CN105362587A - Composition capable of improving infertility caused by endocrine dyscrasia and preparation method thereof - Google Patents
Composition capable of improving infertility caused by endocrine dyscrasia and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a composition capable of improving infertility caused by endocrine dyscrasia and a preparation method thereof. The composition comprises, by weight, 10-20 parts of Saussurea involucrata, 15-25 parts of red date, 10-20 parts of motherwort, 2-8 parts of Chinese yam, 7-10 parts of litchi, 2-4 parts of Salvia miltiorrhiza, 3-5 parts of Radix rehmanniae preparata, 5-15 parts of goat meat, 2-6 parts of Cortex cinnamomi, 10-15 parts of Boschniakia rossica, 15-25 parts of Fructus ligustri lucidi, 10-20 parts of tremella, 5-15 parts of agaric and 4-8 parts of lotus seed. The composition pays attention to the whole, can improve infertility caused by endocrine dyscrasia and can regulate endocrine; more importantly, traditional Chinese medicinal materials different in efficacy are combined together, which is a major characteristic different from medication. The composition is prepared completely according to principles of traditional Chinese medicine, thereby being safer and more reliable, free of any toxic and side effect and completely non-irritant to organisms.
Description
Technical field
The invention belongs to traditional Chinese medicine field, relate to the infertile composition and method of making the same that a kind of endocrine disturbance of improvement causes.
Background technology
Endocrine is the regulation and control person of human physiological functions, and it is played a role in human body by secreting hormone.Such as, antibacterial enters human body, and thymosin just can increase secretion automatically, to resist pathogenic bacteria; Female menstrual period, progestogen also can increase, and estrogen is corresponding minimizing then.If because some cause of disease, the hormonosis causing endocrine gland to secrete or very few, metabolic function is disorderly, will cause endocrine disturbance, cause endocrinopathy to occur, comprise female acyesis.
Common manifestation: luteal phase defect is the infertile modal performance of dyscrinic.Women's luteal phase defect has many harm to health.Luteal phase defect main manifestations be menstrual cycle shorten but menstrual period normal, through to measure normally or slightly many, companion's history of spontaneous abortion.Often auxiliary examination need be relied on to make a definite diagnosis.In fact, the Recurrent spontaneous abortion of nearly 35% ~ 40% is caused by luteal phase defect.During normal pregnancy, ovum starts the implantation of film implantation in uterus at after fertilization 5 ~ 7d, and trophoblastic cell starts to secrete chorionic-gonadotropin hormone (HCG), and HCG stimulates corpus luteum continuation growth to grow up, and becomes corpus luteum of pregnancy, makes progesterone continue to produce.When gestation plays luteal function decline for 6 weeks, trophoblast synthesis progesterone starts.Therefore the most easily miscarry when pregnant 6 ~ 7 weeks.As luteal phase defect comprises the corpus luteum lost of life, and corpus luteum secretory function is low, so that progesterone secretion quantity not sufficient, after the bad or early pregnancy of endometrial secretory reaction, decidua reaction is bad, cause cytula not easily after implantation or implantation development of fertilized ovum be affected, cause miscarriage.Luteal phase defect is large on female pathology impact, and women occurs that the symptom of luteal phase defect needs timely hospital treatment.
Disease reason: 1, ovulation failure: the various endocrine function ovulation failure caused of lacking of proper care all can directly cause infertile.
2, congenital disorders of sex differentiation: mainly comprise Hyperandrogenism, hypoandrogenism, the diseases such as androgen dysfunction.3, the amenorrhea that causes of endocrine factors: amenorrhea is a kind of extremely form of infrequent menstruation.Primary amenorrhea and secondary amenorrhea can be divided into.Primary amenorrhea to refer to after women 18 one full year of life the still menolipsis person of rising; Secondary amenorrhea refers to once well-regulated menstruation, and causes for a certain reason and stop menstruation more than 3 months persons.4, polycystic ovary syndrome: there is menoxenia, amenorrhea, anovulation hirsutism, obesity, the increase of infertile merging bilateral ovaries in many capsule changes.5, hirsutism is with manlike: hirsutism refers to compared with women and its women of the same age of the same clan, or compared with before he or she's disease, hair undue growth, thicker, blackening.Manlike is a kind of clinical syndrome, refers to that women is except performance hirsutism, still have clitoridauxe, muscular, have a low and deep voice, facial acne, male pattern alopecia, women's secondary sex characteristics go down or disappear and amenorrhea etc.Hirsutism and butch be to increase in various degree or caused by whole non-organ increases androgenic sensitivity because a variety of causes causes body inner estrogen level.6, high lactogenic mass formed by blood stasis: Prolactin is abnormal too high infertilely or sterile comprises amenorrhea, galactorrhea, hypomenorrhea and rare, luteal phase defect and ovulation.7, thyroid: hyperthyroidism, go down, struma lymphomatosa etc. all can affect ovulation and cause infertile.9, luteal phase defect: menstruation in advance, dripping not to the utmost, palace blood forms anovulation type menstruation etc.10, other as: diabetes, adrenal gland's cryptorrhea etc. also can affect ovary ovulation.
Endocrine disturbance is the major reason causing female acyesis, and the foundation of normal ovulatory cycle needs hypothalamic-pituitary-ovarian s function normal in fact.Wherein any one position dysfunction all may cause not ovulating, and thus causes menolipsis, hypomenorrhea, anovulatory dysfunctional uterine hemorrhage etc., carries out causing infertility, the infertility caused due to this endocrine reason and dyscrinic infertile.Along with the development of Chinese Chinese medicine, on treatment dyscrinic is infertile, it is little that people appreciate the infertile side effect for the treatment of by Chinese herbs dyscrinic gradually, bear painful little advantage, and Chinese traditional treatment great attention to whole idea, pay attention to comprehensive control, pay attention to determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, therapeutic effect demonstrates treatment by Chinese herbs dyscrinic infertile advantage more.Chinese medicine has endocrine regulation, compensate qi and blood, improves qi-blood circulating, the special efficacy of hard masses softening and resolving, and persistent, treating both the principal and secondary aspects of a disease, has no side effect and efficacy consolidation, not easily to recur.
