.8～20, Semen sojae atricolor 0.4～4.0, Oryza glutinosa 14～140, maltose 10～100.
Formula optimization weight (part) ratio range of preparation Chinese patent medicine of the present invention is:
Radix Ginseng 54～120, Cornu Cervi Pantotrichum 54～120, Radix Rehmanniae Preparata 270～560, Radix Angelicae Sinensis 270～550, Stigma Croci 8～20, Flos Carthami 70～180, Radix Notoginseng 66～150, Colla Corii Asini 54～150, Cornu Cervi Degelatinatum 134～350, the Radix Paeoniae Alba 80～180, Fructus Lycii 80～180, Herba Leonuri 12～35, Oletum Trogopterori 12～35, Yunnan Caulis Spatholobi cream powder 14～35, Poria 10～25, the Rhizoma Atractylodis Macrocephalae 80～180, Fructus Leonuri 12～30, Rhizoma Chuanxiong 8～20, Rhizoma Cyperi 12～35, Radix Bupleuri 10～25, the Radix Linderae 8～20, Rhizoma Corydalis 12～35, Radix Scutellariae 4～16, Fructus Amomi 4～16, the Cortex Eucommiae 10～25, Rhizoma Zingiberis 10～25, Herba Asari 4～12, Radix Cyathulae 8～30, Cortex Cinnamomi 4～16, Radix Glycyrrhizae 12～35, Radix Dipsaci 3.6～10, Semen sojae atricolor 0.8～1.8, Oryza glutinosa 28～80, maltose 20～50.
The optimum weight of Chinese patent medicine of the present invention (part) proportioning is:
Radix Ginseng 108, Cornu Cervi Pantotrichum 108, Radix Rehmanniae Preparata 540, Radix Angelicae Sinensis 540, Stigma Croci 16, Flos Carthami 146.68, Radix Notoginseng 135, Colla Corii Asini 108, Cornu Cervi Degelatinatum 270, the Radix Paeoniae Alba 162, Fructus Lycii 162, Herba Leonuri 27, Yunnan Caulis Spatholobi cream powder 29.53, Oletum Trogopterori 27, Poria 22, the Rhizoma Atractylodis Macrocephalae 162, Fructus Leonuri 27, Rhizoma Chuanxiong 16, Rhizoma Cyperi 27, Radix Bupleuri 22, the Radix Linderae 16, Rhizoma Corydalis 27, Radix Scutellariae 11, Fructus Amomi 11, the Cortex Eucommiae 22, Rhizoma Zingiberis 22, Herba Asari 8, Radix Cyathulae 24.03, Cortex Cinnamomi 11, Radix Glycyrrhizae 27, Radix Dipsaci 7.16, Semen sojae atricolor 1.69, Oryza glutinosa 59.06, maltose 40.5.
The dosage form of medicine of the present invention is capsule, tablet, granule, soft capsule.
The source and the effect thereof of the Chinese crude drug that technique scheme is mentioned are as follows:
1. Radix Ginseng: this product is an Araliaceae.The blood disorder that goes out to syndrome of deficiency of blood, QI failing to control blood has QI invigorating and blood producing, effects such as nourishing qi to stop.Pharmacological research shows that the ginsenoside can prevent blood coagulation, promotes fibrinolysis, reduces erythrocytic aggregation, increases the flowability of blood, and analgesia promotes sexual maturity etc.
2. Cornu Cervi Pantotrichum: this product is the young horn of the unossified close living fine hair of stag of animal in deer family Cervus nippon Temminck or Cervus elaphus linnaeus.Have invigorating kidney-YANG, benefiting essence-blood is transferred the effect towards warp, is applicable to the soreness of the waist and knees of insufficiency of kidney-YANG more, and libido is indifferent, and cold womb is infertile, below element deficiency and cold, and Chong and Ren channel disorder, metrorrhagia is more than, and leukorrhagia too much waits card.Pharmaceutical research shows that the pharmacological action of Cornu Cervi Pantotrichum mainly shows and promotes the synthetic of protein, nucleic acid, promotes hemoposieis, raise immunity, sexual function improving, work efficiency and the anti-stress ability and the delaying senility function of raising body.
3. Radix Rehmanniae Preparata: this product is a goatweed.Have enrich blood, the effect of regulating menstruation.Its pharmacological action mainly shows anti-anemia effect, raise immunity etc.Radix Rehmanniae Preparata has and nourishes blood, YIN nourishing, and supplying vital essence and marrow is the key medicine of enriching blood.
4. Radix Angelicae Sinensis: this product is a samphire.Having enriches blood invigorates blood circulation, the effect of menstruction regulating and pain relieving, loosening bowel to relieve constipation.Radix Angelicae Sinensis is as the history in existing hundreds of years of gynecological's key medicine.Pharmacological research shows that Radix Angelicae Sinensis contains composition excited and the inhibition uterine smooth muscle simultaneously, suppresses composition and is mainly volatile oil and ferulic acid.Radix Angelicae Sinensis depends on the functional status in uterus and is dual regulation the effect in uterus, is its treatment dysmenorrhea, hastens parturition and the pharmacological basis of metrorrhagia.Strengthen the effect of blood circulation promoting and enriching behind the Radix Angelicae Sinensis processed with wine.
5. the Radix Paeoniae Alba: this product is a cohosh.Has the suppressing the hyperactive liver pain relieving, nourishing blood for regulating menstruation, the effect of astringing YIN to stop sweating.After wine is processed, reduce the cold property of acid, be good at and middle emergency, waist rib pain, stomachache, puerperal abdonimal pain answers wine to process especially.The Radix Paeoniae Alba plays pain relieving, nourishing blood for regulating menstruation in we.
6. Poria: this product is the Polyporaceae plant.Has promoting diuresis to eliminate damp pathogen, spleen invigorating, the effect of calming the nerves.
7. Colla Corii Asini: this product is that donkey skin is through decocting, concentrate the solid gum of making.Contain glutin and several amino acids, the YIN nourishing of enriching blood in we has anastalsis concurrently.
8. Radix Glycyrrhizae: this product is a leguminous plant.Has the spleen reinforcing stomach function regulating, Yiqi and vein recovery.Be used for weakness of the spleen and stomach, fatigue and weakness etc.
9. Rhizoma Chuanxiong: this product is a samphire.Acrid in the mouth, warm in nature.Return liver, gallbladder, pericardium channel.Have blood-activating and qi-promoting, the function of wind-expelling pain-stopping is " the gas medicine in the blood ".Rhizoma Zingiberis Recens is processed the back and relaxes side effect, heightens the effect of a treatment.
10. Radix Scutellariae: this product is a lip type section plant.Has heat clearing and damp drying, eliminating fire and detoxication, effects such as arresting bleeding and miscarriage prevention.
11. Fructus Lycii: this product is a plant of Solanaceae.Effect with nourishing the liver and kidney, replenishing vital essence to improve eyesight.
12. Stigma Croci: this product is an irides.Blood circulation promoting and blood stasis dispelling, clean blood resolving depression.Be used for amenorrhea, postpartum stagnation, maculae caused by violent heat pathogen etc.
13. Flos Carthami: this product is a feverfew.Acrid in the mouth, warm in nature.GUIXIN, Liver Channel have promoting blood circulation to remove obstruction in the collateral, the effect of eliminating stasis to stop pain.
14. Radix Notoginseng: this product is an Araliaceae.Have the dissipating blood stasis hemostasis, the effect of subduing swelling and relieving pain, sweet in the mouth, little hardship, warm in nature, return liver, stomach warp, be used for cards such as metrorrhagia, traumatic hemorrhage, spitting of blood, tumbling and swelling more.The Radix Notoginseng master contains arasaponin, flavonoid glycoside etc., has hemostasis, an effect of invigorating blood circulation, can anticoagulant, and blood viscosity is reduced.The traditional Chinese medical science thinks that " blood stasis does not remove then escape of blood from meridian, and hemorrhage can not ending.Therefore " hemorrhage to be had concurrently the stasis of blood person that stagnates particularly suitable.
15. Cornu Cervi Degelatinatum: this product is that Cornu Cervi removes gelationus hornblock.Has the kidney warming yang deficiency, anastaltic effect.Be used for deficiency of spleen-YANG and kidneyYANG, lack of appetite and vomiting, leucorrhea, bleeding not during menses etc.
16. Herba Leonuri: this product is a labiate.Has promoting blood flow to regulate menstruation, the effect of inducing diuresis to remove edema.The acrid in the mouth hardship, cool in nature.Return liver, pericardium channel.Herba Leonuri is a blood-activating and menstruation-regulating medicinal, and Compendium of Material Medica claims Herba Leonuri " removing blood stasis of invigorating blood circulation, the regulating menstruation detoxifcation is controlled the vaginal bleeding during pregnancy dystocia, placenta retention ", and the women often fries in shallow oil soup with Herba Leonuri and take puerperal.
