CN106074912B - Chinese medicinal preparation for treating cardiovascular and cerebrovascular diseases - Google Patents

Chinese medicinal preparation for treating cardiovascular and cerebrovascular diseases Download PDF

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CN106074912B
CN106074912B CN201610699043.2A CN201610699043A CN106074912B CN 106074912 B CN106074912 B CN 106074912B CN 201610699043 A CN201610699043 A CN 201610699043A CN 106074912 B CN106074912 B CN 106074912B
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cerebrovascular diseases
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traditional chinese
treating cardiovascular
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CN106074912A (en
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李茂坤
彭宣文
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Jingzhou Traditional Chinese Medicine Hospital
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Jingzhou Traditional Chinese Medicine Hospital
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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    • A61K36/736Prunus, e.g. plum, cherry, peach, apricot or almond
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Abstract

The invention relates to a Chinese medicinal preparation for treating cardiovascular and cerebrovascular diseases, and belongs to the technical field of Chinese herbal medicine preparations. The traditional Chinese medicine preparation for treating cardiovascular and cerebrovascular diseases is prepared from sixteen Chinese herbal medicines, and the invention utilizes the comprehensive synergistic effect of sixteen raw material medicines to treat cardiovascular and cerebrovascular diseases, has small side effect on human bodies, and does not need to be decocted by patients. Has the characteristics of simple and convenient treatment method, low price and obvious curative effect. Has good effect on preventing and treating cardiovascular and cerebrovascular diseases.

Description

Chinese medicinal preparation for treating cardiovascular and cerebrovascular diseases
Technical Field
The invention relates to a Chinese medicinal preparation for treating cardiovascular and cerebrovascular diseases, and belongs to the technical field of Chinese herbal medicine preparations.
Background
Cardiovascular and cerebrovascular diseases are common diseases seriously threatening human health, particularly common diseases for the health of middle-aged and elderly people over 50 years old, and generally refer to ischemic or hemorrhagic diseases of heart, brain and systemic tissues caused by hyperlipidemia, blood hyperviscosity, atherosclerosis, hypertension and the like. Is a common and frequently encountered disease since the China enters the elderly society. At present, most people adopt a means of reducing high blood pressure, high blood pressure and high blood pressure to prevent and treat cardiovascular and cerebrovascular diseases, but most of medicines for reducing blood pressure are used for smoothing blood paths in a vasodilatation mode. However, after long-term use of the medicine, the blood vessel tends to paralyze the medicine, and finally the medicine effect is reduced or ineffective, so that the hidden danger of cardiovascular and cerebrovascular diseases cannot be eliminated.
Disclosure of Invention
The invention aims to: provides a Chinese medicinal preparation for treating cardiovascular and cerebrovascular diseases, which is prepared from Chinese medicinal herbs, aims at the pathogenesis of cardiovascular and cerebrovascular diseases, promotes blood circulation to remove blood stasis, and invigorates qi to dredge collaterals, and achieves the purpose of treating both symptoms and root causes.
