CN108524832A - A kind of Chinese medicine composition and preparation method thereof for treating diabete peripheral herve pathology - Google Patents
A kind of Chinese medicine composition and preparation method thereof for treating diabete peripheral herve pathology Download PDFInfo
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Abstract
The present invention relates to a kind of Chinese medicine compositions and preparation method thereof for treating diabete peripheral herve pathology, include the raw material components of following parts by weight：6 18 parts of 6 18 parts of radix aconiti lateralis preparata, 6 21 parts of cassia twig, 12 45 parts of Radix Astragali, 6 18 parts of ginseng, 6 21 parts of Radix Salviae Miltiorrhizae, 6 18 parts of Rhizoma Chuanxiong, 6 18 parts of Radix Angelicae Sinensis, 3 12 parts of radix paeoniae rubra, 6 15 parts of safflower, 6 18 parts of Chinese ephedra, 3 12 parts of asarum, 6 27 parts of smilax, 6 18 parts of rhizoma anemarrhenae and Rhizoma Gastrodiae.Therapeutic effect of the present invention is apparent, and Small side effects are uneasy to recur.
Description
Technical field
The invention belongs to the field of Chinese medicines, specifically a kind of Chinese medicine composition for treating diabete peripheral herve pathology and
Preparation method.
Background technology
Peripheral neuropathy is one of most common chronic complicating diseases of diabetic, according to statistics, diabete peripheral herve
Lesion incidence and diabetic duration length are obviously related, within diabetes illness 1 year its incidence of person 10% hereinafter, the course of disease
10 years person's incidence are 50% or more, and 20 years person's incidence of the course of disease are up to 90% or more, and diverse clinical manifestations, pathological process has
Invisible, gradual feature is one of the main reason for causing non-traumatic amputation.Hair about diabete peripheral herve pathology
The interpretation of the cause, onset and process of an illness is formed with many theories, there is no unified final conclusion, it is now recognized that the generation of diabete peripheral herve pathology and metabolic disorder, micro- blood
Pipe lesion, oxidative stress, neurotrophic factor lack and many factors such as autoimmunity are related.Related diabete peripheral herve
The treatment of lesion, doctor trained in Western medicine, which generally uses, the methods of to be controlled blood glucose, repairs neural, anti-oxidant, improvement microcirculation, using for symptom
A variety of drug combinations, and the use in conjunction of a variety of drugs is with obvious effects in the short time, but is easy recurrence, also increases simultaneously
The probability that adverse drug reaction occurs, final patient have to amputation to save life from damage.
Invention content
To solve the above problems, a kind of therapeutic effect of present invention offer is apparent, and Small side effects, treatment glycosuria uneasy to recur
The Chinese medicine composition and preparation method thereof of sick peripheral neuropathy.
Technical scheme of the present invention：
A kind of Chinese medicine composition for treating diabete peripheral herve pathology includes the raw material components of following parts by weight：It makes attached
6-18 parts sub-, 6-21 parts of cassia twig, 12-45 parts of Radix Astragali, 6-18 parts of ginseng, 6-21 parts of Radix Salviae Miltiorrhizae, 6-18 parts of Rhizoma Chuanxiong, 6-18 parts of Radix Angelicae Sinensis,
3-12 parts of radix paeoniae rubra, 6-15 parts of safflower, 6-18 parts of Chinese ephedra, 3-12 parts of asarum, 6-27 parts of smilax, 6-18 parts of rhizoma anemarrhenae and Rhizoma Gastrodiae 6-18
Part.
Further, include the raw material components of following parts by weight：6-18 parts of radix aconiti lateralis preparata, 6-21 parts of cassia twig, Radix Astragali 12-45
Part, 6-18 parts of ginseng, 6-21 parts of Radix Salviae Miltiorrhizae, 6-18 parts of Rhizoma Chuanxiong, 6-18 parts of Radix Angelicae Sinensis, 3-12 parts of radix paeoniae rubra, 6-15 parts of safflower, Chinese ephedra 6-18
Part, 3-12 parts of asarum, 6-27 parts of smilax, 6-18 parts of rhizoma anemarrhenae, 6-18 parts of Rhizoma Gastrodiae, 6-24 parts of caulis piperis futokadsurae, 6-24 parts of caulis trachelospermi and
6-21 parts of radix cyathulae.
Further, include the raw material components of following parts by weight：10 parts of radix aconiti lateralis preparata, 15 parts of cassia twig, 30 parts of Radix Astragali, ginseng 12
Part, 10 parts of Chinese ephedra, 8 parts of asarum, 16 parts of smilax, is known 15 parts of Radix Salviae Miltiorrhizae, 10 parts of Rhizoma Chuanxiong, 10 parts of Radix Angelicae Sinensis, 8 parts of radix paeoniae rubra, 9 parts of safflower
13 parts of 12 parts female, 10 parts of Rhizoma Gastrodiae, 14 parts of caulis piperis futokadsurae, 15 parts of caulis trachelospermi and radix cyathulae.
A kind of preparation method for treating the Chinese medicine composition of diabete peripheral herve pathology, in weighing by weight
Medicine raw material, 100 DEG C of flowing steam sterilizations 30 minutes are ground into fine powder, and be sieved 100 mesh, by fine powder：Water weight ratio is 1:0.3-
0.8 ratio adds water, stirs evenly, and the water-bindered pill is made, dry, arrange to get.
Further, include the following steps：
Step 1：The Chinese medicine material mixing weighed by weight takes 100 DEG C of 30% Chinese medicine flowing steam sterilization 30 minutes, dry,
It is ground into fine powder, 100 mesh of sieving are spare；
Step 2：Remaining 70% Chinese medicine adds water to cook secondary, and first decocts plus water is 8 times of 70% Chinese medicine weight amounts, decocts 1 hour,
Second decocts 6 times of amounts for adding that water is 70% Chinese medicine weight, decocts 40 minutes, collecting decoction, filtration, 70 DEG C of filtrate is concentrated into relatively close
Degree is 1.15-1.25 g/cm3, and the fine powder after step 1 sieving is added, and the concentration water-bindered pill is made in mixing, dry, arrange to get.
Further, the Chinese medicine material mixing weighed by weight, first decocts add water to be Chinese medicine material total weight 8 times
Amount decocts 1 hour, and second decocts 6 times of amounts for adding that water is Chinese medicine material total weight, decocts 40 minutes, collecting decoction, filtration, filtrate
Ethyl alcohol is added after concentration, it is 50%-80% to make the weight content of ethyl alcohol, and the ethyl alcohol that the ethyl alcohol is 95% carries out alcohol precipitation, takes supernatant
Ethyl alcohol is recycled, and it is 1.20-1.25 g/cm3 clear creams to be concentrated into relative density, the temperature of concentration is 70 DEG C；It is added in clear cream clear
The lactose or dextrin of 2-5 times of cream weight, mixing, granulation, it is dry to get.
