CN103536674A - Medicament composition capable of preventing melanin tumor - Google Patents
Medicament composition capable of preventing melanin tumor Download PDFInfo
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- CN103536674A CN103536674A CN201310531703.2A CN201310531703A CN103536674A CN 103536674 A CN103536674 A CN 103536674A CN 201310531703 A CN201310531703 A CN 201310531703A CN 103536674 A CN103536674 A CN 103536674A
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Abstract
The invention discloses a medicament composition capable of preventing melanin tumor, and relates to the technical field of traditional Chinese medicines. The medicament composition is prepared from the traditional Chinese medicine raw materials in parts by weight: 30-40 parts of pomegranate bark, 30-40 parts of taxillus chinensis, 30-40 parts of hedyotis diffusa, 8-14 parts of spina gleditsiae, 16-22 parts of garden balsam seed, 16-22 parts of peach kernel, 20-28 parts of morinda officinalis and 20-28 parts of folium mori. The medicament composition disclosed by the invention is remarkable in effect of preventing melanin tumor; aiming at the situation of immunocom promise of patients caused by chemotherapeutic medicaments, the traditional Chinese medicine compound preparation can be used for enhancing the organism immunity and inhibit growth of melanin tumor, and is free of conspicuous side effect.
Description
Technical field
The pharmaceutical composition that the present invention relates to a kind of melanoma, belongs to technical field of Chinese medicines.
Background technology
Melanoma is the tumor being produced by skin and other organ melanocytes.Primary melanoma is by due to intraepidermal melanocytic hyperplasia, and it shows as the dense tuberosity increasing gradually of pigment, around can be around with blush.Though its sickness rate is low compared with basal cell carcinoma, squamous cell carcinoma, grade of malignancy is large, shifts and occurs early, and mortality rate is high.
The traditional Chinese medical science is to melanomatous treatment, and the < < Waike Zhengzong, Orthodox Manual of External Diseases > > of Ming Dynasty's Chen Shigong discusses the most detailed.Later ancient Chinese medicine doctor, particularly modern age doctor in a large amount of clinical practices, determined for oral administration combine with external treatment distinguish the pattern of controlling, shown that Chinese medicine melanoma really can improve symptom, life-saving, the effect of raising life quality.
Summary of the invention
The object of the invention is to by prescription again after Chinese medicine pharmacology is studied, a kind of melanoma better efficacy, instant effect, pharmaceutical composition that toxic and side effects is little are provided.
The object of the present invention is achieved like this:
A pharmaceutical composition for melanoma, wherein said pharmaceutical composition is prepared from by the traditional Chinese medicinal material raw materials of following weight portion: Pericarpium Granati 30-40 part, Herba Taxilli 30-40 part, Herba Hedyotidis Diffusae 30-40 part, Spina Gleditsiae 8-14 part, Semen Impatientis 16-22 part, Semen Persicae 16-22 part, Radix Morindae Officinalis 20-28 part, Folium Mori 20-28 part.
Further preferably, the pharmaceutical composition of melanoma as above, wherein said pharmaceutical composition is prepared from by the traditional Chinese medicinal material raw materials of following weight portion: Pericarpium Granati 33-36 part, Herba Taxilli 33-36 part, Herba Hedyotidis Diffusae 33-36 part, Spina Gleditsiae 10-12 part, Semen Impatientis 18-20 part, Semen Persicae 18-20 part, Radix Morindae Officinalis 23-25 part, Folium Mori 23-25 part.
Further preferably, the pharmaceutical composition of melanoma as above, wherein said pharmaceutical composition is prepared from by the traditional Chinese medicinal material raw materials of following weight portion: 34 parts of Pericarpium Granatis, 34 parts of Herba Taxillis, 34 parts of Herba Hedyotidis Diffusaes, 12 parts of Spina Gleditsiaes, 20 parts of Semen Impatientis, 20 parts, Semen Persicae, 24 parts of Radix Morindae Officinaliss, 24 parts, Folium Mori.
