CN1899363A - Chinese medicine composition for increasing immunity and its preparing method - Google Patents
Chinese medicine composition for increasing immunity and its preparing method Download PDFInfo
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- CN1899363A CN1899363A CN 200610103439 CN200610103439A CN1899363A CN 1899363 A CN1899363 A CN 1899363A CN 200610103439 CN200610103439 CN 200610103439 CN 200610103439 A CN200610103439 A CN 200610103439A CN 1899363 A CN1899363 A CN 1899363A
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Abstract
The present invention relates to a kind of Chinese medicine composition and its preparation process. The Chinese medicine composition has the functions of invigorating qi, nourishing blood, clearing away heat and toxic material and supporting the healthy energy, and may be used in treating leucopenia, immune deficiency, poor appetite, etc caused by different causes. The Chinese medicine composition is prepared with astragalus root, azolla, and leatherleaf milletia or angelica, and through decoction, ultrasonic extraction, microwave extraction or other preparation process, and may be in different preparation forms.
Description
(1) technical field
The present invention relates to a kind of Chinese medicine composition, this Chinese medicine composition has the function of vigorate qi and replenish the blood, heat-clearing and toxic substances removing, strengthening the body resistance; The pharmaceutical preparation that leukopenia, immunologic hypofunction, inappetence, fatigue and asthenia, dizziness are breathed hard, deficiency of both QI and blood is seen above-mentioned performance that be used to put, chemotherapy and a variety of causes causes, and the preparation method of this pharmaceutical preparation.
(2) background technology
The traditional Chinese medical science is thought, radiotherapy ray and chemotherapeutics belong to " heresy of pyretic toxicity ", in invade behind the human body easily yin-damaging and Qi consuming, decrease the smart liquid that burns, cause visceral dysfunction, have a strong impact on source of generating QI and blood, the disease that QIYINLIANGXU occurs, so put, leukopenia caused by cancer chemotherapy disease belongs to the deficiency syndrome category, its main pathogenesis and spleen kidney are in close relations, thus vigorate qi and replenish the blood, heat-clearing and toxic substances removing, strengthening the body resistance be alleviate put, leukopenic basic rule of treatment due to the chemotherapy.Based on the above cause of disease and the rule of treatment, mostly control, the leukopenia due to the chemotherapy is used is some air making-up and spleen enlivenings, replenishing YIN to strengthen the kidney if being put, the medicine such as invigorate blood circulation of enriching blood, as the Radix Astragali, Radix Codonopsis, Radix Angelicae Sinensis, Caulis Spatholobi, Colla Corii Asini etc.Chemotherapeutics is when suppressing or killing tumor cell, and particularly the toxicity of hematopoietic cell is very big to the active normal tissue cell of human body propagation, because bone marrow depression is serious, and influences patient treatment.Studies show that in recent years, Chinese medicine is in prevention, treatment or the auxiliary treatment of toxicity due to the malignant tumor chemotherapy, the energy strengthening the body resistance, attenuation synergistic, prolong life cycle, improve life quality, widened the prevention and treatment range of toxicity due to the malignant tumor chemotherapy, have a good application prospect, be worth further inquiring into.The Chinese medicine malignant tumor has good curative effect has become common recognition, famous tumor expert Sun Yan academician estimates, Chinese medicine " not only improved the clinical tumor curative effect, prolonged the survival rate of tumor and improved quality of life; and combine with operation, chemicotherapy, played synergism and attenuation ".
(3) summary of the invention
[problem that will solve]
One of purpose of the present invention provides a kind of Chinese medicine composition of enhance immunity, this Chinese medicine composition can effectively treat put, leukopenia, immunologic hypofunction, inappetence, fatigue and asthenia, dizziness that chemotherapy and a variety of causes cause are breathed hard, deficiency of both QI and blood is seen above-mentioned performance, and toxic and side effects is little.
Another object of the present invention provides the prescription and the preparation method of this Chinese medicine composition.
[technical scheme]
The inventor thinks through clinical practice for many years, the medicine that tumor patient radiotherapy and chemotherapy are used belongs to " heresy of pyretic toxicity ", in invade behind the human body easily yin-damaging and Qi consuming, decrease the smart liquid that burns, cause visceral dysfunction, have a strong impact on source of generating QI and blood, the disease that QIYINLIANGXU occurs, so put, leukopenia caused by cancer chemotherapy disease belongs to the deficiency syndrome category, its main pathogenesis and spleen kidney are in close relations, thus vigorate qi and replenish the blood, heat-clearing and toxic substances removing, strengthening the body resistance be alleviate put, leukopenic basic rule of treatment due to the chemotherapy.Based on the above cause of disease and the rule of treatment, mostly control, the leukopenia due to the chemotherapy is used is some air making-up and spleen enlivenings, replenishing YIN to strengthen the kidney if being put, the medicine such as invigorate blood circulation of enriching blood, as the Radix Astragali, Radix Codonopsis, Radix Angelicae Sinensis, Caulis Spatholobi, Colla Corii Asini etc.
