CN101647901B - Oral Chinese herba preparation for treating postpartum qi and blood deficiency of woman and production method thereof - Google Patents
Oral Chinese herba preparation for treating postpartum qi and blood deficiency of woman and production method thereof Download PDFInfo
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Abstract
本发明涉及一种治疗妇女产后之气血亏虚症的口服中药制剂及其生产方法，包括下列重量份比例组分，黄芪、当归、熟地黄、白术、白芍、川芎、扶芳藤、陈皮、甘草九味中药材经加水煎煮、滤过、浓缩、醇沉、滤过、回收乙醇、浓缩等工序制成清膏，加淀粉、糊精、微晶纤维素、聚乙烯吡咯烷酮等制粒、干燥、整粒并分装成5000粒、包装，即得。本发明配方简单、易加工，成本低廉，本产品具有复方细，有效止血、疗效好，特别适用于术后止血。The invention relates to an oral Chinese medicine preparation for treating postpartum qi and blood deficiency and a production method thereof, comprising the following components in parts by weight, astragalus, angelica, rehmannia glutinosa, Atractylodes macrocephala, peony root, chuanxiong, Fufangteng, tangerine peel, Nine flavors of licorice Chinese medicinal materials are decocted with water, filtered, concentrated, alcohol-precipitated, filtered, ethanol recovered, concentrated and other processes to make a clear paste, and starch, dextrin, microcrystalline cellulose, polyvinylpyrrolidone, etc. are added to granulate, Dried, sized and divided into 5,000 grains, packaged, ready to be obtained. The formula of the invention is simple, easy to process and low in cost. The product has the advantages of fine compound formula, effective hemostasis and good curative effect, and is especially suitable for postoperative hemostasis.
Description
Technical field
The present invention relates to oral Chinese medicine preparation and production method thereof that a kind of women's of treatment postpartum qi and blood loses deficient syndrome.
Background technology
At present, women's's puerperal (artificial abortion and gynecological's postoperative) deficiency of qi and blood disease is one of modal a kind of disease of the women of child-bearing age, by theory of Chinese medical science, this disease main reason is because women's puerperal (artificial abortion and gynecological's postoperative) QI and blood runs off and to have a surplus and biochemical deficiency, plain body weakness, change source deficiency, lose blood or taste prolonged deficiency etc. several times, clinical manifestation is that the light matter of menstruation color is rare, the later stage amount is few, even amenorrhea, pale or sallow complexion are not magnificent, Mental fatigue is unable, the loose stool is thin, light red tongue, white and thin fur, thready pulse without strength.The medicine and the method for this disease of treatment are more at present, and Western medicine is based on iron supplement, zinc and vitamin, but effect often is not fine; Chinese medicine preparation is with its determined curative effect, and is easy to use, and toxic and side effects is little occupies crucial status on clinical treatment.Open source literature had once been reported the content of some Chinese medicine preparation treatment women's puerperal (artificial abortion and gynecological's postoperative) deficiency of qi and blood disease,
The Zhejiang clinical medicine .2002 of deficiency of qi and blood type hypogalactia puerpera's treatment by Chinese herbs and clinical care [author] Yu Yunjuan [mechanism] Zhejiang Province Haining City Hospital of TCM [periodical name], 4 (4)-304[digests] observation deficiency of qi and blood type hypogalactia puerpera 92 examples, using the square medicine of Chinese medicines compositions such as Radix Angelicae Sinensis, the Radix Astragali, Fructus Lycii, the Rhizoma Atractylodis Macrocephalae, Poria, Radix Bupleuri treats, the result shows, clinical cure 73 examples, cure rate is 79.3%, total effective rate reaches 96.7%, curative effect obviously is better than matched group, is worthy to be popularized.
Add the Shaanxi traditional Chinese medical science .1994 of the holy more soup of flavor treatment dizzy 98 examples of deficiency of qi and blood type [author] Shi Huanming [mechanism] Hanzhong area phosphorus ore worker's hospital [periodical name], 15 (9)-390[digests] with the traditional Chinese medical science heart, liver,spleen,kidney four dirty internal injuries are deficient is pathogenesis, adopt the benefiting QI and nourishing blood method, from intending adding dizzy 98 examples of flavor holy more soup (Radix Ginseng, Radix Angelicae Sinensis, the Radix Astragali, Radix Rehmanniae Preparata etc.) treatment deficiency of qi and blood type, all clinical recovery.Prompting this law is one of dizzy effective ways of treatment deficiency of qi and blood type.
Add the Shaanxi traditional Chinese medical science .2008 of flavor BAZHEN TANG treatment deficiency of qi and blood type hypertension 60 examples [author] Wang Qiaofan [mechanism] hospitals of traditional Chinese hospital, Hainan Province [periodical name], 29 (2)-163-164[digests] purpose: observation adds the hypertensive clinical efficacy of flavor BAZHEN TANG (Radix Rehmanniae Preparata, Radix Angelicae Sinensis, the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba, Rhizoma Chuanxiong, Rhizoma Gastrodiae, Radix Codonopsis, Rhizoma Alismatis, Poria, Radix Glycyrrhizae Preparata) treatment deficiency of qi and blood type.Method: 120 routine patients are divided into add flavor BAZHEN TANG treatment group 60 example and YANSUAN FUGUILIQIN JIAONANG matched group 60 examples at random.The result: treatment group total effective rate is 92%, matched group 74%, and treatment group curative effect is better than matched group (P＜0.05).Prompting: add your sticking card of flavor and treat the deficiency of qi and blood type hypertension, satisfactory effect is worth clinical expansion.
The Yunnan Chinese medicine magazine .2001 of lactogenesis soup treatment deficiency of qi and blood hypogalactia 56 examples in puerperal [author] Deng Qinghua [mechanism] Dengjiang County, Yunnan Province institute of traditional Chinese medicine [periodical name], 22 (1)-25[digests] the author is with from intending lactogenesis soup treatment deficiency of qi and blood hypogalactia 56 examples in puerperal, side's medicine is formed: Radix Angelicae Sinensis, the Radix Paeoniae Alba, Rhizoma Chuanxiong, Radix Trichosanthis, Semen Vaccariae, wooden barrel, the Radix Astragali, Squama Manis(parched), Medulla Tetrapanacis, Radix Platycodonis, Fructus Liquidambaris, the result shows, total effective rate is 92.8%, curative effect is comparatively satisfied, is worthy to be popularized.
