CN1216626C - Shenhong capsule with actions of removing blood stasis and obstruction - Google Patents

Abstract

The present invention provides a shenhong capsule having the functions of removing blood stasis and obstruction, which is used for treating cancers. The present invention is prepared by refining and extracting 16 pure Chinese herbal medicines, such as ginseng, safflower, radix trichosanthis, astragalus root, dried longan pulp, corydalis, etc. The present invention is an anticancer medicine which has the characteristics of no toxicity, safety, broad spectrum and effectiveness. The present invention has the efficiency of supplementing qi, activating blood circulation, removing blood stasis, alleviating pain, clearing away heat and toxic materials and softening and resolving hard mass. Clinical researches indicate that the present invention has a certain therapeutical effect on middle-advanced malignant tumors; when the present invention is used together with chemotherapy, malignant tumor focus can be reduced, and some patients can obtain the chance of cutting the focus; the total effective rate reaches 92.3%, and the survival time of most patients is prolonged. The present invention also has the advantages of reducing the toxic and side effect of chemotherapy and improving body immune competence, and the toxic and side effect is light; the present invention can be used for the combined treatment of advanced tumors; when advanced cancer patients take the shenhong capsule, pain can be relieved, life can be prolonged, and life quality can be increased.

Description

A kind of anti-cancer capsule of eliminating stasis and resolving masses

Technical field:

The present invention relates to a kind of anticancer agent made from Chinese herbal medicine, this medicament name is called " joining red eliminating stasis and resolving masses capsule " (original name: peace younger brother recovering capsule).

Background technology:

Talk cancer, people's mood is seemingly turned pale at the mention of the tiger, and " cancer " two words have become dead synonym.It resembles the life that fierce floods and savage beasts have seized ten million people.Up to now, the treatment method for cancer is concluded four kinds: operation, X-ray therapy, chemical method and immunotherapy.This important function for of research the person think, first three methods system machinery, physics and chemical method only can be administered it partly in the angular field of view of naked eyes, Contemporary Physics instrument test, cut off, what kill also is the part, what bring to patient is the misery of treatment, prolongs very few life time.Immunotherapy is intended to improve patient's autoimmune ability, and the person of taking effect only runs into one or two example once in a while.Chinese physician's method roughly is divided into two kinds: A, treating the poisonous disease with poisonous drugs; B, strengthen resistance of human body with tonic Chinese medicine, or blood circulation promoting and blood stasis dispelling, the person of proving effective is very few.This research is through the arduous exploration of many decades, and Preliminary study has its original deep property to Puli Gao Jin " dissipative structure " theoretic comprehension, explanation life dynamic process.

Summary of the invention:

The present invention has assembled multi-disciplinary elite in modern age (the SPPS technology of quantum-mechanical complementary theory, Pauli's exclusion principle, ligand field opinion, crystal field theory and molecular orbital theory, the omnipotent complex catalysis theory of G.Wilkinson, Merrifield and polymerase chain (PCR) reaction ...), scientist and medical scholars develop the good medicine of comparatively ideal treatment cancer finally through the effort of many decades.This medicine refines through science with multiple Chinese herbal medicine and forms, and its main pharmacodynamics material is special many carboxyls hydroxylation organic carrier bonding transition metal complex (latter is commonly called as ' killer ').Through digestive tract, enter human tissue cell by blood, lymph circulation; optionally the normal and unusual cancerous tumor cell of identification then with oncogene DNA complexation, cuts the DNA of abnormal activation; make cancerous cell lose the function of hereditary compound reorganization, thereby reach the purpose of treatment cancer.

Principle of the present invention is:

