CN102048831A - Traditional Chinese medicine for treating cirrhosis - Google Patents

Traditional Chinese medicine for treating cirrhosis Download PDF

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CN102048831A
CN102048831A CN2010106038837A CN201010603883A CN102048831A CN 102048831 A CN102048831 A CN 102048831A CN 2010106038837 A CN2010106038837 A CN 2010106038837A CN 201010603883 A CN201010603883 A CN 201010603883A CN 102048831 A CN102048831 A CN 102048831A
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chinese medicine
traditional chinese
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liver
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刘新壮
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Lvyuan Qiuzheng Technology Development Co Ltd
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Lvyuan Qiuzheng Technology Development Co Ltd
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Abstract

The invention relates to a traditional Chinese medicine for treating cirrhosis, and belongs to the field of traditional Chinese medicines for treating digestive system diseases. The traditional Chinese medicine aims to have a good effect and quick response. The traditional Chinese medicine is prepared from Chinese lobelia herb, glossy ganoderma, Chinese angelica, notoginseng root, mulberry fruit, turtle shell and the like which serve as raw materials, has the effects of strengthening body resistance and archaeus, supplementing qi and nourishing blood, nourishing and softening liver, softening hardness to dissipate stagnation, promoting blood circulation by removing blood stasis and stopping pain, and has the advantages of obvious effect, definite curative effect and quick response.

Description

一种治疗肝硬化的中药A kind of traditional Chinese medicine for treating liver cirrhosis

技术领域technical field

本发明属于治疗消化系统疾病的中药领域。The invention belongs to the field of traditional Chinese medicine for treating digestive system diseases.

背景技术Background technique

目前用于治疗肝硬化的中药,存在两个方面的不足:一是效果不够明显,二是见效比较迟缓,以致于大批肝硬化患者因肝的纤维化不断加重,最后引发消化道出血、肝性脑病等并发症而死亡。患者及其家属对此不满意。There are two deficiencies in the traditional Chinese medicine currently used for the treatment of liver cirrhosis: one is that the effect is not obvious enough, and the other is that the effect is relatively slow, so that a large number of patients with liver cirrhosis continue to aggravate due to liver fibrosis, and finally cause gastrointestinal bleeding, liver disease, etc. Death from complications such as encephalopathy. Patients and their families are not happy with this.

针对以上提出的问题,本发明提供一种治疗肝硬化的中药,它能解决以往此类中药治疗中效果不够明显,见效比较迟缓的问题,效果好、见效快,具有效果显著,药效确切,见效较快的优点。In view of the problems raised above, the present invention provides a traditional Chinese medicine for the treatment of liver cirrhosis, which can solve the problem that the effect of this type of traditional Chinese medicine is not obvious enough and the effect is relatively slow in the past. The advantage of quicker results.

发明内容Contents of the invention

本发明是通过以下技术方案来实现的:The present invention is achieved through the following technical solutions:

1、一种治疗肝硬化的中药,采用中药原料制备,配方为(按重量比):1. A traditional Chinese medicine for treating liver cirrhosis, prepared from raw materials of traditional Chinese medicine, the formula is (by weight):

半边莲6——18份                      灵芝6——18份                      当归6——18份Lobelia 6—18 parts Lingzhi 6—18 parts Angelica 6—18 parts

三七3——9份                           桑椹6——18份                      鳖甲6——18份Panax notoginseng 3—9 parts Mulberry 6—18 parts Turtle shell 6—18 parts

这种治疗肝硬化的中药是由下列方法制成的:This traditional Chinese medicine for liver cirrhosis is made by the following methods:

(1)按上述重量比,将灵芝用水提醇沉法提取灵芝多糖,工艺流程如下:将灵芝破碎成颗粒状,过40目筛用1:20的热水(95℃)浸提浸提液减压、浓缩用3倍体积的95%乙醇混合、静置10—12小时、离心加75%的乙醇,沉淀多糖烘干得灵芝多糖提取物细粉;(1) According to the above weight ratio, extract Ganoderma lucidum polysaccharides from Ganoderma lucidum with water extraction and alcohol precipitation method. The process is as follows: Break Ganoderma lucidum into granules, pass through a 40-mesh sieve leaching with 1:20 hot water (95°C) leaching Extract the liquid under reduced pressure, concentrate mix with 3 times the volume of 95% ethanol, let stand for 10-12 hours, centrifuge add 75% ethanol, precipitate polysaccharide dry to obtain fine powder of Ganoderma lucidum polysaccharide extract;