The Chinese Medicine journal .2002 of the 473rd hospital of the pharmacology of WUJI BAIFENG WAN and clinical progress [author] Wang Lihua [mechanism] PLA [periodical name], 17 (supplementary issue)-308-310[digests] WUJI BAIFENG WAN be according to bright. " BAIFENGWAN " side of Gong Tingxian " Longevity and Life Preservation " volume seven adds and subtracts and forms.Contain the Chinese medicine of benefiting qi and nourishing bloods such as Gallus Domesticus, Radix Rehmanniae Preparata, Radix Ginseng, Radix Angelicae Sinensis, Rhizoma Chuanxiong, adjusting meridian and stopping leukorrhea in the side mostly, be used for many department of obstetrics and gynecology diseases that deficiency of both QI and blood causes, clinical efficacy is definite, is described as gynecological's good medicine.Total effective rate as its treatment prolonged lochia and postoperative hemorrhage (artificial abortion, last ring and ring postoperative hemorrhage) is 75%.
The Chinese medicine preparation of above-mentioned open source literature report all has certain therapeutical effect to treatment women's puerperal (artificial abortion and gynecological's postoperative) deficiency of qi and blood disease respectively, and some therapeutic effect is also fairly good.Yet, exist efficient functional single in the above-mentioned bibliographical information, can only take stopgap measures and can not effect a permanent cure, the prescription that has is too complicated, dosage is big.
Summary of the invention
The objective of the invention is to overcome the weak point that exists in the above-mentioned technology, provide that a kind of prescription is simple, drug dose is less relatively, cost is low, effectively hemostatic treatment women postpartum qi and blood loses the oral Chinese medicine preparation and the production method thereof of deficient syndrome.
In order to achieve the above object, the technical solution used in the present invention is:
Comprise following weight portion ratio component
Radix Astragali 12-30 part, Radix Angelicae Sinensis 6-18 part, Radix Rehmanniae Preparata 6-18 part, Rhizoma Atractylodis Macrocephalae 6-12 part, Radix Paeoniae Alba 6-12 part, Rhizoma Chuanxiong 3-9 part, Caulis Seu Folium Euonymi Fortunei 6-18 part, Pericarpium Citri Reticulatae 1.2-6 part, Radix Glycyrrhizae 1.2-6 part.
The preparation method of granule is got the Radix Astragali; Radix Angelicae Sinensis; Radix Rehmanniae Preparata; the Rhizoma Atractylodis Macrocephalae; the Radix Paeoniae Alba; Rhizoma Chuanxiong; Caulis Seu Folium Euonymi Fortunei; Pericarpium Citri Reticulatae; Radix Glycyrrhizae nine flavor Chinese crude drugs are put in the multi-function extractor; decoct with water secondary; add for the first time 10 times of amounts; flood after 1 hour; decocted 2 hours; add for the second time 6 times of water gagings; decocted 2 hours; collecting decoction; filter with gauze or 50 order nylon leaching nets; filtrate moves to carries out normal pressure or concentrating under reduced pressure in the enrichment facility; to gained clear paste relative density be 1.10-1.15; measuring temperature is 65 ℃; put in the settling tank; adding ethanol makes and contains alcohol amount and reach 65%; left standstill 24 hours; with filtrations such as 50 order nylon leaching nets or filter press; filtrate moves in the multi-functional concentrated filling, and reclaiming ethanol and being concentrated into relative density is 1.35-1.40, and the measurement temperature is 80 ℃ a clear paste; add 4.5 times of sucrose; ethanol or 3 times of dextrin; microcrystalline Cellulose; polyvinylpyrrolidone is an amount of; steviol glycosides etc.; put and made sugar or sugar type granules in the granulator, 80-100 ℃ of drying, the rearmounted total machine mixing that mixes of pelletizing machine arrangement; packing, promptly.
Advantage of the present invention is:
Simple, the easily processing of prescription, with low cost, it is thin that this product has a compound recipe, and effectively hemostasis, good effect are specially adapted to the postoperative hemostasis.
The specific embodiment
Below embodiments of the invention are described in further detail.
Chinese medicine preparation of the present invention is to make with the raw material of Chinese medicine of following weight fraction:
Radix Astragali 2-5, Radix Angelicae Sinensis 1-3, Radix Rehmanniae Preparata 1-3, Rhizoma Atractylodis Macrocephalae 1-2, Radix Paeoniae Alba 1-2, Rhizoma Chuanxiong 0.5-1.5, Caulis Seu Folium Euonymi Fortunei 1-3, Pericarpium Citri Reticulatae 0.2-1, Radix Glycyrrhizae 0.2-1.
With making granule (sugar and Sugarless type are arranged), tablet, the pharmaceutically common oral formulations of capsule respectively behind the above-mentioned raw material of Chinese medicine adding adjuvant.These formulation products have the merit of vigorate qi and replenish the blood, are used for women's deficiency of qi and blood disease of puerperal (containing artificial abortion and gynecological's postoperative) clinically, and disease is seen dizziness and blurred vision, spiritlessness and weakness, pale complexion, palpitation and insomnia etc.
Below be described in detail granule (sugar and Sugarless type are arranged), tablet, capsular preparation method respectively:
1, the preparation of granule (sugar and Sugarless type are arranged):
The Radix Astragali, Radix Angelicae Sinensis, Radix Rehmanniae Preparata, the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba, Rhizoma Chuanxiong, Caulis Seu Folium Euonymi Fortunei, Pericarpium Citri Reticulatae, the Radix Glycyrrhizae nine flavor Chinese crude drugs of getting above prescription through decoct with water, filter, concentrate, precipitate with ethanol, filtration, recovery ethanol, enrichment process make clear paste, with sucrose, ethanol or dextrin, microcrystalline Cellulose, an amount of, the steviol glycosides of polyvinylpyrrolidone, sugar or sugar type granules have been made, dry, packing, promptly.
