CN105902827A - Traditional Chinese medicine composition for improving immunity of human body and preparation method thereof - Google Patents

Traditional Chinese medicine composition for improving immunity of human body and preparation method thereof Download PDF

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CN105902827A
CN105902827A CN201610310558.9A CN201610310558A CN105902827A CN 105902827 A CN105902827 A CN 105902827A CN 201610310558 A CN201610310558 A CN 201610310558A CN 105902827 A CN105902827 A CN 105902827A
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parts
radix
chinese medicine
medicine composition
preparation
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姜俊
王震
赵红星
王勇
李燕
王全江
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Zhumadian academy of agricultural sciences
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
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    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

Abstract

The invention discloses a traditional Chinese medicine composition for improving immunity of a human body and a preparation method thereof. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 15 to 20 parts of radix astragali, 15 to 20 parts of toadstool, 15 to 20 parts of herba dendrobii, 12 to 15 parts of lucid ganoderma, 12 to 15 parts of bark of cortex eucommiae, 12 to 15 parts of glossy privet fruit, 12 to 15 parts of radix cynanchi bungei, 8 to 10 parts of tortoiseshell, 8 to 10 parts of herba ecliptae, 8 to 10 parts of poria cocos, 5 to 7 parts of root of Chinese thorowax, 5 to 7 parts of radix scrophulariae, 5 to 7 parts of honeysuckle flower, 5 to 7 parts of American ginseng, 3 to 5 parts of radix aucklandiae, 3 to 5 parts of rhodiola rosea, 3 to 5 parts of radix ophiopogonis, 1 to 3 parts of licorice root, and 1 to 3 parts of radix tetrastigme. The preparation method has the advantages that the traditional Chinese medicine decoction technique is assisted by the centrifuging technique and microwave-ultrasonic comprehensive extraction technique, and water and ethanol are used as main extracting agents, so that the effective ingredients of traditional Chinese medicinal materials are extracted; the extraction type is simple, and the efficiency is high.

Description

Improve Chinese medicine composition of body immunity and preparation method thereof
Technical field
The present invention relates to a kind of Chinese medicine composition and preparation method thereof, especially relate to a kind of raising in body immunity Drug composition and preparation method thereof.
Background technology
Immunity is the defense mechanism of human body self, is human bioequivalence and the physiological reaction pushed aside or excluded persons of different views.The fall of immunity Low is one of the root of Occurrence and development of disease.
Adrenocortical insufficiency commonly encountered diseases is because of acate pneumonic tuberculosis or autoimmune adrenalitis；Rare disease Because including that deep fungal infection, immunodeficiency, virus infection, malignant tumor, adrenal gland be the most hemorrhage, excision adrenal gland, Leukodystrophy and POEMS disease etc..Secondary hypocortisolism disease, is most commonly in prolonged application excusing from death reason agent The glucocorticoid of amount, it is possible to be secondary to Hypothalamus-pituitary disease, such as sellar tumour, autoimmune hypophysitis wound, operation Excision, postpartum hemorrhage cause hypophysis large area infarction downright bad, i.e. Sheehan syndrome etc..
Postoperative body function is deficient includes that Patients Treated by Radiotherapy immunity function after chemotherapy (cellular immunization and humoral immunization) damages, and suffers from Lymphocyte nuclear DNA damage after person's radiotherapy, chemotherapy, is inevitably infringement in medical treatment, because Chinese medicine can overall be adjusted Joint, fundamentally adjusts and makes lymhocyte transformation rate still keep normal level, thus substantially alleviate caused by radiotherapy and chemotherapy immunologic function The degree of damage.But the medicament composing prescription at present with raising immunity is less.
The patent of invention of Application No. 201410115377.1 provides a kind of compositions improving immunity, by with prescribe medicine Thing is prepared from: Radix Codonopsis 8g, hoary head 6g, Carapax et Plastrum Testudinis 8g, Herba Ecliptae 8g, Ganoderma 8g, Pericarpium Arecae 7g, Poria 7g, Radix Bupleuri 6g, Radix Scrophulariae 6g, Flos Lonicerae 6g, Cortex Eucommiae 8g, Herba Dendrobii 8g, Radix Panacis Quinquefolii 6g, Radix Aucklandiae 6g, Radix Rhodiolae 7g, 6g Radix Ophiopogonis, Radix Astragali 6g, Radix Glycyrrhizae 3g, have Significantly improve the effect of immunity of organisms.The patent of invention of Application No. 201410319895.5 discloses a kind of body resistance-strengthening Zhenqi The preparation method of preparation, by first extracting Fructus Ligustri Lucidi and the Radix Astragali, then uses supercentrifugal process to concentrating having in clear paste Effect composition is purified, and not only extraction process is simple, workable, and extraction efficiency is high, and the effective ingredient extracted is pure Spend the most raised to protection bone marrow adrenal cortex and the function of liver, but also can further improve the immunity of body.But Being that the prescription in existing scheme is the most single, function is the most comprehensive.
Summary of the invention
In view of this, it is an object of the invention to for the deficiencies in the prior art, it is provided that a kind of improve in body immunity Drug composition and preparation method thereof, solves body immunity damage problem or has reached the effect of General Promotion immunity of organisms Really.
For reaching above-mentioned purpose, the present invention by the following technical solutions:
A kind of Chinese medicine composition improving body immunity, is made up of the raw material of following weight portion: the Radix Astragali 15～20 parts, sheep Tripe bacterium 15～20 parts, Herba Dendrobii 15～20 parts, Ganoderma 12～15 parts, the Cortex Eucommiae 12～15 parts, Fructus Ligustri Lucidi 12～15 parts, Radix Cynanchi Auriculati 12～ 15 parts, Carapax et Plastrum Testudinis 8～10 parts, Herba Ecliptae 8～10 parts, Poria 8～10 parts, Radix Bupleuri 5～7 parts, Radix Scrophulariae 5～7 parts, Flos Lonicerae 5～7 Part, Radix Panacis Quinquefolii 5～7 parts, the Radix Aucklandiae 3～5 parts, Radix Rhodiolae 3～5 parts, Radix Ophiopogonis 3～5 parts, Radix Glycyrrhizae 1～3 parts and Radix Apioris Fortunei (Radix Lespedezae Buergeri) 1～3 parts.
Preferably, be made up of the raw material of following weight portion: the Radix Astragali 16 parts, Morchella esculenta (L.) Pers 18 parts, Herba Dendrobii 16 parts, Ganoderma 12 parts, The Cortex Eucommiae 12 parts, Fructus Ligustri Lucidi 12 parts, Radix Cynanchi Auriculati 13 parts, Carapax et Plastrum Testudinis 8 parts, Herba Ecliptae 8 parts, 9 parts of Poria, Radix Bupleuri 6 parts, Radix Scrophulariae 6 parts, gold silver Spend 6 parts, Radix Panacis Quinquefolii 6 parts, the Radix Aucklandiae 4 parts, Radix Rhodiolae 4 parts, Radix Ophiopogonis 4 parts, 3 parts of Radix Glycyrrhizae and Radix Apioris Fortunei (Radix Lespedezae Buergeri) 1 part.