Summary of the invention
Along with the development of Chinese Chinese medicine, on Cure and control endocrine disturbance type is infertile, people gradually appreciate Chinese medicine and improve the sterility treatment process that endocrine disturbance causes and have no side effect, patient bears painful little, the advantage that cost is saved relatively, the infertile present situation that endocrine disturbance causes is improved for existing doctor trained in Western medicine, an object of the present invention is the infertile compositions providing a kind of endocrine disturbance of improvement to cause, there is feature easy to operate, evident in efficacy, and it adopts Chinese crude drug comparatively common in the localities as raw material, with low cost.
Above-mentioned purpose of the present invention is achieved through the following technical solutions:
Improve the infertile compositions that endocrine disturbance causes, each raw material is as follows, is weight portion: Herba Saussureae Involueratae 10-20, Fructus Jujubae 15-25, Herba Leonuri 10-20, Rhizoma Dioscoreae 2-8, Fructus Litchi 7-10, Radix Salviae Miltiorrhizae 2-4, Radix Rehmanniae Preparata 3-5, Carnis Naemorhedi 5-15, Cortex Cinnamomi 2-6, Herba Boschniakiae Rossicae 10-15, Fructus Ligustri Lucidi 15-25, Tremella 10-20, Auricularia 5-15, Semen Nelumbinis 4-8.
Improve the infertile compositions that endocrine disturbance causes, preferred scheme, each raw material is as follows, be weight portion: Herba Saussureae Involueratae 13-18, Fructus Jujubae 18-23, Herba Leonuri 13-18, Rhizoma Dioscoreae 4-6, Fructus Litchi 8-9, Radix Salviae Miltiorrhizae 2.5-3.5, Radix Rehmanniae Preparata 3.5-4.5, Carnis Naemorhedi 8-13, Cortex Cinnamomi 3-5, Herba Boschniakiae Rossicae 11-14, Fructus Ligustri Lucidi 18-23, Tremella 13-18, Auricularia 8-13, Semen Nelumbinis 5-7.
Improve the infertile compositions that endocrine disturbance causes, better preferred scheme, each raw material is as follows, be weight portion: Herba Saussureae Involueratae 15, Fructus Jujubae 20, Herba Leonuri 15, Rhizoma Dioscoreae 5, Fructus Litchi 8.5, Radix Salviae Miltiorrhizae 3, Radix Rehmanniae Preparata 4, Carnis Naemorhedi 10, Cortex Cinnamomi 4, Herba Boschniakiae Rossicae 12.5, Fructus Ligustri Lucidi 20, Tremella 15, Auricularia 10, Semen Nelumbinis 6.
Improve a preparation method for the infertile compositions that endocrine disturbance causes, be prepared from primarily of following step:
1. Herba Leonuri, Radix Salviae Miltiorrhizae, Radix Rehmanniae Preparata, Cortex Cinnamomi, Herba Boschniakiae Rossicae and Fructus Ligustri Lucidi are cleaned up, be placed in marmite, add light salt brine, the ratio of salt and water is 1:3, and intense fire is fried open, and turns slow fire boiling 40-60 minute, filter, obtain filtrate, filtering residue adds light salt brine again, slow fire simmers 50-70 minute, filter, obtain filtrate, twice filtrate mixing, leave standstill 5-10 hour, obtain supernatant stand-by;
2. be divided into two by Fructus Jujubae, enucleation, removes the peel Rhizoma Dioscoreae, cleans, and mixes stand-by by the Fructus Jujubae handled well and Rhizoma Dioscoreae;
3. Herba Saussureae Involueratae, Tremella, Auricularia and Semen Nelumbinis are first clean by cold water flush, be placed in the bowl of porcelain, add the warm water of 30-40 DEG C, soak 20-40 minute, with strainer, soaked Herba Saussureae Involueratae, Tremella, Auricularia and Semen Nelumbinis are taken out, then rush with cold water stand-by;
4. thin slice Carnis Naemorhedi being cut into coin-size is placed in marmite, by step 1. gained supernatant join in marmite, big fire is boiled, until boiling 2-6 minute after add step 2.-3. gains and Fructus Litchi, slow fire simmers 60-120 minute slowly, filter, filtrate is bottled to obtain oral liquid, and it is edible that filtering residue can work as nutriment.
The preparation method of above-mentioned composition, step 1. intense fire is fried open, and turns slow fire boiling 45-55 minute (preferred, intense fire is fried open, and turns slow fire boiling 50 minutes).
The preparation method of above-mentioned composition, step 1. slow fire simmers 55-65 minute, filters, obtains filtrate, twice filtrate mixing, leaves standstill 6-9 hour (preferred, slow fire simmers 60 minutes, filters, obtains filtrate, and twice filtrate mixing, leaves standstill 7.5 hours).
The preparation method of above-mentioned composition, 3. step adds the warm water of 33-38 DEG C, soaks 25-35 minute (preferred, to add the warm water of 35 DEG C, soak 30 minutes).
The preparation method of above-mentioned composition, step 4. until boiling add after 3-5 minute step 2.-3. gains (preferred, until boiling add after 4 minutes step 2.-3. gains).
The preparation method of above-mentioned composition, step 4. slow fire is simmered 80-100 minute (preferred, slow fire simmers 90 minutes slowly) slowly.
