CN108653434A - A kind of pharmaceutical composition for treating spleen emptiness and wet sputum type Stein-Leventhal syndrome - Google Patents
A kind of pharmaceutical composition for treating spleen emptiness and wet sputum type Stein-Leventhal syndrome Download PDFInfo
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
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- A61K9/00—Medicinal preparations characterised by special physical form
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- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
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- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
Abstract
The invention belongs to spleen emptiness and wet sputum type Stein-Leventhal syndrome treatment technology fields, disclose a kind of pharmaceutical composition for treating spleen emptiness and wet sputum type Stein-Leventhal syndrome.It is made of Radix Astragali 2g, Radix Salviae Miltiorrhizae 3g, Poria cocos 2g, dried orange peel 2g, rhizoma atractylodis 4g, Radix Angelicae Sinensis 3g, Rhizoma Chuanxiong 1g and Radix Glycyrrhizae 1.5g.When making, Radix Astragali 2g, Radix Salviae Miltiorrhizae 3g, Poria cocos 2g, dried orange peel 2g, rhizoma atractylodis 4g, Radix Angelicae Sinensis 3g, Rhizoma Chuanxiong 1g and Radix Glycyrrhizae 1.5g are taken, after cleaning, water is added to be decocted, after decoction, collects the extracting solution decocted out；It then repeats to decoct, is repeatedly purified, after all material purifies, last extracting solution is mixed, ethyl alcohol is then added and is preserved.The present invention is directed to the spleen deficiency damp phlegm of Stein-Leventhal syndrome respectively, irregular menstruation symptom carries out herbal treatment, and the comprehensive symptom to patient is treated, and solves the chief complaint of spleen emptiness and wet sputum type Stein-Leventhal syndrome well.
Description
Technical field
The invention belongs to spleen emptiness and wet sputum type Stein-Leventhal syndrome treatment technology field more particularly to a kind for the treatment of spleen deficiency phlegm
The pharmaceutical composition of wet type Stein-Leventhal syndrome.
Background technology
Stein-Leventhal syndrome is a kind of endocrine for the cause of disease diversity, clinical manifestation polymorphism that Female in child bearing period is common
Metabolic disorder disease, characterized by irregular menstruation or amenorrhoea, hyperandrogenism and ovary change in more capsule samples.It is clinical
Middle spleen emptiness and wet sputum type Stein-Leventhal syndrome is more common, and Symptoms are irregular menstruation, body obesity, amenorrhoea, infertile, simultaneous
See abdominal fullness and distention；Chest tightness and emesis；Complexion is shaken white；Profuse leukorrhea；Pale tongue is fat, and tongue is greasy in vain, deep thready pulse or the spleen deficiency phlegm wet such as sliding of sinking
Symptom.Stein-Leventhal syndrome shows as irregular menstruation, obesity, crinosity, acne the puberty more, in child-bearing period mainly for not
Pregnant and metabolic syndrome is mostly angiocardiopathy complication etc. in climacteric, which annoyings all one's life of patient, and along with
Serious psychiatric problem.Stein-Leventhal syndrome is the hot and difficult issue studied both at home and abroad, and doctor trained in Western medicine mostly uses to the ill at present
Treatment uses clomiphene as a line promoting ovulation drug for infertile；It is controlled using once quick dose of insulin for insulin resistance
It treats；For hyperandrogenism using the male treatment of drop.But current research discovery some patientss are there are clomiphene resistance or not
Sensitivity phenomenon cannot achieve the effect that ovulation induction after patient medication, and Western medicine side effect is big.Between these, the present invention proposes one
Kind treats the pharmaceutical composition of spleen emptiness and wet sputum type Stein-Leventhal syndrome, is adjusted from " Overall View " to patient.
In conclusion problem of the existing technology is：Western medicine is symptomatic treatment, can not be from entirety to patient's
Symptom is intervened comprehensively, and Western medicine toxic side effect is big, becomes pregnant after medication, and the Long-Term Safety of female youngster makes people worried.