Improve the preparation method of the Chinese medicine composition of body immunity, including following preparation process:
1) weigh the Radix Astragali, Morchella esculenta (L.) Pers, Herba Dendrobii, Ganoderma, the Cortex Eucommiae, Fructus Ligustri Lucidi, Radix Cynanchi Auriculati, Carapax et Plastrum Testudinis, Herba Ecliptae, Poria, Radix Bupleuri, Radix Scrophulariae, Flos Lonicerae, Radix Panacis Quinquefolii, the Radix Aucklandiae, Radix Rhodiolae and Radix Ophiopogonis, clean, pulverize, add 1.0～2.0 times of weight parts waters, 30～50 DEG C soak 1.0～1.5 hours；
2) by step 1) the raw material supersound extraction soaked, filters, collects extracting solution and filtering residue respectively；
3) by step 2) gained filtering residue regulation pH value be 6.5～7.5, add ethanol microwave extraction, collect extracting solution；
4) by step 2) and step 3) gained extracting solution merges, concentrates, is dried；
5) weigh Radix Glycyrrhizae and Radix Apioris Fortunei (Radix Lespedezae Buergeri), clean, superfine powder to 10～20 μm；
6) by step 5) products therefrom adds 1.5～2.0 times of weight parts waters, soaks 15～20 minutes, 25～30 DEG C, 1500～ 2000 revs/min, centrifugal 5～10 minutes；
7) step 6 is collected) the centrifugal gained supernatant, it is concentrated into water content 35～50wt%；
8) by step 4) products therefrom joins step 7) in products therefrom, obtain mixing ointment, add 5～10wt% auxiliary Material, mix homogeneously, drying agent.
Preferably, described step 2) in the concrete technology condition of supersound extraction be: 80～85 DEG C, 1200～1500 watts, carry Take time 30～45 minutes.
Preferably, described step 3) in the process conditions of microwave extraction be: 65～75 DEG C, 250～300 watts, extraction time 15～20 minutes, solid-liquid ratio was 1 gram: 25～30 milliliters.
Preferably, described step 4) in be dried be 45～50 DEG C, vacuum drying 2～3 hours.
Preferably, described step 8) in adjuvant be the one in sucrose, dextrin, mannitol and poly-PEG4000 or one with On combination in any.
Preferably, described step 8) in preparation include decoction, granule, tablet, capsule, powder, unguentum and pill.
In each material component of the present invention, pharmacology and the drug effect of every component raw material be:
The Radix Astragali, enhancing human body immunity function, protect the liver, diuresis, defying age, anti-stress, blood pressure lowering and wide antibacterial action. Jishengshenqiwan albuminuria can be eliminated, strengthen myocardial contraction, regulate blood sugar content.The Radix Astragali can not only coronary artery dilator, change Kind blood supply of cardiac muscle, improves immunologic function, and can the process of delaying cell aging.Radix Astragali instant, can decoct soup, soft extracts, Infusing drugs in wine, enters dish etc..
Morchella esculenta (L.) Pers, useful the intestines and stomach, the effect such as aid digestion, phlegm-eliminiating and qi-regulating, kidney invigorating and YANG supporting, supplementing the brain are refreshed oneself, the most also have strong Body is healthy and strong, preventing cold, strengthens effect of body immunity.Morchella esculenta (L.) Pers is containing the polysaccharide of suppression tumor, antibacterial, the activity of antiviral Composition, has all multiactions such as enhancing human body immunity power, resisting fatigue, antiviral, suppression tumor.Japanese Scientists finds Morchella esculenta (L.) Pers Containing tyrosinase inhibitor in extracting solution, can effectively suppress the formation of lipofuscin.Selenium abundant contained by Morchella esculenta (L.) Pers is people The constituent of body erythrocyte glutathione peroxidase, can transport a large amount of oxygen molecule to suppress malignant tumor, make cancerous cell lose Live；Another aspect can strengthen the antioxidation of vitamin E.The antioxidation of selenium can change direction of carcinogenic generation, and passes through In conjunction with and detoxify, thus carcinogenic danger is reduced or eliminated.
Herba Dendrobii, has another name called lofty or bottomless palpus.Li Shizhen (1518-1593 A.D.) evaluates Herba Dendrobii in Compendium of Material Medica, and " reinforcing YIN-essence benefit is smart, thick the intestines and stomach, in benefit never Foot, flat gastric qi, long muscle, Fructus Alpiniae Oxyphyllae, except frightened, made light of one's life by commiting suicide and is prolonged life ".
Ganoderma, Shennong's Herbal: " Ganoderma lucidum (Leyss. Ex Fr.) Karst., bitter in the mouth is put down.Master ties in the heart, the benefit motive, and invigorating middle warmer increases intelligence, do not forgets.Food for a long time, Making light of one's life by commiting suicide not old, prolong life angle.One Ganoderma lucisum.
The Cortex Eucommiae, has rubbish in purged body, strengthens human body cell substance metabolism, prevents muscle skeleton aging, balanced human Blood pressure, decomposer inner cholesterol, reduction body fat, recovery blood vessel elasticity, diuresis heat clearing away, broad-spectrum antiseptic, stimulating central nervous system, Improve leukocyte pharmacological action.
Fructus Ligustri Lucidi, has nourishing the liver and kidney, the function of improving eyesight black hair.The feature of Fructus Ligustri Lucidi is that the property of medicine is more gentle, and effect is slow Slowly, taking the beginning for a long time can take effect.Optic neuritis, leukopenia, chronic hepatitis, hyperlipidemia, coronary disease it is additionally operable on modern clinic Disease, hypertension, Chidren Poisoning auditory dysesthesia, neurasthenia, facial paralysis, alopecia etc..Fructus Ligustri Lucidi medical value is high, according to " Bencao Jingshu " record: " Fructus Ligustri Lucidi, abnormal smells from the patient is the most cloudy, and just entering kidney heat extraction benefit essence wants product, and kidney must be mended, then the five internal organs are from peace, and spirit is certainly Foot, all kinds of diseases and ailments are gone and body fertilizer is good for.”
Radix Cynanchi Auriculati, nourishing the liver and kidney, strengthening body, nourish blood and enrich blood, crow palpus hair color, restrain vital essence, promoting tissue regeneration and ulcer healing, intestine moistening is led to Just.Cure mainly prolonged illness weak, chronic migratory arthralgia, soreness of the waist and knees, anemia, enterorrhagia, early whitening of beard and hair, neurasthenia, deficiency of YIN chronic malaria, ulcer Do not close up for a long time, old people constipation.Meridian distribution of property and flavor " Shandong Chinese medicine ": " bitter but sweet flavor is puckery, slightly warm in nature, nontoxic." enter liver, kidney two warp.
Carapax et Plastrum Testudinis, nourishing YIN for suppressing the hyperactive YANG, kidney tonifying bone strengthening, reinforcing the heart of nourishing blood, Gu through only collapsing.Cure mainly for deficiency of YIN hectic fever, hectic fever due to YIN-deficiency night sweat, head Dizzy dizzy, stirring-up of pathogenic wind in the interior resulting from deficiency, muscles and bones flaccidity is soft, has a guilty conscience forgetful, and metrorrhagia is through many.
Herba Ecliptae, Compendium of Material Medica points out Herba Ecliptae " crow beard and hair, kidney tonifying is cloudy "." book on Chinese herbal medicine is stated " is thought, Herba Ecliptae " treats hematuria And suffer from a deficiency of the kidney become stranguria caused by overstrain ".Clinically, Herba Ecliptae often and the same use of Fructus Ligustri Lucidi, Herba Ecliptae and Fructus Ligustri Lucidi protect the liver, detoxify, drop The diseases such as the effect of low transaminase, can treat the hepatic and renal YIN deficiency, has a sleepless night vexed, and tinnitus is dizzy, soreness of the waist and knees.
Poria, promoting diuresis to eliminate damp pathogen, spleen invigorating, mind calming.Cure mainly for edema oliguria, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, loose stool has loose bowels, Irritability, palpitation with fear insomnia.
Radix Bupleuri, reconciling superficies and interior, dispersing the stagnated live-QI to relieve the stagnation of QI, ascending up spleen-Qi and Yang, preventing the attack (or recurrence) of malaria of bringing down a fever.Cure mainly for cold, fever, alternate attack of chill and fever, breast Side of body distending pain, menoxenia, uterine prolapse, proctoptosis.
