CN104800457A - Hard lump-resolving agent for treating gastric cancer and preparation method - Google Patents

Abstract

The invention discloses a hard lump-resolving agent for treating gastric cancer and a preparation method. The hard lump-resolving agent is prepared by taking the following raw materials by weight part: 13 to 20 parts of cinnamon, 11 to 15 parts of flos caryophylli, 12 to 18 parts of corydalis tuber, 9 to 13 parts of patrinia heterophylla, 7 to 12 parts of cactuses, 9 to 14 parts of flos mume, 12 to 19 parts of codonopsis pilosula, 6 to 13 parts of cephalotaxus fortunei, 9 to 11 parts of water chestnut, 10 to 13 parts of Chinese actinidia roots, 12 to 17 parts of wahlenbergia marginata, 7 to 12 parts of rhizoma cimicifugae, 8 to 14 parts of lindernia crustacean, 7 to 11 parts of common tetragonia herbs, 9 to 15 parts of kelp, 6 to 14 parts of rhizoma pinellinae praeparata, 9 to 12 parts of fructus aurantii, 10 to 13 parts of ligusticum wallichii and 6 to 9 parts of concha arcae. The hard lump-resolving agent is free from risk, operative complications, pain of sequela, wound and side effect of chemoradiotherapy; the cancer is difficult to transfer and relapse; pure natural Chinese herbal medicines are taken as the main raw materials, so that the hard lump-resolving agent is environment-friendly and safe; the effects in counteracting toxic substances and strengthening the body resistance are both achieved; the capability of the whole body to prevent and resist against cancer can be improved by regulating the viscera channel physiological function; the anticancer immunity of a patient can be enhanced; the living quality and the survival rate are increased.

Description

A kind of hard masses softening and resolving agent and method for making for the treatment of gastric cancer

Technical field

The present invention relates to traditional Chinese medicine field, particularly relate to a kind of hard masses softening and resolving agent and method for making for the treatment of gastric cancer.

Background technology

Gastric cancer ranks first in the various malignant tumor of China, sends out well the age more than 50 years old, and the ratio of men and women's sickness rate is 2:1.The cause of disease of gastric cancer is comparatively assorted, and the traditional Chinese medical science is thought, incidence gastric cancer is because have intemperance of taking food, and be worried excessively, spleen injury, depressed expectorant are solidifying.The pathogenesis that Ming Dynasty's Zhang Jingyue proposes this disease for " eat the anti-person's of going out yang deficiency can not change; ... the person of descending of must not eat can not go with depressed ", warming YANG and thin gas are advocated in treatment accordingly, say in the work such as Qing Dynasty Wu Qian Golden Mirror of Medicine miscellaneous diseases heart method gist: " three positive accumulation of heats; meaning stomach, small intestinal, large intestine three mansion accumulation of heat do not fall apart, and consumption of body fluid by heat also.Three mansion body fluid were both hindered, and three are naturally withered, and the road of water paddy discrepancys must not circulate, and cardia dries up, then the road including water paddy in is narrow, thus eat can not under, for dysphagia also.Pylorus dries up, then it is narrow to release the road of corruption, thus eat counter go out for regurgitation of food from the stomach also.With the passing of time two cards are lingered on, then the road of large intestine conduction is narrow, therefore soul Men Ziying is dry is puckeryly difficult to walk also.Chest pain is as thorn, and gastral cavilty wound also; Just as sheep stool, body fluid is also withered; Saliva hematemesis, blood is not all right, and all dead card also." in a word, the traditional Chinese medical science is thought when interior-deficiency spleen injury, the silt of the stagnation of QI, food stagnation, expectorant, accumulation of heat etc. form gastric tumor lump and show as different pattern of syndrome.

Syndrome Differentiation of Traditional Chinese Medicine and treatment: (1) incoordination between the liver and stomach: gastral cavilty distension, belch is done frequently, and bitter taste is vexed, pain string two side of body, and diet enters less or vomits regurgitation, thin white fur of tongue or BOHUANG, stringy and thready pulse, and controlling should dispersing the stagnated liver-QI for regulating the stomach.(2) Deficiency and coldness of spleen and stomach: epigastric distending pain, pain relieved by pressing is temperature just, the cool Mental fatigue of limb, or loose stool edema, or vomiting out in the morning what eaten at last night, eating in the morning but vomiting out in the evening, light red tongue and fat, tooth mark, white, slippery and moist fur are greasy, deep-thready pulse is stagnant, and controlling should spleen invigorating warming middle-JIAO.(3) damp and hot silt poison: gastral cavilty twinge, scorching hot regurgitation, postprandial pain weight, gastral cavity abdomen tenderness, epigastric oppression block, or have hematemesis to have blood in stool, or eat and namely tell, or eat and prolongedly still to spue again, the tip of the tongue is dark violet or have petechiae, yellow and greasy fur, stringy and rolling pulse or stringy and rapid pulse, controls and should clearing away heat and eliminating dampness, removing toxic substances to dispel silt.(4) QI and blood is two loses: face is grey simple and unadorned, face face edema due to deficiency, coldness of the body cold syndrome of the stomach, and malaise, shortness of breath and palpitation, have a dizzy spell, fidgets due to deficiency is insomnia, inappetence, and body is won thin, and upper abdomen enclosed mass is obvious, and pale tongue is fat, white fur, deficient and thready pulse is unable, counts accurately or empty large, and controlling should qi and blood tonifying, with time delay day.Chinese medical discrimination type is sometimes not simple, sometimes have and add assorted and double disease, in general, liver-stomach disharmony type is more common in I, II phase patient, spleen-stomach deficiency-cold sees II, III phase patient, and damp and hot silt poison type sees II, III, IV phase patient, and phase patient in late period III or IV is then more common in by the two type that loses of QI and blood, certainly press TNM by stages, dialectical type shows as that amphitypy is double sees sometimes.Postoperative recurrence or have the patients with terminal of transfer then in the majority with the two person that thanks to do not have both at the same time of damp and hot silt poison and QI and blood, i.e. simulataneous insufficiency and excessive.The pattern of syndrome caused because of iatrogenic during the modern treatment of gastric cancer is then more complicated various, have performance deficiency of both QI and YIN, have performance incoordination between the spleen and stomach, also has and shows as syndrome of blood stasis due to qi deficiency, when with tcm treatment according to syndrome differentiation.