The infertile Be very effective of said composition Endocrine dysfunctional, patient is not only made to be pregnant to nurse a baby youngster to do the right of mother, maintain uterus in addition, nurse one's health effect of inherent physiological system, can recover and supplement the inherent true strength, the vital qi that have damaged, the local common medical material of multiselect of the present invention, cheap, alleviate the financial burden of patient.
The pharmacological effect of each crude drug is respectively:
Herba Saussureae Involueratae: Herba Saussureae Involueratae beautifying face-applying cream: the metabolism that can accelerate skin, reduces wrinkle, makes skin keep gloss, plentiful.Slow down aging, and have good curative effect to facial freckle, chloasma hepaticum etc.Free radical resisting and resisting fatigue: from Herba Saussureae Involueratae, extract polysaccharide first, record this polysaccharide by nitroblue tetrazolium colorimetry and remove half of ultra-oxygen anion free radical to remove concentration be 22.O μ g/ml, and 95% is crediblely limited to 19.9-24.l μ g/ml.Polysaccharide obviously can suppress the generation of mouse liver even slurry thiobarbituric acid reaction thing, and IC50 is that the fresh liver of 2.3mg/g is heavy, 95% credible to be limited to the fresh liver of 2.05-2.55mg/g heavy.Polysaccharide lumbar injection 25mg/kg is used in conjunction 5 days can reduce mice oxygen consumption 34.4%, and the same dosage of lumbar injection is used in conjunction 6 angel mice swimming times and extends 1.69 times.
Herba Leonuri: pluck when the non-standard-sized sheet of riotous growth flower in summer, acrid in the mouth is bitter, cool, invigorates blood circulation, silts of dispelling, regulating menstruation, disappears water, treatment menoxenia, vaginal bleeding during pregnancy difficult labour, retention of placenta, puerperal blood faints, abdominal pain due to blood stasis, metrorrhagia and metrostaxis, hematuria, rushes down blood, carbuncle skin infection.Herba Leonuri has inducing diuresis to remove edema, shrinks the effect of uterus effect, is that ancient Chinese medicine doctor is used for treating gynopathic key medicine.
Herba Leonuri can all herbal medicine, and effective ingredient is Herba Leonuri element, and Herba Leonuri is containing multiple alkaloid and benzoic acid, potassium chloride etc. such as leonurine, stachydrine, leonuridine, leonurinines.Motherwort formulation has the effect of excited animal uterus, similar to pituitrin, and Herba Leonuri extractum and decoct have strong and lasting excitation to uterus, not only can strengthen its contractility, can improve its tensity and shrinkage factor simultaneously.
Fructus Jujubae: Fructus Jujubae can nourishing blood to tranquillize the mind, nourishing spleen and stomach, if old crowd often edible Fructus Jujubae, can health invigorating, slow down aging; If working clan eats Fructus Jujubae, appetite can be increased, the emotion of keeping tensions down; If steep one cup of red date tea evening, can effective Cure for insomnia.Fructus Jujubae is warm in nature, sweet in the mouth, has effect of vigorate qi and replenish the blood, invigorating the spleen and regulating the stomach, Eradicates wind, increases the serum transaminase for the treatment of anaphylactoid purpura, anemia, hypertension, acute, chronic hepatitis and liver cirrhosis patient and prevents transfusion reaction etc. all to have desirable effect; Fructus Jujubae contains triterpenoid compound and cyclic adenosine monophosphate, has stronger to press down cancer, anti-allergic effects; Material containing antifatigue effect in Fructus Jujubae, can strengthen the endurance of people; Fructus Jujubae also has and alleviates toxicant effect to liver injury; Flavone compound in Fructus Jujubae, has the effect of calm blood pressure lowering.Fructus Jujubae sweet in the mouth is warm in nature, taste warp, has invigorating the spleen and replenishing QI, nourishing blood to tranquillize the mind, relaxes the function of the property of medicine.Modern pharmacological research finds, Fructus Jujubae can make oxygen content in blood strengthen, nourish systemic cell, is the analeptic that a kind of drug effect relaxes.
Rhizoma Dioscoreae: Rhizoma Dioscoreae has and nourishes strong, aid digestion, hold back sweating due to debility, effect of antidiarrheal, cure mainly insufficiency of the spleen diarrhoea, cough due to deficiency of the lung, diabetes are quenched one's thirst, oliguria frequently, seminal emission, women's leukorrhagia and dyspeptic chronic enteritis.Rhizoma Dioscoreae has induction and produces interferon, strengthens the effect of immune function of human body.Choline contained by it and lecithin contribute to improving man memory power, normal food can body-building, slow down aging, be the health-care good product that people like.Be the main and auxiliary bionic foods made with Rhizoma amorphophalli with Rhizoma Dioscoreae, having effect of nutritious, healthcare, skin maintenance, is rare health-nutrition cuisines.
Fructus Litchi: Fructus Litchi sweet in the mouth, acid, warm in nature, enters the heart, spleen, Liver Channel; Can stop singultus, only diarrhoea, is the dietetic therapy good merchantable brand of intractable singultus and diarrhea before dawn person, has supplementing the brain body-building simultaneously, and appetizing strengthening the spleen, has the effect promoting appetite.Fructus Litchi sweet in the mouth, acid, warm in nature, enter the heart, spleen, Liver Channel; Sarcocarp has spleen reinforcing the liver benefiting, regulate the flow of vital energy enrich blood, effect of warming middle-JIAO to relieve pain, heart tonifying and tranquilizing; Core have regulate the flow of vital energy, eliminating stagnation, pain relieving effect; Can stop singultus, only diarrhoea, is the dietetic therapy good merchantable brand of intractable singultus and diarrhea before dawn person, has supplementing the brain body-building simultaneously, and appetizing strengthening the spleen, has the effect promoting appetite.
