CN101342271B - Traditional Chinese medicine for treating qi-blood deficiency caused by tumour chemotherapy and preparation method thereof - Google Patents

Traditional Chinese medicine for treating qi-blood deficiency caused by tumour chemotherapy and preparation method thereof Download PDF

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CN101342271B
CN101342271B CN200810212246XA CN200810212246A CN101342271B CN 101342271 B CN101342271 B CN 101342271B CN 200810212246X A CN200810212246X A CN 200810212246XA CN 200810212246 A CN200810212246 A CN 200810212246A CN 101342271 B CN101342271 B CN 101342271B
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rhizoma
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CN101342271A (en
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张立莲
杜彦秋
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Abstract

The present invention discloses a traditional Chinese medicine which is used for treating qi-blood deficiency caused by chemotherapy of tumor, and a preparation method thereof. The ingredients of the traditional Chinese medicine have the following weight portions: 20 to 40 portions of radix astragali, 20 to 40 portions of angelica, 10 to 20 portions of codonopsis pilosula, 10 to 20 portions of Chinese wolfberry, 10 to 20 portions of giant knotweed, 10 to 20 portions of herba centellae, 10 to 20 portions of hemlock parsley, 10 to 20 portions of tuckahoe, 10 to 20 portions of cinnamon, 10 to 20 portions of Astraolylis lancea formalyrata, 10 to 20 portions of forsythia, 10 to 20 portions of radix sileris, 10 to 20 portions of prepared radix rehmanniae, 10 to 20 portions of radix-polygoni multiflori, 10 to 20 portions of ass-skin glue, and 10 to 20 portions of licorice. The toxicity test and the clinical test have proven that the medicine has excellent anti-tumor effects, capability of preventing the pains caused by cancer, less toxic side effects, and mild medicinal effects. The preparation method has the advantages of simple operation, reasonable technology, stable and controllable quality, suitability for industrial production, and less loss of medicine ingredients.

Description

The Chinese medicine and the preparation method of the QI and blood deficiency that the treatment chemotherapy of tumors causes
Technical field
The present invention relates to a kind of medicine of assisting chemotherapy of tumors, particularly a kind of is the Chinese medicine that is used to cure the QI and blood deficiency that chemotherapy of tumors causes of feedstock production with the Chinese herbal medicine, and this preparation method of Chinese medicine.
Background technology
Tumor is one of commonly encountered diseases of harm humans health.It is about 7,000,000 that at present the world dies from the malignant tumor number every year, the annual about 1,600,000 New Development tumor patients of China, and 105 die ten thousand deaths in this inducement.Be first of various diseases death in the city, and have and increase trend year by year.Died from malignant tumor person and reach 8,400,000 people in the whole world more than 50 hundred million populations in 2007, new cases are 1,180 ten thousand examples, and now the trouble number is 2,860 ten thousand, and numeral is also increasing year by year.From domestic situation, malignant tumor constituent ratio in the cause of the death rises to 17.9% by 12.6% in the period of nearly 20, and the number of the infected of the annual cancer of China is 2,000,000, and the cancer mortality number surpasses 1,500,000.In the conference of the 18th world anticancer disease alliance, the research report that World Health Organization (WHO) delivers shows, whole world cancer condition will be serious day by day, new patient's number will be increased to 1,500 ten thousand by present every year 1000 ten thousand in 15 years from now on, now suffer from routine number and will increase to 3,000 ten thousand, the number dead because of cancer also will increase to 1,000 ten thousand by annual more than 700 ten thousand.Therefore, national governments, research institution and drugmaker are paid much attention to tumor research and antitumor drug research for a long time always.
Generally acknowledge that in the world curative effect antitumor drug commonly used preferably has 50~60 kinds approximately, WHO announces that antineoplastic agent commonly used is 49 kinds, and China can produce wherein about 40 kinds, reaches more than 80%.The present market situation of antitumor medication is the gesture of " standing like the legs of a tripod " substantially: antineoplastic agent accounts for 45%, and immunostimulant and immunosuppressant respectively account for about 26%, and the endocrine therapy medicine market share is then very little.There are 4 kinds to be plant alkaloid and other crude drug in the best antitumor drug and sell at 10 kinds.In addition, data shows according to the relevent statistics, be the chemical synthetic drug except that a few antineoplastic agents such as mitoxantrone, hydroxyurea and cisplatin in the antineoplastic agent of listing China nineties in last century, a series of antineoplastic agents (containing the human immunity agent) of go on the market (or still in development stage) are the composition that extracts in the natural herbal.Therefore, a few years from now on China emerges large quantities of new type natural medicine series antineoplastic medicaments probably.The natural antitumor medicine probably became the leading role of China or world's antitumor drug in 10 years from now on.
The chemotherapy malignant tumor has basically formed a complete theoretical system since the application of nineteen forty-six chlormethine.But because most of chemicals poor selectivity, the physiological function to normal structure and internal organs after the medication has certain destruction, often causes chemotherapy treatment and a series of toxicities such as can not finish.Mainly show as: bone marrow depression; Digestive tract reaction; Immunologic hypofunction etc.
The method curative effect of the various control chemotherapy toxic side effects of modern medicine certainly at present: as blood transfusion, sharp blood liter, hemopoietic growth factor, ondansetron etc.But also there are many problems in these present methods, have inadequate blood source as blood transfusion, and paathogenic factor gets more and more and limits its use in the blood; Hemopoietic growth factor can promote that the leukaemia breeds, and suppress the cytotoxicity chemotherapeutics and bring out the acute leukemia cells apoptosis, and the bone marrow that can not solve chemotherapy damages outward, has dispute so hemopoietic growth factor used.Simultaneously, these drug mains will work from single angle, integrally-regulated poor effect; And cost an arm and a leg, clinical use is limited.
Chinese medicine preparation kind with regard to existing treatment chemotherapy of tumors is to be that principle is selected the medicine prescription with the strengthening the body resistance mostly, and curative effect is sure.Yet, clinical practice shows that many tumor patients itself have the existence of syndrome of blood stasis, after particularly having accepted chemotherapy, obviously increasing and increasing the weight of appears in patient's syndrome of blood stasis due to qi deficiency, show as the appearance of picture of the tongue and the objective disease of traditional Chinese medical science blood stasis, microcosmic detects high blood coagulation state and patient's cellular immune function and active the reduction, and is relevant with transfer with the recurrence of tumor middle and advanced stage.So only exist certain not enough from setting upright angle.
