CN105106869A - Traditional Chinese medicine composition for treating melanoma and preparation method of traditional Chinese medicine composition - Google Patents

Traditional Chinese medicine composition for treating melanoma and preparation method of traditional Chinese medicine composition Download PDF

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CN105106869A
CN105106869A CN201510640743.XA CN201510640743A CN105106869A CN 105106869 A CN105106869 A CN 105106869A CN 201510640743 A CN201510640743 A CN 201510640743A CN 105106869 A CN105106869 A CN 105106869A
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radix
herba
chinese medicine
ethanol
semen
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不公告发明人
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Qingdao You Cheng New And High Technology Co Ltd
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Qingdao You Cheng New And High Technology Co Ltd
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Abstract

The invention relates to the field of traditional Chinese medicine, in particular to a traditional Chinese medicine composition for treating melanoma. The traditional Chinese medicine composition consists of mistletoe, kadsura longepedunculata, oldenlandia diffusa, spina gleditsiae, angelica, garden balsam seeds, peach kernels, morinda officinalis, mulberry leaves, medlar, honeysuckle, bighead atractylodes rhizome, day lily, rhubarb, tuckahoe, chrysosplenium, ixeris chinensis nakai, felwort, herba scutellariae barbatae, radix zanthoxyli, endothelium corneum gigeriae galli, shelled cedar seeds, pomegranate bark, wild yellow roots, astragalus roots, rhizoma gastrodiae, wild jujube seeds, lycopodium clavatum and the like. Compared with the prior art, the traditional Chinese medicine composition has the advantages of good curative effect, low cost, small limitation, no side effect and the like. The medicine provided by the invention can enhance the body immunity, can inhibit the melanoma growth, and does not have obvious side effects, so that positive significance is achieved on the improvement of the immunologic function of a chemotherapy patient and the improvement of life quality, and the large-range clinical popularization and application can be conveniently realized.

Description

One treats melanomatous Chinese medicine composition and preparation method thereof
Technical field
The invention belongs to technical field of traditional Chinese pharmacology, be specifically related to one and treat melanomatous Chinese medicine composition and preparation method thereof.
Background technology
Melanocytoma can by epidermal melanocytes, nevus cell or corium melanoblast composition.Tumor originates is in deric neural crest, and melanocyte is positioned between epidermal area and basal cell and arranges, and after cell chromogenesis, is transported in basal cell and hair by melanin granule by tree-shaped dashing forward.The true cause that Normal melanocytes tumor becomes it be unclear that, may be relevant with following factors:
Optimum melanin speckle and melanotic nevus, wherein junctional nevus the most easily cancerates, and compound nevus is less, and endothelium nevus is then seldom cancerated.But scalp melanoma majority not melanotic nevus changes, therefore primary disease is not exclusively relevant with melanotic nevus to have people to think.Sunlight and ultraviolet radiation scalp melanoma are more common in exposure position, and according to Israel's statistics, the annual morbidity 15.4/10 ten thousand of agriculture labourer, comparatively city person is high, and the resident living in coastal area is then high than living in mountain area person.Since the eighties in 20th century, melanoma sickness rate increases by more than 1 times, estimates to be subject to ultraviolet excessive radiation with Atmospheric Ozone Layer Depletion and skin relevant.
Melanoma is by caused by intraepidermal melanocytic hyperplasia, and it shows as the dense tuberosity increased gradually of pigment, around can around with blush.Though its sickness rate comparatively basal cell carcinoma, squamous cell carcinoma is low, grade of malignancy is large, and transfer occurs early, and mortality rate is high.The traditional Chinese medical science is to melanomatous treatment, and " Waike Zhengzong, Orthodox Manual of External Diseases " of Ming Dynasty's Chen Shigong is discussed the most detailed.Later ancient Chinese medicine doctor, particularly modern age doctor determine in a large amount of clinical practice for oral administration combine with external treatment distinguish the pattern of controlling, illustrate Chinese medicine melanoma and really can improve symptom, life-saving, the effect of raising life quality.
Summary of the invention
In order to overcome deficiency of the prior art, the invention provides one and treating melanomatous Chinese medicine composition, to melanoma, there is significant curative effect.
In order to solve the problems of the technologies described above, the technical solution used in the present invention is as follows: one treats melanomatous Chinese medicine composition, is made up of each component of following parts by weight:
Herba Taxilli, Fructus Schisandrae Sphenantherae, Herba Hedyotidis Diffusae, Spina Gleditsiae, Radix Angelicae Sinensis, Semen Impatientis, Semen Persicae, Radix Morindae Officinalis, Folium Mori, Fructus Lycii, Flos Lonicerae, the Rhizoma Atractylodis Macrocephalae, Hemerocallis fulva L., Radix Et Rhizoma Rhei, Poria, Chrysosplenium nudicaule Bunge, Herba Ixeritis Denticulatae, Radix Gentianae, Herba Scutellariae Barbatae, Radix Zanthoxyli, Endothelium Corneum Gigeriae Galli, Semen Platycladi, Pericarpium Granati, Rhizoma Curcumae Longae, the Radix Astragali, Rhizoma Gastrodiae, Semen Ziziphi Spinosae, Herba Lycopodii.
As preferably, the present invention is made up of each component of following parts by weight:
Herba Taxilli 1-30 part, Fructus Schisandrae Sphenantherae 1-30 part, Herba Hedyotidis Diffusae 1-30 part, Spina Gleditsiae 1-30 part, Radix Angelicae Sinensis 1-30 part, Semen Impatientis 1-30 part, Semen Persicae 1-30 part, Radix Morindae Officinalis 1-30 part, Folium Mori 1-30 part, Fructus Lycii 1-30 part, Flos Lonicerae 1-30 part, Rhizoma Atractylodis Macrocephalae 1-30 part, Hemerocallis fulva L. 1-30 part, Radix Et Rhizoma Rhei 1-30 part, Poria 1-30 part, Chrysosplenium nudicaule Bunge 1-30 part, Herba Ixeritis Denticulatae 1-30 part, Radix Gentianae 1-30 part, Herba Scutellariae Barbatae 1-30 part, Radix Zanthoxyli 1-30 part, Endothelium Corneum Gigeriae Galli 1-30 part, Semen Platycladi 1-30 part, Pericarpium Granati 1-30 part, Rhizoma Curcumae Longae 1-30 part, Radix Astragali 1-30 part, Rhizoma Gastrodiae 1-30 part, Semen Ziziphi Spinosae 1-30 part, Herba Lycopodii 1-30 part.
As preferably, the present invention is made up of each component of following parts by weight:
Herba Taxilli 1-15 part, Fructus Schisandrae Sphenantherae 1-15 part, Herba Hedyotidis Diffusae 1-15 part, Spina Gleditsiae 1-15 part, Radix Angelicae Sinensis 1-15 part, Semen Impatientis 1-15 part, Semen Persicae 1-15 part, Radix Morindae Officinalis 1-15 part, Folium Mori 1-15 part, Fructus Lycii 1-15 part, Flos Lonicerae 1-15 part, Rhizoma Atractylodis Macrocephalae 1-15 part, Hemerocallis fulva L. 1-15 part, Radix Et Rhizoma Rhei 1-15 part, Poria 1-15 part, Chrysosplenium nudicaule Bunge 1-15 part, Herba Ixeritis Denticulatae 1-15 part, Radix Gentianae 1-15 part, Herba Scutellariae Barbatae 1-15 part, Radix Zanthoxyli 1-15 part, Endothelium Corneum Gigeriae Galli 1-15 part, Semen Platycladi 1-15 part, Pericarpium Granati 1-15 part, Rhizoma Curcumae Longae 1-15 part, Radix Astragali 1-15 part, Rhizoma Gastrodiae 1-15 part, Semen Ziziphi Spinosae 1-15 part, Herba Lycopodii 1-15 part.
