CN106074912B - Chinese medicinal preparation for treating cardiovascular and cerebrovascular diseases - Google Patents
Chinese medicinal preparation for treating cardiovascular and cerebrovascular diseases Download PDFInfo
- Publication number
- CN106074912B CN106074912B CN201610699043.2A CN201610699043A CN106074912B CN 106074912 B CN106074912 B CN 106074912B CN 201610699043 A CN201610699043 A CN 201610699043A CN 106074912 B CN106074912 B CN 106074912B
- Authority
- CN
- China
- Prior art keywords
- root
- cerebrovascular diseases
- radix
- traditional chinese
- treating cardiovascular
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 208000024172 Cardiovascular disease Diseases 0.000 title claims abstract description 31
- 208000026106 cerebrovascular disease Diseases 0.000 title claims abstract description 31
- 230000002526 effect on cardiovascular system Effects 0.000 title claims abstract description 31
- 238000002360 preparation method Methods 0.000 title claims abstract description 23
- 239000003814 drug Substances 0.000 claims abstract description 58
- 229940079593 drug Drugs 0.000 claims abstract description 19
- 230000000694 effects Effects 0.000 claims abstract description 19
- 239000002994 raw material Substances 0.000 claims abstract description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 18
- 238000007796 conventional method Methods 0.000 claims description 9
- 239000007788 liquid Substances 0.000 claims description 9
- 238000003756 stirring Methods 0.000 claims description 9
- 244000020518 Carthamus tinctorius Species 0.000 claims description 8
- 235000003255 Carthamus tinctorius Nutrition 0.000 claims description 8
- 244000303040 Glycyrrhiza glabra Species 0.000 claims description 7
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 claims description 7
- 239000009636 Huang Qi Substances 0.000 claims description 6
- 244000170916 Paeonia officinalis Species 0.000 claims description 6
- 235000006484 Paeonia officinalis Nutrition 0.000 claims description 6
- 235000006753 Platycodon grandiflorum Nutrition 0.000 claims description 6
- 240000003582 Platycodon grandiflorus Species 0.000 claims description 6
- 244000132619 red sage Species 0.000 claims description 6
- 239000006228 supernatant Substances 0.000 claims description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- 241000427159 Achyranthes Species 0.000 claims description 5
- 235000009917 Crataegus X brevipes Nutrition 0.000 claims description 5
- 235000013204 Crataegus X haemacarpa Nutrition 0.000 claims description 5
- 235000009685 Crataegus X maligna Nutrition 0.000 claims description 5
- 235000009444 Crataegus X rubrocarnea Nutrition 0.000 claims description 5
- 235000009486 Crataegus bullatus Nutrition 0.000 claims description 5
- 235000017181 Crataegus chrysocarpa Nutrition 0.000 claims description 5
- 235000009682 Crataegus limnophila Nutrition 0.000 claims description 5
- 240000000171 Crataegus monogyna Species 0.000 claims description 5
- 235000004423 Crataegus monogyna Nutrition 0.000 claims description 5
- 235000002313 Crataegus paludosa Nutrition 0.000 claims description 5
- 235000009840 Crataegus x incaedua Nutrition 0.000 claims description 5
- 241000405414 Rehmannia Species 0.000 claims description 5
- 238000001816 cooling Methods 0.000 claims description 5
- 238000001914 filtration Methods 0.000 claims description 5
- 210000000582 semen Anatomy 0.000 claims description 5
- 241000244365 Ligusticum sinense Species 0.000 claims description 4
- 235000006040 Prunus persica var persica Nutrition 0.000 claims description 4
- 244000046146 Pueraria lobata Species 0.000 claims description 4
- 235000010575 Pueraria lobata Nutrition 0.000 claims description 4
- 235000011135 Salvia miltiorrhiza Nutrition 0.000 claims description 4
- 240000000260 Typha latifolia Species 0.000 claims description 4
- 239000000047 product Substances 0.000 claims description 4
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 claims description 3
- 244000144730 Amygdalus persica Species 0.000 claims description 3
- 241000213006 Angelica dahurica Species 0.000 claims description 3
- 108010011485 Aspartame Proteins 0.000 claims description 3
- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 claims description 3
- 229960003438 aspartame Drugs 0.000 claims description 3
- 235000010357 aspartame Nutrition 0.000 claims description 3
- 239000000605 aspartame Substances 0.000 claims description 3
- 235000006533 astragalus Nutrition 0.000 claims description 3
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 claims description 3
- 210000003127 knee Anatomy 0.000 claims description 3
- 235000011477 liquorice Nutrition 0.000 claims description 3
- 239000004302 potassium sorbate Substances 0.000 claims description 3
- 229940069338 potassium sorbate Drugs 0.000 claims description 3
- 235000010241 potassium sorbate Nutrition 0.000 claims description 3
- 239000008213 purified water Substances 0.000 claims description 3
- WTPPRJKFRFIQKT-UHFFFAOYSA-N 1,6-dimethyl-8,9-dihydronaphtho[1,2-g][1]benzofuran-10,11-dione;1-methyl-6-methylidene-8,9-dihydro-7h-naphtho[1,2-g][1]benzofuran-10,11-dione Chemical compound O=C1C(=O)C2=C3CCCC(=C)C3=CC=C2C2=C1C(C)=CO2.O=C1C(=O)C2=C3CCC=C(C)C3=CC=C2C2=C1C(C)=CO2 WTPPRJKFRFIQKT-UHFFFAOYSA-N 0.000 claims description 2
- 244000061520 Angelica archangelica Species 0.000 claims description 2
- 241001061264 Astragalus Species 0.000 claims description 2
- 241000628997 Flos Species 0.000 claims description 2
- 235000001287 Guettarda speciosa Nutrition 0.000 claims description 2
- 235000017443 Hedysarum boreale Nutrition 0.000 claims description 2
- 235000007858 Hedysarum occidentale Nutrition 0.000 claims description 2
- 239000002671 adjuvant Substances 0.000 claims description 2
- 239000001947 glycyrrhiza glabra rhizome/root Substances 0.000 claims description 2
- 210000004233 talus Anatomy 0.000 claims description 2
- 241000212322 Levisticum officinale Species 0.000 claims 1
- 239000010135 fructus aurantii immaturus Substances 0.000 claims 1
- 239000001645 levisticum officinale Substances 0.000 claims 1
- 241000411851 herbal medicine Species 0.000 abstract description 4
- 238000000034 method Methods 0.000 abstract description 3
- 230000002195 synergetic effect Effects 0.000 abstract description 2
- 230000009982 effect on human Effects 0.000 abstract 1
- 239000008280 blood Substances 0.000 description 42
- 210000004369 blood Anatomy 0.000 description 41
- 210000004185 liver Anatomy 0.000 description 17
- 210000002216 heart Anatomy 0.000 description 12
- 230000003213 activating effect Effects 0.000 description 10
- 230000007812 deficiency Effects 0.000 description 10
- 208000002193 Pain Diseases 0.000 description 9
- 210000004072 lung Anatomy 0.000 description 9
- 230000036407 pain Effects 0.000 description 9
- 210000000952 spleen Anatomy 0.000 description 9
- 230000017531 blood circulation Effects 0.000 description 8
- 208000014674 injury Diseases 0.000 description 8
- 235000009508 confectionery Nutrition 0.000 description 7
- 208000024891 symptom Diseases 0.000 description 7
- 201000000736 Amenorrhea Diseases 0.000 description 6
- 206010001928 Amenorrhoea Diseases 0.000 description 6
- 231100000540 amenorrhea Toxicity 0.000 description 6
- 210000002784 stomach Anatomy 0.000 description 6
- 230000008736 traumatic injury Effects 0.000 description 6
- 201000010099 disease Diseases 0.000 description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
- 239000000796 flavoring agent Substances 0.000 description 5
- 235000019634 flavors Nutrition 0.000 description 5
- 230000001737 promoting effect Effects 0.000 description 5
- 206010020772 Hypertension Diseases 0.000 description 4
- 206010062717 Increased upper airway secretion Diseases 0.000 description 4
- 206010037660 Pyrexia Diseases 0.000 description 4
- 210000003734 kidney Anatomy 0.000 description 4
- 230000007935 neutral effect Effects 0.000 description 4
- 208000026435 phlegm Diseases 0.000 description 4
- 241000202726 Bupleurum Species 0.000 description 3
- 206010007247 Carbuncle Diseases 0.000 description 3
- 206010010774 Constipation Diseases 0.000 description 3
- 206010011224 Cough Diseases 0.000 description 3
- 208000004880 Polyuria Diseases 0.000 description 3
- 208000033809 Suppuration Diseases 0.000 description 3
- 208000027418 Wounds and injury Diseases 0.000 description 3
- 230000004087 circulation Effects 0.000 description 3