Further, the Chinese medicine material mixing weighed by weight, it is that 50-70% alcohol refluxs extract two to add volume fraction
It is secondary, 6-8 times that amount of alcohol is Chinese medicine material total weight is added for the first time and measures, extracts 2 hours, it is Chinese medicine that second, which is added amount of alcohol,
6-8 times of raw material gross weight is measured, and is extracted 2 hours, merges extracting solution, filtration, filtrate recycling ethanol, 70 DEG C are concentrated into relative density
For 1.20-1.25 g/cm3 clear creams；The lactose or dextrin of 2-5 times of clear cream weight are added in clear cream, mixing is pelletized, dry, i.e.,
.
Further, include the following steps：
Step 1：The Chinese medicine material weighed by weight, Radix Astragali, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong are that 50-70% alcohol refluxs carry with volume fraction
It takes three times, adds 6-8 times of Radix Astragali, Radix Salviae Miltiorrhizae and Rhizoma Chuanxiong total weight to measure ethyl alcohol every time, extract 2 hours, filtration, merging filtrate；
Step 2：Asarum, cassia twig, Radix Angelicae Sinensis steam distillation extract volatile oil 4 hours, and volatile oil betadex inclusion is done
It is dry；
Step 3：Asarum, cassia twig, Radix Angelicae Sinensis carry the dregs of a decoction after oil and remaining Chinese medicine material adds water to cook 2-3 times, and every time plus water is thin
Pungent, cassia twig, Radix Angelicae Sinensis put forward 8 times of amounts of the dregs of a decoction and remaining Chinese medicine material total weight after oil, decoct 1 hour, collecting decoction, filtration,
60 DEG C of filtrate is concentrated into the clear cream that relative density is 1.10-1.15 g/cm3, and ethyl alcohol is added to make the volume content 50- of ethyl alcohol in liquid
70%, it places 24 hours, filtration, filtrate merges with above-mentioned alcohol extract, and 60 DEG C of recycling ethyl alcohol are simultaneously concentrated into 1.10-1.15 g/cm3
Clear cream, spray drying or spray-drying process；
Step 4：Dry particl made from step 3 is mixed with inclusion complex made from step 2, and above-mentioned dry particl weight 0.1%- is added
0.8% corrigent Steviosin or aspartame, in addition stating the auxiliary material lactose or dextrin of 1-5 times of dry particl weight, mixing, dry-pressing
Granulation to get.
Further, step 1：The Chinese medicine material weighed by weight, Radix Astragali, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong are 50%- with volume fraction
85% alcohol reflux extracts three times, and every time plus 6-8 times of Radix Astragali, Radix Salviae Miltiorrhizae and Rhizoma Chuanxiong total weight measure ethyl alcohol, extract 2 hours, filter, close
And filtrate；
Step 2：Asarum, cassia twig, Radix Angelicae Sinensis steam distillation 4 hours extract volatile oil；
Step 3：Asarum, cassia twig, Radix Angelicae Sinensis carry the dregs of a decoction after oil and remaining Chinese medicine adds water to cook 2-3 times, every time plus water be asarum,
Cassia twig, Radix Angelicae Sinensis put forward 8 times of amounts of the dregs of a decoction and remaining Chinese medicine weight after oil, decoct 1 hour, collecting decoction, filtration, 60 DEG C of filtrate is dense
It is reduced to the clear cream that relative density is 1.10-1.15, adds ethyl alcohol, ethyl alcohol weight content is made to reach 50%-85%, is placed 24 hours, filtration,
Filtrate merges with above-mentioned alcohol extract, recycles ethyl alcohol, and the clear cream that relative density is 1.10-1.15 g/cm3 is concentrated into 60 DEG C,
The volatile oil of step 2 is added, the corrigent Steviosin or aspartame of above-mentioned clear cream weight 0.05%-0.25% is added, adds purifying
It is 1.10-1.15g/cm that water, which is deployed into relative density,3Oral solution.
Fang Xie：
1, radix aconiti lateralis preparata is the processed goods of the sub- root of the ranunculaceae plant rhizome of Chinese monkshood.Late June to early August excavates, and removes female root, palpus
Root and silt are practised and claim " mud monkshood ", is processed into following specification.（1）Big, the uniform mud monkshood of selection, is cleaned, and immerses courage bar
24 hours in aqueous solution, then add salt, continue to impregnate, daily taking-up, which is shone, dries in the air, and gradually extends to shine and dry in the air the time, until monkshood surface
There is mass crystallization salt grain（Salt efflorescence）, until constitution is hardened, practises and claim " salted aconite root ".（2）Mud monkshood is taken, is cleaned respectively by size,
The a few days in the aqueous solution of courage bar is immersed, boils to the saturating heart, pulls out together with immersion liquid, water drift, the piece of longitudinal sectional Cheng Houyue 0.5cm, then use water
Leaching drift, makes tag dye Umber with toner, takes out, and steams to after there is pasta, gloss, is dried to half-dried, then dries or continues
Drying is practised and claims " black suitable piece ".（3）Mud monkshood of uniform size is selected, is cleaned, a few days in the aqueous solution of courage bar is immersed, together with leaching
Liquid is boiled to the saturating heart, is pulled out, and crust is peelled off, and the piece of longitudinal sectional Cheng Houyue 0.3cm is floated with water logging, is taken out, and is steamed thoroughly, is dried, and it is " white to practise title
Tag ".Main product is in Sichuan, Hubei, Hunan and other places.Belong to drugs for dispelling internal cold.For " the first product of recuperating depleted yang " in Chinese medicine.Its nature and flavor is pungent, sweet,
Big heat；It belongs to the heart, kidney, spleen channel.It is with recuperating depleted yang, the effect of mends fire supporing yang, eliminating cold to stop pain.It collapses for yang depletion, the cold arteries and veins of limb
It is micro-, deficiency of heart-YANG, chest impediment and cardialgia, cold of insufficiency type vomiting and diarrhea, coldness and pain in the epigastrium, decline of kidney-YANG, impotence Gong Leng, cold sensation of the genitalia oedema, deficiency of yang diseases caused by external factors, tremble with fear
Arthritis with fixed pain caused by dampness pain.We's radix aconiti lateralis preparata, as monarch drug in a prescription.