Radix Scrophulariae, clearing away heat and cooling blood；Nourishing YIN to lower pathogenic fire；Detoxicating and resolving stagnation of pathogens.Main warm febrile disease and nutrient blood；Fever of the body；Excessive thirst；Crimson tongue；Send out speckle； Hectic fever due to YIN-deficiency chronic cough；Fidgets due to deficiency not awake；Constipation is hindered in Tianjin；Mesh is puckery dim-sighted；Throat larynx swells and ache；Scrofula sucutaneous nodule；Skin sore.
Flos Lonicerae is cold in nature, sweet in the mouth, enters lung, the heart, stomach warp, has heat-clearing and toxic substances removing, antiinflammatory, effect of qi-restoratives treatment wind, cures mainly swollen Disease, epidemic febrile disease is completely descended to generate heat, the disease such as pyretic toxicity carbuncle and ulcer and tumor.It makees thirsty, hyperhidrosis unhappiness, enteritis, bacterium for dizzy dizzy, xerostomia Dysentery, measles, pneumonia, encephalitis b, epidemic encephalitis, acute mastitis, septicemia, appendicitis, skin infection, carbuncle furuncle, erysipelas, the parotid gland The diseases such as inflammation, suppurative tonsillitis all have certain curative effect.
Radix Panacis Quinquefolii has YIN nourishing and QI supplementing, the mind calming and mentality promoting and clearing away heat and promoting production of body fluid, the double effects that pathogenic fire reducing is relieved summer heat.Archaism cloud: " the West Join cool in nature and mend, all Radix Ginsengs to be used and all can be with it by the temperature person of Radix Ginseng ".Therefore mend and the driest be the special feature of Radix Panacis Quinquefolii. Function cures mainly: strengthening cardiac muscle and the mobility of enhancing heart；Strong nervus centralis, stable body and mind also sets up, has calmness And antialcoholism action, hypermnesis ability, Alzheimer there is is remarkable efficacy；Blood pressure there is is Accommodation, makes temporary or hold Property blood pressure drops for a long time. suppression arteriosclerosis also promotes Growth of red blood cells, increases the deal of hematochrome；The secretion of islets of langerhans can be regulated, Therefore powerful to diabetes；Liver is had the secretion of regulation toxin, the effect enhanced metabolism；Can physical strength reinforcing to fortune Tool is mobilized greatly to benefit；Anticancer grows, and increases immunologic function；Encourage digestion, help chronic gastropathy and the intestines and stomach are weak Effect.
The Radix Aucklandiae, its effect: circulation of qi promoting, pain relieving, spleen invigorating, help digestion.Cure mainly: promoting the circulation of QI to relieve pain；Intestinal stasis relieving in tune.Main born of the same parents coerce distension foot； Abdominal distention；Tell and have loose bowels；Weight after dysentery.Weigh after breast gastral cavity distending pain, dysentery, food stagnation does not disappears, anorexia；Middle gas does not saves； Sudden deafness；Snake bite and insect sting；Toothache.Function cures mainly: the distension and fullness in the abdomen of stagnation of QI in spleen and stomach or pain, belch, nausea and vomiting；In turbid damp The abdominal distention uncomfortable in chest of resistance, indigestion and loss of appetite loose stool；Phlegm-damp stops up the cough and asthma of lung；Pathogen, wards off poison epidemic disease temperature ghost, Qiang Zhi, and main pouring is revealed, taken not dream for a long time Awake horrible nightmare；Sterilization, kill ghost essence thing, pyrexial malaria diseases due to noxious agents produced by various parasites, the bad QI-insufficiency of gas, the coldest in flesh, the essence of priming.
Radix Rhodiolae, nature and flavor: cold, sweet, puckery.Gui Jing: lung meridian.Function cures mainly: have QI invigorating lung heat clearing, Fructus Alpiniae Oxyphyllae to nourish heart, hemostasis with astringents, Effect of dissipating blood stasis for subsidence of swelling.Cure mainly deficiency of vital energy and physically weak, after being ill fear of cold, shortness of breath and fatigue, cough due to lung-heat, spitting of blood, leucorrhea diarrhoea, traumatic injury Deng.
Radix Ophiopogonis, Radix Ophiopogonis is classified as the top grade of nourishing YIN and moistening the lung by Shennong's Herbal, says its " clothes are made light of one's life by commiting suicide for a long time, the most not hungry "." this Grass lease making " claim that " hardship sweet, micro-, is slightly cold Radix Ophiopogonis.Lung moistening clears away heart-fire, purge heat and promote the production of body fluid, the preventing or arresting vomiting that reduces phlegm, control row water of coughing "." ginseng west in medical science inner feelings Record " say it: " stomach can be entered with nourishing the stomach liquid, stimulating appetite, more can enter spleen helping spleen to dissipate and be skillful in lung, Dingchuan relieving coughing." traditional Chinese medical science thinks, wheat Winter sweet in the mouth, micro-hardship, cold nature, return stomach, lung, heart channel, have nourishing YIN and moistening the lung, reinforcing stomach reg fluid, the effect of the relieving restlessness that clears away heart-fire, do for the dryness of the lung Cough, the disease such as deficiency of YIN consumptive disease is coughed, sore throat pharyngalgia, Tianjin wound are thirsty, interior-heat is quenched one's thirst, vexed insomnia, dryness of the intestine constipation.
Radix Glycyrrhizae: effect is used for insufficiency of heart-QI, severe palpitation, irregularly intermittent and regularly intermittent pulse, and deficiency of spleen-QI and stomach-QI, fatigue and weakness etc..The former, often with Ramulus Cinnamomi compatibility, such as Ramuli Cinnamomi and Glycyrrhizae Decoction, zhigancao decoction.The latter, is often equal to use with Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, such as ball etc. in decoction of four noble drugs, reason. For ulcer sores, laryngopharynx swelling and pain etc..Can be alone, for oral administration or external application, or compatibility application.Ulcer sores, normal and Flos Lonicerae, Fructus Forsythiae Equivalent use, plays the merit of heat-clearing and toxic substances removing, altogether such as Xian fang Huoming Yin.Laryngopharynx swelling and pain, the normal and same use of Radix Platycodonis, such as Radix Platycodonis decoction.If pesticide, food Thing is poisoned, and often joins Semen phaseoli radiati or is decocted in water for oral dose with Radix Saposhnikoviae.For asthma and cough.Can be alone, also can the application of compatibility other drug.As wet in controlled The ERCHEN TANG that productive cough is coughed；Control the Linggan Wuwei Jiangxin Tang of cold-phlegm cough with asthma；Control the sangxing decoction of dry stool phlegm cough；Control pyretic toxicity and cause lung abscess and cough The Radix Platycodonis decoction of the smelly purulent sputum of vomitus smelt as decayed fish；Control the Gancao Ganjiang soup etc. of cough and spit saliva foam.Another cough due to pathogenic wind-heat, cough due to wind and cold, phlegm heat cough are the most normal Compatibility is applied.
Radix Apioris Fortunei (Radix Lespedezae Buergeri): heat-clearing and toxic substances removing, promoting blood circulation by removing wind.
Technical scheme carries out Comprehensive Treatment with kinds of traditional Chinese medicines compatibility, uses tcm prescription " monarch, minister, help, make " The medication of the theory side of sending.
