CN101194958B - Method for preparing decocted ointment for treating headache - Google Patents
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- CN101194958B CN101194958B CN2006101299482A CN200610129948A CN101194958B CN 101194958 B CN101194958 B CN 101194958B CN 2006101299482 A CN2006101299482 A CN 2006101299482A CN 200610129948 A CN200610129948 A CN 200610129948A CN 101194958 B CN101194958 B CN 101194958B
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- 206010019233 Headaches Diseases 0.000 title claims abstract description 23
- 231100000869 headache Toxicity 0.000 title claims abstract description 23
- 238000000034 method Methods 0.000 title claims abstract description 9
- 239000002674 ointment Substances 0.000 title description 3
- 241000218176 Corydalis Species 0.000 claims abstract description 21
- 238000002360 preparation method Methods 0.000 claims abstract description 14
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 73
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 claims description 20
- 241000217407 Margaritifera Species 0.000 claims description 12
- 239000000706 filtrate Substances 0.000 claims description 12
- 210000000582 semen Anatomy 0.000 claims description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 12
- 238000010992 reflux Methods 0.000 claims description 11
- 230000006837 decompression Effects 0.000 claims description 10
- 238000004064 recycling Methods 0.000 claims description 10
- 239000012467 final product Substances 0.000 claims description 9
- 241000382455 Angelica sinensis Species 0.000 abstract 1
- 241000758794 Asarum Species 0.000 abstract 1
- 244000037364 Cinnamomum aromaticum Species 0.000 abstract 1
- 235000014489 Cinnamomum aromaticum Nutrition 0.000 abstract 1
- 241000112528 Ligusticum striatum Species 0.000 abstract 1
- 244000236658 Paeonia lactiflora Species 0.000 abstract 1
- 235000008598 Paeonia lactiflora Nutrition 0.000 abstract 1
- 244000179560 Prunella vulgaris Species 0.000 abstract 1
- 235000010674 Prunella vulgaris Nutrition 0.000 abstract 1
- 239000003814 drug Substances 0.000 description 37
- 229940079593 drug Drugs 0.000 description 15
- 230000000694 effects Effects 0.000 description 6
- 239000008280 blood Substances 0.000 description 5
- 210000004369 blood Anatomy 0.000 description 5
- 239000008187 granular material Substances 0.000 description 5
- 239000002671 adjuvant Substances 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 239000000843 powder Substances 0.000 description 4
- 239000002552 dosage form Substances 0.000 description 3
- 238000000605 extraction Methods 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 229940095559 cafergot Drugs 0.000 description 2
- CJMJLDQKTOJACI-SEUSHGJOSA-N chembl2448612 Chemical compound OC(=O)C(O)C(O)C(O)=O.C([C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@@](C(N21)=O)(C)NC(=O)[C@H]1CN([C@H]2C(C=3C=CC=C4NC=C(C=34)C2)=C1)C)C1=CC=CC=C1.C([C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@@](C(N21)=O)(C)NC(=O)[C@H]1CN([C@H]2C(C=3C=CC=C4NC=C(C=34)C2)=C1)C)C1=CC=CC=C1 CJMJLDQKTOJACI-SEUSHGJOSA-N 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 238000004090 dissolution Methods 0.000 description 2
- 230000000857 drug effect Effects 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 208000013403 hyperactivity Diseases 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 239000006187 pill Substances 0.000 description 2
- 239000002244 precipitate Substances 0.000 description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- PUQSUZTXKPLAPR-UJPOAAIJSA-N Gastrodin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=C(CO)C=C1 PUQSUZTXKPLAPR-UJPOAAIJSA-N 0.000 description 1
- 206010061245 Internal injury Diseases 0.000 description 1
- 208000019695 Migraine disease Diseases 0.000 description 1
- UEDUENGHJMELGK-HYDKPPNVSA-N Stevioside Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UEDUENGHJMELGK-HYDKPPNVSA-N 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 210000001627 cerebral artery Anatomy 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000007907 direct compression Methods 0.000 description 1
- 239000008298 dragée Substances 0.000 description 1
- 239000006196 drop Substances 0.000 description 1
- 238000001647 drug administration Methods 0.000 description 1
- -1 electuary Substances 0.000 description 1