Summary of the invention
The present invention on the basis of traditional medicine in conjunction with clinical experience for many years, a kind of Chinese medicine preparation of the QI and blood deficiency that chemotherapy of tumors causes and manufacture method of this Chinese medicine thereof for the treatment of is provided, to overcome the problem that prior art exists, Chinese medicine determined curative effect of the present invention, effect is obvious, toxic and side effects is little, and effective dose is controlled easily, cheap medicine.
For solving the problems of the technologies described above, the invention provides a kind of Chinese medicine of curing the QI and blood deficiency that chemotherapy of tumors causes, the ratio of weight and number of various compositions is: 20~40 parts of the Radixs Astragali, 20~40 parts of Radix Angelicae Sinensis, 10~20 parts of Radix Codonopsis, 10~20 parts of Fructus Lyciis, 10~20 parts of Rhizoma Polygoni Cuspidati, 10~20 parts of Herba Centellaes, 10~20 parts of Rhizoma Chuanxiongs, 10~20 parts in Poria, 10~20 parts of Cortex Cinnamomis, 10~20 parts of the Rhizoma Atractylodis Macrocephalaes, 10~20 parts of Fructus Forsythiaes, 10~20 parts of Radix Saposhnikoviaes, 10~20 parts in Radix Rehmanniae Preparata, 10~20 parts of Radix Polygoni Multiflori, 10~20 parts in Colla Corii Asini, 10~20 parts in Radix Glycyrrhizae.
The Chinese medicine of the QI and blood deficiency that described treatment chemotherapy of tumors causes, the ratio of weight and number of various compositions can also be 30~40 parts of the Radixs Astragali, 30~40 parts of Radix Angelicae Sinensis, 10~20 parts of Radix Codonopsis, 10~15 parts of Fructus Lyciis, 10~15 parts of Rhizoma Polygoni Cuspidati, 10~15 parts of Herba Centellaes, 10~15 parts of Rhizoma Chuanxiongs, 10~15 parts in Poria, 10~15 parts of Cortex Cinnamomis, 10~15 parts of the Rhizoma Atractylodis Macrocephalaes, 10~15 parts of Fructus Forsythiaes, 10~15 parts of Radix Saposhnikoviaes, 10~15 parts in Radix Rehmanniae Preparata, 10~15 parts of Radix Polygoni Multiflori, 10~15 parts in Colla Corii Asini, 10~15 parts in Radix Glycyrrhizae.
The Chinese medicine of the QI and blood deficiency that described treatment chemotherapy of tumors causes, the ratio of weight and number of various compositions also can be 20~30 parts of the Radixs Astragali, 20~30 parts of Radix Angelicae Sinensis, 15~20 parts of Radix Codonopsis, 15~20 parts of Fructus Lyciis, 15~20 parts of Rhizoma Polygoni Cuspidati, 15~20 parts of Herba Centellaes, 15~20 parts of Rhizoma Chuanxiongs, 15~20 parts in Poria, 15~20 parts of Cortex Cinnamomis, 15~20 parts of the Rhizoma Atractylodis Macrocephalaes, 15~20 parts of Fructus Forsythiaes, 15~20 parts of Radix Saposhnikoviaes, 15~20 parts in Radix Rehmanniae Preparata, 15~20 parts of Radix Polygoni Multiflori, 15~20 parts in Colla Corii Asini, 15~20 parts in Radix Glycyrrhizae.
The Chinese medicine of the QI and blood deficiency that described treatment chemotherapy of tumors causes, the ratio of weight and number of various compositions can be 30~40 parts of the Radixs Astragali, 30~40 parts of Radix Angelicae Sinensis, 10~15 parts of Radix Codonopsis, 10~15 parts of Fructus Lyciis, 15~20 parts of Rhizoma Polygoni Cuspidati, 15~20 parts of Herba Centellaes, 10~15 parts of Rhizoma Chuanxiongs, 10~15 parts in Poria, 10~15 parts of Cortex Cinnamomis, 10~15 parts of the Rhizoma Atractylodis Macrocephalaes, 10~15 parts of Fructus Forsythiaes, 10~15 parts of Radix Saposhnikoviaes, 10~15 parts in Radix Rehmanniae Preparata, 10~15 parts of Radix Polygoni Multiflori, 10~15 parts in Colla Corii Asini, 10~15 parts in Radix Glycyrrhizae again.
The Chinese medicine of the QI and blood deficiency that described treatment chemotherapy of tumors causes, the ratio of weight and number of various compositions can be 20~30 parts of the Radixs Astragali, 20~30 parts of Radix Angelicae Sinensis, 15~20 parts of Radix Codonopsis, 15~20 parts of Fructus Lyciis, 10~15 parts of Rhizoma Polygoni Cuspidati, 10~15 parts of Herba Centellaes, 10~15 parts of Rhizoma Chuanxiongs, 10~15 parts in Poria, 10~15 parts of Cortex Cinnamomis, 10~15 parts of the Rhizoma Atractylodis Macrocephalaes, 10~15 parts of Fructus Forsythiaes, 10~20 parts of Radix Saposhnikoviaes, 10~20 parts in Radix Rehmanniae Preparata, 10~20 parts of Radix Polygoni Multiflori, 10~20 parts in Colla Corii Asini, 10~15 parts in Radix Glycyrrhizae again.
Described form of Chinese drug can be decoction, powder, honey refining pill, hydration pill, tablet, capsule, oral liquid, granule or syrup.
For solving the problems of the technologies described above, the present invention provides a kind of preparation method of Chinese medicine of curing the QI and blood deficiency that chemotherapy of tumors causes again, and the preparation of described drug powder may further comprise the steps:
With described raw material water brush, wash clean, pull out and dry;
Radix Codonopsis, Rhizoma Chuanxiong, Poria, Cortex Cinnamomi, Radix Rehmanniae Preparata are put into the little fire of marmite respectively fried 5~10 minutes, respectively it is ground into smalls, sieve with pulverizer;
The Radix Astragali after will drying, Radix Angelicae Sinensis, Radix Polygoni Multiflori, Colla Corii Asini, Radix Glycyrrhizae are sent into respectively and are cut into flakelet in the microtome, again the raw material of above-mentioned processing and all the other raw materials are sent into pulverizer and are ground into smalls, sieve.