Monarch drug: Radix Astragali enhancing human body immunity function, protect the liver, diuresis, defying age, anti-stress, blood pressure lowering and wide antibacterial Effect；The effects such as the useful the intestines and stomach of Morchella esculenta (L.) Pers, aid digestion, phlegm-eliminiating and qi-regulating, kidney invigorating and YANG supporting, supplementing the brain are refreshed oneself, the most also have and keep fit to be good for Body, preventing cold, strengthen effect of body immunity；Herba Dendrobii " reinforcing YIN-essence benefit essence, thick the intestines and stomach, never sufficient in benefit, flat gastric qi, longue Meat, Fructus Alpiniae Oxyphyllae, except frightened, made light of one's life by commiting suicide and is prolonged life "；The Ganoderma benefit motive, invigorating middle warmer, increase intelligence, do not forget.Food for a long time, makes light of one's life by commiting suicide not old, life lengthening.Four medicines Enhancing human body immunity function altogether, and have his own strong points.
Ministerial drug: Radix Cynanchi Auriculati nourishing the liver and kidney, strengthening body, nourishes blood and enriches blood；Carapax et Plastrum Testudinis nourishing YIN for suppressing the hyperactive YANG, kidney tonifying bone strengthening, reinforcing the heart of nourishing blood, Gu through only collapsing；Herba Ecliptae is treated hematuria and suffers from a deficiency of the kidney and become stranguria caused by overstrain, Poria promoting diuresis to eliminate damp pathogen, spleen invigorating, mind calming；Radix Bupleuri reconciling superficies and interior, soothing the liver Resolving depression, ascending up spleen-Qi and Yang, preventing the attack (or recurrence) of malaria of bringing down a fever；Radix Scrophulariae clearing away heat and cooling blood；Nourishing YIN to lower pathogenic fire；Detoxicating and resolving stagnation of pathogens；Flos Lonicerae is cold in nature, sweet in the mouth, enter lung, The heart, stomach warp, have heat-clearing and toxic substances removing, antiinflammatory, effect of qi-restoratives treatment wind；Radix Panacis Quinquefolii YIN nourishing and QI supplementing, the mind calming and mentality promoting and clearing away heat and promoting production of body fluid, fall The double effects that fire is relieved summer heat；Radix Aucklandiae circulation of qi promoting, pain relieving, spleen invigorating, help digestion.Promoting the circulation of QI to relieve pain；Intestinal stasis relieving in tune, vital base and primordial QI consolidating.This 8 taste medicine is altogether Same-action dispersing the stagnated live-QI to relieve the stagnation of QI, YIN nourishing and QI supplementing, further enhancing the beneficial motive of monarch drug, effect of invigorating middle warmer.
Adjuvant drug: Radix Rhodiolae nature and flavor, cold, sweet, puckery, and hardship sweet, micro-Radix Ophiopogonis, it is slightly cold.Lung moistening clears away heart-fire, purge heat and promote the production of body fluid, only reduce phlegm Vomit, control row water of coughing.Jointly act on monarch drug and ministerial drug, the effect further enhancing this formula body-building immunity, acting as expectorant, make Monarch drug and ministerial drug effect are the most harmonious smooth and easy.
Radix Glycyrrhizae and Radix Apioris Fortunei (Radix Lespedezae Buergeri) are for making medicine, and property is flat, sweet in the mouth, relieving spasm to stop pain, heat-clearing and toxic substances removing, promoting blood circulation by removing wind, coordinating the actions of various ingredients in a prescription.The monarch and his subjects Assistant makes synergism, coordinates each other.
The invention has the beneficial effects as follows:
The present invention improves the Chinese medicine composition of immunity and carries out Comprehensive Treatment with kinds of traditional Chinese medicines compatibility, uses tcm prescription " monarch, minister, help, make " the theory side of sending medication.The drug matching of multi-flavor position is proper, learns from other's strong points to offset one's weaknesses, and coordinates each other, have clearing away heat-damp and promoting diuresis, Effect such as blood circulation promoting and blood stasis dispelling, strengthening the body resistance, it is possible to fundamentally regulate the function of human immune system, promote function of immune system Recover and strengthen.It is applicable to adrenocortical insufficiency commonly encountered diseases because of acate pneumonic tuberculosis or autoimmune adrenal Inflammation, or postoperative body function is deficient includes that Patients Treated by Radiotherapy immunity function after chemotherapy (cellular immunization and humoral immunization) is all damaged Wound, lymphocyte nuclear DNA damage after Patients Treated by Radiotherapy, chemotherapy, there is instant effect, cure rate is high, relapse rate is low, treating both the principal and secondary aspects of a disease, system The standby feature such as easy, with low cost.
The present invention improves the preparation work method of the Chinese medicine composition of immunity and decocts auxiliary centrifugation technique, micro-with Chinese medicine Ripple-ultrasonic comprehensive extractive technique, is main extractant with water and ethanol, extracts Effective Component of Chinese Medicine, and extracting mode is the most efficient.
The all raw materials chosen of this Chinese herbal medicine are nontoxic pure natural Chinese herbal medicine, therefore use the high immunity of the present invention The Traditional Chinese medicine composition formula of power does not have toxic and side effects, in conjunction with existing theory and technology, clinical experience and Chinese medicine extraction technology, can reach Effective ingredient extracts reliable, and technical process is produced on a large scale, and is suitable to popularization and application.
Detailed description of the invention
Illustrate present disclosure with detailed description of the invention below, do not limit the claim protection of the present invention with this Scope.
Embodiment 1
A kind of Chinese medicine composition improving body immunity, is made up of the raw material of following weight portion: the Radix Astragali 16 parts, Morchella esculenta (L.) Pers 18 parts, Herba Dendrobii 16 parts, Ganoderma 12 parts, the Cortex Eucommiae 12 parts, Fructus Ligustri Lucidi 12 parts, Radix Cynanchi Auriculati 13 parts, Carapax et Plastrum Testudinis 8 parts, Herba Ecliptae 8 parts, Poria 9 Part, Radix Bupleuri 6 parts, Radix Scrophulariae 6 parts, Flos Lonicerae 6 parts, Radix Panacis Quinquefolii 6 parts, the Radix Aucklandiae 4 parts, Radix Rhodiolae 4 parts, Radix Ophiopogonis 4 parts, 3 parts of Radix Glycyrrhizae and three Blue or green 1 part of leaf.
The preparation method of the Chinese medicine composition of this raising body immunity, including following preparation process:
1) weigh the Radix Astragali, Morchella esculenta (L.) Pers, Herba Dendrobii, Ganoderma, the Cortex Eucommiae, Fructus Ligustri Lucidi, Radix Cynanchi Auriculati, Carapax et Plastrum Testudinis, Herba Ecliptae, Poria, Radix Bupleuri, Radix Scrophulariae, Flos Lonicerae, Radix Panacis Quinquefolii, the Radix Aucklandiae, Radix Rhodiolae and Radix Ophiopogonis, clean, pulverize, add 1.0 times of weight parts waters, be placed in airtight appearance In device, pressurization, 30 DEG C are soaked 1.0 hours；
2) by step 1) the raw material supersound extraction soaked, filter, collect extracting solution and filtering residue respectively, supersound extraction concrete Process conditions are: 80 DEG C, 1200 watts, 30 minutes extraction times；
3) by step 2) gained filtering residue regulation pH value be 6.5, add ethanol microwave extraction, collect extracting solution, microwave extraction Process conditions be: 65 DEG C, 250 watts, 15 minutes extraction times, solid-liquid ratio 1 gram: 25 milliliters；
4) by step 2) and step 3) gained extracting solution merges, concentrates, 45 DEG C of vacuum dryings 2 hours；
5) weighing Radix Glycyrrhizae and Radix Apioris Fortunei (Radix Lespedezae Buergeri), clean, superfine powder is to 10 μm；
6) by step 5) products therefrom adds 1.5 times of weight parts waters, soaks 15 minutes, and 25 DEG C, 1500 revs/min, centrifugal 5 points Clock；
7) step 6 is collected) the centrifugal gained supernatant, it is concentrated into water content 35wt%；
8) by step 4) products therefrom joins step 7) in products therefrom, mix ointment, add the sucrose of 6wt%, mixed Close uniformly, be dried and make granule.