2, the preparation of tablet:
The Radix Astragali, Radix Angelicae Sinensis, Radix Rehmanniae Preparata, the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba, Rhizoma Chuanxiong, Caulis Seu Folium Euonymi Fortunei, Pericarpium Citri Reticulatae, the Radix Glycyrrhizae nine flavor Chinese crude drugs of getting above prescription through decoct with water, filter, concentrate, precipitate with ethanol, filtration, recovery ethanol, enrichment process make clear paste, add starch, dextrin mixing, drying, pulverizing, medicated powder adds microcrystalline Cellulose, polyvinylpyrrolidone granulation, dry, granulate, add magnesium stearate, Pulvis Talci mixing at last, tabletting, packing, promptly.
3, the preparation of capsule:
The Radix Astragali, Radix Angelicae Sinensis, Radix Rehmanniae Preparata, the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba, Rhizoma Chuanxiong, Caulis Seu Folium Euonymi Fortunei, Pericarpium Citri Reticulatae, the Radix Glycyrrhizae nine flavor Chinese crude drugs of getting above prescription through decoct with water, filter, concentrate, precipitate with ethanol, filtration, recovery ethanol, enrichment process make clear paste, add starch, dextrin, microcrystalline Cellulose, polyvinylpyrrolidone granulation, drying, granulate and packing, packing, promptly.
The granule that the present invention makes with raw material of Chinese medicine is a kind of water-soluble granular formulation, and this medicine is put in the water and can be dissolved rapidly; Tablet is owing to there is a disintegrating agent, can be in the oral cavity or the rapid disintegrate of the intestines and stomach, absorption and distribution; Capsule can disintegrate rapidly, absorption and distribution in the intestines and stomach owing to disintegrating agent is arranged.These medicaments dissolve, can be absorbed rapidly and distribute after the disintegrate, and this medical instrument has the merit of stronger vigorate qi and replenish the blood, and the patient uses back about 7 days effectively disease controlling, 2-4 the course of treatment big multipotency reach the healing purpose.
Below be the effect of each raw material of Chinese medicine preparation of the present invention and the mechanism of curing the disease:
The Radix Astragali: be the dry root of the leguminous plant Radix Astragali or astragalus mongholicus Bge.Nature and flavor are sweet, tepor; Go into the lung spleen channel; Give birth to and use: benefit is defended consolidating superficial resistance, inducing diuresis to remove edema, poison holding, granulation promoting; Control spontaneous perspiration, night sweat, arthralgia due to stagnation of blood, edema, carbuncle are not burst or are burst and do not hold back for a long time.Process usefulness: invigorating the spleen and replenishing QI; Control the internal injury overstrain, diarrhea due to hypofunction of the spleen, proctoptosis, deficiency of vital energy blood prostration, metrorrhagia and leukorrhagia, and the card of all weakness of QI blood deficiency." Japan hanako materia medica " claims: " Radix Astragali helps the gas strengthening bone and muscle, and the ， Po Disorder addiction of enriching blood of putting on flesh is controlled scrofula, and wart is superfluous, hemorrhoidal hamorrhage, and metrorrhagia, leukorrhagia, dysentery with red and white feces, all diseases of antenatal back, month time is irregular, quenches one's thirst phlegmatic cough; And control wind syndrome of head, pyretic toxicity, Akamu etc." modern pharmacology studies show that, Radix Astragali diuresis, reduces effects such as physiological urinary protein excretion, strong, blood pressure lowering.In motherland's medical science it is considered as " key medicine of QI invigorating ".
Radix Angelicae Sinensis: be the root of umbelliferae angelica.Main component is a volatile oil.The sweet suffering of nature and flavor, temperature; Go into the heart, liver, spleen channel; Have benefiting blood and regulating blood circulation, menstruction regulating and pain relieving, the effect of moisturizing laxation is regarded as " key medicine of menstruction regulating and pain relieving ", and clinically in order to the treatment menoxenia, amenorrhea stomachache ， mass in the abdomen knot is poly-, metrorrhagia; Headache due to deficiency of blood, dizzy, flaccidity syndrome and arthralgia syndrome; The dryness of the intestine dyschezia is heavy after the bloody dysentery; Ulcer sores, injury from falling down." Japan hanako materia medica " claims: " control a wind cutting, all blood are mended all labor, and broken stagnant blood is supported fresh blood and main Disorder addiction." effect such as modern pharmacology studies show that, Radix Angelicae Sinensis has g palace, the seat of being contracted in, improves metabolism, enriches blood, suppresses heart, antibiotic.Clinical research shows, is 87% to work as the total effective rate that is classified as main preparation for treating menopathy; The total effective rate of treatment rhinitis is 98.3%.
Radix Rehmanniae Preparata: being called for short Radix Rehmanniae Preparata, is scrophulariaceae rehmannia glutinosa plant or bosom celebrating Radix Rehmanniae rhizome, shines through the processing steaming to form.Nature and flavor are sweet, tepor; Go into liver, kidney channel; Has YIN nourishing, the effect of enriching blood; In order to treatment deficiency of YIN insufficiency of blood, the waist knee flaccidity, the chronic cough hectic fever due to YIN-deficiency, seminal emission, metrorrhagia, menoxenia is quenched one's thirst, frequency of micturition, deafness, blurred vision." medicine justice " record: " Radix Rehmanniae Preparata, nationality wine cooks, and bitter in the mouthization is sweet, and alternating temperature cool in nature is specially gone into Liver Channel and is enriched blood.Bitter anxious because of liver, delay it with sweet, the main warm gallbladder of holding concurrently can beneficial painstaking effort, more the kidney invigorating water.All internal injury deficiencies, bitter will is a tax on one's mind, the suffering blood trouble, the consumption of indulging in sensual pleasures is smart, and the regulating menstruation tire produces, and all should use this.Settling five organs, and blood vessels, the profit skin, nourishing the heart to keep a sound mind, peaceful soul, nourish Kidney-Yin, packing bone marrow, for panacea also ".