Application publication number CN 104435251 A(application number 201410646162.2) Chinese patent literature disclose a kind of medicine for the treatment of gastric cancer, be made up of following crude drug: Radix Salviae Miltiorrhizae 15 grams, the Radix Astragali 15 grams, Radix Angelicae Sinensis 9 grams, Cortex Magnoliae Officinalis 15 grams, Endoconcha Sepiae 15 grams, the Radix Aucklandiae 9 grams, Scorpio 3,12 grams, Semen Persicae, Cordyceps 6 grams, Flos Lonicerae 12 grams, Herba Artemisiae Scopariae 15 grams, Herba Lysimachiae 12 grams, Realgar 0.6 gram, 15 grams, Poria, Pericarpium Citri Reticulatae 12 grams, Scolopendra 5, CATHARSIUS 15 grams, 12 grams, Radix Glycyrrhizae.If gastric qi does not freely add Rhizoma Pinelliae 9 grams, Caulis Bambusae In Taenia 12 grams, Fructus Aurantii Immaturus 12 grams; Weakness of the spleen and stomach adds the Rhizoma Atractylodis Macrocephalae 12 grams, Rhizoma Dioscoreae 20 grams, Semen Coicis 12 grams.Application publication number CN 104306802 A(application number 201410550620.2) Chinese patent literature disclose one and treat gastric cancer Chinese medicine Western medicine compatibility agent.Wherein Chinese drug-treated group is made up of the raw material of following weight proportioning: Radix Ginseng 10g-20g, Poria 15g, Pericarpium Citri Reticulatae 15-20g, Scorpio 10-20g, the Radix Astragali 60-70g, Scolopendra 2, Semen Coicis 30-40g, Fructus Crataegi 20-30g, western medicine component is: aspirin 3-4, phenobarbital 3-4.Be condensed into medicine juice 100ml by after above-mentioned Chinese medicine decocting, western medicine tablet grind into powder be dissolved in above-mentioned concentrated medicine juice and get final product.

At present, the Therapeutic Method of gastric cancer mainly contains surgical resection therapy, radiation and chemotherapy.Can Rapid tumor cell by surgical resection therapy, instant effect, but it cannot eradicate tumor cells tissue, very easily shifts, recurs, cause diffusion and the transfer of tumor cell, making patients's state of an illness; Chemicotherapy can local or the load of whole body ameliorate tumor cell, instant effect, but it cannot eradicate tumor cells tissue, easy transfer, recurrence, whole body toxic and side effects is large, very easily produces the symptoms such as Nausea and vomiting, alopecia, inappetence, causes immune function of human body to damage.The target of operation, radiotherapy and chemotherapy is be conceived to tumors destroyed focus and cancerous cell completely, and has impact to the anti-cancer ability of body and function, often brings obvious untoward reaction to patient, has damaged the healthy energy of human body.

Summary of the invention

For the deficiencies in the prior art, the object of this invention is to provide a kind of hard masses softening and resolving agent and method for making for the treatment of gastric cancer.Devoid of risk of the present invention, without postoperative complication, the misery of sequela, hurtless measure, toxicity without chemicotherapy, not easily shift and recur, take pure natural Chinese herbal medicine as primary raw material, environmental protection, safety, counteracting toxic substances and righting are laid equal stress on, conditioning viscera meridians physiological function, can improve whole body to tumor defence and resistivity, strengthen the antitumor immune function of patient self, improve life quality and survival rate.

Technical scheme of the present invention is:

Treat a hard masses softening and resolving agent for gastric cancer, take off the primary raw material medicine stating weight proportion and be prepared from: Cortex Cinnamomi 13-20, Flos Caryophylli 11-15, Rhizoma Corydalis 12-18, Radix Patriniae heterophyllae 9-13, Radix et Caulis Opuntiae Dillenii 7-12, FLOS MUME 9-14, Radix Codonopsis 12-19, Folium et Ramulus Cephalotaxi 6-13, Pedicellus et Pericarpium Trapae 9-11, Radix Actinidiae Chinensis 10-13, Herba Wahlenbergiae 12-17, Rhizoma Cimicifugae 7-12, Herba Linderniae Crustaceae 8-14, Herba tetragoniae 7-11, Thallus Laminariae (Thallus Eckloniae) 9-15, Rhizoma Pinelliae Preparatum 6-14, Fructus Aurantii 9-12, Rhizoma Chuanxiong 10-13, Concha Arcae 6-9.

Treat a hard masses softening and resolving agent for gastric cancer, preferred scheme is, takes off the primary raw material medicine stating weight proportion and is prepared from: Cortex Cinnamomi 15-18, Flos Caryophylli 12-14, Rhizoma Corydalis 15-17, Radix Patriniae heterophyllae 10-12, Radix et Caulis Opuntiae Dillenii 9-11, FLOS MUME 10-12, Radix Codonopsis 14-17, Folium et Ramulus Cephalotaxi 8-11, Pedicellus et Pericarpium Trapae 9.5-10.5, Radix Actinidiae Chinensis 11-12.5, Herba Wahlenbergiae 13-15, Rhizoma Cimicifugae 8-10, Herba Linderniae Crustaceae 10-13, Herba tetragoniae 8-10, Thallus Laminariae (Thallus Eckloniae) 11-13, Rhizoma Pinelliae Preparatum 8-12, Fructus Aurantii 9.5-11, Rhizoma Chuanxiong 11-12, Concha Arcae 7-8.

Treat a hard masses softening and resolving agent for gastric cancer, the scheme be more preferably is, takes off the primary raw material medicine stating weight proportion and is prepared from: Cortex Cinnamomi 16, Flos Caryophylli 13, Rhizoma Corydalis 16, Radix Patriniae heterophyllae 11, Radix et Caulis Opuntiae Dillenii 10, FLOS MUME 11, Radix Codonopsis 16, Folium et Ramulus Cephalotaxi 10, Pedicellus et Pericarpium Trapae 10, Radix Actinidiae Chinensis 11.5, Herba Wahlenbergiae 14, Rhizoma Cimicifugae 9, Herba Linderniae Crustaceae 12, Herba tetragoniae 9, Thallus Laminariae (Thallus Eckloniae) 12, Rhizoma Pinelliae Preparatum 9, Fructus Aurantii 10, Rhizoma Chuanxiong 11.5, Concha Arcae 7.5.

Present invention also offers the aforementioned preparation method making pharmaceutically acceptable granule, tablet, capsule and pill.

The preparation method of described granule is:

(1) boiled by Pedicellus et Pericarpium Trapae and shell, be cut into grain of rice size, dry at the temperature of 45-55 DEG C (preferably dry at the temperature of 50 DEG C), dry 25-42 hour (preferably dry 36 hours), are ground into fine powder, cross No. six sieves;

(2) by all the other except Pedicellus et Pericarpium Trapae 18 taste crude drug pulverization respectively, No. six sieves are crossed;

(3) by step (1) and step (2) gained mix homogeneously, add the alcoholic solution (preferably adding the alcoholic solution that mass fraction is 65%) that mass fraction is 60%-70%, stir, to " hands is pinched agglomerating, namely faling apart of pressure ", 16-20 mesh sieve granulates (preferably granulating on 18 mesh sieves), make uniform granule, dry at the temperature of 50 DEG C-60 DEG C (preferably dry at the temperature of 55 DEG C), dry 3-5 hour (preferably dry 4 hours), granulate, sub-sieve, to obtain final product.

The preparation method of described tablet is:

(1) boiled by Pedicellus et Pericarpium Trapae and shell, be cut into grain of rice size, dry at the temperature of 45-55 DEG C (preferably dry at the temperature of 50 DEG C), dry 25-42 hour (preferably dry 36 hours), are ground into fine powder, cross No. five sieves;

(2) by all the other except Pedicellus et Pericarpium Trapae 18 taste crude drug pulverization respectively, No. five sieves are crossed;

(3) by step (1) and step (2) gained mix homogeneously, add the alcoholic solution (preferably adding the alcoholic solution that mass fraction is 65%) that mass fraction is 60%-70%, stir, to " hands is pinched agglomerating; namely faling apart of pressure ", 16-20 mesh sieve is granulated (preferably granulating on 18 mesh sieves), makes uniform granule, dry at the temperature of 50 DEG C-60 DEG C (preferably dry at the temperature of 55 DEG C), dry 3-5 hour (preferably dry 4 hours), tabletting, the heavy 0.5g of every sheet, to obtain final product.

