CN103054990A - Traditional Chinese medicine for treating functional abdominal pain in children and preparation method thereof - Google Patents
Traditional Chinese medicine for treating functional abdominal pain in children and preparation method thereof Download PDFInfo
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- CN103054990A CN103054990A CN2012105734854A CN201210573485A CN103054990A CN 103054990 A CN103054990 A CN 103054990A CN 2012105734854 A CN2012105734854 A CN 2012105734854A CN 201210573485 A CN201210573485 A CN 201210573485A CN 103054990 A CN103054990 A CN 103054990A
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Abstract
The invention aims to provide a traditional Chinese medicine for treating functional abdominal pain in children and a preparation method thereof. The traditional Chinese medicine comprises medicinal evodia fruit, clove, banksia rose, cassia bark and atractylodes rhizome. The traditional Chinese medicine provided by the invention employs reasonably combined Chinese herbal medicines and has the advantages of steady medicine properties, no toxic and side effects and comprehensive action; the traditional Chinese medicine is externally applied for treating functional abdominal pain in children, so a therapeutic method is easy and convenient; and through cooperation with acupoint massage, a more ideal effect of the traditional Chinese medicine can be realized.
Description
Technical field
The present invention relates to field of medicaments, be specifically related to a kind of Chinese medicine for the treatment of Functional Abdominal Pain in Children and preparation method thereof.
Background technology
Functional Abdominal Pain in Children accounts for the 50%-70% of Children bellyache, and along with change and the growth in the living standard of social environment, repeatedly suffering from cold and liking food raw food raises the sickness rate of primary disease, has increased the misery of infant and the head of a family's anxiety.Modern medicine lacks the foundation of organic disease based on primary disease; cognition-the behavior-psychotherapy to infant and the head of a family thereof of emphasizing can reduce the stomachache degree; even fully alleviation stomachache; 6-12 month follow up a case by regular visits to seldom recurred; reduce the impact of stomachache on daily routines, increased the satisfaction of Parents with Children to treatment.The drug treatment western modern medicine has significant limitation to the treatment of primary disease, and side effect is larger.Therefore, need carry out more deep research to primary disease pathogenesis and treatment.
Chinese medicine is thought, child's " the spleen tending to insufficiency usually ", and internal organs are tender and lovely, and body does not fill, and diet can not self-regulated, forms easily gastrointestinal dysfunction.One and the exopathogen direct attack, the retardance of condensing makes the breast food stagnate dysfunction of the spleen in transportation. stomach-QI being unable to descend normally, disorder of QI movement, stagnation of QI and blood may bring about pain.Therefore, the Chinese medicine primary disease has its distinctive feature, determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, such as cold person's using warming therapy, real person logical etc., can reach the effect of " effecting a permanent cure ".Often adopt clinically oral medicinal herb and cooperate the Chinese medicine patch umbilicus to treat, the difficulty of taking medicine when showing effect but infant is suffered from abdominal pain has limited the therapeutic effect to Functional Abdominal Pain in Children.
Summary of the invention
The purpose of this invention is to provide a kind of Chinese medicine for the treatment of Functional Abdominal Pain in Children and preparation method thereof, the Chinese medicine for the treatment of Functional Abdominal Pain in Children provided by the present invention uses by external application fully, can treat preferably Functional Abdominal Pain in Children, have no side effect, safe and reliable.
The Chinese medicine for the treatment of Functional Abdominal Pain in Children of the present invention is to be prepared from by the raw material that comprises following weight portion:
Fructus Evodiae 10～50 Flos Caryophyllis 10～50 Radix Aucklandiae 10～50
Cortex Cinnamomi 10～50 Rhizoma Atractylodis 10～50.
The Chinese medicine for the treatment of Functional Abdominal Pain in Children of the present invention, its preferred version are to be prepared from by the raw material that comprises following weight portion:
Fructus Evodiae 20～40 Flos Caryophyllis 20～40 Radix Aucklandiae 20～40
Cortex Cinnamomi 20～40 Rhizoma Atractylodis 20～40.