2, cassia twig is the dry twig of canella Chinese cassia tree, and main product is in Guangxi, Guangdong and Yunnan and other places.Spring, summer cut
Lower spray, dries or dries in the shade, and thinly slices or segment is used.Its nature and flavor is pungent, sweet, warm, enters lung, the heart, bladder warp, is that cure mainly interior cold normal
Drugs for dispelling internal cold has complement sun, promoting blood circulation, warming spleen and stomach, sweating expelling pathogenic factors from muscles and skin, warming meridians and promoting circulation of qi, helps yang transforming qi, the work(of eliminating cold to stop pain
Effect；For treating numbness and ache of cold dampness, peripheral coldness, closed dysmenorrhea, abdominal mass caking, the obstruction of qi in the chest, palpitaition, phlegm and retained fluid, difficult urination, chill sense
It emits, coldness and pain in the epigastrium, thromboembolism Amenorrhea, joint pain, phlegm and retained fluid, oedema, palpitaition, all diseases of run quickly globefish.We's cassia twig, as monarch drug in a prescription.
Monkshood, cassia twig share supporing yang cold dispelling in side, and the power of warming meridian is directed to the main pathogenesis of the cold blood stasis of this disease, therefore
For the monarch drug in a prescription of we.
3, Radix Astragali is the dry root of legume astragalus mongolicus or Astragalus membranacus.Main product is in Inner Mongol, Shanxi, Gansu, black
The ground such as Longjiang.Spring, the excavation of two season of autumn, remove fibrous root and root head, dry.Its nature and flavor is sweet, tepor.Return lung, spleen, liver and kidney channel.Have
The effect of tonifying Qi and lifting yang, strengthening exterior and reducing sweat, inducing diuresis for removing edema, shengjin nourishing, move stagnation and palsy, pus draining and toxin expelling, expelling pus and promoting granulation.For the deficiency of vital energy
It is weak, anorexia and loose stool, the sinking of qi of middle-jiao, rush down prolapse of the anus for a long time, uterine bleeding of having blood in stool, exterior deficiency spontaneous perspiration, qi deficiency edema, Heat Diabetes, blood deficiency chlorosis,
Hemiplegia, numbness pain is numb, ulcer is difficult to burst, burst for a long time and does not holds back.Modern medicine study show Radix Astragali have enhancing body's immunity,
Liver protection, diuresis, anti-aging, resisting stress, decompression and wide antibacterial action.Jishengshenqiwan albuminuria can be eliminated, the heart is enhanced
Myotility adjusts blood-sugar content.Radix Astragali can not only coronary artery dilator, improve myocardial blood supply, improve immune function, Er Qieneng
The process of enough delaying cell agings.We's Radix Astragali, as ministerial drug
4, ginseng is the dry root and rhizome of Araliaceae ginseng.Main product is in Northeast China, Korea, South Korea, Japan, Russia sieve
This east.It excavates, is cleaned through drying or drying more than autumn.Its nature and flavor is sweet, slight bitter, tepor.Returns spleen, lung, the heart, kidney channel.Have
It reinforces vital energy, the effect of veins takes off admittedly reinforces the spleen to benefit the lung, shengjin nourishing, tranquilize the mind and promote the intelligence.It to be taken off for physically weak, cold weak pulse of limb, spleen deficiency
Deficiency of food, the deficiency syndrome of the lung are breathed with cough, injury thirst, Heat Diabetes, deficiency of qi and blood, and prolonged illness void is thin, insomnia of palpitating with fear, impotence Gong Leng.Our employment
Ginseng, as ministerial drug.
5, Radix Salviae Miltiorrhizae is the dry root and rhizome of labiate Radix Salviae Miltiorrhizae.National most area is all distributed.Spring, autumn two
Season excavates, and removes silt, dry.Its is bitter in taste, is slightly cold.Converge to heart and liver channels.It is inducing meastruation to relieve menalgia with promoting blood circulation, relieving restlessness that clears away heart-fire,
The effect of cool blood to disappear carbuncle.For chest impediment and cardialgia, gastral cavity abdomen hypochondriac pain, the accumulation of lump in the abdomen lump in the abdomen, hot numbness pain, dysphoria and insomnia, irregular menstruation, dysmenorrhoea
Amenorrhea, sore swell and ache curative.We's Radix Salviae Miltiorrhizae, as ministerial drug.
6, Rhizoma Chuanxiong is the dry rhizome of samphire Rhizoma Chuanxiong.Main product is in Sichuan Guanxian county, in Yunnan, Guizhou, Guangxi etc.
Ground, summer is significantly prominent when the section disk on stem, and is excavated when purplish, removes silt, drying after sun drying, then remove fibrous root.Its property
Taste is acrid in flavour and warm in nature.Return liver, courage, pericardium channel.It is with blood-activating and qi-promoting, the effect of wind-expelling pain-stopping.For chest impediment and cardialgia, chest side of body shouting pain is fallen
Flutter swelling and pain, irregular menstruation, closed dysmenorrhea , Disorder lump in the abdomen is suffered from abdominal pain, headache, arthralgia pain due to rheumatism.We's Rhizoma Chuanxiong, as ministerial drug.
7, Radix Angelicae Sinensis is the dry root of umbelliferae angelica.Main product the southeast of Gansu, it is more with Minxian County yield, it is high-quality,
Secondary is the provinces such as Yunnan, Sichuan, Shaanxi, Hubei, is cultivation.Some domestic provinces and regions also introducing and planting.Autumn end excavates, and removes palpus
Root and silt are bundled into wisp after moisture slightly evaporates, upper canopy, with pyrotechnics slowly smoke-dried beancurd.Its nature and flavor sweet, acrid, warm.Return liver, the heart,
The spleen channel.It is with replenishing and activating blood, menstruction regulating and pain relieving, the effect of relaxing bowel.For blood deficiency chlorosis, dizziness palpitaition, irregular menstruation, warp
Close dysmenorrhoea, asthenia cold abdominalgia, arthralgia pain due to rheumatism, injury from falling down, ulcer sores, dry constipation of intestines.We's Radix Angelicae Sinensis, as ministerial drug.
8, radix paeoniae rubra is the dry root of ranunculaceae plant Chinese herbaceous peony or river radix paeoniae rubra.Chinese herbaceous peony is distributed in northeast, North China, Shaanxi and sweet
It is respectful.There is cultivation in each city and villages and small towns more.River radix paeoniae rubra is distributed in the ground such as Shaanxi, Gansu, Qinghai, Sichuan and Tibet.Careless Chinese herbaceous peony distribution
In the ground such as northeast and Hebei, Shanxi, Shaanxi, Ningxia, Anhui, Zhejiang, Jiangxi, Henan, Hubei, Hunan, Sichuan, Guizhou.Spring, autumn
Two seasons excavated, and removed rhizome, fibrous root and silt, dried.Its is bitter in taste, is slightly cold.Return liver warp.It stops with clearing heat and cooling blood, the scattered stasis of blood
The effect of pain.Enter ying blood for heat, febrile virulent maculae, hematemesis and epistaxis, red eye, swell pain, liver-depressed hypochondrium pain, closed dysmenorrhea, Disorder lump in the abdomen is suffered from abdominal pain,
Injury from falling down, carbuncle swells sore.We's radix paeoniae rubra, as ministerial drug.
