CN101518594A - Anti-tumor immunity-enhancing traditional Chinese medicine preparation and preparation method thereof - Google Patents

Abstract

The invention discloses an anti-tumor immunity-enhancing traditional Chinese medicine preparation which comprises the following components by weight parts: 10-30 parts of ginseng, 2-7 parts of thunder god vine, 10-30 parts of lanceolata, 10-30 parts of astragalus, 10-30 parts of angelica, 10-30 parts of glaucescent fissistigma root, 10-30 parts of grey polypore, 10-30 parts of fleece-flower roots, 10-30 parts of spatholobus stems, 10-30 parts of dandelion, 10-20 parts of toad skin, 10-20 parts of gecko, 10-30 parts of safflower, 10-30 parts of medlar, 10-30 parts of cinnamon, 10-20 parts of hydnoid mushrooms, 10-30 parts of atractylodes and 10-30 parts of gamboges. The traditional Chinese medicine preparation by the scientific compatibility of medicines can tonify the kidney, einforce deficiency, activate and nourish blood, improve the autoimmunity of human bodies, promote blood circulation by removing blood stasis and dissolving lumps and effectively inhibit tumor growth.

Description

Chinese medicine preparation of a kind of antitumor and enhancing immunity and preparation method thereof

Technical field

The present invention relates to contain the medicinal preparation that derives from plant, animal or mineral component, particularly Chinese medicine preparation of antitumor and enhancing immunity and preparation method thereof.

Background technology

Chinese medicine thinks that the total cause of disease of tumor coagulates for qi depression to blood stasis expectorant, and the capable then blood of gas is capable, and the stagnation of QI is blood stasis then, and the deficiency of vital energy is blood deficiency then.Expectorant is also not normal because of gasification function, and water liquid fails to fail cloth, stop gathering, be detained and form.Drinking and eating irregularly, surgical injury, the course of disease with the passing of time all can cause the biochemical weary source, impaired, weak of QI and blood.Abnormal emotion can cause depression of liver-QI, disorder of QI movement; The spleen has the function to transport and transform nutrients the lucid yang sending up, stomach receiving food and drink is logical to fall, and movement of QI being out of order influence spleen and stomach function, and spleen and stomach function can cause insufficiency of generating and transforming QI and blood again, the formation of water damp-phlegm drink.About the primary disease origin cause of formation, the many duties of ancient medicine in empty, strongly fragrant, expectorant, the stasis of blood four ends.The basic reason of canceration process is that sickened body is before canceration, volt has disorder of YIN and YANG, zang-fu disharmony, healthy energy to lose the empty potential cause of disease, multiple long-time stimulus because of other factorses such as feelings will, diet, seasonal weather, regions, negative and positive are seriously lacked of proper care, function is extremely disorderly, it is sincere that healthy energy is lost empty day, finally causes canceration.

So cancer one of belongs in the oncosis malignant disease, and " cancer " is that words such as ancient times " rock ", " " are transformed, and be hard again and again because of its shape such as rock, high prominent uneven, get its pronunciation and meaning.The traditional Chinese medical science think primary disease many because of eating and drinking without temperance, seven emotions (happiness, anger, melancholy, think of, compassion, probably, frightened) excessively, etc. factor cause the human body imbalance of YIN and YANG, the pyretic toxicity heap soil or fertilizer over and around the roots is stagnant, qi depression to blood stasis is held concurrently QI and blood deficiency and is caused." element is asked the logical deficiency and excess opinion of commenting " said: " the diaphragm plug closes exhausted, and obstructed up and down, then disease due to intense worry also." illustrated that dysphagic morbidity is relevant with sudden and violent melancholy.Zhu Danxi thinks that breast carcinoma (cancer) is that " melancholy anger is gloomy, and gather morning and evening, the temper resistance that disappears, transverse invasion of hyperactive liver-QI " institute causes, says in " raving small house collection proved recipe ": " lid five kinds of masses in the chest and abdomen person, because of the gas of anger, melancholy, think of seven emotions to hinder five hollow organs, meet biography and restrain and not all rightly forms disease also." illustrate because seven emotions excessively can influence the function of five hollow organs, make it loss, easily recruit the exopathogen invasion, also can make functional activity of QI being not smooth, venation is obstructed, and qi depression to blood stasis forms cancer.

In recent years, along with the deterioration of living environment is polluted, cancer has become first killer of human health.The sickness rate of various cancers rises very fast.It is about 7,000,000 that at present the world dies from the malignant tumor number every year, the annual about 1,600,000 New Development tumor patients of China, and 105 die ten thousand deaths in this inducement.Malignant tumor has been first of various diseases death in the city, and has and increase trend year by year.The method of clinical treatment malignant tumor is varied, comprises operative treatment, radiotherapy, chemotherapy and the combined therapy of Chinese and Western medicine etc.

Though ocal resection is one of the most extensive, effective means, and is bigger to patient's wound, and can not excise small subclinical focus, also has the come off possibility of plantation of oncocyte; The putting of postoperative, chemotherapy can be killed residual cancer cell, have also that specificity is relatively poor, the part tumor cell has weak points such as drug resistance phenomenon.The doctor trained in Western medicine chemicotherapy is one of critical treatment method of malignant tumor.The chemotherapy malignant tumor has basically formed a complete theoretical system since the application of nineteen forty-six chlormethine.But because most of chemicals poor selectivity, the physiological function to normal structure and internal organs after the medication has certain destruction, often causes chemotherapy treatment and a series of toxicities such as can not finish.Mainly show as: bone marrow depression; Digestive tract reaction; Immunologic hypofunction etc.Though the method curative effect of the various control chemotherapy toxic side effects of modern medicine certainly, as blood transfusion, sharp blood liter, hemopoietic growth factor, ondansetron etc.; But also there are many problems in these present methods, have inadequate blood source as blood transfusion, and paathogenic factor gets more and more and limits its use in the blood; Hemopoietic growth factor can promote that the leukaemia breeds, and suppress the cytotoxicity chemotherapeutics and bring out the acute leukemia cells apoptosis, and the bone marrow that can not solve chemotherapy damages outward, has dispute so hemopoietic growth factor used.Simultaneously, these drug mains will work from single angle, integrally-regulated poor effect; And cost an arm and a leg, clinical use is limited.At present, the traditional Chinese medical science focuses mostly in human body immunity improving power for the research for the treatment of malignant tumor, strengthen the patient to put, the sensitivity of chemotherapy, anticancer propagation and promote aspect such as cancer cell-apoptosis.

Diarrhoea, unsatisfactory curative effect behind western medicine appear in part patient behind chemicotherapy.Owing to can not distinguish useful cell of each organ of health or cancerous cell, often all destroy during chemicotherapy, greatly damage the sufferer health.Get cancer again because deficiency of QI in middle-JIAO own causes cancer patient's health during chemicotherapy extremely weak.Because chemicotherapy often has more toxicity, and patient's individual variation, makes the part patient be difficult to accept omnidistance chemicotherapy, treatment cancer effect is had a greatly reduced quality.Along with the continuous appearance of high efficiency anti-tumor medicine, chemotherapy is used increasingly extensive in treating malignant tumor.But chemotherapy can cause bone marrow depression to some extent, and is wherein more obvious with short leukocytic minimizing of life-span, thereby influences chemotherapy.In all chemotherapy process, or behind radiating irradiation, stomachache, diarrhoea, tenesmus, hemafecia symptom occur, doctor trained in Western medicine is used antibacterial drug therapies such as the antibiotic of capacity such as norfloxacin usually, and like based on eliminating evil, but curative effect is very little.Strengthening the body resistance is the traditional Chinese medical science rule of treatment commonly used of clinical treatment malignant tumor.Chinese traditional treatment often takes effect slowly, and curative effect is barely satisfactory, and specific aim is not strong, and the cycle is very long.Up to now, domestic and international method and the measure that does not occur as yet the well-content therapeutic effect of primary disease.For this reason, press for clinically and can effectively rise the medicine that blood can improve patient's functional status again.

Summary of the invention

Technical problem to be solved by this invention is, Chinese medicine preparation of a kind of antitumor and enhancing immunity and preparation method thereof is provided, tumor at various degree, and treat cancer on the market, the curative effect of medication of tumor is undesirable, the slower shortcoming that takes effect in conjunction with clinical experience for many years, adopts modern processing method to develop meticulously on the basis of traditional medicine.The present invention is that a kind of quick result, effect continue Chinese medicine preparation of a specified duration to each effective ingredient science compatibility of component medicine, the combination of inner and outside, and treating both the principal and secondary aspects of a disease can solve patient's misery to a certain extent; Simultaneously this medicine can also with the radiotherapy of various cancers, chemotherapy in be used, have heightening the effect of a treatment, alleviate the effect of side effect, improve patient's immunity.