The used sieve that sieves can be 90~110 orders.
The time of pulverizing in pulverizer can be 10~15 minutes.
Described method may further include the step that adopts ultraviolet radiation to carry out disinfection to mixed smalls.
Medicament of the present invention proves to have good antitumor action and end the cancer pain effect through toxicity test and clinical trial, toxic and side effects is very little, and the property of medicine is gentle.Chinese medicine of the present invention is many based on hyperactivity of toxic heat at cancer, has qi depression to blood stasis concurrently, and the characteristics of QI and blood deficiency, weakness of the spleen and stomach adopt regulating the flow of QI to dissipate blood stasis, strengthening vital QI to eliminate pathogenic factors, and the prescription strategy of reinforcement and elimination in combination has embodied the characteristic of the traditional Chinese medical science " determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs ".Prescription is formed from traditional Chinese medical science clinical practice, draws traditional Chinese medical science tradition and medication experience among the people, according to the chemotherapy of tumors clinical characters with adapt to syndrome and select the medicine prescription, reuses that the property of medicine is gentle, the medicine of tool benefiting action, and prescription has certain characteristic, and clinical treatment is definite.Preparation method provided by the invention is simple to operate, technology is reasonable, stable and controllable for quality, be suitable for suitability for industrialized production, the ingredient loss is few.
The specific embodiment
Technical scheme of the present invention be based on motherland's medical science to chemotherapy of tumors after the understanding and the Therapeutic Principle of toxicity, achieve with reference to modern pharmacological research, from motherland's medical treasure-house, filter out the natural plant of kidney tonifying spleen invigorating, inrigorating qi and promoting blood circulation, by the theory of Chinese medical science prescription, skim the cream off milk, make its performance improve human immunity state, control bone marrow depression, reduce digestive tract reaction, microcirculation improvement, collaborative chemotherapy improve curative effect, control tumor recurrence and transfer, prolong life cycle, alleviate the effect of life quality.The traditional Chinese medical science think tumor many because of eating and drinking without temperance, seven emotions (happiness, anger, melancholy, think of, compassion, probably, frightened) excessively, etc. factor cause the human body imbalance of YIN and YANG, the pyretic toxicity heap soil or fertilizer over and around the roots is stagnant, qi depression to blood stasis is held concurrently QI and blood deficiency and is caused.
" element is asked the logical deficiency and excess opinion of commenting " said: " the diaphragm plug closes exhausted, and obstructed up and down, then disease due to intense worry also." illustrated that dysphagic morbidity is relevant with sudden and violent melancholy.Zhu Danxi thinks that breast carcinoma (cancer) is that " melancholy anger is gloomy, and gather morning and evening, the temper resistance that disappears, transverse invasion of hyperactive liver-QI " institute causes, says in " raving small house collection proved recipe ": " lid five kinds of masses in the chest and abdomen person, because of the gas of anger, melancholy, think of seven emotions to hinder five hollow organs, meet biography and restrain and not all rightly forms disease also." illustrate because seven emotions excessively can influence the function of five hollow organs, make it loss, easily recruit the exopathogen invasion, also can make functional activity of QI being not smooth, venation is obstructed, and qi depression to blood stasis forms cancer.According to the cause of disease of tumor, many at tumor with hyperactivity of toxic heat, qi depression to blood stasis, deficiency of both QI and blood is main syndrome, with regulating the flow of QI to dissipate blood stasis, benefiting vital QI and blood is main and prescription, has embodied the characteristic of tcm treatment according to syndrome differentiation; Aspect the selecting for use of medicine, need not high strict product, and be principal agent with the gentle medicine of the property of medicine, embodied doctor's drug safety among the people, effectively " seen " to use characteristics in flat strange.
Take a broad view of full side, compatibility is rigorous, eliminating evil with set upright and execute, play the merit of regulating the flow of QI to dissipate blood stasis, benefiting vital QI and blood, function of spleen and stomach regulating altogether, so that the deficiency of both QI and blood that chemotherapy of tumors is caused is used is effective.
The present invention cures the Chinese medicine of the QI and blood deficiency that chemotherapy of tumors causes, the effect of each herbal medicine is: Radix Astragali tonifying Qi and lifting yang, holder skin ulcer granulation promoting; Be used for the replenishing vital QI with drugs of warm nature taste and granulation promoting is used for insufficiency of vital energy and blood, skin infection caves in, and bursts for a long time and does not hold back; Invigorating the spleen and benefiting QI, and the adjusting body's immunological function is arranged.
Radix Angelicae Sinensis is sweet, hot, temperature.Return liver, the heart, spleen channel.Enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.Be used for blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores." Treatise on Febrile Disease with Notes ": the arteries and veins person house of blood, all blood all belongs to the heart, all persons of promoting blood circulation must be first reinforcing the heart benefit blood, so Zhang Zhongjing control brothers faint cold, the thready pulse being about to disappear person, with the hardship temperature of Radix Angelicae Sinensis to help painstaking effort.Materia Medica of Decoction: Radix Angelicae Sinensis, few the moon of starting with, with its heart master blood also; It is lunar to go into foot, wraps up in blood also with its spleen; Go into the sufficient the moon of fainting, also with its blood stored in the liver.Head energy removing blood stasis, body can nourish blood, and the promoting the circulation of blood of tail energy is regardless of with the person, not as not making.If full usefulness all can be enriched blood at ginseng, stilbene; Lead a cow, Radix Et Rhizoma Rhei, all can removing blood stasis, assistant makes decides branch, with the person when knowing.From osmanthus, attached, Fructus Evodiae heat then; Then cold from Radix Et Rhizoma Rhei, Natrii Sulfas.Only the wine Radix Angelicae Sinensis (steamed) is controlled headache again, all belongs to wood with its all headache, thus with blood medicine master it.