Solve the difficulty and meaning of above-mentioned technical problem：
Invention content
In view of the problems of the existing technology, the present invention provides a kind of spleen emptiness and wet sputum type Stein-Leventhal syndromes for the treatment of
Pharmaceutical composition.
The invention is realized in this way a kind of pharmaceutical composition for treating spleen emptiness and wet sputum type Stein-Leventhal syndrome, described
Treat spleen emptiness and wet sputum type Stein-Leventhal syndrome pharmaceutical composition by Radix Astragali 2g, Radix Salviae Miltiorrhizae 3g, Poria cocos 2g, dried orange peel 2g, rhizoma atractylodis 4g,
Radix Angelicae Sinensis 3g, Rhizoma Chuanxiong 1g and Radix Glycyrrhizae 1.5g compositions.
Another object of the present invention is to provide a kind of medicine groups of the treatment spleen emptiness and wet sputum type Stein-Leventhal syndrome
The preparation method of object is closed, the preparation method of the pharmaceutical composition of the treatment spleen emptiness and wet sputum type Stein-Leventhal syndrome includes following
Step：
Step 1, make when, take Radix Astragali 2g, Radix Salviae Miltiorrhizae 3g, Poria cocos 2g, dried orange peel 2g, rhizoma atractylodis 4g, Radix Angelicae Sinensis 3g, Rhizoma Chuanxiong 1g and
Radix Glycyrrhizae 1.5g adds water to be decocted after cleaning, and after decoction, collects the extracting solution decocted out；
Step 2, then repeat decoct, repeatedly purified, all material purification after, by last extracting solution into
Row mixing is then added ethyl alcohol and is preserved.
Further, in the step 1 by extracting solution by filtering accuracy be 0.08 μm of media filtration, to remove extracting solution
Grain size in III is more than 0.08 μm of macromolecular substances, then filter liquor is filtered out in extracting solution by ultra-filtration filters without drug effect
Molecular weight be more than 5000~10000 dalton organic macromolecule material, obtain the high effective components of Chinese medicinal extracting solution of purity；
Ultra-filtration filters, used ultrafiltration membrane select molecular weight cut off for 5000~10000 dalton with processing Chinese medicine difference；It is described super
Filtration filter, can choose the ultrafiltration membrane of different molecular weight cut offs according to the molecular weight of extracted effective components of Chinese medicinal；
Further, effective components of Chinese medicinal is further purified, is concentrated in the step 1：By extracting solution by NF membrane to go
Except the organic solvent of the aqueous solutions of organic solvent in extracting solution IV；The uranium filtration filter, used uranium filter membrane is with organic molten
The difference of organic solvent molecule amount selects molecular weight cut off for the NF membrane of 200~500 dalton in agent aqueous solution.
Further, Radix Astragali entity is broken in the step 1 and spits into 0.5~1 centimetre of big fragment, put into the extraction of stainless steel
In pot, add 95% edible ethanol of 8 times of Radix Astragali dry weight, 78 DEG C are flowed back 1 hour, and alcohol extract is released；Residue remains in pot, then adds
75% edible ethanol of 8 times of weight, 78 DEG C are flowed back 1 hour, and ethanol extract is released；Residue remains in pot, then adds 8 times of amounts
50% edible ethanol, 78 DEG C are flowed back 1 hour, and ethanol extract is released；3 alcohol extracts are merged, it is small that 10 are stood in hopper
When, supernatant liquor is taken out, bottom sediment is discarded；Supernatant recycles ethyl alcohol.
Another object of the present invention is to provide a kind of drugs by the treatment spleen emptiness and wet sputum type Stein-Leventhal syndrome
Tablet prepared by composition.
Another object of the present invention is to provide a kind of drugs by the treatment spleen emptiness and wet sputum type Stein-Leventhal syndrome
Film coated tablet prepared by composition.
