CN103054990B - Traditional Chinese medicine for treating functional abdominal pain in children and preparation method thereof - Google Patents
Traditional Chinese medicine for treating functional abdominal pain in children and preparation method thereof Download PDFInfo
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- CN103054990B CN103054990B CN201210573485.4A CN201210573485A CN103054990B CN 103054990 B CN103054990 B CN 103054990B CN 201210573485 A CN201210573485 A CN 201210573485A CN 103054990 B CN103054990 B CN 103054990B
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Abstract
The invention aims to provide a traditional Chinese medicine for treating functional abdominal pain in children and a preparation method thereof. The traditional Chinese medicine comprises medicinal evodia fruit, clove, banksia rose, cassia bark and atractylodes rhizome. The traditional Chinese medicine provided by the invention employs reasonably combined Chinese herbal medicines and has the advantages of steady medicine properties, no toxic and side effects and comprehensive action; the traditional Chinese medicine is externally applied for treating functional abdominal pain in children, so a therapeutic method is easy and convenient; and through cooperation with acupoint massage, a more ideal effect of the traditional Chinese medicine can be realized.
Description
Technical field
The present invention relates to field of medicaments, be specifically related to a kind of Chinese medicine for the treatment of Functional Abdominal Pain in Children and preparation method thereof.
Background technology
Functional Abdominal Pain in Children accounts for the 50%-70% of Children bellyache, and along with change and the growth in the living standard of social environment, repeatedly suffering from cold and liking food raw food raises the sickness rate of primary disease, has increased the misery of infant and the head of a family's anxiety.Modern medicine lacks the foundation of organic disease based on primary disease; emphasize cognition-behavior-psychotherapy of infant and the head of a family thereof can reduce stomachache degree; alleviate stomachache even completely; 6-12 month follow up a case by regular visits to seldom recurred; reduce the impact of stomachache on daily routines, increased the satisfaction of Parents with Children to treatment.Drug treatment western modern medicine has significant limitation to the treatment of primary disease, and side effect is larger.Therefore, to primary disease pathogenesis and treatment, need carry out more deep research.
Chinese medicine is thought, child's " the spleen tending to insufficiency usually ", and internal organs are tender and lovely, and body does not fill, and diet can not self-regulated, easily forms gastrointestinal dysfunction.One and exopathogen direct attack, the retardance of condensing, stagnates breast food, dysfunction of the spleen in transportation. stomach-QI being unable to descend normally, disorder of QI movement, stagnation of QI and blood may bring about pain.Therefore, Chinese medicine primary disease has its distinctive feature, determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, as cold person's using warming therapy, real person logical etc., can reach the effect of " effecting a permanent cure ".Often adopt clinically oral medicinal herb and coordinate Chinese medicine patch umbilicus to treat, but the difficulty of taking medicine during the outbreak of infant stomachache has limited the therapeutic effect to Functional Abdominal Pain in Children.
Summary of the invention
The object of this invention is to provide a kind of Chinese medicine for the treatment of Functional Abdominal Pain in Children and preparation method thereof, the Chinese medicine for the treatment of Functional Abdominal Pain in Children provided by the present invention is used by external application completely, can treat preferably Functional Abdominal Pain in Children, have no side effect, safe and reliable.
The Chinese medicine for the treatment of Functional Abdominal Pain in Children of the present invention is to be prepared from by the raw material that comprises following weight portion:
Fructus Evodiae 10～50 Flos Caryophylli 10～50 Radix Aucklandiae 10～50
Cortex Cinnamomi 10～50 Rhizoma Atractylodis 10～50.
The Chinese medicine for the treatment of Functional Abdominal Pain in Children of the present invention, its preferred version is to be prepared from by the raw material that comprises following weight portion:
Fructus Evodiae 20～40 Flos Caryophylli 20～40 Radix Aucklandiae 20～40
Cortex Cinnamomi 20～40 Rhizoma Atractylodis 20～40.
The Chinese medicine for the treatment of Functional Abdominal Pain in Children of the present invention, its further preferred version is to be prepared from by the raw material that comprises following weight portion:
Fructus Evodiae 30 Flos Caryophylli 30 Radix Aucklandiae 30
Cortex Cinnamomi 30 Rhizoma Atractylodis 30.