17. Yunnan Caulis Spatholobi cream: this product is the dried cream of Yunnan Caulis Spatholobi through being processed into.Have and enrich blood, invigorate blood circulation, the effect of regulating menstruation.Be used for blood deficiency, numb hand and foot, menoxenia.
18. Oletum Trogopterori: this product is the dry feces of the animal trogopterus xanthipes Milne-Edwards Trogopterusxanthipes Milne-Edwards of Chordata Mammalia flying squirrel section.Have and invigorate blood circulation, blood stasis dispelling, analgesic effect.
19. the Rhizoma Atractylodis Macrocephalae: this product is a feverfew.Have invigorating the spleen and benefiting QI, the dampness diuretic, antiabortive, the antisudorific effect, bitter in the mouth, sweet, warm in nature.Return the taste warp.The purpose of Rhizoma Atractylodis Macrocephalae (parched with earth) strengthens the effect of invigorating the spleen to arrest diarrhea.
20. Fructus Leonuri: this product is a labiate.Has promoting blood flow to regulate menstruation, the effect of liver heat removing and eyesight improving.
21. Rhizoma Cyperi: this product is a sedge.Have promoting QI circulation for relieving depression, the effect of menstruction regulating and pain relieving, acrid in the mouth, little hardship, little sweet, property is flat, returns liver, spleen, tri-jiao channel.Can specially go into Liver Channel after the Rhizoma Cyperi vinegar system, strengthen dispersing the depressed liver-QI for alleviating pain, and can removing food stagnancyization stagnate, Rhizoma Cyperi pharmacological action in this product mainly shows the effect to the uterus, estrogen-like effects and analgesia refrigeration function.Rhizoma Cyperi is gynecological's common drug, and Li Shizhen (1518-1593 A.D.) claims that this product is " Directorate-General DG of disorder of QI, the chief commander of gynecological ", can control " woman uterine bleeding leukorrhagia, menoxenia.Abdominal carbuncle during pregnancy all kinds of diseases and ailments in puerperal.”
22. Radix Bupleuri: this product is a samphire.Have reconciling superficies and interior, soothing the liver, the effect of yang invigorating, bitter in the mouth, cold nature.Return liver, gallbladder meridian.Saikoside and volatile oil are the active main component of Radix Bupleuri.Radix Bupleuri mainly has refrigeration function in this product and fat is imitated metabolism regulating liver-QI, cholic influence.Recent studies proves that the Radix Bupleuri decoct all has the effect of tangible refrigeration function and dispersing the stagnated live-QI to relieve the stagnation of QI.
23. the Radix Linderae: this product is a canella.Have promoting the circulation of QI to relieve pain, the effect of dispelling cold and warming the kidney.Experiment in vitro proves that the Radix Linderae can obviously shorten the plasma in rabbit recalcification time, promotes blood clotting.
24. Rhizoma Corydalis: this product is a bloodroot.Being the key medicine of blood circulation promoting and blood stasis dispelling, regulating QI to relieve pain, is one of tcm clinical practice common drug.
25. Fructus Amomi: this product is a zingiberaceous plant.Have promoting the circulation of QI to relieve pain, spleen invigorating relieving distension, the effect of antiabortive preventing or arresting vomiting.Fructus Amomi is warm in nature, acrid in the mouth.Return spleen, stomach warp.The pharmacological action of Fructus Amomi mainly shows obviously anticoagulant, antiulcer, analgesia.
26. the Cortex Eucommiae: this product is the Eucommiaceae plant.But invigorating the liver and kidney, bone and muscle strengthening, antiabortive.Be used for lumbago due to renal deficiency, blood leaking in gestation, frequent fetal movement.
27. Rhizoma Zingiberis: this product is a zingiberaceous plant.Warming spleen and stomach for dispelling cold, recuperating depleted YANG is promoted blood circulation.
28. Herba Asari: this product is an aristolochiaceae plant.Effect with expelling wind and cold.Effects such as the calmness of Herba Asari, analgesia, heart tonifying, blood vessel dilating and the metabolism of raising saccharifying enzyme are the pharmacological basis of its expelling wind and cold.
29. Radix Cyathulae: this product is an amaranthaceous plant.Has expelling wind and removing dampness, the effect that restores menstrual flow and invigorates blood circulation.
30. Cortex Cinnamomi: this product is a canella.It is supporing yang to have the fire of benefit, let the fire back to its origin, and dispersing cold for relieving pain, the effect of promoting blood circulation to remove obstruction in the collateral, acrid in the mouth, sweet, extremely hot in nature is returned kidney, spleen, the heart, Liver Channel.In Chinese medicine, the effect that Cortex Cinnamomi is alleviated limbs pain can be used for explaining with its blood vessel dilating, so Cortex Cinnamomi water extract and volatile oil all can be treated dysmenorrhea.
31. Radix Dipsaci: this product is the Dipsacaceae plant.Have invigorating the liver and kidney, bone and muscle strengthening, continuous folding is hindered, and ends the effect of metrorrhagia.
32. Semen sojae atricolor: this product is the black seed of legume soybean.Its darkish complexion, so shape such as Semen sojae atricolor are name.Have the diuretic therapeutic method to keep the adverse QI flowing downwards, the effect of the kidney invigorating is moisturized in the detoxifcation of dispeling the wind, and sweet in the mouth, flat is gone into kidney, spleen two warps, and this product is sweet can tonification, goes into kidney channel, can the kidney invigorating void; Being rich in oils and fats again can moisturize.So be applicable to diseases such as treatment enuresis due to deficiency of the kidney, the dry night sweat of kidney.
33. Oryza glutinosa: this product is the seed of grass Oryza sativa L. var. glutinosa Matsum..Invigorating the spleen and replenishing QI, be good for the stomach and in, be usually used in treating the card of weakness.
34. maltose: this product is the sugar that grains such as rice, Fructus Hordei Vulgaris, Semen Tritici aestivi are made through the fermentation saccharifying.Has nourishing in the clinical practice, QI invigorating tonify deficiency, effects such as slow middle pain relieving.
Above-mentioned 30 kinds of traditional Chinese medicines prescriptions as outside the principal agent, use gynecological's medicinal herbs most in use such as Radix Angelicae Sinensis, Radix Rehmanniae Preparata divided by kidney-Yang invigorating, the Radix Ginseng that fills blood, Cornu Cervi Pantotrichum in a large number.Radix Angelicae Sinensis, " drawing China's son book on Chinese herbal medicine " record, this product " is controlled a wind cutting, all blood, is mended all labor, break stagnant blood, support fresh blood ", is the first-selected good medicine that the successive dynasties doctor treats gynaecopathia; Radix Rehmanniae Preparata be " panacea " by " medicine justice " honor, can grow seminal fluid, benefiting essence-blood, the withered insufficiency of blood in all Tianjin, behind sweating in critical stage consumption of essence and the profuse bleeding, puerperal disease such as blood deficiency, agent is thrown frequently greatly, its merit is very big.Song dynasty office side " SIWU TANG " is that enrich blood in successive dynasties heavy prescription, regulating menstruation wanted the side, the just first-elected Radix Angelicae Sinensis of its prescription, Radix Rehmanniae Preparata two medicines.Use above-mentioned four flavors except that a large amount of in the side in addition, also help with Radix Notoginseng, Oletum Trogopterori, the Radix Paeoniae Alba, Rhizoma Corydalis, in order to eliminating stasis to stop pain, hemostasis, easing the affected liver; Herba Leonuri, Flos Carthami, Radix Scutellariae, Fructus Leonuri, Spatholobi Paste, Rhizoma Chuanxiong and Stigma Croci promoting blood flow to regulate menstruation, antiabortive; Poria, the Rhizoma Atractylodis Macrocephalae, Cortex Cinnamomi and Fructus Amomi the spleen strengthening and damp drying; The Radix Linderae, Rhizoma Cyperi are regulated the flow of vital energy, soothing liver-QI, bring down a fever; Other has the Cornu Cervi Degelatinatum of YIN nourishing, kidney tonifying, blood pressure lowering and Colla Corii Asini etc., tonify without causing stagnation, and treating YANG within YIN, negative and positive are all mended, and reach equilibrated combined therapy effect.