Another object of the present invention is to provide a kind of drugs by the treatment spleen emptiness and wet sputum type Stein-Leventhal syndrome
Enteric coated tablet prepared by composition.
Another object of the present invention is to provide a kind of drugs by the treatment spleen emptiness and wet sputum type Stein-Leventhal syndrome
Capsule prepared by composition.
Another object of the present invention is to provide a kind of drugs by the treatment spleen emptiness and wet sputum type Stein-Leventhal syndrome
Oral solution prepared by composition.
Advantages of the present invention and good effect are：The pharmaceutical composition of this treatment spleen emptiness and wet sputum type Stein-Leventhal syndrome
Ingredient is divided into three categories, and is directed to spleen deficiency respectively, damp phlegm and irregular menstruation symptom carry out invigorating spleen to remove dampness, coordinating Chong and Conception Vessels, for more
The common sympton of capsule Ovary Syndrome carries out wholistic therapy to patient, solves spleen emptiness and wet sputum type Stein-Leventhal syndrome well
Chief complaint.This medicine composition components is clear, and compatibility is reasonable, and ingredient is Chinese medicine, based on invigorating the spleen, and with
Dampness removing resolving sputum is finally reached coordinating Chong and Conception Vessels, and the menstruation rhythm and pace of moving things is orderly, and spleen is strong, and water is wet is able to transporting, to metabolic problems such as obesities
It is improved well, solves the problems, such as endocrine metabolism to the greatest extent for patient.
Kidney and spleen invigorating, the resolving sputum dampness removing ingredient of the present invention：Radix Astragali, Radix Salviae Miltiorrhizae, Poria cocos, dried orange peel, rhizoma atractylodis；Adjust menstruation, conditioning
Ingredient is appointed in punching：Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Glycyrrhizae；Radix Astragali, Radix Salviae Miltiorrhizae kidney and spleen invigorating qi-regulating in side, Poria cocos, dried orange peel, rhizoma atractylodis resolving phlegm and drying damp invigorating the spleen,
Radix Angelicae Sinensis, Rhizoma Chuanxiong invigorate blood circulation, coordinating Chong and Conception Vessels, Radix Glycyrrhizae coordinating the drug actions of a prescription.Though it is trouble, assertive evidence that this disease spleen emptiness and wet sputum type PCOS, which is phlegm wet,
Belong to actual situation, mostly by spleen deficiency anemia, then involve kidney yang long, or form for stagnation of liver qi, the transporting of spleen is powerless, wet to be polymerized to phlegm.
Its therapy should be that principle is used cooperatively using the method for logical benefit with " treatinging deficiency with tonification, sthenia syndrome requiring purgation ", and tradeoff then weighs.The present invention is by grey
It is attached lead phlegm ball (《YE Tian shi female section pandect》Change and cuts out.
Description of the drawings
Fig. 1 is the preparation of the pharmaceutical composition for the treatment of spleen emptiness and wet sputum type Stein-Leventhal syndrome provided in an embodiment of the present invention
Method flow diagram.
Specific implementation mode
In order to further understand the content, features and effects of the present invention, the following examples are hereby given, and coordinate attached drawing
1 detailed description are as follows.
The structure of the present invention is explained in detail below in conjunction with the accompanying drawings.
The pharmaceutical composition for the treatment of spleen emptiness and wet sputum type Stein-Leventhal syndrome provided in an embodiment of the present invention is by Radix Astragali 2g, pellet
Join 3g, Poria cocos 2g, dried orange peel 2g, rhizoma atractylodis 4g, Radix Angelicae Sinensis 3g, Rhizoma Chuanxiong 1g and Radix Glycyrrhizae 1.5g compositions.