As preferably, the present invention also comprises each component composition of following parts by weight: Cycas revoluta 1-15 part.
As preferably, the present invention also comprises each component composition of following parts by weight: Ganoderma 1-15 part, Bufo siccus 1-15 part.
As preferably, the dosage form of Chinese medicine preparation of the present invention is: sublimed preparation, powder, injection, plaster, syrup, oral liquid, suck agent, granule, sugar coated tablet, film coated tablet, capsule.
As preferably, present invention also offers a kind of preparation method for the treatment of melanomatous Chinese medicine composition, preparation comprises the following steps:
(1) by Herba Taxilli, Fructus Schisandrae Sphenantherae, Herba Hedyotidis Diffusae, Spina Gleditsiae, Radix Angelicae Sinensis, Semen Impatientis, Semen Persicae, Radix Morindae Officinalis, clean, put into container, add 80% ethanol of 1-10 times amount, at 60-100 DEG C of alcoholization 50-120 minute, add the water of 6 times amount again, 75 DEG C of insulations 100 minutes, concentration and recovery ethanol, obtained mixed liquor, filter mixed liquor obtains filtrate, and the Chinese medicine residue of filtration repeats above extraction step; Merge twice filtrate, with aperture at 1000um, molecular cut off is in the high temperature resistant high rejection rolling NF membrane of 300KDalton, isolate the large particulate matter in filtrate and supernatant, supernatant concentration, at simmer down to 60 DEG C, relative density is the thick paste of 1.10 ~ 1.14 and dry, pulverize powdered, for subsequent use;
(2) by Folium Mori, the Rhizoma Atractylodis Macrocephalae, Hemerocallis fulva L., Radix Et Rhizoma Rhei, Poria, Chrysosplenium nudicaule Bunge, Herba Ixeritis Denticulatae, Radix Gentianae, Radix Zanthoxyli, Endothelium Corneum Gigeriae Galli, clean, put into container, add 1-8 times amount 80% ethanol, drop in microwave extracting apparatus and carry out microwave extracting, extraction power 1000W, extracts 3 times, each 30 minutes, combining extraction liquid, concentrated, be added on DiaionHP-10 macroporous adsorptive resins, 80% ethanol elution, collect 4 times amount column volume eluents, decompression recycling ethanol, concentrated and dry, obtain microwave extraction thing, for subsequent use;
(3) by Semen Platycladi, Pericarpium Granati, Rhizoma Curcumae Longae, the Radix Astragali, Rhizoma Gastrodiae, Herba Lycopodii, Cycas revoluta, Herba Scutellariae Barbatae, Ganoderma, Bufo siccus, CO is joined 2in supercritical extraction device, ethanol is as entrainer, and the percent by volume that entrainer accounts for total extractant is 8%, extracting pressure 20-30MPa, temperature 60 C, CO 2flow 4ml/g crude drug min, extraction time 120min, obtains supercritical extract, for subsequent use;
(4) Flos Lonicerae, Semen Ziziphi Spinosae, Fructus Lycii are mixed, carry out pulverization process after mix homogeneously, grind into powder, cross 200 order fine powders, for subsequent use;
(5) by above-mentioned steps (1), (4) gained mix homogeneously, crossing 200 mesh sieves, is then that 25mg/100g adds volume fraction 80% ethanol according to mass ratio, wet granulation, grain graininess 25 order, by obtained granule in 70 DEG C of dry 12h, for subsequent use; Then in the obtained microwave extraction thing of step (2), step (3) and supercritical extract, add the dextrin of 20-40%, mix homogeneously, then be that 20ml/100g adds volume fraction 95% ethanol according to concentration, make soft material, cross 20 mesh sieves, granulate, grain graininess 25 order, in 80 DEG C of dry 120min, for subsequent use; By above-mentioned two kinds of granule mix homogeneously, add excipient substance, be prepared into corresponding pharmaceutical dosage form.。
As preferably, tablet preparation of the present invention comprises the following steps:
(1) by Herba Taxilli, Fructus Schisandrae Sphenantherae, Herba Hedyotidis Diffusae, Spina Gleditsiae, Radix Angelicae Sinensis, Semen Impatientis, Semen Persicae, Radix Morindae Officinalis, clean, put into container, add 80% ethanol of 1-10 times amount, at 60-100 DEG C of alcoholization 50-120 minute, add the water of 6 times amount again, 75 DEG C of insulations 100 minutes, concentration and recovery ethanol, obtained mixed liquor, filter mixed liquor obtains filtrate, and the Chinese medicine residue of filtration repeats above extraction step; Merge twice filtrate, with aperture at 1000um, molecular cut off is in the high temperature resistant high rejection rolling NF membrane of 300KDalton, isolate the large particulate matter in filtrate and supernatant, supernatant concentration, at simmer down to 60 DEG C, relative density is the thick paste of 1.10 ~ 1.14 and dry, pulverize powdered, for subsequent use;
(2) by Folium Mori, the Rhizoma Atractylodis Macrocephalae, Hemerocallis fulva L., Radix Et Rhizoma Rhei, Poria, Chrysosplenium nudicaule Bunge, Herba Ixeritis Denticulatae, Radix Gentianae, Radix Zanthoxyli, Endothelium Corneum Gigeriae Galli, clean, put into container, add 1-8 times amount 80% ethanol, drop in microwave extracting apparatus and carry out microwave extracting, extraction power 1000W, extracts 3 times, each 30 minutes, combining extraction liquid, concentrated, be added on DiaionHP-10 macroporous adsorptive resins, 80% ethanol elution, collect 4 times amount column volume eluents, decompression recycling ethanol, concentrated and dry, obtain microwave extraction thing, for subsequent use;
(3) by Semen Platycladi, Pericarpium Granati, Rhizoma Curcumae Longae, the Radix Astragali, Rhizoma Gastrodiae, Herba Lycopodii, Cycas revoluta, Herba Scutellariae Barbatae, Ganoderma, Bufo siccus, CO is joined 2in supercritical extraction device, ethanol is as entrainer, and the percent by volume that entrainer accounts for total extractant is 8%, extracting pressure 20-30MPa, temperature 60 C, CO 2flow 4ml/g crude drug min, extraction time 120min, obtains supercritical extract, for subsequent use;
(4) Flos Lonicerae, Semen Ziziphi Spinosae, Fructus Lycii are mixed, carry out pulverization process after mix homogeneously, grind into powder, cross 200 order fine powders, for subsequent use;
(5) by above-mentioned steps (1), (4) gained mix homogeneously, crossing 200 mesh sieves, is then that 25mg/100g adds volume fraction 80% ethanol according to mass ratio, wet granulation, grain graininess 25 order, by obtained granule in 70 DEG C of dry 12h, for subsequent use; Then in the obtained microwave extraction thing of step (2), step (3) and supercritical extract, add the dextrin of 20-40%, mix homogeneously, then be that 20ml/100g adds volume fraction 95% ethanol according to concentration, make soft material, cross 20 mesh sieves, granulate, grain graininess 25 order, in 80 DEG C of dry 120min, for subsequent use; By above-mentioned two kinds of granule mix homogeneously, add magnesium stearate and carry out tabletting, be prepared into medicinal tablet.