For solving the problems of the technologies described above, it is simple to the invention provides a kind of prescription, the Chinese medicine preparation of simple antitumor of processing technology and enhancing immunity, the ratio of weight and number of various components is in the described medicine: 10～30 parts of Radix Ginsengs, 2～7 parts of Radix Tripterygii Wilfordiis, 10～30 parts of Radix Codonopsis, 10～30 parts of the Radixs Astragali, 10～30 parts of Radix Angelicae Sinensis, 10～30 parts of Radix Fissistigmatis Glaucescentiss, 10～30 parts of Grifola frondosa, 10～30 parts of Radix Polygoni Multiflori, 10～30 parts of Caulis Spatholobis, 10～30 parts of Herba Taraxacis, 10～20 parts of Cutis Bufonis, 10～20 parts of Gekko Swinhonis Gekko Swinhonis, 10～30 parts on Flos Carthami, 10～30 parts of Fructus Lycii, 10～30 parts of Cortex Cinnamomis, 10～20 parts of Hericium erinaceus (Bull. Ex Fr.) Pers., 10～30 parts of the Rhizoma Atractylodis Macrocephalaes, 10～30 parts of Resina garciniaes.

The Chinese medicine preparation of described antitumor and enhancing immunity, the ratio of weight and number of various components can be preferably: 10～15 parts of Radix Ginsengs, 3～5 parts of Radix Tripterygii Wilfordiis, 10～15 parts of Radix Codonopsis, 10～15 parts of the Radixs Astragali, 10～15 parts of Radix Angelicae Sinensis, 10～20 parts of Radix Fissistigmatis Glaucescentiss, 10～20 parts of Grifola frondosa, 10～15 parts of Radix Polygoni Multiflori, 10～15 parts of Caulis Spatholobis, 10～15 parts of Herba Taraxacis, 10～15 parts of Cutis Bufonis, 10～15 parts of Gekko Swinhonis Gekko Swinhonis, 10～20 parts on Flos Carthami, 10～15 parts of Fructus Lycii, 10～15 parts of Cortex Cinnamomis, 10～15 parts of Hericium erinaceus (Bull. Ex Fr.) Pers., 10～15 parts of the Rhizoma Atractylodis Macrocephalaes, 10～15 parts of Resina garciniaes.

The Chinese medicine preparation of described antitumor and enhancing immunity, the ratio of weight and number of various components can also be preferably: 10～20 parts of Radix Ginsengs, 4～6 parts of Radix Tripterygii Wilfordiis, 10～20 parts of Radix Codonopsis, 10～20 parts of the Radixs Astragali, 10～20 parts of Radix Angelicae Sinensis, 10～15 parts of Radix Fissistigmatis Glaucescentiss, 10～15 parts of Grifola frondosa, 10～20 parts of Radix Polygoni Multiflori, 10～20 parts of Caulis Spatholobis, 10～15 parts of Herba Taraxacis, 10～15 parts of Cutis Bufonis, 10～15 parts of Gekko Swinhonis Gekko Swinhonis, 10～15 parts on Flos Carthami, 10～20 parts of Fructus Lycii, 10～15 parts of Cortex Cinnamomis, 10～15 parts of Hericium erinaceus (Bull. Ex Fr.) Pers., 10～20 parts of the Rhizoma Atractylodis Macrocephalaes, 10～20 parts of Resina garciniaes.

The Chinese medicine preparation of described antitumor and enhancing immunity, the ratio of weight and number of various components also can be preferably: 15～25 parts of Radix Ginsengs, 3～7 parts of Radix Tripterygii Wilfordiis, 15～25 parts of Radix Codonopsis, 15～25 parts of the Radixs Astragali, 15～25 parts of Radix Angelicae Sinensis, 10～25 parts of Radix Fissistigmatis Glaucescentiss, 15～25 parts of Grifola frondosa, 10～25 parts of Radix Polygoni Multiflori, 10～25 parts of Caulis Spatholobis, 10～25 parts of Herba Taraxacis, 10～15 parts of Cutis Bufonis, 10～15 parts of Gekko Swinhonis Gekko Swinhonis, 15～25 parts on Flos Carthami, 15～25 parts of Fructus Lycii, 15～25 parts of Cortex Cinnamomis, 10～20 parts of Hericium erinaceus (Bull. Ex Fr.) Pers., 15～25 parts of the Rhizoma Atractylodis Macrocephalaes, 15～25 parts of Resina garciniaes.

The Chinese medicine preparation of described antitumor and enhancing immunity is fried in shallow oil decoction in use and is taken, and can obey at twice by decocting 1 dose of every day, and per 7 days is a course of treatment.

The Chinese medicine preparation of described antitumor and enhancing immunity, the dosage form of medicine can also be honey refining pill, hydration pill, capsule, oral liquid, granule, colloid, syrup or drop.

The Chinese medicine preparation of described antitumor and enhancing immunity, pharmaceutical dosage form is tablet or powder, when taking, can one day three times, per 7 days is a course of treatment.

For solving the problems of the technologies described above, the present invention also provides the preparation method of the Chinese medicine preparation of a kind of antitumor and enhancing immunity, and described pharmaceutical dosage form is a capsule, and its preparation process comprises:

According to described portion rate with Cutis Bufonis and Gekko Swinhonis Gekko Swinhonis with 95% soak with ethanol three times, each soak time was respectively 2 hours, 1 hour, 1 hour; Each 80～85 ℃ of heat in back of soaking are extracted; The ratio of weight and number of used ethanol and Cutis Bufonis and Gekko Swinhonis Gekko Swinhonis is respectively: for the first time 10 times of amounts, the second time 6 times of amounts, 6 times of amounts for the third time; Merge three times ethanol extract, be concentrated into relative density and be 1.06 concentrated solution, stand for standby use; Residue after the aforementioned extraction and other described components merge, and 80～100 ℃ of decoctings boil three times, and decocting time was respectively 2 hours, 1.5 hours, 1 hour; The ratio of weight and number of institute's water and residue and other component gross weights is respectively: for the first time 10 times of amounts, the second time 8 times of amounts, 6 times of amounts for the third time; Merge three times decoction liquor, be concentrated into relative density and be 1.08 concentrated solution; With decocting and concentrating liquid and the merging of ethanol concentrated solution, filtration, spray drying, granulation, encapsulated again.

For solving the problems of the technologies described above, the present invention provides the preparation method of the Chinese medicine preparation of a kind of antitumor and enhancing immunity again, and described pharmaceutical dosage form is a powder, and its preparation process comprises:

Described component was soaked 30 minutes to 1 hour, and heating was boiled 30～40 minutes, filtered filtrate for later use; Filtering residue adds water and heats for the second time, boils 30～40 minutes, filters filtrate for later use; Filtering residue adds water again, and heated and boiled is 40～50 minutes for the third time, filters; Three filtrates are lumped together, and heating is concentrated into pasty state, puts into 80 ℃ in baking oven oven dry postcooling, grinds to form fine-powdered, the powder Chinese patent medicine.

For solving the problems of the technologies described above, the present invention provides the preparation method of the Chinese medicine preparation of a kind of antitumor and enhancing immunity again, and described pharmaceutical dosage form is a powder, and its preparation process comprises:

Described component is mixed by proportioning, drop into pulverizer and be ground into fine powder, put into the acid and alkali-resistance infusion kettle after fine powder sieves, at normal temperatures, flooded 15～30 days with ethanol is common, liquid and medicinal residues that dipping is good carry out squeeze and filter, get filtrate after the separation, the filtrate heating is concentrated into pasty state, put into the oven for drying postcooling, grind to form fine powder, the powder Chinese patent medicine.

The present invention adopts the Chinese crude drug of the different property of medicine, has carried out the science compatibility, can reach ideal therapeutic effect, and safety, can effectively alleviate the sufferer misery, improves patient's quality of life.To improving pain that tumor body compressing causes and hemorrhagely having a good and clinical curative effect, and general situation such as the spirit, appetite, sleep etc. of obviously improving the patient, and side effect is little, treatment safety, convenient, can palliate the agonizing sufferings, prolong life, especially remarkable to the quality of life effect that improves patients with advanced cancer.Simultaneously this medicine can also with the radiotherapy of various cancers, chemotherapy in be used, have heightening the effect of a treatment, alleviate the effect of side effect.To not accepting the patient with advanced cancer of radiotherapy, chemotherapy, operative treatment, this medicine is ideal selection.The present invention is easy to use, selects for use medical material cheap, and manufacture method is simple, can create good social and be worth and economic interests

The specific embodiment

Malignant tumor is a class common disease of serious threat human health, seeks effective cancer therapy drug and method, is the important topic that world medicine faces.Chinese medicine is that motherland's medical science is used for the powerful mean of disease preventing and treating, it is found that the treatment by Chinese herbs malignant tumor, no matter is to alleviate clinical symptoms, improve life quality, prevent relapse and metastasis, prolong life cycle, still cooperating with chemicotherapy, all there is good effect aspects such as efficacy enhancing and toxicity reducing.The generation development of malignant tumor is multifactor, multistage complex process, and the long-term accumulation of various tumor-related gene unconventionality expressions is the important steps in the canceration process.Chinese medicine is main by setting upright, and eliminating evil is auxilliary, and the means for the treatment of both the principal and secondary aspects of a disease had both been trained and mended temper, has removed damp and hotly again, that is to say, has both adjusted alteration of intestinal flora, has suppressed the growth of antibacterial again.Guarantee proceeding of chemicotherapy, in the Comprehensive Treatment of malignant tumor, had important function.

