CN101518593A

CN101518593A - Traditional Chinese medicine composition for curing hyperplasia of mammary glands and resisting tumors and preparation method thereof

Info

Publication number: CN101518593A
Application number: CN200910118808A
Authority: CN
Inventors: 张之霞; 韩洪冰
Original assignee: Individual
Current assignee: Individual
Priority date: 2009-03-02
Filing date: 2009-03-02
Publication date: 2009-09-02
Anticipated expiration: 2029-03-02
Also published as: CN101518593B

Abstract

The invention discloses a traditional Chinese medicine composition for curing hyperplasia of mammary glands and resisting tumors and a preparation method thereof. The medicine for oral administration contains the components by weight: 10-30 portions of Chinese thorowax, 10-30 portions of radix codonopsitis, 10-30 portions of milk veteh, 10-30 portions of angelica, 10-30 portions of Flos Albiziae, 10-30 portions of selfheal, 10-30 portions of perilla leaf, 10-30 portions of Paeonia lactiflora pallas, 10-30 portions of trumpet creeper, 10-30 portions of Herba Patriniae, 10-20 portions of gekko, 10-30 portions of safflower, 10-30 portions of medlar, 10-30 portions of trogopterus dung, 10-30 portions of myrrh, 10-30 portions of pistachia galls and 10-30 portions of gamboges; and the external used medicine contains the components by weight: 1-10 portions of rhizoma arisaematis, 10-30 portions of Salvia miltiorrhiza, 10-30 portions of rhizoma drynariae, 10-30 portions of trumpet creeper, 10-30 portions of spatholobus stem, 10-30 portions of red paeonia, 10-30 portions of safflower, 10-30 portions of trogopterus dung, 10-20 portions of gekko, 10-30 portions of dandelion and 10-30 portions of borneol.

Description

A kind of treatment cyclomastopathy and antineoplastic Chinese medicine composition and preparation method thereof

Technical field

The present invention relates to contain the medicinal preparation that derives from plant, animal or mineral component, particularly a kind of treatment cyclomastopathy and antineoplastic Chinese medicine composition and preparation method thereof

Background technology

In recent years, along with the variation of living environment, the cyclomastopathy sickness rate rises very fast, and this disease has become the main killer of Urban Women.In case the trouble cyclomastopathy, except pain, lump, the patient must have agitation emotionally, irritability, and fears etc. have function reduction on the physiology, indifferent as libido, menoxenia, physically-draining, frequent micturition etc., many with gynaecopathia on pathology, endometriosis etc.This is failed the comprehensive treating both the principal and secondary aspects of a disease of whole body, controlling for a long time has no resolution just the danger that transfers breast carcinoma to.

Cyclomastopathy belongs to the category of the traditional Chinese medical science " nodules of the breast ", how to hinder newborn network by worry impairing spleen, angry impairing the liver, Chong and Ren channel disorder, the stasis of blood and forms.Woman's nipple belongs to liver, and breast belongs to stomach, and The spleen and the stomach are interior-exteriorly related, and liver happiness bar reaches, anxiety and rage, and the liver failing to maintain the normal flow of QI then, spleen is impaired, causes the stagnation of QI expectorant blood coagulation stasis of blood, breast caking pain occurs.CHONG meridian being the blood pool again, REN meridian connecting with the uterus and pregnancy, two through following abdomen whereabouts pass through the liver diaphragm on the kidney meridian and join in the heart with breast, dash wantonly two arteries and veins and be under the jurisdiction of Liver and kidney, Chong and Ren channel disorder, mental disorder pent-up, deficiency of the liver and kindey, lump in breast pain appears in knot in the yang deficiency phlegm-damp, and with change in menstrual cycle.

The factor that about according to statistics 85% patient has stagnation of liver-QI not relax is so depression of liver-QI is the main pathogenesis of primary disease, again because of primary disease changes with menstrual cycle, with kidney and directly related towards appointing.Thereby the pathomechanism of primary disease belongs to deficiency in origin and excess in superficiality, and promptly it is marked on liver, the fundamental cause of water disease being in the kidney.The rule of treatment should be with dispersing the stagnated live-QI to relieve the stagnation of QI, disperse blood stasis and dredge collateral, and Chong and Ren Meridians regulating, hard masses softening and resolving are main.External treatment with Chinese medicine is viscera, meridians, QI and blood to be carried out integrally-regulatedly under the differentiation of tcm theoretical direction, makes medicine and physical agent directly act on diseased region quickly, by generation effects such as dermal osmosis, mucosa absorption, acupoint stimulations.Medicine can promote regional flow among depressed liver-energy dispersing and QI regulating, the activating collaterals and eliminating stagnation, improves cellular metabolism, the endocrine regulation function.

The traditional Chinese medical science thinks that breast belongs to stomach on the meridians route distributes, and nipple belongs to liver.The lid liver is general's official, and property happiness bar reaches, as is subjected to direct stimulation, and the stagnation of QI is lost and dredged, and perverse and unreasonable manner is violated stomach, the resistance of stagnation of liver-QI stomach, and the pathogens agglomerating meridians form " mastopathia ".Because conception vessel and Liver Channel are closely related, two through going together and lower abdomen, and some acupuncture points on the human body of conception vessel such as Qugu, the middle utmost point, cv etc. are all met with Liver Channel.When through water in the future in, abundance of blood in CHONG meridian, resembling of Liver Channel stasis is more outstanding, on then see uncomfortable in chest, mammary swelling pain, nextly see lower abdominal distention pain.After water came, the sea of blood was empty temporarily, and stagnation of liver-QI is alleviated, so mammary swelling abdominal distention is also flat.So periodically outbreak repeatedly, then the breast caking does not loose, and pain exacerbates, and the growth and decline with susceptible to anger.

Cyclomastopathy also is a kind of incretion disease relevant with ovarian dysfunction.Often by melancholy impairing the liver, depression and stagnation of QI; Worry impairing spleen accumulates in the phlegm-damp, so that dry phlegm-syndrome ties mutually, and the stasis of blood in bulk that stagnates is tied in newborn network and formed.Or by deficiency of the liver and kindey, Chong and Ren channel disorder, breast is become homeless foster, and the dry phlegm-syndrome blood stasis lumps and forms in newborn network.Be characterized in: one-sided or bilateral mastalgia also lump occurs, and mastalgia and lump and menstrual cycle and feelings will change closely related.Lump in breast differs in size, and form differs, obscure boundary, and the matter piece is not hard, and mobility is good, touches a tender spot.Good sending out in young women.The primary disease course of disease reaches the several years, and therefore, early stage active treatment primary disease has significance.Primary disease has certain canceration danger, especially to the patient with the breast carcinoma family history, more should pay much attention to.

Cyclomastopathy has gently, in, the branch of weight.The lighter mostly is stagnation of QI due to depression of the liver, is main with depressed liver-energy dispersing and QI regulating, and assistant blood stasis dispelling method has good effect.Middle person mostly is the stagnation of liver-QI expectorant stasis of blood, and the Chong and Ren channel disorder of holding concurrently is controlled suitable hard masses softening and resolving, and the promoting flow of QI and blood pain relieving is main, is aided with the product of soothing liver-QI for relieving depression.Weight person be the expectorant stasis of blood with the passing of time, dash to appoint disorderlyly, control suitable removing blood stasis eliminating stagnation, the blood stasis dispelling softening the hard mass.

At present, for a long time to adopt endocrine therapy, use low dose of potassium iodide preparation and tranquilizer 50～sixties both at home and abroad, energy respite breast mastalgia, but the detumescence effect is poor.The female powder of oral afterwards ethylene, the intramuscular injection Progesterone, and, adjust the endocrine disturbance with androgen and androgen derivant danazol, relief of symptoms, but should not grasp the course of treatment, and cause side effect easily.It is attractive in appearance that operative treatment influences women's stature curve very much, brings huge misery for women's body and mind.Chinese traditional treatment often takes effect slowly, weak curative effect, and specific aim is not strong, and the cycle is very long.Up to now, domestic and international method and the measure that does not occur as yet the well-content therapeutic effect of primary disease.

Summary of the invention

Technical problem to be solved by this invention is, a kind of treatment cyclomastopathy and antineoplastic Chinese medicine composition and preparation method thereof are provided, cyclomastopathy and mammary neoplasms at various degree, the curative effect of medication of treatment cyclomastopathy is all undesirable on the market, slower shortcoming takes effect, on the basis of traditional medicine,, adopt modern processing method to develop meticulously in conjunction with clinical experience for many years.The present invention is a kind of instant effect, without any side effects, the lasting Chinese medicine composition of a specified duration of effect to each effective ingredient science compatibility of component medicine, and the combination of inner and outside, and treating both the principal and secondary aspects of a disease can be taught the misery that solves the patient on the big degree.