The invention realizes the purpose through the following technical scheme:
a Chinese medicinal preparation for treating cardiovascular and cerebrovascular diseases is characterized in that: the traditional Chinese medicine is prepared from the following traditional Chinese medicine raw materials in parts by weight: (Unit: gram)
Radix astragali 18-22 fructus Persicae kernel 4-8
Safflower 4-8 Dangui 4-8
Radix Paeoniae Rubra 4-8 and rhizoma Ligustici Chuanxiong 4-8
12-16 red sage root of haw 12-16
Puhuang 4-8 beef knee 6-10
Dried rehmannia root 4-8 kudzu root 8-12
4-8 parts of fructus aurantii stir-fried with bran and 4-8 parts of platycodon grandiflorum
4-8 parts of bupleurum root and 1-4 parts of licorice
The preferred weight ratio range of the traditional Chinese medicine preparation for treating cardiovascular and cerebrovascular diseases is as follows:
radix astragali 19-21 fructus Persicae 5-7
Safflower 5-7 Dangui 5-7
5-7 portions of Sichuan lovage rhizome of red peony root
13-15 portions of haw ginseng 13-15 portions
Puhuang 5-7 parts of radix achyranthis bidentatae 7-9 parts of radix achyranthis bidentatae
Dried rehmannia root, radix Puerariae (5-7 parts by weight) 9-11 parts by weight
5-7 parts of orange stem and 5-7 parts of fructus aurantii stir-fried with bran
5-7 parts of bupleurum root and 1-3 parts of licorice
The optimal weight ratio range of the traditional Chinese medicine preparation for treating cardiovascular and cerebrovascular diseases is as follows:
radix astragali 20 semen Persicae 6
Safflower 6 Dangui 6
Radix Paeoniae Rubra 6 rhizoma Ligustici Chuanxiong 6
Haw 14 Danshen 14
Puhuang 6 knee 8
Dried rehmannia root, radix rehmanniae 6 and kudzu root 10
Fructus Aurantii 6 parched with bran and radix Platycodi 6
Chaihu 6 Gancao 2
The preparation method of the traditional Chinese medicine preparation for treating cardiovascular and cerebrovascular diseases comprises the following steps:
1) respectively adding water into the astragalus, the peach kernel, the safflower, the angelica, the red paeony root, the ligusticum chuanxiong hort, the hawthorn, the salvia miltiorrhiza, the cattail pollen, the achyranthes root, the radix rehmanniae, the radix puerariae, the platycodon grandiflorum, the bran-fried fructus aurantii, the radix bupleuri and the liquorice in parts by weight, decocting for three times, wherein the first time is 1.2 hours, and the second time and the third time are respectively 1 hour, filtering, and combining the decoctions;
2) concentrating the decoction obtained by the above steps by a conventional method; cooling, adding 60% ethanol with a concentration of 60% which is twice the weight of the concentrated liquid medicine, stirring, and standing at normal temperature and pressure for 24 hours for layering;
3) taking out the supernatant in the step 2, and then recovering the ethanol by a conventional method; centrifuging the supernatant after recovering ethanol, concentrating by conventional method, cooling at normal temperature, and filtering;
4) adding 1.6-2 parts by weight of aspartame and 1.6-2 parts by weight of potassium sorbate into the mixed liquid medicine treated in the step 3; then adding essence according to the weight ratio of 100:3 and stirring; then adding 1000 ml of purified water and stirring; subpackaging the obtained liquid medicine according to the amount to obtain the finished product of the traditional Chinese medicine preparation for treating cardiovascular and cerebrovascular diseases.
The characteristics are as follows: the product is a brown yellow liquid, has light smell and slightly bitter and astringent taste, and has a little precipitate which can be shaken uniformly.
The functional indications are as follows: to replenish qi and activate blood. Preventing and treating apoplexy and coronary heart disease. And apoplexy sequelae, coronary heart disease, and hyperlipidemia due to qi deficiency and blood stasis.
The invention is based on the research and treatment principle of the traditional Chinese medicine on the pathogenesis of cardiovascular and cerebrovascular diseases, refers to the scientific research achievements of the theoretical research of modern traditional Chinese medicine, adopts a large amount of qi tonifying medicines and a small amount of blood activating medicines to be matched according to the formula of the traditional Chinese medicine theory, so that the traditional Chinese medicine has the effects of invigorating qi, activating blood and dredging collaterals, and promoting blood circulation without hurting vital qi. According to the invention, the astragalus membranaceus can greatly tonify primordial qi of spleen and stomach, so that qi and blood can be nourished, and blood stasis and collaterals can be removed; peach kernel, semen Persicae has the effects of breaking blood and promoting the circulation of qi to moisten dryness; safflower, which activates blood circulation and removes blood stasis to alleviate pain, is the principal drug in combination. Chinese angelica root, radix Angelicae sinensis is good at activating blood, nourishing blood, and removing blood stasis without damaging blood, and has the effect of activating blood and removing blood stasis with radix Paeoniae Rubra and rhizoma Ligustici Chuanxiong; the hawthorn, the salvia miltiorrhiza, the cattail pollen and the achyranthes root are used as ministerial drugs for activating blood and dredging channels, removing blood stasis and relieving pain and guiding blood downward. Radix rehmanniae and radix Puerariae have the effects of nourishing blood, benefiting yin, clearing heat and activating blood, radix Platycodi and fructus Aurantii parched with bran have the effects of ascending one and descending one, relieving chest stuffiness and promoting qi circulation, radix bupleuri has the effects of soothing liver and relieving depression, ascending up to clear yang, radix Platycodi and fructus Aurantii parched with bran are used together, and are all adjuvant drugs which are good at regulating qi and activating stagnancy to ensure that qi moves and blood moves. The radix platycodi can carry medicines to ascend and is used as a guiding drug, and the liquorice is used for coordinating the medicines and is also used as a guiding drug to combine the functions of promoting blood circulation, activating blood stasis, regulating qi and activating qi, so that various diseases are cured, and the good effect of treating both symptoms and root causes of cardiovascular and cerebrovascular diseases is achieved.