The Radix Codonopsis benefiting QI for strengthening the superficies, strengthening superficial resistance to stop perspiration, the invigorating the spleen and replenishing QI benefit is supported the day after tomorrow, modern pharmacological research confirms that body nonspecific immunity humoral immunization, cellular immunization are all had tangible regulating action, promote the reticuloendothelial system phagocytic effect, improve immune status, increase the resistance of pernicious stimulation to external world.
The Fructus Lycii the kidney invigorating and essence nourishing, nourishing the liver to improve visual acuity, blood-enriching tranquillizing, promoting the production of body fluid to quench thirst, nourishing the lung to arrest cough.The treating the liver kidney yin is lost, soreness of the waist and knees, and dizziness, dizzy, the many tears of blurred vision, cough due to consumptive disease is quenched one's thirst, seminal emission." the smart various symptoms and signs of deficiency of energy tonification, easily color bleaches, and makes eye bright, and calms the nerves " property of medicine opinion "." " Treatise on Dietetic Therapy " " hard muscle is anti-old, removes wind, and tonification muscles and bones can benefit be gone into, and removes asthenia." " detailed outline ": " nourishing kidney, lung moistening make eye bright." " book on Chinese herbal medicine is stated ": " treat the liver-wind blood deficiency, the confused nebula of eye red sufferings.It is dizzy to control apoplexy, and asthenia is allly seen blood disorder, cough blood, flaccidity, faint, contraction, the miasma that disappears is hindered dryly, passes out semen reddish and whitish turbid urine, beriberi, the arthroncus of knee.”
Rhizoma Polygoni Cuspidati, little hardship are slightly cold.Return liver, gallbladder, lung meridian.Expelling wind and removing dampness, dissipating blood stasis analgesic therapy, relieving cough and resolving phlegm.Be used for arthralgia, jaundice due to damp-heat, amenorrhea, lump in the abdomen, burn due to hot liquid or fire, injury from falling down, carbuncle sore tumefacting virus, cough with copious phlegm.Modern medicine study shows that Rhizoma Polygoni Cuspidati has antitumor action, and the anthraquinone analog compound in the Rhizoma Polygoni Cuspidati can suppress people's its effect of children's grain leukocyte (HL-60) cell early.Mechanism mainly is suppress cell DNA and RNA synthetic the strongest with the cytotoxicity of emodin, under 100umol/L (about 40 μ g/ml) concentration precursor [3H-Me] dThd of DNA is mixed inhibitory action to be in proper order: emodin, physcione-8-O-D-glycoside〉physcione〉emodin-8-O-D-glycoside〉chrysophanic acid〉Polydatin.RNA precursor [5.3H] cyd is mixed inhibitory action want littler, it is in proper order: emodin〉physcione〉physcione-8-O-D-glycoside, Polydatin.Oral Rhizoma Polygoni Cuspidati decoct 10 days is 35.3% to the tumour inhibiting rate of mice ehrlich carcinoma, and can prolongs the animals survived time.Emodin to the suppression ratio of 7 tumor strains such as murine sarcoma, mice hepatoma, mouse breast cancer, mice ehrlich carcinoma, mouse lymph sarcoma, murine melanoma and rat watt gram cancer all more than 30%." book on Chinese herbal medicine is stated ": the curing mainly of Rhizoma Polygoni Cuspidati, its promoting the circulation of blood like with the Radix Carpesii class, its treat wind like with the Semen Vaccariae class, the former worthies calls its expelling summer-heat poison more, is former in to remove stagnation of pathogenic heat from blood biochemistry then, the blood of the moon wind dirty and the sufficient the moon of fainting is dirty so hands is fainted, it is controlled as rousing and answers small wooden raft also.Side's book is same as the flavor of all heat clearing away in order to treat the convulsion patient, for cutting ear, so demonstrate,proves use also bright in him with its function, what? side's book is in order to control pouring, and promptly Dan Xi treats the injured pouring of old man's QI and blood, also thinks key medicine, uses in tonic.Call the person of diminishing of empty people's clothes, parallel with tonic, it so that.
Herba Centellae hardship, suffering, cold.Return the liver,spleen,kidney warp.Clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling.Be used for jaundice due to damp-heat, heatstroke diarrhoea, sand Stranguria stranguria with blood, carbuncle sore tumefacting virus, injury from falling down.
The Rhizoma Chuanxiong suffering, temperature.Return liver, gallbladder, pericardium channel.Blood-activating and qi-promoting, wind-expelling pain-stopping.Control air-cooled headache and revolve dizzyly, the hypochondriac pain abdomen is painful, arthralgia due to cold clonic spasm of the muscle, amenorrhea, difficult labour, postpartum stagnation piece pain, ulcer sores.Be used for menoxenia, amenorrhea dysmenorrhea, abdominal mass stomachache, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia." not Lu ": " remove in the brain cold movingly, urticaria goes on the face, the order lacrimation, profuse nasal discharge and spittle, before we notice it as liquor-saturated, all cold gas, the hard pain of trusted subordinate, attacked by pestiferous factors, the soldier is anxious to swell and ache, side of body wind pain, warming middle-JIAO endogenous cold." " property of medicine opinion ": " controls waist foot weakness, hemiplegia, and main afterbirth does not go out, and controls cold type of pain in the abdomen." " Japan hanako materia medica ": " controls a wind cutting, all gas, and all strains, all blood are mended five kinds of over strain, and strengthening bone and muscle is transferred many arteries and veins, and broken crux stagnated blood is supported fresh blood, puts on flesh, and serious epistaxis is spitted blood and hematuria, hemorrhoid complicated by anal fistula, brain carbuncle carbuncle on the back, the scrofula wart is superfluous, skin ulcer scabies, and evacuation of pus repercussive blood.″
Poria is sweet, flat, light, the function of have promoting diuresis to eliminate damp pathogen, spleen invigorating, calming the nerves.Modern medicine study shows that Poria has antitumor action.Pachyman has inhibitory action to murine sarcoma, and its effect is relevant with thymus, can activate local complement, has active anticancer in vivo, and can promote the immunologic function of human body; Contained pachyman can reach 96.88% to the inhibition efficient of sarcoma S-180.Preserved material has diuresis to normal rabbit as lumbar injection; Ether or ethanol extraction can make isolated frog heart shrink reinforcement, to tame rabbit blood glucose rising are then reduced.The Poria decoct has sedation to mice.