(2)按上述重量比,将半边莲、当归、桑椹、鳖甲经常规水提取工艺提取,制成提取物浸膏细粉;(2) According to the above weight ratio, extract lobelia, angelica, mulberry and turtle shell through conventional water extraction process to make extract powder;

(3)按上述重量比,将三七研成细粉,与上述(1)、(2)两种提取物细粉混合,搅拌均匀,制成中药颗粒剂、胶囊剂、片剂。(3) Grind notoginseng into fine powder according to the above weight ratio, mix with the fine powder of the above two kinds of extracts (1) and (2), stir evenly, and make traditional Chinese medicine granules, capsules, and tablets.

本发明根据民间传统配方,根据中医扶正培本、活血化瘀的理论,精心研制而成。我们研究认为,免疫力低下,正气不足,是肝纤维化、肝硬化发生发展及转归的决定性因素。该病所以“难治”,称之“顽疾”, 所以效果“低微”,久治不愈,根本的原因就在于对机体免疫力(扶正)的决定性作用,认识上不够,力度还不大。据此,本发明以扶正为重点,结合肝硬化尤其是病毒性肝炎后肝硬化的病理特征,采用扶正培本,益气养血,活血化瘀,清热解毒,软坚散结,取得显著效果。这种疗效的显著性突出表现在两个方面:一是难以克服的“肝区隐痛”明显缓解,甚至完全消失;二是难以实现的 “肝纤维化逆转” 基本或完全实现。本方之中灵芝、桑椹扶正培本,益气养血,补益五脏,增强机体免疫力;当归、三七养血生血,活血化瘀止痛,养肝柔肝;伍以半边莲清热解毒,利尿消肿,以抑制肝腹水;鳖甲益阴而除热,破血而软坚散结,以缓解肝纤维化。诸药配伍,相得益彰,共奏扶正培本,益气养血、养肝柔肝,软坚散结,活血化瘀止痛之功,效果好,见效快,具有效果显著,药效确切,见效较快的优点。The present invention is elaborately developed according to the folk traditional formula and the theory of traditional Chinese medicine of strengthening the body and strengthening the body, promoting blood circulation and removing blood stasis. Our research believes that low immunity and lack of righteousness are the decisive factors for the development and outcome of liver fibrosis and liver cirrhosis. The reason why the disease is "refractory" and called "persistent disease", so the effect is "low", and it cannot be cured for a long time, the fundamental reason is that the decisive effect on the body's immunity (strengthening) is not enough, and the strength is not strong. Accordingly, the present invention focuses on strengthening the body, and in combination with the pathological characteristics of liver cirrhosis, especially post-viral hepatitis cirrhosis, adopts strengthening body, nourishing qi and blood, promoting blood circulation and removing blood stasis, clearing away heat and detoxification, softening hard masses and resolving stagnation, achieving remarkable effects. The remarkable effect of this effect is manifested in two aspects: first, the insurmountable "dull pain in the liver area" is significantly relieved, or even completely disappeared; second, the difficult-to-achieve "hepatic fibrosis reversal" is basically or completely realized. In this prescription, Ganoderma lucidum and mulberry strengthen the body, nourish qi and blood, nourish the five internal organs, and enhance the body's immunity; Detumescence, to suppress liver ascites; Biejia tonifies yin and removes heat, breaks blood and softens hard masses, so as to relieve liver fibrosis. All the medicines are compatible and complement each other. They play a role of strengthening the body, nourishing qi and nourishing blood, nourishing the liver and softening the liver, softening and resolving hard masses, promoting blood circulation, removing blood stasis and relieving pain. The effect is good and the effect is fast. The advantages.