For solving the problems of the technologies described above, it is simple to the invention provides a kind of prescription, processing technology is simple, be suitable for the Chinese medicine composition that the various different causes of disease cause cyclomastopathy, form by endo-medicine and external used medicine, the ratio of weight and number of various components is in the described endo-medicine: 10～30 parts of Radix Bupleuri, 10～30 parts of Radix Codonopsis, 10～30 parts of the Radixs Astragali, 10～30 parts of Radix Angelicae Sinensis, 10～30 parts of Flos Albiziaes, 10～30 parts of Spica Prunellaes, 10～30 parts of Folium Perillaes, 10～30 parts of the Radix Paeoniae Albas, 10～30 parts of Flos Campsiss, 10～30 parts of Herba Patriniae, 10～20 parts of Gekko Swinhonis Gekko Swinhonis, 10～30 parts on Flos Carthami, 10～30 parts of Fructus Lycii, 10～30 parts of Oletum Trogopteroris, 10～30 parts of Myrrhas, 10～30 parts of Olibanums, 10～30 parts of Resina garciniaes;

The ratio of weight and number of various components is in the described external used medicine: 1～10 part of Rhizoma Arisaematis, 10～30 parts of Radix Salviae Miltiorrhizaes, 10～30 parts of Rhizoma Drynariae, 10～30 parts of Flos Campsiss, 10～30 parts of Caulis Spatholobis, 10～30 parts of Radix Paeoniae Rubra, 10～30 parts on Flos Carthami, 10～30 parts of Oletum Trogopteroris, 10～20 parts of Gekko Swinhonis Gekko Swinhonis, 10～30 parts of Herba Taraxacis, 10～30 parts of Borneolum Syntheticums.

Described treatment cyclomastopathy and antineoplastic Chinese medicine composition, the ratio of weight and number of various components can be preferably in the endo-medicine: 10～15 parts of Radix Bupleuri, 10～15 parts of Radix Codonopsis, 10～15 parts of the Radixs Astragali, 10～15 parts of Radix Angelicae Sinensis, 10～15 parts of Flos Albiziaes, 10～15 parts of Spica Prunellaes, 10～15 parts of Folium Perillaes, 10～15 parts of the Radix Paeoniae Albas, 10～15 parts of Flos Campsiss, 10～15 parts of Herba Patriniae, 10～15 parts of Gekko Swinhonis Gekko Swinhonis, 15～20 parts on Flos Carthami, 15～20 parts of Fructus Lycii, 15～20 parts of Oletum Trogopteroris, 15～20 parts of Myrrhas, 15～20 parts of Olibanums, 15～20 parts of Resina garciniaes;

The ratio of weight and number of various components can be preferably in the described external used medicine: 3～7 parts of Rhizoma Arisaematiss, 15～20 parts of Radix Salviae Miltiorrhizaes, 15～20 parts of Rhizoma Drynariae, 15～20 parts of Flos Campsiss, 15～20 parts of Caulis Spatholobis, 15～20 parts of Radix Paeoniae Rubra, 15～20 parts on Flos Carthami, 15～20 parts of Oletum Trogopteroris, 10～15 parts of Gekko Swinhonis Gekko Swinhonis, 15～20 parts of Herba Taraxacis, 15～20 parts of Borneolum Syntheticums.

The ratio of weight and number of various components also can be preferably in described treatment cyclomastopathy and the antineoplastic Chinese medicine composition endo-medicine: 15～20 parts of Radix Bupleuri, 15～20 parts of Radix Codonopsis, 15～20 parts of the Radixs Astragali, 15～20 parts of Radix Angelicae Sinensis, 15～20 parts of Flos Albiziaes, 15～20 parts of Spica Prunellaes, 15～20 parts of Folium Perillaes, 15～20 parts of the Radix Paeoniae Albas, 15～20 parts of Flos Campsiss, 15～20 parts of Herba Patriniae, 10～15 parts of Gekko Swinhonis Gekko Swinhonis, 10～15 parts on Flos Carthami, 10～15 parts of Fructus Lycii, 10～15 parts of Oletum Trogopteroris, 10～15 parts of Myrrhas, 10～15 parts of Olibanums, 10～15 parts of Resina garciniaes;

The ratio of weight and number of various components also can be preferably in the described external used medicine: 4～8 parts of Rhizoma Arisaematiss, 20～25 parts of Radix Salviae Miltiorrhizaes, 20～25 parts of Rhizoma Drynariae, 20～25 parts of Flos Campsiss, 20～25 parts of Caulis Spatholobis, 20～25 parts of Radix Paeoniae Rubra, 20～25 parts on Flos Carthami, 20～25 parts of Oletum Trogopteroris, 15～20 parts of Gekko Swinhonis Gekko Swinhonis, 20～25 parts of Herba Taraxacis, 20～25 parts of Borneolum Syntheticums.

Described treatment cyclomastopathy and antineoplastic Chinese medicine composition, the ratio of weight and number of various components also can be preferably in the endo-medicine: 25～30 parts of Radix Bupleuri, 25～30 parts of Radix Codonopsis, 25～30 parts of the Radixs Astragali, 25～30 parts of Radix Angelicae Sinensis, 25～30 parts of Flos Albiziaes, 25～30 parts of Spica Prunellaes, 25～30 parts of Folium Perillaes, 25～30 parts of the Radix Paeoniae Albas, 25～30 parts of Flos Campsiss, 25～30 parts of Herba Patriniae, 15～20 parts of Gekko Swinhonis Gekko Swinhonis, 25～30 parts on Flos Carthami, 25～30 parts of Fructus Lycii, 25～30 parts of Oletum Trogopteroris, 25～30 parts of Myrrhas, 25～30 parts of Olibanums, 25～30 parts of Resina garciniaes;

The ratio of weight and number of various components also can be preferably in the described external used medicine: 5～9 parts of Rhizoma Arisaematiss, 15～30 parts of Radix Salviae Miltiorrhizaes, 15～30 parts of Rhizoma Drynariae, 15～30 parts of Flos Campsiss, 15～30 parts of Caulis Spatholobis, 15～30 parts of Radix Paeoniae Rubra, 15～30 parts on Flos Carthami, 15～30 parts of Oletum Trogopteroris, 15～20 parts of Gekko Swinhonis Gekko Swinhonis, 15～30 parts of Herba Taraxacis, 15～30 parts of Borneolum Syntheticums.

Described treatment cyclomastopathy and antineoplastic Chinese medicine composition, endo-medicine can be fried in shallow oil decoction in use and take, and 1 dose of every day, decocting is obeyed at twice, and per 7 days is a course of treatment.

Described treatment cyclomastopathy and antineoplastic Chinese medicine composition, the dosage form of endo-medicine can be honey refining pill, hydration pill, capsule, oral liquid, granule, colloid or syrup.

Described treatment cyclomastopathy and antineoplastic Chinese medicine composition, the endo-medicine dosage form is tablet or powder, when taking, can one day three times, per 7 days is a course of treatment.

For solving the problems of the technologies described above, the present invention also provides a kind of preparation method for the treatment of cyclomastopathy and antineoplastic Chinese medicine composition, and endo-medicine is that capsular preparation comprises:

According to described portion rate with Gekko Swinhonis Gekko Swinhonis with 95% soak with ethanol three times, each soak time was respectively 2 hours, 1 hour, 1 hour; Each 80～85 ℃ of heat in back of soaking are extracted; The ratio of weight and number of used ethanol and Gekko Swinhonis Gekko Swinhonis is respectively: for the first time 10 times of amounts, the second time 6 times of amounts, 6 times of amounts for the third time; Merge three times ethanol extract, be concentrated into relative density and be 1.06 concentrated solution, stand for standby use; Residue after the aforementioned extraction and other described components merge, and 80～100 ℃ of decoctings boil three times, and decocting time was respectively 2 hours, 1.5 hours, 1 hour; The ratio of weight and number of institute's water and residue and other component gross weights is respectively: for the first time 10 times of amounts, the second time 8 times of amounts, 6 times of amounts for the third time; Merge three times decoction liquor, be concentrated into relative density and be 1.08 concentrated solution; With decocting and concentrating liquid and the merging of ethanol concentrated solution, filtration, spray drying, granulation, encapsulated again.

For solving the problems of the technologies described above, the present invention also provides the preparation method of treatment cyclomastopathy and antineoplastic Chinese medicine composition, and the preparation of external used medicine may further comprise the steps:

With Gekko Swinhonis Gekko Swinhonis, Rhizoma Arisaematis is put into 85% above ethanol extraction 1 time.Promptly use soak with ethanol, 80～90 ℃ of heat are extracted, and the time is more than 2 hours.Reclaim ethanol then, the medicinal liquid stand for standby use after the filtering and concentrating; Residue and other drug merge, and remove Borneolum Syntheticum and add the water logging bubble 30 minutes to 1 hour, and heating was boiled 30～40 minutes, filtered filtrate for later use; Filtering residue adds water and heats for the second time, boils 20～30 minutes, filters; Three filtrates are lumped together, and heating is concentrated into pasty state, puts into the mixed fine-powdered that grinds to form of baking oven 80 ℃ of oven dry postcooling and Borneolum Syntheticum; Mixed then vaseline furnishing pasty state spreads out on oilpaper, sticks the breast tumor place and gets final product.。

For solving the problems of the technologies described above, the present invention provides a kind of preparation method for the treatment of cyclomastopathy and antineoplastic Chinese medicine composition again, and the preparation of external used medicine may further comprise the steps:

Described component is mixed by proportioning except that Borneolum Syntheticum, drop into pulverizer and be ground into fine powder, put into the acid and alkali-resistance infusion kettle after fine powder sieves, at normal temperatures, flooded 15～30 days with ethanol, liquid and medicinal residues that dipping is good carry out squeeze and filter, get filtrate after the separation, pulverize Borneolum Syntheticum and add filtrate, stir, mixed then vaseline furnishing pasty state spreads out on oilpaper, sticks the breast tumor place and gets final product.