- 239000002662 enteric coated tablet Substances 0.000 description 1
- 239000003172 expectorant agent Substances 0.000 description 1
- 230000003419 expectorant effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000007941 film coated tablet Substances 0.000 description 1
- SMANXXCATUTDDT-QPJJXVBHSA-N flunarizine Chemical compound C1=CC(F)=CC=C1C(C=1C=CC(F)=CC=1)N1CCN(C\C=C\C=2C=CC=CC=2)CC1 SMANXXCATUTDDT-QPJJXVBHSA-N 0.000 description 1
- 229960000326 flunarizine Drugs 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 230000009545 invasion Effects 0.000 description 1
- 208000028867 ischemia Diseases 0.000 description 1
- 238000011031 large-scale manufacturing process Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 206010027599 migraine Diseases 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 238000005325 percolation Methods 0.000 description 1
- 239000011505 plaster Substances 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 238000007560 sedimentation technique Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000007940 sugar coated tablet Substances 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 230000024883 vasodilation Effects 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 238000003809 water extraction Methods 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
Abstract
The invention provides a soft extract for curing headache and a process for preparation. Angelica sinensis, ligusticum wallichii, white peony root, radix rehmanniae, koxtox, milettia reticulata, prunella vulgaris, cassia seeds, pearl shell, rhizoma corydalis and asarum are prepared into extractum after being extracted in a certain method.
Description
Technical field
The present invention relates to field of medicaments, particularly, relate to a kind of soft extract for the treatment of headache and preparation method thereof.
Background technology
Headache is a kind of commonly encountered diseases, though there is the part Chinese and western drugs to use, effect is all not satisfactory, and especially to the medicine of the headache due to hyperactivity of liver-YANG for the treatment of blood deficiency, blood stasis type, the curative effect of medicine and drug effect speed affect the key factor of patients ' life quality especially.Now the Western medicine for the treatment of headache commonly used has cafergot, and it is a kind of vasodilation, is only suitable in cerebral artery ischemia expectorant sick.Its mechanism of action of flunarizine soft extract of producing in 1988 is optionally to suppress calcium to enter cell, to reduce the contraction of vein.The Chinese patent medicine of the at present treatment of report headache has ZHENGTIAN WAN, it is the Chinese medicine and western medicine side of closing, and its mechanism is blood circulation promoting and blood stasis dispelling, and is furnished with the analgesic of Western medicine, this medicine is only suitable in headache due to invasion of exogenous pathogens and so on, to the headache of the internal injury type of traditional Chinese medical science appellation, blood deficiency and blood stasis headache due to hyperactivity of liver-YANG poor effect then.
The Chinese medicine of at present treatment headache is a lot, and dosage form mostly is electuary, granule, and granule exists dissolution velocity slower, takes dose large, and mouthfeel for oral administration is not good, takes and carry the shortcomings such as inconvenience.As the applying date be 1993.1.9, application number is 93100050.5, Granted publication number is CN1047938C, denomination of invention is a kind of patent application for the treatment of the Chinese medicine of headache, this invention provides a kind of Chinese medicine granules for the treatment of headache, although this granule curative effect determines and than the decoction taking convenience, dissolution velocity more still makes its use be restricted.
Soft extract keeps the initial condition after the extract drugs, and its form does not need adjuvant substantially between between liquid and solid forms, be suitable for accurate medication.
Summary of the invention
The purpose of this invention is to provide a kind of preparation method for the treatment of the soft extract of headache.