The Rhizoma Atractylodis Macrocephalae: be feverfew Rhizoma Atractylodis Macrocephalae rhizome.Contain volatile oil 1.4%, main component is atractylol, atractylone etc., and contains vitamin A.The property bitter but sweet flavor, temperature; Go into spleen, stomach warp; The tool spleen reinforcing, stomach reinforcing, dampness and in effect, clinically in order to the treatment deficient QI of the spleen and stomach, anorexia, the asthenia weak breath, deficiency-distension is had loose bowels, phlegm retention, edema, jaundice, arthralgia chiefly caused by damp pathogen, dysuria, dizziness, spontaneous perspiration, cards such as nausea uneasiness." book on Chinese herbal medicine is looked for the truth " record: " why specially the Rhizoma Atractylodis Macrocephalae enriching spleen-QI? lid is bitter wet with spleen, anxious food bitter flavor having drying effect, the spleen desire is slow, anxious food sweet flavor has the effect of relaxing; Rhizoma Atractylodis Macrocephalae bitter in the mouth and sweet can the dampness tonifying the spleen, and the slow spleen of reactivation promotes the production of body fluid.And its property is the warmest, and clothes then can be with strong food rapid digestion of food, for spleen QI invigorating first key medicine also." modern pharmacology studies show that, the Rhizoma Atractylodis Macrocephalae has diuresis, blood sugar lowering, anticoagulant, effect such as strong, antibiotic.
The Radix Paeoniae Alba: the original name Radix Paeoniae Alba is the root of ranunculaceae plant Radix Paeoniae (cultigen).Root contains paeoniflorin, paeonol, paeoniflorin, and benzoic acid is about 1.07%, volatile oil, fatty oil, resin, tannin, sugar, starch, phlegmatic temperament, protein, cupreol and triterpenes.The nature and flavor picric acid, cold; Go into liver, spleen channel; Have nourishing blood to suppress the hyperactive liver, slow middle pain relieving, yin fluid astringing is received the effect of antiperspirant.Clinically in order to the treatment breast abdomen pain over the hypochondriac region, dysentery stomachache, spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, cards such as leukorrhagia." Japan hanako materia medica " record: " control wind and mend consumptive disease, all diseases of main woman, and all diseases in antenatal back, Tong Yueshui, the relieving restlessness of bringing down a fever, QI invigorating is controlled a day capable hot disease, pestilence miasma mania and irritation, married woman's blood fortune reaches hemorrhoidal hamorrhage and rushes down blood, the hemorrhoid complicated by anal fistula carbuncle on the back, the skin ulcer scabies, headache makes eye bright conjunctival congestion, bulbar conjunctiva polyp." modern pharmacology studies show that the Radix Paeoniae Alba has the antibiotic effect of Denging.
Rhizoma Chuanxiong: be the dry rhizome of samphire Rhizoma Chuanxiong Ligusticum chuanxiong Hort..Rhizome contains volatile oil, alkaloid, phenolic constituent, lactone, ferulic acid etc.The nature and flavor suffering, temperature; Go into liver, gallbladder meridian; Have activating QI to alleviate the depression, dispeiling pathogenic wind and removing dampness, the effect of promoting blood circulation and stopping pain is revolved dizzyly in order to treat air-cooled headache clinically, and the hypochondriac pain abdomen is painful, arthralgia due to cold clonic spasm of the muscle, amenorrhea, difficult labour, postpartum stagnation piece pain, cards such as ulcer sores.Chinese medical theory is thought Rhizoma Chuanxiong, and " Xin Xiang walks to scurry and circulation of qi promoting, and blood circulation promoting and blood stasis dispelling is with hemostasis, and the up head and dispeling the wind is lowered to the sea of blood with regulating menstruation.And outer thorough fur, the bypass extremity are the gas medicine in the blood ".So be usually used in taking orally, cure mainly that headache is dizzy, diseases such as rheumatic arthralgia, costa sternales twinge, treating swelling and pain by traumatic injury, amenorrhea dysmenorrhea, menoxenia, arthralgia due to cold spasm, ulcer sores and postpartum stagnation stomachache." Japan hanako materia medica " record: " control a wind cutting, all gas, all strains, all blood are mended five kinds of over strain, and strengthening bone and muscle is transferred many arteries and veins, and broken crux stagnated blood is supported fresh blood, puts on flesh, and serious epistaxis is spitted blood and hematuria, hemorrhoid complicated by anal fistula, brain carbuncle carbuncle on the back, the scrofula wart is superfluous, skin ulcer scabies, and evacuation of pus repercussive blood." the modern medicine scientific research finds that the Rhizoma Chuanxiong extracting solution has certain effect to suppressing the leukaemia; Pharmaceutical research confirms that the Rhizoma Chuanxiong preparation has certain antibacterial action, especially Bacillus typhi, Salmonella paratyphi, vibrio cholera, bacillus pyocyaneus and pathogenic dermatophytes etc. is all had inhibitory action.The ligustrazine that is contained in the Rhizoma Chuanxiong, ferulic acid are received has blood circulation invigorating efficacies, and expansible coronary artery is promoted coronary flow, allevating angina pectoris, and have anti-thrombosis function; Contained cnidium lactone has smooth muscle spasmolysis and suppresses effects such as myenteron, uterine contraction in the Rhizoma Chuanxiong; The Rhizoma Chuanxiong preparation also has anti-lonizing radiation effect.
Caulis Seu Folium Euonymi Fortunei: head is stated from supplement to the Herbal, has another name called: the winged euonymus of creeping is the stem and leaf of Celastraceae plant Caulis Seu Folium Euonymi Fortunei.Contain dulcitol; Seed contains prolycopene and preceding-gamma carotene.Nature and flavor: 1. supplement to the Herbal: bitter in the mouth, little temperature, nontoxic; 2. " Guizhou folk medicine ": property is flat, acrid in the mouth.Have relaxing muscles and tendons and activating QI and blood in the collateral, the effect of hemostasis repercussive is in order to treatment lumbar muscle strain, rheumatic arthralgia, spitting of blood, metrorrhagia, menoxenia, injury and bone fracture, cards such as wound hemorrhage.Supplement to the Herbal record: " all are cold for main all blood, all gas, big main air blood ".