Theoretical foundation of the present invention:
Herba Taxilli: nature and flavor: bitter sweet is flat.1. " herbal classic ": " bitter, flat." 2. " not Lu ": " be sweet, nontoxic." 3. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " slightly warm in nature, bitter but sweet flavor." return through: enter liver, kidney channel.1. " book on Chinese herbal medicine must be joined ": " enter meridian of Foot-JUE YIN." 2. " book on Chinese herbal medicine is looked for the truth ": " enters liver, kidney." 3. " book on Chinese herbal medicine is new again ": " enters the heart, kidney two warp." function cures mainly: invigorating the liver and kidney, bone and muscle strengthening, except rheumatism, and the meridian dredging, beneficial blood, antiabortive.Control soreness of waist and knee joint, muscles and bones flaccidity is weak, hemiplegia, beriberi, anemofrigid-damp arthralgia, vaginal bleeding during pregnancy metrorrhagia, lack of lactation after delivery.
Fructus Schisandrae Sphenantherae: nature and flavor: sour, sweet, temperature.Gui Jing: return lung, the heart, kidney channel.Function cures mainly: restrain astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, kidney calming.For chronic cough dyspnea due to deficiency, emission, enuresis frequent micturition, incessant chronic diarrhea, spontaneous perspiration, night sweat, Tianjin wound is thirsty, and deficient pulse of losing heart, interior-heat is quenched one's thirst, palpitation and insomnia.
Herba Hedyotidis Diffusae: nature and flavor: bitter sweet, cold.1. " " western Chinese medicinal herbal ": " bitter but sweet flavor, warm in nature, nontoxic." 2. " the south of Fujian Province traditional herbal medicine ": " is bitter, flat, nontoxic." 3. " Quanzhou book on Chinese herbal medicine ": " sweet micro-acid, cold in nature." 4. " Guangdong Chinese medicine " II: " is pungent puckery, cold, nontoxic." return through: " Guangxi Chinese medicinal herbal ": " enters the heart, liver, spleen three warp." function cures mainly: heat clearing away, dampness removing, removing toxic substances.Control dyspnea and cough due to lung-heat, tonsillitis.Pharyngolaryngitis, appendicitis, dysentery, urinary tract infection, jaundice, hepatitis, pelvic inflammatory disease, adnexitis, carbuncle furuncle, venom, tumor.Also can be used for alimentary tract cancer.
Spina Gleditsiae: draw out pus by applying a plaster to the affected part and dispel the wind.The non-one-tenth person of all carbuncle, can draw to dissipate, will the person of breaking, can draw to lift one's head, routed person can draw with row pus.Be first want agent in infections poison.Let out again blood apoplexy hot blast poison, therefore also push away this medicine in strict wind medicine for convincing forward by patient analysis also.Shen Shi says, and it is good that Fructus Gleditsia acupuncture should sting the sharp person of pole tip with head, the lower joint of thorn (stalk) person as hard in branch, power thin too late also.Yao Jiyuan cloud, controls leprosy leprosy disease, tinea corporis wind skin ulcer, and wind of scratching where it itches is considered to be worth doing, use same with Radix Sophorae Flavescentis, and its power more doubly.
Radix Angelicae Sinensis: nature and flavor: sweet, acrid, warm.Gui Jing: return liver, the heart, spleen channel.Function cures mainly: enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.For blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.Radix Angelicae Sinensis (processed with wine) promoting blood circulation to restore menstrual flow.For amenorrhea dysmenorrhea, rheumatic arthralgia, injury from falling down.
Semen Impatientis: nature and flavor: toil, temperature, poisonous.1. " detailed outline ": " micro-hardship, temperature, slightly poisonous." 2. " medical center bun is wanted ": " is pungent, flat." 3. " book on Chinese herbal medicine is new again ": " bitter in the mouth is pungent, cool in nature, poisonous." return through: 1. " beautiful Chinese catalpa medicine solution ": " enters kidney meridian." 2. " book on Chinese herbal medicine is new again ": " enters liver, lung two warp." function cures mainly: removing blood stasis, removing food stagnancy, softening the hard mass.Control amenorrhea, long-pending block, dysphagic, outer infections heavily fortified point is swollen, a fishbone or other bone caught in the throat not under.
Semen Persicae: nature and flavor: bitter sweet is flat.1. " herbal classic ": " bitter in the mouth is flat." 2. " not Lu ": " be sweet, nontoxic." 3. " a thousand pieces of gold dietetic therapy ": " bitter but sweet flavor is pungent, flat, nontoxic." return through: enter the heart, liver, large intestine channel.Function cures mainly: blood stasis removing and clots absorbing, moisturizes laxation.Control amenorrhea, lump in the abdomen, calentura blood-retention, migratory arthralgia, malaria, traumatic injury, swelling and pain due to blood stasis, the dry constipation of blood.
Radix Morindae Officinalis: nature and flavor: Xin Gan, temperature.1. " herbal classic ": " acrid in the mouth, tepor." 2. " not Lu ": " be sweet, nontoxic." 3. " Japan hanako materia medica ": " bitter in the mouth." return through: enter liver, kidney channel.Function cures mainly: kidney-replenishing, strengthening bone and muscle, wind-damp dispelling.Control sexual impotence, few abdomen cold type of pain, incontinence of urine, deficiency-cold of uterus, anemofrigid-damp arthralgia, soreness of waist and knee joint.
Folium Mori: nature and flavor: bitter sweet, cold.1. " Japan hanako materia medica ": " warm, nontoxic." 2. " detailed outline ": " bitter but sweet flavor, cold, slightly poisonous." 3. " medical center bun is wanted ": " is sweet misery, cold." return through: enter lung, Liver Channel.Function cures mainly: expelling wind and clearing away heat, cooling blood for improving eyesight.Control pathogenic wind-warm heating, headache, conjunctival congestion, thirsty, cough due to lung-heat, migratory arthralgia, urticaria, lower limb elephatiasis.
Fructus Lycii: nature and flavor: sweet, flat.1. " not Lu ": " be slightly cold, nontoxic." 2. " property of medicine opinion ": " sweet in the mouth is flat." 3. " Treatise on Dietetic Therapy ": " trembles with fear, nontoxic." return through: enter liver, kidney channel.Function cures mainly: nourishing kidney, lung moistening, tonifying liver, improving eyesight.Control hepatic and renal YIN deficiency, soreness of the waist and knees, dizzy, dizzy, the many tear of blurred vision, cough due to consumptive disease, quenches one's thirst, seminal emission.
Flos Lonicerae: nature and flavor: sweet, cold.1. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " cold in nature, bitter in the mouth." 2. " book on Chinese herbal medicine just ": " sweet in the mouth, gas is put down, its cold nature." return through: enter lung, stomach warp.1. " Thunder God concocts property of medicine solution ": " enter lung meridian." 2. " must join book on Chinese herbal medicine ": " enters bright, the Taiyin channels of foot sun." function cures mainly: heat clearing away, removing toxic substances.Control epidemic febrile disease heating, toxic-heat and blood stasis, carbuncle and ulcer, toxic swelling, scrofula, anal fistula.
The Rhizoma Atractylodis Macrocephalae: nature and flavor: bitter, sweet, temperature.Gui Jing: return spleen, stomach warp.Function cures mainly: invigorating the spleen and benefiting QI, dampness diuretic, and hidroschesis is antiabortive.For insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.Rhizoma Atractylodis Macrocephalae spleen invigorating, stomach function regulating, antiabortive.For insufficiency of the spleen lack of appetite, loose stool of having loose bowels, frequent fetal movement.