- 230000035619 diuresis Effects 0.000 description 3
- 208000013403 hyperactivity Diseases 0.000 description 3
- 230000005906 menstruation Effects 0.000 description 3
- 210000003516 pericardium Anatomy 0.000 description 3
- 230000001105 regulatory effect Effects 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 208000011580 syndromic disease Diseases 0.000 description 3
- 208000004998 Abdominal Pain Diseases 0.000 description 2
- 206010000077 Abdominal mass Diseases 0.000 description 2
- 206010008190 Cerebrovascular accident Diseases 0.000 description 2
- 206010012735 Diarrhoea Diseases 0.000 description 2
- 208000005171 Dysmenorrhea Diseases 0.000 description 2
- 206010013935 Dysmenorrhoea Diseases 0.000 description 2
- 235000001453 Glycyrrhiza echinata Nutrition 0.000 description 2
- 235000017382 Glycyrrhiza lepidota Nutrition 0.000 description 2
- 208000031226 Hyperlipidaemia Diseases 0.000 description 2
- 208000019255 Menstrual disease Diseases 0.000 description 2
- 240000007164 Salvia officinalis Species 0.000 description 2
- 208000006011 Stroke Diseases 0.000 description 2
- 206010042674 Swelling Diseases 0.000 description 2
- 230000001174 ascending effect Effects 0.000 description 2
- 235000019606 astringent taste Nutrition 0.000 description 2
- 210000001124 body fluid Anatomy 0.000 description 2
- 239000010839 body fluid Substances 0.000 description 2
- 210000004556 brain Anatomy 0.000 description 2
- 208000029078 coronary artery disease Diseases 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 206010012601 diabetes mellitus Diseases 0.000 description 2
- 201000006549 dyspepsia Diseases 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 210000000232 gallbladder Anatomy 0.000 description 2
- 230000000968 intestinal effect Effects 0.000 description 2
- 210000000936 intestine Anatomy 0.000 description 2
- 229940010454 licorice Drugs 0.000 description 2
- 230000008506 pathogenesis Effects 0.000 description 2
- 230000001717 pathogenic effect Effects 0.000 description 2
- 235000005412 red sage Nutrition 0.000 description 2
- 230000008961 swelling Effects 0.000 description 2
- 235000019640 taste Nutrition 0.000 description 2
- 229940126680 traditional chinese medicines Drugs 0.000 description 2
- 229940126673 western medicines Drugs 0.000 description 2
- LQIAZOCLNBBZQK-UHFFFAOYSA-N 1-(1,2-Diphosphanylethyl)pyrrolidin-2-one Chemical compound PCC(P)N1CCCC1=O LQIAZOCLNBBZQK-UHFFFAOYSA-N 0.000 description 1
- 206010000060 Abdominal distension Diseases 0.000 description 1
- 241000045403 Astragalus propinquus Species 0.000 description 1
- 201000001320 Atherosclerosis Diseases 0.000 description 1
- 206010007882 Cellulitis Diseases 0.000 description 1
- 206010010071 Coma Diseases 0.000 description 1
- 206010072132 Fracture pain Diseases 0.000 description 1
- 206010018045 Gastroptosis Diseases 0.000 description 1
- 208000000616 Hemoptysis Diseases 0.000 description 1
- 208000032843 Hemorrhage Diseases 0.000 description 1
- 206010020741 Hyperpyrexia Diseases 0.000 description 1
- 241000112528 Ligusticum striatum Species 0.000 description 1
- 206010025421 Macule Diseases 0.000 description 1
- 208000002720 Malnutrition Diseases 0.000 description 1
- 206010068319 Oropharyngeal pain Diseases 0.000 description 1
- 240000004371 Panax ginseng Species 0.000 description 1
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 1
- 235000003140 Panax quinquefolius Nutrition 0.000 description 1
- 201000007100 Pharyngitis Diseases 0.000 description 1
- 208000012287 Prolapse Diseases 0.000 description 1
- 240000005809 Prunus persica Species 0.000 description 1
- 208000005392 Spasm Diseases 0.000 description 1
- 206010053476 Traumatic haemorrhage Diseases 0.000 description 1
- 244000134857 Typha capensis Species 0.000 description 1
- 206010047141 Vasodilatation Diseases 0.000 description 1
- 206010000269 abscess Diseases 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 229940107666 astragalus root Drugs 0.000 description 1
- 235000015278 beef Nutrition 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 235000019658 bitter taste Nutrition 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 208000001780 epistaxis Diseases 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 235000008434 ginseng Nutrition 0.000 description 1