The preparation method of described capsule is:

(1) boiled by Pedicellus et Pericarpium Trapae and shell, be cut into grain of rice size, dry at the temperature of 45-55 DEG C (preferably dry at the temperature of 50 DEG C), dry 25-42 hour (preferably dry 36 hours), are ground into fine powder, cross No. five sieves;

(2) by all the other except Pedicellus et Pericarpium Trapae 18 taste crude drug pulverization respectively, No. five sieves are crossed;

(3) by step (1) and step (2) gained mix homogeneously, add the alcoholic solution (preferably adding the alcoholic solution that mass fraction is 65%) that mass fraction is 60%-70%, stir, to " hands is pinched agglomerating, namely faling apart of pressure ", 16-20 mesh sieve granulates (preferably granulating on 18 mesh sieves), make uniform granule, dry at the temperature of 50 DEG C-60 DEG C (preferably dry at the temperature of 55 DEG C), dry 3-5 hour (preferably dry 4 hours), load zero capsule, every capsules is equipped with medicated powder 0.32g, by the capsule polishing in buffing machine installed, pressing plate, obtain.

The preparation method of described pill is:

(1) boiled by Pedicellus et Pericarpium Trapae and shell, be cut into grain of rice size, dry at the temperature of 45-55 DEG C (preferably dry at the temperature of 50 DEG C), dry 25-42 hour (preferably dry 36 hours), are ground into fine powder, cross No. five sieves;

(2) by all the other except Pedicellus et Pericarpium Trapae 18 taste crude drug pulverization respectively, No. five sieves are crossed;

(3) by step (1) and step (2) gained mix homogeneously, take mass fraction as the alcoholic solution pill of 75%, make the pill of the heavy 0.5g of every ball, gained pill is dry at the temperature of 55 DEG C, make water content control 9%, be taken out to and cool completely, to obtain final product.

The hard masses softening and resolving agent scientific formula products obtained therefrom taking convenience for the treatment of gastric cancer provided by the invention, to be easy to carry.In addition, excellent results of the present invention also shows:

1, devoid of risk, without postoperative complication, the misery of sequela, hurtless measure, toxicity without chemicotherapy;

2, take pure natural Chinese herbal medicine as primary raw material, environmental protection, safety;

3, preparation method is simple;

4, not easily shift and recur;

5, counteracting toxic substances and righting are laid equal stress on, conditioning viscera meridians physiological function, can improve whole body to tumor defence and resistivity;

6, the antitumor immune function of patient self can be strengthened, improve life quality and survival rate.

Detailed description of the invention

Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.

embodiment 1treat a hard masses softening and resolving agent for gastric cancer, the primary raw material medicine getting following weight parts is prepared from (every part is 300g): Cortex Cinnamomi 13 parts, Flos Caryophylli 11 parts, Rhizoma Corydalis 12 parts, Radix Patriniae heterophyllae 9 parts, Radix et Caulis Opuntiae Dillenii 7 parts, FLOS MUME 9 parts, Radix Codonopsis 12 parts, Folium et Ramulus Cephalotaxi 6 parts, Pedicellus et Pericarpium Trapae 9 parts, Radix Actinidiae Chinensis 10 parts, Herba Wahlenbergiae 12 parts, Rhizoma Cimicifugae 7 parts, Herba Linderniae Crustaceae 8 parts, Herba tetragoniae 7 parts, Thallus Laminariae (Thallus Eckloniae) 9 parts, Rhizoma Pinelliae Preparatum 6 parts, Fructus Aurantii 9 parts, Rhizoma Chuanxiong 10 parts, Concha Arcae 6 parts.

The preparation method of the hard masses softening and resolving agent granule of above-mentioned treatment gastric cancer is:

(1) Pedicellus et Pericarpium Trapae is boiled shell, be cut into grain of rice size, dry at the temperature of 45 DEG C, dry 25 hours, be ground into fine powder, cross No. six sieves;

(2) by all the other except Pedicellus et Pericarpium Trapae 18 taste crude drug pulverization respectively, No. six sieves are crossed;

(3) by step (1) and step (2) gained mix homogeneously, add the alcoholic solution that mass fraction is 60%, stir, to " hands is pinched agglomerating; namely faling apart of pressure ", 16 mesh sieves are granulated, makes uniform granule, dry at the temperature of 50 DEG C, dry 3 hours, granulate, sub-sieve, to obtain final product.

The instructions of taking of the hard masses softening and resolving agent granule of gained treatment gastric cancer of the present invention: three times on the one, each 12g, boiled water is taken after mixing it with water, and 4 weeks is a course for the treatment of.

embodiment 2treat a hard masses softening and resolving agent for gastric cancer, the primary raw material medicine getting following weight parts is prepared from (every part is 300g): Cortex Cinnamomi 20 parts, Flos Caryophylli 15 parts, Rhizoma Corydalis 18 parts, Radix Patriniae heterophyllae 13 parts, Radix et Caulis Opuntiae Dillenii 12 parts, FLOS MUME 14 parts, Radix Codonopsis 19 parts, Folium et Ramulus Cephalotaxi 13 parts, Pedicellus et Pericarpium Trapae 11 parts, Radix Actinidiae Chinensis 13 parts, Herba Wahlenbergiae 17 parts, Rhizoma Cimicifugae 12 parts, Herba Linderniae Crustaceae 14 parts, Herba tetragoniae 11 parts, Thallus Laminariae (Thallus Eckloniae) 15 parts, Rhizoma Pinelliae Preparatum 14 parts, Fructus Aurantii 12 parts, Rhizoma Chuanxiong 13 parts, Concha Arcae 9 parts.

The preparation method of the hard masses softening and resolving agent tablet of above-mentioned treatment gastric cancer is:

(1) Pedicellus et Pericarpium Trapae is boiled shell, be cut into grain of rice size, dry at the temperature of 50 DEG C, dry 36 hours, be ground into fine powder, cross No. five sieves;

(2) by all the other except Pedicellus et Pericarpium Trapae 18 taste crude drug pulverization respectively, No. five sieves are crossed;

(3) by step (1) and step (2) gained mix homogeneously, add the alcoholic solution that mass fraction is 65%, stir, to " hands is pinched agglomerating; namely faling apart of pressure ", 18 mesh sieves are granulated, makes uniform granule, dry at the temperature of 55 DEG C, dry 4 hours, tabletting, the heavy 0.5g of every sheet, to obtain final product.

model case one:section XX, man, 55 years old.Main suit: gastric cancer more than 1 year.After patient is diagnosed as gastric cancer before 1 year, do stomach large portion resection operation immediately, a course for the treatment of of postoperative chemotherapy.Weak curative effect and health is undesirable, is illustrated in December, 2007 by friend and examines for 3rd.Examine and see that conditions of patients is unstable, weak, be off one's feed, become thin, yellowish complexion, deep-thready pulse, red tongue.Take the hard masses softening and resolving agent tablet of the present embodiment gained treatment gastric cancer, three times on the one, each 2, warm water takes.Take two weeks, conditions of patients tends towards stability, and appetite increases, movable strong.Continue to take three months, check to hospital, do not find cancerous cell.Follow up a case by regular visits to so far, in order, all are normal for patient body.