In the traditional Chinese medicine raw material components, the property and the effect of each component of traditional Chinese medicine raw material medicine are as follows:
astragalus root: sweet and warm. It enters lung and spleen meridians. To replenish qi, strengthen superficies, induce diuresis, expel pus and heal wound. Can be used for treating deficiency of spleen-stomach qi, qi and blood, and deficiency of both qi and blood.
Peach kernel: bitter and neutral. It enters heart, liver, lung and large intestine meridians. Promote blood circulation to regulate menstruation, moisten intestines to relieve constipation, and relieve cough and asthma. Can be used for treating amenorrhea, dysmenorrhea, abdominal mass, pulmonary abscess, intestinal abscess, traumatic injury, swelling and pain, and constipation due to intestinal dryness.
Safflower: pungent flavor and warm nature. It enters heart and liver meridians. Promote blood circulation to remove blood stasis, dredge meridians. Can be used for treating amenorrhea, macula dark, traumatic injury, blood stasis and swelling, fracture pain, etc.
Chinese angelica: sweet and pungent in flavor and warm in nature. It enters liver, heart and spleen meridians. Tonify blood, activate blood, regulate menstruation, alleviate pain, moisten intestines to relieve constipation. Can be used for treating blood deficiency, sallow complexion, deficiency cold, abdominal pain, rheumatism, traumatic injury, carbuncle, cellulitis, and pyocutaneous disease.
Red peony root: bitter in taste and slightly cold in nature. It enters liver meridian. Clear heat and cool blood, dissipate blood stasis and alleviate pain. Can be used for treating heat entering nutrient-blood, blood stasis, amenorrhea, traumatic injury, and liver heat.
Ligusticum wallichii: pungent and warm. It enters liver, gallbladder and pericardium meridians. Promote blood circulation and move qi, dispel wind and alleviate pain. Can be used for treating menoxenia, puerperal abdominal pain, numbness of limbs, traumatic injury, and rheumatism obstruction.
Hawthorn fruit: sour, sweet and warm. Enter spleen, stomach and liver meridians. Promote digestion, invigorate stomach, promote qi circulation and dissipate blood stasis. Can be used for treating food stagnation, dyspepsia, menorrhea, and amenorrhea.
Red sage root: bitter and slightly cold in taste. It enters heart, pericardium and liver meridians. Promote blood circulation to regulate menstruation, cool blood to cure carbuncle, nourish blood and tranquilize mind. Can be used for treating menoxenia, abdominal mass, hyperpyrexia, coma, and heart blood malnutrition.
Cattail pollen: sweet and neutral. It enters liver and pericardium meridians. Stop bleeding, resolve stasis, induce diuresis. Can be used for treating hemoptysis, epistaxis, traumatic hemorrhage, amenorrhea, stranguria with astringency and pain.
Achyranthes root: bitter, sour and neutral. It enters liver and kidney meridians. Tonify liver and kidney, strengthen tendons and bones, induce diuresis and treat stranguria. Can be used for treating amenorrhea, dysmenorrhea, traumatic injury, toothache, and hyperactivity of liver-yang.
Dried rehmannia root: sweet, bitter and cold. Enter heart, liver and kidney meridians. Clear heat and cool blood, nourish yin and generate body fluid, and can be used for yin fluid injury due to heat, internal heat and diabetes, yin injury due to fever.