- 238000009499 grossing Methods 0.000 description 1
- 208000031169 hemorrhagic disease Diseases 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
- 208000034783 hypoesthesia Diseases 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 230000009545 invasion Effects 0.000 description 1
- 208000023589 ischemic disease Diseases 0.000 description 1
- 230000000302 ischemic effect Effects 0.000 description 1
- 210000002429 large intestine Anatomy 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 201000003453 lung abscess Diseases 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 230000001071 malnutrition Effects 0.000 description 1
- 235000000824 malnutrition Nutrition 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 201000009240 nasopharyngitis Diseases 0.000 description 1
- 208000015380 nutritional deficiency disease Diseases 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000010791 quenching Methods 0.000 description 1
- 230000000171 quenching effect Effects 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 210000002435 tendon Anatomy 0.000 description 1
- 230000035922 thirst Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 208000004371 toothache Diseases 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
- 230000024883 vasodilation Effects 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/233—Bupleurum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/286—Carthamus (distaff thistle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
- A61K36/346—Platycodon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/488—Pueraria (kudzu)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/734—Crataegus (hawthorn)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to a Chinese medicinal preparation for treating cardiovascular and cerebrovascular diseases, and belongs to the technical field of Chinese herbal medicine preparations. The traditional Chinese medicine preparation for treating cardiovascular and cerebrovascular diseases is prepared from sixteen Chinese herbal medicines, and the invention utilizes the comprehensive synergistic effect of sixteen raw material medicines to treat cardiovascular and cerebrovascular diseases, has small side effect on human bodies, and does not need to be decocted by patients. Has the characteristics of simple and convenient treatment method, low price and obvious curative effect. Has good effect on preventing and treating cardiovascular and cerebrovascular diseases.
Description
Technical Field
The invention relates to a Chinese medicinal preparation for treating cardiovascular and cerebrovascular diseases, and belongs to the technical field of Chinese herbal medicine preparations.
Background
Cardiovascular and cerebrovascular diseases are common diseases seriously threatening human health, particularly common diseases for the health of middle-aged and elderly people over 50 years old, and generally refer to ischemic or hemorrhagic diseases of heart, brain and systemic tissues caused by hyperlipidemia, blood hyperviscosity, atherosclerosis, hypertension and the like. Is a common and frequently encountered disease since the China enters the elderly society. At present, most people adopt a means of reducing high blood pressure, high blood pressure and high blood pressure to prevent and treat cardiovascular and cerebrovascular diseases, but most of medicines for reducing blood pressure are used for smoothing blood paths in a vasodilatation mode. However, after long-term use of the medicine, the blood vessel tends to paralyze the medicine, and finally the medicine effect is reduced or ineffective, so that the hidden danger of cardiovascular and cerebrovascular diseases cannot be eliminated.
Disclosure of Invention
The invention aims to: provides a Chinese medicinal preparation for treating cardiovascular and cerebrovascular diseases, which is prepared from Chinese medicinal herbs, aims at the pathogenesis of cardiovascular and cerebrovascular diseases, promotes blood circulation to remove blood stasis, and invigorates qi to dredge collaterals, and achieves the purpose of treating both symptoms and root causes.