9, safflower is the dry flower of feverfew safflower.The ground such as main product Henan, Hunan, Sichuan, Xinjiang, Tibet.Summer flower
It picks, dry in the shade or dries when from yellow to red.It is acrid in flavour and warm in nature.Its nature and flavor converge to heart and liver channels.It is with invigorate blood circulation, the work(of removing blood stasis and analgesics
Effect.For Amenorrhea, dysmenorrhoea, lochia , abdominal mass and lump, chest impediment and cardialgia, stasis of blood, chest side of body twinges, injury from falling down, and sore is swollen
Bitterly.We's safflower, as ministerial drug.
Radix Astragali, ginseng, Radix Angelicae Sinensis blood-enrich, rising Yang row are stagnant in side；Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, radix paeoniae rubra, safflower blood-activating and qi-promoting dissipate the stasis of blood
Analgesic.Not only monarch drug in a prescription warming meridian had been assisted, but also promoting blood circulation and removing blood stasis, and to help the elimination of cold blood stasis, therefore had been ministerial drug altogether.
10, Chinese ephedra is the drying herbaceous stem stem of Ephedraceae plant ephedra sinica, epheday intermedia or ephedra equisetina.Main product is in originating in the Liao Dynasty
Rather, the provinces and regions such as Jilin, the Inner Mongol, Hebei, Shanxi, the Henan northwestward and Shaanxi.Mongolia is also distributed.Autumn taps the grass of green
Matter stem, is dried.Its nature and flavor is pungent, slight bitter, temperature.Return lung, bladder warp.It freeings lung and relieving asthma with sweating cold dispelling, the work(of inducing diuresis for removing edema
Effect.It is uncomfortable in chest to breath with cough for anemofrigid cold, geomantic omen edema.Herba ephedrae moistens the lung and relieve the cough.It is chiefly used in exterior syndrome to have solved, asthma and cough.We
With Chinese ephedra, as adjutant,.
11, asarum is the dry root and rhizome of aristolochiaceae plant Herba Asari, Seoul asarum or asarum sieboldii.The first two kind is practised
Claim " HERBA ASARI from Liaoning of China ".Herba Asari main product is in northeast, and Seoul asarum main product is in Jilin Province, Liaoning Province, and asarum sieboldii main product is in Shaanxi Province, four
Chuan Sheng, Hubei Province；Also it produces on the ground such as Anhui Province, Jiangxi Province, Zhejiang Province.Its nature and flavor is acrid in flavour and warm in nature.The thoughts of returning home, lung, kidney channel.Summer fructescence
Or early autumn excavation, cleared aerial part and silt, it dries in the shade.With the effect of relieving exterior syndrome and dispelling cold, wind-expelling pain-stopping is sensible, warming lung and resolving fluid.
For anemofrigid cold, have a headache, toothache, nasal congestion, allergic rhinitis, nasosinusitis, arthralgia pain due to rheumatism, sputum cough.We's asarum, as assistant
Medicine.
12, smilax is the dry rhizome of liliaceous plant smilacis glabra.Main product is in Guangdong, Hunan, Hubei, Zhejiang, river
The ground such as Soviet Union, Sichuan.Summer, the excavation of two season of autumn, remove fibrous root, cleaning, drying；Or fresh-cut flakiness is taken advantage of, it is dry.Its nature and flavor is sweet, light,
It is flat.Return liver, stomach.With removing toxic substances, dehumidifying, it is easing joint movement the effect of.For the limbs contraction caused by syphilis and mercury poisoning, muscles and bones
Pain；Damp and hot stranguria with turbid discharge, under, carbuncle swells, scrofula, mange.We's smilax, as adjutant.
13, rhizoma anemarrhenae is the dry rhizome of liliaceous plant rhizoma anemarrhenae.There is cultivation in main producing region all over China in Hebei.
Spring, the excavation of two season of autumn, remove fibrous root and silt, dry, practise and claim " RHIZOMA ANEMARRHENAE with peet "；Or crust is removed, it dries.Its is bitter in taste, sweet,
It is cold.Return lung, stomach, kidney channel.It is with clearing heat-fire, the effect of nourishing Yin and moistening dryness.For fever caused by exogenous pathogenic factors, hyperpyrexia polydipsia, lung heat is dry
Cough, osteopyrexia and fever, Heat Diabetes, dry constipation of intestines.We's rhizoma anemarrhenae, as adjutant,.
14, Rhizoma Gastrodiae is the dry tuber of orchid Rhizoma Gastrodiae.Main product is in Guizhou, Sichuan, Yunnan and other places.To secondary after the Beginning of Winter
Excavation before year is clear and bright, is cleaned immediately, is steamed thoroughly, is opened wide low temperature drying.Its nature and flavor sweet and neutral.Return liver warp.It puts down with Inflammation Zhijing
The effect of suppression liver-yang, dispelling wind and removing obstruction in the meridians.It twitches for child convulsion , Epilepsy epilepsys, lockjaw, dizziness of having a headache, hands and feet caused by paralysis, limbs fiber crops
Wood, arthralgia pain due to rheumatism.We's Rhizoma Gastrodiae, as adjutant,.
15, caulis piperis futokadsurae is the drying rattan of Piperaceae plant wind rattan.Main product is in Guangdong, Fujian, Taiwan, zhejiang and other places.
Summer, two season of autumn tap, and remove root, leaf, dry.Its nature and flavor is pungent, bitter, tepor.Return liver warp.With wind-damp dispelling, degrading the channel, stopping numbness pain
The effect of.For wind-cold-dampness arthralgia, podomere pain, muscle arteries and veins contraction, joint stuffiness.We use caulis piperis futokadsurae, as adjutant,.
16, caulis trachelospermi is the dry zone leaf rattan of apocynaceae plant trachelospermum jasminoide.Main product in Xuzhou, Nanjing, Zhenjiang,
Wuhu, Hubei Xiaogan, Qingdao；In addition, Guangdong, Guangxi are also produced.Winter to secondary spring is tapped, and is removed impurity, is dried.Its
It is bitter in taste, it is slightly cold.The thoughts of returning home, liver and kidney channel.It is with dispelling wind and removing obstruction in the meridians, the effect of cool blood detumescence.For beriberoid pyretic arthralgia, muscle arteries and veins contraction,
Soreness of waist and knee joint, larynx numbness, carbuncle swells, injury from falling down.We use caulis trachelospermi, as adjutant.