embodiment 3treat a hard masses softening and resolving agent for gastric cancer, the primary raw material medicine getting following weight parts is prepared from (every part is 300g): Cortex Cinnamomi 15 parts, Flos Caryophylli 12 parts, Rhizoma Corydalis 15 parts, Radix Patriniae heterophyllae 10 parts, Radix et Caulis Opuntiae Dillenii 9 parts, FLOS MUME 10 parts, Radix Codonopsis 14 parts, Folium et Ramulus Cephalotaxi 8 parts, Pedicellus et Pericarpium Trapae 9.5 parts, Radix Actinidiae Chinensis 11 parts, Herba Wahlenbergiae 13 parts, Rhizoma Cimicifugae 8 parts, Herba Linderniae Crustaceae 10 parts, Herba tetragoniae 8 parts, Thallus Laminariae (Thallus Eckloniae) 11 parts, Rhizoma Pinelliae Preparatum 8 parts, Fructus Aurantii 9.5 parts, Rhizoma Chuanxiong 11 parts, Concha Arcae 7 parts.

The preparation method of the hard masses softening and resolving agent capsules agent of above-mentioned treatment gastric cancer is:

(1) Pedicellus et Pericarpium Trapae is boiled shell, be cut into grain of rice size, dry at the temperature of 50 DEG C, dry 36 hours, be ground into fine powder, cross No. five sieves;

(2) by all the other except Pedicellus et Pericarpium Trapae 18 taste crude drug pulverization respectively, No. five sieves are crossed;

(3) by step (1) and step (2) gained mix homogeneously, add the alcoholic solution that mass fraction is 65%, stir, to " hands is pinched agglomerating, namely faling apart of pressure ", 18 mesh sieves are granulated, make uniform granule, dry at the temperature of 55 DEG C, dry 4 hours, load zero capsule, every capsules is equipped with medicated powder 0.32g, by the capsule polishing in buffing machine installed, pressing plate, to obtain final product.

model case two:beam XX, female, 60 years old.Main suit: epigastrium is glutted, appetite declines, more than Nausea and vomiting half a year.Once arrived local hospital to go to a doctor, local hospital is diagnosed as through gastroscopy: stomach carcinoma of gastric cardia.Rear row " radical operation for carcinoma of stomach " postoperative pathological shows: " stomach cardia lesser curvature side, ulcer type mamillary tubular adenocarcinoma." postoperative through 4 courses for the treatment of of chemotherapy, patient body extremely feeble, rear termination chemotherapy.Come to go to a doctor on October 8th, 2007.Examine and see patient's shallow complexion, spiritlessness and weakness, progressive emaciation.Appetite stimulator, gastral cavity abdomen deficiency-distension, loose stool oliguria, pale tongue with thin fur, thready and weak pulse.Take the hard masses softening and resolving agent capsules agent of the present embodiment gained treatment gastric cancer, three times on the one, each 2, warm water takes.Take 1 month, symptom is clearly better.Continue to take 2 months, clinical symptoms all disappears.Check cancerous cell disappears, without transfer.Follow up a case by regular visits to so far without transfer and recurrence.

embodiment 4treat a hard masses softening and resolving agent for gastric cancer, the primary raw material medicine getting following weight parts is prepared from (every part is 300g): Cortex Cinnamomi 18 parts, Flos Caryophylli 14 parts, Rhizoma Corydalis 17 parts, Radix Patriniae heterophyllae 12 parts, Radix et Caulis Opuntiae Dillenii 11 parts, FLOS MUME 12 parts, Radix Codonopsis 17 parts, Folium et Ramulus Cephalotaxi 11 parts, Pedicellus et Pericarpium Trapae 10.5 parts, Radix Actinidiae Chinensis 12.5 parts, Herba Wahlenbergiae 15 parts, Rhizoma Cimicifugae 10 parts, Herba Linderniae Crustaceae 13 parts, Herba tetragoniae 10 parts, Thallus Laminariae (Thallus Eckloniae) 13 parts, Rhizoma Pinelliae Preparatum 12 parts, Fructus Aurantii 11 parts, Rhizoma Chuanxiong 12 parts, Concha Arcae 8 parts.

The preparation method of the hard masses softening and resolving agent pill of above-mentioned treatment gastric cancer is:

(1) Pedicellus et Pericarpium Trapae is boiled shell, be cut into grain of rice size, dry at the temperature of 50 DEG C, dry 36 hours, be ground into fine powder, cross No. five sieves;

(2) by all the other except Pedicellus et Pericarpium Trapae 18 taste crude drug pulverization respectively, No. five sieves are crossed;

(3) by step (1) and step (2) gained mix homogeneously, take mass fraction as the alcoholic solution pill of 75%, make the pill of the heavy 0.5g of every ball, gained pill is dry at the temperature of 55 DEG C, make water content control 9%, be taken out to and cool completely, to obtain final product.

model case three:yellow XX, man, 66 years old.Main suit: epigastrium pain, inappetence, becomes thin, more than the April that loses weight.Go to a doctor to local hospital, through barium meal and gastroscopy, and through pathological diagnosis be: gastric antrum portion adenocarcinoma .because patient age is large, can not perform the operation.By the agency of, examined on May 10th, 2008.Examine and see patient's epigastrium pain with tenderness, appetite is poor, body progressive emaciation, and stool blackout, purplish tongue, yellow fur is thick, thready and rolling pulse.Take the hard masses softening and resolving agent pill of the present embodiment gained treatment gastric cancer, three times on the one, each 5 balls, warm water takes.Take three weeks, epigastrium pain relief, appetite increases, and body weight increases to some extent, defecates pale yellow, dimly red tongue, yellow fur, thready and weak pulse.Continue to take 2 first quarter moons, above-mentioned symptom disappears completely, check, and cancerous cell disappears, without transfer.Follow up a case by regular visits to so far without transfer and recurrence.

embodiment 5treat a hard masses softening and resolving agent for gastric cancer, the primary raw material medicine getting following weight parts is prepared from (every part is 300g): Cortex Cinnamomi 16 parts, Flos Caryophylli 13 parts, Rhizoma Corydalis 16 parts, Radix Patriniae heterophyllae 11 parts, Radix et Caulis Opuntiae Dillenii 10 parts, FLOS MUME 11 parts, Radix Codonopsis 16 parts, Folium et Ramulus Cephalotaxi 10 parts, Pedicellus et Pericarpium Trapae 10 parts, Radix Actinidiae Chinensis 11.5 parts, Herba Wahlenbergiae 14 parts, Rhizoma Cimicifugae 9 parts, Herba Linderniae Crustaceae 12 parts, Herba tetragoniae 9 parts, Thallus Laminariae (Thallus Eckloniae) 12 parts, Rhizoma Pinelliae Preparatum 9 parts, Fructus Aurantii 10 parts, Rhizoma Chuanxiong 11.5 parts, Concha Arcae 7.5 parts.