Modern study shows that the Radix Astragali is rich in polysaccharide, multiple compositions such as saponin, aminoacid, protein, folic acid, flavonoid, riboflavin, vitamin, organic acid, coumarin, daucosterol, choline, betanin.Has invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, the effect of expelling pus and promoting granulation.It is weak to be used for the treatment of the deficiency of vital energy, anorexia and loose stool, and sinking of QI of middle-JIAO, the chronic diarrhea proctoptosis, the metrorrhagia of having blood in stool, the exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle is difficult bursts, and burst for a long time and do not hold back, the blood deficiency dull yellowish colored skin, interior-heat is quenched one's thirst; Chronic nephritis proteinuria, diabetes.Caulis Spatholobi contains multiple compositions such as plant sterol, flavonoid, formoononetin, ononin, prunusetin., coumarin, daucosterol, choline, betanin, has and enriches blood, and invigorates blood circulation the effect of collateral dredging.Be used for menoxenia, blood deficiency and yellow complexion, paralysis and numbness, rheumatic arthralgia.Duckweed claims " green Herba Marsileae Quadrifoliae ", " red Herba Marsileae Quadrifoliae ", " red duckweed " or Herba azollae imbricatae again, is born in paddy field or the hydrostatic pond, and body is little, the water surface that floats, spring green, summer bronzing.The duckweed crude drug source is Herba azollae imbricatae section plant (Azolla imbricata (Roxb.) Nakai). dry herb, fish for summer, removes impurity, in time dry the use.Duckweed has the effect of tool heat-clearing and toxic substances removing, reducing swelling and alleviating pain.Modern study shows that duckweed contains rich in amino acid, protein, polysaccharide, flavonoid and trace element, and its aqueous extract has radioprotective, leukocyte increasing, antidotal effect.Radix Angelicae Sinensis contains multiple compositions such as volatile oil, aminoacid, polysaccharide, trace element.The tradition Chinese medicine thinks that Radix Angelicae Sinensis has to enrich blood invigorates blood circulation, menstruction regulating and pain relieving, and the function of loosening bowel to relieve constipation is used for blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.Radix Astragali compatibility duckweed, Caulis Spatholobi or Radix Angelicae Sinensis have tangible leukocyte increasing, the effect of enhance immunity, can significantly improve because of leukopenia, immunologic hypofunction, inappetence, fatigue and asthenia, the dizziness of putting, chemotherapy and a variety of causes cause are breathed hard, deficiency of both QI and blood is seen above-mentioned performance, therefore, this Chinese medicine composition and pharmaceutical preparation thereof are adopted
With following prescription 1:
Radix Astragali 200--400 part duckweed 200--400 part Caulis Spatholobi 100--300 part.
One of purpose of the present invention is also to provide the Chinese medicine composition of the obvious enhance immunity of energy and the prescription 2 of pharmaceutical preparation thereof to be:
200 parts of 320 portions of Caulis Spatholobis of 350 portions of duckweeds of the Radix Astragali.
One of purpose of the present invention is also to provide the Chinese medicine composition of the obvious enhance immunity of energy and the prescription 3 of pharmaceutical preparation thereof to be:
Radix Astragali 300--400 part duckweed 300--350 part Radix Angelicae Sinensis 50--250 part.
One of purpose of the present invention is also to provide the Chinese medicine composition of the obvious enhance immunity of energy and the prescription 4 of pharmaceutical preparation thereof to be:
150 parts of 320 parts of Radix Angelicae Sinensis of 350 portions of duckweeds of the Radix Astragali.
The present invention also provides the obviously preparation method of the pharmaceutical preparation tablet of enhance immunity Chinese medicine composition, hard capsule, soft capsule, granule, powder, pill, drop pill, dry suspension, suspensoid, mixture, oral liquid, oral solution, Emulsion, syrup, medicated wine, tincture, medicinal tea, distillate medicinal water, suppository, lozenge, fluid extract, extractum, soft extract, colloid pharmaceutical preparation:
Preparation method 1: according to above-mentioned prescription 1 or 2 or 3 or 4, more than three the flavor, decoct with water extraction or supersound extraction or microwave extraction or supercritical extraction, extract fully, merge extractive liquid, filters, filtrate is condensed into clear paste, drying under reduced pressure is pulverized, and sieves, add an amount of adjuvant such as starch, dextrin, cellulose, hard magnesium again, according to the regulation of Chinese medicine preparation general rule, make various pharmaceutical dosage forms, promptly.
Preparation method 2: according to above-mentioned prescription 1 or 2 or 3 or 4, more than three the flavor medicines, all smash, mixing decocts with water extraction or supersound extraction or microwave extraction or supercritical extraction, extract fully, merge extractive liquid, filters, and filtrate is condensed into clear paste, adding adequate amount of ethanol makes the alcohol amount of containing reach 50%--75%, leave standstill more than 24 hours, get supernatant, filter, decompression recycling ethanol, filtrate is condensed into clear paste, adds an amount of adjuvant such as starch, dextrin, cellulose, hard magnesium again, according to the regulation of Chinese medicine preparation general rule, make various pharmaceutical dosage forms, promptly.