Embodiment 2
A kind of Chinese medicine composition improving body immunity, is made up of the raw material of following weight portion: the Radix Astragali 15 parts, Morchella esculenta (L.) Pers 15 parts, Herba Dendrobii 15 parts, Ganoderma 12 parts, the Cortex Eucommiae 12 parts, Fructus Ligustri Lucidi 12 parts, Radix Cynanchi Auriculati 12 parts, Carapax et Plastrum Testudinis 8 parts, Herba Ecliptae 8 parts, Poria 8 Part, Radix Bupleuri 5 parts, Radix Scrophulariae 5 parts, Flos Lonicerae 5 parts, Radix Panacis Quinquefolii 5 parts, the Radix Aucklandiae 3 parts, Radix Rhodiolae 3 parts, Radix Ophiopogonis 3 parts, 1 part of Radix Glycyrrhizae and three Blue or green 1 part of leaf.
The preparation method of the Chinese medicine composition of this raising body immunity, including following preparation process:
1) weigh the Radix Astragali, Morchella esculenta (L.) Pers, Herba Dendrobii, Ganoderma, the Cortex Eucommiae, Fructus Ligustri Lucidi, Radix Cynanchi Auriculati, Carapax et Plastrum Testudinis, Herba Ecliptae, Poria, Radix Bupleuri, Radix Scrophulariae, Flos Lonicerae, Radix Panacis Quinquefolii, the Radix Aucklandiae, Radix Rhodiolae and Radix Ophiopogonis, cleaning, pulverize, add 1.2 times of weight parts waters, 32 DEG C are soaked 1.1 Hour；
2) by step 1) the raw material supersound extraction soaked, process with 30～45 μm membrane filtrations, collect extracting solution and filter respectively Slag, the concrete technology condition of supersound extraction is: 81 DEG C, 1250 watts, 31 minutes extraction times；
3) by step 2) gained filtering residue regulation pH value be 6.7, add ethanol microwave extraction, collect extracting solution, microwave extraction Process conditions be: 67 DEG C, 260 watts, 16 minutes extraction times, solid-liquid ratio is 1 gram: 26 milliliters；
4) by step 2) and step 3) gained extracting solution merges, concentrates, 46 DEG C of vacuum dryings 2.2 hours；
5) weighing Radix Glycyrrhizae and Radix Apioris Fortunei (Radix Lespedezae Buergeri), clean, superfine powder is to 12 μm；
6) by step 5) products therefrom adds 1.6 times of weight parts waters, soaks 16 minutes, and 26 DEG C, 2000 revs/min, centrifugal 6 points Clock；
7) step 6 is collected) it is centrifuged the gained supernatant, is concentrated into water content 38wt%；
8) by step 4) products therefrom joins step 7) in products therefrom, obtain mixing ointment, add the mannitol of 8wt% Mix homogeneously, be dried make decoction.
Embodiment 3
A kind of Chinese medicine composition improving body immunity, is made up of the raw material of following weight portion: the Radix Astragali 16 parts, Morchella esculenta (L.) Pers 18 parts, Herba Dendrobii 16 parts, Ganoderma 12 parts, the Cortex Eucommiae 12 parts, Fructus Ligustri Lucidi 12 parts, Radix Cynanchi Auriculati 13 parts, Carapax et Plastrum Testudinis 8 parts, Herba Ecliptae 8 parts, Poria 9 Part, Radix Bupleuri 6 parts, Radix Scrophulariae 6 parts, Flos Lonicerae 6 parts, Radix Panacis Quinquefolii 6 parts, the Radix Aucklandiae 4 parts, Radix Rhodiolae 4 parts, Radix Ophiopogonis 4 parts, 3 parts of Radix Glycyrrhizae and three Blue or green 1 part of leaf.
The preparation method of the Chinese medicine composition of this raising body immunity, including following preparation process:
1) weigh the Radix Astragali, Morchella esculenta (L.) Pers, Herba Dendrobii, Ganoderma, the Cortex Eucommiae, Fructus Ligustri Lucidi, Radix Cynanchi Auriculati, Carapax et Plastrum Testudinis, Herba Ecliptae, Poria, Radix Bupleuri, Radix Scrophulariae, Flos Lonicerae, Radix Panacis Quinquefolii, the Radix Aucklandiae, Radix Rhodiolae and Radix Ophiopogonis, cleaning, pulverize, add 1.4 times of weight parts waters, 34 DEG C are soaked 1.2 Hour；
2) by step 1) the raw material supersound extraction soaked, filter, collect extracting solution and filtering residue respectively, supersound extraction concrete Process conditions are: 82 DEG C, 1350 watts, 35 minutes extraction times；
3) by step 2) gained filtering residue regulation pH value be 6.9, add ethanol microwave extraction, collect extracting solution, microwave extraction Process conditions be: 69 DEG C, 270 watts, 17 minutes extraction times, solid-liquid ratio is 1 gram: 27 milliliters；
4) by step 2) and step 3) gained extracting solution merges, concentrates, 47 DEG C of vacuum dryings 2.4 hours；
5) weighing Radix Glycyrrhizae and Radix Apioris Fortunei (Radix Lespedezae Buergeri), clean, superfine powder is to 14 μm；
6) by step 5) products therefrom adds 1.7 times of weight parts waters, soaks 17 minutes, and 27 DEG C, 1750 revs/min, centrifugal 7 points Clock；
7) step 6 is collected) it is centrifuged the gained supernatant, is concentrated into water content 40wt%；
8) by step 4) products therefrom joins step 7) in products therefrom, obtain mixing ointment, add 7wt%'s PEG4000, is dried and makes capsule.
Embodiment 4
A kind of Chinese medicine composition improving body immunity, is made up of the raw material of following weight portion: the Radix Astragali 17 parts, Morchella esculenta (L.) Pers 17 parts, Herba Dendrobii 17 parts, Ganoderma 14 parts, the Cortex Eucommiae 14 parts, Fructus Ligustri Lucidi 14 parts, Radix Cynanchi Auriculati 14 parts, Carapax et Plastrum Testudinis 10 parts, Herba Ecliptae 10 parts, Fu Siberian cocklebur 10 parts, Radix Bupleuri 7 parts, Radix Scrophulariae 7 parts, Flos Lonicerae 7 parts, Radix Panacis Quinquefolii 7 parts, the Radix Aucklandiae 5 parts, Radix Rhodiolae 5 parts, Radix Ophiopogonis 5 parts, 3 parts of Radix Glycyrrhizae With Radix Apioris Fortunei (Radix Lespedezae Buergeri) 3 parts.