The invention realizes the purpose through the following technical scheme:
a Chinese medicinal preparation for treating cardiovascular and cerebrovascular diseases is characterized in that: the traditional Chinese medicine is prepared from the following traditional Chinese medicine raw materials in parts by weight: (Unit: gram)
Radix astragali 18-22 fructus Persicae kernel 4-8
Safflower 4-8 Dangui 4-8
Radix Paeoniae Rubra 4-8 and rhizoma Ligustici Chuanxiong 4-8
12-16 red sage root of haw 12-16
Puhuang 4-8 beef knee 6-10
Dried rehmannia root 4-8 kudzu root 8-12
4-8 parts of fructus aurantii stir-fried with bran and 4-8 parts of platycodon grandiflorum
4-8 parts of bupleurum root and 1-4 parts of licorice
The preferred weight ratio range of the traditional Chinese medicine preparation for treating cardiovascular and cerebrovascular diseases is as follows:
radix astragali 19-21 fructus Persicae 5-7
Safflower 5-7 Dangui 5-7
5-7 portions of Sichuan lovage rhizome of red peony root
13-15 portions of haw ginseng 13-15 portions
Puhuang 5-7 parts of radix achyranthis bidentatae 7-9 parts of radix achyranthis bidentatae
Dried rehmannia root, radix Puerariae (5-7 parts by weight) 9-11 parts by weight
5-7 parts of orange stem and 5-7 parts of fructus aurantii stir-fried with bran
5-7 parts of bupleurum root and 1-3 parts of licorice
The optimal weight ratio range of the traditional Chinese medicine preparation for treating cardiovascular and cerebrovascular diseases is as follows:
radix astragali 20 semen Persicae 6
Safflower 6 Dangui 6
Radix Paeoniae Rubra 6 rhizoma Ligustici Chuanxiong 6
Haw 14 Danshen 14
Puhuang 6 knee 8
Dried rehmannia root, radix rehmanniae 6 and kudzu root 10
Fructus Aurantii 6 parched with bran and radix Platycodi 6
Chaihu 6 Gancao 2
The preparation method of the traditional Chinese medicine preparation for treating cardiovascular and cerebrovascular diseases comprises the following steps:
1) respectively adding water into the astragalus, the peach kernel, the safflower, the angelica, the red paeony root, the ligusticum chuanxiong hort, the hawthorn, the salvia miltiorrhiza, the cattail pollen, the achyranthes root, the radix rehmanniae, the radix puerariae, the platycodon grandiflorum, the bran-fried fructus aurantii, the radix bupleuri and the liquorice in parts by weight, decocting for three times, wherein the first time is 1.2 hours, and the second time and the third time are respectively 1 hour, filtering, and combining the decoctions;
2) concentrating the decoction obtained by the above steps by a conventional method; cooling, adding 60% ethanol with a concentration of 60% which is twice the weight of the concentrated liquid medicine, stirring, and standing at normal temperature and pressure for 24 hours for layering;
3) taking out the supernatant in the step 2, and then recovering the ethanol by a conventional method; centrifuging the supernatant after recovering ethanol, concentrating by conventional method, cooling at normal temperature, and filtering;
4) adding 1.6-2 parts by weight of aspartame and 1.6-2 parts by weight of potassium sorbate into the mixed liquid medicine treated in the step 3; then adding essence according to the weight ratio of 100:3 and stirring; then adding 1000 ml of purified water and stirring; subpackaging the obtained liquid medicine according to the amount to obtain the finished product of the traditional Chinese medicine preparation for treating cardiovascular and cerebrovascular diseases.
The characteristics are as follows: the product is a brown yellow liquid, has light smell and slightly bitter and astringent taste, and has a little precipitate which can be shaken uniformly.
The functional indications are as follows: to replenish qi and activate blood. Preventing and treating apoplexy and coronary heart disease. And apoplexy sequelae, coronary heart disease, and hyperlipidemia due to qi deficiency and blood stasis.