Square epheday intermedia, asarum assistant help monarch-minister drug eliminating cold to stop pain；Smilax assistant helps easing joint movement；Rhizoma anemarrhenae nourishing Yin and clearing heat assistant system with
The scorching disadvantage of upper drug.The effect of Rhizoma Gastrodiae dispelling wind and removing obstruction in the meridians relieves pain, and assistant helps Chinese ephedra, monkshood, asarum to reinforce temperature sun analgesic.Caulis piperis futokadsurae,
The analgesic of caulis trachelospermi dispelling wind and removing obstruction in the meridians is adjutant altogether to control its mark.
17, radix cyathulae is the dry root of amaranthaceous plant radix cyathulae.Main product is in Sichuan, Guizhou, Yunnan, Hebei, Shaanxi, lake
The ground such as south.Autumn, the excavation of two season of winter, remove removing LU, fibrous root and silt, dry or shine to half-dried, stacking backwash, then dry or dry.
Its nature and flavor is sweet, slight bitter, puts down.Return liver and kidney channel.The effect of it is easing joint movement with dispelling stasis of blood and stimulating the menstrual flow, inducing diuresis for treating strangurtia.For Amenorrhea abnormal pigmentary deposit on the skin
Lump in the abdomen, placenta retension, injury from falling down, arthralgia pain due to rheumatism, sufficient impotence muscle contraction, cards such as hematuria blood drenches.We use radix cyathulae, as adjuvant.
Radix cyathulae, which had both been helped, in side helps the above drug blood circulation and removing stasis, easing joint movement, and can draw all medicines and guide drugs to illness station, therefore makes for assistant
Medicine.
Complete square compatibility 5 receives Warming Yang and promoting blood circulation altogether, the function of removing obstruction in channels to relieve pain.For treating the diabete peripheral herve pathology category deficiency of yang
Cold solidifying, syndrome of blood stasis due to qi deficiency, clinical manifestation is four limbs spontaneous pain, acroanesthesia, cold limbs, the soft inability of limb, cacesthesia
Or decline；Or see that purplish tongue or dimness, arteries and veins are thin or thin puckery.
When decoction with high heat first（That is big fire）After boiling liquid, slow boiling is used instead（That is small fire）It is slow to decoct.
Beneficial effects of the present invention：
Therapeutic effect of the present invention is apparent, and Small side effects are uneasy to recur.According to for many years clinical experience and further investigation, we
Think that the main pathogenesis of diabete peripheral herve pathology is that the deficiency of Yin is scorching, prolonged illness damages healthy tendency, and YANG QI deficiency is yin-cold excess, trembles with fear
Blood coagulation arteries and veins, QI-blood circulation is unsmooth, and passages through which vital energy circulates mistake is foster caused, and it is soft four limbs spontaneous pain, acroanesthesia, cold limbs, limb occur
Powerless, cacesthesia or decline；Or see that purplish tongue or dimness, arteries and veins be thin or thin symptoms such as puckery.Product of the present invention aims at yang-energy blood
The stasis of blood, it is cold to coagulate train of thought and set.Results of animal confirmation, product energy repairing model rat sciatic nerve axonal degeneration of the present invention（It is de-
Myelin）Pathological change, accelerate the Sciatic Nerve Conduction Velocity of rat model, reduce in rat model sciatic nerve and red blood cell
Aldose reductase activity, sorbitol content, MDA contents, improve SOD activity, reduce rat model whole blood viscosity and whole blood also
Former viscosity；Acetic acid induced mice writhing response and thermostimulation induced mice pain reaction are can inhibit, sugar caused by streptozotocin is reduced
The blood glucose for urinating disease model rat in terms of several mechanism of diabete peripheral herve pathology treat globally for property.This hair
Bright is pure Chinese medicine, is had no toxic side effect, and adverse reaction is had no during rat is edible and during patient's use.It is prepared by the present invention
Method can maximumlly utilize the beneficiating ingredient of raw material.The preparation method of the present invention is protected to greatest extent in preparation process
Drug effect is held, beneficiating ingredient is retained, all Chinese medicine mutual compatibility in preparation process is merged, plays treatment diabetes
The purpose of peripheral neuropathy.
Specific implementation mode
Clinical manifestation：The diabete peripheral herve pathology category deficiency of yang is cold solidifying, syndrome of blood stasis due to qi deficiency, and clinical manifestation is that four limbs are spontaneous
The soft inability of pain, acroanesthesia, cold limbs, limb, cacesthesia or decline；Or see that purplish tongue or dimness, arteries and veins are thin or thin puckery.
Embodiment 1
It is radix aconiti lateralis preparata 10g, 15 g of cassia twig, 30 g of Radix Astragali, 12 g of ginseng, 15 g of Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong 10g, 10 g of Radix Angelicae Sinensis, 8 g of radix paeoniae rubra, red
Spend 9 g, 10 g of Chinese ephedra, 8 g of asarum, 16 g of smilax, 12 g of rhizoma anemarrhenae, 10 g of Rhizoma Gastrodiae, 14 g of caulis piperis futokadsurae, 15 g of caulis trachelospermi and river
13 g of the root of bidentate achyranthes.
The above 17 taste medicine, 100 DEG C of flowing steam sterilizations 30 minutes are ground into fine powder, and be sieved 100 mesh, by fine powder：Water=1:
0.3-0.8 ratios add water, stir evenly, and the water-bindered pill is made, dry, arrange to get.
Embodiment 2
It is 6 g of radix aconiti lateralis preparata, 21 g of cassia twig, 12 g of Radix Astragali, 18 g of ginseng, 6 g of Radix Salviae Miltiorrhizae, 18 g of Rhizoma Chuanxiong, 6 g of Radix Angelicae Sinensis, 12 g of radix paeoniae rubra, red
Spend 6 g, 18 g of Chinese ephedra, 3 g of asarum, 27 g of smilax, 6 g of rhizoma anemarrhenae, 18 g of Rhizoma Gastrodiae, 6 g of caulis piperis futokadsurae, 24 g of caulis trachelospermi and river ox
6 g of knee.
The above 17 taste medicine mixing takes 100 DEG C of 30% Chinese medicine flowing steam sterilization 30 minutes, is ground into fine powder, sieving 100
Mesh is spare, remaining 70% Chinese medicine adds water to cook secondary, the first pan-fried plus 1193g water, decocts 1 hour, and the second pan-fried plus 895g water is pan-fried
It boils 40 minutes, collecting decoction, filters, 70 DEG C of filtrate is concentrated into the clear cream that relative density is 1.15-1.25 g/cm3, is added above-mentioned
Cross 100 targeted fine powders, the concentration water-bindered pill is made in mixing, dry, arrange to get.