Hemerocallis fulva L.: nature and flavor: sweet is cool.Function cures mainly: clearing away heat and promoting diuresis, cooling blood for hemostasis.For parotitis, jaundice, cystitis, hematuria, dysuria, agalactosis, menoxenia, epistaxis, has blood in stool.Mastitis are controlled in external.
Radix Et Rhizoma Rhei: nature and flavor: bitter, cold.Gui Jing: return spleen, stomach, large intestine, liver, pericardium channel.Function cures mainly: purging heat and dredging bowels, removing pathogenic heat from blood and toxic substance from the body, eliminating blood stasis and inducing menstruation.For excess-heat constipation, stagnant stomachache, dysentery is not well, jaundice due to damp-heat, and heat in blood tells nosebleed, conjunctival congestion, pharyngeal swelling, abdominalgia with intestinal abscess, carbuncle furuncle, blood stasis amenorrhea, traumatic injury, external treatment burn due to hot liquid or fire; Upper gastrointestinal hemorrhage.Radix et Rhizoma Rhei (stir-fried with wine) is apt to clear part of the body cavity above the diaphragm housing the heart and lungs noxious heat in the blood system.For conjunctival congestion pharyngeal swelling, gingivitis.Radix Et Rhizoma Rhei rushes down exerts oneself to delay, eliminating fire and detoxication.For pathogenic fire,toxin and furuncles.Charred Radix Et Rhizoma Rhei cooling blood and removing stasis stops blooding.Stasis of blood hemorrhage is had for heat in blood.
Poria: nature and flavor: sweet, light is flat.Gui Jing: GUIXIN, lung, spleen, kidney channel.Function cures mainly: promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming.For edema oliguria, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in loose stool, irritability, palpitation with fear insomnia.
Chrysosplenium nudicaule Bunge: removing impurity.Nature and flavor: cold in nature, bitter in the mouth.Effect: clearing heat secreting bile, under cathartic.For gallbladder-heat disease, fever, headache, cholecystitis, cholelithiasis, for rushing down gallbladder-heat disease common drug.
Herba Ixeritis Denticulatae: nature and flavor: bitter, cool.1. " praise and help book on Chinese herbal medicine ": be " cold, nontoxic." 2. " Shaanxi Chinese herbal medicine ": " is bitter, cool." function cures mainly: control lung abscess, acute mastitis, stranguria with blood, furuncle and phyma, traumatic injury.1. " praise and help book on Chinese herbal medicine ": " control appearance Huang, powerful only tired, deposited snakeworm stings.Juice dressing treatment swells again, and namely root goes out." 2. " Shaanxi Chinese herbal medicine ": " heat clearing away, removing toxic substances, detumescence.Control innominate toxic swelling, acute mastitis, furuncle and phyma.3. " Wenling county drug resource register ": " refreshing and detoxicating, eliminating carbuncle eliminating stagnation.Control venom, lung abscess, furuncle and phyma, traumatic injury."
Radix Gentianae: nature and flavor: bitter, cold.Gui Jing: return liver, gallbladder meridian.Function cures mainly: heat clearing and damp drying, eliminating pathogen in the liver gallbladder fire.For jaundice due to damp-heat, swelling of the vulva pudendal pruritus, leukorrhagia, persistent erection of the penis, eczema pruritus, conjunctival congestion, deaf, hypochondriac pain, bitter taste, convulsion with spasms.
Herba Scutellariae Barbatae: nature and flavor: pungent, bitter, cold.Gui Jing: return lung, liver, kidney channel.Function cures mainly: heat-clearing and toxic substances removing, blood stasis dispelling diuresis.For furuncle swelling toxin, laryngopharynx swelling and pain, venom, falls and flutters the pain of injury, edema, jaundice.
Radix Zanthoxyli: nature and flavor: bitter, pungent, flat; Slightly poisonous.Gui Jing: return liver, stomach warp.Function cures mainly: promoting the circulation of QI to relieve pain, blood circulation promoting and blood stasis dispelling, dispelling wind and removing obstruction in the collateral.The traumatic injury caused for qi depression to blood stasis, rheumatic arthralgia, stomachache, toothache, venom; The burning hot wound of external treatment soup.
Endothelium Corneum Gigeriae Galli: nature and flavor: sweet is flat.Gui Jing: return spleen, stomach, small intestinal, urinary bladder channel.Function cures mainly: invigorating the stomach and promoting digestion, arresting seminal emission.Do not disappear for food stagnation, vomiting dysentery, infantile malnutrition, the enuresis, seminal emission.
Semen Platycladi: nature and flavor: sweet is flat.Gui Jing: GUIXIN, kidney, large intestine channel.Function cures mainly: tranquilizing by nourishing the heart, hidroschesis, intestine moistening.For fidgets due to deficiency insomnia, severe palpitation, night sweat due to yin deficiency, dryness of the intestine constipation.
Pericarpium Granati: nature and flavor: sour, puckery, temperature.Gui Jing: return large intestine channel.Function cures mainly: relieving diarrhea with astringents, hemostasis, anthelmintic.For chronic diarrhea, chronic dysentery, has blood in stool, proctoptosis, metrorrhagia, leucorrhea, abdominal pain due to worm stagnation.
Rhizoma Curcumae Longae: nature and flavor: pungent, bitter, temperature.Gui Jing: return spleen, Liver Channel.Function cures mainly: removing blood stasis circulation of qi promoting, inducing menstruation to relieve menalgia.Twinge for the breast side of body, amenorrhea , WEIJIA, rheumatism shoulder arm pain, tumbling and swelling.
The Radix Astragali: nature and flavor: sweet, temperature.Gui Jing: return lung, spleen channel.Function cures mainly: invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.Weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle difficulty is burst, and burst for a long time and do not hold back, blood deficiency dull yellowish colored skin, interior-heat is quenched one's thirst; Chronic nephritis proteinuria, diabetes.
Rhizoma Gastrodiae: nature and flavor: sweet is flat.Gui Jing: return Liver Channel.Function cures mainly: suppressing the hyperactive liver to relieve the wind syndrome relieving convulsion.Dizzy for having a headache, numb limbs and tense tendons, infantile convulsion, epilepsy clonus, tetanus.
Semen Ziziphi Spinosae: nature and flavor: sweet, sour is flat.Gui Jing: return liver, gallbladder, heart channel.Function cures mainly: tonifying liver, mind calming, and arresting sweating promotes the production of body fluid.For restlessness of asrhenia type and insomnia, palpitation with fear dreaminess, the empty hyperhidrosis of body, Tianjin wound is thirsty.
Herba Lycopodii: nature and flavor: micro-hardship, pungent, temperature.Gui Jing: return liver,spleen,kidney warp.Function cures mainly: expelling wind and removing dampness, relaxing muscles and tendons and activating QI and blood in the collateral.For joint aches, joint stuffiness.
Cycas revoluta: nature and flavor: sweet, light, flat.Function cures mainly: cooling blood for hemostasis, eliminating stasis to stop pain.For hemoptysis of pulmonary tuberculosis, epistaxis, hematuria, has blood in stool, bleeding hemorrhoids, menorrhagia, dysentery, stomachache, treating swelling and pain by traumatic injury.
Herba Scutellariae Barbatae: nature and flavor: pungent, bitter, cold.Gui Jing: return lung, liver, kidney channel.Function cures mainly: heat-clearing and toxic substances removing, blood stasis dispelling diuresis.For furuncle swelling toxin, laryngopharynx swelling and pain, venom, falls and flutters the pain of injury, edema, jaundice.