Chemotherapeutics or radiation treatment consume the body healthy energy of hurting sb.'s feelings, and the impairment of the spleen is upset one's stomach, and makes deficiency-weakness of spleen-QI, transformation failure of spleen, and dysfunction of the spleen in transportation, stomach-QI being unable to descend normally, water paddy is reforming not, gives birth to heat of wetting, the large intestine that becomes under water is wet, damp-heat accumulation, it is not normal to cause the large intestine conduction function.So see diseases such as nausea and vomiting and diarrhoea." have loose bowels originally, as " Jing Yue's complete work is had loose bowels " is so-called invariably because taste." primary disease damp and hot, can not transport wetly in fact by insufficiency of the spleen, wetly accumulate heat-transformation and form, so it is for marking, this of disease is then in the void of temper.So treatment should be an elder generation to set upright, in case healthy energy is recovered, pathogen is retreated naturally.Giving consideration to both the incidental and fundamental, air making-up and spleen enlivening is held concurrently with clearing away heat and eliminating dampness to control its mark with Zhi Qiben emphatically.

The category that malignant tumor belongs to traditional Chinese medical science abdominal mass, gathers.Motherland's theory of medicine thinks that the weakness of the generation of cancer (amassing) and body resistance against diseases (healthy energy) has substantial connection.Healthy energy is deficient be cancer (amassing) morbidity main diseases because of." interior warp " cloud: " in healthy energy deposits; heresy can not be done ", " institute of heresy gathers; its gas must be empty " " exterior symptoms the doctor compile " further bring into play ": the positive deficiency of vital energy is diagenesis then " ", medical science heart method " also emphasize " long-pending one-tenth also, positive QI-insufficiency, then pathogen is crouched it ", the generation of cancer all is described, is mostly on weakened body resistance basis, to produce.Deficiency of vital QI, imbalance of YIN and YANG, internal organs void declines, and evil poison is taken advantage of a weak point, and heresy just disaccords, vital QI cannot conquer pathogen, evil poison cohesion forms malignant tumor, the multiple abscess that overflows, then the tumor poison shifts all over.Its pathogenic characteristic is for falling ill because of empty, because of the empty reality that causes.The traditional Chinese medical science is always advocated " treatment of disease must aim at its pathogenesis ", in addition middle and terminal cancer patient's healthy energy is deficient particularly outstanding, therefore, establishes the strengthening the body resistance rule of treatment, sets about from the enhancing body resistance against diseases, eliminates tumor to drive away.Said just as golden Zhang Zihe: " just winning then heresy but, heresy is gone to then Zhengan County ".Cancer is many with hyperactivity of toxic heat, qi depression to blood stasis, and deficiency of both QI and blood is main syndrome, so based on heat-clearing and toxic substances removing, be aided with regulating the flow of QI to dissipate blood stasis, benefiting vital QI and blood is prescription rule of treatment and prescription, has embodied the characteristic of tcm treatment according to syndrome differentiation; Aspect the selecting for use of medicine, need not high strict product, and with the gentle medicine of the property of medicine, embodied drug safety, effectively " seen " to use characteristics in flat strange.Chinese medicine preparation compatibility of the present invention is rigorous, eliminating evil with set upright and execute, play the merit of heat-clearing and toxic substances removing, regulating the flow of QI to dissipate blood stasis, benefiting vital QI and blood, function of spleen and stomach regulating altogether, thus cancer is seen that hyperactivity of toxic heat is arranged, qi depression to blood stasis, QI and blood deficiency, what weakness of the spleen and stomach was used can obtain effect.With the strengthening the body resistance is the main treatment advanced malignant tumor, and obviously relief of symptoms dwindles the tumor body, suppresses tumor growth, prevents that tumor recurrence from shifting, and improves life quality, prolongs life span.

The traditional Chinese medical science thinks that yang-energy is not multiple, and pathogenic heat are flourishing, and good and evil are handed over and striven, the consume of cloudy Tianjin.The epidemic febrile disease pathogenic heat are flourishing, go deep into nutrient blood, tie mutually with blood, and the absurd row of forcing blood, or QI and blood is deficient, can not fill sering, the capable stasis of blood of slowly holding under the arm of blood.No matter be stagnant heat resistance network, still blood deficiency is held the stasis of blood under the arm, or the unable fortune blood of the deficiency of vital energy, or the stagnation of QI can not promoting the circulation of blood, has all caused disorder of QI and blood, stagnant, the blood stasis of the blood flow stasis of blood.Radix Ginseng strongly invigorating primordial QI, spleen invigorating are promoted the production of body fluid, and " Bencao Jingshu " said: " Radix Ginseng can cut off in hanging down by recuperating depleted YANG gas, and but exogenous pathogen is in a moment.It cures mainly also, then tonifying five ZANG-organs." Radix Astragali invigorating the spleen and replenishing QI, diuretic granulation promoting, " herbal classic is dredged card " said: " Radix Astragali, so soil in directly going into and row three warmers are can interior invigorating middle warmer gas." two medicines share, warm first whole body is inspired QI and blood, the vigor of excitating organism life; Second QI invigorating, the prosperous then blood of gas is given birth to, and the prosperous then blood of gas is capable, but both health invigorating can be set upright with eliminating evil again.Have now found that deficiency syndrome all have immunologic hypofunction or disorder in various degree generally, and modern pharmacological research shows that also Radix Ginseng has antitumor, strengthen and regulate the effectiveness of body's immunity.But but ginsenoside and monomer Re thereof, Rd are subjected to the T cell function of mice in external enhance immunity, and scalable cell and humoral immune reaction, can suppress the propagation of tumor cell by inducing differentiation or apoptosis.Astragalus polysaccharides, saponin can improve immune function of human body, strengthen the cell physiological metabolism, improve macrophage activity, be ideal immunostimulant, it can promote the function of immunocytes such as T cell, B cell, NK cell, and panimmunity defective diseases such as acquired immune deficiency syndrome (AIDS) are all had good preventive and therapeutic effect, suppress EAS in addition, effects such as two-ways regulation blood glucose, delaying cell aging helps life lengthening.When astragalus polysaccharides and ginseng polysaccharide's compatibility, can significantly improve active anticancer, reduce chemotherapy side effect, use this medicine after cancer patient's chemotherapy, obviously the counting of leukocyte increasing.

The Radix Astragali is based on tonify deficiency, can invigorating QI to consolidate the body surface resistance, and diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.Be used for that insufficiency of vital energy and blood, skin infection cave in, difficulty in discharging of pus or burst for a long time and do not hold back the person.The Radix Astragali has the function of good promoting pus discharge and tissue regeneration strengthening, i.e. the abscess suppuration granulation promoting of disunion for a long time.Modern medicine study shows that the Radix Astragali includes and multiple antibiotic effective ingredient, and the energy enhancing body's immunological function, therefore can also be used to prevent the generation of some infectious disease." book on Chinese herbal medicine meets former " carries: " Radix Astragali can all void of tonifying five ZANG-organs, controls the stringy pulse spontaneous perspiration, rushes down YIN-fire, removes lung-heat, losslessly then sends out, and has antiperspirant then to end." be the good medicine of promoting resistance and defence disease.

Fructus Lycii is a liver and the kidney tonifying commonly used simply, the Chinese medicine of enhancing immunity.Modern medicine study confirms that it contains nutritional labelings such as betaine, polysaccharide, crude fat, crude protein, carotene, vitamin A, vitamin C, vitamin B1, vitamin B2 and calcium, phosphorus, ferrum, zinc, manganese, linoleic acid, hemopoietic function there is facilitation, can also defying age, effect such as mutation, antitumor, anti-fatty liver and blood sugar lowering.The traditional Chinese medical science usually with it treat hepatic and renal YIN deficiency, soreness of the waist and knees, dizziness, forgetful, dizzy, many tears of blurred vision, quench one's thirst, poliosis, alopecia, it is remarkable that diseases such as seminal emission, YIN nourishing are supported the kidney effect.