Stasis of blood disease means that blood vessels operations is not smooth, even stagnates cohesion, or the blood circulating out of vessels various clinical diseases that amass in body to be produced.Chinese medicine is thought blood among passages through which vital energy circulates, should be popular more than, and ring week if blood is popular to be obstructed, disease will take place endlessly.Stasis of blood disease forms, and reason is many, hinders as feelings will, and depression and stagnation of QI blood is capable to be obstructed; Prolonged illness is weakened body resistance, the hemodynamic deficiency; And being invaded by exogenous pathogen, food and drink does not save, and the improper grade of stopping blooding all can influence the normal function of QI and blood or blood vessels, and hematogenous blockage, stasis of blood plug do not loose, and produce stasis of blood disease.The clinical manifestation of stasis of blood disease has varied, its pain is the outstanding symptom of stasis of blood disease, stagnation of QI and blood may bring about pain, its localized pain, often with blood stasis location performance fixed position, as chest pain, headache, stomachache etc., it is livid purple to be also shown in onyx, subcutaneous purpura, squamous and dry skin, the human body numbness, cyanotic lips, dark tongue quality or ecchymosis hesitant pulse etc. is arranged.Stasis of blood disease with the passing of time, tool gas is how empty, or the positive deficiency of vital energy and suffer from stasis of blood disease, can doublely see spiritlessness and weakness, deficiency of QI with disinclination to talk, appetite subtracts greatly, wasting and atrophy of muscle etc.Blood stasis due to qi deficiency disease Therapeutic Principle should be a benefiting QI for activating blood circulation, stasis-dispelling and pain-killing.The present invention has this function, establishes for blood stasis due to qi deficiency disease and cancer belong to above-mentioned disease person.

The present invention is that the weight proportion of selected material component is according to the pure Chinese medicinal preparation of traditional Chinese medical theory and the meticulous development of experience:

60 parts of Radix Ginsengs, 60 parts of the Radixs Astragali, 60 parts of Radix Codonopsis, 50 parts of Fructus Lycii, 50 parts of Radix Angelicae Sinensis, 60 parts of Arillus Longans, 50 parts of the Radix Aucklandiae, 50 parts of the Rhizoma Atractylodis Macrocephalaes, 50 parts on Flos Carthami, 50 parts of Caulis Spatholobis, 250 parts of Radix Trichosanthis, 30 parts of Rhizoma Coptidis, 30 parts of Thallus Laminariae (Thallus Eckloniae)s, 30 parts of Semen Ziziphi Spinosaes, 30 parts of Sargassums, 100 parts of Rhizoma Corydalis (processed with vinegar), Pulvis Talci, starch are an amount of.

Press the monarch principles of formulating prescriptions and analyze prescription compatibility of medicines:

The Radix Ginseng strongly invigorating primordial QI is the QI invigorating key medicine in the side, the Flos Carthami blood circulation promoting and blood stasis dispelling, and inducing menstruation to relieve menalgia is monarch drug altogether.Be aided with the Radix Astragali, Radix Codonopsis QI invigorating, QI invigorating; Radix Angelicae Sinensis, Caulis Spatholobi are invigorated blood circulation, enrich blood; Rhizoma Corydalis, the Radix Aucklandiae are invigorated blood circulation, circulation of qi promoting, pain relieving, are ministerial drug altogether.Strengthen the monarch drug effect.With Fructus Lycii, Arillus Longan, Semen Ziziphi Spinosae nourishing essence-blood, tranquilizing by nourishing the heart; Rhizoma Atractylodis Macrocephalae the spleen strengthening and damp drying; Sargassum, Thallus Laminariae (Thallus Eckloniae) hard masses softening and resolving, diuretic; Rhizoma Coptidis, Radix Trichosanthis heat-clearing and toxic substances removing, detumescence are adjuvant drug altogether.All medicines share, and set upright and get rid of evils, and benefiting QI for activating blood circulation is arranged, stasis-dispelling and pain-killing, heat-clearing and toxic substances removing, hard masses softening and resolving effect.Be used for blood stasis due to qi deficiency disease and cancer and belong to upward disease person.

The technological process of production is referring to accompanying drawing.

This joins red eliminating stasis and resolving masses capsule is non-toxic and safe, wide spectrum and effective anticarcinogen.Have benefiting QI for activating blood circulation, stasis-dispelling and pain-killing, heat-clearing and toxic substances removing, the effect of hard masses softening and resolving.Show that through clinical research joining red eliminating stasis and resolving masses capsule has certain therapeutical effect to advanced malignant tumor, share with chemotherapy, the malignant tumor focus is dwindled, part patient obtains the chance that focus is cut, and total effective rate reaches 92.3%, and prolong the life cycle of most patients.Join red eliminating stasis and resolving masses capsule and also have the minimizing chemical therapy toxic side effect, the advantage of human body immunity improving ability, and toxic and side effects is light.The Comprehensive Treatment that can be used for late tumor.Patient with advanced cancer is taken the red eliminating stasis and resolving masses capsule of ginseng and can be palliated the agonizing sufferings, life-saving and raising life quality.