Pericarpium Citri Reticulatae: [another name] red Fructus Citri tangerinae, Radix Campylotropis Hirtella (Herba Myrsines Africanae), river Fructus Citri tangerinae.Peel for rutaceae orange Citrusreticulata Bianco.Contain Nobiletin, Hesperidin, neohesperidin, hesperetin, oxedrine, chromocor compound etc. in the Pericarpium Citri Reticulatae.Pericarpium Citri Reticulatae volatile oil content is 1.5～2.0%, and the Pericarpium citri reticuatae chachiensis volatile oil content is 1.2～3.2%, and its composition has α-thujene, limonene etc.Warm in nature, bitter in the mouth, suffering.Return lung, spleen channel.Has regulating qi-flowing for strengthening spleen, the effect of drying dampness to eliminate phlegm.Be used for the treatment of fullness in the epigastrium and chest, lack of appetite and vomiting, cough ant phlegm.Compendium of Material Medica record: " the treatment sound of vomiting regurgitation of vomitting is noisy, the time vomiting watery fluid, fullness and oppression sensation in the epigastrium due to accumulation of phlegm is coughed malaria, stool is inaccessible, married woman's acute mastitis.Go into foodstuff, separate fish raw meat poison "." it controls all kinds of diseases and ailments, always gets the merit of its dampness of regulating the flow of vital energy.Then mend with tonic, then rush down, then rise, then fall with falling medicine with Hydrargyri Oxydum Rubrum with cathartic." pharmacological research shows: this product decoct is to rabbit and white mice intestine in vitro; anesthetized rabbit, dog stomach and bowel movement all have direct repression; decoct can strengthen cardiac contractile force in a small amount; cardiac output is increased, and coronary dilation increases coronary flow; can suppress heart when heavy dose of; Pericarpium Citri Reticulatae water solublity total alkaloids has the effect of rising blood pressure, and Pericarpium Citri Reticulatae extract has the oxygen-derived free radicals of removing and lipoid peroxidization resistant, and bright Pericarpium Citri tangerinae decoct has the effect of expansion trachea; Volatile oil has the zest phlegm-dispelling functions, main effective ingredient is a limonene, the Pericarpium Citri Reticulatae decoct has inhibitory action to the mice isolated uterine, high concentration then makes it to be complete relaxed state, use the decoct intravenous injection, anesthetized rabbit uterus on the throne is then made it to be the contraction of tetanic property, function of gallbladder promoting is arranged, reduce the serum cholesterol effect.
Radix Glycyrrhizae: this product is the dry root of glycyrrhizic legume Glycyrrhiza uralensis Fisch., Glycyrrhiza inflata Bat. Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L. Glycyrrhiza glabra L..The Radix Glycyrrhizae root and rhizome contains glycyrrhizin, is potassium, the calcium salt of glycyrrhizic acid (glycyrrhizicacid).Still contain liquiritin (liquiritin), liquiritigenin (liquiritigenin), isoliquiritin (isoliquiritin), isoliquiritin unit (isoliquiritigenin), neoliquriitin (neoliquiritin), neoisoliquiritin (neoisoiiquiritin) etc.Nature and flavor are sweet, and are flat, return spleen, stomach, the heart, lung meridian.Has invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, the effect of coordinating the actions of various ingredients in a prescription.Be used for weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, cushion toxicity." property of medicine opinion " record: " cold type of pain in the main abdomen is controlled infantile convulsion, removes distention and fullness in the abdomen; The tonification the five internal organs; Make all poison of drug; Support the kidney qi internal injury, make us cloudy (no) flaccidity; Housewife's human blood drop lumbago; Void and frequent fever; Add and use it." modern pharmacology studies show that, effect such as Radix Glycyrrhizae has antiulcer, gastric acid inhibitory secretion, spasmolytic, protects the liver, arrhythmia, blood fat reducing and anti-atherogenic stalkization, eliminating phlegm and relieving cough, antiinflammatory, calmness, analgesic, analgesia, adrenocortical hormone sample, glucocorticoid sample, diuresis, antiallergic, antiviral, antibiotic, antitumor.
Embodiment 1,
Radix Astragali 2000g, Radix Angelicae Sinensis 1000g, Radix Rehmanniae Preparata 1000g, Rhizoma Atractylodis Macrocephalae 1000g, Radix Paeoniae Alba 1000g, Rhizoma Chuanxiong 500g, Caulis Seu Folium Euonymi Fortunei 1000g, Pericarpium Citri Reticulatae 200g, Radix Glycyrrhizae 200g, adjuvant: sugared type is arranged: about 4.5 parts of sucrose, ethanol are an amount of, and Sugarless type: each is an amount of for about 2.5 parts of dextrin, microcrystalline Cellulose, polyvinylpyrrolidone and steviol glycosides.
Preparation method: the Radix Astragali, Radix Angelicae Sinensis, Radix Rehmanniae Preparata, the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba, Rhizoma Chuanxiong, Caulis Seu Folium Euonymi Fortunei, Pericarpium Citri Reticulatae, the Radix Glycyrrhizae nine flavor Chinese crude drugs of getting above prescription through decoct with water, filter, concentrate, precipitate with ethanol, filtration, recovery ethanol, enrichment process make clear paste, with sucrose, ethanol or dextrin, microcrystalline Cellulose, an amount of, the steviol glycosides of polyvinylpyrrolidone, sugar or sugar type granules have been made, dry, be distributed into 1000 bags, promptly.
The clinical total effective rate of granule that makes with method of the present invention is 92.2%.