As shown in Figure 1, the pharmaceutical composition for the treatment of spleen emptiness and wet sputum type Stein-Leventhal syndrome provided in an embodiment of the present invention
Preparation method include the following steps：
S101：When making, Radix Astragali 2g, Radix Salviae Miltiorrhizae 3g, Poria cocos 2g, dried orange peel 2g, rhizoma atractylodis 4g, Radix Angelicae Sinensis 3g, Rhizoma Chuanxiong 1g and sweet are taken
Careless 1.5g adds water to be decocted after cleaning, and after decoction, collects the extracting solution decocted out；
S102：It then repeats to decoct, repeatedly be purified, after all material purifies, last extracting solution is carried out
Mixing is then added ethyl alcohol and is preserved.
In step S101 by extracting solution by filtering accuracy be 0.08 μm of media filtration, to remove in extracting solution III
Grain size is more than 0.08 μm of macromolecular substances, then filter liquor is filtered out the molecular weight without drug effect in extracting solution by ultra-filtration filters
More than the organic macromolecule material of 5000~10000 dalton, the high effective components of Chinese medicinal extracting solution of purity is obtained；Ultra filtration
Filter, used ultrafiltration membrane select molecular weight cut off for 5000~10000 dalton with processing Chinese medicine difference；The ultra filtration
Filter, can choose the ultrafiltration membrane of different molecular weight cut offs according to the molecular weight of extracted effective components of Chinese medicinal；
Effective components of Chinese medicinal is further purified, is concentrated：Extracting solution is removed by NF membrane organic in extracting solution IV
The organic solvent of solvent aqueous solution, to achieve the purpose that purification, concentration；The described uranium filtration filter, used uranium filter membrane is with having
The difference of organic solvent molecule amount selects molecular weight cut off for the NF membrane of 200~500 dalton in solvent aqueous solution.
Radix Astragali entity is broken and spits into 0.5~1 centimetre of big fragment, puts into the extraction pot of stainless steel, adds 8 times of Radix Astragali dry weight
95% edible ethanol, 78 DEG C are flowed back 1 hour, and alcohol extract is released.Residue remains in pot, then adds 75% edible second of 8 times of weight
Alcohol, 78 DEG C are flowed back 1 hour, and ethanol extract is released.Residue remains in pot, then adds 8 times of 50% edible ethanols of amount, 78 DEG C of reflux
1 hour, release ethanol extract.3 alcohol extracts are merged, 10 hours are stood in hopper, supernatant liquor is taken out, discards bottom
Portion's sediment；Supernatant recycles ethyl alcohol.The concentrate gone after ethyl alcohol can be made into raised path between farm fields agent, and plastic is done after also can drying or be spray-dried
The preparations such as capsule.
It is provided in an embodiment of the present invention treatment spleen emptiness and wet sputum type Stein-Leventhal syndrome pharmaceutical composition can be tablet,
Film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral solution, granule, honey pill agent, powder, pellet
Agent, solution etc..
The application principle of the present invention is further described with reference to pharmacological analysis.
Radix Astragali, exterior deficiency spontaneous perspiration：It is chiefly used in the weak caused spontaneous perspiration of physically weak table.Such as exterior Qi instability, and sweating, with Radix Astragali with white
Art, it is windproof control it, long term usage must imitate.Side such as Yupingfeng San；Also it can match Fructus Tritici Levis, radix ephedrae etc..Night sweat due to yin deficiency：It can be with Radix Rehmanniae, wheat
The drugs for nourishing yin such as winter are the same as use.Acute nephritis edema：For the void oedema caused by YANG QI deficiency, and often with tetrandra root, Poria cocos, Rhizoma Atractylodis Macrocephalae etc.