Ganoderma: nature and flavor: sweet, flat.Gui Jing: GUIXIN, lung, liver, kidney channel.Function cures mainly: invigorating QI and tranquilization, relieving cough and asthma.For dizzy sleeplessness, shortness of breath and palpitation, asthenia cough with asthma.
Bufo siccus: nature and flavor: pungent is cool, poisonous.Gui Jing: 1. " detailed outline ": " enter Yangming Channel." 2. " book on Chinese herbal medicine is new again ": " enters the heart, liver, spleen, lung four warp." function cures mainly: broken crux, row water wets, removing toxic substances, parasite killing, analgesic therapy.Control furuncle, carbuncle on the back, carbuncle of yin nature scrofula, malignant boil, the lump in the abdomen hypochondriac lump, tympanites, edema, infantile malnutrition, chronic tracheitis.
In sum, the present invention has the advantages such as good effect, cost is low, limitation is little, have no adverse reaction relative to prior art.Medicine of the present invention can enhancing human body immunity power, and check melanin tumor grows, and non-evident effect, this to improve patients undergoing chemotherapy immunologic function, improve life quality and have positive effect.Compare with similar drugs, it is rigorous that medicine of the present invention has compatibility, mild in medicine property and, feature evident in efficacy, treating both the principal and secondary aspects of a disease, is convenient to large scale application clinically.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is further elaborated.
Embodiment 1
The raw material composition of effective ingredient of the present invention and parts by weight are: Herba Taxilli 1 part, Fructus Schisandrae Sphenantherae 1 part, Herba Hedyotidis Diffusae 1 part, Spina Gleditsiae 1 part, Radix Angelicae Sinensis 1 part, Semen Impatientis 1 part, 5 parts, Semen Persicae, Radix Morindae Officinalis 2 parts, 1 part, Folium Mori, Fructus Lycii 2 parts, Flos Lonicerae 2 parts, the Rhizoma Atractylodis Macrocephalae 1 part, Hemerocallis fulva L. 1 part, Radix Et Rhizoma Rhei 1 part, 1 part, Poria, Chrysosplenium nudicaule Bunge 1 part, Herba Ixeritis Denticulatae 1 part, Radix Gentianae 1 part, Herba Scutellariae Barbatae 1 part, Radix Zanthoxyli 1 part, Endothelium Corneum Gigeriae Galli 1 part, Semen Platycladi 2 parts, Pericarpium Granati 1 part, 1 part, Rhizoma Curcumae Longae, the Radix Astragali 2 parts, 1 part, Rhizoma Gastrodiae, Semen Ziziphi Spinosae 1 part, Herba Lycopodii 1 part.
Said medicine tablet preparation of the present invention comprises the following steps:
(1) by Herba Taxilli, Fructus Schisandrae Sphenantherae, Herba Hedyotidis Diffusae, Spina Gleditsiae, Radix Angelicae Sinensis, Semen Impatientis, Semen Persicae, Radix Morindae Officinalis, clean, put into container, add 80% ethanol of 1-10 times amount, at 60-100 DEG C of alcoholization 50-120 minute, add the water of 6 times amount again, 75 DEG C of insulations 100 minutes, concentration and recovery ethanol, obtained mixed liquor, filter mixed liquor obtains filtrate, and the Chinese medicine residue of filtration repeats above extraction step; Merge twice filtrate, with aperture at 1000um, molecular cut off is in the high temperature resistant high rejection rolling NF membrane of 300KDalton, isolate the large particulate matter in filtrate and supernatant, supernatant concentration, at simmer down to 60 DEG C, relative density is the thick paste of 1.10 ~ 1.14 and dry, pulverize powdered, for subsequent use;
(2) by Folium Mori, the Rhizoma Atractylodis Macrocephalae, Hemerocallis fulva L., Radix Et Rhizoma Rhei, Poria, Chrysosplenium nudicaule Bunge, Herba Ixeritis Denticulatae, Radix Gentianae, Radix Zanthoxyli, Endothelium Corneum Gigeriae Galli, clean, put into container, add 1-8 times amount 80% ethanol, drop in microwave extracting apparatus and carry out microwave extracting, extraction power 1000W, extracts 3 times, each 30 minutes, combining extraction liquid, concentrated, be added on DiaionHP-10 macroporous adsorptive resins, 80% ethanol elution, collect 4 times amount column volume eluents, decompression recycling ethanol, concentrated and dry, obtain microwave extraction thing, for subsequent use;
(3) by Semen Platycladi, Pericarpium Granati, Rhizoma Curcumae Longae, the Radix Astragali, Rhizoma Gastrodiae, Herba Lycopodii, Herba Scutellariae Barbatae, CO is joined 2in supercritical extraction device, ethanol is as entrainer, and the percent by volume that entrainer accounts for total extractant is 8%, extracting pressure 20-30MPa, temperature 60 C, CO 2flow 4ml/g crude drug min, extraction time 120min, obtains supercritical extract, for subsequent use;
(4) Flos Lonicerae, Semen Ziziphi Spinosae, Fructus Lycii are mixed, carry out pulverization process after mix homogeneously, grind into powder, cross 200 order fine powders, for subsequent use;
(5) by above-mentioned steps (1), (4) gained mix homogeneously, crossing 200 mesh sieves, is then that 25mg/100g adds volume fraction 80% ethanol according to mass ratio, wet granulation, grain graininess 25 order, by obtained granule in 70 DEG C of dry 12h, for subsequent use; Then in the obtained microwave extraction thing of step (2), step (3) and supercritical extract, add the dextrin of 20-40%, mix homogeneously, then be that 20ml/100g adds volume fraction 95% ethanol according to concentration, make soft material, cross 20 mesh sieves, granulate, grain graininess 25 order, in 80 DEG C of dry 120min, for subsequent use; By above-mentioned two kinds of granule mix homogeneously, add magnesium stearate and carry out tabletting, be prepared into medicinal tablet.
Embodiment 2
The raw material composition of effective ingredient of the present invention and parts by weight are: Herba Taxilli 1 part, Fructus Schisandrae Sphenantherae 1 part, Herba Hedyotidis Diffusae 1 part, Spina Gleditsiae 1 part, Radix Angelicae Sinensis 1 part, Semen Impatientis 1 part, 5 parts, Semen Persicae, Radix Morindae Officinalis 2 parts, 1 part, Folium Mori, Fructus Lycii 2 parts, Flos Lonicerae 2 parts, the Rhizoma Atractylodis Macrocephalae 1 part, Hemerocallis fulva L. 1 part, Radix Et Rhizoma Rhei 1 part, 1 part, Poria, Chrysosplenium nudicaule Bunge 1 part, Herba Ixeritis Denticulatae 1 part, Radix Gentianae 1 part, Herba Scutellariae Barbatae 1 part, Radix Zanthoxyli 1 part, Endothelium Corneum Gigeriae Galli 1 part, Semen Platycladi 2 parts, Pericarpium Granati 1 part, 1 part, Rhizoma Curcumae Longae, the Radix Astragali 2 parts, 1 part, Rhizoma Gastrodiae, Semen Ziziphi Spinosae 1 part, Herba Lycopodii 1 part, Cycas revoluta 1 part.
