CN1281716A - Medicine for curing diabetic peripheral neuropathy - Google Patents
Medicine for curing diabetic peripheral neuropathy Download PDFInfo
- Publication number
- CN1281716A CN1281716A CN 99110870 CN99110870A CN1281716A CN 1281716 A CN1281716 A CN 1281716A CN 99110870 CN99110870 CN 99110870 CN 99110870 A CN99110870 A CN 99110870A CN 1281716 A CN1281716 A CN 1281716A
- Authority
- CN
- China
- Prior art keywords
- radix
- medicine
- peripheral neuropathy
- diabetic peripheral
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention discloses a medicine for curing diabetic peripheral neuropathy, and said medicine can be made into solid dosage form or liquid dosage form by using 11 Chinese medicinal materials of astragalus rood, red peony root, Chinese engelica root, cinnamon twig, achyranthes root, ephedra, smooth greenbrier and others as raw material through the processes of cleaning, preparing, respectively pulverizing, extracting, filtering and concentrating, etc.. Said invention is unique in prescription and obvious in therapeutic effect.
Description
The present invention relates to a kind of medicine for the treatment of diabetic peripheral neuropathy, a kind of specifically is the Chinese patent medicine of feedstock production with the Chinese herbal medicine.
Diabetes are common frdquently encountered diseases of serious harm human health, diabetics surpasses 100,000,000 people in the world at present, and China surpasses 20,000,000, and the trend that increases is year by year arranged, case fatality rate is only second to malignant tumor and cardiovascular diseases, is the third-largest disease that jeopardizes the human life.
Diabetes do not heal all the life, complication extensively and serious, because insulin lacks relatively or definitely in the blood flow, cause sugar, fat, protein metabolism disorder, cause the rising of hyperglycemia, hyperlipidemia and blood viscosity, especially peripheral neuropathy appears in middle and advanced stage, extremity sensory disturbance, numbness, cool, pain are brought very big misery to the patient.As untimely treatment, " diabetic foot " can take place, entail dangers to life when serious.
At present, domestic to primary disease treatment use:
1, in the Western medicine VB is arranged
1, VB
2, trophism medicines such as inositol sheet, but poor effect;
2, still there is not this type of sick Chinese medicine of treatment in the national drug standards at present.
The object of the present invention is to provide a kind of medicine that diabetic peripheral neuropathy is had special efficacy.
Solution of the present invention is based on motherland's medical science to diabetes and pathogenetic treatment of complication and Therapeutic Principle, and in conjunction with the detecting instrument and the method for doctor trained in Western medicine science, from motherland's medical treasure-house, filter out natural plant, skimming the cream off milk by theory of Chinese medical science combines.
The present invention forms (consumption is a weight portion) by following component:
The Radix Astragali 6～100 Herba Asaris 3～50 Radix Salviae Miltiorrhizaes 3～50
Ramulus Cinnamomi 3～50 Rhizoma Smilacis Glabraes 3～40 Radix Angelicae Sinensis 1～30
Rhizoma Chuanxiong 3～30 Herba Ephedraes 1～20 Radix Aconiti Lateralis Preparata 3～40
Radix Paeoniae Rubra 1～25 Radix Achyranthis Bidentatae 3～40
Pharmaceutical formulation optimum ratio of the present invention (consumption is a weight portion)
The Radix Astragali 10～40 Herba Asaris 5～20 Radix Salviae Miltiorrhizaes 5～20
Ramulus Cinnamomi 5～20 Rhizoma Smilacis Glabraes 5～15 Radix Angelicae Sinensis 4～15
Rhizoma Chuanxiong 5～15 Herba Ephedraes 5～10 Radix Aconiti Lateralis Preparatas 5～15
Radix Paeoniae Rubra 3～10 Radix Achyranthis Bidentataes 5～15
Above-mentioned each component is made medicine production method of the present invention is: raw material is pulverized respectively or is extracted after cleaning, concocting, and extraction unit is divided through after filtering, concentrating, and according to the requirement that will prepare dosage form, medicated powder is mixed and made into again.
Clinical drug of the present invention uses the result to show that following advantage is arranged:
1, to select natural plant for use be raw material in the present invention, and each prescription meets Traditional Chinese medical theory, is made up of pure drug matching, and is nontoxic to human body.