The preparation method of the Chinese medicine composition of this raising body immunity, including following preparation process:
1) weigh the Radix Astragali, Morchella esculenta (L.) Pers, Herba Dendrobii, Ganoderma, the Cortex Eucommiae, Fructus Ligustri Lucidi, Radix Cynanchi Auriculati, Carapax et Plastrum Testudinis, Herba Ecliptae, Poria, Radix Bupleuri, Radix Scrophulariae, Flos Lonicerae, Radix Panacis Quinquefolii, the Radix Aucklandiae, Radix Rhodiolae and Radix Ophiopogonis, cleaning, pulverize, add 1.6 times of weight parts waters, 38 DEG C are soaked 1.3 Hour；
2) by step 1) the raw material supersound extraction soaked, filter, collect extracting solution and filtering residue respectively, supersound extraction concrete Process conditions are: 83 DEG C, 1400 watts, 38 minutes extraction times；
3) by step 2) gained filtering residue regulation pH value be 7.0, add ethanol microwave extraction, collect extracting solution, microwave extraction Process conditions be: 70 DEG C, 280 watts, 18 minutes extraction times, solid-liquid ratio is 1 gram: 28 milliliters；
4) by step 2) and step 3) gained extracting solution merges, concentrates, 48 DEG C of vacuum dryings 2.6 hours；
5) weighing Radix Glycyrrhizae and Radix Apioris Fortunei (Radix Lespedezae Buergeri), clean, superfine powder is to 16 μm；
6) by step 5) products therefrom adds 1.8 times of weight parts waters, soaks 18 minutes, and 28 DEG C, 1600 revs/min, centrifugal 8 points Clock；
7) step 6 is collected) it is centrifuged the gained supernatant, is concentrated into water content 42wt%；
8) by step 4) products therefrom joins step 7) in products therefrom, obtain mixing ointment, adding weight ratio is 1:1's Sucrose and dextrin 7wt%, mix homogeneously, it is dried and makes powder.
Embodiment 5
A kind of Chinese medicine composition improving body immunity, is made up of the raw material of following weight portion: the Radix Astragali 19 parts, Morchella esculenta (L.) Pers 19 parts, Herba Dendrobii 19 parts, Ganoderma 15 parts, the Cortex Eucommiae 15 parts, Fructus Ligustri Lucidi 15 parts, Radix Cynanchi Auriculati 15 parts, Carapax et Plastrum Testudinis 8 parts, Herba Ecliptae 8 parts, Poria 8 Part, Radix Bupleuri 5 parts, Radix Scrophulariae 5 parts, Flos Lonicerae 5 parts, Radix Panacis Quinquefolii 5 parts, the Radix Aucklandiae 3 parts, Radix Rhodiolae 3 parts, Radix Ophiopogonis 3 parts, 1 part of Radix Glycyrrhizae and three Blue or green 1 part of leaf.
The preparation method of the Chinese medicine composition of this raising body immunity, including following preparation process:
1) weigh the Radix Astragali, Morchella esculenta (L.) Pers, Herba Dendrobii, Ganoderma, the Cortex Eucommiae, Fructus Ligustri Lucidi, Radix Cynanchi Auriculati, Carapax et Plastrum Testudinis, Herba Ecliptae, Poria, Radix Bupleuri, Radix Scrophulariae, Flos Lonicerae, Radix Panacis Quinquefolii, the Radix Aucklandiae, Radix Rhodiolae and Radix Ophiopogonis, cleaning, pulverize, add 1.8 times of weight parts waters, 40 DEG C are soaked 1.4 Hour；
2) by step 1) the raw material supersound extraction soaked, filter, collect extracting solution and filtering residue respectively, supersound extraction concrete Process conditions are: 84 DEG C, 1450 watts, 40 minutes extraction times；
3) by step 2) gained filtering residue regulation pH value be 7.1, add ethanol microwave extraction, collect extracting solution, microwave extraction Process conditions be: 71 DEG C, 290 watts, 19 minutes extraction times, solid-liquid ratio is 1 gram: 29 milliliters；
4) by step 2) and step 3) gained extracting solution merges, concentrates, 49 DEG C of vacuum dryings 2.7 hours；
5) weighing Radix Glycyrrhizae and Radix Apioris Fortunei (Radix Lespedezae Buergeri), clean, superfine powder is to 18 μm；
6) by step 5) products therefrom adds 1.9 times of weight parts waters, soaks 19 minutes, and 29 DEG C, 1700 revs/min, centrifugal 9 points Clock；
7) step 6 is collected) it is centrifuged the gained supernatant, is concentrated into water content 44wt%；
8) by step 4) products therefrom joins step 7) in products therefrom, obtaining mixing ointment, addition weight ratio is 1:2:1 Sucrose, dextrin and mannitol 8wt% mix homogeneously, be dried make pill.
Embodiment 6
A kind of Chinese medicine composition improving body immunity, is made up of the raw material of following weight portion: the Radix Astragali 20 parts, Morchella esculenta (L.) Pers 20 parts, Herba Dendrobii 20 parts, Ganoderma 12 parts, the Cortex Eucommiae 12 parts, Fructus Ligustri Lucidi 12 parts, Radix Cynanchi Auriculati 12 parts, Carapax et Plastrum Testudinis 8 parts, Herba Ecliptae 8 parts, Poria 8 Part, Radix Bupleuri 5 parts, Radix Scrophulariae 5 parts, Flos Lonicerae 5 parts, Radix Panacis Quinquefolii 5 parts, the Radix Aucklandiae 3 parts, Radix Rhodiolae 3 parts, Radix Ophiopogonis 3 parts, 1 part of Radix Glycyrrhizae and three Blue or green 1 part of leaf.
The preparation method of the Chinese medicine composition of this raising body immunity, including following preparation process:
1) weigh the Radix Astragali, Morchella esculenta (L.) Pers, Herba Dendrobii, Ganoderma, the Cortex Eucommiae, Fructus Ligustri Lucidi, Radix Cynanchi Auriculati, Carapax et Plastrum Testudinis, Herba Ecliptae, Poria, Radix Bupleuri, Radix Scrophulariae, Flos Lonicerae, Radix Panacis Quinquefolii, the Radix Aucklandiae, Radix Rhodiolae and Radix Ophiopogonis, cleaning, pulverize, add 1.9 times of weight parts waters, 44 DEG C are soaked 1.5 Hour；
2) by step 1) the raw material supersound extraction soaked, filters, collects extracting solution and filtering residue, the tool of supersound extraction respectively Body technology condition is: 85 DEG C, 1500 watts, 42 minutes extraction times；
3) by step 2) gained filtering residue regulation pH value be 7.2, add ethanol microwave extraction, collect extracting solution, microwave extraction Process conditions be: 72 DEG C, 300 watts, 20 minutes extraction times, solid-liquid ratio is 1 gram: 30 milliliters；
4) by step 2) and step 3) gained extracting solution merges, concentrates, 50 DEG C of vacuum dryings 2.8 hours；
5) weighing Radix Glycyrrhizae and Radix Apioris Fortunei (Radix Lespedezae Buergeri), clean, superfine powder is to 19 μm；
6) by step 5) products therefrom adds 2.0 times of weight parts waters, soaks 20 minutes, and 30 DEG C, 1800 revs/min, centrifugal 10 Minute；
7) step 6 is collected) it is centrifuged the gained supernatant, is concentrated into water content 46wt%；
8) by step 4) products therefrom joins step 7) in products therefrom, obtain mixing ointment, adding weight ratio is 1:2's Sucrose and poly-PEG4000 9wt% mix homogeneously, be dried and make unguentum.
Embodiment 7
A kind of Chinese medicine composition improving body immunity, is made up of the raw material of following weight portion: the Radix Astragali 15 parts, Morchella esculenta (L.) Pers 16 parts, Herba Dendrobii 17 parts, Ganoderma 12 parts, the Cortex Eucommiae 12 parts, Fructus Ligustri Lucidi 12 parts, Radix Cynanchi Auriculati 12 parts, Carapax et Plastrum Testudinis 8 parts, Herba Ecliptae 8 parts, Poria 8 Part, Radix Bupleuri 5 parts, Radix Scrophulariae 5 parts, Flos Lonicerae 5 parts, Radix Panacis Quinquefolii 5 parts, the Radix Aucklandiae 3 parts, Radix Rhodiolae 3 parts, Radix Ophiopogonis 3 parts, 1 part of Radix Glycyrrhizae and three Blue or green 1 part of leaf.
