CN1876128A - A medicine for treating metrorrhagia and preparation process thereof - Google Patents
A medicine for treating metrorrhagia and preparation process thereof Download PDFInfo
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- CN1876128A CN1876128A CN 200510042762 CN200510042762A CN1876128A CN 1876128 A CN1876128 A CN 1876128A CN 200510042762 CN200510042762 CN 200510042762 CN 200510042762 A CN200510042762 A CN 200510042762A CN 1876128 A CN1876128 A CN 1876128A
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Abstract
The invention relates to a medicament for treating polymenorrhea and process for preparation, wherein the medicament is prepared from astragalus root, Chinese angelica root, dipsacus root, pilose asiabell root, motherwort, red sage root, herba patriniae and nutgrass flatsedge rhizome through ethanol extracting, water extracting alcohol settling, and water vapor distilling.
Description
One, technical field
The present invention relates to a kind of haemostatic medicament and preparation technology thereof, specifically a kind of medicine and preparation technology thereof who treats metrorrhagia belongs to field of pharmaceutical technology.
Two, background technology
Women's postpartum lochiorrhea is because impairment caused by overstrain passages through which vital energy circulates when producing causes QI-blood circulation not normal.And cause a class disease that more than three weeks of puerperal, still has colporrhagia.Women's metrorrhagia in puerperal, lochia are one of department of obstetrics and gynecology common clinical.Calculate with China birth rate, have every year 40000000 women to experience birth process approximately, situation such as interruption of pregnancy such as artificial abortion, induced labor in addition, patient group also can increase greatly.In childbirth, artificial abortion, the induced labor process because lose blood, impairment of YIN, consumption gas, and the cloudy blood consumption of puerpera is hindered, the vigour loss, QI and blood is all empty, causes QI failing to control blood, the debility of CHONG and REN meridians, lochia.If untimely treatment or delay are with the passing of time, the empty the moon of the impairment of YIN of then can losing blood and hyperamization exhausts, and can cause secondary anemia, has a strong impact on the healthy of puerpera.
China mainly treats with Chinese medicine and two kinds of methods of Western medicine women's metrorrhagia in puerperal, lochia.Though Western medicine can reach the effect of getting instant result when this disease of treatment, toxic and side effects is bigger when western medicine women metrorrhagia in puerperal, lochia disease, outbreak repeatedly easily, and can not fundamentally thoroughly cure this disease.China is a Chinese medicine big country, treatment by Chinese herbs women metrorrhagia in puerperal, lochia disease have a long history, Chinese medicine not only can reach rapid hemostatic effect, the more important thing is and to carry out double recuperation to human body, thereby reach equilibrium between yin and yang, QI and blood is normally moved, reached the hemostatic purpose.
At present, though treatment by Chinese herbs women metrorrhagia in puerperal, lochia effect are all well and good, these Chinese medicinal components are very many, more than nearly tens flavors that have, increased patient's financial burden in this mercilessness.In the past, the medical science detection means falls behind, and some medicine can't find out that to the toxic and side effects of human body along with the continuous development of science and technology, these toxic and side effects are presented in face of the people clearly.
Three, summary of the invention
Women's postpartum lochiorrhea is because of deficiency of qi and blood, and due to the debility of CHONG and REN meridians, take good care of oneself characteristic and whole sight of Chinese medicine have remarkable advantages in clinical treatment.Factors such as lochia is for to be deteriorated bloodization, and puerperal asthenia is defended a little less than the exopathogen power in addition, and puerperium is unclean are invaded in the easy evil poison and send out to be infected, so Yi Zuo is with the product of heat-clearing and toxic substances removing, when based on the benefiting QI and nourishing blood blood stasis dispelling.
Purpose of the present invention be exactly for solve present treatment women metrorrhagia in puerperal, the employed Chinese medicine component of lochia is many, complicated process of preparation, extract drugs is insufficient, and the Chinese crude drug waste is big, thereby a kind of medicine and preparation technology thereof who treats metrorrhagia is provided.