Preparation method 3: according to above-mentioned prescription 1 or 2 or 3 or 4, more than three the flavor medicines, all smash, every flavor prescription solely decocts with water extraction or supersound extraction or microwave extraction or supercritical extraction, extract fully, merge extractive liquid, filters, filtrate is condensed into clear paste, add adequate amount of ethanol and make and contain alcohol amount and reach 50%--75%, leave standstill more than 24 hours, get supernatant, filter, decompression recycling ethanol, filtrate is condensed into clear paste, adds adequate amount of ethanol again and makes the alcohol amount of containing reach 80%--90%, leave standstill more than 24 hours, get supernatant, filter decompression recycling ethanol, filtrate is condensed into clear paste, add an amount of adjuvant such as starch again, dextrin, cellulose, hard magnesium is according to the regulation of Chinese medicine preparation general rule, according to the regulation of Chinese medicine preparation general rule, make various pharmaceutical dosage forms, promptly.
Preparation method 4: according to above-mentioned prescription 1 or 2 or 3 or 4, more than three flavor medicines, all smash, separately or mix and decoct with water extraction or supersound extraction or microwave extraction or supercritical extraction, extract fully, merge extractive liquid, filters, and filtrate is condensed into clear paste, adding adequate amount of ethanol makes the alcohol amount of containing reach 60%--75%, leave standstill more than 24 hours, get supernatant, filter, decompression recycling ethanol, filtrate is condensed into clear paste, makes and contains alcohol amount and reach 80%--90% adding adequate amount of ethanol, leaves standstill more than 24 hours, get supernatant, filter, decompression recycling ethanol, filtrate is condensed into clear paste, add an amount of adjuvant such as starch again, dextrin, cellulose, hard magnesium, according to the regulation of Chinese medicine preparation general rule, make various pharmaceutical dosage forms, promptly.
Preparation method 5: according to above-mentioned prescription 1 or 2 or 3 or 4, more than three flavor medicines, all smash, add Different concentrations of alcohol reflux, extract, or percolation and extract, extract fully, merge extractive liquid, or percolate filter, decompression filtrate recycling ethanol is condensed into clear paste, and is standby; Medicinal residues decoct with water extraction again, extract fully, and collecting decoction filters, filtrate is condensed into clear paste, and two kinds of clear paste mixings sieve, with appropriate amount of auxiliary materials such as starch, dextrin, cellulose, hard magnesium, mixing according to the regulation of Chinese medicine preparation general rule, is made various pharmaceutical dosage forms, promptly.
(4) specific implementation method
Embodiment one
Embodiment 1: the method for preparing this pharmaceutical preparation tablet:
The first step: with preparation method 1-5
Second step: add an amount of adjuvant as starch, dextrin, magnesium stearate, microcrystalline Cellulose, hyprolose, methylcellulose, ethyl cellulose, Carboxymethyl cellulose sodium, silicon dioxide, aluminium hydroxide, ethanol, mixing, make the various tablets under the Chinese Pharmacopoeia tablet item, packing, promptly.
Embodiment 2: the method for preparing this pharmaceutical preparation capsule:
The first step: with preparation method 1-5
Second step: add an amount of adjuvant as starch, dextrin, sucrose, microcrystalline Cellulose, hyprolose, methylcellulose, ethyl cellulose, Carboxymethyl cellulose sodium, silicon dioxide, aluminium hydroxide, ethanol, mixing, make granule, make various capsules under the Chinese Pharmacopoeia capsule item again, promptly.
Embodiment 3: the method for preparing this pharmaceutical preparation granule:
The first step: with preparation method 1-5
Second step: add an amount of adjuvant as starch, dextrin, sucrose, microcrystalline Cellulose, hyprolose, methylcellulose, ethyl cellulose, Carboxymethyl cellulose sodium, mixing is made granule, packing, promptly.
Embodiment 4: the method for preparing this pharmaceutical preparation pill:
The first step: with preparation method 1-5
Second step: add an amount of adjuvant as Mel, water, starch, dextrin, microcrystalline Cellulose, hyprolose, methylcellulose, ethyl cellulose, Carboxymethyl cellulose sodium, silicon dioxide, aluminium hydroxide, mixing, make honeyed pill, the watered pill, paste pill, concentrated pill, wax pill and the micropill of ball-type or class ball-type, packing, promptly.
Embodiment 5: the method for preparing this pharmaceutical preparation powder:
The first step: with preparation method 1-5
Second step: direct packaging or add an amount of adjuvant as starch, dextrin, sucrose, microcrystalline Cellulose, hyprolose, methylcellulose, ethyl cellulose, Carboxymethyl cellulose sodium, silicon dioxide, aluminium hydroxide, ethanol, mixing, packing, promptly.