The pharmacodynamic experiment that the applicant entrusts Zhongshan Medical Univ.'s Experimental Animal Center and medical animal experiment portion to be done also obtains to draw a conclusion:

1, six kinds of cancerous cell such as M～803 all there is the significance inhibitory action.

2, the animal model tumor is had the significance inhibitory action, suppression ratio is greater than 80%.

3, significance prolongs the life-span of tumor model animal.

4, cancerous cell inoculation growth there is the significance preventive effect.

5, humoral immunization and cellular immune function all there is remarkable facilitation.

6, the model of blood dificiency effect of being significantly improved that chemistry and radiation damage method are caused.

7, nervous system there is the effect of significance sedation and analgesia.

Description of drawings:

Below in conjunction with drawings and Examples the whole production process is elaborated.

Fig. 1 is a process chart of the present invention.

The specific embodiment:

1, method for making

1. Radix Ginseng is cleaned with clear water, in oven dry below 50 ℃, beats powder, and it is standby to cross 100 mesh sieves.

2. Radix Trichosanthis, Rhizoma Corydalis clean the back with 80% alcohol extraction twice, reflux 3 hours at every turn, and reflux extracting liquid merges, and reclaim under reduced pressure ethanol does not have vinosity to distillate, and it is standby to get the wine dipper stiff paste.

3. medicinal residues merge with remaining 13 flavor medical materials behind the above-mentioned wine dipper, add water boil and extract 2 times, and each amount of water is 6～10 times of medical material.It is standby also will to collect volatile oil when extracting for the first time.The decocting in water extract filters the back and merges, and when evaporation and concentration is 1.08～1.10 (80 ℃) to relative density, adds Radix Ginseng fine powder, wine dipper stiff paste while hot, mixing, further evaporation and concentration, is poured in the pallet when (80 ℃) to relative density＞1.35, in oven dry below 80 ℃, get dry extract.

4. get above-mentioned dried cream and beat powder, add the Pulvis Talci mixing, and spray adds with a small amount of alcohol-soluble volatile oil simultaneously, after airtight 24 hours, cross 60 mesh sieves according to the equivalent incremental method.Use the hard capsule packing, and then with the capsule glass bottle of packing into, or in other listing packings, get product.

2, working condition

According to 10 batches, the medical material processed result of separate sources, the pulverizing yield of Radix Ginseng is 92.3%, stipulates that by prescription in 1000 capsules, the weight of non-adjuvant content is: 252g, add an amount of Pulvis Talci, starch is adjuvant, should select capsule for use No. 1.

The main chemical compositions of contained each medical material of this product and processing are extracted according to as follows:

Radix Ginseng: the Radix Ginseng for the pharmacopeia regulation mainly contains ginsenoside I-VI, panaxynol, panax acid, volatile oil ... Deng, because comparatively valuable, adopt and make fine powder all the clothes mode of going into is comparatively favourable.

The Radix Astragali: contain water soluble ingredients such as sucrose, phlegmatic temperament, aminoacid, bitter principle, choline, betanin, folic acid, Bears foline, adopt the water boil method to extract.

Radix Codonopsis: contain Saponin, micro-alkaloid, sucrose, glucose, inulin, phlegmatic temperament etc., mostly be water soluble ingredient, adopt the water boil method to extract.

Fructus Lycii: contain carotene, thiamine, riboflavin, Yan acid, ascorbic acid, cupreol etc. mostly are water soluble ingredient, adopt the water boil method to extract.

Radix Angelicae Sinensis: contain volatile oil, volume sucrose, vitamin B1ies etc. take steam distillation to collect volatile oil, the method that water boil extracts.

Arillus Longan: contain water soluble ingredient and reach 79.77%, be mainly: glucose, sucrose, acids, adenine and choline etc.Can adopt the water boil method to extract.

The Radix Aucklandiae: contain volatile oil, stigmasterol, betulin, resin and saussurine, adopt steam distillation to collect volatile oil, water boil extraction method.

The Rhizoma Atractylodis Macrocephalae: contain volatile oil, vitamin A etc., the method that adopts steam distillation to collect volatile oil is extracted.