Medicine of the present invention can adopt the preparation of Chinese medicine preparation conventional method.Effective ingredient of the present invention can adopt following methods: water extraction, decoction and alcohol sedimentation technique, extraction, infusion process, percolation, reflux extraction, continuous circumfluence extraction method, macroreticular resin absorbing method preparation.Also these crude drug can be ground into the powder mix homogeneously makes powder and takes after mixing it with water; Also can be with these medicines together decocting, then the condensed water decocting liquid is made oral liquid; Also can the raw materials used medicated powder of medicine of the present invention is broken, with crude drug ground ingredients and adjuvant mix homogeneously, direct compression.The present invention can adopt the said extracted method, make said dosage form on any pharmaceutics; Such as tablet, sugar coated tablet, film coated tablet, enteric coated tablet, soft extract, oral liquid, suck the dosage forms such as agent, granule, electuary, pill, powder, unguentum, sublimed preparation, suspensoid, solution, ointment, plaster, spray, drop pill, soft soft extract, but preferably adopt following method to extract crude drug, and be prepared into soft extract, but this is not construed as limiting the invention.
The present invention treats the preparation method of the soft extract of headache, comprises the steps:
Get Radix Angelicae Sinensis 4～9 weight portions, Rhizoma Chuanxiong 4～9 weight portions, the Radix Paeoniae Alba 2～8 weight portions, Radix Rehmanniae Preparata 2～8 weight portions, Ramulus Uncariae Cum Uncis 10～15 weight portions, Caulis Spatholobi 10～15 weight portions, Spica Prunellae 10～15 weight portions, Semen Cassiae 10～15 weight portions, Concha Margaritifera 10～15 weight portions, Rhizoma Corydalis 4～9 weight portions, Herba Asari 0.5～2 weight portion for subsequent use; Above ten simply, and Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Paeoniae Alba, Rhizoma Corydalis add ethanol, reflux, and backflow in addition device stores; Medicinal residues and the Six-elements such as all the other Radix Rehmanniae Preparata except Ramulus Uncariae Cum Uncis decoct with water 2～4 times, add Ramulus Uncariae Cum Uncis, collecting decoction, concentrating under reduced pressure when decocting the last time, add the ethanol precipitate with ethanol, leave standstill, filter, filtrate and above-mentioned backflow merge, and decompression recycling ethanol and concentrated filtrate are condensed into extractum and get final product.
Preferred the present invention treats the preparation method of the soft soft extract of headache, comprises the steps:
Get Radix Angelicae Sinensis 5～7 weight portions, Rhizoma Chuanxiong 5～7 weight portions, the Radix Paeoniae Alba 4～6 weight portions, Radix Rehmanniae Preparata 4～6 weight portions, Ramulus Uncariae Cum Uncis 12～14 weight portions, Caulis Spatholobi 12～14 weight portions, Spica Prunellae 12～14 weight portions, Semen Cassiae 12～14 weight portions, Concha Margaritifera 12～14 weight portions, Rhizoma Corydalis 5～7 weight portions, Herba Asari 1～1.5 weight portion for subsequent use; Above ten simply, and Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Paeoniae Alba, Rhizoma Corydalis add 60～80% ethanol, reflux 1～3 hour, and backflow in addition device stores; Medicinal residues and the Six-elements such as all the other Radix Rehmanniae Preparata except Ramulus Uncariae Cum Uncis decoct with water 2～4 times, each 0.5～2 hour, add Ramulus Uncariae Cum Uncis when decocting the last time, collecting decoction, being evaporated to 45～60 ℃, relative density is 1.05～1.15, adding ethanol makes and contains alcohol amount and reach 60～70%, left standstill 18～30 hours, and filtered, filtrate and above-mentioned backflow merge, decompression recycling ethanol and to be concentrated into 45～60 ℃, relative density be 1.05～1.25 thick paste, and get final product.