2, the present invention is directed to diabetic peripheral neuropathy and develop, to the extremity sensory disturbance numbness of diabetes, send out cold, pain etc. special efficacy is arranged.
For showing the therapeutic effect of this medicine to diabetic autonomic neuropathy, the present invention has selected 790 routine patients to carry out clinical observation, wherein:
Women 220 examples of treatment group 560 example men, 340 examples
Women 85 examples of matched group 230 example men, 145 examples
Therapeutic Method: the treatment group is taken the medicine watered pill 9 grams of the present invention, every day 1-2 time, 30 minutes after meal warm water delivery services on the basis of blood sugar control.
Matched group: vitamin B
120 milligram of 3/ horse is oral.
Vitamin B
12500 microgram intramuscular injection, the next day once.
Be 3 months the course of treatment.Therapeutic outcome treatment group matched group is cured two groups of contrasts of routine produce effects 170 examples of 130 examples 0 20 examples invalid 10 examples, 80 examples of effective 250 examples 130 examples to be had and obviously looks into different P＜0.05
Wherein: cure: symptom and sign disappear, and electromyogram checks that conduction velocity is normal.
Produce effects: extremity sensory disturbance numbness, cool, the most of disappearance of pain, limb end has feeling of numbness slightly, and the electromyogram conduction velocity significantly improves;
Effectively: extremity sensory disturbance, fiber crops, painful, cold obviously alleviate, and tendon reflex recovers to some extent, and the electromyogram conduction velocity makes moderate progress;
Invalid: symptom, sign, electromyogram do not have improvement.
Embodiment 1:
Raw materials used weight proportion is (a unit: kilogram): the Radix Astragali 6 Herba Asaris 5 Radix Salviae Miltiorrhizaes 5 Ramulus Cinnamomi 5 Rhizoma Smilacis Glabraes 4 Radix Angelicae Sinensis 2 Rhizoma Chuanxiongs 4 Herba Ephedraes 2 Radix Aconiti Lateralis Preparatas 3 Radix Paeoniae Rubra 2 Radix Achyranthis Bidentataes 5
1, raw material is after cleaning, concocting, by the prescription batching;
2, the confected materials decocting boils twice, and 2 hours for the first time, 1.5 hours for the second time, extracting solution is filtered, after removing impurity, high speed centrifugation (or ultrafiltration) suitably concentrates again;
3, with above-mentioned medicinal liquid in the dosing of prescription ratio (adding distil water or deionized water);
4,, and went out in 20～30 minutes and promptly get oral liquid through flowing 100 ℃ of steams with the liquid medicine filling for preparing.
Embodiment 2:
Raw materials used weight proportion is (a unit: kilogram): the Radix Astragali 80 Herba Asaris 45 Radix Salviae Miltiorrhizaes 20 Ramulus Cinnamomi 40 Rhizoma Smilacis Glabraes 10 Radix Angelicae Sinensis 20 Rhizoma Chuanxiongs 25 Herba Ephedraes 20 Radix Aconiti Lateralis Preparatas 40 Radix Paeoniae Rubra 25 Radix Achyranthis Bidentataes 8
Compound method is as follows:
1, raw material, is prepared burden by prescription after the process of preparing Chinese medicine through cleaning;
2, according to raw material ingredient character, with Herba Asari, Ramulus Cinnamomi. Radix Angelicae Sinensis, Rhizoma Chuanxiong extract volatile oil, and 50～70 ℃ of extracting solution are concentrated and oven dry, and volatile oil is through β-CD parcel;
3, the Radix Astragali, Radix Achyranthis Bidentatae, Radix Salviae Miltiorrhizae, last Poria, Radix Paeoniae Rubra, Herba Ephedrae, Radix Aconiti Lateralis Preparata are decocted three times, filter, concentrate, be dried to medicated powder.
4, the volatile oil behind the parcel combines with exsiccant medicated powder and adds attached material, and drying makes granule.