The present invention treats the Chinese patent medicine of gynaecopathia, and described Chinese patent medicine is according to comprising that the method for following each processing step obtains:
(1). concoct each medicine respectively
With Cornu Cervi Pantotrichum, the Radix Paeoniae Alba, Radix Angelicae Sinensis, Radix Scutellariae processed with wine; Rhizoma Atractylodis Macrocephalae parching with earth, Rhizoma Cyperi, Rhizoma Corydalis, Oletum Trogopterori vinegar system; Rhizoma Chuanxiong is processed by Rhizoma Zingiberis Recens; The Radix Glycyrrhizae processed with honey; The Cortex Eucommiae, Rhizoma Zingiberis parch to black; Remaining medical material is made back cutting, drying only;
(2). expect in the middle of preparing each respectively
-Yunnan Caulis Spatholobi decocts with water three times, filters, and filtrate is condensed into thick paste, and oven dry is pulverized, 60～120 orders that sieve, and it is standby to get Yunnan Caulis Spatholobi cream powder;
-Oryza glutinosa is cleaned, cook, oven dry is pulverized, 60～120 orders that sieve, it is standby to get ripe glutinous rice flour;
-get Radix Ginseng, Radix Notoginseng, Radix Paeoniae Alba (processed with wine) with 50～90% ethanol extractions 2～3 times, filter, filtrate recycling ethanol, clear paste A is standby;
-the Rhizoma Atractylodis Macrocephalae (parched) that fetches earth, Rhizoma Cyperi (processed with vinegar), Radix Bupleuri, Cortex Cinnamomi, Fructus Amomi, Herba Asari, Radix Angelicae Sinensis (processed with wine), Rhizoma Zingiberis Recens are processed Rhizoma Chuanxiong and extract volatile oil, and volatile oil and the surplus medicinal residues of institute are standby respectively;
-get medicinal residues behind Radix Cyathulae, Radix Glycyrrhizae Preparata and the said extracted volatile oil of Flos Carthami, Fructus Lycii, Herba Leonuri, Faeces Trogopteri (processed with vinegar), Poria, Fructus Leonuri, the Radix Linderae, Rhizoma Corydalis (processed with vinegar), Radix Scutellariae (processed with wine), recipe quantity 60%～80% of Radix Rehmanniae Preparata, recipe quantity 80.6%～99.6% with water extraction 2～3 times, filter, filtrate concentrates or passes through resin absorption, eluting, reconcentration, it is standby to get clear paste B;
(3). the Radix Cyathulae of the recipe quantity 20%～40% of remaining part and Flos Carthami and Radix Dipsaci, the Semen sojae atricolor of recipe quantity 0.4%～19.4% are decocted with water three times, collecting decoction, filter, filtrate is concentrated into relative density 1.20～1.30, add Yunnan Caulis Spatholobi cream powder, ripe glutinous rice flour and maltose, fully mix thoroughly, drying, the C that gets dry extract is standby;
(4). get Colla Corii Asini, charred Cortex Eucommiae, carbonized Rhizoma Zingiberis, Cornu Cervi Pantotrichum (processed with wine), Cornu Cervi Degelatinatum, Stigma Croci and dried cream C and be ground into powder or be broken into micropowder through superfine powder, standby;
(5). with the powder of above-mentioned steps (4) or micropowder and clear paste A, clear paste B mix homogeneously, crushed after being dried is powder D;
(6). add volatile oil;
(7). make capsule, tablet, granule, soft capsule medicine with distinct methods.
Described extraction volatile oil adopts steam distillation, or supercritical extraction, or milling process.
The preparation method of described capsule is: in above-mentioned steps (7)
-powder D and volatile oil mix homogeneously take a morsel;
-adding all the other powder D and filler mix homogeneously again, its ratio is: powder D 96～99.5%, filler 0.5～4.0%, filler are selected micropowder silica gel or starch or microcrystalline Cellulose for use;
-be filled into capsule, promptly get the capsule medicine.
The preparation method of described tablet is: in above-mentioned steps (7)
-adding disintegrating agent 0.1～10% mix homogeneously in powder D;
-add binding agent 0.5～5.0% with the compound moistening;
-wet feed is made granule, drying;
-with the beta-cyclodextrin inclusion compound volatile oil of 4 times of amounts of volatile oil, sneak into then in the granule, add lubricant 0.5～2.0% mix homogeneously;
-with tablet machine with the hybrid particles tablet forming, promptly get the tablet medicine.
The weight percent proportioning of powder D and adjuvant is: powder D83%～98.9%, disintegrating agent 0.1～10%, binding agent 0.5～5.0%, lubricant 0.5～2.0%.Described disintegrating agent is selected carboxymethyl starch sodium or low-substituted hydroxypropyl cellulose or methylcellulose for use; Described binding agent is selected ethanol or starch slurry or polyvinylpyrrolidone for use; Described lubricant adopts magnesium stearate or stearic acid or Pulvis Talci.
The preparation method of described granule is: in above-mentioned steps (7)
-adding filler 10～30% mix homogeneously in powder D65～89.5%;
-add binding agent 0.5～5.0% with the compound moistening;
-wet feed is made granule, drying;
-with calcium sulfate or the starch or the micropowder silica gel absorption volatile oil of 4 times of amounts of volatile oil, sneak into then in the granule, promptly get the granule medicine.
The weight percent proportioning of powder D and adjuvant is: powder D 65%～89.5%, filler 10～30%, binding agent 0.5～5.0%.Described filler is selected sucrose or dextrin or lactose for use; Described binding agent is selected ethanol or starch slurry or polyvinylpyrrolidone for use.
Described soft capsule preparation method is: in above-mentioned steps (7)
-with the beta-cyclodextrin inclusion compound volatile oil of 4 times of amounts of volatile oil, sneak into then among the powder D;
-adding the vegetable oil of above-mentioned compound 15% again, pill promptly gets the soft capsule medicine.
[beneficial effect]
The present invention is owing to pay attention to the coordination of Chinese medicine preparation, according to the theory of Chinese medical science scientific composition, having overcome existing Amino-Cerv effect has the drawback that lays particular stress on, and takes into account clearing away heat-damp and promoting diuresis, treating blood disorders regulating menstruation and tonification and sets upright a plurality of effects, at treatment gynecological inflammation, asthenia of qi and blood, the tripartite mask for the treatment of blood disorders regulating menstruation better curative effect is arranged.
The present invention presses the Chinese medical theory prescription according to the character of each medical material in the prescription, extracts Synergistic respectively.Medical material significantly reduces invalid element after extracting purification, harmful substance such as persticide residue, heavy metal amount etc. obviously reduce.
The modern pharmacology pharmacodynamic study shows: this medicine has strengthening by means of tonics, adjusts sexual cycle, increases estrogen (E
2) level, promote uterus and development of ovary effect; Whole blood viscosity rising and erythrocyte aggregation index rising to " syndrome of blood stasis " mice have significant reduction effect; Inhibited to normal rat at the body uterine activity; The rat that pituitrin (containing oxytocin) is caused also has the antagonism inhibitory action at the spastic contraction movement of body uteri excitation; Have sedation, analgesic activity, anastalsis and antiinflammatory action simultaneously.Medicine of the present invention is made tablet, capsule, granule, soft capsule etc., can satisfy different patients' treatment needs.Each drug form has different characteristics: capsule is easy to carry, can cover the bad smell of medicine, and the adjuvant addition is few, and dose is little, and pesticide residues and content of beary metal are low, and the product easy disintegrating absorbs; Tablet quality is stable, removes impurity in a large number, and active ingredient is concentrated, the bioavailability height, and the adding adjuvant can better improve air, moisture influences it; Granule is little to GI irritation, and drug loading is big, and mouthfeel is good, is beneficial to female patient and accepts; Volatile oil composition in the fine reservation preparation of soft capsule, and cover the bad smell of medicine.
Medicine of the present invention has nourishing qi and blood, the function of regulating menstruation Shu Yu.For menoxenia, abdominal pain during menstruation, metrostaxis, leucorrhea with red and white discharge, anemia is weak, the bruise blood prostration, puerperal all void, diseases such as osteopyrexia and fever have reasonable therapeutic effect.