Best the present invention treats the preparation method of the soft soft extract of headache, comprises the steps:
Get Radix Angelicae Sinensis 6.75 weight portions, Rhizoma Chuanxiong 6.75 weight portions, the Radix Paeoniae Alba 5.4 weight portions, Radix Rehmanniae Preparata 5.4 weight portions, Ramulus Uncariae Cum Uncis 13.5 weight portions, Caulis Spatholobi 13.5 weight portions, Spica Prunellae 13.5 weight portions, Semen Cassiae 13.5 weight portions, Concha Margaritifera 13.5 weight portions, Rhizoma Corydalis 6.75 weight portions, Herba Asari 1.34 weight portions for subsequent use; Above ten simply, and Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Paeoniae Alba, Rhizoma Corydalis add 70% ethanol, reflux 2 hours, and backflow in addition device stores; Medicinal residues and the Six-elements such as all the other Radix Rehmanniae Preparata except Ramulus Uncariae Cum Uncis decoct with water three times, each 1 hour, when decocting for the third time, add Ramulus Uncariae Cum Uncis, collecting decoction, being evaporated to 55 ℃, relative density is 1.09～1.13, adding ethanol makes and contains alcohol amount and reach 65%, left standstill 24 hours, and filtered, filtrate and above-mentioned backflow merge, decompression recycling ethanol and to be concentrated into 55 ℃, relative density be 1.10～1.20 thick paste, and get final product.
Ingredients of the present invention can increase or reduce according to corresponding ratio when producing, can be with kilogram or take ton as unit such as large-scale production, small-scale production also can be in grams, and weight can increase or reduce, but the crude drug material weight proportion constant rate between each composition.
Above each single medicinal material, especially adjuvant drug in forming, make medicine or adjuvant drug and make medicine, can be replaced by the suitable Chinese medicine with the identical property of medicine, effect individually or simultaneously, replace rear Chinese medicine preparation and drug effect thereof constant.
Medicine of the present invention can be determined usage and dosage according to patient's situation in use, but every day 1-3 time, and every day, each crude drug consumption was as the criterion with the state-promulgated pharmacopoeia dosage, was no more than the pharmacopeia ormal weight.
The soft extract convenient drug administration that the present invention is prepared is suitable for old patient and takes.Medicine of the present invention confirms to have the medicine for the treatment of headache through lot of experiments.
Get according to embodiment 3 and obtain medicine of the present invention, through the outpatient service clinical trial: use 95 examples, male's 35 examples wherein. women's 60 examples, age 16-76 year, the course of disease 5 months～34 years is headache or migraine, all cases impassivity system exception sign, wherein the part patient all once took cafergot, its clinical observation result of the medicines such as gastrodine, somedon:
Clinical practice proves, medicine of the present invention has the effect of good treatment headache, and its total effective rate is 90.5%.
The specific embodiment
Embodiment 1:
Get Radix Angelicae Sinensis 4g, Rhizoma Chuanxiong 4g, Radix Paeoniae Alba 2g, Radix Rehmanniae Preparata 2g, Ramulus Uncariae Cum Uncis 10g, Caulis Spatholobi 10g, Spica Prunellae 10g, Semen Cassiae 10g, Concha Margaritifera 10g, Rhizoma Corydalis 4g, Herba Asari 0.5g is for subsequent use;
Above ten simply, and Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Paeoniae Alba, Rhizoma Corydalis add ethanol, reflux, and backflow in addition device stores; Medicinal residues and the Six-elements such as all the other Radix Rehmanniae Preparata except Ramulus Uncariae Cum Uncis decoct with water three times, add Ramulus Uncariae Cum Uncis, collecting decoction, concentrating under reduced pressure when decocting for the third time, add the ethanol precipitate with ethanol, leave standstill, filter, filtrate and above-mentioned backflow merge, decompression recycling ethanol and concentrated filtrate are condensed into soft extract, and get final product.
Embodiment 2:
Get Radix Angelicae Sinensis 7g, Rhizoma Chuanxiong 5g, Radix Paeoniae Alba 6g, Radix Rehmanniae Preparata 4g, Ramulus Uncariae Cum Uncis 14g, Caulis Spatholobi 12g, Spica Prunellae 14g, Semen Cassiae 12g, Concha Margaritifera 14g, Rhizoma Corydalis 5g, Herba Asari 1g is for subsequent use;
Above ten simply, and Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Paeoniae Alba, Rhizoma Corydalis add 70% ethanol, reflux 2 hours, and backflow in addition device stores; Medicinal residues and the Six-elements such as all the other Radix Rehmanniae Preparata except Ramulus Uncariae Cum Uncis decoct with water three times, each 1 hour, when decocting for the third time, add Ramulus Uncariae Cum Uncis, collecting decoction, being evaporated to relative density is 1.09～1.13 (55 ℃), adds ethanol and makes and contain alcohol amount and reach 65%, left standstill 24 hours, filter filtrate and the merging of above-mentioned backflow, decompression recycling ethanol and to be concentrated into relative density be the soft extract of 1.10～1.20 (55 ℃) and get final product.