Embodiment 2,
Radix Astragali 3000g, Radix Angelicae Sinensis 1670g, Radix Rehmanniae Preparata 1670g, Rhizoma Atractylodis Macrocephalae 1500g, Radix Paeoniae Alba 1500g, Rhizoma Chuanxiong 1000g, Caulis Seu Folium Euonymi Fortunei 1670g, Pericarpium Citri Reticulatae 500g, Radix Glycyrrhizae 500g, adjuvant: sugared type is arranged: about 4.5 parts of sucrose, ethanol are an amount of, and Sugarless type: each is an amount of for about 2.5 parts of dextrin, microcrystalline Cellulose, polyvinylpyrrolidone and steviol glycosides.
Preparation method: the Radix Astragali, Radix Angelicae Sinensis, Radix Rehmanniae Preparata, the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba, Rhizoma Chuanxiong, Caulis Seu Folium Euonymi Fortunei, Pericarpium Citri Reticulatae, the Radix Glycyrrhizae nine flavor Chinese crude drugs of getting above prescription through decoct with water, filter, concentrate, precipitate with ethanol, filtration, recovery ethanol, enrichment process make clear paste, with sucrose, ethanol or dextrin, microcrystalline Cellulose, an amount of, the steviol glycosides of polyvinylpyrrolidone, sugar or sugar type granules have been made, dry, be distributed into 1000 bags, promptly.
The clinical total effective rate of granule that makes with method of the present invention is 92.0%.
Embodiment 3,
Radix Astragali 5000g, Radix Angelicae Sinensis 3000g, Radix Rehmanniae Preparata 3000g, Rhizoma Atractylodis Macrocephalae 2000g, Radix Paeoniae Alba 2000g, Rhizoma Chuanxiong 1500g, Caulis Seu Folium Euonymi Fortunei 3000g, Pericarpium Citri Reticulatae 1000g, Radix Glycyrrhizae 1000g, adjuvant: sugared type is arranged: about 4.5 parts of sucrose, ethanol are an amount of, and Sugarless type: each is an amount of for about 2.5 parts of dextrin, microcrystalline Cellulose, polyvinylpyrrolidone and steviol glycosides.
Preparation method: the Radix Astragali, Radix Angelicae Sinensis, Radix Rehmanniae Preparata, the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba, Rhizoma Chuanxiong, Caulis Seu Folium Euonymi Fortunei, Pericarpium Citri Reticulatae, the Radix Glycyrrhizae nine flavor Chinese crude drugs of getting above prescription through decoct with water, filter, concentrate, precipitate with ethanol, filtration, recovery ethanol, enrichment process make clear paste, with sucrose, ethanol or dextrin, microcrystalline Cellulose, an amount of, the steviol glycosides of polyvinylpyrrolidone, sugar or sugar type granules have been made, dry, be distributed into 1000 bags, promptly.
The clinical total effective rate of granule that makes with method of the present invention is 92.4%.
Embodiment 4,
Radix Astragali 2000g, Radix Angelicae Sinensis 1000g, Radix Rehmanniae Preparata 1000g, Rhizoma Atractylodis Macrocephalae 1000g, Radix Paeoniae Alba 1000g, Rhizoma Chuanxiong 500g, Caulis Seu Folium Euonymi Fortunei 1000g, Pericarpium Citri Reticulatae 200g, Radix Glycyrrhizae 200g, adjuvant: the about 500g of starch, dextrin 250g, microcrystalline Cellulose 50g, polyvinylpyrrolidone 50g, magnesium stearate 30g, Pulvis Talci 30g.
Preparation method: the Radix Astragali, Radix Angelicae Sinensis, Radix Rehmanniae Preparata, the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba, Rhizoma Chuanxiong, Caulis Seu Folium Euonymi Fortunei, Pericarpium Citri Reticulatae, the Radix Glycyrrhizae nine flavor Chinese crude drugs of getting above prescription through decoct with water, filter, concentrate, precipitate with ethanol, filtration, recovery ethanol, enrichment process make clear paste, add starch, dextrin mixing, drying, pulverizing, medicated powder adds granulations such as microcrystalline Cellulose, polyvinylpyrrolidone, dry, granulate, add magnesium stearate, Pulvis Talci mixing at last, be pressed into 5000, packing, promptly.
The clinical total effective rate of granule that makes with method of the present invention is 91.0%.
Embodiment 5,
Radix Astragali 3000g, Radix Angelicae Sinensis 1670g, Radix Rehmanniae Preparata 1670g, Rhizoma Atractylodis Macrocephalae 1500g, Radix Paeoniae Alba 1500g, Rhizoma Chuanxiong 1000g, Caulis Seu Folium Euonymi Fortunei 1670g, Pericarpium Citri Reticulatae 500g, Radix Glycyrrhizae 500g, adjuvant: the about 500g of starch, dextrin 250g, microcrystalline Cellulose 50g, polyvinylpyrrolidone 50g, magnesium stearate 30g, Pulvis Talci 30g.
Preparation method: the Radix Astragali, Radix Angelicae Sinensis, Radix Rehmanniae Preparata, the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba, Rhizoma Chuanxiong, Caulis Seu Folium Euonymi Fortunei, Pericarpium Citri Reticulatae, the Radix Glycyrrhizae nine flavor Chinese crude drugs of getting above prescription through decoct with water, filter, concentrate, precipitate with ethanol, filtration, recovery ethanol, enrichment process make clear paste, add starch, dextrin mixing, drying, pulverizing, medicated powder adds microcrystalline Cellulose, polyvinylpyrrolidone granulation, dry, granulate, add mixings such as magnesium stearate, Pulvis Talci at last, be pressed into 5000, packing, promptly.
The clinical total effective rate of granule that makes with method of the present invention is 92.0%.
Embodiment 6,
Radix Astragali 5000g, Radix Angelicae Sinensis 3000g, Radix Rehmanniae Preparata 3000g, Rhizoma Atractylodis Macrocephalae 2000g, Radix Paeoniae Alba 2000g, Rhizoma Chuanxiong 1500g, Caulis Seu Folium Euonymi Fortunei 3000g, Pericarpium Citri Reticulatae 1000g, Radix Glycyrrhizae 1000g, adjuvant: adjuvant: the about 500g of starch, dextrin 250g, microcrystalline Cellulose 50g, polyvinylpyrrolidone 50g, magnesium stearate 30g, Pulvis Talci 30g.