Embodiment 6: the method for preparing this pharmaceutical preparation mixture:
The first step: with preparation method 1-5
Second step: add an amount of adjuvant as sucrose, Mel, microcrystalline Cellulose, hyprolose, methylcellulose, ethyl cellulose, Carboxymethyl cellulose sodium, water, ethanol, antiseptic, mixing, packing, promptly.
Embodiment 7: the method for preparing this pharmaceutical preparation soft capsule:
The first step: with preparation method 1-5
Second step: adds an amount of adjuvant as: vegetable oil, glycerol, Cera Flava compacting or drip and make, packing, promptly.
Embodiment 8: the method for preparing this pharmaceutical preparation drop pill:
The first step: with preparation method 1-5
Second step: adds an amount of dressing as Polyethylene Glycol, gelatin, stearic acid, glyceryl monostearate, hydrogenated vegetable oil, ethanol, mixing splashes in condensed fluid liquid paraffin or the dimethicone, and condensed fluid is removed in the contraction condensation, packing, promptly.
Embodiment 9: the method for preparing this pharmaceutical preparation unguentum:
The first step: with preparation method 1-5
Second step: add an amount of adjuvant as starch, dextrin, sucrose, Mel, cellulose, antiseptic, ethanol, mixing, packing, promptly.
Embodiment 10: the method for preparing this pharmaceutical preparation medicinal tea:
The first step: with preparation method 1-5
Second step: add an amount of adjuvant as starch, dextrin, sucrose, Mel, cellulose, antiseptic, ethanol, mixing, packing, promptly.
Embodiment two
This Chinese medicine composition is that the inventor is according to Traditional Chinese medical theory, clinical experience in conjunction with 30 years, on the plinth of the immunologic hypofunction that contemporary distinguished veteran doctors of TCM treatment a variety of causes causes, sum up the result who concludes in conjunction with the modern Chinese medicine pharmacological research, the inventor makes capsule, tablet, granule according to above-mentioned preparation method with this Chinese medicine composition, and " anticancer Hematogenesis capsule (or sheet or granule) " by name observed through clinical use for many years, determined curative effect is not seen obvious toxic and side effects.
Model case:
1, Huang, man, 48 years old, people from Hebei, secondary school teachers, nineteen ninety-five rises and promptly feels epigastric discomfort, the time and glutted dull pain, after every heavy meal more so, through repeatedly the treatment fail the radical cure, be tending towards serious in May, 1997, the gastralgia discomfort, anorexia, the time and vomit, diarrhoea, just alternately occur as sheep stool, once arrived the inspection of Beijing institute of traditional Chinese medicine several times, all doubting is " gastric ulcer ", and October 14 gulped down the barium meal sheet to this institute once more and checks X-ray sheet finding: " stomach is hook; a small amount of fasting retention liquid; visible 5.0 * 3.3 centimetres of big or small niches of lesser gastric curvature vertical component effect, lower recess on the niche, near the coarse and loss of peristalsis of mucosa; tenderness is obvious; the no abnormal discovery of each of duodenum, is thought of as the possibility of malignant change of gastric ulcer, i.e. hospitalization; in capable exploratory laparotomy on October 29, after opening the abdominal cavity, because of internal organs (liver, spleen) extensively adhesion is by the consultation of doctors, still can't perform the operation, be diagnosed as late gastric cancer.The patient after a few days stomach liver pain endlessly, the pain of pressing very, upper abdomen can be touched and obvious lump, poor appetite, become thin, constipation such as sheep stool, the time and vomit, vomitus is an old, food debris is in taking " anticancer Hematogenesis capsule " treatment, pain relief after 15 days by the end of November, the stool deliquescing, appetite increases, and lump slightly dwindles after the course of treatment, after six courses of treatment, check that through attached institute of Medical University Of Chongqing lump disappears other transference cure substantially.