Further preferably, the pharmaceutical composition of melanoma as above, wherein said pharmaceutical composition is oral formulations.
Again further preferably, the pharmaceutical composition of melanoma as above, wherein said oral formulations is oral liquid, tablet, capsule or granule.
According to Chinese medicine Historical Data Data About, above-mentioned traditional Chinese medicinal material raw materials has following pharmacologically active and source:
Pericarpium Granati: astringing intestine to stop diarrhea, hemostasis, anthelmintic.Control chronic diarrhea, chronic dysentery, has blood in stool, proctoptosis, spermatorrhea, metrorrhagia, leukorrhagia, abdominal pain due to worm stagnation, scabies.Be selected from the peel of Punicaceae plant Punica granatum L..
Herba Taxilli: invigorating the liver and kidney; Bone and muscle strengthening; Wind-damp dispelling; Antiabortive.Main soreness of waist and knee joint; A little less than muscles and bones flaccidity; Limbs are hemiplegia; Rheumatic arthralgia; Head is wrong dizzy; Frequent fetal movement, metrostaxis.For rheumatic arthralgia, soreness of the waist and knees, muscles and bones is unable, and metrorrhagia warp is many, blood leaking in gestation, frequent fetal movement; Hypertension.Select the dry stem and branch with leaf of Loranthaceae plant Herba Taxilli Taxillus chinensis (DC.) Danser.
Herba Hedyotidis Diffusae: latin name Herba Hedyotis Diffusae, has the effect of heat-clearing and toxic substances removing, dampness removing; Cure mainly: dyspnea and cough due to lung-heat; Laryngopharynx swelling and pain; Intestinal carbuncle; Furuncle and phyma skin infection; Venom; The puckery pain of pyretic stranguria; Edema; Dysentery; Intestinal is scorching; Jaundice due to damp-heat; Cancerous protuberance.Be selected from the dry herb of Maguireothamnus speciosus Herba Hedyotidis Diffusae Hedyotis diffusa Willd..
Spina Gleditsiae: invigorate blood circulation, dispel the wind.Be used for the treatment of swollen ulcer drug, scrofula, skin ulcer rash stubborn dermatitis, puerperal hypogalactia, placenta retention, leprosy.Select the dry Spina jujubae of leguminous plant Fructus Gleditsia Gleditsia sinensis Lam..
Semen Impatientis: anticancer, scattered silt detumescence relieves internal heat.Removing blood stasis softening the hard mass, removing food stagnancy.Yong Yu WEIJIA mass in the abdomen, amenorrhea, dysphagic.Select the dry mature seed of Balsaminaceae plant Flos Impatientis Impatiens balsamina L..
Semen Persicae: blood circulation promoting and blood stasis dispelling, loosening bowel to relieve constipation, relieving cough and asthma.For amenorrhea, dysmenorrhea ， WEIJIA mass in the abdomen, injury from falling down, dryness of the intestine constipation.Select the dry mature seed of rosaceous plant Fructus Persicae Prunus persica (L.) Batsch or Prunus davidiana Prunus davidiana (Carr.) Franch..
Radix Morindae Officinalis: reinforcing the kidney and supporting YANG; Expelling wind and removing dampness; Bone and muscle strengthening.Impotence due to deficiency of the kidney; Seminal emission premature ejaculation; Few abdomen cold type of pain; Incontinence of urine; Cold womb is infertile; Anemofrigid-damp arthralgia; Soreness of the waist and knees; Rheumatism limb gas.Select the dry root of Maguireothamnus speciosus Radix Morindae Officinalis Morinda officinalis How.
Folium Mori: there is dispelling wind and heat pathogens, clearing away lung-heat and moistening for dryness, suppressing liver-YANG, liver heat removing and eyesight improving, the effect of cooling blood for hemostasis.Select the dried leaves of Moraceae Moraceae plant Mulberry Morus alba L..