Patient's wash clean patient part pasted potion breast of the present invention and was affixed on the affected part every night, took off after 24 hours to get final product.The agent of external of the present invention card can 7 days is to use a course of treatment, and is difficult for pollution clothes, easy to use.

The present invention treats the Chinese drug-treated group cyclomastopathy and the antineoplastic Chinese medicine composition can be given full play to the medicine greatest treatment efficacy, it is good to have safety, the advantage that feasibility is good, compared with prior art religion, present technique has convenient drug administration, through patient part, and targeting is strong, advantages such as medicament is easy to make, and is with low cost.The present invention adopts the Chinese crude drug of the different property of medicine, has carried out the science compatibility, can reach ideal therapeutic effect, and safety, without any side effects, easy to use, cure the back and be difficult for recurrence, and cheap, easy to use, can create good social and be worth and economic interests.

The specific embodiment

Motherland's medical science is referred to as nodules of the breast to cyclomastopathy, has both comprised mammary gland body of gland hyperplasia of prostate, comprise that again the mammary gland fibroadenoma sample becomes, and says as " Yangke Xinde Ji, Experience Gained in Treating External Diseases ": " nodule in the breast shape such as ball ovum, not pain, do not have a fever; its color is constant, and it is examined with the susceptible to anger growth and decline, this nodules of the breast." nodules of the breast is fallen ill many and liver, kidney, stomach reach towards appointing in close relations.Wherein close to see from the determining the pathogenesis of ZANG-FU disease based on the differentiation of symptoms and signs angle with liver, kidney relation, because of liver be that the woman is congenital, main store blood, department's sea of blood is in harmonious proportion and dashes times; Nipple belongs to liver, and the channels of liver follows breast and goes, and the liver body is cloudy and with sun, the main liter sent out a catharsis, ponders over or angry impairing the liver as sorrow, makes functional activity of QI being not smooth, and the newborn network stasis of blood is stagnant, with the passing of time lump formation due to accumulation of pathogens.The kidney being the origin of congenital constitution, root of YIN and YANG, and the vital essence direct bearing is changed and is given birth to menses, executes and lets out in uterus, so have beginning, the vessels of the uterus of menstruation to lie in saying of kidney.Chong channel arises from uterus, on loose in breast, interior and newborn network, thus the Liver and kidney two dirty parts of the body cavity below the umbilicus, housing the bladder, kidneys and bowels that are positioned at, transfer altogether dash appoint, uterus, mammary gland.

The Coryza Treated by Syndrome Differentiation of adolescence cyclomastopathy wherein, because of it has hebetic pathogenic characteristic, adolescence women's body constitution mostly is the young positive state of young the moon, can not send an expedition against simply in the treatment, too stern, the taboo of criminal's making a deficient case more deficient, consumption is let out yang-energy, the empty impairment of QI-blood, loss is cloudy smart, has a surplus tonifying for deficiency syndrome so should attack it.On tonifying YIN, heat clearing away, circulation of qi promoting, pathogenic fire reducing basis, reach blood stasis dispelling, collateral dredging, pain relieving, eliminating stagnation purpose.The Coryza Treated by Syndrome Differentiation of senile cyclomastopathy, because of elderly woman advanced age, liver, kidney two be dirty lose empty, menses depletion, Chong and Ren channel disorder, menses close, stagnation of meridian-QI, expectorant is turbid to be condensed in newborn network, with the passing of time form the addiction piece, treatment should be based on warming and recuperating the kidney-YANG, and assistant is with the activating collaterals and eliminating stagnation pain relieving, and mediate reason Liver and kidney is for wanting.Belong to stage climacteric Coryza Treated by Syndrome Differentiation, because of the climacteric women asthenia of renal qi, deficiency of liver-blood, heart spleen is become estranged, Chong and Ren channel disorder, menses gradually dry up, and controlling should adjusting and reinforcing liver and kidney, nourishing YIN for attracting YANG, nourishing blood to tranquillize the mind are main.This side is from plan side, it also is clinical experience side, give increase and lose according to the different stadium of cyclomastopathy, different phase, accomplish sudden inspiration live method, know and often reach change, reach depressed liver-energy dispersing and QI regulating, dissipating phlegm and resolving masses, mediation towards the effect of appointing, can put down the Ruzhong caking that disappears, the change silt is loose and is saved, nurse one's health internal recycle, reach the purpose for the treatment of both the principal and secondary aspects of a disease.

The Radix Astragali is based on tonify deficiency, can invigorating QI to consolidate the body surface resistance, and diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.Be used for that insufficiency of vital energy and blood, skin infection cave in, difficulty in discharging of pus or burst for a long time and do not hold back the person.The Radix Astragali has the function of good promoting pus discharge and tissue regeneration strengthening, i.e. the abscess suppuration granulation promoting of disunion for a long time.Modern medicine study shows that the Radix Astragali includes and multiple antibiotic effective ingredient, and the energy enhancing body's immunological function, therefore can also be used to prevent the generation of some infectious disease." book on Chinese herbal medicine meets former " carries: " Radix Astragali can all void of tonifying five ZANG-organs, controls the stringy pulse spontaneous perspiration, rushes down YIN-fire, removes lung-heat, losslessly then sends out, and has antiperspirant then to end." be the good medicine of promoting resistance and defence disease.

Fructus Lycii is a liver and the kidney tonifying Chinese medicine commonly used simply, modern medicine study confirms that it contains nutritional labelings such as betaine, polysaccharide, crude fat, crude protein, carotene, vitamin A, vitamin C, vitamin B1, vitamin B2 and calcium, phosphorus, ferrum, zinc, manganese, linoleic acid, hemopoietic function there is facilitation, can also defying age, effect such as mutation, antitumor, anti-fatty liver and blood sugar lowering.The traditional Chinese medical science usually with it treat hepatic and renal YIN deficiency, soreness of the waist and knees, dizziness, forgetful, dizzy, many tears of blurred vision, quench one's thirst, poliosis, alopecia, it is remarkable that diseases such as seminal emission, YIN nourishing are supported the kidney effect.

Radix Angelicae Sinensis, its sweet in the mouth and weighing, so specially can enrich blood, its gas is light and hot, thus again can promoting the circulation of blood, invigorating middle warmer has, in the row benefit is arranged, the gas medicine in the sincere blood, the also panacea in the blood.About mending of assistant to mend then, thus can support nutrition blood, the QI invigorating spermatogenesis, settling five organs, body by force, beneficial mind, all tangible deficient diseases, nothing is unsuitable.Assistant logical to attack then, so the relieving constipation bitterly of dispelling, relieving rigidity of muscles and joints is controlled contracture, paralysis, card such as dry, puckery.Nutrient QI being deficient and exterior syndrome being not relieved person, assistant is with agent such as bavin, Pueraria lobota, fiber crops, osmanthus, the Biao Weire that can loose greatly, and show not hold back the person, and help with Radix Et Rhizoma Rhei and so on, again can consolidating superficial resistance.Precisely because gas Xin Erdong, so desire its quiet person when keeping away it, the sliding benefaction of property is defecated and is not consolidated the person when keeping away it.All cloudy moderate heat Sheng persons, the active blood of Radix Angelicae Sinensis, also non-institute is suitable, cloudy deficiency of YANG of middle-JIAO person, Radix Angelicae Sinensis can nourish blood, and is indispensable.

Radix Codonopsis is flat, sweet in the mouth, little acid.Return spleen, lung meridian.Invigorating the spleen and replenishing QI, the spleen invigorating lung benefiting.Be used for deficiency of the spleen and lung, the cardiopalmus of breathing hard, anorexia and loose stool, the dyspnea due to deficiency cough, interior-heat is quenched one's thirst." book on Chinese herbal medicine justice " carries: Radix Codonopsis power energy spleen reinforcing nourishing the stomach, and the lung moistening and production of body fluid promoting, gas in the tendon fortune, this is very mutually not far away with Radix Ginseng.Its outstanding valuable person, spleen invigorating fortune and not dry is then grown stomach-Yin and wet, and lung moistening and do not violate is cold and coolly nourished blood and is not grown greasyly partially, inspires clear sun, gas in the vibration, and do not have dry fraud just.Radix Astragali QI invigorating, can rise enriching spleen-QI, again can the lung benefiting consolidating superficial resistance.The Radix Codonopsis QI invigorating can only the spleen invigorating QI invigorating, the power of no consolidating superficial resistance, but Radix Codonopsis can also supplementing QI for promoting the production of body fluid, and the Radix Astragali does not then have the effect of promoting the production of body fluid, and the Radix Astragali is held concurrently can diuretic, and Radix Codonopsis does not have the diuretic effect.This two flavors medicine share can invigorating the spleen and replenishing QI, improves resistance.