The preparation method of the Chinese medicine composition of this raising body immunity, including following preparation process:
1) weigh the Radix Astragali, Morchella esculenta (L.) Pers, Herba Dendrobii, Ganoderma, the Cortex Eucommiae, Fructus Ligustri Lucidi, Radix Cynanchi Auriculati, Carapax et Plastrum Testudinis, Herba Ecliptae, Poria, Radix Bupleuri, Radix Scrophulariae, Flos Lonicerae, Radix Panacis Quinquefolii, the Radix Aucklandiae, Radix Rhodiolae and Radix Ophiopogonis, cleaning, pulverize, add 2.0 times of weight parts waters, 46 DEG C are soaked 1.1 Hour；
2) by step 1) the raw material supersound extraction soaked, filter, collect extracting solution and filtering residue respectively, supersound extraction concrete Process conditions are: 81 DEG C, 1220 watts, 44 minutes extraction times；
3) by step 2) gained filtering residue regulation pH value be 7.4, add ethanol microwave extraction, collect extracting solution, microwave extraction Process conditions be: 74 DEG C, 260 watts, 17 minutes extraction times, solid-liquid ratio is 1 gram: 26 milliliters；
4) by step 2) and step 3) gained extracting solution merges, concentrates, 45 DEG C of vacuum dryings 3 hours；
5) weighing Radix Glycyrrhizae and Radix Apioris Fortunei (Radix Lespedezae Buergeri), clean, superfine powder is to 20 μm；
6) by step 5) products therefrom adds water 1.5 times of weight portions, soaks 15 minutes, and 25 DEG C, 1900 revs/min, centrifugal 5 points Clock；
7) step 6 is collected) it is centrifuged the gained supernatant, is concentrated into water content 48wt%；
8) by step 4) products therefrom joins step 7) in products therefrom, obtain mixing ointment, add the manna of 5wt% Alcohol, mix homogeneously, it is dried, adds appropriate hydrochloric acid regulation acidity, be configured, filter, embedding, injection is made in sterilizing and leak detection Agent.The complication of the immunologic hypofunction caused because of diabetes it is particularly well-suited to, directly with mannitol for the injection that adjuvant is made Connect drug administration by injection better.
Embodiment 8
A kind of Chinese medicine composition improving body immunity, is made up of the raw material of following weight portion: the Radix Astragali 20 parts, Morchella esculenta (L.) Pers 18 parts, Herba Dendrobii 16 parts, Ganoderma 15 parts, the Cortex Eucommiae 13 parts, Fructus Ligustri Lucidi 13 parts, Radix Cynanchi Auriculati 13 parts, Carapax et Plastrum Testudinis 8 parts, Herba Ecliptae 8 parts, Poria 10 parts, Radix Bupleuri 5 parts, Radix Scrophulariae 5 parts, Flos Lonicerae 5 parts, Radix Panacis Quinquefolii 5 parts, the Radix Aucklandiae 3 parts, Radix Rhodiolae 3 parts, Radix Ophiopogonis 3 parts, 3 parts of Radix Glycyrrhizae and Radix Apioris Fortunei (Radix Lespedezae Buergeri) 1 part.
The preparation method of the Chinese medicine composition of this raising body immunity, including following preparation process:
1) weigh the Radix Astragali, Morchella esculenta (L.) Pers, Herba Dendrobii, Ganoderma, the Cortex Eucommiae, Fructus Ligustri Lucidi, Radix Cynanchi Auriculati, Carapax et Plastrum Testudinis, Herba Ecliptae, Poria, Radix Bupleuri, Radix Scrophulariae, Flos Lonicerae, Radix Panacis Quinquefolii, the Radix Aucklandiae, Radix Rhodiolae and Radix Ophiopogonis, cleaning, pulverize, add 1.9 times of weight parts waters, 50 DEG C are soaked 1.5 Hour；
2) by step 1) the raw material supersound extraction soaked, filter, collect extracting solution and filtering residue respectively, supersound extraction concrete Process conditions are: 82 DEG C, 1320 watts, 45 minutes extraction times；
3) by step 2) gained filtering residue regulation pH value be 7.5, add ethanol microwave extraction, collect extracting solution, microwave extraction Process conditions be: 75 DEG C, 300 watts, 20 minutes extraction times, solid-liquid ratio is 1 gram: 30 milliliters；
4) by step 2) and step 3) gained extracting solution merges, concentrates, 50 DEG C of vacuum dryings 3 hours；
5) weighing Radix Glycyrrhizae and Radix Apioris Fortunei (Radix Lespedezae Buergeri), clean, superfine powder is to 20 μm；
6) by step 5) products therefrom adds 2.0 times of weight parts waters, soaks 20 minutes, and 30 DEG C, 2000 revs/min, centrifugal 10 Minute；
7) step 6 is collected) it is centrifuged the gained supernatant, is concentrated into water content 50wt%；
8) by step 4) products therefrom joins step 7) in products therefrom, obtain mixing ointment, add 10wt% dextrin, mixed Close uniformly, be dried and make pill.
In order to the present invention curative effect to treatment adrenocortical insufficiency is described, carry out clinical treatment experiment, its Clinical data is as follows:
Adrenocortical insufficiency can be divided into constitutional and the big class of idiopathic two.Primary adrenal cortical function subtracts Move back disease and be also called Addison disease, Thomas Addison in 1855 " deliver " opinion adrenal gland diseases are on whole body and the impact of local ", Describe the disease being characterized with Progressive symmetric erythrokeratodermia anemia, skin brown pigment calmness, muscle weakness, the weakest, blood pressure reduction etc., The Addison disease named with his surname the most later.
Addison disease mainly due to the reason such as autoimmune, infection destroy bilateral adrenal glands cortex the overwhelming majority and Cause caused by adrenocortical hormone hyposecretion, have Adrenal Glucocorticoid cortex liquor-saturated the most simultaneously and mineralocorticoid aldehyde is solid The performance of ketone hyposecretion.Idiopathic person is due to hypothalamus one hypophysis pathological changes or to use adrenocortical hormones in treating to cause rush Adrenocortical hormone deficiency causes adrenocortical hormone secretion to reduce.
Constitutional has the most identical clinical characters with idiopathic adrenal cortical hypofunction, the difference between them Mainly pigmentation.Melanocyte is to cause Pigmented reason, and blood plasma cortisol minimizing causes hypophysis to produce increases rush Fat element, because lipotropin or lipotrophic hormone, LPH has pigment cell excitement activity, produces Addison disease characteristic skin and mucosa hyperpigmentation.
One, the clinical research for the treatment of adrenocortical insufficiency:
Two, data and method
1. case-data
Clinical manifestation symptom is with pigmentation, loss of appetite, fatigue and weak as Early manifestation, and has dizziness, orthostatic low Blood pressure, Nausea and vomiting, abdominal distention, suffer from abdominal pain, suffer from diarrhoea, lose weight, hyposexuality, the lab testing such as pubes armpit hair is sparse, positive expectorant Can have multiple change, including hormonal readiness, routine blood test blood electrolyte etc., abnormal electrocardiographic pattern changes, sinus bradycardia etc. changes Become.Adrenal gland and the exception of hypophysis magnetic resonance.It is diagnosed as adrenocortical insufficiency according to clinical manifestation and auxiliary examination Totally 40 example, wherein male 20 example, women 20 example, the age 21 little year, maximum 70 years old.
2. research index
The partial clinical data of subordinate list 1 40 example patient and auxiliary examination
Note (on form middle kidney in adenohypophysis magnetic resonance item, not different from without exception for adrenal gland's hypophysis magnetic resonance examination ,-for nothing Adrenal gland's hypophysis magnetic resonance checks, other are adrenal gland's hypophysis magnetic resonance reflection performance).