The preparation method of the hard masses softening and resolving agent granule of above-mentioned treatment gastric cancer is:

(1) Pedicellus et Pericarpium Trapae is boiled shell, be cut into grain of rice size, dry at the temperature of 50 DEG C, dry 36 hours, be ground into fine powder, cross No. five sieves;

(2) by all the other except Pedicellus et Pericarpium Trapae 18 taste crude drug pulverization respectively, No. five sieves are crossed;

(3) by step (1) and step (2) gained mix homogeneously, add the alcoholic solution that mass fraction is 65%, stir, to " hands is pinched agglomerating; namely faling apart of pressure ", 18 mesh sieves are granulated, makes uniform granule, dry at the temperature of 55 DEG C, dry 4 hours, granulate, sub-sieve, to obtain final product.

The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:

Cortex Cinnamomi: base is former: be dried bark and the branch skin of canella Cortex Cinnamomi.The property of medicine: pungent; Sweet; Heat.Return kidney, spleen, the heart, Liver Channel.Function cures mainly: mend fire supporing yang, let the fire back to its origin, dispersing cold for relieving pain, warming the meridian and promoting blood circulation.Main insufficiency of kidney-YANG, gate of vitality's fire aversion to cold and cold limbs, soreness of the waist and knees, impotence and seminal emission, dysuria or frequency, to lose heart dyspnea with rapid and short breath, all cards of edema oliguria, decline of the fire from the gate of life, fire is Gui Yuan not, floating YANG, refusing yang, and heat in the upper and cold in the lower, flushed complexion cold foot, dizziness and tinnitus, dispute gruel is broken, spleen-kidney vacuity cold, coldness and pain in the epigastrium, decreased food intake loose stool, lumbago due to renal deficiency, arthralgia due to cold-dampnes, colic of cold type pain, cold womb is infertile, dysmenorrhea amenorrhea, the stagnant stomachache of the stasis of blood in puerperal, carbuncle of yin nature multiple abscess, or deficiency and coldness carbuncle and ulcer difficulty in discharging of pus, or do not hold back after bursting.

Flos Caryophylli: another name: hundred knots, feelings visitor, Syringa oblata Lindl., sub-Flos Caryophylli, clove tree, dismemberent perfume, male Flos Caryophylli, Flos Caryophylli.Base is former: be the alabastrum of dicotyledon medicine plant clove of myrtaceae.The property of medicine: pungent, temperature.Return spleen, stomach, lung, kidney channel.Function cures mainly: warming middle-JIAO to send down the adverse QI, reinforcing the kidney and supporting YANG.For Deficiency and coldness of spleen and stomach, singultus is vomitted, lack of appetite and vomiting, trusted subordinate's cold type of pain, impotence due to deficiency of the kidney.

Rhizoma Corydalis: base is former: be the tuber of papaveraceae plant corydalis.The property of medicine: pungent, bitter, temperature, nontoxic.Return liver, stomach, the heart, lung, spleen channel.Function cures mainly: invigorate blood circulation, and dissipating blood stasis is regulated the flow of vital energy, pain relieving.The all pains of main trusted subordinate's waist knee joint, menoxenia, lump in the abdomen, metrorrhagia, puerperal blood faints, lochiorrhea, traumatic injury.

Radix Patriniae heterophyllae: base is former: be the root of Valerianaceae plant Radix Patriniae Scabrae, Radix Patriniae Scabrae.The property of medicine: " Guangxi Chinese medicinal herbal ": " acrid in the mouth, warm in nature." " Guangxi Chinese medicinal herbal ": " enter the heart, liver two warp." function cures mainly: dampness leukorrhagia stopping, astringing to arrest bleeding, heat-clearing and toxic substances removing.Main leucorrhea with red and white discharge, metrorrhagia, dysentery, jaundice, malaria, acute appendicitis, sore swollen toxin, traumatic injury, cervical cancer, gastric cancer.For uterine erosion, early cervical carcinoma, leucorrhea, metrorrhagia, malaria.

Radix et Caulis Opuntiae Dillenii: base is former: be root and the stem of Cactaeous plants Radix et Caulis Opuntiae Dillenii and green Radix et Caulis Opuntiae Dillenii.The property of medicine: bitter; Cold in nature.GUIXIN, lung, stomach warp.Function cures mainly: promoting flow of QI and blood, heat-clearing and toxic substances removing, cooling blood for hemostasis, clearing away lung-heat to relieve cough.Main stomachache, mass in the abdomen, dysentery, laryngalgia, cough due to lung-heat, pulmonary tuberculosis is spat blood, and spits blood, hemorrhoidal bleeding, skin infection furuncle furuncle, acute mastitis, the cheek of itching, tinea disease, and snake bite and insect sting is scalded, cold injury.

FLOS MUME: base is former: be the dry flower of Armeniaca Mume of Rosaceae platymiscium FLOS MUME.The property of medicine: bitter, micro-sweet, flat.Function cures mainly: suppressing the hyperactive liver and easing the stomach.For distending pain in the chest and hypochondrium, stomachache, dyspepsia, neurasthenia.

Radix Codonopsis: base is former: be the dry root of Campanulaceae Radix Codonopsis, element flower Radix Codonopsis or radix codonpsis tangshen etc.Radix Codonopsis has containing sterols: hitodesterol, stigmasterol, hitodesterol-β-D-Glucose glycoside, stigmasterol-β-D-Glucose glycoside, α-Herba Spinaciae sterone, stigmasterone etc.Sugar and glycoside have: inulin, fructose, four kinds of heteropolysaccharide containing fructose.Syringin, β-D-Glucopyranose. hexanol glycoside, α-D-fructofuranose ethanol glycoside.Alkaloid and nitrogen containing component have: choline, normal-butyl allophanate, codopiloic acid, 5-hydroxy-2-hydroxymethylpyridine, nicotine.Volatile ingredient has: caproic acid, enanthic acid, sad, n-nonanoic acid, dodecoic acid, Azelaic Acid, tetradecylic acid, pentadecanoic acid, hexadecylic acid, stearic acid, octadecadienoic acid, 2,4-nonadienoic acids, Pentadecane, α-curcumene, n-heptadecane, n-octadecane, AI3-36122, positive 21 alkane, positive docosane, methyl myristate, pentadecanoic acid methyl ester, methyl palmitate, methyl stearate, octadecadienoic methyl, pinene, ethyl palmitate, methyl caprylate.Still containing triterpenes and other compositions: alnulin, Taraxeryl acetate, suberone; Atractyloide II, III; Syringic aldehyde, vanillic acid, 2-furan carboxylic esters, codonolactone, 5 hydroxymethyl furfural, 5-methoxyl group furfural.In addition, the also 17 seed amino acid property of medicine such as 14 kinds of inorganic elementss such as iron content, zinc, copper, manganese and aspartic acid, threonine, serine, glutamic acid: sweet, flat.Return spleen, lung meridian.Function cures mainly: invigorating the spleen and replenishing QI, spleen invigorating lung benefiting.For deficiency of the spleen and lung, cardiopalmus of breathing hard, anorexia and loose stool, dyspnea due to deficiency is coughed, and interior-heat is quenched one's thirst.