Radix Salviae Miltiorrhizae: be the dry root welding technology of labiate Radix Salviae Miltiorrhizae SalviamiltiorrhizaBge..Spring, Qiu Erji excavate, removing silt, dry.Whole nation most area has distribution.Have blood circulation promoting and blood stasis dispelling, inducing menstruation to relieve menalgia, clear away heart-fire relieving restlessness, effect of removing heat from blood eliminating carbuncle.For obstruction of qi in the chest and cardialgia, gastral cavity abdomen hypochondriac pain, abdominal mass abdominal mass is gathered, pyretic arthralgia pain, dysphoria and insomnia, menoxenia, and dysmenorrhea amenorrhea, skin infection swells and ache.
Radix Rehmanniae Preparata: Radix Rehmanniae Preparata has another name called Radix Rehmanniae Preparata or throws oneself on the ground, belong to goatweed, be a kind of first-class Chinese crude drug, there is YIN nourishing effect of enriching blood, can be used for blood deficiency and yellow complexion, dizzy, palpitation and insomnia, menoxenia, the diseases such as metrorrhagia, also diseases such as can be used for hectic fever hectic fever due to YIN-deficiency, the night sweat of deficiency of kidney yin, pass out semen, quench one's thirst is one of deficiency syndrome class nonprescription drugs medicine LIUWEI DIHUANG WAN main component.
Carnis Naemorhedi: for Bovidae klipspringer belongs to the meat that animal QINGYANG, caprin animals ibex and argali belong to animal argali.The property of medicine: sweet, heat.Function cures mainly: tonifying deficiency, helps kidney yang, strengthening bone and muscle.Cure mainly asthenia internal injury, muscles and bones numbness is weak, and spinal column is aching and limp, and sexual impotence essence is cold, and leucorrhea with red and white discharge, blood is cold infertile.
Cortex Cinnamomi: be dried bark, the branch skin of Lauraceae cinnamon Cortex Cinnamomi.Composition: Cortex cinnamomi japonici (Ramulus Cinnamomi) is containing volatile oil 1.89%-2.06%, and its main component is cinnamic aldehyde, accounts for 52.92%-61.20%, also has acetic acid Cortex cinnamomi japonici (Ramulus Cinnamomi) ester, ethyl cinnamate, benzaldehyde benzyl ester, benzaldehyde, coumarin etc.The property of medicine: pungent, sweet, heat.Return kidney, spleen, the heart, Liver Channel.Function cures mainly: mend fire supporing yang, dispersing cold for relieving pain, warming the meridian and promoting blood circulation.Cure mainly insufficiency of kidney-YANG, the aversion to cold and cold limbs of decline of the fire from the gate of life, soreness of the waist and knees, impotence and seminal emission, dysuria or frequency, dyspnea with rapid and short breath of losing heart, all diseases of edema oliguria; Decline of the fire from the gate of life, fire is Gui Yuan not, floating YANG, refusing yang, and heat in the upper and cold in the lower, flushed complexion cold foot, dizziness and tinnitus, and dispute gruel is broken; Spleen-kidney vacuity cold, coldness and pain in the epigastrium, decreased food intake loose stool; Lumbago due to renal deficiency; Arthralgia due to cold-dampnes; Colic of cold type pain, cold womb is infertile, dysmenorrhea amenorrhea, stomachache of being retarded by silt puerperal; Carbuncle of yin nature multiple abscess, or deficiency and coldness carbuncle and ulcer difficulty in discharging of pus, or do not hold back after bursting.
Herba Boschniakiae Rossicae: the herb of position Orobanchaceae Boschniakia plant plait Herba Cistanches.Composition: the sugary glycoside of herb: Herba Boschniakiae Rossicae cinnamyl alcohol glycosides A, B, C, D, Herba Boschniakiae Rossicae glycosides, boschniakine glycosides.Iridoid glycosides, acids: 8-shows the sweet acid of deoxidation Semen Strychni, gallic acid, cinnamic acid, caffeic acid, P-coumaric acid, etc.Aerial parts contains Herba Cistanches aldin, and Herba Boschniakiae Rossicae lactone.The property of medicine: sweet, salty, warm.Function cures mainly: kidney invigorating and YANG supporting, loosening bowel to relieve constipation, hemostasis.Cure mainly impotence due to deficiency of the kidney, seminal emission, chills and pain of the waist and kness, urine loses drop, and hematuria, cold womb is infertile, metrorrhagia, leukorrhagia, dryness of the intestine constipation." modern plants medicine: " be the smart medicine of strong benefit.Control seminal emission, sexual impotence, warm waist knee joint, wish of promoting the sexual maturity.To with cystitis, bladder hemorrhage and kidney hemorrhagic disease time for stop blooding medicinal." " moisten the five internal organs, beneficial marrow, strong muscle, controls five kinds of strain and seven kinds of impairment, and sun is out of fashion absolutely, and exhausted the moon does not produce, chills and pain of the waist and kness, seminal emission leukorrhagia.
Fructus Ligustri Lucidi: be the fruit of Oleaceae Ligustrum plant Fructus Ligustri Lucidi.Composition: fruit is containing triterpenes: oleanolic acid, acetyloleanolic acid, ursolic acid, acetyl ursolic acid; Phenolic glycoside class: p-hydroxyphenylethanol, Hydroxytyrosol, nuzhenide, oleuropein, Fructus Ligustri Lucidi fruit glycosides, Fructus Ligustri Lucidi acid, Fructus Ligustri Lucidi thuja acid etc.The property of medicine: sweet, bitter, cold.Return liver, warp.Function cures mainly: liver and kidney tonifying, clearind deficient heat you, improving eyesight.Cure mainly Light-headedness, soreness of the waist and knees, seminal emission, tinnitus, early whitening of beard and hair, osteopyrexia and fever, poor vision.