The Radix Bupleuri hardship is slightly cold.Return liver, gallbladder meridian.The function reconciling superficies and interior, soothing the liver, yang invigorating is used for depression of liver-QI, the pain over the hypochondriac region, menoxenia etc." Yaoxing Fu " carries: bitter in the mouth, flat, feeble QI is cold, and is nontoxic.Rise also, the yang aspect of yin also.It is with having four: about two be close to pain over the hypochondrium, afternoon fever is toward next life.Main blood in dirty regulating menstruation is passed through on flesh master gas.The medicine of few positive the exterior and the interior four warps of brothers also.

Flos Albiziae property is flat, sweet in the mouth.The function resolving stagnation for tranquilization.Be used for irritability, melancholy insomnia.The function that resolving stagnation for tranquilization, promoting blood circulation and detumescence are arranged; Be used for irritability, melancholy insomnia, swollen, the traumatic pain of lung abscess skin ulcer, leaf contains tannin, quercitrin.Flos Albiziae contains the Herba Albiziae glycoside, tannin, and resolving stagnation for tranquilization, the appetizing of regulating the flow of vital energy, activating collaterals to relieve pain is used for irritability, melancholy insomnia.It is uncomfortable in chest to control pent-up, and insomnia is forgetful, and acute conjunctivitis can settling five organs, and will, improving healthy complexion, have preferably keep fit, calm, the effect of calming the nerves, improve looks, also be to treat neurasthenic good merchantable brand.

Spica Prunellae hardship, suffering, cold.Be used for mass dissipating and swelling eliminating more, control scrofula, goiter, acute mastitis and swell and ache." Bencao Congxin " carries it: control scrofula, scrofula, goiter, disease heavily fortified point, acute mastitis, breast carcinoma.Spica Prunellae is the key medicine of clearing away liver-fire, Disperse hepatic depression, and what it cured mainly is the disease of Liver Channel mostly.This product is equipped with Flos Chrysanthemi, Semen Cassiae, but liver heat removing and eyesight improving control conjunctival congestion and swelling pain, be equipped with Concha Haliotidis, Ramulus Uncariae Cum Uncis, but the pancake liver-yang is controlled headache, dizziness; Be equipped with product such as Radix Scrophulariae, Bulbus Fritillariae Uninbracteatae, Concha Ostreae, but hard masses softening and resolving is controlled scrofula and is gone through tuberculosis.Be used for tumor in recent years clinically again.

The Folium Perillae property and flavor of peppery and warm, have deliver, cold expelling, the effect of regulating the flow of vital energy and seeking.The wind and cold that cures cold, fever with aversion to cold, cough, asthma, distension and fullness of the chest and abdomen etc.Compendium of Material Medica is carried " promoting the circulation of QI to alleviate the stagnation in middle-JIAO, the sharp lung of clearing away phlegm, and blood, warming middle-JIAO, pain relieving, Dingchuan, antiabortive ".

The Radix Paeoniae Alba goes into liver, spleen channel, nourishing blood to suppress the hyperactive liver, and slow middle pain relieving, yin fluid astringing is received antiperspirant.Control the breast abdomen pain over the hypochondriac region, dysentery stomachache, spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, leukorrhagia, married woman's blood closes obstructed, and repercussive blood can lose pus, beneficial woman's blood." Japan hanako materia medica ": control wind, mend labor, all diseases of main woman, and all diseases in antenatal back, Tong Yueshui brings down a fever, relieving restlessness, QI invigorating, day hot disease of row, the pestilence miasma, mania and irritation, married woman's blood fortune, and hemorrhoidal hamorrhage are rushed down blood, hemorrhoid complicated by anal fistula.Carbuncle on the back, the skin ulcer scabies, headache makes eye bright, and conjunctival congestion is exerted meat.The many QI invigorating of redness of the skin or complexion person, white person controls blood.

Gekko Swinhonis goes the dry products of internal organs to go into Chinese medicine, and name " Gekko Swinhonis Gekko Swinhonis " has tonifying the lung kidney, benefiting essence-blood, relieving cough and relieving asthma, spasmolytic to dispel the wind and disperses the repercussive effect, can control lymphoid tuberculosis, neuralgia, chronic arthritis, lump in breast.Salty in the mouth, cold.Slightly poisonous.Cure mainly and dispel the wind, active, eliminating stagnation.Be used for paralysis due to windstroke, rheumatic arthritis, osteomyelitis, tuberculous lymphadenitis, tumor.Be the good medicine of treatment breast tumor.

Flos Carthami is warm in nature, acrid in the mouth.Function cures mainly and is applied to invigorate blood circulation latus rectum, eliminating stasis to stop pain.Be used for that amenorrhea, dysmenorrhea, lochia are not all right, lump in the abdomen mass in the abdomen, traumatic injury." book on Chinese herbal medicine converges and says ": Flos Carthami, the medicine of removing blood stasis, promoting the circulation of blood and blood, accent blood also.Main tire produces all kinds of diseases and ailments and is trouble because of blood, or the tired bruise of blood, and coma in silence; Or lochia is robbed the heart, the umbilicus angina abdominis; Or the drop slurry is difficult living; Or afterbirth do not fall, and dead fetus in the uterus is all just before giving birth all cards, and non-Flos Carthami can not be controlled.If puerperal blood faints, locked mouth refer to hold in the hand; Or heresy goes into the blood chamber, and delirium is gone mad; Or blood expands in vexed, and the sudden syncope with rigidity is as extremely, be all puerperal all cards, non-Flos Carthami can not be decided.All friendship as the obstructed and cold and heat of amenorrhea done, or expired stomachache and purple black dripping, or injury from falling down and the QI and blood stasis of blood is long-pending, or skin infection sufferings and swollenly burst uneasyly, is cards of disharmony between QI and blood all, and non-Flos Carthami can not be transferred.

Oletum Trogopterori is the feces of Mammalia, flying squirrel section animal trogopterus xanthipes Milne-Edwards (cold number bird), flying squirrel or other nearly edge animal.Oletum Trogopterori is sweet in flavor and warm in property, and is nontoxic, goes into Liver Channel, has the mediation blood vessels, the effect of eliminating stasis to stop pain; It is gynecological's key medicine.Cure mainly stasis, amenorrhea, stomachache; Diseases such as breast side of body twinge tumbling and swelling and snake bite and insect sting.It is logical that the Oletum Trogopterori hardship is let out temperature, and " tonneau gaseous pulse ", " general rule is not bitterly." " the stasis passages through which vital energy circulates, gas must not be gone, and attacks cards such as thorn pain, must use in institute so " Bencao Jingshu " calls it." " detailed outline " carry: Oletum Trogopterori, liver channel of foot-Jueyin medicine also, abnormal smells from the patient is all thick, the yin aspect of yin is so go into blood system.Liver master blood so medicine can be controlled disorders of blood, looses blood and blood and ends all pains.End and remove malaria dysentery, removing food stagnancy reduces phlegm, and treats the infantile malnutrition parasite killing, controls arthralgia due to stagnation of blood, all diseases of blood eye, all belongs to Liver Channel also.

The Myrrha blood blood stasis removing that looses, subduing swelling and relieving pain.Cure mainly traumatic injury, incised wound, muscles and bones, all pains of trusted subordinate, lump in the abdomen, amenorrhea, ulcer sore pain, anal fistula, diseases of the eye.Bitter in the mouth, suffering, flat.Go into liver, spleen, the heart, kidney channel." Bencao Jingshu " carries it: " the ulna arthralgia is coerced costalgia with husband's breast abdomen, non-retention of blood stasis and because of using in blood deficiency person.Lochia goes many, and empty pain person should not use in the abdomen.Carbuncle has been burst and should not have been used.The non-heat in blood of conjunctival congestion skin nebula very person should not be used." join Olibanum, promoting blood circulation to remove blood stasis, circulation of qi promoting Shujin.

The Olibanum regulating QI is invigorated blood circulation, and pain relieving chases after poison, controls coagulation of QI-blood, trusted subordinate's pain, carbuncle pyogenic infections from tumour or sore, traumatic injury, dysmenorrhea, postnatal blood stasis twinge.Supplement to the Herbal carries it: " treat deaf, the apoplexy locked mouth, married woman's vim and vigour can be sent out wine, manage air-cooledly, only is large intestine let out?, treat all skin ulcers and make internal diabetes.”

The Resina garciniae detumescence, removing toxic substances, hemostasis, parasite killing.Control swollen ulcer drug, stubborn dermatitis malignant boil, bleeding due to trauma, ulcerative gingivitis decayed tooth, burn.Resina garciniae has stronger bacteriostasis to staphylococcus aureus, and alcoholic solution has strong bacteriostasis to bacillus pyocyaneus.Gamlogic acid shows stronger anti-tumor activity to kinds of tumors, and toxic and side effects is smaller in effective dosage ranges, inhibition to tumor cell has very high selectivity, kill cancer cell optionally, and to intact animal's hemopoietic system and not influence of immunologic function, this is that present tumor chemotherapeutic drug is not available.Pharmacokinetic also shows that gamlogic acid has higher distribution and long persistent period in tumor tissues.Gamlogic acid is the broad-spectrum anti-tumor medicine, and kinds of tumors is had significant curative effect.