[specific embodiment]
Embodiment 1: the preparation of capsule
135 parts of 27 parts of Radix Rehmanniae Preparata of 27 parts of Cornu Cervi Pantotrichums of Radix Ginseng
36.67 parts on 4 parts of Flos Carthamis of 135 parts of Stigma Crocis of Radix Angelicae Sinensis
67.5 parts of 27 parts of Cornu Cervi Degelatinatums of 33.75 parts of Colla Corii Asini of Radix Notoginseng
6.75 parts of 40.5 parts of Herba Leonuris of 40.5 parts of Fructus Lycii of the Radix Paeoniae Alba
5.5 parts in 6.75 parts of Poria of 7.38 parts of Oletum Trogopteroris of Yunnan Caulis Spatholobi cream powder
4 parts of 6.75 parts of Rhizoma Chuanxiongs of 40.5 parts of Fructus Leonuris of the Rhizoma Atractylodis Macrocephalae
4 parts of 5.5 parts of Radixs Linderae of 6.75 parts of Radix Bupleuri of Rhizoma Cyperi
2.75 parts of 2.75 parts of Fructus Amomis of 6.75 parts of Radix Scutellariaes of Rhizoma Corydalis
2 parts of 5.5 parts of Herba Asaris of 5.5 portions of Rhizoma Zingiberiss of the Cortex Eucommiae
6.75 parts in 2.75 portions of Radix Glycyrrhizaes of 6 portions of Cortex Cinnamomis of Radix Cyathulae
14.76 parts in 0.42 part of Oryza glutinosa of 1.79 parts of Semen sojae atricolors of Radix Dipsaci
10.1 parts of maltoses
Take by weighing raw materials of traditional Chinese medicinal materials according to above-mentioned consumption.(1). with Cornu Cervi Pantotrichum, the Radix Paeoniae Alba, Radix Angelicae Sinensis, Radix Scutellariae processed with wine; Rhizoma Atractylodis Macrocephalae parching with earth, Rhizoma Cyperi, Rhizoma Corydalis, Oletum Trogopterori vinegar system; Rhizoma Chuanxiong is processed by Rhizoma Zingiberis Recens; The Radix Glycyrrhizae processed with honey; The Cortex Eucommiae, Rhizoma Zingiberis parch to black; Remaining medical material is made back cutting, drying only.(2). Yunnan Caulis Spatholobi is decocted with water three times, each 2 hours, filter, filtrate is condensed into thick paste, and oven dry is pulverized, and 100 orders that sieve are standby; Oryza glutinosa is cleaned, cooked, oven dry is pulverized, and 100 orders that sieve are standby; Get Radix Ginseng, Radix Notoginseng, Radix Paeoniae Alba (processed with wine) and be ground into coarse powder, mixing is according to the percolation under fluid extract and the extractum item (" appendix of Chinese pharmacopoeia version in 2005), make solvent with 70% ethanol, flooded percolation 24 hours, collect percolate, recovery ethanol is not to there being the alcohol flavor, and it is standby to get clear paste A; Fetch earth Rhizoma Atractylodis Macrocephalae (parched), Rhizoma Cyperi (processed with vinegar), Radix Bupleuri, Cortex Cinnamomi, Fructus Amomi, Herba Asari, Radix Angelicae Sinensis (processed with wine), Rhizoma Zingiberis Recens processed Rhizoma Chuanxiong water vapour distillation volatile oil, and the aqueous solution after distillation device is in addition collected, and volatile oil and medicinal residues are standby respectively; Get above-mentioned medicinal residues, Radix Rehmanniae Preparata, Flos Carthami (dosage 99.5%), Fructus Lycii, Herba Leonuri, Faeces Trogopteri (processed with vinegar), Poria, Fructus Leonuri, the Radix Linderae, Rhizoma Corydalis (processed with vinegar), Radix Scutellariae (processed with wine), Radix Cyathulae (dosage 66.6%), the Radix Glycyrrhizae Preparata medical material decocts with water secondary, each 1.5 hours, filter, filtrate directly concentrates, and it is standby to get clear paste B.(3). the Radix Cyathulae of remaining part (dosage 33.4%) and Flos Carthami (dosage 0.5%) is decocted with water three times with Radix Dipsaci, Semen sojae atricolor, each 2 hours, collecting decoction, filter, filtrate is concentrated into relative density 1.20～1.30 (80 ℃), adds Yunnan Caulis Spatholobi cream powder, ripe glutinous rice flour and maltose, fully mixes thoroughly, vacuum drying, the C that gets dry extract is standby.(4). getting Colla Corii Asini, charred Cortex Eucommiae, carbonized Rhizoma Zingiberis, Cornu Cervi Pantotrichum (processed with wine), Cornu Cervi Degelatinatum, Stigma Croci and dried cream C, to be ground into powder standby.(5). with above-mentioned (4) said powder and clear paste A, clear paste B mix homogeneously, pulverize behind the vacuum drying and be powder D.(6). get 4% powder D and volatile oil mix homogeneously.
(7). add the micropowder silica gel mix homogeneously of remaining powder D and 2.0% again; Be filled into capsule, promptly get the capsule medicine.
Embodiment 2: the preparation of tablet
1100 parts of 220 parts of Radix Rehmanniae Preparata of 220 parts of Cornu Cervi Pantotrichums of Radix Ginseng
300 parts on 32 parts of Flos Carthamis of 1100 parts of Stigma Crocis of Radix Angelicae Sinensis
600 parts of 220 parts of Cornu Cervi Degelatinatums of 300 parts of Colla Corii Asini of Radix Notoginseng
60 parts of 330 parts of Herba Leonuri of 330 parts of Fructus Lycii of the Radix Paeoniae Alba
44 parts in 60 parts of Poria of 60 parts of Oletum Trogopteroris of Yunnan Caulis Spatholobi cream powder
40 parts of 60 parts of Rhizoma Chuanxiongs of 330 parts of Fructus Leonuris of the Rhizoma Atractylodis Macrocephalae
40 parts of 44 parts of Radixs Linderae of 60 parts of Radix Bupleuri of Rhizoma Cyperi
22 parts of 22 parts of Fructus Amomis of 60 parts of Radix Scutellariaes of Rhizoma Corydalis
20 parts of 44 parts of Herba Asaris of 44 portions of Rhizoma Zingiberiss of the Cortex Eucommiae
60 parts in 22 portions of Radix Glycyrrhizaes of 50 portions of Cortex Cinnamomis of Radix Cyathulae
140 parts in 4 parts of Oryza glutinosa of 20 parts of Semen sojae atricolors of Radix Dipsaci
100 parts of maltoses
Take by weighing raw materials of traditional Chinese medicinal materials according to above-mentioned consumption.(1). with Cornu Cervi Pantotrichum, the Radix Paeoniae Alba, Radix Angelicae Sinensis, Radix Scutellariae processed with wine; Rhizoma Atractylodis Macrocephalae parching with earth, Rhizoma Cyperi, Rhizoma Corydalis, Oletum Trogopterori vinegar system; Rhizoma Chuanxiong is processed by Rhizoma Zingiberis Recens; The Radix Glycyrrhizae processed with honey; The Cortex Eucommiae, Rhizoma Zingiberis parch to black; Remaining medical material is made back cutting, drying only.(2). Yunnan Caulis Spatholobi is decocted with water three times, each 1.5 hours, filter, filtrate is condensed into thick paste, and oven dry is pulverized, and 80 orders that sieve are standby; Oryza glutinosa is cleaned, cooked, oven dry is pulverized, and 80 orders that sieve are standby; Get Radix Ginseng, Radix Notoginseng, Radix Paeoniae Alba (processed with wine) and be ground into coarse powder, mixing is made solvent with 50% ethanol, reflux, extract, 2 times, each 2 hours, collect extracting solution, reclaim ethanol to there not being the alcohol flavor, clear paste A is standby; Fetch earth Rhizoma Atractylodis Macrocephalae (parched), Rhizoma Cyperi (processed with vinegar), Radix Bupleuri, Cortex Cinnamomi, Fructus Amomi, Herba Asari, Radix Angelicae Sinensis (processed with wine), Rhizoma Zingiberis Recens processed the Rhizoma Chuanxiong supercritical extraction and extracted volatile oil, and volatile oil and medicinal residues are standby respectively; Get above-mentioned medicinal residues, Radix Rehmanniae Preparata, Flos Carthami (dosage 80.6%), Fructus Lycii, Herba Leonuri, Faeces Trogopteri (processed with vinegar), Poria, Fructus Leonuri, the Radix Linderae, Rhizoma Corydalis (processed with vinegar), Radix Scutellariae (processed with wine), Radix Cyathulae (dosage 60%), the Radix Glycyrrhizae Preparata medical material decocts with water three times, each 1.5 hours, filter, filtrate is through adsorbent resin absorption, adopt 50% ethanol elution, eluent concentrates, and it is standby to get clear paste B.(3). the Radix Cyathulae of remaining part (dosage 40%) and Flos Carthami (dosage 19.4%) is decocted with water three times with Radix Dipsaci, Semen sojae atricolor, each 3 hours, collecting decoction, filter, filtrate is concentrated into about 1.25 (80 ℃) of relative density, adds Yunnan Caulis Spatholobi cream powder, ripe glutinous rice flour and maltose, fully mixes thoroughly, hot air drying, the C that gets dry extract is standby.(4). getting Colla Corii Asini, charred Cortex Eucommiae, carbonized Rhizoma Zingiberis, Cornu Cervi Pantotrichum (processed with wine), Cornu Cervi Degelatinatum, Stigma Croci and dried cream C superfine powder, to be broken into micropowder standby.(5). with above-mentioned (4) said micropowder and clear paste A, clear paste B mix homogeneously, pulverize behind the vacuum drying and be powder D.
(6). in powder D, add 10% carboxymethyl starch sodium mix homogeneously.(7). the ethanol of adding 5% is with the compound moistening; Wet feed is made granule, drying for standby.(8). with the beta-cyclodextrin inclusion compound volatile oil of 4 times of amounts of volatile oil, sneak into then in the granule, add 0.5% magnesium stearate, with the hybrid particles tablet forming, promptly get the tablet medicine with tablet machine.