The present invention can realize by following scheme in order to achieve the above object:
A kind of medicine for the treatment of metrorrhagia, it is the medicament of being made according to weight proportion by following raw materials according:
The Radix Astragali 220～245 Radix Angelicae Sinensis 190～210 Radix Dipsacis 220～245
Radix Codonopsis 190～210 Herba Leonuris 190～210 Radix Salviae Miltiorrhizaes 110～124
Herba Patriniae 190～210 Rhizoma Cyperis 110～124.
A kind of medicine for the treatment of metrorrhagia, the medicament that it is made according to weight proportion by following raw materials according:
The Radix Astragali 236 Radix Angelicae Sinensis 198 Radix Dipsacis 236
Radix Codonopsis 198 Herba Leonuris 198 Radix Salviae Miltiorrhizaes 118
Herba Patriniae 198 Rhizoma Cyperis 118.
The medicine of treatment metrorrhagia, it is that the dosage form of the medicament made by above-mentioned raw materials is a granule shape.
The preparation technology of the medicine of treatment metrorrhagia, it is to be prepared from by following method:
In the above-mentioned raw materials, get Radix Salviae Miltiorrhizae, add 50% ethanol of 8 times of amounts, extract 3 times, each 1 hour, filter, merging filtrate, decompression recycling ethanol is concentrated into relative density and is 1.25 (70～75 ℃) clear paste, and is standby;
Get Radix Angelicae Sinensis, Rhizoma Cyperi is ground into 40～60 order coarse powder, extracts volatile oil with steam distillation, decocting liquid is standby;
Get volatile oil beta-schardinger dextrin-inclusion, inclusion complex is standby;
All the other 5 flavor medical material Radixs Astragali, Radix Dipsaci, Radix Codonopsis, Herba Leonuri, Herba Patriniae decocts with water 3 times, (add Radix Angelicae Sinensis when decocting for the third time, the Rhizoma Cyperi medicinal residues), each 1 hour, merge 3 decoction liquor and Radix Angelicae Sinensis, Rhizoma Cyperi decocting liquid filters, it is 1.19-1.21 (70～75 ℃) that filtrate decompression is concentrated into relative density, put and be chilled to room temperature, add ethanol and make and contain alcohol amount and reach 60%, stir evenly, left standstill 24 hours, reclaim ethanol and be concentrated into the clear paste that relative density is 1.25 (70～75 ℃), qinghuo reagent and above Radix Salviae Miltiorrhizae clear paste merge, and add adjuvant dextrin 500, protein sugar 20, stir, vacuum drying is pulverized, and crosses 100 mesh sieves, add above volatile oil-beta-cyclo dextrin included compound and add dextrin again and complement to 1000, mixing is made granule, drying, packing, sterilization promptly.
The advantage that the present invention had is: the preparation of Chinese crude drug prescription is reasonable, and preparation technology is simple, medicine purification degree height, and the Chinese crude drug consumption is few, and the effective ingredient height can fully effectively utilize drug resource, has vital energy benefiting and the kidney invigorating, the effect of the blood stasis dispelling of nourishing blood.To puerperal metrorrhagia, lochia, deficiency of qi and blood, lusterless complexion, hypogastralgia, shortness of breath and fatigue, soreness of the waist and knees good therapeutical effect is arranged, women patient had opsonic action, can fundamentally thoroughly treat women's metrorrhagia, lochia, no longer recurrence after the healing.
Four, the specific embodiment
The raw material prescription is got according to weight proportion (gram):
The Radix Astragali 236 Radix Angelicae Sinensis 198 Radix Dipsacis 236
Radix Codonopsis 198 Herba Leonuris 198 Radix Salviae Miltiorrhizaes 118
Herba Patriniae 198 Rhizoma Cyperis 118.
The dosage form of the medicament made from above-mentioned prescription is a granule shape.