Radix Angelicae Sinensis, its sweet in the mouth and weighing, so specially can enrich blood, its gas is light and hot, thus again can promoting the circulation of blood, invigorating middle warmer has, in the row benefit is arranged, the gas medicine in the sincere blood, the also panacea in the blood.About mending of assistant to mend then, thus can support nutrition blood, the QI invigorating spermatogenesis, settling five organs, body by force, beneficial mind, all tangible deficient diseases, nothing is unsuitable.Assistant logical to attack then, so the relieving constipation bitterly of dispelling, relieving rigidity of muscles and joints is controlled contracture, paralysis, card such as dry, puckery.Nutrient QI being deficient and exterior syndrome being not relieved person, assistant is with agent such as bavin, Pueraria lobota, fiber crops, osmanthus, the Biao Weire that can loose greatly, and show not hold back the person, and help with Radix Et Rhizoma Rhei and so on, again can consolidating superficial resistance.Precisely because gas Xin Erdong, so desire its quiet person when keeping away it, the sliding benefaction of property is defecated and is not consolidated the person when keeping away it.All cloudy moderate heat Sheng persons, the active blood of Radix Angelicae Sinensis, also non-institute is suitable, cloudy deficiency of YANG of middle-JIAO person, Radix Angelicae Sinensis can nourish blood, and is indispensable.Also be the good medicine that improves body immunity.

Radix Codonopsis is flat, sweet in the mouth, little acid.Return spleen, lung meridian.Invigorating the spleen and replenishing QI, the spleen invigorating lung benefiting.Be used for deficiency of the spleen and lung, the cardiopalmus of breathing hard, anorexia and loose stool, the dyspnea due to deficiency cough, interior-heat is quenched one's thirst." book on Chinese herbal medicine justice " carries: Radix Codonopsis power energy spleen reinforcing nourishing the stomach, and the lung moistening and production of body fluid promoting, gas in the tendon fortune, this is very mutually not far away with Radix Ginseng.Its outstanding valuable person, spleen invigorating fortune and not dry is then grown stomach-Yin and wet, and lung moistening and do not violate is cold and coolly nourished blood and is not grown greasyly partially, inspires clear sun, gas in the vibration, and do not have dry fraud just.Radix Astragali QI invigorating, can rise enriching spleen-QI, again can the lung benefiting consolidating superficial resistance.The Radix Codonopsis QI invigorating can only the spleen invigorating QI invigorating, the power of no consolidating superficial resistance, but Radix Codonopsis can also supplementing QI for promoting the production of body fluid, and the Radix Astragali does not then have the effect of promoting the production of body fluid, and the Radix Astragali is held concurrently can diuretic, and Radix Codonopsis does not have the diuretic effect.This two flavors medicine share can invigorating the spleen and replenishing QI, improves immunity.

Radix Tripterygii Wilfordii, bitter, hot, cold.Very toxic.A small amount of utilization can be treated tumor.Include multiple alkaloid such as wilfordine, wilfordine, diterpenoid-lactone, triptonide and dulcitol etc.Wilfordine, wilfordine and diterpenoid-lactone, dulcitol all have tangible anti-tumor activity, to mouse leukemia 1210, P388 and human nasopharyngeal carcinoma all have inhibitory action animal experiment and some clinical researches to prove, Radix Tripterygii Wilfordii can suppress the tumor cell of too fast division growth, therefore has anticancer effect.

Radix Fissistigmatis Glaucescentis nature and flavor hardship, be slightly cold, have effects such as antiinflammatory, heat-clearing and toxic substances removing, relieving cough and asthma, removing obstruction for relieving pain, main product is in Yunnan. contain number of chemical compositions such as multiple steroidal ester glycosides, alkaloid, organic acid, polysaccharide, resin and pigment, tradition is used for cough, asthma, productive cough is coughed and breathed heavily, cure mainly tracheitis, bronchial asthma.Have immunomodulating, protect the liver diuresis, effect such as anticancer relieves internal heat.And the Chinese medicine that unique chemical constituent that Radix Fissistigmatis Glaucescentis contains the is prepared from cancer that disappears is flat, and kinds of tumors such as gastric cancer, hepatocarcinoma are had definite antitumor curative effect, is a kind of up-and-coming antitumor Chinese medicine.The cancer-resisting substance that contains a kind of mystery in this plant---black bone carcinocidin (C21-steroidal glycoside and black bone total alkali), it is arranged with very strong destruction to the splitted root～microtubule of cancerous cell, can block the mitosis of cancerous cell, thereby effectively cut off cancerous cell diffusion, shift, cancer therefore and atrophy until complete obiteration.

Grifola frondosa has high medical health care function.According to reported in literature, it has the effect that suppresses hypertension and obesity; Owing to be rich in ferrum, copper and vitamin C, it can prevent anemia, vitamin C deficiency, vitiligo, prevents the generation of arteriosclerosis and cerebral thrombosis; Its selenium and chromium content are higher, and the liver protecting, pancreas are arranged, the effect of prevention liver cirrhosis and diabetes; The Se content height makes it also have the Keshan disease of control, Kaschin-Beck disease and some cardiopathic function; Its double calcic and vitamin D, both cooperate, and can prevent and treat rickets effectively; The higher favourable brain development of zinc content, maintenance oxyopia promote wound healing; High-load vitamin E and selenium cooperate, and make it defying age, memory reinforcing and sensitivity.Grifola frondosa still is noticeable anticarcinogen source, on the one hand, higher Se content has the effect of the cancerous protuberance of resisting, and especially contained grifolan (Grifolan) is based on beta glucan (glucan), wherein active anticancer is the strongest, β-(1,3)-glucosan with 6 side chains accounts for quite great proportion, it is said than the lentinan (Lentinan that has appeared on the market, the PSK of Japan), krestin (PSP in Shanghai) etc. has stronger anti-cancer ability; It is again fabulous immunomodulator simultaneously.As Chinese medicine, Grifola frondosa and Polyporus equivalence can be controlled dysuria, edema, beriberi, cirrhotic ascites and diabetes etc., are very valuable medicinal fungis.

Radix Polygoni Multiflori nature and flavor hardship, sweet, puckery, temperature.Return liver, the heart, kidney channel.Compendium of Material Medica record " this thing temperature, bitter and puckery flavor.Bitter the kidney invigorating, the temperature compensation liver wetly can be restrained vital essence.The liver benefiting so can nourish blood, the controlling nocturnal emission with astringent drugs kidney tonifying, muscle reinforcing and bone strengthening, black moustache is sent out, and is tonic medicine, and is cold not dry, and merit is on Radix Rehmanniae, day doorway winter thread medicine." but the treating the liver kidney yin loses, sending out must be early white.The Chinese medicine theory is thought, Radix Polygoni Multiflori nature and flavor hardship, sweet, puckery, tepor, effect such as have tonifying liver, kidney tonifying, nourish blood, dispel the wind is applicable to diseases such as hepatic and renal YIN deficiency, early whitening of beard and hair, blood deficiency dizziness, soreness of the waist and knees, muscles and bones are ached, seminal emission, metrorrhagia and leukorrhagia, chronic dysentery, chronic hepatitis, carbuncle, scrofula, hemorrhoidal hamorrhage, hemorrhoid, lupus erythematosus.Modern medicine confirms that the anthraquinones in the Radix Polygoni Multiflori has effects such as cholesterol reducing, blood sugar lowering, antiviral, heart tonifying, promotion gastrointestinal peristalsis, promotes the fibrinolytic activity effect in addition, and cardiovascular and cerebrovascular disease is had certain preventive and therapeutic effect; Contained lecithin is the component of cerebral tissue, hemocyte and other cell membrane in the Radix Polygoni Multiflori, and often edible Radix Polygoni Multiflori has therapeutical effect to diseases such as neurasthenia, poliosis, alopecia, anemias, therefore, and delaying sanility, building body, health care heart.Zoopery proves that Radix Polygoni Multiflori also has antitumor action.Simultaneously, modern pharmacological research is found the multiple materials such as lecithin, anthraquinone derivative and chrysophanol that Radix Polygoni Multiflori contains, can suppress cholesterol rising, reduce cholesterol in intestinal absorption, can prevent that cholesterol from depositing in tissue, thereby can alleviate atherosclerotic formation, its cholesterol reducing of clinical research confirmation and triglyceride total effective rate reach more than 80%.Radix Polygoni Multiflori also has the effect of strong nerve, but nourishing the brain and improving intelligence, and can promote the g and D of hemocyte has significant anti-aging effects.The often edible Radix Polygoni Multiflori of middle age can prevent the generation and the development of senilism.

Gekko Swinhonis goes the dry products of internal organs to go into Chinese medicine, and name " Gekko Swinhonis Gekko Swinhonis " has tonifying the lung kidney, benefiting essence-blood, relieving cough and relieving asthma, spasmolytic to dispel the wind and disperses the repercussive effect, can control lymphoid tuberculosis, neuralgia, chronic arthritis, lump in breast.Salty in the mouth, cold.Slightly poisonous.Cure mainly and dispel the wind, active, eliminating stagnation.Be used for paralysis due to windstroke, rheumatic arthritis, osteomyelitis, tuberculous lymphadenitis, tumor.Be the good medicine of the various tumors of treatment.