It closes and uses, side such as Tetrandra and Astragalus Decoction.Oedema due to chronic nephritis, spleen kidney deficiency：Often with Radix Codonopsis, Rhizoma Atractylodis Macrocephalae, Poria cocos with use.Yang-energy is weak：With
It invaginates in sore not diabrosis long, has and promote diabrosis and limitation effect.Ulcer not penetrator long, often with pangolin, spina gleditsiae, when
Return, Rhizoma Chuanxiong is the same as use.Sore diabrosis：It does not close up long, there is the effect of promoting granulation and wound healing, often match honeysuckle flower, spina gleditsiae, Chinese violet etc..Fester cleans,
It is equal with Radix Codonopsis, Chinese cassia tree and uses.Syndrome of deficiency of lung qi：With the passing of time, shortness of breath and tired spirit, phlegm harmony is powerlessly brought up cough and asthma in lung.Chang Peiwu asters, coltsfoot
Deng, warm lung Dingchuan, the product of strong lung qi.Spleen gives birth to phlegm, and lung stores up phlegm, so strong lunar with eliminating the phlegm, Radix Astragali tonifying Qi is so outstanding be apt to control the deficiency of vital energy.
The deficiency of vital energy is weak：Lassitude hypodynamia or the sinking of qi of middle-jiao, rectal prolapse, the prolapse of uterus.Air making-up and spleen enlivening, often with the compatibilities such as Radix Codonopsis, Rhizoma Atractylodis Macrocephalae；For
Benefiting qi and raising yang and lift sunken, often shared with Radix Codonopsis, cimicifugae foetidae, radix bupleuri, honey-fried licorice root etc..
Radix Salviae Miltiorrhizae is used for chest impediment and cardialgia, gastral cavity abdomen hypochondriac pain, the accumulation of lump in the abdomen lump in the abdomen, hot numbness pain, dysphoria and insomnia, irregular menstruation, dysmenorrhoea warp
It closes, sore swell and ache curative.
Poria cocos is used for oedema oliguria, phlegm retention anti-dazzle nervous, spleen eating less, loose stool diarrhea, confused and worried, insomnia of palpitating with fear.
Dried orange peel is used for abdominal fullness and distention, and deficiency of food is vomited and diarrhoea, coughing with a lot of sputum.
Rhizoma atractylodis are used for damp retention in middle-jiao, and abdominal fullness and distention, diarrhea, oedema, tinea pedis impotence is preesed, arthralgia pain due to rheumatism, anemofrigid cold, yctalopia,
Eyes dusk is puckery.
Radix Angelicae Sinensis is enriched blood；Promoting blood circulation；Menstruction regulating and pain relieving；Moisturize laxation.The main all cards of the deficiency of blood；Irregular menstruation；Amenorrhea；Dysmenorrhoea；Abdominal mass knot
It is poly-；Uterine bleeding；Asthenia cold abdominalgia；Impotence numbness；Numbness；Intestines are dry and shit is difficult；Weight after dysentery characterized by blood in the stool；Ulcer sores；Injury from falling down.
Rhizoma Chuanxiong, promote breath and open depression, method wind-dryness is wet, promoting blood circulation and stopping pain.It is dizzy to control air-cooled headache rotation, hypochondriac pain abdomen pain, arthritis muscle contraction, warp
It closes, has difficult labour, postpartum stasis block pain, ulcer sores.For irregular menstruation, closed dysmenorrhea, lump in the abdomen abdominal pain, chest side of body shouting pain, tumbling and swelling,
Headache, arthralgia pain due to rheumatism.