A kind of Chinese medicine material of Flos Campsis has promoting the circulation of blood blood stasis removing, cooling blood, expelling wind dampness removing, heat-clearing and toxic substances removing, and acrid in the mouth acid, cold nature is returned liver, pericardium channel, function promoting blood circulation to remove blood stasis, cooling blood, expelling wind.Cure mainly menoxenia, amenorrhea lump in the abdomen, puerperal swelling of the breast, skin pruritus. " Amplification on Materia Medica addendum ": Flos Campsis, the key medicine of controlling pain in the blood also, and the nourishing YIN victory is very, is stamped to keep and walk alone, and is many with what in the married woman side." Nanning City's medicine will ": the merit of eliminating inflammation and expelling toxin, hemostasis and pain-relieving, evacuation of pus granulation promoting is arranged, control red Hakuri.

The Herba Patriniae nature and flavor are bitter flat, have the effect of heat-clearing and toxic substances removing, evacuation of pus removing blood stasis with potent drugs.Can cure acute appendicitis, dysentery, leucorrhea with red and white discharge, the stagnant stomachache of the stasis of blood in puerperal, conjunctival congestion and swelling pain.Go into stomach, large intestine, Liver Channel.Cure mainly heat-clearing and toxic substances removing, eliminating carbuncle evacuation of pus, blood circulation promoting competent silt.Be used for acute appendicitis, lung abscess and sore and toxic, the breast abdomen pain due to the excess-heat stasis of blood stagnates, the stagnant stomachache of the stasis of blood in puerperal waits disease.

Motherland's medical science thinks that breast belongs to stomach on the meridians route distributes, and nipple belongs to liver.The lid liver is general's official, and property happiness bar reaches, as is subjected to direct stimulation, and the stagnation of QI is lost and dredged, and perverse and unreasonable manner is violated stomach, the resistance of stagnation of liver-QI stomach, and the pathogens agglomerating meridians form " mastopathia ".Because conception vessel and Liver Channel are closely related, two through going together and lower abdomen, and some acupuncture points on the human body of conception vessel such as Qugu, the middle utmost point, cv etc. are all met with Liver Channel.When through water in the future in, abundance of blood in CHONG meridian, resembling of Liver Channel stasis is more outstanding, on then see uncomfortable in chest, mammary swelling pain, nextly see lower abdominal distention pain.After water came, the sea of blood was empty temporarily, and stagnation of liver-QI is alleviated, so mammary swelling abdominal distention is also flat.So periodically outbreak repeatedly, then the breast caking does not loose, and pain exacerbates, and the growth and decline with susceptible to anger.Therefore many medicine conditionings with the silt of activeization of soothing liver-QI.Rhizoma Arisaematis is dispelled, and swelling looses becomes silted up; Rhizoma Drynariae soothing liver-QI collateral dredging; The pain relieving of Radix Paeoniae Rubra clearing away heat and cooling blood; Caulis Spatholobi, the Flos Campsis regulating menstruation and nourishing blood; Flos Carthami silt promoting the circulation of blood detumescence, Oletum Trogopterori, Gekko Swinhonis Gekko Swinhonis all are the mastotic good medicine good merchantable brands of treatment; The Herba Taraxaci heat radiation detumescence poison of dispelling, it all is surgery good medicine that the Borneolum Syntheticum detumescence is invigorated blood circulation.

Rhizoma Arisaematis has the effect of expelling wind for relieving convulsion, dispersing swelling and dissipating binds.Bitter, hot, temperature; Poisonous.Return lung, liver, spleen channel." Kaibao Bencao " carries it: main apoplexy, and expectorant, paralysis, the therapeutic method to keep the adverse QI flowing downwards, broken hard long-pending, subduing inflammation, sharp chest and diaphragm, the blood induced abortion of loosing.A small amount of utilization surgery can be dispelled, and swelling looses becomes silted up.

The Rhizoma Drynariae hardship, temperature.Return kidney, Liver Channel.Function the kidney invigorating bone strengthening continues and hinders pain relieving.Be used for lumbago due to renal deficiency, Hiccough and deaf, odontoseisis, falling winks frustrates, and the muscles and bones folding is hindered; The external treatment alopecia areata, vitiligo." Japan hanako materia medica " carries it: control malignant boil, the mashed meat of erosion, parasite killing.Be that surgery is used for tumor good medicine.

The Radix Paeoniae Rubra bitter in the mouth is slightly cold.Return Liver Channel.Function cures mainly clearing away heat and cooling blood, eliminating stasis to stop pain.Be used for maculae caused by violent heat pathogen, hematemesis and epistaxis, conjunctival congestion and swelling pain, hypochondriac pain due to stagnation of liverQI, amenorrhea dysmenorrhea, lump in the abdomen stomachache, injury from falling down, carbuncle skin infection.The Radix Paeoniae Rubra branch excess-heat that can purify the blood, dissipating blood stasis blood is detained.This product function and Cortex Moutan are close, so normal be usefulness with the Cortex Moutan mutual reinforcement between.But the effect of Cortex Moutan clearing away heat and cooling blood is preferable, and the branch excess-heat that can purify the blood can be controlled fever due to yin deficiency again; And Radix Paeoniae Rubra can only be used for the blood system excess-heat, is good at promoting blood circulation to remove blood stasis.

Caulis Spatholobi property hardship, sweet, temperature.Return liver, kidney channel, enrich blood, invigorate blood circulation, collateral dredging.Be used for menoxenia, blood deficiency and yellow complexion, paralysis and numbness, rheumatic arthralgia relaxing muscles and tendons to promote blood circulation; Nourishing blood for regulating menstruation, supplementary Amplifications of the Compendium of Materia Medica carry it can cure numb hand and foot; Quadriplegia; Rheumatic arthralgia; The women has through uncomfortable; Dysmenorrhea.

Herba Taraxaci is a Chinese medicine commonly used simply, and its medical value is loaded various medical books early.Its all herbal medicine contains compositions such as taraxasterol, taraxerol, taraxacin, caffeic acid, choline, inulin.The flat sweet and slightly bitter taste of property.But heat-clearing and toxic substances removing, dispersing swelling and dissipating binds.Compendium of Material Medica record: " Detoxicating food-poisoning, the gas that stagnates that looses, the heat clearing away poison, the relieving dyspepsia poison, disappear dislike swollen, tuberculosis, furuncle is swollen.”。Herba Taraxaci is hidden sweet flat, and its property is nontoxic.When being goes into stomach into liver, the key medicine of analgesic removing heat from blood.

The Radix Salviae Miltiorrhizae hardship is slightly cold.GUIXIN, Liver Channel.Stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, relieving restlessness clears away heart-fire.Be used for menoxenia, the amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia.Be used for the costa sternales hypochondriac pain, rheumatic arthralgia, lump in the abdomen caking, skin infection swells and ache, the tumbling down pain of injury, menoxenia, the amenorrhea dysmenorrhea, puerperal stasis of blood pain etc.Treatment costa sternales pain, lump in the abdomen caking, and menoxenia, amenorrhea dysmenorrhoea have good effect." detailed outline " carries: Radix Salviae Miltiorrhizae, by " the sensible opinion of married woman " cloud, SIWU TANG is controlled the gynecopathy, pays no attention to antenatal puerperal, through water what, all can be general, only flavor Radix Salviae Miltiorrhizae looses, and cures mainly identical with it.The lid Radix Salviae Miltiorrhizae can break stagnated blood, mends fresh blood, peaceful tire, and the stillborn fetus that falls ends the metrorrhagia dysentery, the regulating menstruation arteries and veins.

Oletum Trogopterori is the feces of Mammalia, flying squirrel section animal trogopterus xanthipes Milne-Edwards, flying squirrel or other nearly edge animal.Oletum Trogopterori is sweet in flavor and warm in property, and is nontoxic, goes into Liver Channel, has the mediation blood vessels, the effect of eliminating stasis to stop pain; It is gynecological's key medicine.Cure mainly stasis, amenorrhea, stomachache; Diseases such as breast side of body twinge tumbling and swelling and snake bite and insect sting.It is logical that the Oletum Trogopterori hardship is let out temperature, and " tonneau gaseous pulse ", " general rule is not bitterly." " the stasis passages through which vital energy circulates, gas must not be gone, and attacks cards such as thorn pain, must use in institute so " Bencao Jingshu " calls it." " detailed outline " carry: Oletum Trogopterori, liver channel of foot-Jueyin medicine also, abnormal smells from the patient is all thick, the yin aspect of yin is so go into blood system.Liver master blood so medicine can be controlled disorders of blood, looses blood and blood and ends all pains.End and remove malaria dysentery, removing food stagnancy reduces phlegm, and treats the infantile malnutrition parasite killing, controls arthralgia due to stagnation of blood, all diseases of blood eye, all belongs to Liver Channel also.It is the panacea of treatment mastopathy.