具体实施方式Detailed ways

通过以下实施方式对本发明做具体说明:The present invention is specifically described by the following embodiments:

1、取以下配方(重量按克为单位):1. Take the following formula (weight in grams):

半边莲70克                            灵芝70克                            当归70克70g Lobelia 70g Ganoderma lucidum 70g Angelica

三七30克                           桑椹70克                            鳖甲70克30 grams of notoginseng 70 grams of mulberries 70 grams of turtle shells

按规定重量,用水提醇沉法将灵芝进行提取;用常规水提取工艺将半边莲、当归、桑椹、鳖甲提取,共制成提取物细粉70克,将三七研成细粉,与上述提取物细粉混合,搅拌均匀,制成细小颗粒,装入0号胶囊,制成中药胶囊357粒,每粒胶囊内含中药细粉及提取物0.28克。Extract Ganoderma lucidum by water extraction and alcohol precipitation method according to the specified weight; extract lobelia, angelica, mulberry, and turtle shell with conventional water extraction process, and make a total of 70 grams of extract fine powder, grind Panax notoginseng into fine powder, and The above-mentioned extract fine powders are mixed, stirred evenly, made into fine particles, packed into No. 0 capsules, and made into 357 Chinese medicine capsules, each capsule containing Chinese medicine fine powder and 0.28 grams of extract.

2、取以下配方(重量按克为单位):2. Take the following formula (the weight is in grams):

半边莲120克                     灵芝120克                           当归120克120g lobelia 120g ganoderma lucidum 120g angelica

三七50克                           桑椹120克                           鳖甲120克Panax notoginseng 50g mulberry 120g turtle shell 120g

按上述同样的方法,制成中药胶囊607粒,每粒胶囊内含中药细粉及提取物0.28克。By the above-mentioned same method, 607 Chinese medicine capsules were made, and each capsule contained 0.28 grams of Chinese medicine fine powder and extract.

3、取以下配方(重量按克为单位):3. Take the following formula (the weight is in grams):

半边莲180克                     灵芝180克                           当归180克180g lobelia 180g ganoderma lucidum 180g angelica

三七80克                           桑椹180克                           鳖甲180克80 grams of Panax notoginseng 180 grams of mulberries 180 grams of turtle shells

按上述同样的方法,制成中药胶囊928粒,每粒胶囊内含中药细粉及提取物0.28克。By above-mentioned same method, make 928 Chinese medicine capsules, every capsule contains Chinese medicine fine powder and extract 0.28 gram.

4、取以下配方(按重量比):4. Take the following formula (by weight ratio):

半边莲9份                              灵芝9份                        当归9份9 parts of Lobelia 9 parts of Ganoderma lucidum 9 parts of Angelica

三七4份                                       桑椹9份                        鳖甲9份4 parts of Panax notoginseng 9 parts of mulberry 9 parts of turtle shell

按上述同样的方法,制成中药胶囊,每粒胶囊内含中药细粉及提取物0.28克。By the above-mentioned same method, Chinese medicine capsules are made, and each capsule contains 0.28 grams of Chinese medicine fine powder and extract.

5、取以下配方(按重量比):5. Take the following formula (by weight ratio):

半边莲17份                            灵芝17份                       当归17份17 parts of Lobelia 17 parts of Ganoderma lucidum 17 parts of Angelica

三七7份                                  桑椹17份                       鳖甲17份7 parts of Panax notoginseng 17 parts of mulberry 17 parts of turtle shell

按上述同样的方法,制成中药胶囊,每粒胶囊内含中药细粉及提取物0.28克。By the above-mentioned same method, Chinese medicine capsules are made, and each capsule contains 0.28 grams of Chinese medicine fine powder and extract.

临床资料:clinical information:

本发明以中医肝硬化为例,经9例临床观察。选择中医诊断肝硬化为标准:肢软乏力,浑身没劲;腹胀、恶心、上腹隐痛;肝肿大、质地偏硬;黄疸、贫血或有出血倾向;出现肝掌、蜘蛛痣、皮肤色素沉着及浮肿等。如上症状,即可确诊。在确诊观察的对象中,男性5例,女性4例,无其它严重疾病,年龄为53岁—82岁,平均年龄67.4岁。The present invention takes liver cirrhosis of traditional Chinese medicine as an example, through 9 cases of clinical observation. TCM diagnosis of liver cirrhosis was selected as the standard: limb weakness, lack of energy; abdominal distension, nausea, upper abdominal pain; hepatomegaly, hard texture; edema etc. The above symptoms can be diagnosed. Among the confirmed observation objects, there were 5 males and 4 females, without other serious diseases, ranging in age from 53 to 82 years old, with an average age of 67.4 years.