The Chinese medicine for the treatment of Functional Abdominal Pain in Children of the present invention, its further preferred version is to be prepared from by the raw material that comprises following weight portion:
Fructus Evodiae 30 Flos Caryophyllis 30 Radix Aucklandiae 30
Cortex Cinnamomi 30 Rhizoma Atractylodis 30.
The Chinese medicine for the treatment of Functional Abdominal Pain in Children of the present invention, its active component is prepared from by the following method:
Get whole 5 flavor medical materials, added the volume by volume concentration be equivalent to 1～2 times of this 5 flavor medical material gross weight and be 40%～60% alcohol dipping 12～48 hours, then be that 40%～60% ethanol carries out percolation with the speed that per minute accounts for raw material gross weight 0.2%～0.6% with volume by volume concentration, collection is equivalent to the percolate that this 5 flavor medical material gross weight 5-10 doubly measures, Recycled ethanol, be evaporated to 1～2 times that is equivalent to 5 flavor medical material gross weights, filter, obtain active component.
The Chinese medicine for the treatment of Functional Abdominal Pain in Children of the present invention, its active component are to be prepared from by following method for optimizing:
Get whole 5 flavor medical materials, added the volume by volume concentration be equivalent to 1～2 times of this 5 flavor medical material gross weight and be 50%～56% alcohol dipping 24～36 hours, then be that 50%～56% ethanol carries out percolation with the speed that per minute accounts for raw material gross weight 0.3%～0.5% with volume by volume concentration, collection is equivalent to the percolate that this 5 flavor medical material gross weight 5-10 doubly measures, Recycled ethanol, be evaporated to 1～2 times that is equivalent to 5 flavor medical material gross weights, filter, obtain active component.
The Chinese medicine for the treatment of Functional Abdominal Pain in Children of the present invention can cooperate with pharmaceutically acceptable carrier, makes various common dosage forms.
The Chinese medicine details is as follows among the present invention:
Fructus Evodiae
This product is rutaceae Fructus Evodiae Evodia rutaecarpa(Juss.) Benth., Shi Hu Evodia rutaecarpa(Juss.) Benth. var. officinalis (Dode) Huang or dredge the dry almost ripe fruit of hair Fructus Evodiae Evodia rutaecarpa (Juss.) Benth. var. bodinieri (Dode) Huang.When 8～November, fruit not yet ftractureed, cut Fruit branch, dry or cold drying, except impurity such as debranching, leaf, carpopodiums.Acrid in the mouth, hardship, hot in nature; Slightly poisonous.Return liver, spleen, stomach, kidney channel.The function dispersing cold for relieving pain, stopping nausea and vomiting by lowering the adverse flow of QI, supporing yang antidiarrheal.Be used for headache due to JUE YIN disorder, colic of cold type stomachache, the disturbance of lower legs due to pathogenic cold and dampness, dysmenorrhea, abdominal pain during menstruation, abdominal distention, vomiting acid regurgitation, Diarrhoea, external treatment aphtha; Hypertension.
Flos Caryophylli
This product is the dry flower of plant clove of myrtaceae Eugenia caryophyllata Thunb..When alabastrum turns red by green, pluck, dry.Acrid in the mouth, warm in nature.Return spleen, stomach, lung, kidney channel.The function warming middle-JIAO to send down the adverse QI, reinforcing the kidney and supporting YANG.Be used for Deficiency and coldness of spleen and stomach, singultus vomiting, lack of appetite and vomiting, trusted subordinate's cold type of pain, impotence due to deficiency of the kidney.