The Cortex Cinnamomi extremely hot in nature, acrid in the mouth, sweet.It is supporing yang to mend fire, let the fire back to its origin, dispersing cold for relieving pain, promoting blood circulation to restore menstrual flow.Be used for sexual impotence, cold womb, trusted subordinate's cold type of pain, deficiency and coldness vomiting and diarrhoea, amenorrhea, dysmenorrhea, warming the meridian and promoting blood circulation.Supplement to the Herbal: osmanthus, male osmanthus, Cortex Cinnamomi, gone up trichroismly, and be both a thing.By Guilin, Gui Ling, because of running after fame in osmanthus, the present give birth to, not from this prefecture.From sea, border on the south the mountain range, cassia tree is arranged to the greatest extent, only willow, Xiangzhou are maximum.Flavor is promptly hot strong, the thick again heavily fortified point of skin, and thick person must be tender, and Bao Zhebi is old.With Lao Bao person is of the same colour, is of the same colour with thick tender person, tender promptly hot fragrant, the tube volume again of holding concurrently; Always must be lightly seasoned, natural plate is thin.Plate approaches the person, promptly male osmanthus also, name is here with the eldest child; Tube volume person, promptly osmanthus also, with tender and easy volume.Ancient prescription has an osmanthus, and word is like word, descendant's mistake and book it, practise and become social custom, pass as for book, also multiple because of following.Cortex Cinnamomi promptly is to eliminate first mistake on the skin, get its near in, the Xin Eryou flavor.
Rhizoma Atractylodis Macrocephalae hardship, sweet, salty, cold has the function of heat clearing away, detoxifcation, yin nourishing.The Rhizoma Atractylodis Macrocephalae has invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive effect.Be used for insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement." medicine origin " record: " the dry and middle QI invigorating of dehumidifying benefit, warming middle-JIAO removes the taste being attacked by dampness, removes gastric heat, and strong taste advance diet, quench the thirst, and are antiabortive.”
The Fructus Forsythiae hardship is slightly cold.Return lung, the heart, small intestine meridian.Heat-clearing and toxic substances removing, dispersing swelling and dissipating binds.Be used for carbuncle, scrofula, acute mastitis, erysipelas, anemopyretic cold, epidemic febrile disease is from the beginning of, warm joining the army, the hyperpyrexia excessive thirst, coma is sent out speckle, the pyretic stranguria urine retention.The medicinal part of Fructus Forsythiae mainly is a fruit.Its shell, i.e. " sticking up " in " antelope sticks up detoxifying pills ".Contain forsythol, coumarin, oleanolic acid, Saponin, Citrin etc.Have effects such as heat clearing away, detoxifcation, eliminating stagnation evacuation of pus.Cure mainly warm, skin infection, scrofula, erysipelas, class's rash, influenza.
Radix Saposhnikoviae suffering, sweet, temperature.Return bladder, liver, spleen channel.Inducing diaphoresis to dispel wind wins and wets, relieving convulsion.Be used for headache due to common cold, rheumatic arthralgia, rubella pruritus, tetanus." not Lu ": hypochondriac pain, side of body public attention face goes, and the extremity contraction is anxious, convulsion in the word milk gold skin ulcer." Japan hanako materia medica ": wind as controlling 36, all labor of man are bad, and the invigorating middle warmer benefit is refreshing, blepharitis marginalis, arresting lacrimation and paralysis are slow, tonneau the five internal organs GUAN-pulse, five kinds of strain and seven kinds of impairment, thin damage night sweat, vexed body weight, energy tranquilizing the mind, even gaseous pulse." pearl sac ": body: go windward, the tip: go leeward." medicine class on the analogy of natural things ": it is general to control wind.Eliminating the pathogens from the lung is real, and the gas that stagnates among the head that looses removes part of the body cavity above the diaphragm housing the heart and lungs ailment said due to cold or exposure.
The Radix Rehmanniae Preparata sweet in the mouth, slightly warm in nature.Return liver, kidney channel.Has the YIN nourishing of enriching blood effect.Be used for blood deficiency and yellow complexion, dizzy, palpitation and insomnia, menoxenia, diseases such as metrorrhagia.Can be used for deficiency of kidney yin hectic fever hectic fever due to YIN-deficiency, night sweat, pass out semen, quench one's thirst etc.; The vital essence replenishing and marrow benifiting effect is used for the Liver and kidney essence and blood and loses empty soreness of the waist and knees, vertigo and tinnitus, early whitening of beard and hair etc.
Radix Polygoni Multiflori hardship, sweet, puckery, temperature.Return liver, the heart, kidney channel.Detoxifcation, eliminating carbuncle, loosening bowel to relieve constipation.Be used for the scrofula carbuncle sore, rubella pruritus, dryness of the intestine constipation; Hyperlipidemia.Modern medicine study shows that Radix Polygoni Multiflori has the function of enhance immunity.The Aged Mice spleen that Radix Polygoni Multiflori causes meticortelone and cyclophosphamide, the thymus inhibition changes that obvious antagonism is arranged, and the phagocytic rate of splenic macrophage and phagocytic index are obviously improved.The Radix Polygoni Multiflori ethanol extract of feeding can obviously improve the injury repairing ability of senile rat periphery lymphocyte DNA.Mouse gavaging Radix Polygoni Multiflori Preparata 6g/kg, successive administration 7 days can obviously improve the phagocytic activity of peritoneal macrophage, and the phagocytic index that meticortelone is caused descends, and tangible antagonism is arranged.Radix Polygoni Multiflori decocting ethanol extract all has potentiation to mouse T lymphocyte and bone-marrow-derived lymphocyte immunologic function, and the former effect is more remarkable.Radix Polygoni Multiflori extract 25-100mg/kg, lumbar injection, successive administration 3 days can significantly improve normal mouse by inductive thymus of ConA and splenic T lymphproliferation response; Subcutaneous injection 5-100g/kg, continuous 3 days, can obviously increase normal mouse spleen antibody forming cell number, the most remarkable with the effect of 50g/kg group.