The preparation method that above-mentioned each Chinese crude drug is prepared into compound preparation of the present invention, comprises the steps:
(1) get above-mentioned traditional Chinese medicinal material raw materials, clean roguing, dry, be ground into granule;
(2) granular Chinese crude drug is added to water and cover powder 2cm, soak 1-1.2h, pull medical material out and put multi-functional extraction and decoct with water secondary in filling with, add up for the first time the water of 10 times of amounts of medical material, decoct 2h, get decocting liquid, filter, add up for the second time the water of 7 times of amounts of medical material, decoct 1h, get twice decocting liquid and merge, filter the concentrated solution that while being concentrated into 90 ℃, relative density is 1.05;
(3) concentrated solution is set to 0 to-5 ℃ of deepfreeze 24h, cold preservation liquid is added to 0.3% filter aid kieselguhr, filter, filtrate reconcentration containing 5g crude drug amount, then adds 0.2% potassium sorbate to every milliliter, stir, set to 0-5 ℃ of deepfreeze 24h, cold preservation liquid is filtered to embedding, 105 ℃ of high temperature sterilizes, pack and obtain oral liquid.
The effect of the pharmaceutical composition melanoma the present invention relates to is remarkable, conventionally the situation that causes patient's immunologic hypofunction for chemotherapeutics, this compound Chinese medicinal preparation can enhancing human body immunity power, the growth of check melanin tumor, and non-evident effect, this has positive effect to improving immunologic function, the raising life quality of patients undergoing chemotherapy.
The specific embodiment
Be below specific embodiments of the invention, technical scheme of the present invention is done to further description, but protection scope of the present invention is not limited to these embodiment.Every do not deviate from the change of the present invention design or be equal to substitute include within protection scope of the present invention.
The preparation of embodiment 1 melanoma Chinese medicine oral liquid
Crude drug prescription: 3.4 kilograms of Pericarpium Granatis, 3.4 kilograms of Herba Taxillis, 3.4 kilograms of Herba Hedyotidis Diffusaes, 1.2 kilograms of Spina Gleditsiaes, 2 kilograms of Semen Impatientis, 2 kilograms, Semen Persicae, 2.4 kilograms of Radix Morindae Officinaliss, 2.4 kilograms, Folium Mori.
Preparation method:
(1) get above-mentioned traditional Chinese medicinal material raw materials, clean roguing, dry, be ground into granule;
(2) granular Chinese crude drug is added to water and cover powder 2cm, soak 1-1.2h, pull medical material out and put multi-functional extraction and decoct with water secondary in filling with, add up for the first time the water of 10 times of amounts of medical material, decoct 2h, get decocting liquid, filter, add up for the second time the water of 7 times of amounts of medical material, decoct 1h, get twice decocting liquid and merge, filter the concentrated solution that while being concentrated into 90 ℃, relative density is 1.05;
(3) concentrated solution is set to 0 to-5 ℃ of deepfreeze 24h, cold preservation liquid is added to 0.3% filter aid kieselguhr, filter, filtrate reconcentration containing 5g crude drug amount, then adds 0.2% potassium sorbate to every milliliter, stir, set to 0-5 ℃ of deepfreeze 24h, cold preservation liquid is filtered to embedding, 105 ℃ of high temperature sterilizes, pack and obtain oral liquid.
The preparation of embodiment 2 melanoma Chinese medicine oral liquid
Crude drug prescription: 3 kilograms of Pericarpium Granatis, 3.8 kilograms of Herba Taxillis, 4 kilograms of Herba Hedyotidis Diffusaes, 0.8 kilogram of Spina Gleditsiae, 1.6 kilograms of Semen Impatientis, 2.2 kilograms, Semen Persicae, 2.8 kilograms of Radix Morindae Officinaliss, 2 kilograms, Folium Mori.