Tremella: Tremella has strong essence, the kidney invigorating, intestine moistening, stomach reinforcing, QI invigorating and blood, heart tonifying, strong body, supplementing the brain, refreshes oneself, improves looks, effect of skin care, life lengthening.It can improve liver detoxification ability, the liver protecting function, and it not only can enhancing body antineoplastic immunocompetence, can also strengthen the tolerance of tumor patient to radiotherapy, chemotherapy.Can nourish and promote the production of body fluid; Lung moistening nourishing the stomach, invigorating the lung and benefiting vital QI.Cough due to consumptive disease; Sputum mixed with blood; Tianjin is few thirsty; Body is empty after being ill; Shortness of breath and fatigue.
Auricularia: delicious flavour, can element can meat or fish, nutritious.Auricularia sweet in the mouth, property is put down, and has a lot of medicinal efficacy.Can QI invigorating keep fit, usefulness of invigorating blood circulation, and can iron deficiency anemia etc. be prevented and treated; Can nourish blood and preserve youthful looks, it is ruddy, radiant to make us skin, can dredge the intestines and stomach, and lubrication intestinal, also has certain help to hyperpietic simultaneously.Cure mainly: Qi and blood deficiency; Chronic cough of deficiency lung; Hemoptysis; Epistaxis; Dysentery; Bleeding hemorrhoids; Woman uterine bleeding; Hypertension; Retinal hemorrhage; Cervical cancer; Cancer of vagina; Traumatic pain.
Semen Nelumbinis: sweet in the mouth, puckery, property is put down.Gui Jing: return spleen, kidney, heart channel.Effect: spleen reinforcing antidiarrheal, leukorrhagia stopping, kidney tonifying arresting seminal emission, tranquilizing by nourishing the heart.Cure mainly: for diarrhea due to hypofunction of the spleen, leukorrhagia, seminal emission, palpitation and insomnia.
The beneficial effect of resulting composition of the present invention is: the present composition " more holistic ", that both can improve that endocrine disturbance causes is infertile, scalable endocrine again, by Herba Saussureae Involueratae, Fructus Jujubae, Herba Leonuri, Rhizoma Dioscoreae, Fructus Litchi, Radix Salviae Miltiorrhizae, Radix Rehmanniae Preparata, Carnis Naemorhedi, Cortex Cinnamomi, Herba Boschniakiae Rossicae, Fructus Ligustri Lucidi, Tremella, Auricularia and Semen Nelumbinis are combined, the heart of releiving is strongly fragrant depressed, treatment dysmenorrhea, sleep aiding and nerve soothing, Endocrine disorder type infertile patient has fabulous therapeutical effect, improve the infertile ideal medicine that endocrine disturbance causes at present, and have unique curative effect to the disease such as uterine hypoplasia and ovarian hypofunction.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not by this restriction.
embodiment 1improve the infertile compositions that endocrine disturbance causes, each raw material is as follows, is weight portion (getting 10g for every part): Herba Saussureae Involueratae 10, Fructus Jujubae 15, Herba Leonuri 10, Rhizoma Dioscoreae 2, Fructus Litchi 7, Radix Salviae Miltiorrhizae 2, Radix Rehmanniae Preparata 3, Carnis Naemorhedi 5, Cortex Cinnamomi 2, Herba Boschniakiae Rossicae 10, Fructus Ligustri Lucidi 15, Tremella 10, Auricularia 5, Semen Nelumbinis 4.
Improve the infertile compositions that endocrine disturbance causes, preparation process is as follows:
1. Herba Leonuri, Radix Salviae Miltiorrhizae, Radix Rehmanniae Preparata, Cortex Cinnamomi, Herba Boschniakiae Rossicae and Fructus Ligustri Lucidi are cleaned up, be placed in marmite, add light salt brine, the ratio of salt and water is 1:3, and intense fire is fried open, and turns slow fire boiling 40 minutes, filter, obtain filtrate, filtering residue adds light salt brine again, slow fire simmers 50 minutes, filter, obtain filtrate, twice filtrate mixing, leave standstill 5 hours, obtain supernatant stand-by;
2. be divided into two by Fructus Jujubae, enucleation, removes the peel Rhizoma Dioscoreae, cleans, and mixes stand-by by the Fructus Jujubae handled well and Rhizoma Dioscoreae;
3. Herba Saussureae Involueratae, Tremella, Auricularia and Semen Nelumbinis are first clean by cold water flush, be placed in the bowl of porcelain, add the warm water of 30 DEG C, soak 20 minutes, with strainer, soaked Herba Saussureae Involueratae, Tremella, Auricularia and Semen Nelumbinis are taken out, then rush with cold water stand-by;
4. thin slice Carnis Naemorhedi being cut into coin-size is placed in marmite, by step 1. gained supernatant join in marmite, big fire is boiled, until boiling add after 2 minutes step 2.-3. gains and Fructus Litchi, slow fire simmers 60 minutes slowly, filter, filtrate is bottled to obtain oral liquid, and filtering residue can be worked as nutriment and be eaten.
model case one:wu XX, female, 25 years old, Licheng City, Jinan City, Shandong Province scholar, after patient was engaged in work since 22 years old, facial acne, very ugly, often arrive with menstruation and increase the weight of, accompany alopecia simultaneously, face and a tip heavy wool, because work relationship work and rest is on ordinary days unstable, sleep and breakfast, lunch and dinner all irregular, the situation only entering a meal for one day is even had to occur, constipation, 1 row on the 2/th/3, dry as sheep dung, receiving can, oliguria (the few event of private prosecution drinking-water, mouth is unconsciously thirsty), menstrual phase and amount all abnormal, work after 1 year, within 23 years old, marry, in the time of 2 years, symptom is never got better, and it is not conceived in the time of 2 years, the people of husband's family worrying very, detailed inspection of having gone to hospital to do, because it is infertile that endocrine disturbance causes.