Gekko Swinhonis goes the dry products of internal organs to go into Chinese medicine, and name " Gekko Swinhonis Gekko Swinhonis " has tonifying the lung kidney, benefiting essence-blood, relieving cough and relieving asthma, spasmolytic to dispel the wind and disperses the repercussive effect, can control lymphoid tuberculosis, neuralgia, chronic arthritis, lump in breast.Salty in the mouth, cold.Slightly poisonous.Cure mainly and dispel the wind, active, eliminating stagnation.Be used for paralysis due to windstroke, rheumatic arthritis, osteomyelitis, tuberculous lymphadenitis, tumor.It also is the treatment breast disease that Gekko Swinhonis Gekko Swinhonis is used for surgery, the good medicine of anti-tumor disease.

Borneolum Syntheticum is used for conjunctival congestion and swelling pain, the sore throat aphtha.The Borneolum Syntheticum bitter cold has the merit of clearing away heat to alleviate pain, detumescence, is department of eye medicine commonly used.Treatment laryngopharynx swelling and pain, aphtha of the mouth and tongue, normal and Borax, Cinnabaris, Matrii Sulfas Exsiccatus grind to the powder altogether, blow deposited affected part, as BINGPENG SAN.The treatment acute pharyngitis due to wind-heat is used for skin infection and swells and ache, and does not hold back after bursting.This product also has heat-clearing and toxic substances removing, erosion prevention and muscle growing effect.It is the good medicine good merchantable brand of surgery.

The preparation method that the present invention treats cyclomastopathy and antineoplastic Chinese medicine composition comprises: the preparation method when the endo-medicine dosage form is capsule is made up of following steps:

Gekko Swinhonis Gekko Swinhonis 2000g is earlier through 85% above ethanol extraction 3 times, promptly use soak with ethanol, 80～90 ℃ of heat are extracted, time was respectively 2 hours, 1 hour, 1 hour, the weight ratio of used ethanol and Gekko Swinhonis Gekko Swinhonis is respectively: for the first time be 10 times of amounts, the second time are 6 times of amounts, be 6 times of amounts for the third time, merge the ethanol extract after the immersion three times, reclaim ethanol then, the medicinal liquid stand for standby use after concentrating; Residue and other drug merge, water is carried 3 times, be that decocting boils, 80～100 ℃, time were respectively 2 hours, 1.5 hours, 1 hour, the weight ratio of institute's water and residue and other drug gross weight is respectively: for the first time be 10 times of amounts, the second time are 8 times of amounts, be 6 times of amounts for the third time, the water extract that extracts three times merges, and concentrates (being concentrated into relative density is 1.08); With water extract and the merging of ethanol concentrated medicament, filtration, spray drying, granulation, encapsulated again.

The preparation method that the present invention treats cyclomastopathy and antineoplastic Chinese medicine composition comprises: the external used medicine preparation method is made up of following steps:

With Gekko Swinhonis Gekko Swinhonis 2000g, Rhizoma Arisaematis 300g puts into 85% above ethanol extraction 1 time.Promptly use soak with ethanol, 85 ℃ of heat are extracted, and the time is more than 3 hours.Reclaim ethanol then, the medicinal liquid stand for standby use after the filtering and concentrating; Residue and other drug merge, Radix Salviae Miltiorrhizae 3000g, Rhizoma Drynariae 3000g, Flos Campsis 3000g, Caulis Spatholobi 3000g, Radix Paeoniae Rubra 3000g, Flos Carthami 3000g, Oletum Trogopterori 3000g, Herba Taraxaci 3000g, Borneolum Syntheticum 3000g, remove Borneolum Syntheticum and added the water logging bubble 45 minutes, heating was boiled 35 minutes, filtered filtrate for later use; Filtering residue adds water and heats for the second time, boils 25 minutes, filters; Three filtrates are lumped together, and heating is concentrated into pasty state, puts into the mixed fine-powdered that grinds to form of baking oven 80 ℃ of oven dry postcooling and Borneolum Syntheticum; Mixed then vaseline furnishing pasty state spreads out on oilpaper, sticks the breast tumor place and gets final product.

The preparation method of topical agent of the present invention can also be following steps:

Patient's wash clean patient part pasted potion breast of the present invention and was affixed on the affected part every night, took off after 24 hours to get final product.The agent of external of the present invention card can 7 days is to use a course of treatment, and is difficult for pollution clothes, easy to use, quick.

This Chinese medicine composition kidney tonifying tonify deficiency, nourishing blood and promoting blood circulation, treating both the principal and secondary aspects of a disease improves immunity of human body itself, nervous system regulation, the activating blood circulation to dissipate blood stasis eliminating stagnation does not produce any side effect to human body, and is safe and effective; External used medicine can be at the diseased region direct drug injection, through focus, and targeting is strong, and promoting blood circulation to remove blood stasis has no side effect, and medicine can be infiltrated rapidly make skin absorbs, and instant effect, and therapeutic effect is good, and is with low cost, reparation technology is simple and easy to do.

Pharmacology's toxicity test

1. skin irritation test

Get rabbit and shave hair, induce and excite contact test with external used medicine breast patch of the present invention, viewing test rabbit after 24 hours and 48 hours, all loseing skin has phenomenons such as erythema and edema, with the negative control group zero difference.The result shows that this patch is bordering on zero to dermoreaction intensity, does not promptly have skin allergic reaction.

2. endo-medicine cumulative toxicity test report

Test method: select 20 healthy mices for use, female, male each 10, dosage designs per 5 days and is first phase, each issue dosage is respectively 0.10LD50,0.15LD50,0.22LD50,0.34LD50,0.50LD50, and the LD50 female, male mice of this sample is 5000m part/k part BW (five dosage be 500,750,1100,1700,2500m part/k part BW).Weighed once in per 5 days, and adjusted dosage, press 0.1ml/10 part BW per os and irritate stomach.After 20 days, animal does not have death condition takes place, and off-test is tried thing after 20 days by ascending-dose, and female, buck does not all have death condition and takes place.

3. acute toxicity test

Give the white mouse oral administration medicine supplying with 300 times of the clinical consumption per day of this product endo-medicine, observed 5.All animals are strong as a result deposits, and its activity, diet, hair, Excreta are no abnormal, do not see toxic reaction.The white mouse damaged skin is carried out irritation test, and not seeing has irritative response and other untoward reaction.

Toxicity test proves, not toxic effect of this medicine and untoward reaction, and clinical practice is safe and reliable.

Embodiment 1: the Qin, and the woman, 36 years old, main suit during prescription on individual diagnosis: distending pain of the breast 2 years, increase the weight of March.The bilateral distending pain of the breast appearred in the patient before 2 years, attaches most importance to before the You Yijing, and menstruation menostaxis usually, 45-50d delegation, amount is many, and clot is arranged, with lower abdomen pain.Once checked at outer court's row molybdenum target, be diagnosed as cyclomastopathy.Once external Chinese medicine for oral administration treatment, symptom slightly alleviates, but increases the weight of when meeting anxious state of mind.Again because of angry self-induction distending pain of the breast increases the weight of, can not touch clothing when serious before March.The patient is reluctant to accept the doctor trained in Western medicine operative treatment, and check: two breasts are gone up quadrant outward can touch granular substance.Ultrasound diagnosis prompting: two cyclomastopathy.The patient companion sees singultus, and the right side of body of sense sometimes is dull pain down.The dimly red tongue tongue is white, stringy and thready pulse.Tcm diagnosis: nodules of the breast.Western medicine diagnose: two cyclomastopathy.Chinese medical discrimination belongs to stagnation of QI due to depression of the liver, blockage of main and collateral channels.Control with depressed liver-energy dispersing and QI regulating activating collaterals and eliminating stagnation.Use following Drug therapy:

Endo-medicine is: Radix Bupleuri 10g, Radix Codonopsis 15g, Radix Astragali 15g, Radix Angelicae Sinensis 15g, Flos Albiziae 15g, Spica Prunellae 15g, Folium Perillae 15g, Radix Paeoniae Alba 10g, Flos Campsis 15g, Herba Patriniae 15g, Gekko Swinhonis Gekko Swinhonis 10g, Flos Carthami 20g, Fructus Lycii 20g, Oletum Trogopterori 20g, Myrrha 15g, Olibanum 20g, Resina garciniae 20g;

External used medicine is: Rhizoma Arisaematis 6g, Radix Salviae Miltiorrhizae 15g, Rhizoma Drynariae 20g, Flos Campsis 15g, Caulis Spatholobi 15g, Radix Paeoniae Rubra 15g, Flos Carthami 20g, Oletum Trogopterori 20g, Gekko Swinhonis Gekko Swinhonis 10g, Herba Taraxaci 20g, Borneolum Syntheticum 20g.

Continued treatment March, clinical symptom disappearance, menstruation recovery is normal.Check B ultrasonic lesions showed disappears.Follow up a case by regular visits to and do not have recurrence.