Embodiment 3: the preparation of granule
540 parts of 108 parts of Radix Rehmanniae Preparata of 108 parts of Cornu Cervi Pantotrichums of Radix Ginseng
146.68 parts on 16 parts of Flos Carthamis of 540 parts of Stigma Crocis of Radix Angelicae Sinensis
270 parts of 108 parts of Cornu Cervi Degelatinatums of 135 parts of Colla Corii Asini of Radix Notoginseng
27 parts of 162 parts of Herba Leonuris of 162 parts of Fructus Lycii of the Radix Paeoniae Alba
22 parts in 27 parts of Poria of 29.53 parts of Oletum Trogopteroris of Yunnan Caulis Spatholobi cream powder
16 parts of 27 parts of Rhizoma Chuanxiongs of 162 parts of Fructus Leonuris of the Rhizoma Atractylodis Macrocephalae
16 parts of 22 parts of Radixs Linderae of 27 parts of Radix Bupleuri of Rhizoma Cyperi
11 parts of 11 parts of Fructus Amomis of 27 parts of Radix Scutellariaes of Rhizoma Corydalis
8 parts of 22 parts of Herba Asaris of 22 portions of Rhizoma Zingiberiss of the Cortex Eucommiae
27 parts in 11 portions of Radix Glycyrrhizaes of 24.03 portions of Cortex Cinnamomis of Radix Cyathulae
59.06 parts in 1.69 parts of Oryza glutinosa of 7.16 parts of Semen sojae atricolors of Radix Dipsaci
40.5 parts of maltoses
Take by weighing raw materials of traditional Chinese medicinal materials according to above-mentioned consumption.(1). with Cornu Cervi Pantotrichum, the Radix Paeoniae Alba, Radix Angelicae Sinensis, Radix Scutellariae processed with wine; Rhizoma Atractylodis Macrocephalae parching with earth, Rhizoma Cyperi, Rhizoma Corydalis, Oletum Trogopterori vinegar system; Rhizoma Chuanxiong is processed by Rhizoma Zingiberis Recens; The Radix Glycyrrhizae processed with honey; The Cortex Eucommiae, Rhizoma Zingiberis parch to black; Remaining medical material is made back cutting, drying only.(2). Yunnan Caulis Spatholobi is decocted with water three times, each 3 hours, filter, filtrate is condensed into thick paste, and oven dry is pulverized, and 120 orders that sieve are standby; Oryza glutinosa is cleaned, cooked, oven dry is pulverized, and 120 orders that sieve are standby; Get Radix Ginseng, Radix Notoginseng, Radix Paeoniae Alba (processed with wine) and be ground into coarse powder, mixing is made solvent with 90% ethanol, floods 7 days, collects impregnation liquid, reclaims ethanol to there not being the alcohol flavor, clear paste A is standby; Fetch earth Rhizoma Atractylodis Macrocephalae (parched), Rhizoma Cyperi (processed with vinegar), Radix Bupleuri, Cortex Cinnamomi, Fructus Amomi, Herba Asari, Radix Angelicae Sinensis (processed with wine), Rhizoma Zingiberis Recens processed the Rhizoma Chuanxiong squeezing and extracted volatile oil, and volatile oil and medicinal residues are standby respectively; Get above-mentioned medicinal residues, Radix Rehmanniae Preparata, Flos Carthami (dosage 99.6%), Fructus Lycii, Herba Leonuri, Faeces Trogopteri (processed with vinegar), Poria, Fructus Leonuri, the Radix Linderae, Rhizoma Corydalis (processed with vinegar), Radix Scutellariae (processed with wine), Radix Cyathulae (dosage 70%), the Radix Glycyrrhizae Preparata medical material decocts with water three times, each 1.5 hours, filter, filtrate directly concentrates, and it is standby to get clear paste B.(3). the Radix Cyathulae of remaining part (dosage 30%) and Flos Carthami (dosage 0.4%) is decocted with water three times with Radix Dipsaci, Semen sojae atricolor, each 3 hours, collecting decoction, filter, filtrate is concentrated into relative density 1.20～1.30 (80 ℃), adds Yunnan Caulis Spatholobi cream powder, ripe glutinous rice flour and maltose, fully mixes thoroughly, airpillow-dry, the C that gets dry extract is standby.(4). get Colla Corii Asini, charred Cortex Eucommiae, carbonized Rhizoma Zingiberis, Cornu Cervi Pantotrichum (processed with wine), Cornu Cervi Degelatinatum, Stigma Croci and dried cream C superfine powder and be broken into micropowder, standby.(5). with above-mentioned (4) said micropowder and clear paste A, clear paste B mix homogeneously, pulverize behind the vacuum drying and be powder D.(6). with calcium sulfate or the micropowder silica gel or the starch absorption volatile oil of 4 times of amounts, standby.(7). in powder D, add 30% sucrose or 30% dextrin mix homogeneously; The starch slurry of adding 5.0% is with the compound moistening; Wet feed is made granule, drying.(8). the volatile oil after will absorbing mixes with granule, promptly gets the granule medicine.
Embodiment 4: the preparation method of soft capsule
540 parts of 108 parts of Radix Rehmanniae Preparata of 108 parts of Cornu Cervi Pantotrichums of Radix Ginseng
146.68 parts on 16 parts of Flos Carthamis of 540 parts of Stigma Crocis of Radix Angelicae Sinensis
270 parts of 108 parts of Cornu Cervi Degelatinatums of 135 parts of Colla Corii Asini of Radix Notoginseng
27 parts of 162 parts of Herba Leonuris of 162 parts of Fructus Lycii of the Radix Paeoniae Alba
22 parts in 27 parts of Poria of 29.53 parts of Oletum Trogopteroris of Yunnan Caulis Spatholobi cream powder
16 parts of 27 parts of Rhizoma Chuanxiongs of 162 parts of Fructus Leonuris of the Rhizoma Atractylodis Macrocephalae
16 parts of 22 parts of Radixs Linderae of 27 parts of Radix Bupleuri of Rhizoma Cyperi
11 parts of 11 parts of Fructus Amomis of 27 parts of Radix Scutellariaes of Rhizoma Corydalis
8 parts of 22 parts of Herba Asaris of 22 portions of Rhizoma Zingiberiss of the Cortex Eucommiae
27 parts in 11 portions of Radix Glycyrrhizaes of 24.03 portions of Cortex Cinnamomis of Radix Cyathulae
59.06 parts in 1.69 parts of Oryza glutinosa of 7.16 parts of Semen sojae atricolors of Radix Dipsaci
40.5 parts of maltoses
Take by weighing raw materials of traditional Chinese medicinal materials according to above-mentioned consumption.(1). with Cornu Cervi Pantotrichum, the Radix Paeoniae Alba, Radix Angelicae Sinensis, Radix Scutellariae processed with wine; Rhizoma Atractylodis Macrocephalae parching with earth, Rhizoma Cyperi, Rhizoma Corydalis, Oletum Trogopterori vinegar system; Rhizoma Chuanxiong is processed by Rhizoma Zingiberis Recens; The Radix Glycyrrhizae processed with honey; The Cortex Eucommiae, Rhizoma Zingiberis parch to black; Remaining medical material is made back cutting, drying only.(2). Yunnan Caulis Spatholobi is decocted with water three times, filter, filtrate is condensed into thick paste, and oven dry is pulverized, and 120 orders that sieve are standby; Oryza glutinosa is cleaned, cooked, oven dry is pulverized, and 120 orders that sieve are standby; Get Radix Ginseng, Radix Notoginseng, Radix Paeoniae Alba (processed with wine) and be ground into coarse powder, mixing is made solvent with 75% ethanol, reflux, extract, 3 times, each 2 hours, collect extracting solution, reclaim ethanol to there not being the alcohol flavor, clear paste A is standby; Fetch earth Rhizoma Atractylodis Macrocephalae (parched), Rhizoma Cyperi (processed with vinegar), Radix Bupleuri, Cortex Cinnamomi, Fructus Amomi, Herba Asari, Radix Angelicae Sinensis (processed with wine), Rhizoma Zingiberis Recens processed Rhizoma Chuanxiong water vapour distillation volatile oil, and the aqueous solution after distillation device is in addition collected, and volatile oil and medicinal residues are standby respectively; Get above-mentioned medicinal residues, Radix Rehmanniae Preparata, Flos Carthami (dosage 90%), Fructus Lycii, Herba Leonuri, Faeces Trogopteri (processed with vinegar), Poria, Fructus Leonuri, the Radix Linderae, Rhizoma Corydalis (processed with vinegar), Radix Scutellariae (processed with wine), Radix Cyathulae (dosage 65%), the Radix Glycyrrhizae Preparata medical material decocts with water secondary, each 1.5 hours, filter, filtrate concentrates, and it is standby to get clear paste B.(3). the Radix Cyathulae of remaining part (dosage 35%) and Flos Carthami (dosage 10%) is decocted with water three times with Radix Dipsaci, Semen sojae atricolor, each 1 hour, collecting decoction, filter, filtrate is concentrated into relative density 1.20～1.30 (80 ℃), adds Yunnan Caulis Spatholobi cream powder, ripe glutinous rice flour and maltose, fully mixes thoroughly, vacuum drying, the C that gets dry extract is standby.(4). getting Colla Corii Asini, charred Cortex Eucommiae, carbonized Rhizoma Zingiberis, Cornu Cervi Pantotrichum (processed with wine), Cornu Cervi Degelatinatum, Stigma Croci and dried cream C, to be ground into powder standby.(5). with the powder in above-mentioned (4) and clear paste A, clear paste B mix homogeneously, pulverize behind the vacuum drying and be powder D.(6). with the beta-cyclodextrin inclusion compound volatile oil of 4 times of amounts of volatile oil, sneak into then among the powder D; (7). the vegetable oil of adding 15% in above-mentioned compound, pill promptly gets the soft capsule medicine.