Flos Carthami is warm in nature, acrid in the mouth.Function cures mainly and is applied to invigorate blood circulation latus rectum, eliminating stasis to stop pain.Be used for that amenorrhea, dysmenorrhea, lochia are not all right, lump in the abdomen mass in the abdomen, traumatic injury." book on Chinese herbal medicine converges and says ": Flos Carthami, the medicine of removing blood stasis, promoting the circulation of blood and blood, accent blood also.Main tire produces all kinds of diseases and ailments and is trouble because of blood, or the tired bruise of blood, and coma in silence; Or lochia is robbed the heart, the umbilicus angina abdominis; Or the drop slurry is difficult living; Or afterbirth do not fall, and dead fetus in the uterus is all just before giving birth all cards, and non-Flos Carthami can not be controlled.If puerperal blood faints, locked mouth refer to hold in the hand; Or heresy goes into the blood chamber, and delirium is gone mad; Or blood expands in vexed, and the sudden syncope with rigidity is as extremely, be all puerperal all cards, non-Flos Carthami can not be decided.All friendship as the obstructed and cold and heat of amenorrhea done, or expired stomachache and purple black dripping, or injury from falling down and the QI and blood stasis of blood is long-pending, or skin infection sufferings and swollenly burst uneasyly, is cards of disharmony between QI and blood all, and non-Flos Carthami can not be transferred.

The Cortex Cinnamomi extremely hot in nature, acrid in the mouth, sweet.It is supporing yang that function is mended fire, let the fire back to its origin, dispersing cold for relieving pain, promoting blood circulation to restore menstrual flow.Be used for sexual impotence, cold womb, trusted subordinate's cold type of pain, deficiency and coldness vomiting and diarrhoea, amenorrhea, dysmenorrhea, warming the meridian and promoting blood circulation." not Lu " carries it: main pained, side of body wind, hypochondriac pain, warm muscle is promoted blood circulation, end tired, perspire.Main warming middle-JIAO, benefitting liver and lung gas, trusted subordinate's cold and heat, cold disease, cramp caused by acute vomiting and diarrhea, headache, lumbago is ended saliva, cough, nose; Can have an abortion, hard joint, promoting blood circulation, reason is dredged not enough; A surname leads hundred medicines, and nothing is feared.It has sedation to the central nervous system modern medicine study.The cinnamic aldehyde that contains in the Cortex Cinnamomi has tangible sedation to mice, show as spontaneous activity and reduce, the movement disorder of crossing multi-activity, rotating stick test generation that antagonism methamphetamine (Methamphetamine) is produced and the anesthesia duration of prolongation ciclobarbital soluble etc.Use mice press anal spine to swash or lumbar injection acetic acid observe turn round the body motion the method proof it analgesic activity is arranged.So be the good complementary medical material of radiotherapy chemotherapy.

Hericium erinaceus (Bull. Ex Fr.) Pers. is a kind of medicine-food two-purpose fungus.Hericium erinaceus (Bull. Ex Fr.) Pers. property is flat, and sweet in the mouth can sharp the five internal organs, aid digestion, nourishing, anticancer, treatment neurasthenia, domesticly has been widely used in curing digestive system disease such as dyspepsia, gastric ulcer, duodenal ulcer, esophageal carcinoma, gastric cancer.Modern medicine study finds, the hereditary material of hedgehog hydnum in can anticancer synthetic, thus can prevent alimentary tract cancer and other malignant tumor.Curative effect to digestive tract disease such as gastric ulcer, duodenal ulcer, gastritis attracts people's attention.Hericium erinaceus (Bull. Ex Fr.) Pers. has higher medical value, and is aid digestion, and sharp the five internal organs have special curative effect to gastric ulcer, duodenal ulcer and neurasthenia etc., and can improve the immunity of human body.Contain polysaccharide, polypeptides matter in the Hericium erinaceus (Bull. Ex Fr.) Pers., tumor in the digestive tract is had certain treatment and inhibitory action.

Cutis Bufonis also claims the toad clothing in the Chinese medicine, be that Bufo siccus sloughs off the epidermis coating that gets off naturally, can remove stupid evil tumor also, it is the vital essence of its five internal organs six lungs, receives the China in the negative and positive world precious, controls foul disease with it, do not have and do not heal, select from the Li Shizhen (1518-1593 A.D.) Compendium of Material Medica, be known as anticancer good medicine by the expert.Anticancer pharmacology: lipid material is to mice S180, rabbit B, P tumor, cervical cancer 14, ascitic type liver cancer etc. in the toadpoison, inhibitory action is all arranged, lower jaw undifferentiated carcinoma on the cheekbone that can suppress the people on the body, inhibitory action is all arranged, the breathing of tumor cells such as lower jaw undifferentiated carcinoma, carcinoma mesothelial, gastric cancer, sarcoma of spleen, hepatocarcinoma on the cheekbone that can suppress the people on the body, in test tube, the leukaemia there is inhibitory action.Well-known Venenum Bufonis is a kind of toxic herb, if single cause poisoning easily with Venenum Bufonis is excessive, and the present invention uses Cutis Bufonis to replace Venenum Bufonis, then can play antitumor action, be unlikely to contain the peptide constituents----anticancer peptide of antitumor action again as the bad control of Venenum Bufonis, therefore its tumor-inhibiting action is stronger, but is unlikely to cause poisoning.

The Resina garciniae detumescence, removing toxic substances, hemostasis, parasite killing.Control swollen ulcer drug, stubborn dermatitis malignant boil, bleeding due to trauma, ulcerative gingivitis decayed tooth, burn.Resina garciniae has stronger bacteriostasis to staphylococcus aureus, and alcoholic solution has strong bacteriostasis to bacillus pyocyaneus.Gamlogic acid shows stronger anti-tumor activity to kinds of tumors, and toxic and side effects is smaller in effective dosage ranges, inhibition to tumor cell has very high selectivity, kill cancer cell optionally, and to intact animal's hemopoietic system and not influence of immunologic function, this is that present tumor chemotherapeutic drug is not available.Pharmacokinetic also shows that gamlogic acid has higher distribution and long persistent period in tumor tissues.Gamlogic acid is the broad-spectrum anti-tumor medicine, and kinds of tumors is had significant curative effect.

Caulis Spatholobi property hardship, sweet, temperature.Return liver, kidney channel, enrich blood, invigorate blood circulation, collateral dredging.Be used for menoxenia, blood deficiency and yellow complexion, paralysis and numbness, rheumatic arthralgia relaxing muscles and tendons to promote blood circulation; Nourishing blood for regulating menstruation, supplementary Amplifications of the Compendium of Materia Medica carry it can cure numb hand and foot; Quadriplegia; Rheumatic arthralgia; The women has through uncomfortable; Dysmenorrhea.Be the good medicine of enriching blood simply and invigorating blood circulation.

Herba Taraxaci is a Chinese medicine commonly used simply, and its medical value is loaded various medical books early.Its all herbal medicine contains compositions such as taraxasterol, taraxerol, taraxacin, caffeic acid, choline, inulin.The flat sweet and slightly bitter taste of property.But heat-clearing and toxic substances removing, dispersing swelling and dissipating binds.Compendium of Material Medica record: " Detoxicating food-poisoning, the gas that stagnates that looses, the heat clearing away poison, the relieving dyspepsia poison, disappear dislike swollen, tuberculosis, furuncle is swollen ".Herba Taraxaci is hidden sweet flat, and its property is nontoxic.When being goes into stomach into liver, the key medicine of analgesic removing heat from blood toxin expelling.

Rhizoma Atractylodis Macrocephalae bitter in the mouth, sweet, temperature.Return spleen, stomach warp.Cure mainly invigorating the spleen and benefiting QI, the dampness diuretic, hidroschesis, antiabortive.Be used for insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.The Rhizoma Atractylodis Macrocephalae has cytotoxicity to oncocyte, can reduce the rate of increase of oncocyte, lowers the aggressive of tumor tissue, improves the ability of body antitumor reaction.Rhizoma Atractylodis Macrocephalae volatile oil has inhibitory action to mice ehrlich carcinoma, lymphosarcoma ascitic type, the esophageal carcinoma (Eca109), sarcoma 180 etc.Atractylodes lactone B lumbar injection is to the murine sarcoma people.Remarkable inhibitory action is also arranged." property of medicine opinion " carries it: monarch, and sweet in the mouth, suffering, nontoxic.Can main big migratory arthralgia, diarrhea due to disorder of qi for many years, trusted subordinate's distending pain, the broken dyspepsia that disappears, sputum is removed in appetizing, removes cold and heat, lets out under ending.Interarea light is pleased, and preserves youthful looks, and goes to deceive.The swelling of harnessing the river is full, tells vomiting, and cold type of pain in the abdomen is vomited and diarrhoea incessantly, and the insufficiency of stomach-QI cold-dysentery.