The Chinese medicine for the treatment of Functional Abdominal Pain in Children of the present invention, its active component is prepared from by the following method:
Get whole 5 taste medical materials, add and be equivalent to the alcohol dipping 12～48 hours that the volume by volume concentration of 1～2 times of this 5 taste medical material gross weight is 40%～60%, then the ethanol that is 40%～60% with volume by volume concentration carries out percolation with the speed that accounts for raw material gross weight 0.2%～0.6% per minute, collection is equivalent to the percolate that this 5 taste medical material gross weight 5-10 doubly measures, reclaim ethanol, be evaporated to and be equivalent to 1～2 times of 5 taste medical material gross weights, filter, obtain active component.
The Chinese medicine for the treatment of Functional Abdominal Pain in Children of the present invention, its active component is to be prepared from by following method for optimizing:
Get whole 5 taste medical materials, add and be equivalent to the alcohol dipping 24～36 hours that the volume by volume concentration of 1～2 times of this 5 taste medical material gross weight is 50%～56%, then the ethanol that is 50%～56% with volume by volume concentration carries out percolation with the speed that accounts for raw material gross weight 0.3%～0.5% per minute, collection is equivalent to the percolate that this 5 taste medical material gross weight 5-10 doubly measures, reclaim ethanol, be evaporated to and be equivalent to 1～2 times of 5 taste medical material gross weights, filter, obtain active component.
The Chinese medicine for the treatment of Functional Abdominal Pain in Children of the present invention, can coordinate with pharmaceutically acceptable carrier, makes various common dosage forms.
In the present invention, Chinese medicine details is as follows:
Fructus Evodiae
This product is rutaceae Fructus Evodiae Evodia rutaecarpa(Juss.) Benth., Shi Hu Evodia rutaecarpa(Juss.) Benth. var. officinalis (Dode) Huang or dredge a dry almost ripe fruit of hair Fructus Evodiae Evodia rutaecarpa (Juss.) Benth. var. bodinieri (Dode) Huang.When 8～November, fruit not yet ftractureed, cut Fruit branch, dry or cold drying, except impurity such as debranching, leaf, carpopodiums.Acrid in the mouth, hardship, hot in nature; Slightly poisonous.Return liver, spleen, stomach, kidney channel.Function dispersing cold for relieving pain, stopping nausea and vomiting by lowering the adverse flow of QI, supporing yang antidiarrheal.For headache due to JUE YIN disorder, colic of cold type stomachache, the disturbance of lower legs due to pathogenic cold and dampness, dysmenorrhea, abdominal pain during menstruation, abdominal distention, vomiting acid regurgitation, Diarrhoea, external treatment aphtha; Hypertension.
Flos Caryophylli
This product is the dry flower of plant clove of myrtaceae Eugenia caryophyllata Thunb..When alabastrum turns red by green, pluck, dry.Acrid in the mouth, warm in nature.Return spleen, stomach, lung, kidney channel.Function warming middle-JIAO to send down the adverse QI, reinforcing the kidney and supporting YANG.For Deficiency and coldness of spleen and stomach, singultus vomiting, lack of appetite and vomiting, trusted subordinate's cold type of pain, impotence due to deficiency of the kidney.
The Radix Aucklandiae
This product is the dry root of feverfew Radix Aucklandiae Aucklandia lappa Decne..Autumn, two seasons of winter excavate, and remove silt and fibrous root, cutting, and large vertical profile again becomes lobe, after being dried, hits rough bark.The Radix Aucklandiae is the common name of feverfew Saussurea lappa Clarke and Radix Vladimiriae.Saussurea lappa Clarke (formal name used at school: Saussurea costus), have another name called Radix Aucklandiae (Radix Vladimiriae) or Radix Aristolochiae, belong to Compositae Genus Saussurea.Radix Vladimiriae (formal name used at school: Dolomiaea souliei) be the plant of Compositae Dolomiaea.Acrid in the mouth, hardship, warm in nature.Return spleen, stomach, large intestine, three warmers, gallbladder meridian.Function promoting the circulation of QI to relieve pain, strengthening the spleen to promote digestion.For breast gastral cavity distending pain, heavy after dysentery, food stagnation does not disappear, anorexia.The real intestinal antidiarrheal of Radix Aucklandiae (roasted).Stomachache is used for having loose bowels.