2, open * *, man, 40 years old, Guangdong, businessman, patient begin conscious lower abdominal pain in August, 1996, concurrent existing one swollen thing is with fear of cold, heating is done the barium enema of X line through the People's Hospital, Bao'an, Shenzhen, suspect the swollen thing of colon, the row exploratory laparotomy was performed the operation and was found that ascending colon was fixed in rear wall the same day at county people's hospital's hospitalization on June 20th, 1998, Immobility, there is sclerosis on the surface, uneven, ileocecus and also soaked into by tumor apart from the about 8 centimetres of ileums of ileocecus, mobility is little, transverse colon, backlash intestinal and nethike embrane thereof, bladder nest all have the big dissemination tuberosity of Semen phaseoli radiati, and granule matter is hard, the scleroma of the right lobe of liver outside one Semen arachidis hypogaeae size, consider that " the ascending colon cancer is extensively sent out " colon does not still have the phenomenon of blocking, if make ileum, transverse colon end-to-side anastomosis, then might extensively be transferred to anastomotic stoma because of tumor, organization healing is bad, send Shantou examination in hospital so get the lump tissue, and tumor is not done other processing, hospital's pathological replacement: the result is " an omentum majus metastatic carcinoma, may from large intestine ".Leave hospital behind patient's wound healing and go home, fluorouracil was injected 4 days in the back of leaving hospital, and the thiophene furan was sent 4 days, and anticancer tablet for oral administration, because of reacting violent drug withdrawal, patient's pain is day by day aggravated, constipation, band mucus blood, body constitution is become thin, the palpation stomach wall is nervous, the bottom right abdomen can lay one's hand on and fist size lump matter hard, surface irregularity, the edge is not whole, and activeness is poor, and obvious tenderness is arranged, upper abdomen also has tenderness, and it is streak that descending colon are, a plurality of lymphadenectasis of groin such as Semen Litchi.The patient begins clothes " anticancer Hematogenesis capsule " anticancer therapy on June 13rd, 1999, conscious pain subtracts slightly after 3 days, cooperate " FUFANG KUSHEN ZHUSHEYE " intravenously administrable after 10 days pain obviously alleviate, pain disappears substantially after one course of treatment, lump is than soft in the past, appetite increases the patient and constipation occurs, give each 30 milliliters of clothes Oleum Arachidis hypogaeae semen 2 times, the patient defecates normally after 22 days, stop during 3 courses of treatment administration " FUFANG KUSHEN ZHUSHEYE " continue clothes " anticancer Hematogenesis capsule " after the course of treatment health check-up abdominal mass dwindle 2/3, make the barium enema perspective, can fall, horizontal, the normal photo of ascending colon does not find that pathology X line levies, and does the check of barium enema and abdominal part photo March calendar year 2001: each section colon does not see that pathology X line levies.
3, Zhao * *, man, 40 years old, people from Zhuhai, patient check in BJ Union Hospital and diagnose out: ileocecus ascending colon mucus adenocarcinoma anaplastic, diffuse infiltrating, invade intestinal wall flesh layer, mesenteric lymph node shifts, and makes palliative operation in certain hospital, comes me institute to take " anticancer Hematogenesis capsule " treatment on May 8th, 1998, patient's pain relief after taking medicine, lump dwindles gradually, has no adverse reaction, and is existing still in treatment.
4, open * *, the woman, 50 years old, people from Qinghai, defecate band blood and mucus of enterpriser, patient is surplus half a year, and body is become thin gradually, do sigmoidoscopy in the People's Hospital, 9 Nikkei Qinghai August in 1997 and pathological section is diagnosed as sigmoid colon adenocarcinoma, on October 16th, 1997, capable sigmoidectomy was seen 4～5 Semen Glycines samples of right lobe of liver tuberosity in the art, and the sigmoid colon antetheca can reach the lump of 4 * 3 centimetres of sizes and invade and serous coat, art iv drip thiophene furan piperazine 500mg, for send 500mg flushing, postoperative is sick to be examined with thiophene in the abdominal cavity: " (sigmoid colon) burst soup type adenocarcinoma II level, tumor tissues is invaded and the intestinal wall holostrome " patient's art hands abdominal distention, stomachache, constipation, become thin, poor appetite, dizzy weak, began oral " anticancer Hematogenesis capsule " two months in January, 1998, weight in patients increases, and appetite strengthens, abdominal distention, stomachache disappears, daily inspection in March 16 in 1999: carcinoembryonic antigen, enzyme spectrum analysis, rocket albumen electricity edge, erythrocyte sedimentation rate is all in normal range, the patient is interrupted after February and took medicine for 2 courses of treatment, existing can orthobiosis.
5, Yu * *, the man, 43 years old, people from Jiangsu, in June, 1999, the patient suffered from abdominal pain, just defecation with blood and pus, darkish complexion, the tenesmus burning sensation of the anus, the time heavy when light, the bimester before the state of an illness increase the weight of, be blood during stool, the time as mashed meat, more than 20 time, sagging distention in the smaller abdomen, idol has formed stool, shape such as bar rope, the rectoscope report: rectoscope enters anus 7～8 centimeters mucous hyperemias the small-sized ulcer in 3～4 places, enters 14 centimeters again, visible one outstanding swollen thing, be cauliflower form, last adularescent mucosa, congestion and edema enters difficulty, pathological replacement: last noble cells cancer, be diagnosed as rectal cancer, the patient disagrees with operation, accepts chemotherapy, the patient is in October, 1999 anasarca, neurolysis, the anus causalgia arrives Shanghai again, various big hospitals such as Beijing are made to get involved the shooting frequency and are waited treatment, effect is not satisfactory, it is invalid January with Chinese herbal treatment to go home again, takes " anticancer Hematogenesis capsule " treatment, on April 25th, 2000 in March, 2000, patient main suit: diet increases, stool every day 1～2 time is shaped, and idol has borborygmus abdominal distention to continue to take medicine treatment, to transference cure in August calendar year 2001, stool every day 1 time, shape is normal, and spirit is fine, weight increase, calendar year 2001 December withdrawal, in February, 2002 proctoscopy: rectoscope is not seen ulcer and swollen thing by smoothly.