Claims (4)
1, a kind of medicine for the treatment of diabetic peripheral neuropathy is characterized in that: it is the medicament of being made by the following weight proportion raw material:
The Radix Astragali 6～100 Herba Asaris 3～50 Radix Salviae Miltiorrhizaes 3～50
Ramulus Cinnamomi 3～50 Rhizoma Smilacis Glabraes 3～40 Radix Angelicae Sinensis 1～30
Rhizoma Chuanxiong 3～30 Herba Ephedraes 1～20 Radix Aconiti Lateralis Preparata 3～40
Radix Paeoniae Rubra 1～25 Radix Achyranthis Bidentatae 3～40
2, a kind of medicine for the treatment of diabetic peripheral neuropathy according to claim 1, it is characterized in that: it is the medicament of being made by the following weight proportion raw material:
The Radix Astragali 10～40 Herba Asaris 5～20 Radix Salviae Miltiorrhizaes 5～20
Ramulus Cinnamomi 5～20 Rhizoma Smilacis Glabraes 5～15 Radix Angelicae Sinensis 4～15
Rhizoma Chuanxiong 5～15 Herba Ephedraes 5～10 Radix Aconiti Lateralis Preparatas 5～15
Radix Paeoniae Rubra 3～10 Radix Achyranthis Bidentataes 5～15
3, according to claim 1,2 described a kind of medicines for the treatment of diabetic peripheral neuropathy, it is characterized in that: said medicament is a said dosage form on any pharmaceutics.
4, a kind of medicine for the treatment of diabetic peripheral neuropathy according to claim 3, it is characterized in that: said medicament is an oral liquid.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB991108701A CN1151800C (en) | 1999-07-23 | 1999-07-23 | Medicine for curing diabetic peripheral neuropathy |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB991108701A CN1151800C (en) | 1999-07-23 | 1999-07-23 | Medicine for curing diabetic peripheral neuropathy |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1281716A true CN1281716A (en) | 2001-01-31 |
| CN1151800C CN1151800C (en) | 2004-06-02 |
Family
ID=5274756
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB991108701A Expired - Lifetime CN1151800C (en) | 1999-07-23 | 1999-07-23 | Medicine for curing diabetic peripheral neuropathy |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1151800C (en) |
Cited By (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001095920A1 (en) * | 2000-06-16 | 2001-12-20 | Basic, Robert | Composition comprising clinoptolite, plant extracts and vitamin b complex for diabetic neuropathy |
| WO2003013563A3 (en) * | 2001-07-06 | 2003-04-10 | Robert Basic | Mineral-protein preparations (mpp) and neuropathies in diabetes |
| CN100363024C (en) * | 2004-05-18 | 2008-01-23 | 河北省中医药研究院高血压糖尿病研究所 | Chinese traditional medicine named numb pain resolvent for treating diabetes peripheral nervous lesion |
| CN102380049A (en) * | 2011-10-25 | 2012-03-21 | 盛芳 | Ningpo yam rhizome, pangolin scales, Chinese starjasmine stem, epimedium herb, East Asian tree fern rhizome and stiff silkworm decoction for treating diabetic peripheral neuropathy |
| CN102512518A (en) * | 2012-01-05 | 2012-06-27 | 首都医科大学 | Chinese medicinal extract for treating diabetic peripheral neuropathy and preparation method thereof |
| CN101361821B (en) * | 2008-10-10 | 2012-11-14 | 北京中医药大学 | Medicine combination for treating diabetic peripheral neuropathy and preparation method thereof |
| CN103735643A (en) * | 2014-01-20 | 2014-04-23 | 刘华珍 | Traditional Chinese medicine composition for treating diabetic peripheral neuropathy |
| CN104147404A (en) * | 2014-07-18 | 2014-11-19 | 南阳市宛城区第一人民医院 | Traditional Chinese medicine for treating diabetic peripheral neuropathy |
| CN104547420A (en) * | 2014-12-30 | 2015-04-29 | 陈满锦 | Novel application of traditional Chinese medicine composition |
| CN106232114A (en) * | 2014-04-22 | 2016-12-14 | 味之素株式会社 | The prevention of peripheral neuropathy or improvement compositions |
| CN108524832A (en) * | 2018-05-28 | 2018-09-14 | 河北中唐医药有限公司 | A kind of Chinese medicine composition and preparation method thereof for treating diabete peripheral herve pathology |