The Radix Aucklandiae
This product is the dry root of feverfew Radix Aucklandiae Aucklandia lappa Decne..Autumn, two seasons of winter excavate, and remove silt and fibrous root, cutting, and large again vertical profile becomes lobe, hits rough bark after the drying.The Radix Aucklandiae is the common name of feverfew Saussurea lappa Clarke and Radix Vladimiriae.Saussurea lappa Clarke (formal name used at school: Saussurea costus), have another name called Radix Aucklandiae (Radix Vladimiriae) or Radix Aristolochiae, belong to the Compositae Genus Saussurea.Radix Vladimiriae (formal name used at school: Dolomiaea souliei) be the plant of Compositae Dolomiaea.Acrid in the mouth, hardship, warm in nature.Return spleen, stomach, large intestine, three warmers, gallbladder meridian.The function promoting the circulation of QI to relieve pain, strengthening the spleen to promote digestion.Be used for breast gastral cavity distending pain, heavy behind the dysentery, food stagnation does not disappear, anorexia.The real intestinal antidiarrheal of Radix Aucklandiae (roasted).Be used for having loose bowels stomachache.
Cortex Cinnamomi
This product is the dry bark of canella Cortex Cinnamomi Cinnamomum cassia Presl.More than stripping autumn, dry in the shade.Acrid in the mouth, sweet, extremely hot in nature.Return kidney, spleen, the heart, Liver Channel.It is supporing yang that function is mended fire, guiding fire to origin, dispersing cold for relieving pain, promoting the flow of QI-blood by warming the meridian.Be used for the sexual impotence cold womb, chills and pain of the waist and kness is suffered from a deficiency of the kidney and is done to breathe heavily, upward floating of YANG in deficiency condition, and dizzy conjunctival congestion, trusted subordinate's cold type of pain, deficiency and coldness is vomited and diarrhoea, colic of cold type stomachache, dysmenorrhea amenorrhea.
Rhizoma Atractylodis
This product is the dry rhizome of feverfew Atractylodes lancea (Thunb.) DC. Atractylodes lancea (Thunb.) DC. or Atractylis chinensis Atractylodes chinensis (DC.) Koidz..Spring, Qiu Erji excavate, and remove silt, dry, and hit fibrous root.Acrid in the mouth, hardship, warm in nature.Return spleen, stomach, Liver Channel.Function is drying damp and strengthening spleen, and expelling wind and cold makes eye bright.Be used for retention of dampness in middle-JIAO, distension and fullness in the abdomen is had loose bowels, edema, and the beriberi flaccidity is preesed, rheumatic arthralgia, anemofrigid cold, nyctalopia, eyes dusk is puckery.
The present invention finds out in the understanding to the Functional Abdominal Pain in Children basic pathogenesis.The basic pathogenesis of Functional Abdominal Pain in Children is: the retardance of condensing makes the breast food stagnate dysfunction of the spleen in transportation. stomach-QI being unable to descend normally, disorder of QI movement, stagnation of QI and blood may bring about pain.Fructus Evodiae dispersing cold for relieving pain of the present invention; The Flos Caryophylli warming middle-JIAO to send down the adverse QI, reinforcing the kidney and supporting YANG; Radix Aucklandiae promoting the circulation of QI to relieve pain, strengthening the spleen to promote digestion; The Cortex Cinnamomi dispersing cold for relieving pain, promoting the flow of QI-blood by warming the meridian; Rhizoma Atractylodis are drying damp and strengthening spleen, expelling wind and cold; The collocation of all medicines, play altogether spleen reinforcing and in, invigorating the spleen and regulating the stomach, the effect of relieving spasm to stop pain.The present invention arranges in pairs or groups rationally, adopts external application for curing, and Therapeutic Method is easy, and the property of medicine is steady, and effect cooperates the acupuncture point to massage and can obtain more preferably effect comprehensively.
Clinical test results such as embodiment 7 and embodiment 8 shows that Chinese medicine of the present invention has preferably effect by the external application for curing Functional Abdominal Pain in Children, and effective percentage reaches 94.64%; And execute in the process of controlling clinical, have no toxic and side effects, safe and reliable.
Chinese medicine provided by the invention has overcome the defective of prior art, has outstanding substantive distinguishing features and progressive significantly with respect to prior art.