Radix Glycyrrhizae is used for the heart qi deficiency, palpitation and severe palpitation, intermittent pulse and deficiency of spleen-QI and stomach-QI, lassitude hypodynamia etc..The former, often and cassia twig
Compatibility, such as Ramuli Cinnamomi and Glycyrrhizae Decoction, zhigancao decoction.The latter is often equal with Radix Codonopsis, Rhizoma Atractylodis Macrocephalae and uses, such as ball in Sijunzi Tang, reason.For
Ulcer sores, abscess of throat etc..It can be applied alone, for oral administration or external application or compatibility application.Ulcer sores are often equal with honeysuckle, Fructus Forsythiae
With playing clearing heat and detoxicating work(, such as Xian fang Huoming Yin altogether.Abscess of throat, often with campanulaceae with use, such as Radix Platycodonis decoction.If in pesticide, food
Poison often matches mung bean or is decocted in water for oral dose with windproof.For asthma and cough.It can be applied alone, it also can compatibility other drugs application.Such as control damp phlegm cough
The erchen tang coughed；Control the Linggan Wuwei Jiangxin Tang of cold productive cough asthma；Control the sangxing decoction of dry stool phlegm cough；It controls heat toxin and causes lung carbuncle cough saliva raw meat
The Radix Platycodonis decoction of smelly phlegm；Control the Gancao Ganjiang soup etc. of cough saliva foam.Another cough due to wind-heat evil, cough due to wind-cold evil, phlegm heat cough also Chang Peiwu
Using.For having a stomachache, abdominal pain and gastrocnemius contraction urgency pain etc.；For reconciling the strong of some drugs.Such as season CHENGQI TANG originally
Product mitigate rheum officinale, the discharge function of saltcake and its stimulation to gastrointestinal tract.In addition, it is all also to commonly use this product reconciliation in many prescriptions
Medicine.Radix Glycyrrhizae has similar adrenocortical hormones fuction.There is inhibiting effect to gastroxia caused by histamine；And have antiacid
It is acted on gastrointestinal smooth muscle spasm is alleviated.Licoflavone, extract of licorice root and enoxolone have apparent antitussive effect；Eliminating the phlegm is made
With also more significant, action intensity is glycyrrhizic acid>Licoflavone>Extract of licorice root.Radix Glycyrrhizae is also anti-inflammatory, anti-allergic effects, can protect
The throat and tunica mucosa tracheae for inflammation of taking care of hair.Extract of licorice root has certain poisonous substances with glycyrrhizic acid the detoxication of similar glucuronic acid.
Radix Glycyrrhizae was commonly used to treat with climacteric and the symptom that comes in Radix Glycyrrhizae because contain glycyrrhizin, was a kind of compound of similar hormone,
It helps to balance the hormone-content in women body.Hypo acid contained by Radix Glycyrrhizae can block the effect of Induced by Carcinogen tumour growth.
For the present invention during clinical observation, 102 patients complete clinical observation, and case is exited without falling off.By this
The spleen emptiness and wet sputum type PCOS patient of three courses for the treatment of of invention drug therapy, reference《New Chinese medicine guideline of clinical investigations》Judgement mark
Standard, treatment case 51, effective 33, effective 16, invalid 2, obvious effective rate 64.7%, total effective rate 96.1%, observation group
Clinical effectiveness is more notable in terms of obvious effective rate and total effective rate；After treatment, patient T, LH, FSH serum endocrine are horizontal
There are decline, pretherapy and post-treatment LH/FSH, T value more to have extremely significant difference (P ＜ 0.01).
The above is only the preferred embodiments of the present invention, and is not intended to limit the present invention in any form,
Every any simple modification made to the above embodiment according to the technical essence of the invention, equivalent variations and modification, belong to
In the range of technical solution of the present invention.
Claims (10)
1. a kind of pharmaceutical composition for treating spleen emptiness and wet sputum type Stein-Leventhal syndrome, which is characterized in that the treatment spleen deficiency phlegm
The pharmaceutical composition of wet type Stein-Leventhal syndrome is by Radix Astragali 2g, Radix Salviae Miltiorrhizae 3g, Poria cocos 2g, dried orange peel 2g, rhizoma atractylodis 4g, Radix Angelicae Sinensis 3g, river
Rhizome of chuanxiong 1g and Radix Glycyrrhizae 1.5g compositions.