Preparation method:
(1) get above-mentioned traditional Chinese medicinal material raw materials, clean roguing, dry, be ground into granule;
(2) granular Chinese crude drug is added to water and cover powder 2cm, soak 1-1.2h, pull medical material out and put multi-functional extraction and decoct with water secondary in filling with, add up for the first time the water of 10 times of amounts of medical material, decoct 2h, get decocting liquid, filter, add up for the second time the water of 7 times of amounts of medical material, decoct 1h, get twice decocting liquid and merge, filter the concentrated solution that while being concentrated into 90 ℃, relative density is 1.05;
(3) concentrated solution is set to 0 to-5 ℃ of deepfreeze 24h, cold preservation liquid is added to 0.3% filter aid kieselguhr, filter, filtrate reconcentration containing 5g crude drug amount, then adds 0.2% potassium sorbate to every milliliter, stir, set to 0-5 ℃ of deepfreeze 24h, cold preservation liquid is filtered to embedding, 105 ℃ of high temperature sterilizes, pack and obtain oral liquid.
The preparation of embodiment 3 melanoma Chinese medicine oral liquid
Crude drug prescription: 4 kilograms of Pericarpium Granatis, 3.1 kilograms of Herba Taxillis, 3 kilograms of Herba Hedyotidis Diffusaes, 1.4 kilograms of Spina Gleditsiaes, 2 kilograms of Semen Impatientis, 1.6 kilograms, Semen Persicae, 2 kilograms of Radix Morindae Officinaliss, 2.8 kilograms, Folium Mori.
Preparation method:
(1) get above-mentioned traditional Chinese medicinal material raw materials, clean roguing, dry, be ground into granule;
(2) granular Chinese crude drug is added to water and cover powder 2cm, soak 1-1.2h, pull medical material out and put multi-functional extraction and decoct with water secondary in filling with, add up for the first time the water of 10 times of amounts of medical material, decoct 2h, get decocting liquid, filter, add up for the second time the water of 7 times of amounts of medical material, decoct 1h, get twice decocting liquid and merge, filter the concentrated solution that while being concentrated into 90 ℃, relative density is 1.05;
(3) concentrated solution is set to 0 to-5 ℃ of deepfreeze 24h, cold preservation liquid is added to 0.3% filter aid kieselguhr, filter, filtrate reconcentration containing 5g crude drug amount, then adds 0.2% potassium sorbate to every milliliter, stir, set to 0-5 ℃ of deepfreeze 24h, cold preservation liquid is filtered to embedding, 105 ℃ of high temperature sterilizes, pack and obtain oral liquid.
Embodiment 4 pharmaceutical composition of the present invention rings the tumor ghost image of melanoma model mice
Chinese medicine composition of the present invention is for the effect highly significant of melanoma, and in order to verify its effect, the inventor evaluates by the pharmacodynamics to this medicine on melanoma mouse model, and for clinical practice provides experimental basis, concrete process of the test is as follows:
30 of C57/BL6 mices, l8～20 g, female.Every mouse armpit subcutaneous injection mouse melanoma B16 cell 2 * 10
6individual, be divided at random following three groups: blank group, Chinese drug-treated group and positive controls.Within the 2nd day, rise as follows and dosed administration:
Blank group: adopt treatment fluid (being mixed with the blank coagulant liquid of 2% Sodium Tvlose with distilled water) every mice 0.5ml of gavage;
Positive controls: adopt every mice 0.5ml for the treatment of fluid (the cyclophosphamide powder for injection of 200mg/ bottle, faces the cyclophosphamide Injection that the used time is mixed with 1mg/ml) lumbar injection;
Chinese drug-treated group: adopt treatment fluid (oral liquid with embodiment 1 preparation is mixed with 2% Sodium Tvlose coagulant liquid) every mice 0.5ml of gavage;
Each is organized administration and is every day 1 time, totally 25 times.Within the 26th day, put to death mice, mouse tumor weight change is respectively organized in observation.Result of the test is referring to table 1.