Above example does not limit the scope of the invention, scope of the present invention is determined by the technical scheme of claim record, the concrete application of technical scheme is flexibly, any product and correlation technique that utilizes technical scheme of the present invention or its prompting preparation, all within the scope of the invention.
Below example is further set forth beneficial effect of the present invention by experiment, and these experimental examples have comprised that the effect experiment of medicine of the present invention and composition detect.
Experimental example 1: adjust the sexual cycle effect
The sexual cycle test of getting about body weight 35g is 40 of regular sexual maturity female mices, arrange in pairs or groups at random by body weight and to be divided into 4 groups, cause sexual cycle imbalance model, irritate stomach respectively for every group, NVJIN WAN (positive control medicine) group: 2.5g (ball is heavy)/kg, Capsules group 1.5 crude drugs of the present invention/kg, granule group 1.5 crude drugs of the present invention/kg, model control group gives with the volume distilled water, every day 1 time, continuous 14 days, pull out eyeball in 24 hours after the last administration and get blood, anticoagulant heparin, separated plasma detects estradiol (E2) content in the blood plasma with radio immunoassay.Experimental result (see Table 1, table 2) shows: capsule of the present invention, granule etc., after the not normal female mice successive administration of sexual cycle treated for 2 weeks (14 days), the size of animal that is in rutting period and metoestrus is significantly increased, the level of mice serum estradiol (E2) significantly increases, and has the modulability period effects.
The influence that the not normal female mice sexual cycle of table 1 pair sexual cycle changes
Annotate: medication group and model control group are relatively carried out x with rutting period (containing metoestrus) and non-estrus (diestrus and proestrus)
2Check,
*P＜0.05.
The influence of the not normal female mice serum estradiol of table 2 pair sexual cycle content
Experimental example 2: promote uterus and ovary effect of gain
Get 40 of body weight 12～15g young female mices, collocation is divided into 4 groups at random, irritate stomach respectively for every group, NVJIN WAN (positive control medicine) group: 2.5g (ball is heavy)/kg, Capsules group 1.5 crude drugs of the present invention/kg, granule group 1.5 crude drugs of the present invention/kg, model control group gives with the volume distilled water, every day 1 time, continuous 14 days, put to death mice in 24 hours after the last administration, cut open and get the uterus and ovary is weighed.Experimental result (seeing Table 3) shows: capsule of the present invention, granule etc., after 2 weeks of young female mice successive administration (14 days), have the effect of estrogen sample, and can significantly promote the growth of young female Mouse Uterus and ovary, its weight coefficient is increased.
The influence of table 3 pair young female Mouse Uterus and ovary weight coefficient
Annotate: compare with the blank group,
*P＜0.01.
Experimental example 3: suppress the uterus effect
Get 40 of body weight 180～230g female rats, be divided into 4 groups at random, fasting be can't help water 14 hours, with urethane solution 800mg/kg light anaesthesia is carried out in rat tail vein injection, open the abdominal cavity, find out uterus section (about 2cm) and be connected on the pressure transducer of BL-310 biological function experimental system, treat rat uterus movable steadily after, record administration normal uterine activity curve the last period.Then from the duodenum drug administration by injection, NVJIN WAN (positive control medicine) group 125g (ball is heavy)/kg, Capsules group 0.750g crude drug/kg of the present invention, granule group 0.750g crude drug/kg of the present invention, model control group gives with the volume normal saline, equally respectively remembers a cross-talk palace activity curve after administration in 20,40 minutes.Observation the uterus contraction frequency (inferior/min) and shrinkage amplitude (muscular tension, g).Result of the test (seeing Table 4) shows: capsule of the present invention, granule etc. have inhibitory action to normal rat at the body uterine activity, the uterine smooth muscle contraction frequency are slowed down and smooth muscle tension force (shrinkage amplitude) reduction.
Table 4 medicine of the present invention is to the influence of normal rat at the body uterine activity
Annotate: compare with the blank group (1),
*P＜0.05,
*P＜0.01;
(2) numerical value is the percentage rate that reduces than blank group in the bracket.
Experimental example 4: anti-anemia effect
The female mice of getting body weight 18～22g cuts off the most advanced and sophisticated blood-letting of Mus tail, sets up the anemia model.Content of hemoglobin value size matching according to anemia mice is divided into 5 groups, 10 every group.Irritate stomach respectively for every group, NVJIN WAN (positive control medicine) group 2.5g (ball is heavy)/kg, Capsules group 1.5g crude drug/kg of the present invention, granule group 1.5 crude drugs of the present invention/kg, model control group gives with the volume distilled water, every day 1 time, successive administration 7 days.Get mouse orbit venous plexus blood measuring and calculate content of hemoglobin.Experimental result (seeing Table 5) shows: gastric infusions such as capsule of the present invention, granule 7 days, the blood red egg content of the experimental anemia mice that all can raise significantly has anti-anemia effect.
The anti-anemia effect of table 5 (x ± s)
Annotate: compare before and after the same group of internal therapy,
*P＜0.05.
Experimental example 5: the effect of invigorating blood circulation
Get 50 of body weight 24～30g female mices, be divided into 5 groups at random, irritate stomach respectively for every group, aspirin (positive control medicine) group 20mg/kg, Capsules group 1.5 crude drugs of the present invention/kg, granule group 1.5 crude drugs of the present invention/kg, model control group gives with the volume distilled water, every day 1 time, successive administration 7 days.Experiment the 6th day morning of administration, each is organized equal subcutaneous injection epinephrine solution and causes " blood stasis " model, pulls out eyeball of mouse in 1 hour after the last administration in the 7th day to get blood, measures whole blood viscosity and erythrocyte aggregation index.Result's (seeing Table 6) shows: capsule of the present invention, granule gastric infusion 7 days raise and the erythrocyte aggregation index rising has in various degree reduction effect to the whole blood viscosity of " syndrome of blood stasis " mice.Its effect of " invigorating blood circulation " is dose-effect relationship and changes.This " invigorating blood circulation " effect is to strengthening its circulation of qi promoting, enrich blood, regulating menstruation, pain relieving and to end function such as metrorrhagia very useful.
Table 6 medicine of the present invention is to the influence of " syndrome of blood stasis " mice whole blood viscosity and erythrocyte aggregation index
Annotate: compare with the normal control group (1), ▲ ▲ P＜0.01; (2) compare with model control group,
*P＜0.05;
*P＜0.01.
(3) in the bracket be and model control group reduction percentage rate relatively.
Experimental example 6: strong effect
Gastric infusions such as capsule of the present invention, granule 7 days all can prolong the mice swimming time significantly, strengthen muscle strength, and mice is obviously prolonged rolling the time of adhering in the handful.(see Table 7, table 8)
Table 7 antifatigue effect (x ± s)
The effect of table 8 muscle strength reinforcing (x ± s)
Experimental example 7: antiinflammatory action
(1) inhibitory action of xylol induced mice auricle inflammation swelling: get 40 of body weight 18～22g female mices, be divided into 4 groups at random, irritate stomach respectively 1 time for every group, the blank group gives distilled water 0.4ml/20g body weight; Capsules group of the present invention gives 1.5g crude drug/kg; Groups of grains of the present invention gives 1.5g crude drug/kg; Prednisone acetate tablets (positive control medicine) group gives 10mg/kg.After the administration 30 minutes, evenly coat the mouse right ear two sides with microsyringe absorption dimethylbenzene 50 μ l and cause inflammation.Put to death mice after causing scorching 1 hour, cut left and right sides auricle, with the card punch of diameter 8mm respectively in the left and right sides binauricular same area lay circular auricle, precision takes by weighing two auricle weight.With about the difference (mg) of two auricle weight as inflammation swelling degree.Result's (see Table 9, table 10) shows: capsule of the present invention, granule are to mouse stomach administration 1 time, and the swelling of xylol induced mice auricle inflammation all has significant inhibitory effect, show acute exudative inflammation is had significant antiinflammatory action.