| CN108721539A (en) * | 2018-07-16 | 2018-11-02 | 石家庄以岭药业股份有限公司 | The preparation method of Chinese medicine composition and its preparation for treating neurogenic disease |
| CN110755501A (en) * | 2019-11-29 | 2020-02-07 | 河南省中医药研究院 | Traditional Chinese medicine composition for treating diabetic peripheral neuropathy |
| CN112121130A (en) * | 2019-10-31 | 2020-12-25 | 福建农林大学 | Traditional Chinese medicine composition for treating/preventing type II diabetes and application thereof |
| CN112220905A (en) * | 2020-11-13 | 2021-01-15 | 广东省中医院（广州中医药大学第二附属医院、广州中医药大学第二临床医学院、广东省中医药科学院） | Traditional Chinese medicine preparation for treating painful neuropathy caused by diabetes |
| CN113813330A (en) * | 2021-10-03 | 2021-12-21 | 王钢柱 | Industrial preparation method of traditional Chinese medicine composition for preventing and treating diabetic peripheral neuropathy and product thereof |
| CN116898941A (en) * | 2023-07-21 | 2023-10-20 | 首都医科大学附属北京中医医院 | Traditional Chinese medicine composition and application thereof, traditional Chinese medicine preparation and preparation method and application thereof |
| CN116898941B (en) * | 2023-07-21 | 2024-04-30 | 首都医科大学附属北京中医医院 | Traditional Chinese medicine composition and application thereof, traditional Chinese medicine preparation and preparation method and application thereof |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100493533C (en) * | 2005-12-26 | 2009-06-03 | 昆明市中医医院 | Medicine for treating diabetes peripheral neuropathy |
-
1999
- 1999-07-23 CN CNB991108701A patent/CN1151800C/en not_active Expired - Lifetime
Cited By (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001095920A1 (en) * | 2000-06-16 | 2001-12-20 | Basic, Robert | Composition comprising clinoptolite, plant extracts and vitamin b complex for diabetic neuropathy |
| WO2003013563A3 (en) * | 2001-07-06 | 2003-04-10 | Robert Basic | Mineral-protein preparations (mpp) and neuropathies in diabetes |
| CN100363024C (en) * | 2004-05-18 | 2008-01-23 | 河北省中医药研究院高血压糖尿病研究所 | Chinese traditional medicine named numb pain resolvent for treating diabetes peripheral nervous lesion |
| CN101361821B (en) * | 2008-10-10 | 2012-11-14 | 北京中医药大学 | Medicine combination for treating diabetic peripheral neuropathy and preparation method thereof |
| CN102380049B (en) * | 2011-10-25 | 2013-04-24 | 盛芳 | Decoction for treating diabetic peripheral neuropathy |
| CN102380049A (en) * | 2011-10-25 | 2012-03-21 | 盛芳 | Ningpo yam rhizome, pangolin scales, Chinese starjasmine stem, epimedium herb, East Asian tree fern rhizome and stiff silkworm decoction for treating diabetic peripheral neuropathy |
| CN102512518A (en) * | 2012-01-05 | 2012-06-27 | 首都医科大学 | Chinese medicinal extract for treating diabetic peripheral neuropathy and preparation method thereof |
| CN102512518B (en) * | 2012-01-05 | 2013-12-04 | 首都医科大学 | Chinese medicinal extract for treating diabetic peripheral neuropathy and preparation method thereof |
| CN103735643A (en) * | 2014-01-20 | 2014-04-23 | 刘华珍 | Traditional Chinese medicine composition for treating diabetic peripheral neuropathy |
| CN103735643B (en) * | 2014-01-20 | 2015-09-02 | 刘华珍 | The Chinese medicine composition for the treatment of diabetic peripheral neuropathy |
| US10653655B2 (en) | 2014-04-22 | 2020-05-19 | Ajinomoto Co., Inc. | Composition for preventing or improving peripheral neuropathy |
| CN106232114A (en) * | 2014-04-22 | 2016-12-14 | 味之素株式会社 | The prevention of peripheral neuropathy or improvement compositions |
| CN106232114B (en) * | 2014-04-22 | 2022-03-18 | 味之素株式会社 | Composition for preventing or improving peripheral neuropathy |
| CN104147404A (en) * | 2014-07-18 | 2014-11-19 | 南阳市宛城区第一人民医院 | Traditional Chinese medicine for treating diabetic peripheral neuropathy |
| CN104547420A (en) * | 2014-12-30 | 2015-04-29 | 陈满锦 | Novel application of traditional Chinese medicine composition |
| CN108524832A (en) * | 2018-05-28 | 2018-09-14 | 河北中唐医药有限公司 | A kind of Chinese medicine composition and preparation method thereof for treating diabete peripheral herve pathology |