Take embodiment 1 resulting composition, every morning or evening take oral liquid after meal half an hour, if personal like can take well-done Tremella, Auricularia etc., take 10 days, malaise symptoms alleviates, and skin starts to reappear gloss, flexible; Take two weeks, body constitution and complexion are obviously improved, and people has also become vigor; After taking 2 months, endocrine is normal.
embodiment 2:improve the infertile compositions that endocrine disturbance causes, each raw material is as follows, is weight portion (getting 10g for every part): Herba Saussureae Involueratae 20, Fructus Jujubae 25, Herba Leonuri 20, Rhizoma Dioscoreae 8, Fructus Litchi 10, Radix Salviae Miltiorrhizae 4, Radix Rehmanniae Preparata 5, Carnis Naemorhedi 15, Cortex Cinnamomi 6, Herba Boschniakiae Rossicae 15, Fructus Ligustri Lucidi 25, Tremella 20, Auricularia 15, Semen Nelumbinis 8.
Improve the infertile compositions that endocrine disturbance causes, preparation process is as follows:
1. Herba Leonuri, Radix Salviae Miltiorrhizae, Radix Rehmanniae Preparata, Cortex Cinnamomi, Herba Boschniakiae Rossicae and Fructus Ligustri Lucidi are cleaned up, be placed in marmite, add light salt brine, the ratio of salt and water is 1:3, and intense fire is fried open, and turns slow fire boiling 60 minutes, filter, obtain filtrate, filtering residue adds light salt brine again, slow fire simmers 70 minutes, filter, obtain filtrate, twice filtrate mixing, leave standstill 10 hours, obtain supernatant stand-by;
2. be divided into two by Fructus Jujubae, enucleation, removes the peel Rhizoma Dioscoreae, cleans, and mixes stand-by by the Fructus Jujubae handled well and Rhizoma Dioscoreae;
3. Herba Saussureae Involueratae, Tremella, Auricularia and Semen Nelumbinis are first clean by cold water flush, be placed in the bowl of porcelain, add the warm water of 40 DEG C, soak 40 minutes, with strainer, soaked Herba Saussureae Involueratae, Tremella, Auricularia and Semen Nelumbinis are taken out, then rush with cold water stand-by;
4. thin slice Carnis Naemorhedi being cut into coin-size is placed in marmite, by step 1. gained supernatant join in marmite, big fire is boiled, until boiling add after 6 minutes step 2.-3. gains and Fructus Litchi, slow fire simmers 120 minutes slowly, filter, filtrate is bottled to obtain oral liquid, and filtering residue can be worked as nutriment and be eaten.
embodiment 3:improve the infertile compositions that endocrine disturbance causes, each raw material is as follows, is weight portion (getting 10g for every part): Herba Saussureae Involueratae 13, Fructus Jujubae 18, Herba Leonuri 13, Rhizoma Dioscoreae 4, Fructus Litchi 8, Radix Salviae Miltiorrhizae 2.5, Radix Rehmanniae Preparata 3.5, Carnis Naemorhedi 8, Cortex Cinnamomi 3, Herba Boschniakiae Rossicae 11, Fructus Ligustri Lucidi 18, Tremella 13, Auricularia 8, Semen Nelumbinis 5.
Improve the infertile compositions that endocrine disturbance causes, preparation process is as follows:
1. Herba Leonuri, Radix Salviae Miltiorrhizae, Radix Rehmanniae Preparata, Cortex Cinnamomi, Herba Boschniakiae Rossicae and Fructus Ligustri Lucidi are cleaned up, be placed in marmite, add light salt brine, the ratio of salt and water is 1:3, and intense fire is fried open, and turns slow fire boiling 55 minutes, filter, obtain filtrate, filtering residue adds light salt brine again, slow fire simmers 65 minutes, filter, obtain filtrate, twice filtrate mixing, leave standstill 9 hours, obtain supernatant stand-by;
2. be divided into two by Fructus Jujubae, enucleation, removes the peel Rhizoma Dioscoreae, cleans, and mixes stand-by by the Fructus Jujubae handled well and Rhizoma Dioscoreae;
3. Herba Saussureae Involueratae, Tremella, Auricularia and Semen Nelumbinis are first clean by cold water flush, be placed in the bowl of porcelain, add the warm water of 38 DEG C, soak 35 minutes, with strainer, soaked Herba Saussureae Involueratae, Tremella, Auricularia and Semen Nelumbinis are taken out, then rush with cold water stand-by;
4. thin slice Carnis Naemorhedi being cut into coin-size is placed in marmite, by step 1. gained supernatant join in marmite, big fire is boiled, until boiling add after 5 minutes step 2.-3. gains and Fructus Litchi, slow fire simmers 80 minutes slowly, filter, filtrate is bottled to obtain oral liquid, and filtering residue can be worked as nutriment and be eaten.
embodiment 4improve the infertile compositions that endocrine disturbance causes, each raw material is as follows, is weight portion (getting 10g for every part): Herba Saussureae Involueratae 18, Fructus Jujubae 23, Herba Leonuri 18, Rhizoma Dioscoreae 6, Fructus Litchi 9, Radix Salviae Miltiorrhizae 3.5, Radix Rehmanniae Preparata 4.5, Carnis Naemorhedi 13, Cortex Cinnamomi 5, Herba Boschniakiae Rossicae 14, Fructus Ligustri Lucidi 23, Tremella 18, Auricularia 13, Semen Nelumbinis 7.