Colla Corii Asini is sweet, and is flat." herbal classic ": " sweet in the mouth is flat." " not Lu ": " tepor, nontoxic." " medicine origin ": " " curing mainly secret formula " cloud, property is flat, and is lightly seasoned." go into lung, liver, kidney channel.Nourishing YIN and supplementing blood, antiabortive.Control blood deficiency, cough due to consumptive disease is spitted blood, and epistaxis, has blood in stool menoxenia, metrorrhagia, vaginal bleeding during pregnancy." herbal classic ": " collapse the extremely voluminous symptoms like malaria of labor, waist stomachache, painful limbs, woman's hematochezia in the main trusted subordinate.Antiabortive.Obey QI invigorating for a long time." " not Lu ": " husband's lower abdominal pain, asthenia weakness and emaciation, cloudy QI-insufficiency, foot acid unable to stand for a long time, nourishing the liver gas." " property of medicine opinion ": " main hard muscles and bones, the QI invigorating dysentery relieving." " a thousand pieces of gold dietetic therapy ": " controls strong wind.″
Radix Glycyrrhizae is sweet, and is flat.GUIXIN, lung, spleen, stomach warp.Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.Be used for weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, the anxious pain of extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.The Radix Glycyrrhizae nature and flavor are sweet, and are flat.The popular feeling, lung, spleen, stomach warp.Being used as medicine can eliminating fire and detoxication, the lung moistening expelling phlegm for arresting cough, and QI invigorating invigorating middle warmer, relieving spasm to stop pain, the mitigation property of medicine are used for the treatment of deficiency of heart-QI, severe palpitation, irregularly intermittent and regularly intermittent pulse, weakness of the spleen and stomach, insufficiency of vital energy and blood, lassitude, and disease such as the anxious pain of spasm in the abdomen.The property of medicine of Radix Glycyrrhizae relaxes, and can rise, can fall, and can be used with various kinds of drug such as tonic, cathartic, cold medicine, warm medicine, the medicine of a cold natures, and the effect of the mediation property of medicine is arranged.Western modern medicine haircut is existing, and the Radix Glycyrrhizae agent has the function of antiinflammatory and the reflection of resistance attitude, therefore in doctor trained in Western medicine clinically mainly as demulcent.Relieving cough eliminates the phlegm, treatment pharyngalgia laryngitis; Radix Glycyrrhizae or enoxolone have the effect of desoxycortone class, and chronic adrenocortical hypofunction is had good efficacy; Glycyrrhiza preparation can promote stomach mucus to form and secretion, prolongs the epithelial cell life-span, and anti-inflammatory activity is arranged, and is usually used in the treatment of chronic ulcer and duodenal ulcer; The flavone of Radix Glycyrrhizae has antiinflammatory, spasmolytic and antiacid effect.
Medicine of the present invention and tumor chemotherapeutic drug combined effect can strengthen patient's immunologic function and anti-cancer ability, regulate patient's negative and positive, zang-fu disharmony; Chemotherapy effect anticancer, that kill tumor cell is stronger, but bigger toxic and side effects is arranged.Chinese medicine of the present invention in kidney tonifying spleen invigorating, the body resistance strengthening and constitution consolidating, raising immunity, blood-activating and stasis-removing in addition; Clinical practice shows, many tumor patients have the existence of syndrome of blood stasis, after particularly early accepting chemotherapy, patient's syndrome of blood stasis due to qi deficiency occurrence rate obviously improves and increases the weight of, show as the appearance of picture of the tongue and the objective disease of the traditional Chinese medical science, the microcosmic aspect detects high blood coagulation state, simultaneously, and the syndrome of blood stasis of tumor patient and the recurrence of tumor and shift closely related.Chinese medicine of the present invention can microcirculation improvement, change hypercoagulability, promote blood circulation, strengthens the groundwater increment of tumor tissues blood and the oxygen content of diseased region cancerous cell, reduces anoxic cell, improves the sensitivity of chemotherapy.
By following effect experiment beneficial effect of the present invention is described, tests used medicine and be:
Experiment Chinese medicine I: Radix Astragali 40g, Radix Angelicae Sinensis 30g, Radix Codonopsis 10g, Fructus Lycii 10g, Rhizoma Polygoni Cuspidati 10g, Herba Centellae 10g, Rhizoma Chuanxiong 10g, Poria 10g, Cortex Cinnamomi 10g, Rhizoma Atractylodis Macrocephalae 10g, Fructus Forsythiae 10g, Radix Saposhnikoviae 10g, Radix Rehmanniae Preparata 10g, Radix Polygoni Multiflori 10g, Colla Corii Asini 10g, Radix Glycyrrhizae 10g.
Experiment Chinese medicine II: Radix Astragali 30g, Radix Angelicae Sinensis 20g, Radix Codonopsis 15g, Fructus Lycii 15g, Rhizoma Polygoni Cuspidati 15g, Herba Centellae 15g, Rhizoma Chuanxiong 15g, Poria 15g, Cortex Cinnamomi 15g, Rhizoma Atractylodis Macrocephalae 15g, Fructus Forsythiae 15g, Radix Saposhnikoviae 15g, Radix Rehmanniae Preparata 15g, Radix Polygoni Multiflori 15g, Colla Corii Asini 15g, Radix Glycyrrhizae 15g.
Experiment Chinese medicine III:g Radix Astragali 30g, Radix Angelicae Sinensis 30g, Radix Codonopsis 10g, Fructus Lycii 10g, Rhizoma Polygoni Cuspidati 15g, Herba Centellae 15g, Rhizoma Chuanxiong 10g, Poria 10g, Cortex Cinnamomi 10g, Rhizoma Atractylodis Macrocephalae 10g, Fructus Forsythiae 10g, Radix Saposhnikoviae 10g, Radix Rehmanniae Preparata 10g, Radix Polygoni Multiflori 10g, Colla Corii Asini 10g, Radix Glycyrrhizae 10g.