Embodiment 3
It is 18 g of radix aconiti lateralis preparata, 6 g of cassia twig, 45 g of Radix Astragali, 6 g of ginseng, 21 g of Radix Salviae Miltiorrhizae, 6 g of Rhizoma Chuanxiong, 18 g of Radix Angelicae Sinensis, 3 g of radix paeoniae rubra, red
Spend 15 g, 6 g of Chinese ephedra, 12 g of asarum, 6 g of smilax, 18 g of rhizoma anemarrhenae, 6 g of Rhizoma Gastrodiae, 24 g of caulis piperis futokadsurae, 6 g of caulis trachelospermi and river ox
21 g of knee.
Above-mentioned 17 taste medicinal material is taken to add water to cook secondary, the first pan-fried plus water 1896g is decocted 1 hour, the second pan-fried plus water 1422g,
It decocts 40 minutes, collecting decoction, filtration, ethyl alcohol, which is added, after filtrate concentration carries out alcohol precipitation, takes supernatant to recycle ethyl alcohol, and in 70 DEG C
It is 1.20-1.25g/cm3 clear creams to be concentrated into relative density.The lactose or dextrin of 2-5 times of clear cream weight is added, mixing is pelletized, and is done
It is dry to get.
Embodiment 4
15 g of radix aconiti lateralis preparata, 18 g of cassia twig, Radix Astragali 12g, 11 g of ginseng, 12 g of Radix Salviae Miltiorrhizae, 9 g of Rhizoma Chuanxiong, 8 g of Radix Angelicae Sinensis, radix paeoniae rubra 5g, safflower
9 g, 10 g of Chinese ephedra, 7 g of asarum, 18 g of smilax, 11 g of rhizoma anemarrhenae, 11 g of Rhizoma Gastrodiae, caulis piperis futokadsurae 13g, caulis trachelospermi 16 and radix cyathulae
10 g。
It takes above-mentioned 17 taste medicinal material that volume fraction is added to be that the extraction of 50-70% alcohol refluxs is secondary, adds ethyl alcohol 1365g for the first time, carry
It takes 2 hours, second plus ethyl alcohol 1365g, extracts 2 hours, merge extracting solution, filter, filtrate recycling ethanol, and in 70 DEG C of concentrations
To the clear cream that relative density is 1.20-1.25 g/cm3.The lactose or dextrin auxiliary material of 2-5 times of clear cream weight, mixing, system is added
Grain, it is dry to get.
Embodiment 5
9 g of radix aconiti lateralis preparata, cassia twig 20g, 31 g of Radix Astragali, 17 g of ginseng, 14 g of Radix Salviae Miltiorrhizae, 10 g of Rhizoma Chuanxiong, 10 g of Radix Angelicae Sinensis, 11 g of radix paeoniae rubra,
Safflower 8g, 10 g of Chinese ephedra, 4 g of asarum, 21 g of smilax, 7 g of rhizoma anemarrhenae, 7 g of Rhizoma Gastrodiae, caulis piperis futokadsurae 21g, 7 g of caulis trachelospermi and river ox
7 g of knee.
The above 17 taste medicinal material, Radix Astragali, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong are extracted three times with 50-70% alcohol refluxs, add 440g ethyl alcohol every time, carry
It takes 2 hours, filters, merging filtrate.Asarum, cassia twig, Radix Angelicae Sinensis steam distillation 4 hours, extract volatile oil, volatile oil times his ring
Dextrin inclusion, low temperature drying.Asarum, cassia twig, Radix Angelicae Sinensis carry the dregs of a decoction after oil and radix aconiti lateralis preparata, ginseng, radix paeoniae rubra, safflower, Chinese ephedra, soil Fu
Siberian cocklebur, rhizoma anemarrhenae, Rhizoma Gastrodiae, caulis piperis futokadsurae, caulis trachelospermi and radix cyathulae add water to cook 2-3 times, and every time plus water 1216g, decoction 1 hour merge
Decocting liquid, filtration, 60 DEG C of filtrate are concentrated into the clear cream that relative density is 1.10-1.15 g/cm3, add ethyl alcohol, make alcohol volume content
It up to 50-70%, places 24 hours, filtration, filtrate merges with above-mentioned alcohol extract, recycles ethyl alcohol, and be concentrated into relative density in 60 DEG C
For the clear cream of 1.10-1.15 g/cm3, spray drying or spray-drying process, dry particl is mixed with above-mentioned inclusion complex, in addition
The corrigent Steviosin of 0.2%-0.5% times of dry particl weight is stated, in addition stating the auxiliary material dextrin of 2-5 times of dry particl weight, mixing is done
Suppress grain to get.
Embodiment 6
It is 17 g of radix aconiti lateralis preparata, 11 g of cassia twig, 13 g of Radix Astragali, 14 g of ginseng, 15 g of Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong 12g, Radix Angelicae Sinensis 12g, 8 g of radix paeoniae rubra, red
Spend 10 g, Chinese ephedra 9g, 6 g of asarum, 17 g of smilax, 10 g of rhizoma anemarrhenae, Rhizoma Gastrodiae 13g, 20 g of caulis piperis futokadsurae, 20 g of caulis trachelospermi and river ox
14 g of knee.
The above 17 taste medicinal material, Radix Astragali, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong are that 50%-85% alcohol refluxs extract three times with volume fraction, are added every time
280g ethyl alcohol extracts 2 hours, filtration, merging filtrate；Asarum, cassia twig, Radix Angelicae Sinensis steam distillation 4 hours extract volatile oil；Carefully
Pungent, cassia twig, Radix Angelicae Sinensis carry the dregs of a decoction after oil and radix aconiti lateralis preparata, ginseng, radix paeoniae rubra, safflower, Chinese ephedra, smilax, rhizoma anemarrhenae, Rhizoma Gastrodiae, caulis piperis futokadsurae,
Caulis trachelospermi and radix cyathulae add water to cook 2-3 times, and every time plus water 1504g water, decoction 1 hour, collecting decoction filter, 60 DEG C of filtrate
It is concentrated into the clear cream that relative density is 1.10-1.15 g/cm3, adds ethyl alcohol, second containing alcohol volume content is made to reach 50%-80%, places 24
Hour, filtration, filtrate merges with above-mentioned alcohol extract, recycles ethyl alcohol, and it is 1.10-1.15 g/ to be concentrated into relative density in 60 DEG C
Volatile oil is added in the clear cream of cm3, and the corrigent Steviosin of clear cream weight 0.05%-0.25% is added, purified water is added to be deployed into relatively
Density is 1.10-1.15g/cm3Oral solution.
Clinical data：Tracking treatment DPN patients 760.Wherein, treatment sugar using the present invention
The treatment group 532 of the traditional Chinese medicine composition for treating of the sick peripheral neuropathy of urine, wherein male 312, women 220；Do not adopt
With the present invention treatment diabete peripheral herve pathology traditional Chinese medicine composition for treating control group 228, wherein male 136,
Women 92.