The specific embodiment
Embodiment 1
Fructus Evodiae 100g Flos Caryophylli 200g Radix Aucklandiae 100g
Cortex Cinnamomi 100g Rhizoma Atractylodis 200g
Get whole 5 flavor medical materials, the volume by volume concentration that adds 700g is 40% alcohol dipping 12 hours, then be that 40% ethanol carries out percolation with the speed that per minute accounts for raw material gross weight 0.2% with volume by volume concentration, collect the percolate of 3500g, Recycled ethanol, be evaporated to 700g, filter, obtain active component.
Embodiment 2
Fructus Evodiae 500g Flos Caryophylli 300g Radix Aucklandiae 500g
Cortex Cinnamomi 300g Rhizoma Atractylodis 200g
Get whole 5 flavor medical materials, the volume by volume concentration that adds 3600g is 60% alcohol dipping 48 hours, then be that 60% ethanol carries out percolation with the speed that per minute accounts for raw material gross weight 0.6% with volume by volume concentration, collect the percolate of 18000g, Recycled ethanol, be evaporated to 3600g, filter, obtain active component.
With active component and an amount of antioxidant, propellant mix homogeneously, namely get aerosol of the present invention.
Embodiment 3
Fructus Evodiae 200g Flos Caryophylli 200g Radix Aucklandiae 300g
Cortex Cinnamomi 300g Rhizoma Atractylodis 200g
Get whole 5 flavor medical materials, at 50-60 ℃ of cold drying 48 h, pulverize and cross No. 7 sieve after mixing, low temperature interstitial sterilization treatment 48 h, packing is for subsequent use, namely gets powder agent of the present invention.
Embodiment 4
Fructus Evodiae 300g Flos Caryophylli 300g Radix Aucklandiae 300g
Cortex Cinnamomi 300g Rhizoma Atractylodis 300g
Get whole 5 flavor medical materials, the volume by volume concentration that adds 2250g is 56% alcohol dipping 24 hours, then be that 56% ethanol carries out percolation with the speed that per minute accounts for raw material gross weight 0.4% with volume by volume concentration, collect the percolate of 12000g, Recycled ethanol, be evaporated to 2500g, filter, obtain active component.
Relative density was 1.21 extractum when active component was concentrated into 80 ℃, cooperated with an amount of water-soluble base, stirred, and namely got ointment of the present invention.
Embodiment 5
Fructus Evodiae 100g Flos Caryophylli 500g Radix Aucklandiae 100g
Cortex Cinnamomi 500g Rhizoma Atractylodis 100g
Get whole 5 flavor medical materials, the volume by volume concentration that adds 2210g is 53% alcohol dipping 36 hours, then be that 56% ethanol carries out percolation with the speed that per minute accounts for raw material gross weight 0.4% with volume by volume concentration, collect the percolate of 11700g, Recycled ethanol, be evaporated to 1690g, filter, obtain active component.
Active component adds the adjuvants such as an amount of adhesive, wetting agent, filler, stirs, and coats on the back lining materials, namely gets gel rubber plaster unguentum of the present invention.
Embodiment 6
Fructus Evodiae 400g Flos Caryophylli 500g Radix Aucklandiae 100g
Cortex Cinnamomi 200g Rhizoma Atractylodis 400g
Get whole 5 flavor medical materials, the volume by volume concentration that adds 1920g is 55% alcohol dipping 18 hours, is that 58% ethanol carries out percolation with the speed that per minute accounts for raw material total weight parts 0.3% with volume by volume concentration then, collect the percolate of 11200g, stir, filter, namely get tincture of the present invention.
Embodiment 7
1, case is selected: the patient age scope is between between 3-7 year, and the course of disease time is more than 2 months.
2, diagnostic criteria
With reference to Applied Clinical Pediatrics magazine " child's functional gastrointestinal disorder: Rome III criteria for classification " in 2008.Must comprise following each bar:
(1) ictal or persistence stomachache;
(2) do not reach the standard of other functional gastrointestinal disorders (FGID);
(3) can not explain the evidence of inflammatory, dissection, Developmental and Metabolic Disorder or the tumor aspect of patient's symptom.