6, recklessly * *, man, 69 years old, people from Zhejiang, patient stomachache, stool are mixed and is stained with liquid half a year, and is invalid through controlling, examined at Zhejiang hospital hospitalization, anus in 1996: the rectum inwall touches swollen thing, fingerstall has courageous and upright mucus, and spectroscopy is seen adenocarcinoma cell, and the both sides groin touches the lymph node diagnosis of enlargement: advanced rectal cancer, because of patient year Gao Tixu, the operative treatment difficulty, and be reluctant to accept chemotherapy, and adopted thermotherapy 3 months, patient's lusterless complexion, poor appetite is weak, and the stomachache stool mixes pus and blood, soreness of waist cold extremities, anus treatment is received in external " anticancer bolt ", and effect is undesirable.Adopt " anticancer Hematogenesis capsule " oral medication after 10 days in February, 1998, patient's appetite increases, and spirit takes a turn for the better, stomachache disappears after one month, and bloody purulent stool disappears, and stool is ended normal, enclosed mass, lymphadenectasis is deliquescing, after three courses of treatment, swollen thing dwindles, and lymphadenectasis is disappeared, and takes medicine drug withdrawal after 2 years, through hospital's check, swollen thing disappears substantially, does not have new focus and occurs, do not have recurrence, do not have and shift.
Liu, man, 46 years old, the workman, the patient had blood in stool 2 years repeatedly, was diagnosed as rectal cancer in the attached institute of Chongqing medical college before 1 year, and implemented resection of rectal cancer, 9 days stool of patient's postoperative number of times increases day by day, through the doctor trained in Western medicine multi-treatment, produce little effect, through holding a consultation: see rectal tenesmus, the time desire defecation, just amount is few, and more so, anus to the sense of expanding disappears behind the defecation behind walking or the standing for a long time, but anus must be bitterly in a moment, stool examination: yellow skin is soft or shape pus cell (ten) mucus (ten) erythrocyte is a small amount of, and the patient is in treatment in January in this year oral " anticancer Hematogenesis capsule ", and further consultation in April, 2002: attached the expanding of anus alleviates to some extent behind the medicine, proctalgia disappears after an action of the bowels, day row 5～6 times, the stool examination feminine gender is given an oral account the rectal tenesmus sense recently and is faded away, defecate every day 1 time, existing still in the continuation treatment.
7, Xiao * *, woman, 73 years old, people from Shaanxi, the person finds the normal blood of stool in nineteen ninety-five, it is not smooth to defecate, proctalgia, just doubting is " hemorrhoid ", the state of an illness day by day increased the weight of in 1998, stool attenuates, with mucus and pus and blood, tenesmus, anus touch: have the swollen thing of cauliflower form easily hemorrhage, narrow in the form of a ring apart from meter, anus 7～800, be reported as " rectal adenocarcinoma I-II level " through biopsy pathology and refuse operation owing to patient is worn with age, taked treatment by Chinese herbs 1 year in 1999, the state of an illness does not increase the weight of, and in JIUYUE, 2000 patient times of defecation increases, many mucus and blood and slime, freeze shape as fish, anal incontinence is weighed down and is expanded unbearably, and the edema of the face begins to take " anticancer Hematogenesis capsule " treatment in October, 200, remission after 14 days, after two courses of treatment, times of defecation is normal, and weighing down expands disappears, edema disappears, check after half a year, lump dwindles, and existing conditions of patients is basicly stable, because economic conditions adopt and are interrupted medication treatment.
8, Guo * *, woman, 50 years old, people from Nanjing, patient have the dysmenorrhea medical history in 8 years, and leucorrhea frequently down, increase special stench, a purple blood of stream later on gradually, it is more serious to work, make pain during uterine part, rumpbone and waist basin bone deep are like fiery scorching hot pain, sometimes as thorn as cut, though year surplus 50 menstruation still have repeatedly menstrual onset to amortization period in month, through after also have secretions (leucorrhea) to continuously outflow, have blood and slime concurrently together, several years, in November, 1997, stagnant blood is fainted greatly down immediately, rescue through certain hospital, though blood ends, disease does not eliminate, muddy mucus is the quartzy transparent body, frequently following constantly general edema gradually is hard and dry urinary incontinence, pain is drenched in time sense, all feel tenesmus of front and back, diet reduces, the gastral cavilty heating.Because obstinate disease, extremity are aching and limp thereupon, lethargy, the bed several months can not take action, and asks local medical treatment invalid, comes the outpatient service of Deyang City central hospital subsequently, through gynecological's toposcopy, really be cervical cancer, the patient face edema, it is very dense to discharge red white mucus foul smell, began to take " anticancer Hematogenesis capsule " treatment in 1998, after 13 days, blood loses, diet heightens, spirit is good, and self energy is gone out for a walk after two courses of treatment, but vagina still has yellow fluid and descends, off and on, yellow fluid sees that situation takes a turn for the better gradually, patient's symptom complete obiteration after three courses of treatment less after two courses of treatment, get well, do not have recurrence so far.