Preparation method: the Radix Astragali, Radix Angelicae Sinensis, Radix Rehmanniae Preparata, the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba, Rhizoma Chuanxiong, Caulis Seu Folium Euonymi Fortunei, Pericarpium Citri Reticulatae, the Radix Glycyrrhizae nine flavor Chinese crude drugs of getting above prescription through decoct with water, filter, concentrate, precipitate with ethanol, filtration, recovery ethanol, enrichment process make clear paste, add starch, dextrin mixing, drying, pulverizing, medicated powder adds microcrystalline Cellulose, polyvinylpyrrolidone granulation, dry, granulate, add mixings such as magnesium stearate, Pulvis Talci at last, be pressed into 5000, packing, promptly.
The clinical total effective rate of granule that makes with method of the present invention is 93.0%.
Embodiment 7,
Radix Astragali 2000g, Radix Angelicae Sinensis 1000g, Radix Rehmanniae Preparata 1000g, Rhizoma Atractylodis Macrocephalae 1000g, Radix Paeoniae Alba 1000g, Rhizoma Chuanxiong 500g, Caulis Seu Folium Euonymi Fortunei 1000g, Pericarpium Citri Reticulatae 200g, Radix Glycyrrhizae 200g, adjuvant: the about 300g of starch, dextrin 100g, microcrystalline Cellulose 50g, polyvinylpyrrolidone 50g.
The Radix Astragali, Radix Angelicae Sinensis, Radix Rehmanniae Preparata, the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba, Rhizoma Chuanxiong, Caulis Seu Folium Euonymi Fortunei, Pericarpium Citri Reticulatae, the Radix Glycyrrhizae nine flavor Chinese crude drugs of getting above prescription through decoct with water, filter, concentrate, precipitate with ethanol, filtration, recovery ethanol, enrichment process make clear paste, add starch, dextrin, microcrystalline Cellulose, polyvinylpyrrolidone granulation, drying, granulate and be distributed into 5000, packing, promptly.
The clinical total effective rate of granule that makes with method of the present invention is 91.1%.
Embodiment 8,
Radix Astragali 3000g, Radix Angelicae Sinensis 1670g, Radix Rehmanniae Preparata 1670g, Rhizoma Atractylodis Macrocephalae 1500g, Radix Paeoniae Alba 1500g, Rhizoma Chuanxiong 1000g, Caulis Seu Folium Euonymi Fortunei 1670g, Pericarpium Citri Reticulatae 500g, Radix Glycyrrhizae 500g, adjuvant: the about 300g of starch, dextrin 100g, microcrystalline Cellulose 50g, polyvinylpyrrolidone 50g.
The Radix Astragali, Radix Angelicae Sinensis, Radix Rehmanniae Preparata, the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba, Rhizoma Chuanxiong, Caulis Seu Folium Euonymi Fortunei, Pericarpium Citri Reticulatae, the Radix Glycyrrhizae nine flavor Chinese crude drugs of getting above prescription through decoct with water, filter, concentrate, precipitate with ethanol, filtration, recovery ethanol, enrichment process make clear paste, add starch, dextrin, microcrystalline Cellulose, polyvinylpyrrolidone granulation, drying, granulate and be distributed into 5000, packing, promptly.
The clinical total effective rate of granule that makes with method of the present invention is 92.1%.
Embodiment 9,
Radix Astragali 5000g, Radix Angelicae Sinensis 3000g, Radix Rehmanniae Preparata 3000g, Rhizoma Atractylodis Macrocephalae 2000g, Radix Paeoniae Alba 2000g, Rhizoma Chuanxiong 1500g, Caulis Seu Folium Euonymi Fortunei 3000g, Pericarpium Citri Reticulatae 1000g, Radix Glycyrrhizae 1000g, adjuvant: the about 300g of starch, dextrin 100g, microcrystalline Cellulose 50g, polyvinylpyrrolidone 50g.
The Radix Astragali, Radix Angelicae Sinensis, Radix Rehmanniae Preparata, the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba, Rhizoma Chuanxiong, Caulis Seu Folium Euonymi Fortunei, Pericarpium Citri Reticulatae, the Radix Glycyrrhizae nine flavor Chinese crude drugs of getting above prescription through decoct with water, filter, concentrate, precipitate with ethanol, filtration, recovery ethanol, enrichment process make clear paste, add starch, dextrin, microcrystalline Cellulose, polyvinylpyrrolidone granulation, drying, granulate and be distributed into 5000, packing, promptly.
The clinical total effective rate of granule that makes with method of the present invention is 92.9%.
Pharmacology, pharmacodynamics and clinical trial
The results of pharmacodynamic test of this product is as follows:
1, blood tonification effect: stilbene virtue QI and blood granule dosage group has blood tonification effect to losing blood property " blood deficiency " mice.
Prompting: this product has good blood tonification effect, can be able to fast quick-recovery to erythrocyte, the hemoglobin number that puerperal, artificial abortion, various gynecological postoperative reduce.
2, qi invigorating functions: this product can significantly improve the swimming time of " deficiency of vital energy " model mice.
Prompting: this product has good qi invigorating functions, can be to puerperal, artificial abortion, that various gynecological postoperative causes the body weak state to be able to fast quick-recovery is normal.
3, anxiety and sedation: the length of one's sleep of this product energy significant prolongation mice pentobarbital sodium.
Prompting: this product has anxiety and sedation, can eliminate puerperal, artificial abortion, various gynecological anxiety that postoperative causes, wakefulness state.
4, resisting oxygen lack: this product can prolong the mice normal pressure anoxia enduring death time.
Prompting: this product can be eliminated the various anaerobic conditions that caused in puerperal, artificial abortion, various gynecological postoperative.