The influence of table 9 xylol induced mice auricle inflammation swelling
(2) inhibitory action that granuloma induced by implantation of cotton pellets is formed: get 40 of body weight 18～22g female mices, be divided into 4 groups at random, each group mice is used the ether light anaesthesia, under conditions for sterilization from mice skin of groin opening, 1 cotton balls of subcutaneous implantation (10mg, high heat sterilization), skin suture.Began drug treatment 7 days the same day after implanting cotton balls.The blank group gives distilled water 0.4ml/20g body weight; Capsules group of the present invention gives 1.5g crude drug/kg; Groups of grains of the present invention gives 1.5g crude drug/kg; Prednisone acetate tablets (positive control medicine) group gives 10mg/kg.Every day 1 time, continuous 7 days.After the last administration 24 hours, take off cervical vertebra and put to death mice, the careful cotton balls that takes out the band granulation tissue of dissecting is with electronic balance precision weighing granulation tissue net weight.The result shows that capsule of the present invention, the continuous gastric infusion of granule 7 days all have obvious suppression to mice cotton balls granulation tissue weight in wet base and dry weight.Demonstration has significant antiinflammatory action to the granulation hyperplasia inflammation.
The influence that table 10 pair mice granuloma induced by implantation of cotton pellets forms (x ± s)
Annotate: compare with the blank group,
*P＜0.05;
*P＜0.01.
Experimental example 8: pesticide residues and heavy metal amount (seeing Table 11)
Table 11 medicine of the present invention and NVJIN WAN pesticide residues and the contrast of heavy metal amount
Experimental example 9: disintegration (seeing Table 12):
Table 12 medicine of the present invention and NVJIN WAN contrast disintegration
| Kind | Disintegration or dissolve scattered time limit (minute) |
| NVJIN WAN | 45 minutes |
| Capsule of the present invention | 21 minutes |
| Granule of the present invention | 5 minutes |
| Tablet of the present invention | 31 minutes |
| Soft capsule of the present invention | 30 minutes |
Claims (10)
1. Chinese patent medicine for the treatment of gynaecopathia is characterized in that the raw material of making active ingredient forms by following weight proportion:
Radix Ginseng 27～220, Cornu Cervi Pantotrichum 27～220, Radix Rehmanniae Preparata 135～1100, Radix Angelicae Sinensis 135～1100, Stigma Croci 4～32, Flos Carthami 35～300, Radix Notoginseng 33～300, Colla Corii Asini 27～220, Cornu Cervi Degelatinatum 67～600, the Radix Paeoniae Alba 40～330, Fructus Lycii 40～330, Herba Leonuri 6～60, Oletum Trogopterori 6～60, Yunnan Caulis Spatholobi cream powder 7～60, Poria 5～44, the Rhizoma Atractylodis Macrocephalae 40～330, Fructus Leonuri 6～60, Rhizoma Chuanxiong 4～40, Rhizoma Cyperi 6～60, Radix Bupleuri 5～44, the Radix Linderae 4～40, Rhizoma Corydalis 6～60, Radix Scutellariae 2～22, Fructus Amomi 2～22, the Cortex Eucommiae 5～44, Rhizoma Zingiberis 5～44, Herba Asari 2～20, Radix Cyathulae 4～50, Cortex Cinnamomi 2～22, Radix Glycyrrhizae 6～60, Radix Dipsaci 1.8～20, Semen sojae atricolor 0.4～4.0, Oryza glutinosa 14～140, maltose 10～100.
2. the Chinese patent medicine of treatment gynaecopathia according to claim 1 is characterized in that the weight proportion of each raw material is:
Radix Ginseng 54～120, Cornu Cervi Pantotrichum 54～120, Radix Rehmanniae Preparata 270～560, Radix Angelicae Sinensis 270～550, Stigma Croci 8～20, Flos Carthami 70～180, Radix Notoginseng 66～150, Colla Corii Asini 54～150, Cornu Cervi Degelatinatum 134～350, the Radix Paeoniae Alba 80～180, Fructus Lycii 80～180, Herba Leonuri 12～35, Oletum Trogopterori 12～35, Yunnan Caulis Spatholobi cream powder 14～35, Poria 10～25, the Rhizoma Atractylodis Macrocephalae 80～180, Fructus Leonuri 12～30, Rhizoma Chuanxiong 8～20, Rhizoma Cyperi 12～35, Radix Bupleuri 10～25, the Radix Linderae 8～20, Rhizoma Corydalis 12～35, Radix Scutellariae 4～16, Fructus Amomi 4～16, the Cortex Eucommiae 10～25, Rhizoma Zingiberis 10～25, Herba Asari 4～12, Radix Cyathulae 8～30, Cortex Cinnamomi 4～16, Radix Glycyrrhizae 12～35, Radix Dipsaci 3.6～10, Semen sojae atricolor 0.8～1.8, Oryza glutinosa 28～80, maltose 20～50.
3. the Chinese patent medicine of treatment gynaecopathia according to claim 1 is characterized in that the weight proportion of each raw material is:
Radix Ginseng 108, Cornu Cervi Pantotrichum 108, Radix Rehmanniae Preparata 540, Radix Angelicae Sinensis 540, Stigma Croci 16, Flos Carthami 146.68, Radix Notoginseng 135, Colla Corii Asini 108, Cornu Cervi Degelatinatum 270, the Radix Paeoniae Alba 162, Fructus Lycii 162, Herba Leonuri 27, Yunnan Caulis Spatholobi cream powder 29.53, Oletum Trogopterori 27, Poria 22, the Rhizoma Atractylodis Macrocephalae 162, Fructus Leonuri 27, Rhizoma Chuanxiong 16, Rhizoma Cyperi 27, Radix Bupleuri 22, the Radix Linderae 16, Rhizoma Corydalis 27, Radix Scutellariae 11, Fructus Amomi 11, the Cortex Eucommiae 22, Rhizoma Zingiberis 22, Herba Asari 8, Radix Cyathulae 24.03, Cortex Cinnamomi 11, Radix Glycyrrhizae 27, Radix Dipsaci 7.16, Semen sojae atricolor 1.69, Oryza glutinosa 59.06, maltose 40.5.
4. according to the Chinese patent medicine of each described treatment gynaecopathia in the claim 1 to 3, the medicament that it is characterized in that it is capsule or tablet or granule or soft capsule.
5. according to the preparation method of the Chinese patent medicine of each described treatment gynaecopathia in the claim 1 to 3, it is characterized in that this preparation method comprises the steps:
(1). concoct each medicine respectively
With Cornu Cervi Pantotrichum, the Radix Paeoniae Alba, Radix Angelicae Sinensis, Radix Scutellariae processed with wine; Rhizoma Atractylodis Macrocephalae parching with earth, Rhizoma Cyperi, Rhizoma Corydalis, Oletum Trogopterori vinegar system; Rhizoma Chuanxiong is processed by Rhizoma Zingiberis Recens; The Radix Glycyrrhizae processed with honey; The Cortex Eucommiae, Rhizoma Zingiberis parch to black; Remaining medical material is made back cutting, drying only;
(2). expect in the middle of preparing each respectively
-Yunnan Caulis Spatholobi decocts with water three times, filters, and filtrate is condensed into thick paste, and oven dry is pulverized, and sieves, and it is standby to get Yunnan Caulis Spatholobi cream powder;
-Oryza glutinosa is cleaned, cook, oven dry is pulverized, and sieves, and it is standby to get ripe glutinous rice flour;
-get Radix Ginseng, Radix Notoginseng, Radix Paeoniae Alba (processed with wine) with 50～90% ethanol extractions 2～3 times, filter, filtrate recycling ethanol, clear paste A is standby;
-the Rhizoma Atractylodis Macrocephalae (parched) that fetches earth, Rhizoma Cyperi (processed with vinegar), Radix Bupleuri, Cortex Cinnamomi, Fructus Amomi, Herba Asari, Radix Angelicae Sinensis (processed with wine), Rhizoma Zingiberis Recens are processed Rhizoma Chuanxiong and extract volatile oil, and volatile oil and the surplus medicinal residues of institute are standby respectively;
-get medicinal residues behind Radix Cyathulae, Radix Glycyrrhizae Preparata and the said extracted volatile oil of Flos Carthami, Fructus Lycii, Herba Leonuri, Faeces Trogopteri (processed with vinegar), Poria, Fructus Leonuri, the Radix Linderae, Rhizoma Corydalis (processed with vinegar), Radix Scutellariae (processed with wine), recipe quantity 60%～80% of Radix Rehmanniae Preparata, recipe quantity 80.6%～99.6% with water extraction 2～3 times, filter, filtrate directly concentrates or passes through resin absorption, eluting, reconcentration, it is standby to get clear paste B;
(3). the Radix Cyathulae of the recipe quantity 20%～40% of remaining part and Flos Carthami and Radix Dipsaci, the Semen sojae atricolor of recipe quantity 0.4%～19.4% are decocted with water three times, collecting decoction, filter, filtrate is concentrated into relative density 1.20～1.30, add Yunnan Caulis Spatholobi cream powder, ripe glutinous rice flour and maltose, fully mix thoroughly, drying, the C that gets dry extract is standby;
(4). get Colla Corii Asini, charred Cortex Eucommiae, carbonized Rhizoma Zingiberis, Cornu Cervi Pantotrichum (processed with wine), Cornu Cervi Degelatinatum, Stigma Croci and dried cream C and be ground into powder or be broken into micropowder through superfine powder, standby;
(5). with the powder of above-mentioned steps (4) or micropowder and clear paste A, clear paste B mix homogeneously, crushed after being dried is powder D;
(6). add volatile oil;
(7). make capsule, tablet, granule, soft capsule medicine with diverse ways.