Improve the infertile compositions that endocrine disturbance causes, preparation process is as follows:
1. Herba Leonuri, Radix Salviae Miltiorrhizae, Radix Rehmanniae Preparata, Cortex Cinnamomi, Herba Boschniakiae Rossicae and Fructus Ligustri Lucidi are cleaned up, be placed in marmite, add light salt brine, the ratio of salt and water is 1:3, and intense fire is fried open, and turns slow fire boiling 55 minutes, filter, obtain filtrate, filtering residue adds light salt brine again, slow fire simmers 65 minutes, filter, obtain filtrate, twice filtrate mixing, leave standstill 9 hours, obtain supernatant stand-by;
2. be divided into two by Fructus Jujubae, enucleation, removes the peel Rhizoma Dioscoreae, cleans, and mixes stand-by by the Fructus Jujubae handled well and Rhizoma Dioscoreae;
3. Herba Saussureae Involueratae, Tremella, Auricularia and Semen Nelumbinis are first clean by cold water flush, be placed in the bowl of porcelain, add the warm water of 38 DEG C, soak 35 minutes, with strainer, soaked Herba Saussureae Involueratae, Tremella, Auricularia and Semen Nelumbinis are taken out, then rush with cold water stand-by;
4. thin slice Carnis Naemorhedi being cut into coin-size is placed in marmite, by step 1. gained supernatant join in marmite, big fire is boiled, until boiling add after 5 minutes step 2.-3. gains and Fructus Litchi, slow fire simmers 100 minutes slowly, filter, filtrate is bottled to obtain oral liquid, and filtering residue can be worked as nutriment and be eaten.
model case two:liu XX, female, 29 years old, people from Liaocheng, Shandong Province, patient marries for 27 years old, facial acne, intense darkness without light, acne increases the weight of with menstruation, hurt like hell when menstruation comes, and amount is few, darkish complexion, go to register the department of Chinese medicine, the traditional Chinese medical science predicates the imbalance of liver spleen kidney, entirety seemingly belongs to YinXuXueRe, damp and hot, the cause of disease is with work and rest is indefinite, drinking and eating irregularly relation of sleeping is very large, opened the oral traditional Chinese medical science to it, but symptom has no improvement, and menstruation half a year recently comes twice, always conceived after marriage, the infertile and above-mentioned malaise symptoms going to central hospital of city to check to be diagnosed as endocrine disturbance and to cause.
Take embodiment 4 resulting composition, every morning or evening take oral liquid after meal half an hour, if personal like can take well-done Tremella, Auricularia etc., after taking 10 days, the sensation colour of skin has been got well, and has the sensation of one heat heat in body, continue to take 1 month, there is no the symptom of dysmenorrhea time in the period, continue again to take 2 months, conceived.
embodiment 5improve the infertile compositions that endocrine disturbance causes, each raw material is as follows, is weight portion (getting 10g for every part): Herba Saussureae Involueratae 15, Fructus Jujubae 20, Herba Leonuri 15, Rhizoma Dioscoreae 5, Fructus Litchi 8.5, Radix Salviae Miltiorrhizae 3, Radix Rehmanniae Preparata 4, Carnis Naemorhedi 10, Cortex Cinnamomi 4, Herba Boschniakiae Rossicae 12.5, Fructus Ligustri Lucidi 20, Tremella 15, Auricularia 10, Semen Nelumbinis 6.
Improve the infertile compositions that endocrine disturbance causes, preparation process is as follows:
1. Herba Leonuri, Radix Salviae Miltiorrhizae, Radix Rehmanniae Preparata, Cortex Cinnamomi, Herba Boschniakiae Rossicae and Fructus Ligustri Lucidi are cleaned up, be placed in marmite, add light salt brine, the ratio of salt and water is 1:3, and intense fire is fried open, and turns slow fire boiling 50 minutes, filter, obtain filtrate, filtering residue adds light salt brine again, slow fire simmers 60 minutes, filter, obtain filtrate, twice filtrate mixing, leave standstill 7.5 hours, obtain supernatant stand-by;
2. be divided into two by Fructus Jujubae, enucleation, removes the peel Rhizoma Dioscoreae, cleans, and mixes stand-by by the Fructus Jujubae handled well and Rhizoma Dioscoreae;
3. Herba Saussureae Involueratae, Tremella, Auricularia and Semen Nelumbinis are first clean by cold water flush, be placed in the bowl of porcelain, add the warm water of 35 DEG C, soak 30 minutes, with strainer, soaked Herba Saussureae Involueratae, Tremella, Auricularia and Semen Nelumbinis are taken out, then rush with cold water stand-by;
4. thin slice Carnis Naemorhedi being cut into coin-size is placed in marmite, by step 1. gained supernatant join in marmite, big fire is boiled, until boiling add after 4 minutes step 2.-3. gains and Fructus Litchi, slow fire simmers 90 minutes slowly, filter, filtrate is bottled to obtain oral liquid, and filtering residue can be worked as nutriment and be eaten.
experimental example:clinical data: 1, physical data
:in order to verify the effect of the present composition, from January, 2012 in January, 2014 in 4 hospitals, have chosen the experiment (embodiment 5) that infertile patient that 400 routine endocrine disturbance cause has carried out medicine, be divided into matched group and experimental group, matched group 200 people, experimental group 200 people
2, Therapeutic Method: every morning or evening take oral liquid after meal half an hour, if personal like can take well-done Tremella, Auricularia etc.
3, criterion of therapeutical effect: effective: common sympton alleviates substantially is invalid: malaise symptoms is all unchanged.In order to verify the effect of the present composition, We conducted the experiment (embodiment 5) of medicine, and accurately statistics and mathematical analysis having been carried out to data.