The medicine that each group prepares according to following method respectively:
With aforementioned base materials water brush, wash clean, pull out and dry;
Radix Codonopsis, Rhizoma Chuanxiong, Poria, Cortex Cinnamomi, Radix Rehmanniae Preparata are put into the little fire of marmite respectively fried 5~10 minutes, respectively it is ground into smalls with pulverizer, with 100 purpose sieve;
The Radix Astragali after will drying, Radix Angelicae Sinensis, Radix Polygoni Multiflori, Colla Corii Asini, Radix Glycyrrhizae are sent into respectively and are cut into flakelet in the microtome, again raw material and all the other raw materials of above-mentioned processing are sent into pulverizer pulverizing 12 minutes, with 100 purpose sieve, carry out disinfection with ultraviolet radiation, medicine is divided into 200 parcel packed for standby use.
50 of ICR mices, male 20 ± 2 grams are divided into five groups at random:
Simple chemotherapy group, model control group, chemotherapy and Chinese medicine I treatment group, chemotherapy and Chinese medicine II treatment group, chemotherapy and Chinese medicine III treatment group.
Simple chemotherapy group: inoculate into S180 sarcoma animal model, chemotherapeutics is 10mg/ml cyclophosphamide (CTX), and dosage is 220mg/kg, lumbar injection, once a day, continuous 10 days;
Model control group: inoculate into S180 sarcoma animal model, irritate stomach with the 2ml normal saline every day, once a day, and continuous 10 days;
Chemotherapy and Chinese medicine I treatment group: will give mouse stomach behind the 1 parcel Chinese medicine I adding 1ml normal saline mixing, once a day, continuous 10 days;
Chemotherapy and Chinese medicine II treatment group: will give mouse stomach behind the 1 parcel Chinese medicine II adding 1ml normal saline mixing, once a day, continuous 10 days;
Chemotherapy and Chinese medicine III treatment group: will give mouse stomach behind the 1 parcel Chinese medicine III adding 1ml normal saline mixing, once a day, continuous 10 days.
Peripheral blood was got blood in mouse tail vein on the 6th day after as chemotherapy, measured WBC, HB, PLT.CFU-E (BFU-E) and the unicellular colony forming cell of grain (CFU-GM) are cultivated the 11 day mice and are taken off neck execution, and separate mouse femur in aseptic workbench the sterilization back, charges and attacks bone marrow with the IMDM culture fluid and become individual cells.After getting 2% leukocyte diluent 0.38ml and adding 20 μ l cell suspension mixings, drip counting chamber counting mononuclearcell.Cultivate with reference to the methylcellulose method, counted BFU-E and CFU-GM value in the 17 day.
The 6th day mice blood picture situation of change after the chemotherapy
Group WBC (* 109/c) N (%) L (%)
Treatment group I 22.17 ± 1.81 55.21 ± 2.36 47.63 ± 2.91
Treatment group II 21.89 ± 1.32 56.12 ± 2.18 48.14 ± 2.72
Treatment group III 22.05 ± 1.56 57.15 ± 2.13 47.77 ± 2.16
Chemotherapy group 18.98 ± 2.16 53.32 ± 2.26 43.89 ± 1.98
Model group 21.55 ± 1.78 51.72 ± 2.34 49.33 ± 2.13
Compare P<0.01 with model group
The influence of hemopoietic function after the chemotherapy
Group HB (g/L) PLT (* 109/L)
Treatment group I 91.03 ± 2.76 113.26 ± 7.91
Treatment group II 91.06 ± 2.45 112.47 ± 8.09
Treatment group III 90.98 ± 2.25 113.69 ± 8.11
Chemotherapy group 67.04 ± 1.78 92.56 ± 5.86
Model group 106.34 ± 4.95 97.12 ± 4.97
Compare P<0.05 with simple chemotherapy group
Mouse bone marrow cells nucleated cell result
The group bone marrow nucleated cell
Treatment group I 8.34 ± 0.17
Treatment group II 8.43 ± 0.16
Treatment group III 8.27 ± 0.15
Chemotherapy group 6.89 ± 0.24
Model group 10.11 ± 0.79
With the remarkable P of chemotherapy group comparing difference<0.05
As implied above, treatment group I, II, III, chemotherapy group neutrophilic granulocyte number average are higher than model control group (P<0.01); HB, the PLT value of treatment group I, II, III all are higher than chemotherapy group, two groups of comparing differences remarkable (P<0.05), and there was no significant difference (P〉0.05) between each group of WBC sum and lymphocyte percentage, explanation thus, Chinese medicine of the present invention to chemotherapy after the effect of hemopoietic function influential.Treatment group bone marrow nucleated cell value is higher than chemotherapy group, and is lower than model group, and treatment group I, II, III and chemotherapy group comparing difference be (P<0.05) significantly.Thus the explanation, chemotherapeutics is clear and definite to the bone marrow hematogenesis disorganization, the present invention to chemotherapy after bone marrow hematogenesis organize parenchyma to have protective effect.
The present invention tests Chinese medicine I, II, the III group has obvious facilitation to the blood Hb of hemolytic blood deficiency mice, the recovery of RBC value, can obviously prolong pentobarbital sodium threshold dose length of one's sleep, Rats with Spleen-deficiency gastric juice amount, gastric acid, pepsin activity are had obvious facilitation; Can strengthen mice endurance, hypoxia-bearing capability; Can obviously resist the decline of the peripheral blood T lymphocyte percentage that causes by hydrocortisone; Can resist the WBC decline that cyclophosphamide causes, protection ring phosphamide induced mice atrophy of thymus gland; Can improve deficient animal serum IgG content, strengthen immune function of mice.
In the clinical research, the QI and blood deficiency patient through 84 routine chemotherapy of tumors are caused carries out clinical verification, and 69 people are effective, and total effective rate is 82.1%, does not see obvious adverse reaction during the clinical observation.

Claims (10)

1. Chinese medicine of curing the QI and blood deficiency that chemotherapy of tumors causes, it is characterized in that the ratio of weight and number of various compositions is: 20~40 parts of the Radixs Astragali, 20~40 parts of Radix Angelicae Sinensis, 10~20 parts of Radix Codonopsis, 10~20 parts of Fructus Lyciis, 10~20 parts of Rhizoma Polygoni Cuspidati, 10~20 parts of Herba Centellaes, 10~20 parts of Rhizoma Chuanxiongs, 10~20 parts in Poria, 10~20 parts of Cortex Cinnamomis, 10~20 parts of the Rhizoma Atractylodis Macrocephalaes, 10~20 parts of Fructus Forsythiaes, 10~20 parts of Radix Saposhnikoviaes, 10~20 parts in Radix Rehmanniae Preparata, 10~20 parts of Radix Polygoni Multiflori, 10~20 parts in Colla Corii Asini, 10~20 parts in Radix Glycyrrhizae.