Production method and step are:
In the above-mentioned raw materials, get Radix Salviae Miltiorrhizae, add 50% ethanol of 8 times of amounts, extract 3 times, each 1 hour, filter, merging filtrate, decompression recycling ethanol is concentrated into relative density and is 1.25 (70～75 ℃) clear paste, and is standby;
Get Radix Angelicae Sinensis, Rhizoma Cyperi is ground into 40～60 order coarse powder, extracts volatile oil with steam distillation, decocting liquid is standby;
Get volatile oil beta-schardinger dextrin-inclusion, inclusion complex is standby;
All the other 5 flavor medical material Radixs Astragali, Radix Dipsaci, Radix Codonopsis, Herba Leonuri, Herba Patriniae decocts with water 3 times, (add Radix Angelicae Sinensis when decocting for the third time, the Rhizoma Cyperi medicinal residues), each 1 hour, merge 3 decoction liquor and Radix Angelicae Sinensis, Rhizoma Cyperi decocting liquid filters, it is 1.19 (70～75 ℃) that filtrate decompression is concentrated into relative density, put and be chilled to room temperature, add ethanol and make and contain alcohol amount and reach 60%, stir evenly, left standstill 24 hours, reclaim ethanol and be concentrated into the clear paste that relative density is 1.25 (70～75 ℃), qinghuo reagent and above Radix Salviae Miltiorrhizae clear paste merge, and add adjuvant dextrin 500g, protein sugar 20g, stir, vacuum drying is pulverized, and crosses 100 mesh sieves, add above volatile oil-beta-cyclo dextrin included compound and add the adjuvant dextrin again and complement to 1000g, mixing is made granule, drying, packing, sterilization promptly.
Form by eight flavor Chinese medicines, have vital energy benefiting and the kidney invigorating, the blood stasis dispelling of nourishing blood.Be used for the treatment of metrorrhagia, postpartum lochiorrhea, lusterless complexion, hypogastralgia, shortness of breath and fatigue, soreness of the waist and knees.
According to the physicochemical property of the contained chemical constituent of each flavour of a drug in the prescription, Radix Salviae Miltiorrhizae is adopted 50% ethanol extraction, taken into account liposoluble constituent-Radix Salviae Miltiorrhizae quinones and water soluble ingredient-phenolic acids; The Radix Astragali, Radix Codonopsis, Radix Dipsaci, Herba Leonuri, Herba Patriniae are adopted decoction and alcohol sedimentation technique; Radix Angelicae Sinensis, Rhizoma Cyperi adopt steam distillation to extract volatile oil, its volatile oil beta-schardinger dextrin-inclusion, decocting liquid precipitate with ethanol, and effective component extraction rate and paste-forming rate reach optimum extraction and process for refining than higher.
Name of product of the present invention is a beneficial palace granule.
Function according to the present invention cures mainly and indication, and it has been carried out relevant pharmacodynamics test:
Extractum of the present invention can shorten mice bleeding time and clotting time by 20,10 and 5g crude drug/Kg gastric infusion, alleviates the microcirculation disturbance that is caused by dextran, and glacial acetic acid induced mice writhing response is had the obvious suppression effect.The present invention can also strengthen the contraction movement of Cavia porcellus in the body uterus.
Acute toxicity test: the present invention does not find toxic reaction to mice one twice-daily gastric infusion 205g crude drug/Kg after the administration, observed 7 days, and 20 mices all survive, well-grown, and maximum tolerated dose is 205g crude drug/Kg.
The present invention to rat by 50,25 and 12.5g crude drug/Kg gastric infusion, once a day, 12 weeks of successive administration, observe the general reaction of medicine, detect indexs such as hematology, blood biochemical and main organs histopathology.The result shows: each dosage is all found the significantly toxic reaction relevant with administration, and safe dose is 25g crude drug/Kg days, 33 times of quite clinical amount.
Claims (4)
1, a kind of medicine for the treatment of metrorrhagia is characterized in that the medicament of being made according to weight proportion by following raw materials according:
The Radix Astragali 220～245 Radix Angelicae Sinensis 190～210 Radix Dipsacis 220～245
Radix Codonopsis 190～210 Herba Leonuris 190～210 Radix Salviae Miltiorrhizaes 110～124
Herba Patriniae 190～210 Rhizoma Cyperis 110～124.