This antitumor and the preparation method that improves the Chinese medicine preparation of immunity comprise: the preparation method when pharmaceutical dosage form is capsule is made up of following steps:

Cutis Bufonis 2000g, Gekko Swinhonis Gekko Swinhonis 2000g is earlier through 95% above ethanol extraction 3 times, promptly use soak with ethanol, 80～85 ℃ of heat are extracted, and the time was respectively 2 hours, 1 hour, 1 hour, and the weight ratio of used ethanol and Cutis Bufonis and Gekko Swinhonis Gekko Swinhonis is respectively: be for the first time 10 times of amounts, the second time are 6 times of amounts, be 6 times of amounts for the third time, merge the ethanol extract after the immersion three times, reclaim ethanol then, being concentrated into relative density is 1.06, the medicinal liquid stand for standby use after concentrating; Residue and other drug merge according to proportioning of the present invention, water is carried 3 times, be that decocting boils, 80～100 ℃, time were respectively 2 hours, 1.5 hours, 1 hour, the weight ratio of institute's water and residue and other drug gross weight is respectively: for the first time be 10 times of amounts, the second time are 8 times of amounts, be 6 times of amounts for the third time, the water extract that extracts three times merges, and concentrates (being concentrated into relative density is 1.08); With water extract and the merging of ethanol concentrated medicament, filtration, spray drying, granulation, encapsulated again.

The preparation method of powder Chinese patent medicine of the present invention comprises:

With Radix Ginseng 3000g, Radix Codonopsis 3000g, Radix Astragali 3000g, Radix Angelicae Sinensis 3000g, Radix Tripterygii Wilfordii 300g, Radix Fissistigmatis Glaucescentis 3000g, Grifola frondosa 3000g, Radix Polygoni Multiflori 3000g, Caulis Spatholobi 3000g, Herba Taraxaci 3000g part, Cutis Bufonis 2000g, Gekko Swinhonis Gekko Swinhonis 2000g, Flos Carthami 3000g, Fructus Lycii 3000g, Cortex Cinnamomi 3000g, Hericium erinaceus (Bull. Ex Fr.) Pers. 2000g, Rhizoma Atractylodis Macrocephalae 3000g, Resina garciniae 3000g; Add water and soaked 45 minutes for 20 liters, heated and boiled 35 minutes is filtered filtrate for later use; Filtering residue adds water and heats for the second time, boils 35 minutes, filters filtrate for later use; Filtering residue adds water again, and heated and boiled is 45 minutes for the third time, filters; Three filtrates are lumped together, and heating is concentrated into pasty state, puts into 80 ℃ of oven dry of baking oven postcooling, grinds to form fine-powdered; The powder Chinese patent medicine, convert warm boiled water, one day twice.

Medicaments preparation method of the present invention can also be following steps:

Described component is mixed by proportioning, drop into pulverizer and be ground into fine powder, after sieving, puts into fine powder the acid and alkali-resistance infusion kettle, at normal temperatures, flooded 15～30 days with ethanol, liquid and medicinal residues that dipping is good carry out squeeze and filter, get filtrate after the separation, the filtrate heating is concentrated into pasty state, puts into the oven for drying postcooling, grind to form fine-powdered; The powder Chinese patent medicine, convert warm boiled water, can one day twice.

This Chinese medicine preparation kidney tonifying tonify deficiency, nourishing blood and promoting blood circulation, treating both the principal and secondary aspects of a disease improves immunity of human body itself, nervous system regulation, the activating blood circulation to dissipate blood stasis eliminating stagnation can effectively suppress tumor growth, and with low cost, reparation technology is simple and easy to do.The present invention adopts the Chinese crude drug of the different property of medicine, has carried out the science compatibility, can reach ideal therapeutic effect, and safety, can alleviate the sufferer misery, improves patient's quality of life.The present invention is easy to use, selects for use medical material cheap, and manufacture method is simple, can create good social and be worth and economic interests.To improving pain that tumor body compressing causes and hemorrhagely having a good and clinical curative effect, and general situation such as the spirit, appetite, sleep etc. of obviously improving the patient, and side effect is little, treatment safety, convenient, can palliate the agonizing sufferings, prolong life, especially remarkable to the quality of life effect that improves patients with advanced cancer.Simultaneously this medicine can also with the radiotherapy of various cancers, chemotherapy in be used, have heightening the effect of a treatment, alleviate the effect of side effect.To not accepting the patient with advanced cancer of radiotherapy, chemotherapy, operative treatment, this medicine is ideal selection.

Pharmacology's toxicity test

1. skin irritation test

Getting rabbit and shave hair, is example with medicament powder of the present invention, induces and excite contact test, viewing test rabbit after 24 hours and 48 hours, and all loseing skin has phenomenons such as erythema and edema, with the negative control group zero difference.The result shows that this patch is bordering on zero to dermoreaction intensity, does not promptly have skin allergic reaction.

2. drug accumulation toxicity test report

Test method: select 20 healthy mices for use, female, male each 10, dosage designs per 5 days and is first phase, each issue dosage is respectively 0.10LD50,0.15LD50,0.22LD50,0.34LD50,0.50LD50, and the LD50 female, male mice of this sample is 5000m part/k part BW (five dosage be 500,750,1100,1700,2500m part/k part BW).Weighed once in per 5 days, and adjusted dosage, press 0.1ml/10 part BW per os and irritate stomach.After 20 days, animal does not have death condition takes place, and off-test is tried thing after 20 days by ascending-dose, and female, buck does not all have death condition and takes place.

Long term toxicity test, with 40,20,10ml/kg (being equivalent to clinical plan 67,33,17 times with daily dose respectively) gavages 60 days for rat continuously, do not see the overt toxicity reaction, obvious pathological changes is not seen in main organs histological examinations such as the heart, liver, lung, kidney, adrenal gland.

3. acute toxicity test

Give the white mouse oral administration medicine supplying with 300 times of the clinical consumption per day of this product endo-medicine, observed 5.All animals are strong as a result deposits, and its activity, diet, hair, Excreta are no abnormal, do not see toxic reaction.The white mouse damaged skin is carried out irritation test, and not seeing has irritative response and other untoward reaction.

Toxicity test proves that this medicine is toxic side effect and untoward reaction not, and clinical practice is safe and reliable.

Pharmacodynamics test

1, animal and tumor strain: ♀ NIH mice (18～20) g, ♂ ICR mice (18～20) g.

Tumor strain: murine sarcoma (S180), EAC solid tumor.Method: set up Mice with Spleen model Radix Et Rhizoma Rhei Natrii Sulfas by the preparation in 4: 1 of crude drug weight.Decoct contains crude drug 1.0/gml.Give mouse stomach 0.3ml every day, continued for 1 week, matched group is irritated stomach equivalent normal saline.

Next day is inoculated the tumor strain in modelling (be mice occurs that big loose stool approaches, is slow in action, hair color tarnish etc.) back.Getting the back 9 days kind Mus of inoculation of going down to posterity, peeling off the tumor piece under the aseptic condition, sterile saline is made homogenate at 1: 3, transfers to contain oncocyte 6 * 107/ml again, and it is subcutaneous to be inoculated in mice with spleen deficiency right side axillary fossa, every Mus 0.2ml; EAC cancer (solid type) 5 * 106/ml oncocyte, the right Pericarpium Arecae of every Mus is inoculation 0.2ml down.All expect blue dyeing before the above tumor kind inoculation, meter viable count 〉=90% with 0.2%.

2, experiment grouping

Inoculate next day, mice is divided into 3 groups at random, 10 every group, every day, intraperitoneal administration was 1 time, continuous 10 days.1 group of perfusion normal saline; 2 groups of perfusion injection 12ml/kg of the present invention; 3 groups of Perfusion CT X (cytoxan) 20mg/kg.Below all be diluted to 0.4ml with normal saline.Detect the index inhibition rate of tumor growth: put to death all animals next day after the drug withdrawal, strip the tumor piece, weigh, calculate tumour inhibiting rate.Inhibition rate of tumor growth=(treatment group tumor weight-matched group tumor is heavy)/matched group tumor heavy * 100%.The result shows that the present invention has tangible neoplasm growth, and suppression ratio is up to 88%.

Embodiment 1: Mrs Qin, and 41 years old, suffered from breast cancer in 2004, shift pulmonary carcinoma behind the excision, carry out the chemicotherapy treatment for a long time, because dealed with medicine went, immunity is seriously low, leukocyte count has only more than 2000 for many years, and the people also is unable to leave the bed throughout the year, and is very painful.Use following Drug therapy:

Radix Ginseng 15g, Radix Tripterygii Wilfordii 5g, Radix Codonopsis 15g, Radix Astragali 15g, Radix Angelicae Sinensis 15g, Radix Fissistigmatis Glaucescentis 20g, Grifola frondosa 20g, Radix Polygoni Multiflori 15g, Caulis Spatholobi 15g, Herba Taraxaci 15g, Cutis Bufonis 15g, Gekko Swinhonis Gekko Swinhonis 15g, Flos Carthami 20g, Fructus Lycii 15g, Cortex Cinnamomi 15g, Hericium erinaceus (Bull. Ex Fr.) Pers. 15g, Rhizoma Atractylodis Macrocephalae 15g, Resina garciniae 15g.