The invention is based on the research and treatment principle of the traditional Chinese medicine on the pathogenesis of cardiovascular and cerebrovascular diseases, refers to the scientific research achievements of the theoretical research of modern traditional Chinese medicine, adopts a large amount of qi tonifying medicines and a small amount of blood activating medicines to be matched according to the formula of the traditional Chinese medicine theory, so that the traditional Chinese medicine has the effects of invigorating qi, activating blood and dredging collaterals, and promoting blood circulation without hurting vital qi. According to the invention, the astragalus membranaceus can greatly tonify primordial qi of spleen and stomach, so that qi and blood can be nourished, and blood stasis and collaterals can be removed; peach kernel, semen Persicae has the effects of breaking blood and promoting the circulation of qi to moisten dryness; safflower, which activates blood circulation and removes blood stasis to alleviate pain, is the principal drug in combination. Chinese angelica root, radix Angelicae sinensis is good at activating blood, nourishing blood, and removing blood stasis without damaging blood, and has the effect of activating blood and removing blood stasis with radix Paeoniae Rubra and rhizoma Ligustici Chuanxiong; the hawthorn, the salvia miltiorrhiza, the cattail pollen and the achyranthes root are used as ministerial drugs for activating blood and dredging channels, removing blood stasis and relieving pain and guiding blood downward. Radix rehmanniae and radix Puerariae have the effects of nourishing blood, benefiting yin, clearing heat and activating blood, radix Platycodi and fructus Aurantii parched with bran have the effects of ascending one and descending one, relieving chest stuffiness and promoting qi circulation, radix bupleuri has the effects of soothing liver and relieving depression, ascending up to clear yang, radix Platycodi and fructus Aurantii parched with bran are used together, and are all adjuvant drugs which are good at regulating qi and activating stagnancy to ensure that qi moves and blood moves. The radix platycodi can carry medicines to ascend and is used as a guiding drug, and the liquorice is used for coordinating the medicines and is also used as a guiding drug to combine the functions of promoting blood circulation, activating blood stasis, regulating qi and activating qi, so that various diseases are cured, and the good effect of treating both symptoms and root causes of cardiovascular and cerebrovascular diseases is achieved.
In the traditional Chinese medicine raw material components, the property and the effect of each component of traditional Chinese medicine raw material medicine are as follows:
astragalus root: sweet and warm. It enters lung and spleen meridians. To replenish qi, strengthen superficies, induce diuresis, expel pus and heal wound. Can be used for treating deficiency of spleen-stomach qi, qi and blood, and deficiency of both qi and blood.
Peach kernel: bitter and neutral. It enters heart, liver, lung and large intestine meridians. Promote blood circulation to regulate menstruation, moisten intestines to relieve constipation, and relieve cough and asthma. Can be used for treating amenorrhea, dysmenorrhea, abdominal mass, pulmonary abscess, intestinal abscess, traumatic injury, swelling and pain, and constipation due to intestinal dryness.
Safflower: pungent flavor and warm nature. It enters heart and liver meridians. Promote blood circulation to remove blood stasis, dredge meridians. Can be used for treating amenorrhea, macula dark, traumatic injury, blood stasis and swelling, fracture pain, etc.
Chinese angelica: sweet and pungent in flavor and warm in nature. It enters liver, heart and spleen meridians. Tonify blood, activate blood, regulate menstruation, alleviate pain, moisten intestines to relieve constipation. Can be used for treating blood deficiency, sallow complexion, deficiency cold, abdominal pain, rheumatism, traumatic injury, carbuncle, cellulitis, and pyocutaneous disease.
Red peony root: bitter in taste and slightly cold in nature. It enters liver meridian. Clear heat and cool blood, dissipate blood stasis and alleviate pain. Can be used for treating heat entering nutrient-blood, blood stasis, amenorrhea, traumatic injury, and liver heat.
Ligusticum wallichii: pungent and warm. It enters liver, gallbladder and pericardium meridians. Promote blood circulation and move qi, dispel wind and alleviate pain. Can be used for treating menoxenia, puerperal abdominal pain, numbness of limbs, traumatic injury, and rheumatism obstruction.
Hawthorn fruit: sour, sweet and warm. Enter spleen, stomach and liver meridians. Promote digestion, invigorate stomach, promote qi circulation and dissipate blood stasis. Can be used for treating food stagnation, dyspepsia, menorrhea, and amenorrhea.
Red sage root: bitter and slightly cold in taste. It enters heart, pericardium and liver meridians. Promote blood circulation to regulate menstruation, cool blood to cure carbuncle, nourish blood and tranquilize mind. Can be used for treating menoxenia, abdominal mass, hyperpyrexia, coma, and heart blood malnutrition.
Cattail pollen: sweet and neutral. It enters liver and pericardium meridians. Stop bleeding, resolve stasis, induce diuresis. Can be used for treating hemoptysis, epistaxis, traumatic hemorrhage, amenorrhea, stranguria with astringency and pain.
Achyranthes root: bitter, sour and neutral. It enters liver and kidney meridians. Tonify liver and kidney, strengthen tendons and bones, induce diuresis and treat stranguria. Can be used for treating amenorrhea, dysmenorrhea, traumatic injury, toothache, and hyperactivity of liver-yang.