Flos Carthami: contain insoluble compositions such as Carthamus yellow and carthamin, adopt the water boil extraction method.

Caulis Spatholobi: contain Caulis Spatholobi acid etc., can adopt the water boil method to extract.

Radix Trichosanthis: contain volume starch and Saponin, and contain trichosanthin, several amino acids composition, the method that can adopt reflow of alcohol and water boil to extract.

Rhizoma Coptidis: contain most alkaloids that can be water-soluble such as berberine, coptisine, 13-methyl-.psi.-coptisine., Chinese bush cherry leaf coculine, paAlmatine, can adopt the water boil method to extract.

Rhizoma Corydalis (vinegar system): contain purple alkali, tetrahydropalmatine more than 10 kind of alkaloids such as (Rhizoma Corydalis second elements), salt can be by water, ethanol dissolving, so the method for decocting in water after employing 80% reflow of alcohol can be extracted its most active ingredients after the vinegar system.

Semen Ziziphi Spinosae: contain Semen Ziziphi Spinosae saponin, volume vitamin C etc., can adopt the water boil method to extract.

Sargassum: contain that algin acid, thick amount are white, mannitol, potassium, iodine, trace element etc.

Thallus Laminariae (Thallus Eckloniae): contain algin acid, laminaran, mannitol, inorganic salt, trace element, vitamin C, carotene, riboflavin, aminoacid, protein etc.Can adopt the water boil method to extract.

This technology is extracted the dried cream make, has stronger to draw moistly, for making things convenient for capsule subpackage and regulating divided dose, adds an amount of Pulvis Talci, starch.Many batches of medicinal material extract experimental results, 1000 capsules contents select for use a capsule subpackage comparatively suitable between 300～350g.

The actual recovery of this technology finished product is 96.1% of a theoretical yield.

3, embodiment:

Example 1:

A, take by weighing raw material: Radix Ginseng 1800g, Radix Astragali 1800g, Radix Codonopsis 1800g, Fructus Lycii 1500g, Radix Angelicae Sinensis 1500g, Arillus Longan 1800g, Radix Aucklandiae 1500g, Rhizoma Atractylodis Macrocephalae 1500g, Flos Carthami 1500g, Caulis Spatholobi 1500g, Radix Trichosanthis 7500g, Rhizoma Coptidis 900g, Rhizoma Corydalis (vinegar system) 3000g, Semen Ziziphi Spinosae 900g, Sargassum 900g, Thallus Laminariae (Thallus Eckloniae) 900g, Pulvis Talci is an amount of.

B, method for making:

1. Radix Ginseng is cleaned with clear water, in oven dry below 50 ℃, is ground into fine powder, and it is standby to cross 100 mesh sieves.

2. Rhizoma Corydalis, Radix Trichosanthis add 36.75 liters of reflux, extract, of 80% ethanol for the first time, extracted 3 hours, get alcohol extract (1), medicinal residues add 21 liters of reflux, extract, of 80% ethanol for the second time again, extract 3 hours, get alcohol extract (2), merge (1), (2) extracting solution, filter, decompression filtrate recycling ethanol is not to there being the alcohol flavor, and it is standby to be concentrated into relative density 1.09.

3. 13 flavor medicines such as the Radix Astragali of the Rhizoma Corydalis of alcohol extraction, Radix Trichosanthis medicinal residues and remainder, Radix Codonopsis merge, and add water boil to extract 2 times, and each 2 hours, amount of water was 160kg at every turn.Collecting decoction filters, and it is 1.09 that filtrate is concentrated into relative density, adds Radix Ginseng fine powder, alcohol extraction condensed cream while hot, and mixing is concentrated into relative density and is 1.37 thick paste, and 60 ℃ of oven dry promptly get dry extract.

4. dried cream powder is broken into fine powder, adds Pulvis Talci 1440g, starch 360g mixing.Spray adds with the dissolved volatile oil of small amount of ethanol, after airtight 24 hours, crosses 60 mesh sieves, uses the hard capsule packing.

5. output is 29108, and yield is 97.0%.