疗效判定:Judgment of curative effect:

1、显效:乏力消失,肢体有力;腹胀、恶心、上腹隐痛明显缓解;贫血和肝面容明显缓解,脸色白皙,出现红润;浮肿消失;肝纤维化检查指标明显缓解。1. Significant effect: fatigue disappears, limbs are strong; abdominal distension, nausea, and upper abdominal pain are significantly relieved; anemia and liver complexion are significantly relieved, the complexion is fair and rosy; edema disappears; liver fibrosis test indicators are significantly relieved.

2、有效:身上有劲;腹胀、恶心、呕吐、贫血、浮肿等有所缓解。2. Effective: the body is strong; abdominal distension, nausea, vomiting, anemia, edema, etc. are relieved.

3、无效:病症无变化。3. Ineffective: no change in symptoms.

临床实验时,停服其它药物和保健营养品。服用本发明中药胶囊,观察6个月,为一个疗程。服用方法:每日2次,每次4粒胶囊,每粒胶囊内含中药细粉及提取物0.28克,饭后温开水送服,1个月后症状即有缓解,服用6个月后,症状明显改善。临床实验的9人中,显效4人,有效4人,无效1人,总有效率88.8%。During the clinical trial, stop taking other medicines and health nutrition products. Take Chinese medicine capsule of the present invention, observe 6 months, be a course of treatment. Dosing method: 2 times a day, 4 capsules each time, each capsule contains 0.28 grams of fine powder and extract of traditional Chinese medicine, take it with warm water after meals, the symptoms will be relieved after 1 month, and after 6 months of taking, Symptoms improved significantly. Among the 9 people in the clinical trial, 4 were markedly effective, 4 were effective, and 1 was ineffective, with a total effective rate of 88.8%.

Claims (1)

1. Chinese medicine for the treatment of liver cirrhosis, it is characterized in that: it is to make with the component of following weight ratio: Herba Lobeliae Chinensis 6---18 parts, Ganoderma 6---18 parts, Radix Angelicae Sinensis 6---18 parts, Radix Notoginseng 3---9 parts, Fructus Mori 6---18 parts, Carapax Trionycis 6---18 parts.
CN2010106038837A 2010-12-24 2010-12-24 Traditional Chinese medicine for treating cirrhosis Pending CN102048831A (en)

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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102302558A (en) * 2011-10-10 2012-01-04 北京绿源求证科技发展有限责任公司 Chinese medicament for treating hepatocirrhosis
CN102379923A (en) * 2011-09-03 2012-03-21 北京绿源求证科技发展有限责任公司 Traditional Chinese medicine for treating cirrhosis
CN102379924A (en) * 2011-09-27 2012-03-21 北京绿源求证科技发展有限责任公司 Traditional Chinese medicine for treating liver cirrhosis
CN102389482A (en) * 2011-08-14 2012-03-28 北京绿源求证科技发展有限责任公司 Traditional Chinese medicine for treating cirrhosis
CN102389461A (en) * 2011-07-30 2012-03-28 北京绿源求证科技发展有限责任公司 Traditional Chinese medicine for treating cirrhosis

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CN101843773A (en) * 2009-10-22 2010-09-29 北京绿源求证科技发展有限责任公司 Chinese medicament for treating liver cirrhosis

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Publication number Priority date Publication date Assignee Title
CN101843773A (en) * 2009-10-22 2010-09-29 北京绿源求证科技发展有限责任公司 Chinese medicament for treating liver cirrhosis

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杨祚荣 等: "半枝莲与半边莲的鉴别", 《时珍国医国药》 *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102389461A (en) * 2011-07-30 2012-03-28 北京绿源求证科技发展有限责任公司 Traditional Chinese medicine for treating cirrhosis
CN102389482A (en) * 2011-08-14 2012-03-28 北京绿源求证科技发展有限责任公司 Traditional Chinese medicine for treating cirrhosis
CN102379923A (en) * 2011-09-03 2012-03-21 北京绿源求证科技发展有限责任公司 Traditional Chinese medicine for treating cirrhosis
CN102379924A (en) * 2011-09-27 2012-03-21 北京绿源求证科技发展有限责任公司 Traditional Chinese medicine for treating liver cirrhosis
CN102302558A (en) * 2011-10-10 2012-01-04 北京绿源求证科技发展有限责任公司 Chinese medicament for treating hepatocirrhosis

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Application publication date: 20110511