Dried rehmannia root: sweet, bitter and cold. Enter heart, liver and kidney meridians. Clear heat and cool blood, nourish yin and generate body fluid, and can be used for yin fluid injury due to heat, internal heat and diabetes, yin injury due to fever.
Kudzu root: sweet and pungent in flavor and cool in nature. It enters lung and stomach meridians. Expelling pathogenic factors from muscles and skin, allaying fever, promoting the production of body fluid, quenching thirst, invigorating yang and relieving diarrhea. Can be used for treating exterior syndrome, diarrhea due to spleen deficiency, internal heat, diabetes, and wind-cold exterior syndrome.
Balloon flower: bitter and pungent in flavor and mild in nature. It enters lung meridian. Disperse lung qi, relieve sore throat, dispel phlegm, and expel pus. Can be used for treating cough with excessive phlegm, lung carbuncle with pus, phlegm obstruction and qi stagnation, and exogenous pathogenic factor invasion of lung.
Stir-frying fructus aurantii with bran: bitter, pungent and sour, warm. It enters spleen and stomach meridians. Regulating qi, relieving epigastric distention, activating stagnancy and relieving distension. Can be used for treating qi stagnation in chest and hypochondrium, fullness and pain, dyspepsia, and retention of phlegm and fluid; gastroptosis, proctoptosis, prolapse of the son-organs.
Bupleurum root: bitter and slightly cold in nature. It enters liver and gallbladder meridians. Disperse and abate fever, soothe the liver and relieve depression, ascend yang and lift sinking. Can be used for treating common cold, fever, stagnation of qi due to depression of the liver, discomfort of liver qi, and collapse of qi due to deficiency of qi.
Licorice root: neutral in nature and sweet in flavor, and entering heart, lung, spleen and stomach meridians. Has the functions of invigorating spleen and replenishing qi, moistening lung and arresting cough, relieving spasm and pain and moderating drug property.
Compared with the prior art, the invention has the beneficial effects that:
the traditional Chinese medicine preparation for treating cardiovascular and cerebrovascular diseases is prepared from sixteen Chinese herbal medicines, treats the cardiovascular and cerebrovascular diseases by utilizing the comprehensive synergistic effect of the sixteen raw medicines, has small side effect on a human body, and does not need to be decocted by a patient. Has the characteristics of simple and convenient treatment method, low price and obvious curative effect. Has good effect on preventing and treating cardiovascular and cerebrovascular diseases.
In order to illustrate the curative effect of the invention on treating cardiovascular and cerebrovascular diseases, the invention carries out clinical treatment observation on 100 patients, and the clinical data are as follows:
1. general data, 100 subjects with cardiovascular and cerebrovascular disease, of which 50 subjects were assigned to the observation group; 50 experimenters are inserted into a control group and take common medicaments to treat cardiovascular and cerebrovascular diseases.
2. The basis of diagnosis is as follows:
1) the relevant examination of heart and brain color Doppler ultrasound, electrocardiogram and CT film;
2) traditional Chinese medicine syndrome differentiation: deficiency of both heart and spleen, disharmony between heart and kidney, hyperactivity of heart fire, hyperactivity of liver-yang, excessive heat, qi stagnation, blood stasis, deficiency of both qi and blood, and deficiency of liver-yin and kidney-yin.
3. The evaluation standard of curative effect is as follows:
and (3) curing: various traditional Chinese and western medicine clinical symptoms are normal, and the auxiliary inspection result supports the cure;
the effect is shown: various traditional Chinese and western medicine clinical symptoms are obviously improved, and the auxiliary examination result supports the obvious effect;
the method has the following advantages: various traditional Chinese and western medicine clinical symptoms are improved, and the auxiliary examination result supports effectiveness;
and (4) invalidation: the clinical symptoms of various traditional Chinese and western medicines are not improved;
deterioration: the clinical symptoms of various traditional Chinese and western medicines are obviously worsened.