Embodiment 3:
Get Radix Angelicae Sinensis 6.75g, Rhizoma Chuanxiong 6.75g, Radix Paeoniae Alba 5.4g, Radix Rehmanniae Preparata 5.4g, Ramulus Uncariae Cum Uncis 13.5g, Caulis Spatholobi 13.5g, Spica Prunellae 13.5g, Semen Cassiae 13.5g, Concha Margaritifera 13.5g, Rhizoma Corydalis 6.75g, Herba Asari 1.34g is for subsequent use;
Above ten simply, and Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Paeoniae Alba, Rhizoma Corydalis add 70% ethanol, reflux 2 hours, and backflow in addition device stores; Medicinal residues and the Six-elements such as all the other Radix Rehmanniae Preparata except Ramulus Uncariae Cum Uncis decoct with water three times, each 1 hour, when decocting for the third time, add Ramulus Uncariae Cum Uncis, collecting decoction, being evaporated to relative density is 1.09～1.13 (55 ℃), adding ethanol makes and contains alcohol amount and reach 65%, left standstill 24 hours, and filtered, filtrate and above-mentioned backflow merge, decompression recycling ethanol also is concentrated into the thick paste that relative density is 1.10～1.20 (55 ℃), and get final product.
Embodiment 4:
Get Radix Angelicae Sinensis 405.6g, Rhizoma Chuanxiong 405.6g, Radix Paeoniae Alba 324.3g, Radix Rehmanniae Preparata 324.3g, Ramulus Uncariae Cum Uncis 810.8g, Caulis Spatholobi 810.8g, Spica Prunellae 810.8g, Semen Cassiae 810.8g, Concha Margaritifera 810.8g, Rhizoma Corydalis 405.6g, Herba Asari 80.8g is for subsequent use;
Above ten simply, and Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Paeoniae Alba, Rhizoma Corydalis add 70% ethanol, reflux 2 hours, and backflow in addition device stores; Medicinal residues and the Six-elements such as all the other Radix Rehmanniae Preparata except Ramulus Uncariae Cum Uncis decoct with water three times, each 1 hour, when decocting for the third time, add Ramulus Uncariae Cum Uncis, collecting decoction, being evaporated to relative density is 1.09～1.13 (55 ℃), adding ethanol makes and contains alcohol amount and reach 65%, left standstill 24 hours, and filtered, filtrate and above-mentioned backflow merge, decompression recycling ethanol also is concentrated into the thick paste that relative density is 1.10～1.20 (55 ℃), and get final product.
Embodiment 5
Get in proportion Radix Angelicae Sinensis 338g, Rhizoma Chuanxiong 338g, Radix Paeoniae Alba 170.3g, Radix Rehmanniae Preparata 270.3g, Ramulus Uncariae Cum Uncis 675.7g, Caulis Spatholobi 675.7g, Spica Prunellae 675.7g, Semen Cassiae 675.7g, Concha Margaritifera 675.7g, Rhizoma Corydalis 338g, Herba Asari 67.3g, above ten simply, Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Paeoniae Alba, Rhizoma Corydalis add 70% ethanol, reflux 2 hours, backflow in addition device store; Medicinal residues and the Six-elements such as all the other Radix Rehmanniae Preparata except Ramulus Uncariae Cum Uncis decoct with water three times, each 1 hour, add Ramulus Uncariae Cum Uncis when decocting for the third time, collecting decoction, being evaporated to relative density is 1.09～1.13 (55 ℃), adds ethanol and makes and contain alcohol amount and reach 65%, leaves standstill 24 hours, filter, filtrate and above-mentioned backflow merge, and decompression recycling ethanol and to be concentrated into relative density be 1.10～1.20 (55 ℃) adds an amount of steviosin, mixing gets the thick paste agent.