Kudzu root: sweet and pungent in flavor and cool in nature. It enters lung and stomach meridians. Expelling pathogenic factors from muscles and skin, allaying fever, promoting the production of body fluid, quenching thirst, invigorating yang and relieving diarrhea. Can be used for treating exterior syndrome, diarrhea due to spleen deficiency, internal heat, diabetes, and wind-cold exterior syndrome.
Balloon flower: bitter and pungent in flavor and mild in nature. It enters lung meridian. Disperse lung qi, relieve sore throat, dispel phlegm, and expel pus. Can be used for treating cough with excessive phlegm, lung carbuncle with pus, phlegm obstruction and qi stagnation, and exogenous pathogenic factor invasion of lung.
Stir-frying fructus aurantii with bran: bitter, pungent and sour, warm. It enters spleen and stomach meridians. Regulating qi, relieving epigastric distention, activating stagnancy and relieving distension. Can be used for treating qi stagnation in chest and hypochondrium, fullness and pain, dyspepsia, and retention of phlegm and fluid; gastroptosis, proctoptosis, prolapse of the son-organs.
Bupleurum root: bitter and slightly cold in nature. It enters liver and gallbladder meridians. Disperse and abate fever, soothe the liver and relieve depression, ascend yang and lift sinking. Can be used for treating common cold, fever, stagnation of qi due to depression of the liver, discomfort of liver qi, and collapse of qi due to deficiency of qi.
Licorice root: neutral in nature and sweet in flavor, and entering heart, lung, spleen and stomach meridians. Has the functions of invigorating spleen and replenishing qi, moistening lung and arresting cough, relieving spasm and pain and moderating drug property.
Compared with the prior art, the invention has the beneficial effects that:
the traditional Chinese medicine preparation for treating cardiovascular and cerebrovascular diseases is prepared from sixteen Chinese herbal medicines, treats the cardiovascular and cerebrovascular diseases by utilizing the comprehensive synergistic effect of the sixteen raw medicines, has small side effect on a human body, and does not need to be decocted by a patient. Has the characteristics of simple and convenient treatment method, low price and obvious curative effect. Has good effect on preventing and treating cardiovascular and cerebrovascular diseases.
In order to illustrate the curative effect of the invention on treating cardiovascular and cerebrovascular diseases, the invention carries out clinical treatment observation on 100 patients, and the clinical data are as follows:
1. general data, 100 subjects with cardiovascular and cerebrovascular disease, of which 50 subjects were assigned to the observation group; 50 experimenters are inserted into a control group and take common medicaments to treat cardiovascular and cerebrovascular diseases.
2. The basis of diagnosis is as follows:
1) the relevant examination of heart and brain color Doppler ultrasound, electrocardiogram and CT film;
2) traditional Chinese medicine syndrome differentiation: deficiency of both heart and spleen, disharmony between heart and kidney, hyperactivity of heart fire, hyperactivity of liver-yang, excessive heat, qi stagnation, blood stasis, deficiency of both qi and blood, and deficiency of liver-yin and kidney-yin.
3. The evaluation standard of curative effect is as follows:
and (3) curing: various traditional Chinese and western medicine clinical symptoms are normal, and the auxiliary inspection result supports the cure;
the effect is shown: various traditional Chinese and western medicine clinical symptoms are obviously improved, and the auxiliary examination result supports the obvious effect;
the method has the following advantages: various traditional Chinese and western medicine clinical symptoms are improved, and the auxiliary examination result supports effectiveness;
and (4) invalidation: the clinical symptoms of various traditional Chinese and western medicines are not improved;
deterioration: the clinical symptoms of various traditional Chinese and western medicines are obviously worsened.