Cortex Cinnamomi
This product is the dry bark of canella Cortex Cinnamomi Cinnamomum cassia Presl.More than stripping autumn, dry in the shade.Acrid in the mouth, sweet, extremely hot in nature.Return kidney, spleen, the heart, Liver Channel.It is supporing yang that function is mended fire, guiding fire to origin, dispersing cold for relieving pain, promoting the flow of QI-blood by warming the meridian.For sexual impotence cold womb, chills and pain of the waist and kness, suffers from a deficiency of the kidney and breathes heavily, upward floating of YANG in deficiency condition, and dizzy conjunctival congestion, trusted subordinate's cold type of pain, deficiency and coldness is vomited and diarrhoea, colic of cold type stomachache, dysmenorrhea amenorrhea.
Rhizoma Atractylodis
This product is the dry rhizome of feverfew Atractylodes lancea (Thunb.) DC. Atractylodes lancea (Thunb.) DC. or Atractylis chinensis Atractylodes chinensis (DC.) Koidz..Spring, Qiu Erji excavate, and remove silt, dry, and hit fibrous root.Acrid in the mouth, hardship, warm in nature.Return spleen, stomach, Liver Channel.Function is drying damp and strengthening spleen, expelling wind and cold, improving eyesight.For retention of dampness in middle-JIAO, distension and fullness in the abdomen, has loose bowels, edema, and beriberi flaccidity is preesed, rheumatic arthralgia, anemofrigid cold, nyctalopia, eyes dusk is puckery.
The present invention finds out on to the understanding of Functional Abdominal Pain in Children basic pathogenesis.The basic pathogenesis of Functional Abdominal Pain in Children is: the retardance of condensing, stagnates breast food, dysfunction of the spleen in transportation. stomach-QI being unable to descend normally, disorder of QI movement, stagnation of QI and blood may bring about pain.Fructus Evodiae dispersing cold for relieving pain of the present invention; Flos Caryophylli warming middle-JIAO to send down the adverse QI, reinforcing the kidney and supporting YANG; Radix Aucklandiae promoting the circulation of QI to relieve pain, strengthening the spleen to promote digestion; Cortex Cinnamomi dispersing cold for relieving pain, promoting the flow of QI-blood by warming the meridian; Rhizoma Atractylodis are drying damp and strengthening spleen, expelling wind and cold; The collocation of all medicines, play altogether spleen reinforcing and in, invigorating the spleen and regulating the stomach, the effect of relieving spasm to stop pain.The present invention arranges in pairs or groups rationally, adopts external application for curing, and Therapeutic Method is easy, and the property of medicine is steady, and effect comprehensively, coordinates acupuncture point to massage and can obtain more preferably effect.
As the clinical test results of embodiment 7 and embodiment 8 shows, Chinese medicine of the present invention, by external application for curing Functional Abdominal Pain in Children, has good effect, and effective percentage reaches 94.64%; And in the clinical process treating, have no toxic and side effects, safe and reliable.
Chinese medicine provided by the invention has overcome the defect of prior art, with respect to prior art, has outstanding substantive distinguishing features and progressive significantly.
The specific embodiment
Embodiment 1
Fructus Evodiae 100g Flos Caryophylli 200g Radix Aucklandiae 100g
Cortex Cinnamomi 100g Rhizoma Atractylodis 200g
Get whole 5 taste medical materials, the alcohol dipping that the volume by volume concentration that adds 700g is 40% 12 hours, then the ethanol that is 40% with volume by volume concentration carries out percolation with the speed that accounts for raw material gross weight 0.2% per minute, collect the percolate of 3500g, reclaim ethanol, be evaporated to 700g, filter, obtain active component.
Embodiment 2
Fructus Evodiae 500g Flos Caryophylli 300g Radix Aucklandiae 500g
Cortex Cinnamomi 300g Rhizoma Atractylodis 200g
Get whole 5 taste medical materials, the alcohol dipping that the volume by volume concentration that adds 3600g is 60% 48 hours, then the ethanol that is 60% with volume by volume concentration carries out percolation with the speed that accounts for raw material gross weight 0.6% per minute, collect the percolate of 18000g, reclaim ethanol, be evaporated to 3600g, filter, obtain active component.
Active component is mixed homogeneously with appropriate antioxidant, propellant, obtain aerosol of the present invention.
Embodiment 3
Fructus Evodiae 200g Flos Caryophylli 200g Radix Aucklandiae 300g
Cortex Cinnamomi 300g Rhizoma Atractylodis 200g
Get whole 5 taste medical materials, at 50-60 ℃ of cold drying 48 h, after mixing, pulverize and cross sieve No. 7, low temperature interstitial sterilization treatment 48 h, subpackage is standby, obtains powder agent of the present invention.