9, poplar * *, woman, 35 years old, people from Guangxi, company clerk, patient are just producing 3 times, after contracting before often catching up with by the moon, few through measuring, leucorrhea is heavy at ordinary times, color is white, is rheum, frowziness, went to a doctor in 1997 in Beihai emigrant Hongkong people people hospital, symptom was at that time: hypogastric region and waist expand, clean 20 days of menstruation, vagina is bled again incessantly, cervical erosion was diagnosed as cervicitis at that time, embrocated red medicine treatment next day of once, patient's condition does not reduce to June in the same year, have a pain more very night in big abdomen both sides, each motion is violent a little, the vagina water of promptly bleeding, leucorrhea is still heavy, yellow skin, foul smell; Face upward that head promptly swoons, gynecologial examination: cervix uteri and vaginal mucosa color are normal, and cervix uteri is slightly rotten to the corn, and touching promptly has a little blood to flow out, there is tenderness in fallopian tube district, right side, and Radix Angelicae Sinensis is examined and is " cervical erosion, chronic pelvic inflammatory disease ", checked through health station in 1998, beginning is suspected carcinous change, after biopsy proves to be strictly " epithelial cancer ", check to the Sichuan hospital attached to a medical college in November, 1998, pathological diagnosis is a dermoid cancer on the early stage cervix uteri, uses DDP, and per 3 all repetitive therapy once.Do cytolgical examination in April, 1999, still have cancerous cell, begin patient's waist abdomen in May, 1999 and have a pain, foot is swollen, leucorrhea is more than beginning to take " anticancer Hematogenesis capsule " oral medication in August, 1999, and stomachache disappears after 20 days, and leucorrhea reduces, foot is swollen to be alleviated, and cures the further consultation of attached institute after two courses of treatment again to the river, and the result shoals for vagina, there is grey colour cell to form tissue, hypertrophy, cervical orifice dwindle, and fornix shoals, and the uterus is normal, cut sections for microscopic examination in the end of the year in the same year result, cancer-free cell.
10, wish * *, woman, 40 years old, people from Shandong, summer in 1997, the self-induction lower abdomen has an enclosed mass, and Shi Youwei is painful, gradually sees increase in 1998, and pain exacerbates thereupon, satisfies to the county hospital inspection, impression is " mucous cystadenocarcinoma of ovary ", and conclusion is " the uterus adnexa cancer shifts to the basin sidewall, can't perform the operation ".Advise the nutrition adjustment of going home, prolong life in spite of illness with the Ji, the patient begins to take " anticancer Hematogenesis capsule " treatment in May, 1998, the patient becomes thin before the treatment, be unable to leave the bed, lower abdomen has uneven that the big enclosed mass distending pain of two fists lays one's hand on approximately, and poor appetite was not defecated on the 7th or eight, 8 days stomachache of medication alleviates, appetite strengthens, and the lower abdomen enclosed mass dwindles gradually after 25 days, and diet is as usual, in June, the 1999 lower abdomen enclosed mass of taking medicine disappears substantially, make examination of castoff cells to Shandong Province institute October calendar year 2001, do not find cancerous cell, existing still alive.
Claims (10)
1, a kind of function with vigorate qi and replenish the blood, heat-clearing and toxic substances removing, strengthening the body resistance; Leukopenia, immunologic hypofunction, inappetence, fatigue and asthenia, the dizziness that be used to put, chemotherapy and a variety of causes causes breathed hard, the Chinese medicine composition and the pharmaceutical preparation thereof of deficiency of both QI and blood, and its prescription 1 is:
Radix Astragali 200--400 part duckweed 200--400 part Caulis Spatholobi 100--300 part.
2, Chinese medicine composition according to claim 1 and pharmaceutical preparation thereof is characterized in that the prescription 2 of said Chinese medicine composition is:
200 parts of 320 portions of Caulis Spatholobis of 350 portions of duckweeds of the Radix Astragali.
3, Chinese medicine composition according to claim 1 and pharmaceutical preparation thereof is characterized in that the prescription 3 of said Chinese medicine composition is:
Radix Astragali 300--400 part duckweed 300--350 part Radix Angelicae Sinensis 50--250 part.
4, Chinese medicine composition according to claim 1 and pharmaceutical preparation thereof is characterized in that the prescription 4 of said Chinese medicine composition is:
150 parts of 320 parts of Radix Angelicae Sinensis of 350 portions of duckweeds of the Radix Astragali.
5, according to claim 1 or 2 or 3 or 4 described Chinese medicine composition and pharmaceutical preparatioies thereof, the preparation method that it is characterized in that said Chinese medicine composition and pharmaceutical preparation thereof is: above three flavors, decoct with water extraction or supersound extraction or microwave extraction or supercritical extraction, extract fully, merge extractive liquid,, filter, filtrate is condensed into clear paste, drying under reduced pressure is pulverized, and sieves, add an amount of adjuvant such as starch, water, ethanol, dextrin, cellulose, hard magnesium again, according to the regulation of Chinese medicine preparation general rule, make various pharmaceutical dosage forms, promptly.