Claims (2)
1. a preparation method for the treatment of the soft extract of headache is characterized in that,
Get Radix Angelicae Sinensis 5～7 weight portions, Rhizoma Chuanxiong 5～7 weight portions, the Radix Paeoniae Alba 4～6 weight portions, Radix Rehmanniae Preparata 4～6 weight portions, Ramulus Uncariae Cum Uncis 12～14 weight portions, Caulis Spatholobi 12～14 weight portions, Spica Prunellae 12～14 weight portions, Semen Cassiae 12～14 weight portions, Concha Margaritifera 12～14 weight portions, Rhizoma Corydalis 5～7 weight portions, Herba Asari 1～1.5 weight portion for subsequent use; Above ten simply, and Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Paeoniae Alba, Rhizoma Corydalis add 60～80% ethanol, reflux 1～3 hour, and backflow in addition device stores; Medicinal residues and Radix Rehmanniae Preparata, Caulis Spatholobi, Spica Prunellae, Semen Cassiae, Concha Margaritifera, Herba Asari decoct with water 2～4 times, each 0.5～2 hour, add Ramulus Uncariae Cum Uncis when decocting the last time, collecting decoction, being evaporated to 45～60 ℃, relative density is 1.05～1.15, adding ethanol makes and contains alcohol amount and reach 60～70%, left standstill 18～30 hours, and filtered, filtrate and above-mentioned backflow merge, decompression recycling ethanol and to be concentrated into 45～60 ℃, relative density be 1.05～1.25 thick paste, and get final product.
2. treat as claimed in claim 1 the preparation method of the soft extract of headache, it is characterized in that, method is as follows:
Get Radix Angelicae Sinensis 6.75 weight portions, Rhizoma Chuanxiong 6.75 weight portions, the Radix Paeoniae Alba 5.4 weight portions, Radix Rehmanniae Preparata 5.4 weight portions, Ramulus Uncariae Cum Uncis 13.5 weight portions, Caulis Spatholobi 13.5 weight portions, Spica Prunellae 13.5 weight portions, Semen Cassiae 13.5 weight portions, Concha Margaritifera 13.5 weight portions, Rhizoma Corydalis 6.75 weight portions, Herba Asari 1.34 weight portions for subsequent use; Above ten simply, and Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Paeoniae Alba, Rhizoma Corydalis add 70% ethanol, reflux 2 hours, and backflow in addition device stores; Medicinal residues and Radix Rehmanniae Preparata, Caulis Spatholobi, Spica Prunellae, Semen Cassiae, Concha Margaritifera, Herba Asari decoct with water three times, each 1 hour, when decocting for the third time, add Ramulus Uncariae Cum Uncis, collecting decoction, being evaporated to 55 ℃, relative density is 1.09～1.13, adding ethanol makes and contains alcohol amount and reach 65%, left standstill 24 hours, and filtered, filtrate and above-mentioned backflow merge, decompression recycling ethanol and to be concentrated into 55 ℃, relative density be 1.10～1.20 thick paste, and get final product.
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| CN101194958B true CN101194958B (en) | 2013-03-27 |
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| ES2667579T3 (en) * | 2012-12-21 | 2018-05-11 | Tasly Pharmaceutical Group Co., Ltd. | Pharmaceutical composition for the treatment of headache and method of preparing it |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1073874A (en) * | 1992-11-14 | 1993-07-07 | 中国人民解放军第二五四医院 | Medicine teken after being mixed with boiling water for invigorating circulation of blood and sobering brain |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1073874A (en) * | 1992-11-14 | 1993-07-07 | 中国人民解放军第二五四医院 | Medicine teken after being mixed with boiling water for invigorating circulation of blood and sobering brain |
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