Embodiment 4
Fructus Evodiae 300g Flos Caryophylli 300g Radix Aucklandiae 300g
Cortex Cinnamomi 300g Rhizoma Atractylodis 300g
Get whole 5 taste medical materials, the alcohol dipping that the volume by volume concentration that adds 2250g is 56% 24 hours, then the ethanol that is 56% with volume by volume concentration carries out percolation with the speed that accounts for raw material gross weight 0.4% per minute, collect the percolate of 12000g, reclaim ethanol, be evaporated to 2500g, filter, obtain active component.
The extractum that when active component is concentrated into 80 ℃, relative density is 1.21, coordinates with appropriate water-soluble base, stirs, and obtains ointment of the present invention.
Embodiment 5
Fructus Evodiae 100g Flos Caryophylli 500g Radix Aucklandiae 100g
Cortex Cinnamomi 500g Rhizoma Atractylodis 100g
Get whole 5 taste medical materials, the alcohol dipping that the volume by volume concentration that adds 2210g is 53% 36 hours, then the ethanol that is 56% with volume by volume concentration carries out percolation with the speed that accounts for raw material gross weight 0.4% per minute, collect the percolate of 11700g, reclaim ethanol, be evaporated to 1690g, filter, obtain active component.
Active component adds the adjuvants such as appropriate adhesive, wetting agent, filler, stirs, and coats on back lining materials, obtains gel rubber plaster unguentum of the present invention.
Embodiment 6
Fructus Evodiae 400g Flos Caryophylli 500g Radix Aucklandiae 100g
Cortex Cinnamomi 200g Rhizoma Atractylodis 400g
Get whole 5 taste medical materials, the alcohol dipping that the volume by volume concentration that adds 1920g is 55% 18 hours, the ethanol that is then 58% with volume by volume concentration carries out percolation with the speed that accounts for raw material total weight parts 0.3% per minute, collect the percolate of 11200g, stir, filter, obtain tincture of the present invention.
Embodiment 7
1, case selection: patient age scope is between 3-7 between year, and the course of disease time is more than 2 months.
2, diagnostic criteria
Reference Applied Clinical Pediatrics magazine < < child functional gastrointestinal disorder in 2008: Rome III criteria for classification > >.Must comprise following:
(1) ictal or persistence stomachache;
(2) do not reach the standard of other functional gastrointestinal disorders (FGID);
(3) can not explain the evidence of inflammatory, dissection, Developmental and Metabolic Disorder or the tumor aspect of patient's symptom.
Can at least 1 time/week, at least ability diagnosis in lasting 2 months.
3, curative effect determinate standard:
Cure: stomachache disappears, in 1 week, do not reaccess:
Effective: stomachache degree obviously alleviates, seizure frequency reduces more than 75%, and the persistent period significantly shortens;
Effective: stomachache degree alleviates;
Invalid: stomachache and other symptoms are without improvement.
4, drug use method
Treatment group, with the medicine of the embodiment of the present invention 4, is coated on gauze, with immobilization with adhesive tape, sticks the SHENQUE acupoint in infant umbilicus god, every day 1 time, and each medicine that is equivalent to crude drug amount 25g that uses, continuous 7 days was 1 course for the treatment of.Can repetitive therapy 1-2 a course for the treatment of.
Matched group: give oral Anisodamine 0.3～0.5 mg/(kgd), minute 3 clothes, serve on drug withdrawal on the 3rd, and oral Yuanhuzhitong Dropping Pills and microbial ecological agent 1-2 grain, serve on treatment in 1 week simultaneously.
5, clinical treatment result
In Table 1
The contrast of table 1 clinical therapeutic efficacy
| Group | Number of cases | Cure | Effective | Effectively | Invalid | Total effective rate (%) |
| Treatment group | 56 | 46 | 4 | 3 | 3 | 94.64 |
| Matched group | 31 | 16 | 5 | 3 | 7 | 83.33 |
Embodiment 8
1, patient Wu * *, women, 6 years old, people from Liuzhou city, Guangxi province, the course of disease 2 years, main suit is because of " Recurrent Abdominal Pain 2 years, then send out 2 days and " examine.Through the present invention treatment, vomiting in the 1st day, stomachache alleviate, and vomiting in 2 days stops, stomachache disappearance in 3 days, and 4 days spirit, appetite is as usual, adhere to providing follow-up care for a patient and do not recur for 1 week again.