6, according to claim 1 or 2 or 3 or 4 described Chinese medicine composition and pharmaceutical preparatioies thereof, the preparation method that it is characterized in that said Chinese medicine composition and pharmaceutical preparation thereof is: above three flavor medicines, all smash, mixing, decoct with water extraction or supersound extraction or microwave extraction or supercritical extraction, extract fully, merge extractive liquid, filters, and filtrate is condensed into clear paste, adding adequate amount of ethanol makes the alcohol amount of containing reach 50%--75%, leave standstill more than 24 hours, get supernatant, filter, decompression recycling ethanol, filtrate is condensed into clear paste, adds an amount of adjuvant such as starch again, water, ethanol, dextrin, cellulose, hard magnesium is according to the regulation of Chinese medicine preparation general rule, make various pharmaceutical dosage forms, promptly.
7, according to claim 1 or 2 or 3 or 4 described Chinese medicine composition and pharmaceutical preparatioies thereof, the preparation method that it is characterized in that said Chinese medicine composition and pharmaceutical preparation thereof is: above three flavor medicines, all smash, every flavor prescription solely decocts with water extraction or supersound extraction or microwave extraction or supercritical extraction, extract fully, merge extractive liquid, filters, filtrate is condensed into clear paste, add adequate amount of ethanol and make and contain alcohol amount and reach 50%--75%, leave standstill more than 24 hours, get supernatant, filter, decompression recycling ethanol, filtrate is condensed into clear paste, adds adequate amount of ethanol again and makes the alcohol amount of containing reach 80%--90%, leave standstill more than 24 hours, get supernatant, filter decompression recycling ethanol, filtrate is condensed into clear paste, add an amount of adjuvant such as starch again, water, ethanol, dextrin, cellulose, hard magnesium is according to the regulation of Chinese medicine preparation general rule, according to the regulation of Chinese medicine preparation general rule, make various pharmaceutical dosage forms, promptly.
8, according to claim 1 or 2 or 3 or 4 described Chinese medicine composition and pharmaceutical preparatioies thereof, the preparation method that it is characterized in that said Chinese medicine composition and pharmaceutical preparation thereof is: above three flavor medicines, all smash, separately or mix and decoct with water extraction or supersound extraction or microwave extraction or supercritical extraction, extract fully, merge extractive liquid, filters, and filtrate is condensed into clear paste, adding adequate amount of ethanol makes the alcohol amount of containing reach 60%--75%, leave standstill more than 24 hours, get supernatant, filter, decompression recycling ethanol, filtrate is condensed into clear paste, makes and contains alcohol amount and reach 80%--90% adding adequate amount of ethanol, leaves standstill more than 24 hours, get supernatant, filter, decompression recycling ethanol, filtrate is condensed into clear paste, add an amount of adjuvant such as starch again, water, ethanol, dextrin, cellulose, hard magnesium, according to the regulation of Chinese medicine preparation general rule, make various pharmaceutical dosage forms, promptly.
9, according to claim 1 or 2 or 3 or 4 described Chinese medicine composition and pharmaceutical preparatioies thereof, the preparation method that it is characterized in that said Chinese medicine composition and pharmaceutical preparation thereof is: above three flavor medicines, all smash, add Different concentrations of alcohol reflux, extract, or percolation and extract, extract fully merge extractive liquid, or percolate, filter, decompression filtrate recycling ethanol is condensed into clear paste, and is standby; Medicinal residues decoct with water extraction again, extract fully, and collecting decoction filters, filtrate is condensed into clear paste, and two kinds of clear paste mixings sieve, with appropriate amount of auxiliary materials such as starch, water, ethanol, dextrin, cellulose, hard magnesium, mixing according to the regulation of Chinese medicine preparation general rule, is made various pharmaceutical dosage forms, promptly.
10,, it is characterized in that said Chinese medicine composition and pharmaceutical preparation thereof are under the Chinese Pharmacopoeia appendix item: tablet, capsule, granule, pill, powder, mixture, soft capsule, drop pill, unguentum, oral drug preparation according to described Chinese medicine composition of claim 1-9 and pharmaceutical preparation thereof.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102462730A (en) * | 2010-11-11 | 2012-05-23 | 陈建萍 | Chinese medicinal composition for treating tumors |
| CN105902827A (en) * | 2016-02-03 | 2016-08-31 | 驻马店市农业科学院 | Traditional Chinese medicine composition for improving immunity of human body and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1726939A (en) * | 2004-07-30 | 2006-02-01 | 周慧明 | Combination of medication for radiation hardening and preparation method |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102462730A (en) * | 2010-11-11 | 2012-05-23 | 陈建萍 | Chinese medicinal composition for treating tumors |
| CN102462730B (en) * | 2010-11-11 | 2013-12-25 | 陈建萍 | Traditional Chinese medicine composition for treating tumors |
| CN105902827A (en) * | 2016-02-03 | 2016-08-31 | 驻马店市农业科学院 | Traditional Chinese medicine composition for improving immunity of human body and preparation method thereof |
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