Said medicine tablet preparation of the present invention comprises the following steps:
(1) by Herba Taxilli, Fructus Schisandrae Sphenantherae, Herba Hedyotidis Diffusae, Spina Gleditsiae, Radix Angelicae Sinensis, Semen Impatientis, Semen Persicae, Radix Morindae Officinalis, clean, put into container, add 80% ethanol of 1-10 times amount, at 60-100 DEG C of alcoholization 50-120 minute, add the water of 6 times amount again, 75 DEG C of insulations 100 minutes, concentration and recovery ethanol, obtained mixed liquor, filter mixed liquor obtains filtrate, and the Chinese medicine residue of filtration repeats above extraction step; Merge twice filtrate, with aperture at 1000um, molecular cut off is in the high temperature resistant high rejection rolling NF membrane of 300KDalton, isolate the large particulate matter in filtrate and supernatant, supernatant concentration, at simmer down to 60 DEG C, relative density is the thick paste of 1.10 ~ 1.14 and dry, pulverize powdered, for subsequent use;
(2) by Folium Mori, the Rhizoma Atractylodis Macrocephalae, Hemerocallis fulva L., Radix Et Rhizoma Rhei, Poria, Chrysosplenium nudicaule Bunge, Herba Ixeritis Denticulatae, Radix Gentianae, Radix Zanthoxyli, Endothelium Corneum Gigeriae Galli, clean, put into container, add 1-8 times amount 80% ethanol, drop in microwave extracting apparatus and carry out microwave extracting, extraction power 1000W, extracts 3 times, each 30 minutes, combining extraction liquid, concentrated, be added on DiaionHP-10 macroporous adsorptive resins, 80% ethanol elution, collect 4 times amount column volume eluents, decompression recycling ethanol, concentrated and dry, obtain microwave extraction thing, for subsequent use;
(3) by Semen Platycladi, Pericarpium Granati, Rhizoma Curcumae Longae, the Radix Astragali, Rhizoma Gastrodiae, Herba Lycopodii, Cycas revoluta, Herba Scutellariae Barbatae, CO is joined 2in supercritical extraction device, ethanol is as entrainer, and the percent by volume that entrainer accounts for total extractant is 8%, extracting pressure 20-30MPa, temperature 60 C, CO 2flow 4ml/g crude drug min, extraction time 120min, obtains supercritical extract, for subsequent use;
(4) Flos Lonicerae, Semen Ziziphi Spinosae, Fructus Lycii are mixed, carry out pulverization process after mix homogeneously, grind into powder, cross 200 order fine powders, for subsequent use;
(5) by above-mentioned steps (1), (4) gained mix homogeneously, crossing 200 mesh sieves, is then that 25mg/100g adds volume fraction 80% ethanol according to mass ratio, wet granulation, grain graininess 25 order, by obtained granule in 70 DEG C of dry 12h, for subsequent use; Then in the obtained microwave extraction thing of step (2), step (3) and supercritical extract, add the dextrin of 20-40%, mix homogeneously, then be that 20ml/100g adds volume fraction 95% ethanol according to concentration, make soft material, cross 20 mesh sieves, granulate, grain graininess 25 order, in 80 DEG C of dry 120min, for subsequent use; By above-mentioned two kinds of granule mix homogeneously, add magnesium stearate and carry out tabletting, be prepared into medicinal tablet.
Embodiment 3
The raw material composition of effective ingredient of the present invention and parts by weight are: Herba Taxilli 1 part, Fructus Schisandrae Sphenantherae 1 part, Herba Hedyotidis Diffusae 1 part, Spina Gleditsiae 1 part, Radix Angelicae Sinensis 1 part, Semen Impatientis 1 part, 5 parts, Semen Persicae, Radix Morindae Officinalis 2 parts, 1 part, Folium Mori, Fructus Lycii 2 parts, Flos Lonicerae 2 parts, the Rhizoma Atractylodis Macrocephalae 1 part, Hemerocallis fulva L. 1 part, Radix Et Rhizoma Rhei 1 part, 1 part, Poria, Chrysosplenium nudicaule Bunge 1 part, Herba Ixeritis Denticulatae 1 part, Radix Gentianae 1 part, Herba Scutellariae Barbatae 1 part, Radix Zanthoxyli 1 part, Endothelium Corneum Gigeriae Galli 1 part, Semen Platycladi 2 parts, Pericarpium Granati 1 part, 1 part, Rhizoma Curcumae Longae, the Radix Astragali 2 parts, 1 part, Rhizoma Gastrodiae, Semen Ziziphi Spinosae 1 part, Herba Lycopodii 1 part, Cycas revoluta 1 part, Ganoderma 1 part, Bufo siccus 1 part.
Said medicine tablet preparation of the present invention comprises the following steps:
(1) by Herba Taxilli, Fructus Schisandrae Sphenantherae, Herba Hedyotidis Diffusae, Spina Gleditsiae, Radix Angelicae Sinensis, Semen Impatientis, Semen Persicae, Radix Morindae Officinalis, clean, put into container, add 80% ethanol of 1-10 times amount, at 60-100 DEG C of alcoholization 50-120 minute, add the water of 6 times amount again, 75 DEG C of insulations 100 minutes, concentration and recovery ethanol, obtained mixed liquor, filter mixed liquor obtains filtrate, and the Chinese medicine residue of filtration repeats above extraction step; Merge twice filtrate, with aperture at 1000um, molecular cut off is in the high temperature resistant high rejection rolling NF membrane of 300KDalton, isolate the large particulate matter in filtrate and supernatant, supernatant concentration, at simmer down to 60 DEG C, relative density is the thick paste of 1.10 ~ 1.14 and dry, pulverize powdered, for subsequent use;
(2) by Folium Mori, the Rhizoma Atractylodis Macrocephalae, Hemerocallis fulva L., Radix Et Rhizoma Rhei, Poria, Chrysosplenium nudicaule Bunge, Herba Ixeritis Denticulatae, Radix Gentianae, Radix Zanthoxyli, Endothelium Corneum Gigeriae Galli, clean, put into container, add 1-8 times amount 80% ethanol, drop in microwave extracting apparatus and carry out microwave extracting, extraction power 1000W, extracts 3 times, each 30 minutes, combining extraction liquid, concentrated, be added on DiaionHP-10 macroporous adsorptive resins, 80% ethanol elution, collect 4 times amount column volume eluents, decompression recycling ethanol, concentrated and dry, obtain microwave extraction thing, for subsequent use;
(3) by Semen Platycladi, Pericarpium Granati, Rhizoma Curcumae Longae, the Radix Astragali, Rhizoma Gastrodiae, Herba Lycopodii, Cycas revoluta, Herba Scutellariae Barbatae, Ganoderma, Bufo siccus, CO is joined 2in supercritical extraction device, ethanol is as entrainer, and the percent by volume that entrainer accounts for total extractant is 8%, extracting pressure 20-30MPa, temperature 60 C, CO 2flow 4ml/g crude drug min, extraction time 120min, obtains supercritical extract, for subsequent use;
(4) Flos Lonicerae, Semen Ziziphi Spinosae, Fructus Lycii are mixed, carry out pulverization process after mix homogeneously, grind into powder, cross 200 order fine powders, for subsequent use;
(5) by above-mentioned steps (1), (4) gained mix homogeneously, crossing 200 mesh sieves, is then that 25mg/100g adds volume fraction 80% ethanol according to mass ratio, wet granulation, grain graininess 25 order, by obtained granule in 70 DEG C of dry 12h, for subsequent use; Then in the obtained microwave extraction thing of step (2), step (3) and supercritical extract, add the dextrin of 20-40%, mix homogeneously, then be that 20ml/100g adds volume fraction 95% ethanol according to concentration, make soft material, cross 20 mesh sieves, granulate, grain graininess 25 order, in 80 DEG C of dry 120min, for subsequent use; By above-mentioned two kinds of granule mix homogeneously, add magnesium stearate and carry out tabletting, be prepared into medicinal tablet.