2. a kind of preparation method of the pharmaceutical composition for the treatment of spleen emptiness and wet sputum type Stein-Leventhal syndrome as described in claim 1,
It is characterized in that, the preparation method of the pharmaceutical composition of the treatment spleen emptiness and wet sputum type Stein-Leventhal syndrome includes following step
Suddenly：
Step 1 takes Radix Astragali 2g, Radix Salviae Miltiorrhizae 3g, Poria cocos 2g, dried orange peel 2g, rhizoma atractylodis 4g, Radix Angelicae Sinensis 3g, Rhizoma Chuanxiong 1g and Radix Glycyrrhizae when making
1.5g adds water to be decocted after cleaning, and after decoction, collects the extracting solution decocted out；
Step 2 then repeats to decoct, is repeatedly purified, after all material purifies, last extracting solution is mixed
It closes, ethyl alcohol is then added and is preserved.
3. the preparation method of the pharmaceutical composition for the treatment of spleen emptiness and wet sputum type Stein-Leventhal syndrome as claimed in claim 2,
Be characterized in that, in the step 1 by extracting solution by filtering accuracy be 0.08 μm of media filtration, to remove in extracting solution III
Grain size is more than 0.08 μm of macromolecular substances, then filter liquor is filtered out the molecular weight without drug effect in extracting solution by ultra-filtration filters
More than the organic macromolecule material of 5000~10000 dalton, the high effective components of Chinese medicinal extracting solution of purity is obtained；Ultra filtration
Filter, used ultrafiltration membrane select molecular weight cut off for 5000~10000 dalton with processing Chinese medicine difference；The ultra filtration
Filter, can choose the ultrafiltration membrane of different molecular weight cut offs according to the molecular weight of extracted effective components of Chinese medicinal.
4. the preparation method of the pharmaceutical composition for the treatment of spleen emptiness and wet sputum type Stein-Leventhal syndrome as claimed in claim 2,
It is characterized in that, effective components of Chinese medicinal is further purified, concentrated in the step 1：By extracting solution by NF membrane to remove extraction
The organic solvent of aqueous solutions of organic solvent in liquid IV；The uranium filtration filter, used uranium filter membrane are water-soluble with organic solvent
The difference of organic solvent molecule amount selects molecular weight cut off for the NF membrane of 200~500 dalton in liquid.
5. the preparation method of the pharmaceutical composition for the treatment of spleen emptiness and wet sputum type Stein-Leventhal syndrome as claimed in claim 2,
It is characterized in that, Radix Astragali entity is broken in the step 1 and spits into 0.5~1 centimetre of big fragment, puts into the extraction pot of stainless steel, adds
95% edible ethanol of 8 times of Radix Astragali dry weight, 78 DEG C are flowed back 1 hour, and alcohol extract is released；Residue remains in pot, then adds 8 times of weight
75% edible ethanol, 78 DEG C flow back 1 hour, release ethanol extract；Residue remains in pot, then adds 8 times of amounts 50% edible
Ethyl alcohol, 78 DEG C are flowed back 1 hour, and ethanol extract is released；3 alcohol extracts are merged, 10 hours are stood in hopper, in taking-up
Layer clear liquid, discards bottom sediment；Supernatant recycles ethyl alcohol.
6. a kind of tablet prepared by the pharmaceutical composition for treating spleen emptiness and wet sputum type Stein-Leventhal syndrome described in claim 1.
7. a kind of film-coating prepared by the pharmaceutical composition for treating spleen emptiness and wet sputum type Stein-Leventhal syndrome described in claim 1
Tablet.
8. a kind of enteric coating prepared by the pharmaceutical composition for treating spleen emptiness and wet sputum type Stein-Leventhal syndrome described in claim 1
Tablet.
9. a kind of capsule prepared by the pharmaceutical composition for treating spleen emptiness and wet sputum type Stein-Leventhal syndrome described in claim 1
Agent.
10. a kind of pharmaceutical composition for treating spleen emptiness and wet sputum type Stein-Leventhal syndrome described in claim 1 is prepared oral
Liquid.
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Application publication date: 20181016 |