Specific experiment result is as following table:
Table 1:
Between the operating period, patient's self-induction symptom is as shown in table 2:
Table 2:
Prove through clinical trial, use the present composition and other improve compared with the infertile means that endocrine disturbance causes, rapid-action, treatment means is more comprehensive thoroughly, have no side effect between the operating period, improve that endocrine disturbance causes infertile while, can alleviate by symptoms such as infertile infertile, the stomachache brought of endocrine disturbance's type.Prove through clinical trial, Chinese drugs agentia effective percentage of the present invention is 99%, good therapeutical effect is all had for endocrine disturbance's type is infertile, for endocrine disturbance's type infertile patient, use the present composition, effectively improve that endocrine disturbance causes infertile while, can also treat uterine hypoplasia, dysmenorrhea, therefore the present composition is a kind of infertile medicine improving endocrine disturbance safely and effectively and cause.
Claims (9)
1. improve the infertile compositions that endocrine disturbance causes, it is characterized in that: each raw material is as follows, is weight portion: Herba Saussureae Involueratae 10-20, Fructus Jujubae 15-25, Herba Leonuri 10-20, Rhizoma Dioscoreae 2-8, Fructus Litchi 7-10, Radix Salviae Miltiorrhizae 2-4, Radix Rehmanniae Preparata 3-5, Carnis Naemorhedi 5-15, Cortex Cinnamomi 2-6, Herba Boschniakiae Rossicae 10-15, Fructus Ligustri Lucidi 15-25, Tremella 10-20, Auricularia 5-15, Semen Nelumbinis 4-8.
2. improve the infertile compositions that endocrine disturbance causes according to claim 4, it is characterized in that: each raw material is as follows, is weight portion: Herba Saussureae Involueratae 13-18, Fructus Jujubae 18-23, Herba Leonuri 13-18, Rhizoma Dioscoreae 4-6, Fructus Litchi 8-9, Radix Salviae Miltiorrhizae 2.5-3.5, Radix Rehmanniae Preparata 3.5-4.5, Carnis Naemorhedi 8-13, Cortex Cinnamomi 3-5, Herba Boschniakiae Rossicae 11-14, Fructus Ligustri Lucidi 18-23, Tremella 13-18, Auricularia 8-13, Semen Nelumbinis 5-7.
3. improve the infertile compositions that endocrine disturbance causes according to claim 4, it is characterized in that: each raw material is as follows, is weight portion: Herba Saussureae Involueratae 15, Fructus Jujubae 20, Herba Leonuri 15, Rhizoma Dioscoreae 5, Fructus Litchi 8.5, Radix Salviae Miltiorrhizae 3, Radix Rehmanniae Preparata 4, Carnis Naemorhedi 10, Cortex Cinnamomi 4, Herba Boschniakiae Rossicae 12.5, Fructus Ligustri Lucidi 20, Tremella 15, Auricularia 10, Semen Nelumbinis 6.
4. improve the preparation method of the infertile compositions that endocrine disturbance causes according to claim 4, it is characterized in that: step is as follows:
1. Herba Leonuri, Radix Salviae Miltiorrhizae, Radix Rehmanniae Preparata, Cortex Cinnamomi, Herba Boschniakiae Rossicae and Fructus Ligustri Lucidi are cleaned up, be placed in marmite, add light salt brine, the ratio of salt and water is 1:3, and intense fire is fried open, and turns slow fire boiling 40-60 minute, filter, obtain filtrate, filtering residue adds light salt brine again, slow fire simmers 50-70 minute, filter, obtain filtrate, twice filtrate mixing, leave standstill 5-10 hour, obtain supernatant stand-by;
2. be divided into two by Fructus Jujubae, enucleation, removes the peel Rhizoma Dioscoreae, cleans, and mixes stand-by by the Fructus Jujubae handled well and Rhizoma Dioscoreae;
3. Herba Saussureae Involueratae, Tremella, Auricularia and Semen Nelumbinis are first clean by cold water flush, be placed in the bowl of porcelain, add the warm water of 30-40 DEG C, soak 20-40 minute, with strainer, soaked Herba Saussureae Involueratae, Tremella, Auricularia and Semen Nelumbinis are taken out, then rush with cold water stand-by;
4. thin slice Carnis Naemorhedi being cut into coin-size is placed in marmite, by step 1. gained supernatant join in marmite, big fire is boiled, until boiling 2-6 minute after add step 2.-3. gains and Fructus Litchi, slow fire simmers 60-120 minute slowly, filter, filtrate is bottled to obtain oral liquid, and it is edible that filtering residue can work as nutriment.
5. the preparation method of compositions according to claim 4, is characterized in that: step 1. intense fire is fried open, and turns slow fire boiling 45-55 minute (preferred, intense fire is fried open, and turns slow fire boiling 50 minutes).
6. the preparation method of compositions according to claim 4, is characterized in that: step 1. slow fire simmers 55-65 minute, filters, obtains filtrate, twice filtrate mixing, (preferred, slow fire simmers 60 minutes, filters to leave standstill 6-9 hour, obtain filtrate, twice filtrate mixing, leaves standstill 7.5 hours).
7. the preparation method of compositions according to claim 4, is characterized in that: 3. step adds the warm water of 33-38 DEG C, soaks 25-35 minute (preferred, to add the warm water of 35 DEG C, soak 30 minutes).
8. the preparation method of compositions according to claim 4, is characterized in that: step 4. until boiling add after 3-5 minute step 2.-3. gains (preferred, until boiling add after 4 minutes step 2.-3. gains).
9. the preparation method of compositions according to claim 4, is characterized in that: step 4. slow fire is simmered 80-100 minute (preferred, slow fire simmers 90 minutes slowly) slowly.
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| CN108042782A (en) * | 2018-01-16 | 2018-05-18 | 郭颖 | Infertile Chinese medicine composition and preparation method thereof caused by a kind of improvement endocrine disorder |
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