5, improve immunization: this product can obviously strengthen the phagocytic activity of reticuloendothelial system.
Prompting: this product can improve puerperal, artificial abortion, the various postoperative women's of gynecological immunity.
The clinical test results of this product is as follows:
Curative effect judging standard:
1, produce effects: primary symptom is clearly better or disappears, and the witness integration reduces more than 61%.
2, effective: primary symptom takes a turn for the better, and the witness integration reduces more than the 31-60%.
3, invalid: as not reach above standard person.
This research is carried out clinical observation on the therapeutic effect to the patient that 600 examples suffer from women's's puerperal (containing artificial abortion and gynecological's postoperative) deficiency of qi and blood disease altogether, wherein 500 examples are organized in treatment, matched group 100 examples, treatment group total effective rate is 92.0%, the matched group total effective rate is 85.0%.Two groups relatively, and difference has the significance meaning.
Claims (3)
1. treat the oral Chinese medicine that women's postpartum qi and blood loses deficient syndrome for one kind, it is characterized in that: its crude drug is made up of the component of following weight portion
Radix Astragali 12-30 part, Radix Angelicae Sinensis 6-18 part, Radix Rehmanniae Preparata 6-18 part, Rhizoma Atractylodis Macrocephalae 6-12 part, Radix Paeoniae Alba 6-12 part, Rhizoma Chuanxiong 3-9 part, Caulis Seu Folium Euonymi Fortunei 6-18 part, Pericarpium Citri Reticulatae 1.2-6 part, Radix Glycyrrhizae 1.2-6 part.
2. the production method that treatment women postpartum qi and blood according to claim 1 loses the oral Chinese medicine of deficient syndrome; it is characterized in that: the preparation method of granule is got the Radix Astragali; Radix Angelicae Sinensis; Radix Rehmanniae Preparata; the Rhizoma Atractylodis Macrocephalae; the Radix Paeoniae Alba; Rhizoma Chuanxiong; Caulis Seu Folium Euonymi Fortunei; Pericarpium Citri Reticulatae; Radix Glycyrrhizae nine flavor Chinese crude drugs are put in the multi-function extractor; decoct with water secondary; add for the first time 10 times of amounts; flood after 1 hour; decocted 2 hours; add for the second time 6 times of water gagings; decocted 2 hours; collecting decoction; filter with gauze or 50 order nylon leaching nets; filtrate moves to carries out normal pressure or concentrating under reduced pressure in the enrichment facility; to gained clear paste relative density be 1.10-1.15; measuring temperature is 65 ℃; put in the settling tank; adding ethanol makes and contains alcohol amount and reach 65%; left standstill 24 hours, and filtered with 50 order nylon leaching nets or filter press, filtrate moves in the multi-functional concentrated filling; reclaiming ethanol and being concentrated into relative density is 1.35-1.40; the measurement temperature is 80 ℃ a clear paste, adds sucrose; ethanol is put and has been made sugared type granule in the granulator, or adds dextrin; microcrystalline Cellulose; polyvinylpyrrolidone is an amount of; steviol glycosides is made sugar type granules; 80-100 ℃ of drying; the rearmounted total machine mixing that mixes of pelletizing machine arrangement, packing, promptly.
3. the production method that treatment women postpartum qi and blood according to claim 1 loses the oral Chinese medicine of deficient syndrome, it is characterized in that: by ratio of weight and the number of copies, get the Radix Astragali, Radix Angelicae Sinensis, Radix Rehmanniae Preparata, the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba, Rhizoma Chuanxiong, Caulis Seu Folium Euonymi Fortunei, Pericarpium Citri Reticulatae, Radix Glycyrrhizae nine flavor Chinese crude drugs are put in the multi-function extractor, decoct with water secondary, add for the first time 10 times of amounts, flood after 1 hour, decocted 2 hours, add for the second time 6 times of water gagings, decocted 2 hours, collecting decoction, filter with gauze or 50 order nylon leaching nets, filtrate moves to carries out normal pressure or concentrating under reduced pressure in the enrichment facility, to gained clear paste relative density be 1.10-1.15, measuring temperature is 65 ℃, puts in the settling tank, adds ethanol and makes and contain the alcohol amount and reach 65%, left standstill 24 hours, filter with 50 order nylon leaching nets or filter press, filtrate moves in the multi-functional concentrated filling, and reclaiming ethanol and being concentrated into relative density is 1.35-1.40, the measurement temperature is 80 ℃ a clear paste, add starch, the dextrin mixing, 60-100 ℃ of drying, pulverize, medicated powder adds microcrystalline Cellulose, polyvinylpyrrolidone is granulated, and is 80-100 ℃ of drying in temperature, granulate, add magnesium stearate at last, the Pulvis Talci mixing, tabletting, packing, promptly.
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| CN107693756A (en) * | 2017-09-14 | 2018-02-16 | 江苏七0七天然制药有限公司 | It is a kind of to be used to treat Chinese patent medical granule of menorrhalgia of cold-stagnation and blood-stasis type and preparation method thereof |
| CN119523916A (en) * | 2025-01-21 | 2025-02-28 | 北京东升制药有限公司 | Sugar-free blood-nourishing and nerve-calming granules and preparation method thereof |
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| CN1720977A (en) * | 2004-07-16 | 2006-01-18 | 西安安得药业有限责任公司 | Female nutritive tonic capsule |
| CN1850253A (en) * | 2006-03-10 | 2006-10-25 | 北京阜康仁生物制药科技有限公司 | Qianjin-Baoyun preparation and novel preparing method |
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| CN1720977A (en) * | 2004-07-16 | 2006-01-18 | 西安安得药业有限责任公司 | Female nutritive tonic capsule |
| CN1850253A (en) * | 2006-03-10 | 2006-10-25 | 北京阜康仁生物制药科技有限公司 | Qianjin-Baoyun preparation and novel preparing method |
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| 史桂荣.当归黄芪乌鸡汤治疗剖腹产后气血亏虚型恶漏不下8例分析.《中国误诊学杂志》.2009,第9卷(第6期), * |
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