Example 2:

A, take by weighing raw material: Radix Ginseng 1800g, Radix Astragali 1800g, Radix Codonopsis 1800g, Fructus Lycii 1500g, Radix Angelicae Sinensis 1500g, Arillus Longan 1800g, Radix Aucklandiae 1500g, Rhizoma Atractylodis Macrocephalae 1500g, Flos Carthami 1500g, Caulis Spatholobi 1500g, Radix Trichosanthis 7500g, Rhizoma Coptidis 900g, court of a feudal ruler Rhizoma Corydalis (vinegar system) 3000g, Semen Ziziphi Spinosae 900g, Sargassum 900g, Thallus Laminariae (Thallus Eckloniae) 900g, Pulvis Talci is an amount of.

B, method for making:

1. Radix Ginseng is cleaned with clear water, in oven dry below 50 ℃, is ground into fine powder, and it is standby to cross 100 mesh sieves.

2. Rhizoma Corydalis, Radix Trichosanthis add 36.75 liters of reflux, extract, of 80% ethanol for the first time, extracted 3 hours, get alcohol extract (1), medicinal residues add 21 liters of reflux, extract, of 80% ethanol for the second time again, extract 3 hours, get alcohol extract (2), merge (1), (2) extracting solution, filter, decompression filtrate recycling ethanol is not to there being the alcohol flavor, and it is standby to be concentrated into relative density 1.10.

3. 13 flavor medicines such as the Radix Astragali of the Rhizoma Corydalis of alcohol extraction, Radix Trichosanthis medicinal residues and remainder, Radix Codonopsis merge, and add water boil to extract 2 times, and each 2 hours, amount of water was 160kg at every turn.Collecting decoction filters, and it is 1.10 that filtrate is concentrated into relative density, adds Radix Ginseng fine powder, alcohol extraction condensed cream while hot, and mixing is concentrated into relative density and is 1.38 thick paste, and 60 ℃ of oven dry promptly get dry extract.

4. dried cream powder is broken into fine powder, adds Pulvis Talci 1440g, starch 360g mixing.Spray adds with the dissolved volatile oil of small amount of ethanol, after airtight 24 hours, crosses 60 mesh sieves, uses the hard capsule packing.

5. output is 29040, and yield is 96.8%.

This joins red eliminating stasis and resolving masses capsule is to be made through special technology by the above-mentioned raw materials prescription.Joining red eliminating stasis and resolving masses capsule is special many carboxyls hydroxylation organic carrier bonding transition metal complex, it is through digestive tract, enter human tissue cell by blood, lymph circulation, carry out ligand exchange reaction with oncogene DNA, this ultramicron transition metal complex and oncogene complexation, chelating, oncogene DNA withers away, and loses the function to the compound reorganization of cancerous cell, thereby reaches the purpose of treatment cancer.Its action principle mainly is to produce the dissipation phenomenon after red eliminating stasis and resolving masses capsule selection of ginseng and the oncogene complexation, make the consumption of cancerous cell gene and degeneration, inactivation, necrosis, its process is exothermic reaction, can make the focus of all constitutionales or transitivity malignant tumor and even disappearance and effects a radical cure; Late period and the cachexia cancer patient who extensively shifts obviously delay growth of tumor and transfer, and can unite to use with other therapies has synergism.Zoopery also proves the effect of bringing out cancer that prevents carcinogen and the effect that suppresses the transplantation tumor growth.In addition, also have effects such as pain relieving significantly, raising immunologic function.

Claims (1)

1, a kind of anti-cancer capsule of eliminating stasis and resolving masses is characterized in that it being that raw material by following weight parts is made:

60 parts of Radix Ginsengs, 60 parts of the Radixs Astragali, 60 parts of Radix Codonopsis, 50 parts of Fructus Lycii, 50 parts of Radix Angelicae Sinensis, 60 parts of Arillus Longans, 50 parts of the Radix Aucklandiae, 50 parts of the Rhizoma Atractylodis Macrocephalaes, 50 parts on Flos Carthami, 50 parts of Caulis Spatholobis, 250 parts of Radix Trichosanthis, 30 parts of Rhizoma Coptidis, 30 parts of Thallus Laminariae (Thallus Eckloniae)s, 30 parts of Semen Ziziphi Spinosaes, 30 parts of Sargassums, 100 parts of Rhizoma Corydalis (processed with vinegar), Pulvis Talci, starch are an amount of.