After table 1 off-test, respectively organize the tumor anharmonic ratio of mice
Compare with blank group,
* p< 0.01.
Result of the test by table 1 can find out, Chinese medicine oral liquid of the present invention to melanoma mouse stomach after, more blank group of state and the positive controls of mice are good; To the different treatment group tumor weights Epidemiological Analysis that takes statistics, result shows, heavy more blank group of the tumor of each administration group mice has significant reduction, have significant difference (
p< 0.01).
Claims (5)
1. a pharmaceutical composition for melanoma, is characterized in that: described pharmaceutical composition is prepared from by the traditional Chinese medicinal material raw materials of following weight portion: Pericarpium Granati 30-40 part, Herba Taxilli 30-40 part, Herba Hedyotidis Diffusae 30-40 part, Spina Gleditsiae 8-14 part, Semen Impatientis 16-22 part, Semen Persicae 16-22 part, Radix Morindae Officinalis 20-28 part, Folium Mori 20-28 part.
2. the pharmaceutical composition of melanoma according to claim 1, is characterized in that: described pharmaceutical composition is prepared from by the traditional Chinese medicinal material raw materials of following weight portion: Pericarpium Granati 33-36 part, Herba Taxilli 33-36 part, Herba Hedyotidis Diffusae 33-36 part, Spina Gleditsiae 10-12 part, Semen Impatientis 18-20 part, Semen Persicae 18-20 part, Radix Morindae Officinalis 23-25 part, Folium Mori 23-25 part.
3. the pharmaceutical composition of melanoma according to claim 2, is characterized in that: described pharmaceutical composition is prepared from by the traditional Chinese medicinal material raw materials of following weight portion: 34 parts of Pericarpium Granatis, 34 parts of Herba Taxillis, 34 parts of Herba Hedyotidis Diffusaes, 12 parts of Spina Gleditsiaes, 20 parts of Semen Impatientis, 20 parts, Semen Persicae, 24 parts of Radix Morindae Officinaliss, 24 parts, Folium Mori.
4. according to the pharmaceutical composition of the melanoma described in claim 1-3 any one, it is characterized in that: described pharmaceutical composition is oral formulations.
5. the pharmaceutical composition of melanoma according to claim 4, is characterized in that: described oral formulations is oral liquid, tablet, capsule or granule.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104257716A (en) * | 2014-09-19 | 2015-01-07 | 吉林吉福参生物开发股份有限公司 | Medicament for treating melanoma and preparation method thereof |
| CN105106869A (en) * | 2015-09-30 | 2015-12-02 | 青岛友诚高新技术有限公司 | Traditional Chinese medicine composition for treating melanoma and preparation method of traditional Chinese medicine composition |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1422642A (en) * | 2001-12-04 | 2003-06-11 | 何文法 | Series Chinese medicinal composition for treating tumor |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1422642A (en) * | 2001-12-04 | 2003-06-11 | 何文法 | Series Chinese medicinal composition for treating tumor |
Non-Patent Citations (2)
| Title |
|---|
| 刘因华: "抗肿瘤药物的研究现状与发展前景", 《中国医药指南》 * |
| 程培育等: "郁仁存治疗恶性黑色素瘤经验", 《北京中医药》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104257716A (en) * | 2014-09-19 | 2015-01-07 | 吉林吉福参生物开发股份有限公司 | Medicament for treating melanoma and preparation method thereof |
| CN105106869A (en) * | 2015-09-30 | 2015-12-02 | 青岛友诚高新技术有限公司 | Traditional Chinese medicine composition for treating melanoma and preparation method of traditional Chinese medicine composition |
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Effective date of registration: 20141229 Address after: 226400, a group of 56, Rainbow Village, dug Town, Rudong County, Jiangsu Province Patentee after: Gu Xiang Address before: 276017 Linyi hi tech Industrial Development Zone, innovation building, building 2, Di Di, Shandong science and Technology Information Service Center Patentee before: Yang Xianhua |