All patients diagnosed, are randomly divided into matched group and experimental group, often organize 20 example patients.Matched group 20 example patient all take Hydrocortisone.Acate pneumonic tuberculosis person, needs actively to give antituberculosis therapy while hydrocortisone is treated；Idiopathic kidney Upper gland cortical hypofunction patient (i.e. idiopathic described in table, empty sellaturcica), needs while giving hydrocortisone Give thyroxine therapy；Because pituitary hormone lacks patient (i.e. pituitary tumor described in table postoperative, POMES), take hydrogenation can Need while pine to take the auxiliary treatment of corresponding hormone simultaneously；After adrenocortical adenoma excision, Multiple Endocrine gland merit The male patient of the symptom that can go down takes intramuscular injection human chorionic gonadotropin, propanoic acid beam ball ketone or ten while hydrocortisone The one emerald green ketone of acid promotes curative effect, and the female patient of seat antiperspirant syndrome uses estrogen and corpus luteum while taking hydrocortisone Ketone carries out artificial cycle treatment, and patients clinical symptom has and takes a turn for the better in various degree.Experimental group improves with the embodiment of the present invention 3 gained The Chinese medicinal composition granules of body immunity replaces hydrocortisone treatment, and other are the most identical.Below by way of subordinate list, this is described Invention gained improves effective effect of the Chinese medicine composition of body immunity.
Subordinate list 2: Contrast on effect
Recovery from illness Effective Effectively Invalid Add up to
Contrast groups 5 10 5 0 20
Experimental group 10 8 2 0 20
Illustrating that the Chinese medicine composition improving body immunity that the present invention obtains coordinates with medicine by subordinate list 2 can be effective Treatment adrenocortical insufficiency, and evident in efficacy, compared with existing medicine adrenocortical hormone hydrocortisone, bright Aobvious have more preferable therapeutic effect.
Equally, the present invention improves the Chinese medicine composition of the body immunity deficient patient of including of body function after iatrotechnics and puts Treat immunity function after chemotherapy (cellular immunization and humoral immunization) damage, the side such as lymphocyte nuclear DNA damage after Patients Treated by Radiotherapy, chemotherapy Pustule on the face effect is the most prominent, repeats the most one by one.
Finally illustrating, above example is only in order to illustrate technical scheme and unrestricted, and this area is common Other amendment or equivalents that technical scheme is made by technical staff, without departing from technical solution of the present invention Spirit and scope, all should contain in the middle of scope of the presently claimed invention.

Claims (8)

1. the Chinese medicine composition improving body immunity, it is characterised in that be made up of the raw material of following weight portion: the Radix Astragali 15 ～20 parts, Morchella esculenta (L.) Pers 15～20 parts, Herba Dendrobii 15～20 parts, Ganoderma 12～15 parts, the Cortex Eucommiae 12～15 parts, Fructus Ligustri Lucidi 12～15 parts, Radix Cynanchi Auriculati 12～15 parts, Carapax et Plastrum Testudinis 8～10 parts, Herba Ecliptae 8～10 parts, Poria 8～10 parts, Radix Bupleuri 5～7 parts, Radix Scrophulariae 5～7 parts, gold Flos Lonicerae 5～7 parts, Radix Panacis Quinquefolii 5～7 parts, the Radix Aucklandiae 3～5 parts, Radix Rhodiolae 3～5 parts, Radix Ophiopogonis 3～5 parts, Radix Glycyrrhizae 1～3 parts and Radix Apioris Fortunei (Radix Lespedezae Buergeri) 1～3 part.
A kind of Chinese medicine composition improving body immunity the most according to claim 1, it is characterised in that by following weight The raw material composition of part: the Radix Astragali 16 parts, Morchella esculenta (L.) Pers 18 parts, Herba Dendrobii 16 parts, Ganoderma 12 parts, the Cortex Eucommiae 12 parts, Fructus Ligustri Lucidi 12 parts, Radix Cynanchi Auriculati 13 parts, Carapax et Plastrum Testudinis 8 parts, Herba Ecliptae 8 parts, 9 parts of Poria, Radix Bupleuri 6 parts, Radix Scrophulariae 6 parts, Flos Lonicerae 6 parts, Radix Panacis Quinquefolii 6 parts, the Radix Aucklandiae 4 parts, red Herba hylotelephii erythrosticti 4 parts, Radix Ophiopogonis 4 parts, 3 parts of Radix Glycyrrhizae and Radix Apioris Fortunei (Radix Lespedezae Buergeri) 1 part.
3. a preparation method for the Chinese medicine composition of raising body immunity according to claim 1 and 2, its feature exists In, including following preparation process:
1) Radix Astragali, Morchella esculenta (L.) Pers, Herba Dendrobii, Ganoderma, the Cortex Eucommiae, Fructus Ligustri Lucidi, Radix Cynanchi Auriculati, Carapax et Plastrum Testudinis, Herba Ecliptae, Poria, Radix Bupleuri, profound is weighed Ginseng, Flos Lonicerae, Radix Panacis Quinquefolii, the Radix Aucklandiae, Radix Rhodiolae and Radix Ophiopogonis, clean, pulverize, add 1.0～2.0 times of weight parts waters, 30～50 DEG C Soak 1.0～1.5 hours；
2) by step 1) the raw material supersound extraction soaked, filters, collects extracting solution and filtering residue respectively；
3) by step 2) gained filtering residue regulation pH value be 6.5～7.5, add ethanol microwave extraction, collect extracting solution；
4) by step 2) and step 3) gained extracting solution merges, concentrates, is dried；
5) weigh Radix Glycyrrhizae and Radix Apioris Fortunei (Radix Lespedezae Buergeri), clean, superfine powder to 10～20 μm；
6) by step 5) products therefrom adds 1.5～2.0 times of weight parts waters, soaks 15～20 minutes, and 25～30 DEG C, 1500～2000 Rev/min, centrifugal 5～10 minutes；
7) step 6 is collected) the centrifugal gained supernatant, it is concentrated into water content 35～50wt%；
8) by step 4) products therefrom joins step 7) in products therefrom, obtain mixing ointment, add the adjuvant of 5～10wt%, Mix homogeneously, drying agent.
The preparation method of a kind of Chinese medicine composition improving body immunity the most according to claim 3, it is characterised in that Described step 2) in the concrete technology condition of supersound extraction be: 80～85 DEG C, 1200～1500 watts, extraction time 30～45 points Clock.
The preparation method of a kind of Chinese medicine composition improving body immunity the most according to claim 3, it is characterised in that Described step 3) in the process conditions of microwave extraction be: 65～75 DEG C, 250～300 watts, extraction time 15～20 minutes, feed liquid Ratio is 1 gram: 25～30 milliliters.
The preparation method of a kind of Chinese medicine composition improving body immunity the most according to claim 3, it is characterised in that Described step 4) in be dried be 45～50 DEG C, vacuum drying 2～3 hours.
The preparation method of a kind of Chinese medicine composition improving body immunity the most according to claim 3, it is characterised in that Described step 8) in adjuvant be one or more the combination in any in sucrose, dextrin, mannitol and poly-PEG4000.
8. according to the preparation method of a kind of Chinese medicine composition improving body immunity described in any one of claim 3～7, its Be characterised by, described step 8) in preparation include decoction, granule, tablet, capsule, powder, unguentum and pill.
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WO2020014745A1 (en) * 2018-07-18 2020-01-23 Mycelium Biotech Assets Pty Ltd Bioactive extract
CN112057546A (en) * 2020-09-08 2020-12-11 广东都市菜族农业科技有限公司 Propolis ganoderma lucidum spore powder composition and preparation method and application thereof

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CN103734428A (en) * 2013-12-31 2014-04-23 青岛恒波仪器有限公司 Glossy-privet-fruit health-care tea for improving immunity and preparation method of tea
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