Folium et Ramulus Cephalotaxi: base is former: be the branch and leaf of cephalotaxaceae plant Folium et Ramulus Cephalotaxi.The property of medicine: bitter; Puckery; Cold in nature, poisonous.Function cures mainly: anticancer.Main malignant lymphoma, leukemia, pulmonary carcinoma, gastric cancer, esophageal carcinoma, rectal cancer etc.

Pedicellus et Pericarpium Trapae: another name: water caltrop, Shui Li, water caltrop reality, Pedicellus et Pericarpium Trapae, water Pedicellus et Pericarpium Trapae, Sha Jiao, Pedicellus et Pericarpium Trapae in fact, are the sarcocarp of the Pedicellus et Pericarpium Trapae, Trapa bicornis Osbeck, nothing hat Pedicellus et Pericarpium Trapae qualifying Pedicellus et Pericarpium Trapae etc. that Trapaceae plant man plants.The property of medicine: sweet in the mouth; Cool in nature.Return spleen, stomach warp.Function cures mainly: invigorating spleen and reinforcing stomach, and relieving restlessness order is thirsty, removing toxic substances.Main diarrhea due to hypofunction of the spleen, summer-heat excessive thirst, insobriety, dysentery.Pedicellus et Pericarpium Trapae contains abundant starch, protein, glucose, unsaturated fatty acid and multivitamin, as vitamin B1, B2, C, and the trace element such as carotene and calcium, phosphorus, ferrum.Ancients think eat Pedicellus et Pericarpium Trapae more can tonifying five ZANG-organs, except all kinds of diseases and ailments, and can make light of one's life by commiting suicide, what is called is made light of one's life by commiting suicide, and is exactly defatting beauty effect, because Pedicellus et Pericarpium Trapae is not containing the fat making people get fat.Say in Compendium of Material Medica: Pedicellus et Pericarpium Trapae energy tonifying the spleen and stomach, strong stock knee joint, strong power QI invigorating, the useful gastrointestinal of Amylum Trapae medicated porridge, can separate interior-heat, and old people often eats useful.According to pharmacological evaluation report in modern age: Pedicellus et Pericarpium Trapae has certain antitumaous effect.Available anti-treatment of esophagus cancer, gastric cancer, uterus carcinoma etc.

Radix Actinidiae Chinensis: base is former: be the root of Fructus actinidiae chinensis section plant Fructus actinidiae chinensis.The property of medicine: sour, puckery, cool.Function cures mainly: heat-clearing and toxic substances removing, expelling wind and removing dampness, and diuresis is stopped blooding.For rheumatic ostalgia, and the disease such as jaundice.

Herba Wahlenbergiae: base is former: be root or the herb of Campanulaceae Herba Wahlenbergiae.The property of medicine: sweet in the mouth; Micro-hardship; Property is put down.Return spleen, lung meridian.Function cures mainly: replenishing QI to invigorate the spleen, eliminating phlegm and stopping cough, hemostasis.Main deficient impairment caused by overstrain, spontaneous perspiration, night sweat, infantile malnutrition, women leucorrhea, flu, cough, epistaxis, malaria, scrofula.

Rhizoma Cimicifugae: base is former: this product is the dry rhizome of ranunculaceae plant C.heracleifolia, Cimicifuga Dahurica or Rhizoma Cimicifugae.This product is irregular microscler bulk, multi-branched, in nodositas, and long 10 ~ 20cm, diameter 2 ~ 4cm.Surface pitchy or sepia, coarse injustice, has hard thin fibrous root to remain, and have the stem foot trace in several circular cavity above, hole inwall shows netted rill; Uneven below, tool mark of fibrous root.Body is light, and matter is hard, not frangibility, and section is uneven, has crack, fibroid, yellow green or yellowish white.Feeble QI, mildly bitter flavor and puckery.The property of medicine: pungent, micro-sweet, is slightly cold.Return lung, spleen, stomach, large intestine channel.Function cures mainly: deliver rash, heat-clearing and toxic substances removing, elevate a turnable ladder yang-energy.For headache due to pathogenic wind-heat, toothache, aphtha, laryngopharynx swelling and pain, measles without adequate eruption, YANG toxin syndrome sends out speckle, proctoptosis, uterine prolapse.

Herba Linderniae Crustaceae: base is former: be the herb of goatweed Herba Linderniae Crustaceae.The property of medicine: mildly bitter flavor; Light; Cool in nature.Function cures mainly: clearing away heat-damp and promoting diuresis, promoting blood circulation and stopping pain.Main anemopyretic cold, damp-heat dysentery, oedema due to nephritis, leucorrhea, menoxenia, carbuncle furuncle and phyma poison, venom, traumatic injury.

Herba tetragoniae: base is former: be the herb of Aizoaceae plant Herba tetragoniae.The property of medicine: sweet, micro-pungent, property is put down.Return lung, liver, large intestine channel.Function cures mainly: wind and heat dispersing, removing toxic substances and promoting subsidence of swelling.The hot conjunctival congestion of main air, treats skin ulcer and swells and ache, enteritis, septicemia, tumor.

Thallus Laminariae (Thallus Eckloniae): base is former: be the thallus of Laminariaceae (Laminariophyceae) plant Thallus Laminariae (Thallus Eckloniae) and the black Thallus Laminariae (Thallus Eckloniae) of Alariaceae plant, Thallus Laminariae.The property of medicine: salty; Cold; Nontoxic.Return liver, stomach, kidney, spleen channel.Function cures mainly: eliminating phlegm and softening indurated mass; Diuretic detumescent.Main scrofula, goiter, dysphagic, (Epileptic is ruined) hernia beriberi edema.

Rhizoma Pinelliae Preparatum: base is former: be the Preparation process product of the Rhizoma Pinelliae.The property of medicine: pungent, temperature.Return spleen, stomach, lung meridian.Function cures mainly: drying dampness to eliminate phlegm.For abundant expectoration cough with asthma, phlegm retention vertigo and palpitation, dizziness due to wind-phlegm, syncope due to accumulation of phlegm is had a headache.

Fructus Aurantii: base is former: be the mellow fruit nearly such as rutaceae Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus), Citrus aurantium Linn., fragrant circle or Citrus aurantium L. var. amara Engl..The property of medicine: bitter, sour, is slightly cold.Return lung, spleen, liver, stomach, large intestine channel.Function cures mainly: dispelling the stagnated QI, row expectorant, removing food stagnancy.Control chest and diaphragm expectorant stagnant, the feeling of stuffiness in chest, coerce swollen, food stagnation, eructation, vomiting, heavy after dysentery, proctoptosis, uterine prolapse.

Rhizoma Chuanxiong: base is former: be the dry rhizome of samphire Rhizoma Chuanxiong.The property of medicine: pungent, temperature.Return liver, gallbladder, pericardium channel.Function cures mainly: blood-activating and qi-promoting, wind-expelling pain-stopping.For menoxenia, amenorrhea dysmenorrhea ， mass in the abdomen is suffered from abdominal pain, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia.