Embodiment 2: the gold certain, the woman, 30 years old, married.The cause often has the thing that has some setbacks during prescription on individual diagnosis, is in for a long time among the worry, and it is surplus often to feel right breast portion pain 1 year, and nearly February, distension pain was also felt by left breast portion, whenever with the menstrual cycle outbreak, nearly two weeks are usually also felt pain, and companion's menstruation is delayed, the few color of amount secretly has piece, and the sagging distention in the smaller abdomen pain can not be adhered to working.Breast portion palpation: lay one's hand on and a plurality of lump not of uniform size on the breast right side, round, as the egg size, and the tuberosity that matter is tough, obscure boundary, some can move, and tenderness is not obvious, and the left side is little tenderness, can lay one's hand on and enclosed mass.Through ultrasound diagnosis: quadrant is visited and size is respectively the low echo-level mass of 5.8 * 5.7 * 5.6cm and the low echo-level mass of 2.1 * 2.0 * 1.5cm outside the right mammary gland; Mammary gland outer quadrant in a left side is visited and 0.9 * 0.8 * 0.5cm low echo-level mass.Be diagnosed as bilateral breast cystic hyperplasia disease and cyclomastopathy.The patient before 1 year once in the clothes, Western medicine and patent medicine (XIAOHE PIAN, BAIXIAO DAN etc.), curative effect does not show, and unstable, prepare to go surgery to operate, after have misgivings to have no resolution.Disease sees that god withers, fatigue and weakness, and dizzy insomnia, poor appetite, vexed, bitter taste, purple dark, the yellow and thin fur of light red tongue, limit, stringy pulse is slow slightly counts accurately.Dialectically be the stagnation of liver-QI blood stasis Chong and Ren channel disorder of holding concurrently, in order to Drug therapy down:

Endo-medicine is: Radix Bupleuri 20g, Radix Codonopsis 20g, Radix Astragali 20g, Radix Angelicae Sinensis 15g, Flos Albiziae 15g, Spica Prunellae 20g, Folium Perillae 15g, Radix Paeoniae Alba 15g, Flos Campsis 20g, Herba Patriniae 20g, Gekko Swinhonis Gekko Swinhonis 10g, Flos Carthami 15g, Fructus Lycii 15g, Oletum Trogopterori 15g, Myrrha 15g, Olibanum 10g, Resina garciniae 15g;

External used medicine is: Rhizoma Arisaematis 10g, Radix Salviae Miltiorrhizae 20g, Rhizoma Drynariae 25g, Flos Campsis 25g, Caulis Spatholobi 25g, Radix Paeoniae Rubra 20g, Flos Carthami 20g, Oletum Trogopterori 20g, Gekko Swinhonis Gekko Swinhonis 10g, Herba Taraxaci 25g, Borneolum Syntheticum 20g.

The patient obeys 1 dose every day, 1d clothes 2 times, and advise careful disgruntled, regulating spirit and emotion by oneself.After obeying 10 doses, the newborn pain relief in a left side of patient's self-induction, right mastalgia also alleviates, and appetite is normal, braces up, and still can sleep, and all diseases are clearly better.After continuing 20 doses of defence clothes again, right mastalgia disappears, but some sense of expanding of pressing, the right newborn portion of ultrasound diagnosis enclosed mass reduces to and is respectively 2.1 * 1.9 * 1.6cm and 0.3 * 0.2 * 0.1cm, and menstruation this time also comes at the appointed time, and red menses is not seen piece, and lower abdomen is not bitterly.Defence clothes are after March again, symptom complete obiteration, breast portion palpation no abnormality seen, ultrasound diagnosis, right breast portion no abnormality seen.Follow up a case by regular visits to not recurrence in 1 year.

Embodiment 3: Lee, woman, 38 years old.The patient was not relaxed because of family matters discord causes feelings will before half a year, and the aftersensation right breast is had a pain, and is gradually heavy, and once in the diagnosis and treatment of hospital general, oil field, examined and be cyclomastopathy before January, clothes Western medicine and Chinese medicine ease pill etc., poor effect is so come here to seek medical advice.Card sees that body is plentiful, and there are 1 lump such as ovum gallinaceum in the outer top of right breast, the pain of pressing very, smooth surface, the movability that pushes away, dimly red tongue, yellow, greasy and thin fur.Wiry and frequent pulse, Chinese medical discrimination are stagnation of QI due to depression of the liver, and expectorant heat stagnates, and meridians are not smooth, and qi and blood stagnation is in breast.Control with depressed liver-energy dispersing and QI regulating dissipating phlegm and resolving masses, eliminating blood stasis and smoothing collaterals.Use following Drug therapy:

Endo-medicine is: Radix Bupleuri 25g, Radix Codonopsis 25g, Radix Astragali 30g, Radix Angelicae Sinensis 30g, Flos Albiziae 20g, Spica Prunellae 30g, Folium Perillae 25g, Radix Paeoniae Alba 20g, Flos Campsis 25g, Herba Patriniae 25g, Gekko Swinhonis Gekko Swinhonis 20g, Flos Carthami 30g, Fructus Lycii 25g, Oletum Trogopterori 30g, Myrrha 30g, Olibanum 25g, Resina garciniae 30g;

External used medicine is: Rhizoma Arisaematis 8g, Radix Salviae Miltiorrhizae 30g, Rhizoma Drynariae 30g, Flos Campsis 30g, Caulis Spatholobi 20g, Radix Paeoniae Rubra 15g, Flos Carthami 30g, Oletum Trogopterori 30g, Gekko Swinhonis Gekko Swinhonis 20g, Herba Taraxaci 15g, Borneolum Syntheticum 15g.

15 doses of oral medicine, external 20 is pasted, and lump is subdued half, and pain subtracts greatly, obeys 30 doses again, and external 35 is pasted.All cards disappear, and sick the announcement fully recovered.Follow up a case by regular visits to and do not have recurrence.

Embodiment 4: Lin, and the woman, 27 years old, married, pregnant 2 produced 1 artificial abortion 1, the existing ring of going up, the patient found left swelling of the breast piece during the unit health check-up before March, did not add attention.The bimastism distending pain appears before this menstrual onset, the more preceding increase of left swelling of the breast piece, and the dragging pain sense is arranged.Obvious through the fore udder distending pain, through after do not slow and separate, dysmenorrhea is delayed in companion's menstruation, clot increases, lumbago is as folding, feeling of fullness and disecomfort in the chest and hypochondrium, irritated irritability, dry mouth with bitter taste, it is poor that poor appetite is slept, body of the tongue is light red, the tip of the tongue is dark red, thin lingual fur Huang slightly, the strawberry-like point is arranged, stringy and hesitant pulse.Have a medical check-up: two nipple symmetries do not have depression and discharge, and skin does not have redness, and no projection, left breast go up quadrant outward has 3 places to be graininess and streak lump, matter is harder, and is unclear with the surrounding tissue boundary, the no adhesion of the activity that pushes away, touch a tender spot obviously right breast (), the no enlargement of bilateral axillary lymph knot.Show through the inspection of near infrared ray mammary gland instrument: two newborn blood vessels increase slightly and increase, visible cloud light gray shadow uniformly, and left breast goes up the visible 3 place's worm-eaten shaped laser spots of quadrant outward, be middle ghost, size 0.5 * 0.8cm, 1.5 * 1.5cm, 1.8 * 2.4cm, printing opacity is inhomogeneous, no abnormality seen blood vessel companion row.Be diagnosed as: bilateral breast cystic hyperplasia (left side breast for very).The traditional Chinese medical science is examined and is nodules of the breast, and dialectical is syndrome of qi stagnation and blood stasis, controls based on dispersing the stagnated live-QI to relieve the stagnation of QI, and blood circulation promoting and blood stasis dispelling is auxilliary, in order to descend Drug therapy:

Endo-medicine is: Radix Bupleuri 20g part, Radix Codonopsis 30g, Radix Astragali 30g, Radix Angelicae Sinensis 30g, Flos Albiziae 30g, Spica Prunellae 30g, Folium Perillae 30g, Radix Paeoniae Alba 20g, Flos Campsis 20g, Herba Patriniae 20g, Gekko Swinhonis Gekko Swinhonis 15g, Flos Carthami 20g, Fructus Lycii 15g, Oletum Trogopterori 30g, Myrrha 10g, Olibanum 30g, Resina garciniae 30g;

External used medicine is: Rhizoma Arisaematis 6g, Radix Salviae Miltiorrhizae 30g, Rhizoma Drynariae 20g, Flos Campsis 30g, Caulis Spatholobi 20g, Radix Paeoniae Rubra 20g, Flos Carthami 30g, Oletum Trogopterori 20g, Gekko Swinhonis Gekko Swinhonis 15g, Herba Taraxaci 30g, Borneolum Syntheticum 20g.

Conscious distending pain of the breast is obviously alleviated after obeying 15 doses, the lump deliquescing is dwindled, after using February, subjective symptoms disappears, lump be difficult for laying one's hand on and, advise continuous clothes infrared breast examination after 2 months: bilateral breast blood vessel moves towards nature, do not see increase slightly tortuous, two newborn printing opacities are more preceding good, resemble gland on left mammary gland is outer and do not see obvious worm-eaten shaped laser spot.The infrared mammary gland of check shows after half a year: two breasts are normal.Follow up a case by regular visits to and do not see recurrence in 1 year.