Can at least 1 time/week, at least ability diagnosis in lasting 2 months.
3, curative effect determinate standard:
Cure: stomachache disappears, and does not reaccess in 1 week:
Produce effects: the stomachache degree obviously alleviates, and seizure frequency reduces more than 75%, and the persistent period significantly shortens;
Effectively: the stomachache degree alleviates;
Invalid: stomachache and other symptoms are without improvement.
4, drug use method
Treatment group is coated on the gauze with the medicine of the embodiment of the invention 4, sticks in the refreshing SHENQUE acupoint of infant umbilicus with immobilization with adhesive tape, and every day 1 time, each medicine that is equivalent to crude drug amount 25g that uses, continuous 7 days was 1 course for the treatment of.But repetitive therapy 1-2 course for the treatment of.
Matched group: give oral Anisodamine 0.3～0.5 mg/(kgd), minute 3 clothes serve on drug withdrawal on the 3rd, and oral Yuanhuzhitong Dropping Pills and microbial ecological agent 1-2 grain serve on the treatment of 1 week simultaneously.
5, clinical treatment result
See Table 1
The contrast of table 1 clinical therapeutic efficacy
| Group | The example number | Cure | Produce effects | Effectively | Invalid | Total effective rate (%) |
| Treatment group | 56 | 46 | 4 | 3 | 3 | 94.64 |
| Matched group | 31 | 16 | 5 | 3 | 7 | 83.33 |
Embodiment 8
1, patient Wu * *, the women, 6 years old, the Liuzhou city, Guangxi province people, the course of disease 2 years, the main suit is because " Recurrent Abdominal Pain 2 years is sent out 2 days again and " examined.Through the present invention treatment, vomiting in the 1st day, stomachache alleviate, and vomiting in 2 days stops, and stomachache disappeared in 3 days, and 4 days spirit, appetite is as usual, recur in 1 week of adhering to providing follow-up care for a patient again.
2, patient Peng * *, the woman, 5 years old, people from Liuzhou, the course of disease 1 year is because " Recurrent Abdominal Pain more than 1 year is sent out 1 day again " examines.Treat the 2nd day sx↓ through the present invention, stomachache disappeared in the 5th day, followed up a case by regular visits to not again recurrence of symptom in 1 week of continual cure.
3, patient Liao * *, the woman, 7 years old, the Liuzhou city, Guangxi province people examined, treats 3 days symptoms through the present invention and obviously alleviate because of " Recurrent Abdominal Pain February, send out and increase the weight of 3 days " at course of disease February, returned to one's perfect health after treating for 1 week.
4, patient's beam * *, the male, 6 years old, the Liuzhou city, Guangxi province people examined because of " abdominal pain February, increased the weight of 1 day " in course of disease February, treats remission in 3 days through the present invention, in 1 week of continual cure, follows up a case by regular visits to symptom not more not repeatedly.
5, the patient yellow * *, the woman, 5 years old 10 months, the Liuzhou city, Guangxi province people examined because of " abdominal pain March, send out 1 day " in course of disease March again, treats remission in 3 days through the present invention, in 1 week of continual cure, follows up a case by regular visits to symptom not more not repeatedly.
Claims (6)
1. Chinese medicine for the treatment of Functional Abdominal Pain in Children is characterized in that it is to be prepared from by the raw material that comprises following weight portion:
Fructus Evodiae 10～50 Flos Caryophyllis 10～50 Radix Aucklandiae 10～50
Cortex Cinnamomi 10～50 Rhizoma Atractylodis 10～50.
2. the Chinese medicine for the treatment of Functional Abdominal Pain in Children as claimed in claim 1 is characterized in that it is to be prepared from by the raw material that comprises following weight portion:
Fructus Evodiae 20～40 Flos Caryophyllis 20～40 Radix Aucklandiae 20～40
Cortex Cinnamomi 20～40 Rhizoma Atractylodis 20～40.