Fry in shallow oil decoction and take, 1 dose of every day, decocting is obeyed at twice, and per 7 days is a course of treatment.Take that spirit takes a turn for the better after 3 courses of treatment, skeleton pain disappears, and can walk after taking 8 courses of treatment with descending, take after 12 courses of treatment can be independently about the 6th buildings, take about 30 courses of treatment after leukocyte return to about 6000, heartilyly started working work now.

Embodiment 2: Mrs Shen, 55 years old, a swollen thing was found in breast top, patient in April, 2005 left side, is acupuncture sample pain, get biopsy in hospital June in the same year, turn out to be left milk duct infiltrating carcinoma, radical correction at once, in August, 2005, the patient finds that there is lump protuberance at right-hand cutout parasternal place, color of the leather is not red, does not also have pain, in the same year by the end of November to certain tumour hospital's diagnosis and treatment.Checked at that time that patient left side parasternal had a swollen object height to go out skin, about 3 * 5 centimetres, the thoracic wall diabrosis.After appeasing radiotherapy, the nest lymph node disappears on the left clavicle, and fibrosis appears in left front skin, about 5 * 5 centimetres of the moist decortication of left thoracic wall district, in about 2 * 2 centimetres of sizes of a ulcer surface are arranged, lay one's hand on and about 1.5 square centimeters an of lymph node right oxter, through failing to respond to any medical treatment.Satisfy to my institute's prescription on individual diagnosis.Patient's readme, whenever to fever in the afternoon, left thoracic wall ulcer surface is paroxysmal pain over nearly 2 years, the whole body sweating was difficult to stand when pain was acute, behind the clothes analgesic, pain is ended, the recurrence of overtime pain, the inboard swelling of left hand arm, the left upper extremity limitation of activity influences daily life, and diet descends, the xerostomia pharyngalgia, it is not good enough to sleep, and the urine red complexion is hard and dry.It is impractical to inspect patient's face: the dim complexion nothing, hectically flushed cheeks, the left side thoracic wall face of festering reaches 6 * 6 * 1.2 centimetres, no secretions, slough is stiff dark all around, and the presternum left border damages darkish complexion, 3rd, the 2 costicartilage necrosis blackout that fractures, be splayed approximately, visible heart and trunk pollex, the fibrosis of skin of left front.The Chest X-rays feminine gender, the liver function no abnormality seen.The red no body fluid of thin lingual fur matter, the thin string of pulse condition, heavily by the power deficiency, the Chinese medical discrimination patient consumes due to the impairment of YIN liquid by accumulateing in the pyretic toxicity, uses following Drug therapy:

Radix Ginseng 30g, Radix Tripterygii Wilfordii 7g, Radix Codonopsis 30g, Radix Astragali 30g, Radix Angelicae Sinensis 30g, Radix Fissistigmatis Glaucescentis 30g, Grifola frondosa 30g, Radix Polygoni Multiflori 30g, Caulis Spatholobi 30g, Herba Taraxaci 30g, Cutis Bufonis 20g, Gekko Swinhonis Gekko Swinhonis 20g, Flos Carthami 30g, Fructus Lycii 30g, Cortex Cinnamomi 30g, Hericium erinaceus (Bull. Ex Fr.) Pers. 20g, Rhizoma Atractylodis Macrocephalae 30g, Resina garciniae 30g.

After taking four courses of treatment, patient left side thoracic wall rotten position secretions transfers bonum et laudabile pus liquid to by the clear rare sample pus of canescence, its skin ulcer face obviously dwindles, and the cambium surfacing is bright and clean, forms cicatrix, only at residual black necrotic tissue two fritters of presternum left border, a spot of sticky yellow pus secretion is arranged, have a dull ache sometimes, idol has low grade fever, check sees that the upper left edge of presternum has one 0.2 * 0.4 * 0.1 centimetre of slough to come off voluntarily, does not see hemorrhage after taking 3 courses of treatment again.Other its these improvements of symptom.Menstruation this time also comes at the appointed time, and red menses is not seen piece, and lower abdomen is not bitterly.Defence clothes are after May again, symptom complete obiteration, breast portion palpation no abnormality seen, ultrasound diagnosis, right breast portion no abnormality seen.Follow up a case by regular visits to not recurrence in 1 year.

Embodiment 3: Zheng, man, 42 years old.The patient finds nasal bleeding in March, 2002, and time is sent out when healing, and December 18 days is in hospital's pathologic finding diagnosis simultaneously: nasopharynx hangs down differentiated squamous-cell carcinomas.Disease is seen: nasal obstruction, and headache, vision weakens, xerostomia, tinnitus, yellowish fur, slippery and rapid pulse.Look into the about egg size of cervical lymph node enlargement, matter is hard, and is movable poor.Card belongs to: insufficiency of lung-QI, the evil invasion and attack of poison, qi depression to blood stasis, phlegm-damp cohesion.Control suitable: dispersing the stagnated live-QI to relieve the stagnation of QI, clearing away heat-fire, dehumidifying is reduced phlegm.Use following prescription to cure:

Radix Ginseng 25g, Radix Tripterygii Wilfordii 5g, Radix Codonopsis 15g, Radix Astragali 15g, Radix Angelicae Sinensis 15g, Radix Fissistigmatis Glaucescentis 25g, Grifola frondosa 15g, Radix Polygoni Multiflori 25g, Caulis Spatholobi 25g, Herba Taraxaci 25g, Cutis Bufonis 15g, Gekko Swinhonis Gekko Swinhonis 10g, Flos Carthami 15g, Fructus Lycii 25g, Cortex Cinnamomi 15g, Hericium erinaceus (Bull. Ex Fr.) Pers. 20g, Rhizoma Atractylodis Macrocephalae 25g, Resina garciniae 15g.

Be decocted in water for oral dose 15 doses.Cooperate 60 cobalt therapies simultaneously, every day 7GY, totally 5600 rads.Two examine (on February 7th, 20033): cervical lymph node obviously dwindles, and the headache nose bleeding disappears, but still nasal obstruction, nasal mucus is thick, tinnitus, and xerostomia, thick fur is greasy, poor appetite.Continue to take four courses of treatment of the present invention, and cooperate radiotherapy.Three examine (on June 8th, 2003): medicine is after check nasopharynx part tumor disappears, and cervical lymph node does not touch, and it is good that health is recovered.Again with five courses of treatment of prodrug, to consolidate it.JIUYUE was followed up a case by regular visits on the 3rd in 2008, and nearly so far 5 years of patient treatment, clinical announcement are more.

Embodiment 4: Pan, and the man, 39 years old, on November 19th, 2005, its wife examined out of admiration for a famous person.The lasting low grade fever that occurs unknown cause the year before is a malignant lymphoma through hospital diagnosis, with " COTP " scheme and " COHP " scheme, 6 courses of treatment of chemotherapy, poor effect, change the Shanghai hospitalize October 4 the same year over to, is diagnosed as non_hodgkin lymphoma companion pulmonary infection.And with new departure of international new drug such as CTX, taxol combination, 3 courses of treatment of chemotherapy, curative effect is dissatisfied, hospital's notice of being critically ill for twice time, leave hospital on November 12nd, 2005, its wife tells in generation: several Semen Viciae fabae size lymph nodes of left neck, and matter is hard, movable poor, the big enlarged lymph node in oxter, groin Semen arachidis hypogaeae several, the hard inertia of matter, the enlargement of companion's retroperitoneal lymph node, head pain is desired to split, heating a few days more than 40 ℃, companion's cough, expectorant glues yellow skin, and difficulty is coughed up, indigestion and loss of appetite, insomnia, constipation.This is a depression of liver-QI, the resembling of strongly fragrant heat-transformation impairing the lung network of a specified duration.Use following prescription treatment:

Radix Ginseng 15g, Radix Tripterygii Wilfordii 5g, Radix Codonopsis 15g, Radix Astragali 20g, Radix Angelicae Sinensis 20g, Radix Fissistigmatis Glaucescentis 20g, Grifola frondosa 20g, Radix Polygoni Multiflori 15g, Caulis Spatholobi 15g, Herba Taraxaci 25g, Cutis Bufonis 15g, Gekko Swinhonis Gekko Swinhonis 15g, Flos Carthami 20g, Fructus Lycii 15g, Cortex Cinnamomi 15g, Hericium erinaceus (Bull. Ex Fr.) Pers. 15g, Rhizoma Atractylodis Macrocephalae 20g, Resina garciniae 15g.

Serve on for ten courses of treatment.Serve on 2 months.Two examine: heating is moved back, pain relief, and all diseases subtract, and spirit is good, comes banyan further consultation, yellow fur, rolling pulse in person by train.This ties mutually for phlegm-fire, and irritability stasis still with top medicine plus-minus, took for 8 courses of treatment.After when summing up material, follow up a case by regular visits to the patient, medicine takes the disappearance of all diseases, if the people is ordinary person, healthy living.