Toxicity test:
Laboratory animal
White mice is provided by Qingdao City's laboratory animal and animal experimental center.
Mice lavage administration acute toxicity testing
By 50 white mice in laboratory conditions adaptability feed after 3d, be divided into 2 groups at random, often organizing 25, is experimental group and matched group.After fasting 8h (can't help water), experimental group gives Chinese medicinal tablet of the present invention (tablet dissolved is obtained suspension in the water) gavage as embodiment 3 prepares, and matched group gives normal saline gavage.Observe the situation such as spirit, behavior, diet wish of white mice after gavage in seven days, record mice dying T/A, cuts open the dead white mice of inspection, observes the pathological change of each organs and tissues.Experimental result shows none death of white mice in seven days, and put to death each internal organs of white mice anatomic observation and do not find toxic reaction, experimental group and matched group white mice are without any difference.
Rat oral gavage administration long term toxicity test
Toxicity test:
Choose SD rat 80, be divided into matched group, experimental group often to organize 40, male and female half and half.Matched group adopts normal saline gavage, and experimental group adopts the present embodiment 1 tablet to be scattered in water, gavage, and dosage is 10g (crude drug) kg -1(being equivalent to 100 times of adult's medication), three times on the one gavages, successive administration 15 weeks, observes the index such as animal ordinary circumstance and body weight.Drug withdrawal is after three days, and observe the index such as hair, behavior, defecation, body weight of SD rat, result shows all to have no significant effect, and internal organs naked eyes do not find difference change.Put to death rat, tissue slice is carried out to its internal organs, shows without any pathological changes and exception under Electronic Speculum.
Clinical trial:
Case selection:
As the melanomatous medicine for the treatment of, select the routine clinical observation of melanoma patients 100 of making a definite diagnosis, with the Chinese medicine composition of the embodiment of the present invention 3, oral, each 2g, every day 3 times, warm water delivery service after meal; It within 7 days, is 1 course for the treatment of.
Efficacy determination:
Cure: melanin pigmentation disappears, skin itch sense disappears, and tumor body disappears, and half a year is without recurrence;
Effective: melanoma body reduces, and melanin pigmentation shoals, skin itch sense alleviates;
Invalid: above-mentioned clinical symptoms is without significant change.
Therapeutic outcome: through the treatment of five courses for the treatment of, in accept for medical treatment 100 routine melanoma patients, cures 86 examples, effective 7 examples, invalid 8 examples, cure rate 86%, total effective rate 93%, determined curative effect, cure rate is high, and patient is over the course for the treatment of without any discomfort, has no side effect.
The above; it is only most preferred embodiment of the present invention; not any pro forma restriction is done to the present invention; any those of ordinary skill in the art; do not departing under technical solution of the present invention ambit; utilize the method content of above-mentioned announcement to make many possible variations and modification to technical solution of the present invention, all belong to the scope of claims protection.

Claims (8)

1. treat a melanomatous Chinese medicine composition, it is characterized in that: be made up of following component:
Herba Taxilli, Fructus Schisandrae Sphenantherae, Herba Hedyotidis Diffusae, Spina Gleditsiae, Radix Angelicae Sinensis, Semen Impatientis, Semen Persicae, Radix Morindae Officinalis, Folium Mori, Fructus Lycii, Flos Lonicerae, the Rhizoma Atractylodis Macrocephalae, Hemerocallis fulva L., Radix Et Rhizoma Rhei, Poria, Chrysosplenium nudicaule Bunge, Herba Ixeritis Denticulatae, Radix Gentianae, Herba Scutellariae Barbatae, Radix Zanthoxyli, Endothelium Corneum Gigeriae Galli, Semen Platycladi, Pericarpium Granati, Rhizoma Curcumae Longae, the Radix Astragali, Rhizoma Gastrodiae, Semen Ziziphi Spinosae, Herba Lycopodii.
2. one according to claim 1 treats melanomatous Chinese medicine composition, it is characterized in that: be made up of each component of following parts by weight:
Herba Taxilli 1-30 part, Fructus Schisandrae Sphenantherae 1-30 part, Herba Hedyotidis Diffusae 1-30 part, Spina Gleditsiae 1-30 part, Radix Angelicae Sinensis 1-30 part, Semen Impatientis 1-30 part, Semen Persicae 1-30 part, Radix Morindae Officinalis 1-30 part, Folium Mori 1-30 part, Fructus Lycii 1-30 part, Flos Lonicerae 1-30 part, Rhizoma Atractylodis Macrocephalae 1-30 part, Hemerocallis fulva L. 1-30 part, Radix Et Rhizoma Rhei 1-30 part, Poria 1-30 part, Chrysosplenium nudicaule Bunge 1-30 part, Herba Ixeritis Denticulatae 1-30 part, Radix Gentianae 1-30 part, Herba Scutellariae Barbatae 1-30 part, Radix Zanthoxyli 1-30 part, Endothelium Corneum Gigeriae Galli 1-30 part, Semen Platycladi 1-30 part, Pericarpium Granati 1-30 part, Rhizoma Curcumae Longae 1-30 part, Radix Astragali 1-30 part, Rhizoma Gastrodiae 1-30 part, Semen Ziziphi Spinosae 1-30 part, Herba Lycopodii 1-30 part.
3. one according to claim 2 treats melanomatous Chinese medicine composition, it is characterized in that: be made up of each component of following parts by weight:
Herba Taxilli 1-15 part, Fructus Schisandrae Sphenantherae 1-15 part, Herba Hedyotidis Diffusae 1-15 part, Spina Gleditsiae 1-15 part, Radix Angelicae Sinensis 1-15 part, Semen Impatientis 1-15 part, Semen Persicae 1-15 part, Radix Morindae Officinalis 1-15 part, Folium Mori 1-15 part, Fructus Lycii 1-15 part, Flos Lonicerae 1-15 part, Rhizoma Atractylodis Macrocephalae 1-15 part, Hemerocallis fulva L. 1-15 part, Radix Et Rhizoma Rhei 1-15 part, Poria 1-15 part, Chrysosplenium nudicaule Bunge 1-15 part, Herba Ixeritis Denticulatae 1-15 part, Radix Gentianae 1-15 part, Herba Scutellariae Barbatae 1-15 part, Radix Zanthoxyli 1-15 part, Endothelium Corneum Gigeriae Galli 1-15 part, Semen Platycladi 1-15 part, Pericarpium Granati 1-15 part, Rhizoma Curcumae Longae 1-15 part, Radix Astragali 1-15 part, Rhizoma Gastrodiae 1-15 part, Semen Ziziphi Spinosae 1-15 part, Herba Lycopodii 1-15 part.
4. the one according to claims 1 to 3 treats melanomatous Chinese medicine composition, it is characterized in that: each component composition also comprising following parts by weight: Cycas revoluta 1-15 part.
5. the one according to Claims 1-4 treats melanomatous Chinese medicine composition, it is characterized in that: each component composition also comprising following parts by weight: Ganoderma 1-15 part, Bufo siccus 1-15 part.
6. one according to claim 1 treats melanomatous Chinese medicine composition, it is characterized in that: the dosage form of described Chinese medicine preparation is: sublimed preparation, powder, injection, plaster, syrup, oral liquid, suck agent, granule, sugar coated tablet, film coated tablet, capsule.