3. the Chinese medicine for the treatment of Functional Abdominal Pain in Children as claimed in claim 2 is characterized in that it is to be prepared from by the raw material that comprises following weight portion:
Fructus Evodiae 30 Flos Caryophyllis 30 Radix Aucklandiae 30
Cortex Cinnamomi 30 Rhizoma Atractylodis 30.
4. the Chinese medicine for the treatment of Functional Abdominal Pain in Children as claimed in claim 1 is characterized in that its active component is prepared from by the following method:
Get whole 5 flavor medical materials, added the volume by volume concentration be equivalent to 1～2 times of this 5 flavor medical material gross weight and be 40%～60% alcohol dipping 12～48 hours, then be that 40%～60% ethanol carries out percolation with the speed that per minute accounts for raw material gross weight 0.2%～0.6% with volume by volume concentration, collection is equivalent to the percolate that this 5 flavor medical material gross weight 5-10 doubly measures, Recycled ethanol, be evaporated to 1～2 times that is equivalent to 5 flavor medical material gross weights, filter, obtain active component.
5. the Chinese medicine of Functional Abdominal Pain in Children is treated in treatment as claimed in claim 1, it is characterized in that its active component is prepared from by the following method:
Get whole 5 flavor medical materials, added the volume by volume concentration be equivalent to 1～2 times of this 5 flavor medical material gross weight and be 50%～56% alcohol dipping 24～36 hours, then be that 50%～56% ethanol carries out percolation with the speed that per minute accounts for raw material gross weight 0.3%～0.5% with volume by volume concentration, collection is equivalent to the percolate that this 5 flavor medical material gross weight 5-10 doubly measures, Recycled ethanol, be evaporated to 1～2 times that is equivalent to 5 flavor medical material gross weights, filter, obtain active component.
6. a Chinese medicine preparation for the treatment of Functional Abdominal Pain in Children comprises the Chinese medicine of each treatment Functional Abdominal Pain in Children in the claim 1～5 and pharmaceutically acceptable carrier.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105126007A (en) * | 2015-10-13 | 2015-12-09 | 广州中医药大学 | Patch for treating infantile diarrhea |
| CN105169205A (en) * | 2015-10-13 | 2015-12-23 | 广州中医药大学 | Navel sticker for treating infantile diarrhea |
| CN105456457A (en) * | 2016-01-08 | 2016-04-06 | 牙述东 | Medicine for treating colic of horses |
| CN107823612A (en) * | 2017-12-05 | 2018-03-23 | 广州中医药大学第附属医院 | A kind of children transport spleen application and dissipate and its apply |
| CN112618633A (en) * | 2021-01-18 | 2021-04-09 | 广州中医药大学第一附属医院 | Traditional Chinese medicine composition and application thereof |
-
2012
- 2012-12-26 CN CN201210573485.4A patent/CN103054990B/en not_active Expired - Fee Related
Non-Patent Citations (1)
| Title |
|---|
| 张俊庭: "《中国中医特治新法大全》", 31 December 1996 * |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105126007A (en) * | 2015-10-13 | 2015-12-09 | 广州中医药大学 | Patch for treating infantile diarrhea |
| CN105169205A (en) * | 2015-10-13 | 2015-12-23 | 广州中医药大学 | Navel sticker for treating infantile diarrhea |
| CN105169205B (en) * | 2015-10-13 | 2018-12-25 | 广州中医药大学 | A kind of navel paster for treating baby diarrhea |
| CN105126007B (en) * | 2015-10-13 | 2018-12-25 | 广州中医药大学 | A kind of patch for treating baby diarrhea |
| CN105456457A (en) * | 2016-01-08 | 2016-04-06 | 牙述东 | Medicine for treating colic of horses |
| CN107823612A (en) * | 2017-12-05 | 2018-03-23 | 广州中医药大学第附属医院 | A kind of children transport spleen application and dissipate and its apply |
| CN112618633A (en) * | 2021-01-18 | 2021-04-09 | 广州中医药大学第一附属医院 | Traditional Chinese medicine composition and application thereof |
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| CN103054990B (en) | 2014-11-05 |
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