2, a kind of medicine for the treatment of metrorrhagia according to claim 1 is characterized in that the medicament of being made according to weight proportion by following raw materials according:
The Radix Astragali 236 Radix Angelicae Sinensis 198 Radix Dipsacis 236
Radix Codonopsis 198 Herba Leonuris 198 Radix Salviae Miltiorrhizaes 118
Herba Patriniae 198 Rhizoma Cyperis 118.
3, a kind of medicine for the treatment of metrorrhagia according to claim 1 and 2 is characterized in that the dosage form of the medicament made by above-mentioned raw materials is a granule shape.
4, the described a kind of preparation technology who treats the medicine of metrorrhagia of production claim 3 is characterized in that being prepared from by following method:
In the above-mentioned raw materials, get Radix Salviae Miltiorrhizae, add the ethanol of 8 times of amounts 50%, extract 3 times, each 1 hour, filter, merging filtrate, decompression recycling ethanol is concentrated into relative density and is 1.25 (70～75 ℃) clear paste, and is standby;
Get Radix Angelicae Sinensis, Rhizoma Cyperi is ground into 40～60 order coarse powder, extracts volatile oil with steam distillation, decocting liquid is standby;
Get volatile oil beta-schardinger dextrin-inclusion, inclusion complex is standby;
All the other 5 flavor medical material Radixs Astragali, Radix Dipsaci, Radix Codonopsis, Herba Leonuri, Herba Patriniae decocts with water 3 times, (add Radix Angelicae Sinensis when decocting for the third time, the Rhizoma Cyperi medicinal residues), each 1 hour, merge 3 decoction liquor and Radix Angelicae Sinensis, Rhizoma Cyperi decocting liquid filters, it is 1.19-1.21 (70～75 ℃) that filtrate decompression is concentrated into relative density, put and be chilled to room temperature, add ethanol and make and contain alcohol amount and reach 60%, stir evenly, left standstill 24 hours, reclaim ethanol and be concentrated into the clear paste that relative density is 1.25 (70～75 ℃), qinghuo reagent and above Radix Salviae Miltiorrhizae clear paste merge, and add adjuvant dextrin 500, protein sugar 20, stir, vacuum drying is pulverized, and crosses 100 mesh sieves, add above volatile oil-beta-cyclo dextrin included compound and add dextrin to 1000 again, mixing is made granule, drying, packing, sterilization promptly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100427629A CN100475248C (en) | 2005-06-07 | 2005-06-07 | A medicine for treating metrorrhagia and preparation process thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100427629A CN100475248C (en) | 2005-06-07 | 2005-06-07 | A medicine for treating metrorrhagia and preparation process thereof |
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| CN1876128A true CN1876128A (en) | 2006-12-13 |
| CN100475248C CN100475248C (en) | 2009-04-08 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101797335A (en) * | 2010-04-04 | 2010-08-11 | 李公芝 | Chinese medicinal composition for treating functional uterine bleeding |
| CN108283312A (en) * | 2017-12-28 | 2018-07-17 | 湖州品创孵化器有限公司 | A kind of Herba Leonuri granule and its preparation process with health maintenance effect |
-
2005
- 2005-06-07 CN CNB2005100427629A patent/CN100475248C/en active Active
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101797335A (en) * | 2010-04-04 | 2010-08-11 | 李公芝 | Chinese medicinal composition for treating functional uterine bleeding |
| CN101797335B (en) * | 2010-04-04 | 2011-08-10 | 李公芝 | Chinese medicinal composition for treating functional uterine bleeding |
| CN108283312A (en) * | 2017-12-28 | 2018-07-17 | 湖州品创孵化器有限公司 | A kind of Herba Leonuri granule and its preparation process with health maintenance effect |
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| Publication number | Publication date |
|---|---|
| CN100475248C (en) | 2009-04-08 |
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Effective date of registration: 20101105 Address after: 712000 Xianyang City, Shaanxi province Baoquan Road No. 1 Building 6 floor Carey Patentee after: Shaanxi Jianmin Pharmaceutical Co., Ltd. Address before: Xianyang City, Shaanxi Province, 712000 West Road No. 6 Patentee before: Guo Junjing |