7., according to a kind of preparation method for the treatment of melanomatous Chinese medicine composition described in claim 1 to 6, it is characterized in that: comprising the following steps of preparation:
(1) by Herba Taxilli, Fructus Schisandrae Sphenantherae, Herba Hedyotidis Diffusae, Spina Gleditsiae, Radix Angelicae Sinensis, Semen Impatientis, Semen Persicae, Radix Morindae Officinalis, clean, put into container, add 80% ethanol of 1-10 times amount, at 60-100 DEG C of alcoholization 50-120 minute, add the water of 6 times amount again, 75 DEG C of insulations 100 minutes, concentration and recovery ethanol, obtained mixed liquor, filter mixed liquor obtains filtrate, and the Chinese medicine residue of filtration repeats above extraction step; Merge twice filtrate, with aperture at 1000um, molecular cut off is in the high temperature resistant high rejection rolling NF membrane of 300KDalton, isolate the large particulate matter in filtrate and supernatant, supernatant concentration, at simmer down to 60 DEG C, relative density is the thick paste of 1.10 ~ 1.14 and dry, pulverize powdered, for subsequent use;
(2) by Folium Mori, the Rhizoma Atractylodis Macrocephalae, Hemerocallis fulva L., Radix Et Rhizoma Rhei, Poria, Chrysosplenium nudicaule Bunge, Herba Ixeritis Denticulatae, Radix Gentianae, Radix Zanthoxyli, Endothelium Corneum Gigeriae Galli, clean, put into container, add 1-8 times amount 80% ethanol, drop in microwave extracting apparatus and carry out microwave extracting, extraction power 1000W, extracts 3 times, each 30 minutes, combining extraction liquid, concentrated, be added on DiaionHP-10 macroporous adsorptive resins, 80% ethanol elution, collect 4 times amount column volume eluents, decompression recycling ethanol, concentrated and dry, obtain microwave extraction thing, for subsequent use;
(3) by Semen Platycladi, Pericarpium Granati, Rhizoma Curcumae Longae, the Radix Astragali, Rhizoma Gastrodiae, Herba Lycopodii, Cycas revoluta, Herba Scutellariae Barbatae, Ganoderma, Bufo siccus, CO is joined 2in supercritical extraction device, ethanol is as entrainer, and the percent by volume that entrainer accounts for total extractant is 8%, extracting pressure 20-30MPa, temperature 60 C, CO 2flow 4ml/g crude drug min, extraction time 120min, obtains supercritical extract, for subsequent use;
(4) Flos Lonicerae, Semen Ziziphi Spinosae, Fructus Lycii are mixed, carry out pulverization process after mix homogeneously, grind into powder, cross 200 order fine powders, for subsequent use;
(5) by above-mentioned steps (1), (4) gained mix homogeneously, crossing 200 mesh sieves, is then that 25mg/100g adds volume fraction 80% ethanol according to mass ratio, wet granulation, grain graininess 25 order, by obtained granule in 70 DEG C of dry 12h, for subsequent use; Then in the obtained microwave extraction thing of step (2), step (3) and supercritical extract, add the dextrin of 20-40%, mix homogeneously, then be that 20ml/100g adds volume fraction 95% ethanol according to concentration, make soft material, cross 20 mesh sieves, granulate, grain graininess 25 order, in 80 DEG C of dry 120min, for subsequent use; By above-mentioned two kinds of granule mix homogeneously, add excipient substance, be prepared into corresponding pharmaceutical dosage form.
8. a kind of preparation method for the treatment of melanomatous Chinese medicine composition according to claim 7, is characterized in that: prepared by described tablet comprises the following steps:
(1) by Herba Taxilli, Fructus Schisandrae Sphenantherae, Herba Hedyotidis Diffusae, Spina Gleditsiae, Radix Angelicae Sinensis, Semen Impatientis, Semen Persicae, Radix Morindae Officinalis, clean, put into container, add 80% ethanol of 1-10 times amount, at 60-100 DEG C of alcoholization 50-120 minute, add the water of 6 times amount again, 75 DEG C of insulations 100 minutes, concentration and recovery ethanol, obtained mixed liquor, filter mixed liquor obtains filtrate, and the Chinese medicine residue of filtration repeats above extraction step; Merge twice filtrate, with aperture at 1000um, molecular cut off is in the high temperature resistant high rejection rolling NF membrane of 300KDalton, isolate the large particulate matter in filtrate and supernatant, supernatant concentration, at simmer down to 60 DEG C, relative density is the thick paste of 1.10 ~ 1.14 and dry, pulverize powdered, for subsequent use;
(2) by Folium Mori, the Rhizoma Atractylodis Macrocephalae, Hemerocallis fulva L., Radix Et Rhizoma Rhei, Poria, Chrysosplenium nudicaule Bunge, Herba Ixeritis Denticulatae, Radix Gentianae, Radix Zanthoxyli, Endothelium Corneum Gigeriae Galli, clean, put into container, add 1-8 times amount 80% ethanol, drop in microwave extracting apparatus and carry out microwave extracting, extraction power 1000W, extracts 3 times, each 30 minutes, combining extraction liquid, concentrated, be added on DiaionHP-10 macroporous adsorptive resins, 80% ethanol elution, collect 4 times amount column volume eluents, decompression recycling ethanol, concentrated and dry, obtain microwave extraction thing, for subsequent use;
(3) by Semen Platycladi, Pericarpium Granati, Rhizoma Curcumae Longae, the Radix Astragali, Rhizoma Gastrodiae, Herba Lycopodii, Cycas revoluta, Herba Scutellariae Barbatae, Ganoderma, Bufo siccus, CO is joined 2in supercritical extraction device, ethanol is as entrainer, and the percent by volume that entrainer accounts for total extractant is 8%, extracting pressure 20-30MPa, temperature 60 C, CO 2flow 4ml/g crude drug min, extraction time 120min, obtains supercritical extract, for subsequent use;
(4) Flos Lonicerae, Semen Ziziphi Spinosae, Fructus Lycii are mixed, carry out pulverization process after mix homogeneously, grind into powder, cross 200 order fine powders, for subsequent use;
(5) by above-mentioned steps (1), (4) gained mix homogeneously, crossing 200 mesh sieves, is then that 25mg/100g adds volume fraction 80% ethanol according to mass ratio, wet granulation, grain graininess 25 order, by obtained granule in 70 DEG C of dry 12h, for subsequent use; Then in the obtained microwave extraction thing of step (2), step (3) and supercritical extract, add the dextrin of 20-40%, mix homogeneously, then be that 20ml/100g adds volume fraction 95% ethanol according to concentration, make soft material, cross 20 mesh sieves, granulate, grain graininess 25 order, in 80 DEG C of dry 120min, for subsequent use; By above-mentioned two kinds of granule mix homogeneously, add magnesium stearate and carry out tabletting, be prepared into medicinal tablet.
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CN103536674A (en) * 2013-11-02 2014-01-29 杨献华 Medicament composition capable of preventing melanin tumor
CN104095113A (en) * 2014-06-16 2014-10-15 胡安然 Tea for alleviating melanoma
CN104491766A (en) * 2015-01-27 2015-04-08 邹士东 Traditional Chinese medicine composition used for treating melanin tumor and preparation method of traditional Chinese medicine composition
CN104546964A (en) * 2015-01-29 2015-04-29 牟忠臣 Traditional Chinese medicine quantification standard method

Cited By (2)

* Cited by examiner, † Cited by third party
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CN105497810A (en) * 2016-01-20 2016-04-20 青岛云天生物技术有限公司 Pharmaceutical composition for treating malignant melanoma and application thereof
CN106267119A (en) * 2016-08-08 2017-01-04 青岛友诚高新技术有限公司 The Chinese medicine composition for the treatment of jaundice

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