Diagnostic criteria：Meet diabete peripheral herve pathology diagnostic criteria, classical symptom includes：Four limbs caused by diabetes
Spontaneous sexual anesthesia is sent out cool, pain（Such as needle thorn, knife cut, the sample pain that shocks by electricity or angina, secret anguish, cusalgia）, hyperalgia, limb is soft
It is powerless.Cacesthesia or decline（Such as whole body has that myrmeciasis, worm climb sense, pruitus, biped step on cotton sense or ankle socks sense）
Typical sign：Muscular strength decline or disappearance, amyotrophia etc., vibration sense（128HZ）, light touch（Cotton-wool, 10g nylon yarns）, needle
It pierces feel, temperature sensation, tendon reflex decrease or disappears.Autonomic nerve is damaged for example lossless symptom, increased heart rate, orthostatic hypotension etc..
Electrophysiology（Electromyogram）：1, wave amplitude lowers 2, conduct velocity, disappearance
Therapeutic scheme：The Chinese medicine composition of the oral treatment of the embodiment of the present invention 1 diabete peripheral herve pathology of patient, daily three
It is secondary, each taking 8 grams of granule or oral solution 20ml or water-bindered pill 9g or water-bindered pill 6g is concentrated, after meal 30 minutes warm water delivery services, 8
All as a treatment course, control groups:500 μ g of Methycobal take orally day three times.Check Electrophysiology（Electromyogram）, statistics treatment
As a result.
Curative effect determinate standard:
It cures：Symptom, sign disappear, electromyography：Nerve conduction velocity is normal
It is effective：Four limbs sensory disturbance is numb, send out cool, pain largely disappears, and limb end is slightly numb.Vibration sense（128HZ）、
Light touch（Cotton-wool, 10g nylon yarns）, the feel of needle thorn, temperature sensation, tendon reflex obviously restore.Electromyogram：Nerve conduction velocity significantly changes
It is kind
Effectively：Four limbs sensory disturbances is numb, send out cool, pain is substantially reduced, vibration sense（128HZ）, light touch（Cotton-wool, 10g nylon
Silk）, the feel of needle thorn, temperature sensation, tendon reflex restored.Electromyogram：Nerve conduction velocity makes moderate progress
In vain：Symptom, sign, electromyogram is without improvement
Statistical result is shown in Table 1
Table 1
P ＜ 0.05, tool is statistically significant
Shown by above-mentioned data：The traditional Chinese medicine composition for treating Diabetic Peripheral god of the treatment diabete peripheral herve pathology of the present invention
Through lesion total effective rate 94%；Control group total effective rate 66.67%.Improve numb, cool, pain symptom, improvement damaged peripheral nerves
Conduction function be substantially better than control group.Suitable for diabete peripheral herve pathology category qi deficiency to blood stasis, cold solidifying train of thought person.The medication phase
Between, it is safe and reliable, without any side effects.It is the active drug for treating diabete peripheral herve pathology.
The foregoing description of the disclosed embodiments enables those skilled in the art to implement or use the present invention.
Various modifications to these embodiments will be apparent to those skilled in the art, as defined herein
General Principle can be realized in other embodiments without departing from the spirit or scope of the present invention.Therefore, of the invention
It is not intended to be limited to the embodiments shown herein, and is to fit to and the principles and novel features disclosed herein phase one
The widest range caused.
Claims (9)
1. a kind of Chinese medicine composition for treating diabete peripheral herve pathology, which is characterized in that including following parts by weight
Raw material components：6-18 parts of radix aconiti lateralis preparata, 6-21 parts of cassia twig, 12-45 parts of Radix Astragali, 6-18 parts of ginseng, 6-21 parts of Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong 6-18
Part, 6-18 parts of Radix Angelicae Sinensis, 3-12 parts of radix paeoniae rubra, 6-15 parts of safflower, 6-18 parts of Chinese ephedra, 3-12 parts of asarum, 6-27 parts of smilax, rhizoma anemarrhenae 6-
18 parts and 6-18 parts of Rhizoma Gastrodiae.
2. a kind of Chinese medicine composition for treating diabete peripheral herve pathology according to claim 1, feature exist
In including the raw material components of following parts by weight：6-18 parts of radix aconiti lateralis preparata, 6-21 parts of cassia twig, 12-45 parts of Radix Astragali, 6-18 parts of ginseng, pellet
6-21 parts of ginseng, 6-18 parts of Rhizoma Chuanxiong, 6-18 parts of Radix Angelicae Sinensis, 3-12 parts of radix paeoniae rubra, 6-15 parts of safflower, 6-18 parts of Chinese ephedra, 3-12 parts of asarum, soil
6-21 parts of 6-27 parts of Poria cocos, 6-18 parts of rhizoma anemarrhenae, 6-18 parts of Rhizoma Gastrodiae, 6-24 parts of caulis piperis futokadsurae, 6-24 parts of caulis trachelospermi and radix cyathulae.
3. a kind of Chinese medicine composition for treating diabete peripheral herve pathology according to claim 2, feature exist
In including the raw material components of following parts by weight：10 parts of radix aconiti lateralis preparata, 15 parts of cassia twig, 30 parts of Radix Astragali, 12 parts of ginseng, 15 parts of Radix Salviae Miltiorrhizae, river
10 parts of rhizome of chuanxiong, 10 parts of Radix Angelicae Sinensis, 8 parts of radix paeoniae rubra, 9 parts of safflower, 10 parts of Chinese ephedra, 8 parts of asarum, 16 parts of smilax, 12 parts of rhizoma anemarrhenae, Rhizoma Gastrodiae 10
13 parts of part, 14 parts of caulis piperis futokadsurae, 15 parts of caulis trachelospermi and radix cyathulae.
4. a kind of preparation side of Chinese medicine composition for treating diabete peripheral herve pathology as described in claim 1-3
Method, which is characterized in that the Chinese medicine material weighed by weight, 100 DEG C of flowing steam sterilizations 30 minutes are dried, crushed into fine powder,
Be sieved 100 mesh, by fine powder：Water weight ratio is 1:The ratio of 0.3-0.8 adds water, stirs evenly, and the water-bindered pill is made, dry, arranges, i.e.,
.
5. a kind of preparation side of Chinese medicine composition for treating diabete peripheral herve pathology as described in claim 1-3
Method, which is characterized in that include the following steps：
Step 1：The Chinese medicine material mixing weighed by weight takes 100 DEG C of 30% Chinese medicine flowing steam sterilization 30 minutes, is ground into
Fine powder, 100 mesh of sieving are spare；
Step 2：Remaining 70% Chinese medicine adds water to cook secondary, and first decocts plus water is 8 times of 70% Chinese medicine weight amounts, decocts 1 hour,
Second decocts 6 times of amounts for adding that water is 70% Chinese medicine weight, decocts 40 minutes, collecting decoction, filtration, 70 DEG C of filtrate is concentrated into relatively close
Degree is 1.15-1.25 g/cm3, and the fine powder after step 1 sieving is added, and the concentration water-bindered pill is made in mixing, dry, arrange to get.