Concha Arcae: have another name called Carnis Arca inflata shell, watt room, blood clam skin, row of tiles on a roof clam skin, for Carnis Arca inflata section Carnis Arca inflata belongs to the shell that animal Scapharca subcrenata, Scapharca broughtonii and Tegillarca granosa belong to animal Tegillarca granosa.The property of medicine: matter is hard, sweet in the mouth, salty, property is put down.Composition: main component is calcium carbonate, also containing a small amount of calcium phosphate and magnesium, ferrum, silicate.Find according to modern pharmacological research, this medical instrument has effect of expectorant blood stasis dispelling, hard masses softening and resolving, relieving gastric hyperacidity to alleviate stomachache, for pertinacious phlegm chronic cough, and stomachache acid regurgitation, traumatic hemorrhage, gastric and duodenal ulcers.

test example 1the clinical practice of the hard masses softening and resolving agent (embodiment 5) of gained treatment gastric cancer of the present invention: in March ,-2010 in June, 2007, the patients with gastric cancer all made a definite diagnosis through pathology 5 hospital's screening 280 examples carries out clinical observation.Be divided into two groups at random, experimental group and matched group (often organizing 140 people).Experimental group male 85 example, women 55 example, 56 years old ~ 65 years old age, the course of disease 1 month ~ 11 months; Matched group male 84 example, women 56 example, 57 ~ 64 years old age, the course of disease 1 month ~ 11 months.Two groups of patients compare in the physical data such as age, the state of an illness, and there was no significant difference, has comparability.Experimental group uses gained of the present invention to treat the hard masses softening and resolving agent of gastric cancer, and using method: three times on the one, each 12g, boiled water is taken after mixing it with water, and within 4 weeks, is a course for the treatment of.Matched group adopts operative treatment, postoperative chemotherapy.After two groups of patients all treat three courses for the treatment of, carry out Comparison of therapeutic.

Curative effect situation criterion: complete incidence graph (CR): cases of complete remission, maintains more than 4 weeks; Partial rcsponse (PR): tumor regression more than 50%, and maintain more than 4 weeks; Stable disease (SD): tumor regression < 50%, or tumor increases < 25%, and maintain more than 4 weeks; Disease progression (PD): tumor increases > 25% or occurs new pathological changes.Always effectively comprise complete incidence graph and partial rcsponse.Result is as shown in table 1.

Table 1: the hard masses softening and resolving agent compliance test result [example (%)] of gained treatment gastric cancer of the present invention

Therapeutic effect: in 140 routine patients of experimental group, complete incidence graph 55 example, accounts for 39.28%; Partial rcsponse 81 example, accounts for 57.86%; Stable disease 2 example, accounts for 1.43%; Disease progression 2 example, accounts for 1.43%; Total effective rate reaches 97.14%.In 140 routine patients of matched group, complete incidence graph 17 example, accounts for 12.14%; Partial rcsponse example 72 example, accounts for 51.43%; Stable disease 37 example, accounts for 26.43%; Disease progression 14 example, accounts for 10%; Total effective rate is 63.57%.Experimental group total effective rate is obviously better than matched group, and two groups of comparing differences have significance.

The Chinese medicine preparation that the present invention makes for primary raw material with pure natural Chinese herbal medicine such as Cortex Cinnamomi, Flos Caryophylli, Rhizoma Corydalis and Radix Patriniae heterophyllaes.In side, Cortex Cinnamomi is mended fiery supporing yang, let the fire back to its origin, dispersing cold for relieving pain, warming the meridian and promoting blood circulation.Flos Caryophylli warming middle-JIAO to send down the adverse QI, reinforcing the kidney and supporting YANG.Rhizoma Corydalis is invigorated blood circulation, dissipating blood stasis, regulates the flow of vital energy, pain relieving.Radix Patriniae heterophyllae dampness leukorrhagia stopping, astringing to arrest bleeding, heat-clearing and toxic substances removing.Radix et Caulis Opuntiae Dillenii promoting flow of QI and blood, heat-clearing and toxic substances removing, cooling blood for hemostasis, clearing away lung-heat to relieve cough.FLOS MUME suppressing the hyperactive liver and easing the stomach.Radix Codonopsis invigorating the spleen and replenishing QI, spleen invigorating lung benefiting.Folium et Ramulus Cephalotaxi is anticancer.Pedicellus et Pericarpium Trapae invigorating spleen and reinforcing stomach, relieving restlessness order is thirsty, removing toxic substances.Radix Actinidiae Chinensis heat-clearing and toxic substances removing, expelling wind and removing dampness, diuresis is stopped blooding.Herba Wahlenbergiae replenishing QI to invigorate the spleen, eliminating phlegm and stopping cough, hemostasis.Rash delivered by Rhizoma Cimicifugae, heat-clearing and toxic substances removing, elevate a turnable ladder yang-energy.Herba Linderniae Crustaceae clearing away heat-damp and promoting diuresis, promoting blood circulation and stopping pain.Herba tetragoniae wind and heat dispersing, removing toxic substances and promoting subsidence of swelling.Thallus Laminariae (Thallus Eckloniae) eliminating phlegm and softening indurated mass, diuretic detumescent.Rhizoma Pinelliae Preparatum drying dampness to eliminate phlegm.Fructus Aurantii dispelling the stagnated QI, row expectorant, removing food stagnancy.Rhizoma Chuanxiong blood-activating and qi-promoting, wind-expelling pain-stopping.Concha Arcae has effect of expectorant blood stasis dispelling, hard masses softening and resolving, relieving gastric hyperacidity to alleviate stomachache.All medicines share, there is the effects such as heat-clearing and toxic substances removing, suppressing the hyperactive liver and easing the stomach, invigorating the spleen and replenishing QI, anticancer analgetic, replenishing QI to invigorate the spleen, clearing away heat-damp and promoting diuresis, blood circulation promoting and blood stasis dispelling, hard masses softening and resolving, counteracting toxic substances and righting are laid equal stress on, conditioning viscera meridians physiological function, whole body can be improved to tumor defence and resistivity, strengthen the antitumor immune function of patient self, improve life quality and survival rate.

Finally it should be noted that, embodiment is the detailed description of the invention of optimum of the present invention, be not limited to the present invention, although with reference to previous embodiment to invention has been detailed description, for a person skilled in the art, it still can be modified to the technical scheme described in foregoing embodiments, or carries out equivalent replacement to wherein portion of techniques feature.Within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims (10)

1. treat a hard masses softening and resolving agent for gastric cancer, it is characterized in that, take off the primary raw material medicine stating weight proportion and be prepared from: Cortex Cinnamomi 13-20, Flos Caryophylli 11-15, Rhizoma Corydalis 12-18, Radix Patriniae heterophyllae 9-13, Radix et Caulis Opuntiae Dillenii 7-12, FLOS MUME 9-14, Radix Codonopsis 12-19, Folium et Ramulus Cephalotaxi 6-13, Pedicellus et Pericarpium Trapae 9-11, Radix Actinidiae Chinensis 10-13, Herba Wahlenbergiae 12-17, Rhizoma Cimicifugae 7-12, Herba Linderniae Crustaceae 8-14, Herba tetragoniae 7-11, Thallus Laminariae (Thallus Eckloniae) 9-15, Rhizoma Pinelliae Preparatum 6-14, Fructus Aurantii 9-12, Rhizoma Chuanxiong 10-13, Concha Arcae 6-9.