4. Tracking observation data statistical table
Figure DEST_PATH_IMAGE001
Detailed Description
The following describes embodiments of the present invention in detail:
example 1:
firstly, weighing the traditional Chinese medicine raw materials according to the following embodiments: (Unit: gram)
The preparation method of the traditional Chinese medicine preparation for treating cardiovascular and cerebrovascular diseases in the above embodiments comprises the following steps:
decocting radix astragali, semen Persicae, Carthami flos, radix Angelicae sinensis, radix Paeoniae Rubra, rhizoma Ligustici Chuanxiong, fructus crataegi, Saviae Miltiorrhizae radix, pollen Typhae, Achyranthis radix, radix rehmanniae, radix Puerariae, radix Platycodi, fructus Aurantii parched with bran, bupleuri radix, and Glycyrrhrizae radix with water for three times, respectively, 1.2 hr for the first time, 1 hr for the second time and the third time, filtering, and mixing decoctions. Concentrating the combined decoction by a conventional method; cooling, adding 60% ethanol with a concentration twice the weight of the concentrated medicinal liquid, stirring, and standing at normal temperature and pressure for 24 hr for layering. Taking out the layered supernatant, and recovering ethanol by a conventional method; centrifuging the supernatant after recovering ethanol, and concentrating by a conventional method; then adding 1.6-2 parts by weight of aspartame and 1.6-2 parts by weight of potassium sorbate; then adding essence according to the weight ratio of 100:3 and stirring; adding 1000 ml of purified water and stirring; the obtained liquid medicine is packaged according to the measurement to obtain the finished product of the traditional Chinese medicine preparation for treating cardiovascular and cerebrovascular diseases.

Claims (1)

1. A Chinese medicinal preparation for treating cardiovascular and cerebrovascular diseases is characterized in that: the traditional Chinese medicine preparation for treating cardiovascular and cerebrovascular diseases comprises the following traditional Chinese medicine raw materials: unit: g;
radix astragali 20 semen Persicae 6
Safflower 6 Dangui 6
Red peony root 6 Ligusticum chuanxiong 6
Haw 14 Danshen 14
Puhuang 6 knee 8
Dried rehmannia root, radix rehmanniae 6 and kudzu root 10
Fructus Aurantii 6 parched with bran and radix Platycodi 6
Chaihu 6 Gancao 2
The traditional Chinese medicine comprises the following raw materials: radix astragali, semen Persicae, and Carthami flos are used as principal drugs; chinese angelica, red paeony root, Szechuan lovage rhizome, hawthorn, salvia miltiorrhiza, cattail pollen, twotooth achyranthes root and the like are taken as ministerial drugs; radix rehmanniae, radix puerariae, platycodon grandiflorum, fructus aurantii immaturus stir-fried with bran and radix bupleuri are all adjuvant drugs; wherein, the balloonflower root can carry the medicine to go upwards and is also used as a guiding drug, and the licorice root is used for harmonizing the effect of other drugs in the recipe and also as a guiding drug;
the preparation method of the traditional Chinese medicine preparation for treating cardiovascular and cerebrovascular diseases comprises the following steps:
1) respectively adding water into the astragalus, the peach kernel, the safflower, the angelica, the red paeony root, the ligusticum chuanxiong hort, the hawthorn, the salvia miltiorrhiza, the cattail pollen, the achyranthes root, the radix rehmanniae, the radix puerariae, the platycodon grandiflorum, the bran-fried fructus aurantii, the radix bupleuri and the liquorice in parts by weight, decocting for three times, wherein the first time is 1.2 hours, and the second time and the third time are respectively 1 hour, filtering, and combining the decoctions;
2) concentrating the decoction by a conventional method; cooling, adding 60% ethanol with a concentration of 60% which is twice the weight of the concentrated liquid medicine, stirring, and standing for 24 hours at normal temperature and normal pressure for layering;
3) taking out the supernatant in the step 2), and then recovering ethanol by a conventional method; centrifuging the supernatant after recovering ethanol, concentrating by conventional method, cooling at normal temperature, and filtering;
4) adding 1.6-2 parts by weight of aspartame and 1.6-2 parts by weight of potassium sorbate into the mixed liquid medicine treated in the step 3); then adding essence according to the weight ratio of 100:3 and stirring; then adding 1000 ml of purified water and stirring; subpackaging the obtained liquid medicine according to the amount to obtain the finished product of the traditional Chinese medicine preparation for treating cardiovascular and cerebrovascular diseases.
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