6. a kind of preparation side of Chinese medicine composition for treating diabete peripheral herve pathology as described in claim 1-3
Method, which is characterized in that the Chinese medicine material mixing weighed by weight, first decocts 8 times of amounts for adding that water is Chinese medicine material total weight, decocts
It boils 1 hour, second decocts 6 times of amounts for adding that water is Chinese medicine material total weight, decocts 40 minutes, collecting decoction, filtration, after filtrate concentrates
Ethyl alcohol is added, it is 50%-80% to make the volume content of ethyl alcohol, and the ethyl alcohol that the ethyl alcohol is 95% carries out alcohol precipitation, and supernatant is taken to recycle second
Alcohol, and it is 1.20-1.25 g/cm3 clear creams to be concentrated into relative density, the temperature of concentration is 70 DEG C；Clear cream weight is added in clear cream
2-5 times of lactose or dextrin, mixing, granulation, it is dry to get.
7. a kind of preparation side of Chinese medicine composition for treating diabete peripheral herve pathology as described in claim 1-3
Method, which is characterized in that the Chinese medicine material mixing weighed by weight, it is that the extraction of 50-70% alcohol refluxs is secondary to add volume fraction,
6-8 times that amount of alcohol is Chinese medicine material total weight is added for the first time to measure, extracts 2 hours, it is that Chinese medicine is former that second, which is added amount of alcohol,
6-8 times of material total weight is measured, and is extracted 2 hours, merges extracting solution, filtration, it is 1.20-1.25 that 70 DEG C of filtrate, which is concentrated into relative density,
G/cm3 clear creams；Be added the lactose or dextrin of 2-5 times of clear cream weight in clear cream, mixing, granulation, dry to get.
8. a kind of preparation method as described in claim 1 for treating the Chinese medicine composition of diabete peripheral herve pathology,
It is characterized by comprising the following steps：
Step 1：The Chinese medicine material weighed by weight, Radix Astragali, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong are that 50-70% alcohol refluxs carry with volume fraction
It takes three times, adds 6-8 times of Radix Astragali, Radix Salviae Miltiorrhizae and Rhizoma Chuanxiong total weight to measure ethyl alcohol every time, extract 2 hours, filtration, merging filtrate；
Step 2：Asarum, cassia twig, Radix Angelicae Sinensis steam distillation extract volatile oil 4 hours, and volatile oil betadex inclusion is done
It is dry；
Step 3：Asarum, cassia twig, Radix Angelicae Sinensis carry the dregs of a decoction after oil and remaining Chinese medicine material adds water to cook 2-3 times, and every time plus water is thin
Pungent, cassia twig, Radix Angelicae Sinensis put forward 8 times of amounts of the dregs of a decoction and remaining Chinese medicine material total weight after oil, decoct 1 hour, collecting decoction, filtration,
Filtrate is concentrated into the clear cream that relative density is 1.10-1.15 g/cm3 in 60 DEG C, and ethyl alcohol is added to make the volume content of ethyl alcohol in liquid
50-70% is placed 24 hours, and filtration, filtrate merges with above-mentioned alcohol extract, recycles ethyl alcohol, and be concentrated into 1.10-1.15 in 60 DEG C
The clear cream of g/cm3, spray drying or spray-drying process；
Step 4：Dry particl made from step 3 is mixed with inclusion complex made from step 2, and above-mentioned dry particl weight 0.1%- is added
0.8% corrigent Steviosin or aspartame, in addition stating the auxiliary material lactose or dextrin of 1-5 times of dry particl weight, mixing, dry-pressing
Granulation to get.
9. a kind of preparation side of Chinese medicine composition for treating diabete peripheral herve pathology as described in claim 1-3
Method, which is characterized in that step 1：The Chinese medicine material weighed by weight, Radix Astragali, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong are 50%-85% with volume fraction
Alcohol reflux extracts three times, and every time plus 6-8 times of Radix Astragali, Radix Salviae Miltiorrhizae and Rhizoma Chuanxiong total weight measure ethyl alcohol, extract 2 hours, and filtration merges filter
Liquid；
Step 2：Asarum, cassia twig, Radix Angelicae Sinensis steam distillation 4 hours extract volatile oil；
Step 3：Asarum, cassia twig, Radix Angelicae Sinensis carry the dregs of a decoction after oil and remaining Chinese medicine adds water to cook 2-3 times, every time plus water be asarum,
Cassia twig, Radix Angelicae Sinensis put forward 8 times of amounts of the dregs of a decoction and remaining Chinese medicine weight after oil, decoct 1 hour, collecting decoction, filtration, 60 DEG C of filtrate is dense
It is reduced to the clear cream that relative density is 1.10-1.15, adds ethyl alcohol, alcohol volume content is made to reach 50%-85%, is placed 24 hours, filtration,
Filtrate merges with above-mentioned alcohol extract, recycles ethyl alcohol, and the clear cream of relative density 1.10-1.15 g/cm3 is concentrated into 60 DEG C, adds
The volatile oil for entering step 2 is added the corrigent Steviosin or aspartame of above-mentioned clear cream weight 0.05%-0.25%, adds purified water
It is 1.10-1.15g/cm to be deployed into relative density3Oral solution.
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| CN113813330A (en) * | 2021-10-03 | 2021-12-21 | 王钢柱 | Industrial preparation method of traditional Chinese medicine composition for preventing and treating diabetic peripheral neuropathy and product thereof |
| CN115837058A (en) * | 2022-10-27 | 2023-03-24 | 江苏省中医院 | Traditional Chinese medicine composition, preparation thereof and application of traditional Chinese medicine composition in medicine for treating diabetic peripheral neuropathy |
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| CN113813330A (en) * | 2021-10-03 | 2021-12-21 | 王钢柱 | Industrial preparation method of traditional Chinese medicine composition for preventing and treating diabetic peripheral neuropathy and product thereof |
| CN115837058A (en) * | 2022-10-27 | 2023-03-24 | 江苏省中医院 | Traditional Chinese medicine composition, preparation thereof and application of traditional Chinese medicine composition in medicine for treating diabetic peripheral neuropathy |
| CN115837058B (en) * | 2022-10-27 | 2023-09-29 | 江苏省中医院 | Traditional Chinese medicine composition, preparation thereof and application of traditional Chinese medicine composition in preparation of medicines for treating diabetic peripheral neuropathy |
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