In clinical practice earlier with all cases through near infrared ray, other mastopathy has been got rid of in inspections such as B ultrasonic, the precedence random packet of going to a doctor by the patient, totally 120 examples, 18～55 years old age, average 34 years old; Unmarried 36 examples, married 84 examples; The course of disease 1 month～10 years, average 60.5 months; The person's of not performing a surgical operation 95 examples, the excision of once performing a surgical operation, then recidivist's 25 examples again; Syndrome of blood stasis 50 examples wherein, syndrome of stagnation of QI 46 examples, expectorant is demonstrate,proved 24 examples with fixed attention, one-sided 30 examples, bilateral 90 examples.Through the present invention's treatment, produce effects 112 examples, DeGrain 3 examples, invalid 5 examples, total effective rate 93.3%.

Claims

1, a kind of treatment cyclomastopathy and antineoplastic Chinese medicine composition is characterized in that, form by endo-medicine and external used medicine,

The ratio of weight and number of various components is in the described endo-medicine: 10～30 parts of Radix Bupleuri, 10～30 parts of Radix Codonopsis, 10～30 parts of the Radixs Astragali, 10～30 parts of Radix Angelicae Sinensis, 10～30 parts of Flos Albiziaes, 10～30 parts of Spica Prunellaes, 10～30 parts of Folium Perillaes, 10～30 parts of the Radix Paeoniae Albas, 10～30 parts of Flos Campsiss, 10～30 parts of Herba Patriniae, 10～20 parts of Gekko Swinhonis Gekko Swinhonis, 10～30 parts on Flos Carthami, 10～30 parts of Fructus Lycii, 10～30 parts of Oletum Trogopteroris, 10～30 parts of Myrrhas, 10～30 parts of Olibanums, 10～30 parts of Resina garciniaes;

2, according to described treatment cyclomastopathy of claim 1 and antineoplastic Chinese medicine composition, it is characterized in that, the ratio of weight and number of various components is in the described endo-medicine: 10～15 parts of Radix Bupleuri, 10～15 parts of Radix Codonopsis, 10～15 parts of the Radixs Astragali, 10～15 parts of Radix Angelicae Sinensis, 10～15 parts of Flos Albiziaes, 10～15 parts of Spica Prunellaes, 10～15 parts of Folium Perillaes, 10～15 parts of the Radix Paeoniae Albas, 10～15 parts of Flos Campsiss, 10～15 parts of Herba Patriniae, 10～15 parts of Gekko Swinhonis Gekko Swinhonis, 15～20 parts on Flos Carthami, 15～20 parts of Fructus Lycii, 15～20 parts of Oletum Trogopteroris, 15～20 parts of Myrrhas, 15～20 parts of Olibanums, 15～20 parts of Resina garciniaes;

The ratio of weight and number of various components is in the described external used medicine: 3～7 parts of Rhizoma Arisaematiss, 15～20 parts of Radix Salviae Miltiorrhizaes, 15～20 parts of Rhizoma Drynariae, 15～20 parts of Flos Campsiss, 15～20 parts of Caulis Spatholobis, 15～20 parts of Radix Paeoniae Rubra, 15～20 parts on Flos Carthami, 15～20 parts of Oletum Trogopteroris, 10～15 parts of Gekko Swinhonis Gekko Swinhonis, 15～20 parts of Herba Taraxacis, 15～20 parts of Borneolum Syntheticums.

3, according to described treatment cyclomastopathy of claim 1 and antineoplastic Chinese medicine composition, it is characterized in that, the ratio of weight and number of various components is in the described endo-medicine: 15～20 parts of Radix Bupleuri, 15～20 parts of Radix Codonopsis, 15～20 parts of the Radixs Astragali, 15～20 parts of Radix Angelicae Sinensis, 15～20 parts of Flos Albiziaes, 15～20 parts of Spica Prunellaes, 15～20 parts of Folium Perillaes, 15～20 parts of the Radix Paeoniae Albas, 15～20 parts of Flos Campsiss, 15～20 parts of Herba Patriniae, 10～15 parts of Gekko Swinhonis Gekko Swinhonis, 10～15 parts on Flos Carthami, 10～15 parts of Fructus Lycii, 10～15 parts of Oletum Trogopteroris, 10～15 parts of Myrrhas, 10～15 parts of Olibanums, 10～15 parts of Resina garciniaes;

The ratio of weight and number of various components is in the described external used medicine: 4～8 parts of Rhizoma Arisaematiss, 20～25 parts of Radix Salviae Miltiorrhizaes, 20～25 parts of Rhizoma Drynariae, 20～25 parts of Flos Campsiss, 20～25 parts of Caulis Spatholobis, 20～25 parts of Radix Paeoniae Rubra, 20～25 parts on Flos Carthami, 20～25 parts of Oletum Trogopteroris, 15～20 parts of Gekko Swinhonis Gekko Swinhonis, 20～25 parts of Herba Taraxacis, 20～25 parts of Borneolum Syntheticums.

4, according to described treatment cyclomastopathy of claim 1 and antineoplastic Chinese medicine composition, it is characterized in that, the ratio of weight and number of various components is in the described endo-medicine: 25～30 parts of Radix Bupleuri, 25～30 parts of Radix Codonopsis, 25～30 parts of the Radixs Astragali, 25～30 parts of Radix Angelicae Sinensis, 25～30 parts of Flos Albiziaes, 25～30 parts of Spica Prunellaes, 25～30 parts of Folium Perillaes, 25～30 parts of the Radix Paeoniae Albas, 25～30 parts of Flos Campsiss, 25～30 parts of Herba Patriniae, 15～20 parts of Gekko Swinhonis Gekko Swinhonis, 25～30 parts on Flos Carthami, 25～30 parts of Fructus Lycii, 25～30 parts of Oletum Trogopteroris, 25～30 parts of Myrrhas, 25～30 parts of Olibanums, 25～30 parts of Resina garciniaes;

The ratio of weight and number of various components is in the described external used medicine: 5～9 parts of Rhizoma Arisaematiss, 15～30 parts of Radix Salviae Miltiorrhizaes, 15～30 parts of Rhizoma Drynariae, 15～30 parts of Flos Campsiss, 15～30 parts of Caulis Spatholobis, 15～30 parts of Radix Paeoniae Rubra, 15～30 parts on Flos Carthami, 15～30 parts of Oletum Trogopteroris, 15～20 parts of Gekko Swinhonis Gekko Swinhonis, 15～30 parts of Herba Taraxacis, 15～30 parts of Borneolum Syntheticums.

According to each described treatment cyclomastopathy and antineoplastic Chinese medicine composition in the claim 1～4, it is characterized in that 5, the endo-medicine of described Chinese medicine composition is fried in shallow oil decoction in use and taken, 1 dose of every day, decocting is obeyed at twice, and per 7 days is a course of treatment.

6, according to each described treatment cyclomastopathy and antineoplastic Chinese medicine composition in the claim 1～4, it is characterized in that described endo-medicine dosage form is: honey refining pill, hydration pill, capsule, oral liquid, granule, colloid or syrup.

7, according to each described treatment cyclomastopathy and antineoplastic Chinese medicine composition in the claim 1～4, it is characterized in that described endo-medicine dosage form is tablet or powder, when taking, one day three times, per 7 days is a course of treatment.

8, a kind ofly it is characterized in that as the preparation method of treatment cyclomastopathy and antineoplastic Chinese medicine composition as described in each in the claim 1～4 described endo-medicine dosage form is a capsule, its preparation method comprises:

9, a kind of as the preparation method of treatment cyclomastopathy and antineoplastic Chinese medicine composition as described in each in the claim 1～4, it is characterized in that the preparation of described external used medicine may further comprise the steps:

Gekko Swinhonis Gekko Swinhonis and Rhizoma Arisaematis put into 80～90 ℃ of heat of ethanol of 85% and extracted 2 hours, filtering and concentrating is stand for standby use behind 1.08 the concentrated solution to relative density; Aforementioned residue and other described components merge, and remove Borneolum Syntheticum and add the water logging bubble 30 minutes to 1 hour, and heating was boiled 30～40 minutes, filtered filtrate for later use; Filtering residue adds water and heats for the second time, boils 20～30 minutes, filters; Three filtrates are lumped together, and heating is concentrated into pasty state, puts into the mixed fine-powdered that grinds to form of baking oven 80 ℃ of oven dry postcooling and Borneolum Syntheticum; Mixed then vaseline furnishing pasty state.

10, a kind of as the preparation method of treatment cyclomastopathy and antineoplastic Chinese medicine composition as described in each in the claim 1～4, it is characterized in that the preparation of described external used medicine may further comprise the steps:

Described component is mixed by proportioning except that Borneolum Syntheticum, drop into pulverizer and be ground into fine powder, after sieving, puts into fine powder the acid and alkali-resistance infusion kettle, at normal temperatures, flooded 15～30 days with ethanol, liquid and medicinal residues that dipping is good carry out squeeze and filter, get filtrate after the separation, pulverize Borneolum Syntheticum and add filtrate, stir, mixed then vaseline furnishing pasty state.