2. the Chinese medicine of the QI and blood deficiency that causes according to the described treatment chemotherapy of tumors of claim 1, it is characterized in that the ratio of weight and number of various compositions is: 30~40 parts of the Radixs Astragali, 30~40 parts of Radix Angelicae Sinensis, 10~20 parts of Radix Codonopsis, 10~15 parts of Fructus Lyciis, 10~15 parts of Rhizoma Polygoni Cuspidati, 10~15 parts of Herba Centellaes, 10~15 parts of Rhizoma Chuanxiongs, 10~15 parts in Poria, 10~15 parts of Cortex Cinnamomis, 10~15 parts of the Rhizoma Atractylodis Macrocephalaes, 10~15 parts of Fructus Forsythiaes, 10~15 parts of Radix Saposhnikoviaes, 10~15 parts in Radix Rehmanniae Preparata, 10~15 parts of Radix Polygoni Multiflori, 10~15 parts in Colla Corii Asini, 10~15 parts in Radix Glycyrrhizae.
3. the Chinese medicine of the QI and blood deficiency that causes according to the described treatment chemotherapy of tumors of claim 1, it is characterized in that the ratio of weight and number of various compositions is: 20~30 parts of the Radixs Astragali, 20~30 parts of Radix Angelicae Sinensis, 15~20 parts of Radix Codonopsis, 15~20 parts of Fructus Lyciis, 15~20 parts of Rhizoma Polygoni Cuspidati, 15~20 parts of Herba Centellaes, 15~20 parts of Rhizoma Chuanxiongs, 15~20 parts in Poria, 15~20 parts of Cortex Cinnamomis, 15~20 parts of the Rhizoma Atractylodis Macrocephalaes, 15~20 parts of Fructus Forsythiaes, 15~20 parts of Radix Saposhnikoviaes, 15~20 parts in Radix Rehmanniae Preparata, 15~20 parts of Radix Polygoni Multiflori, 15~20 parts in Colla Corii Asini, 15~20 parts in Radix Glycyrrhizae.
4. the Chinese medicine of the QI and blood deficiency that causes according to the described treatment chemotherapy of tumors of claim 1, it is characterized in that the ratio of weight and number of various compositions is: 30~40 parts of the Radixs Astragali, 30~40 parts of Radix Angelicae Sinensis, 10~15 parts of Radix Codonopsis, 10~15 parts of Fructus Lyciis, 15~20 parts of Rhizoma Polygoni Cuspidati, 15~20 parts of Herba Centellaes, 10~15 parts of Rhizoma Chuanxiongs, 10~15 parts in Poria, 10~15 parts of Cortex Cinnamomis, 10~15 parts of the Rhizoma Atractylodis Macrocephalaes, 10~15 parts of Fructus Forsythiaes, 10~15 parts of Radix Saposhnikoviaes, 10~15 parts in Radix Rehmanniae Preparata, 10~15 parts of Radix Polygoni Multiflori, 10~15 parts in Colla Corii Asini, 10~15 parts in Radix Glycyrrhizae.
5. the Chinese medicine of the QI and blood deficiency that causes according to the described treatment chemotherapy of tumors of claim 1, it is characterized in that the ratio of weight and number of various compositions is: 20~30 parts of the Radixs Astragali, 20~30 parts of Radix Angelicae Sinensis, 15~20 parts of Radix Codonopsis, 15~20 parts of Fructus Lyciis, 10~15 parts of Rhizoma Polygoni Cuspidati, 10~15 parts of Herba Centellaes, 10~15 parts of Rhizoma Chuanxiongs, 10~15 parts in Poria, 10~15 parts of Cortex Cinnamomis, 10~15 parts of the Rhizoma Atractylodis Macrocephalaes, 10~15 parts of Fructus Forsythiaes, 10~20 parts of Radix Saposhnikoviaes, 10~20 parts in Radix Rehmanniae Preparata, 10~20 parts of Radix Polygoni Multiflori, 10~20 parts in Colla Corii Asini, 10~15 parts in Radix Glycyrrhizae.
6. the Chinese medicine of the QI and blood deficiency that causes according to each described treatment chemotherapy of tumors in the claim 1~5 is characterized in that, described form of Chinese drug is decoction, powder, honey refining pill, hydration pill, tablet, capsule, oral liquid, granule or syrup.
7. the preparation method of Chinese medicine of a QI and blood deficiency that causes according to each described treatment chemotherapy of tumors in the claim 1~6 is characterized in that the dosage form of described Chinese medicine is a powder, and its preparation may further comprise the steps:
With described raw material water brush, wash clean, pull out and dry;
Radix Codonopsis, Rhizoma Chuanxiong, Poria, Cortex Cinnamomi, Radix Rehmanniae Preparata are put into the little fire of marmite respectively fried 5~10 minutes, respectively it is ground into smalls, sieve with pulverizer;
The Radix Astragali after will drying, Radix Angelicae Sinensis, Radix Polygoni Multiflori, Colla Corii Asini, Radix Glycyrrhizae are sent into respectively and are cut into flakelet in the microtome, again the raw material of above-mentioned processing and all the other raw materials are sent into pulverizer and are ground into smalls, sieve.
8. the preparation method of Chinese medicine of the QI and blood deficiency that causes according to the described treatment chemotherapy of tumors of claim 7 is characterized in that the used sieve that sieves is 90~110 orders.
9. the preparation method of Chinese medicine of the QI and blood deficiency that causes according to the described treatment chemotherapy of tumors of claim 7 is characterized in that the time of pulverizing is 10~15 minutes in pulverizer.
10. the preparation method of Chinese medicine of the QI and blood deficiency that causes according to the described treatment chemotherapy of tumors of claim 7 is characterized in that, described method further comprises the step that adopts ultraviolet radiation to carry out disinfection to mixed smalls.
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