| CN108721539A (en) * | 2018-07-16 | 2018-11-02 | 石家庄以岭药业股份有限公司 | The preparation method of Chinese medicine composition and its preparation for treating neurogenic disease |
| CN112121130A (en) * | 2019-10-31 | 2020-12-25 | 福建农林大学 | Traditional Chinese medicine composition for treating/preventing type II diabetes and application thereof |
| CN110755501A (en) * | 2019-11-29 | 2020-02-07 | 河南省中医药研究院 | Traditional Chinese medicine composition for treating diabetic peripheral neuropathy |
| CN112220905A (en) * | 2020-11-13 | 2021-01-15 | 广东省中医院（广州中医药大学第二附属医院、广州中医药大学第二临床医学院、广东省中医药科学院） | Traditional Chinese medicine preparation for treating painful neuropathy caused by diabetes |
| CN113813330A (en) * | 2021-10-03 | 2021-12-21 | 王钢柱 | Industrial preparation method of traditional Chinese medicine composition for preventing and treating diabetic peripheral neuropathy and product thereof |
| CN116898941A (en) * | 2023-07-21 | 2023-10-20 | 首都医科大学附属北京中医医院 | Traditional Chinese medicine composition and application thereof, traditional Chinese medicine preparation and preparation method and application thereof |
| CN116898941B (en) * | 2023-07-21 | 2024-04-30 | 首都医科大学附属北京中医医院 | Traditional Chinese medicine composition and application thereof, traditional Chinese medicine preparation and preparation method and application thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1151800C (en) | 2004-06-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1151800C (en) | Medicine for curing diabetic peripheral neuropathy | |
| CN101940716A (en) | Medicament for treating diabetic nephropathy | |
| CN1839944A (en) | Granular composition for reducing blood fat and process for producing the same | |
| CN102552454A (en) | Traditional Chinese medicine for curing diabetic foot | |
| CN101953918B (en) | Chinese medicinal composition for treating cardiovascular and cerebrovascular diseases | |
| CN1098089C (en) | Medicine for treating hepatitis and liver fibrosis, and method for preparing same | |
| CN1180821C (en) | Medicine for treating cerebral thrombus and its prepn | |
| CN1712060A (en) | Preparation of Chinese medicinal mixture for treating gynecologic menstrual disease | |
| CN1172705C (en) | Patent Chinese medicine for treating diabetes | |
| CN101961448A (en) | Chinese medicament for treating diabetic gout | |
| CN101912537A (en) | Chinese medicinal preparation for treating cerebrovascular neuropathic pain | |
| CN100475248C (en) | A medicine for treating metrorrhagia and preparation process thereof | |
| CN1137919A (en) | Medicine for curing trichomadesis and its preparation method | |
| CN1280835A (en) | Chinese-medicinal capsule for treating hyperlipomia | |
| CN1238028C (en) | Method for preparing capsule of six drugs containing rehmannine | |
| CN102091265A (en) | Traditional Chinese medicine for treating diabetic gout | |
| CN101194958B (en) | Method for preparing decocted ointment for treating headache | |
| CN101530479B (en) | Traditional Chinese medicine for treating diabetes mellitus and muscle atrophy | |
| CN100335111C (en) | Medicine for rheumatism and its preparation | |
| CN1063074C (en) | Chinese herbs injection for treating oncoma (cancer) and preparation method | |
| CN1209125C (en) | Diabetes treating medicine | |
| CN1184993C (en) | Medicines for treating psoriasis | |
| CN1352979A (en) | Chinese medicine for replenishing vital energy and promoting blood circulation | |
| CN1058882C (en) | Oral liquor for treating tumour and disease of liver, and preparation method thereof | |
| CN104383211A (en) | Traditional Chinese medicine clysis fluid for treating chronic renal insufficiency and yang deficiency-induced cold of diabetic nephropathy |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CX01 | Expiry of patent term |
Granted publication date: 20040602 |
|
| CX01 | Expiry of patent term |