2, patient Peng * *, female, 5 years old, people from Liuzhou, the course of disease 1 year, because " Recurrent Abdominal Pain more than 1 year, then send out 1 day " examines.Through the present invention, treat the 2nd day symptom and alleviate, within the 5th day, stomachache disappears, and continual cure is followed up a case by regular visits to symptom in 1 week and do not recurred again.
3, patient Liao * *, female, 7 years old, people from Liuzhou city, Guangxi province, course of disease February, because of " Recurrent Abdominal Pain February, then send out and increase the weight of 3 days and " examine, treat 3 days symptoms obviously alleviate through the present invention, treat and return to one's perfect health after 1 week.
4, patient's beam * *, male, 6 years old, people from Liuzhou city, Guangxi province, course of disease February, examined because of " abdominal pain February, increase the weight of 1 day ", through the present invention, treats remission in 3 days, continual cure 1 week, follows up a case by regular visits to symptom more not repeatedly.
5, patient yellow * *, female, 5 years old 10 months, people from Liuzhou city, Guangxi province, course of disease March, examined because of " abdominal pain March, then send out 1 day ", through the present invention, treats remission in 3 days, continual cure 1 week, follows up a case by regular visits to symptom more not repeatedly.
Claims (5)
1. the purposes of following Chinese medicine composition in the medicine of preparation treatment children's functional abdominal pain:
Fructus Evodiae 10～50 Flos Caryophylli 10～50 Radix Aucklandiae 10～50
Cortex Cinnamomi 10～50 Rhizoma Atractylodis 10～50.
2. purposes as claimed in claim 1, is characterized in that described Chinese medicine composition is:
Fructus Evodiae 20～40 Flos Caryophylli 20～40 Radix Aucklandiae 20～40
Cortex Cinnamomi 20～40 Rhizoma Atractylodis 20～40.
3. purposes as claimed in claim 2, is characterized in that described Chinese medicine composition is:
Fructus Evodiae 30 Flos Caryophylli 30 Radix Aucklandiae 30
Cortex Cinnamomi 30 Rhizoma Atractylodis 30.
4. purposes as claimed in claim 1, is characterized in that the active component of described Chinese medicine composition is prepared from by the following method:
Get whole 5 taste medical materials, add and be equivalent to the alcohol dipping 12～48 hours that the volume by volume concentration of 1～2 times of this 5 taste medical material gross weight is 40%～60%, then the ethanol that is 40%～60% with volume by volume concentration carries out percolation with the speed that accounts for raw material gross weight 0.2%～0.6% per minute, collection is equivalent to the percolate that this 5 taste medical material gross weight 5-10 doubly measures, reclaim ethanol, be evaporated to and be equivalent to 1～2 times of 5 taste medical material gross weights, filter, obtain active component.
5. purposes as claimed in claim 1, is characterized in that the active component of described Chinese medicine composition is prepared from by the following method:
Get whole 5 taste medical materials, add and be equivalent to the alcohol dipping 24～36 hours that the volume by volume concentration of 1～2 times of this 5 taste medical material gross weight is 50%～56%, then the ethanol that is 50%～56% with volume by volume concentration carries out percolation with the speed that accounts for raw material gross weight 0.3%～0.5% per minute, collection is equivalent to the percolate that this 5 taste medical material gross weight 5-10 doubly measures, reclaim ethanol, be evaporated to and be equivalent to 1～2 times of 5 taste medical material gross weights, filter, obtain active component.
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| CN105126007B (en) * | 2015-10-13 | 2018-12-25 | 广州中医药大学 | A kind of patch for treating baby diarrhea |
| CN105169205B (en) * | 2015-10-13 | 2018-12-25 | 广州中医药大学 | A kind of navel paster for treating baby diarrhea |
| CN105456457A (en) * | 2016-01-08 | 2016-04-06 | 牙述东 | Medicine for treating colic of horses |
| CN107823612A (en) * | 2017-12-05 | 2018-03-23 | 广州中医药大学第附属医院 | A kind of children transport spleen application and dissipate and its apply |
| CN112618633A (en) * | 2021-01-18 | 2021-04-09 | 广州中医药大学第一附属医院 | Traditional Chinese medicine composition and application thereof |
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| Title |
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| 张俊庭.吴萸散敷脐治疗小儿腹泻.《中国中医特治新法大全》.1996, * |
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