The present invention is right, and for various tumors and alimentary tract cancer, esophageal carcinoma, carcinoma of gastric cardia, gastric cancer, hepatocarcinoma, colorectal cancer, pulmonary carcinoma, nasopharyngeal carcinoma, breast carcinoma, cervical cancer etc. all have significant curative effect, especially hepatocarcinoma, cirrhotic ascites, pulmonary carcinoma are had positive effect.Routine patient's clinical observation surplus 120, effective percentage 91%, improvement rate 88%, and tried the patient and be tumor, cancer patient, diet difficulty, the health extremely feeble, part cancer patient's many places diffusion promptly begins QI movement being in harmonious way with a couple of days behind this preparation, QI and blood and accent, reach treating the poisonous disease with poisonous drugs, removing obstruction in the collateral to relieve pain is controlled its mark, blocking-up tumor-blood-vessel growth, human body immunity improving power are improved the life quality of tumor patient greatly with Zhi Qiben, part patient fully recovers, shows unprecedented therapeutic effect.

Claims (10)

1, the Chinese medicine preparation of a kind of antitumor and enhancing immunity, it is characterized in that the ratio of weight and number of various components is in the described Chinese medicine preparation: 10～30 parts of Radix Ginsengs, 2～7 parts of Radix Tripterygii Wilfordiis, 10～30 parts of Radix Codonopsis, 10～30 parts of the Radixs Astragali, 10～30 parts of Radix Angelicae Sinensis, 10～30 parts of Radix Fissistigmatis Glaucescentiss, 10～30 parts of Grifola frondosa, 10～30 parts of Radix Polygoni Multiflori, 10～30 parts of Caulis Spatholobis, 10～30 parts of Herba Taraxacis, 10～20 parts of Cutis Bufonis, 10～20 parts of Gekko Swinhonis Gekko Swinhonis, 10～30 parts on Flos Carthami, 10～30 parts of Fructus Lycii, 10～30 parts of Cortex Cinnamomis, 10～20 parts of Hericium erinaceus (Bull. Ex Fr.) Pers., 10～30 parts of the Rhizoma Atractylodis Macrocephalaes, 10～30 parts of Resina garciniaes.

2, Chinese medicine preparation according to described antitumor of claim 1 and enhancing immunity, it is characterized in that the ratio of weight and number of various components is in the described Chinese medicine preparation: 10～15 parts of Radix Ginsengs, 3～5 parts of Radix Tripterygii Wilfordiis, 10～15 parts of Radix Codonopsis, 10～15 parts of the Radixs Astragali, 10～15 parts of Radix Angelicae Sinensis, 10～20 parts of Radix Fissistigmatis Glaucescentiss, 10～20 parts of Grifola frondosa, 10～15 parts of Radix Polygoni Multiflori, 10～15 parts of Caulis Spatholobis, 10～15 parts of Herba Taraxacis, 10～15 parts of Cutis Bufonis, 10～15 parts of Gekko Swinhonis Gekko Swinhonis, 10～20 parts on Flos Carthami, 10～15 parts of Fructus Lycii, 10～15 parts of Cortex Cinnamomis, 10～15 parts of Hericium erinaceus (Bull. Ex Fr.) Pers., 10～15 parts of the Rhizoma Atractylodis Macrocephalaes, 10～15 parts of Resina garciniaes.

3, Chinese medicine preparation according to described antitumor of claim 1 and enhancing immunity, it is characterized in that the ratio of weight and number of various components is in the described Chinese medicine preparation: 10～20 parts of Radix Ginsengs, 4～6 parts of Radix Tripterygii Wilfordiis, 10～20 parts of Radix Codonopsis, 10～20 parts of the Radixs Astragali, 10～20 parts of Radix Angelicae Sinensis, 10～15 parts of Radix Fissistigmatis Glaucescentiss, 10～15 parts of Grifola frondosa, 10～20 parts of Radix Polygoni Multiflori, 10～20 parts of Caulis Spatholobis, 10～15 parts of Herba Taraxacis, 10～15 parts of Cutis Bufonis, 10～15 parts of Gekko Swinhonis Gekko Swinhonis, 10～15 parts on Flos Carthami, 10～20 parts of Fructus Lycii, 10～15 parts of Cortex Cinnamomis, 10～15 parts of Hericium erinaceus (Bull. Ex Fr.) Pers., 10～20 parts of the Rhizoma Atractylodis Macrocephalaes, 10～20 parts of Resina garciniaes.

4, Chinese medicine preparation according to described antitumor of claim 1 and enhancing immunity, it is characterized in that the ratio of weight and number of various components is in the described Chinese medicine preparation: 15～25 parts of Radix Ginsengs, 3～7 parts of Radix Tripterygii Wilfordiis, 15～25 parts of Radix Codonopsis, 15～25 parts of the Radixs Astragali, 15～25 parts of Radix Angelicae Sinensis, 10～25 parts of Radix Fissistigmatis Glaucescentiss, 15～25 parts of Grifola frondosa, 10～25 parts of Radix Polygoni Multiflori, 10～25 parts of Caulis Spatholobis, 10～25 parts of Herba Taraxacis, 10～15 parts of Cutis Bufonis, 10～15 parts of Gekko Swinhonis Gekko Swinhonis, 15～25 parts on Flos Carthami, 15～25 parts of Fructus Lycii, 15～25 parts of Cortex Cinnamomis, 10～20 parts of Hericium erinaceus (Bull. Ex Fr.) Pers., 15～25 parts of the Rhizoma Atractylodis Macrocephalaes, 15～25 parts of Resina garciniaes.

According to the Chinese medicine preparation of described antitumor of claim 1 and enhancing immunity, it is characterized in that 5, described Chinese medicine preparation is fried in shallow oil decoction in use and taken, 1 dose of every day, decocting is obeyed at twice, and per 7 days is a course of treatment.

According to the Chinese medicine preparation of described antitumor of claim 1 and enhancing immunity, it is characterized in that 6, the dosage form of described Chinese medicine preparation is: honey refining pill, hydration pill, capsule, oral liquid, granule, colloid, syrup or drop.

According to the Chinese medicine preparation of described antitumor of claim 1 and enhancing immunity, it is characterized in that 7, described pharmaceutical dosage form is tablet or powder, when taking, one day three times, per 7 days is a course of treatment.

8, the preparation method of the Chinese medicine preparation of a kind of antitumor according to claim 1 and enhancing immunity is characterized in that, described pharmaceutical dosage form is a capsule, and its preparation process comprises:

According to described portion rate with Cutis Bufonis and Gekko Swinhonis Gekko Swinhonis with 95% soak with ethanol three times, each soak time was respectively 2 hours, 1 hour, 1 hour; Each 80～85 ℃ of heat in back of soaking are extracted; The ratio of weight and number of used ethanol and Cutis Bufonis and Gekko Swinhonis Gekko Swinhonis is respectively: for the first time 10 times of amounts, the second time 6 times of amounts, 6 times of amounts for the third time; Merge three times ethanol extract, be concentrated into relative density and be 1.06 concentrated solution, stand for standby use; Residue after the aforementioned extraction and other described components merge, and 80～100 ℃ of decoctings boil three times, and decocting time was respectively 2 hours, 1.5 hours, 1 hour; The ratio of weight and number of institute's water and residue and other component gross weights is respectively: for the first time 10 times of amounts, the second time 8 times of amounts, 6 times of amounts for the third time; Merge three times decoction liquor, be concentrated into relative density and be 1.08 concentrated solution; With decocting and concentrating liquid and the merging of ethanol concentrated solution, filtration, spray drying, granulation, encapsulated again.

9, the preparation method of the Chinese medicine preparation of a kind of antitumor according to claim 1 and enhancing immunity is characterized in that, described pharmaceutical dosage form is a powder, and its preparation process comprises:

Described component was soaked 30 minutes to 1 hour, and heating was boiled 30～40 minutes, filtered filtrate for later use; Filtering residue adds water and heats for the second time, boils 30～40 minutes, filters filtrate for later use; Filtering residue adds water again, and heated and boiled is 40～50 minutes for the third time, filters; Three filtrates are lumped together, and heating is concentrated into pasty state, puts into 80 ℃ in baking oven oven dry postcooling, grinds to form fine-powdered, the powder Chinese patent medicine.

10, the preparation method of the Chinese medicine preparation of a kind of antitumor according to claim 1 and enhancing immunity is characterized in that, described pharmaceutical dosage form is a powder, and its preparation comprises:

Described component is mixed by proportioning, drop into pulverizer and be ground into fine powder, put into the acid and alkali-resistance infusion kettle after fine powder sieves, at normal temperatures, flooded 15～30 days with ethanol is common, liquid and medicinal residues that dipping is good carry out squeeze and filter, get filtrate after the separation, the filtrate heating is concentrated into pasty state, put into the oven for drying postcooling, grind to form fine powder, the powder Chinese patent medicine.