6. preparation method according to claim 5 is characterized in that described extraction volatile oil adopts steam distillation, or supercritical extraction, or milling process.
7. preparation method according to claim 5 is characterized in that in the described step (7):
-powder D and volatile oil mix homogeneously take a morsel;
-adding all the other powder D and filler mix homogeneously again, its ratio is: powder D 96～99.5%, filler 0.5～4.0%;
-be filled into capsule, promptly get the capsule medicine.
8. preparation method according to claim 5 is characterized in that in the described step (7):
-adding disintegrating agent mix homogeneously in powder D;
-add binding agent with the compound moistening;
-wet feed is made granule, drying;
-with the beta-cyclodextrin inclusion compound volatile oil of 4 times of amounts of volatile oil, to sneak into then in the granule, the adding mix lubricant is even;
-with tablet machine with the hybrid particles tablet forming, promptly get the tablet medicine;
The weight percent proportioning of described powder D and adjuvant is: powder D83%～98.9%, disintegrating agent 0.1～10%, binding agent 0.5～5.0%, lubricant 0.5～2.0%.
9. preparation method according to claim 5 is characterized in that in the described step (7):
-adding filler mix homogeneously in powder D;
-add binding agent with the compound moistening;
-wet feed is made granule, drying;
-with calcium sulfate or the starch or the micropowder silica gel absorption volatile oil of 4 times of amounts of volatile oil, sneak into then in the granule, promptly get the granule medicine;
The weight percent proportioning of described powder D and adjuvant is: powder D 65%～89.5%, filler 10～30%, binding agent 0.5～5.0%.
10. preparation method according to claim 5 is characterized in that in the described step (7):
-with the beta-cyclodextrin inclusion compound volatile oil of 4 times of amounts of volatile oil, sneak into then and get compound among the powder D;
-adding the vegetable oil of above-mentioned compound 15% again, pill promptly gets the soft capsule medicine.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100217508A CN100402081C (en) | 2005-09-26 | 2005-09-26 | Chinese patent medicine for treating gynaecologic disease and preparing method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100217508A CN100402081C (en) | 2005-09-26 | 2005-09-26 | Chinese patent medicine for treating gynaecologic disease and preparing method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1742993A CN1742993A (en) | 2006-03-08 |
| CN100402081C true CN100402081C (en) | 2008-07-16 |
Family
ID=36138617
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2005100217508A Expired - Fee Related CN100402081C (en) | 2005-09-26 | 2005-09-26 | Chinese patent medicine for treating gynaecologic disease and preparing method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN100402081C (en) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101099790B (en) * | 2007-07-24 | 2010-12-08 | 徐究竟 | Proprietary Chinese medicine for preventing vitro fertilization-embryo implanting postoperative fallopian tube ectopic pregnancy and preparation technology thereof |
| CN101129971B (en) * | 2007-09-25 | 2010-11-24 | 徐有章 | Traditional Chinese medicine composition for treating women's menorrhalgia and menoxenia, and method of preparing the same |
| CN101461926B (en) * | 2009-01-15 | 2011-04-20 | 郁慧 | Medicament composition for treating gland hyperplasia and preparation method thereof |
| CN101757599B (en) * | 2010-02-01 | 2011-04-13 | 刘同亭 | Medicinal granules comprising brown sugar, Colla corii Asini, Cornu cervi Pantotrichum, ginseng, clove, costus root, red jujube and tea |
| CN101816735B (en) * | 2010-04-29 | 2012-02-08 | 王敬一 | External medicinal pad for treating gynecological diseases |
| CN102886036B (en) * | 2012-10-12 | 2013-10-30 | 孙丽 | Traditional Chinese medicine for treating syndrome of congealing cold with blood stasis type dysmenorrheal disease |
| CN103768355A (en) * | 2012-10-25 | 2014-05-07 | 方山玉 | Manufacturing method for traditional Chinese medicine honeyed pill for treating women diseases |
| CN103263647B (en) * | 2013-04-27 | 2015-02-11 | 青岛市市立医院 | Traditional Chinese medicine for treating postnatal lochiorrhea and preparation method thereof |
| CN103610876A (en) * | 2013-11-29 | 2014-03-05 | 孟山福 | Medicine for treating menorrhagia in female menstrual period |
| CN103948883B (en) * | 2014-03-28 | 2016-08-17 | 宋剑 | A kind of Chinese medicine composition treating infertility |
| CN104623129B (en) * | 2015-01-20 | 2018-12-28 | 浙江九如堂生物科技有限公司 | A kind of Chinese medicine composition and preparation method thereof with promoting blood circulation for regulating menstruation analgesic effect |
-
2005
- 2005-09-26 CN CNB2005100217508A patent/CN100402081C/en not_active Expired - Fee Related
Non-Patent Citations (2)
| Title |
|---|
| . 国家药品监督管理局.国家中成药标准汇编（中成药地方标准上升国家标准部分）. 2002 |
| . 国家药品监督管理局.国家中成药标准汇编（中成药地方标准上升国家标准部分）. 2002 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1742993A (en) | 2006-03-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN100402081C (en) | Chinese patent medicine for treating gynaecologic disease and preparing method | |
| CN103007234B (en) | Traditional Chinese medicine preparation for treating dysmenorrheal caused by endometriosis and preparation method of preparation | |
| CN103041209B (en) | Chinese herbal preparation for curing deficiency of kidney-yin and preparation method thereof | |
| CN103041208B (en) | Chinese herbal preparation for treating climacteric syndrome of women, and preparation method thereof | |
| CN104940740A (en) | Traditional Chinese medicine composition for treating polycystic ovarian syndrome and preparation method thereof | |
| CN104258066A (en) | Traditional Chinese medicine preparation for treating kidney-yin deficiency-type dysfunctional uterine bleeding, and preparation method thereof | |
| CN104666579A (en) | Traditional Chinese medicine composition for treating gonarthromeningitis and preparation method of traditional Chinese medicine composition | |
| CN103536838B (en) | A kind of Chinese medicine preparation for the treatment of threatened abortion and preparation method thereof | |
| CN101095923B (en) | Chinese traditional medicine for treating ectopic pregnancy | |
| CN106728863A (en) | It is a kind of to treat Chinese medicine of diabetes and preparation method thereof | |
| CN104721582A (en) | Medicine for treating hypomenorrhea due to deficiency of kidney and preparation method thereof | |
| CN103330837B (en) | Traditional Chinese medicine composition for curing osteoporosis of menopausal women | |
| CN105412859A (en) | Chinese medicine composition for preventing and treating postpartum puerperal fever and preparation method thereof | |
| CN105796845A (en) | Application of medicine composition in preparing medicine for treating female climacteric syndromes | |
| CN103860773A (en) | Traditional Chinese medicine composition for treating myocardial ischemia and preparation method thereof | |
| CN102091254B (en) | Traditional Chinese medicine composition for relieving swelling after cosmetic surgery and preparation method thereof | |
| CN105362629A (en) | Female climacteric syndrome treatment pharmaceutical composition containing cortex eucommiae and preparation method of female climacteric syndrome treatment pharmaceutical composition containing cortex eucommiae | |
| CN105362587A (en) | Composition capable of improving infertility caused by endocrine dyscrasia and preparation method thereof | |
| CN105395842A (en) | Traditional Chinese medicine composition for treating diabetes and oral preparation and preparation method thereof | |
| CN105169265A (en) | Traditional Chinese medicine composition for treating hemiplegia and preparation method of traditional Chinese medicine composition | |
| CN100358566C (en) | Traditional Chinese medicine preparation for treating internal weakness | |
| CN109200162A (en) | A kind of Chinese materia medica preparation that treating Stein-Leventhal syndrome and preparation method | |
| CN104825892B (en) | A kind of Chinese medicine preparation for treating ovulation bleeding and preparation method thereof | |
| CN114712470B (en) | Medicine for treating deficiency of kidney of men and preparation method thereof | |
| CN106177451A (en) | The Chinese medicine suppository preparation method for the treatment of women's ovary senilism and suppository thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20080716 Termination date: 20100926 |