2. the hard masses softening and resolving agent for the treatment of gastric cancer as claimed in claim 1, is characterized in that, take off the primary raw material medicine stating weight proportion and be prepared from: Cortex Cinnamomi 15-18, Flos Caryophylli 12-14, Rhizoma Corydalis 15-17, Radix Patriniae heterophyllae 10-12, Radix et Caulis Opuntiae Dillenii 9-11, FLOS MUME 10-12, Radix Codonopsis 14-17, Folium et Ramulus Cephalotaxi 8-11, Pedicellus et Pericarpium Trapae 9.5-10.5, Radix Actinidiae Chinensis 11-12.5, Herba Wahlenbergiae 13-15, Rhizoma Cimicifugae 8-10, Herba Linderniae Crustaceae 10-13, Herba tetragoniae 8-10, Thallus Laminariae (Thallus Eckloniae) 11-13, Rhizoma Pinelliae Preparatum 8-12, Fructus Aurantii 9.5-11, Rhizoma Chuanxiong 11-12, Concha Arcae 7-8.

3. the hard masses softening and resolving agent for the treatment of gastric cancer as claimed in claim 1, is characterized in that, take off the primary raw material medicine stating weight proportion and be prepared from: Cortex Cinnamomi 16, Flos Caryophylli 13, Rhizoma Corydalis 16, Radix Patriniae heterophyllae 11, Radix et Caulis Opuntiae Dillenii 10, FLOS MUME 11, Radix Codonopsis 16, Folium et Ramulus Cephalotaxi 10, Pedicellus et Pericarpium Trapae 10, Radix Actinidiae Chinensis 11.5, Herba Wahlenbergiae 14, Rhizoma Cimicifugae 9, Herba Linderniae Crustaceae 12, Herba tetragoniae 9, Thallus Laminariae (Thallus Eckloniae) 12, Rhizoma Pinelliae Preparatum 9, Fructus Aurantii 10, Rhizoma Chuanxiong 11.5, Concha Arcae 7.5.

4. the hard masses softening and resolving agent of the treatment gastric cancer as described in as arbitrary in claims 1 to 3, it is characterized in that, pharmaceutically acceptable granule is made in the hard masses softening and resolving agent of this treatment gastric cancer, and the preparation method of described granule is:

(1) boiled by Pedicellus et Pericarpium Trapae and shell, be cut into grain of rice size, dry at the temperature of 45-55 DEG C, dry 25-42 hour, is ground into fine powder, crosses No. six sieves;

(2) by all the other except Pedicellus et Pericarpium Trapae 18 taste crude drug pulverization respectively, No. six sieves are crossed;

(3) by step (1) and step (2) gained mix homogeneously, add the alcoholic solution that mass fraction is 60%-70%, stir, to " hands is pinched agglomerating, namely faling apart of pressure ", 16-20 mesh sieve granulates (preferably granulating on 18 mesh sieves), make uniform granule, dry at the temperature of 50 DEG C-60 DEG C (preferably dry at the temperature of 55 DEG C), dry 3-5 hour (preferably dry 4 hours), granulate, sub-sieve, to obtain final product.

5. the preparation method of the hard masses softening and resolving agent for the treatment of gastric cancer as claimed in claim 4, is characterized in that, dry at the temperature of 50 DEG C in step (1).

6. the preparation method of the hard masses softening and resolving agent for the treatment of gastric cancer as claimed in claim 4, is characterized in that, drying 36 hours in step (1).

7. the preparation method of the hard masses softening and resolving agent for the treatment of gastric cancer as claimed in claim 4, is characterized in that, add the alcoholic solution that mass fraction is 65% in step (3).

8. the hard masses softening and resolving agent of the treatment gastric cancer as described in as arbitrary in claims 1 to 3, it is characterized in that, pharmaceutically acceptable tablet is made in the hard masses softening and resolving agent of this treatment gastric cancer, and the preparation method of described tablet is:

(1) boiled by Pedicellus et Pericarpium Trapae and shell, be cut into grain of rice size, dry at the temperature of 45-55 DEG C (preferably dry at the temperature of 50 DEG C), dry 25-42 hour (preferably dry 36 hours), are ground into fine powder, cross No. five sieves;

(2) by all the other except Pedicellus et Pericarpium Trapae 18 taste crude drug pulverization respectively, No. five sieves are crossed;

(3) by step (1) and step (2) gained mix homogeneously, add the alcoholic solution (preferably adding the alcoholic solution that mass fraction is 65%) that mass fraction is 60%-70%, stir, to " hands is pinched agglomerating; namely faling apart of pressure ", 16-20 mesh sieve is granulated (preferably granulating on 18 mesh sieves), makes uniform granule, dry at the temperature of 50 DEG C-60 DEG C (preferably dry at the temperature of 55 DEG C), dry 3-5 hour (preferably dry 4 hours), tabletting, the heavy 0.5g of every sheet, to obtain final product.

9. the hard masses softening and resolving agent of the treatment gastric cancer as described in as arbitrary in claims 1 to 3, it is characterized in that, pharmaceutically acceptable capsule is made in the hard masses softening and resolving agent of this treatment gastric cancer, and the preparation method of described capsule is:

(1) boiled by Pedicellus et Pericarpium Trapae and shell, be cut into grain of rice size, dry at the temperature of 45-55 DEG C (preferably dry at the temperature of 50 DEG C), dry 25-42 hour (preferably dry 36 hours), are ground into fine powder, cross No. five sieves;

(2) by all the other except Pedicellus et Pericarpium Trapae 18 taste crude drug pulverization respectively, No. five sieves are crossed;

(3) by step (1) and step (2) gained mix homogeneously, add the alcoholic solution (preferably adding the alcoholic solution that mass fraction is 65%) that mass fraction is 60%-70%, stir, to " hands is pinched agglomerating, namely faling apart of pressure ", 16-20 mesh sieve granulates (preferably granulating on 18 mesh sieves), make uniform granule, dry at the temperature of 50 DEG C-60 DEG C (preferably dry at the temperature of 55 DEG C), dry 3-5 hour (preferably dry 4 hours), load zero capsule, every capsules is equipped with medicated powder 0.32g, by the capsule polishing in buffing machine installed, pressing plate, obtain.

10. the hard masses softening and resolving agent of the treatment gastric cancer as described in as arbitrary in claims 1 to 3, it is characterized in that, pharmaceutically acceptable pill is made in the hard masses softening and resolving agent of this treatment gastric cancer, and the preparation method of described pill is:

(1) boiled by Pedicellus et Pericarpium Trapae and shell, be cut into grain of rice size, dry at the temperature of 45-55 DEG C (preferably dry at the temperature of 50 DEG C), dry 25-42 hour (preferably dry 36 hours), are ground into fine powder, cross No. five sieves;

(2) by all the other except Pedicellus et Pericarpium Trapae 18 taste crude drug pulverization respectively, No. five sieves are crossed;

(3) by step (1) and step (2) gained mix homogeneously, take mass fraction as the alcoholic solution pill of 75%, make the pill of the heavy 0.5g of every ball, gained pill is dry at the temperature of 55 DEG C, make water content control 9%, be taken out to and cool completely, to obtain final product.