4. Tracking observation data statistical table
Detailed Description
The following describes embodiments of the present invention in detail:
example 1:
firstly, weighing the traditional Chinese medicine raw materials according to the following embodiments: (Unit: gram)
The preparation method of the traditional Chinese medicine preparation for treating cardiovascular and cerebrovascular diseases in the above embodiments comprises the following steps:
decocting radix astragali, semen Persicae, Carthami flos, radix Angelicae sinensis, radix Paeoniae Rubra, rhizoma Ligustici Chuanxiong, fructus crataegi, Saviae Miltiorrhizae radix, pollen Typhae, Achyranthis radix, radix rehmanniae, radix Puerariae, radix Platycodi, fructus Aurantii parched with bran, bupleuri radix, and Glycyrrhrizae radix with water for three times, respectively, 1.2 hr for the first time, 1 hr for the second time and the third time, filtering, and mixing decoctions. Concentrating the combined decoction by a conventional method; cooling, adding 60% ethanol with a concentration twice the weight of the concentrated medicinal liquid, stirring, and standing at normal temperature and pressure for 24 hr for layering. Taking out the layered supernatant, and recovering ethanol by a conventional method; centrifuging the supernatant after recovering ethanol, and concentrating by a conventional method; then adding 1.6-2 parts by weight of aspartame and 1.6-2 parts by weight of potassium sorbate; then adding essence according to the weight ratio of 100:3 and stirring; adding 1000 ml of purified water and stirring; the obtained liquid medicine is packaged according to the measurement to obtain the finished product of the traditional Chinese medicine preparation for treating cardiovascular and cerebrovascular diseases.
Claims (1)
1. A Chinese medicinal preparation for treating cardiovascular and cerebrovascular diseases is characterized in that: the traditional Chinese medicine preparation for treating cardiovascular and cerebrovascular diseases comprises the following traditional Chinese medicine raw materials: unit: g;
radix astragali 20 semen Persicae 6
Safflower 6 Dangui 6
Red peony root 6 Ligusticum chuanxiong 6
Haw 14 Danshen 14
Puhuang 6 knee 8
Dried rehmannia root, radix rehmanniae 6 and kudzu root 10
Fructus Aurantii 6 parched with bran and radix Platycodi 6
Chaihu 6 Gancao 2
The traditional Chinese medicine comprises the following raw materials: radix astragali, semen Persicae, and Carthami flos are used as principal drugs; chinese angelica, red paeony root, Szechuan lovage rhizome, hawthorn, salvia miltiorrhiza, cattail pollen, twotooth achyranthes root and the like are taken as ministerial drugs; radix rehmanniae, radix puerariae, platycodon grandiflorum, fructus aurantii immaturus stir-fried with bran and radix bupleuri are all adjuvant drugs; wherein, the balloonflower root can carry the medicine to go upwards and is also used as a guiding drug, and the licorice root is used for harmonizing the effect of other drugs in the recipe and also as a guiding drug;
the preparation method of the traditional Chinese medicine preparation for treating cardiovascular and cerebrovascular diseases comprises the following steps:
1) respectively adding water into the astragalus, the peach kernel, the safflower, the angelica, the red paeony root, the ligusticum chuanxiong hort, the hawthorn, the salvia miltiorrhiza, the cattail pollen, the achyranthes root, the radix rehmanniae, the radix puerariae, the platycodon grandiflorum, the bran-fried fructus aurantii, the radix bupleuri and the liquorice in parts by weight, decocting for three times, wherein the first time is 1.2 hours, and the second time and the third time are respectively 1 hour, filtering, and combining the decoctions;
2) concentrating the decoction by a conventional method; cooling, adding 60% ethanol with a concentration of 60% which is twice the weight of the concentrated liquid medicine, stirring, and standing for 24 hours at normal temperature and normal pressure for layering;
3) taking out the supernatant in the step 2), and then recovering ethanol by a conventional method; centrifuging the supernatant after recovering ethanol, concentrating by conventional method, cooling at normal temperature, and filtering;
4) adding 1.6-2 parts by weight of aspartame and 1.6-2 parts by weight of potassium sorbate into the mixed liquid medicine treated in the step 3); then adding essence according to the weight ratio of 100:3 and stirring; then adding 1000 ml of purified water and stirring; subpackaging the obtained liquid medicine according to the amount to obtain the finished product of the traditional Chinese medicine preparation for treating cardiovascular and cerebrovascular diseases.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610699043.2A CN106074912B (en) | 2016-08-22 | 2016-08-22 | Chinese medicinal preparation for treating cardiovascular and cerebrovascular diseases |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610699043.2A CN106074912B (en) | 2016-08-22 | 2016-08-22 | Chinese medicinal preparation for treating cardiovascular and cerebrovascular diseases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN106074912A CN106074912A (en) | 2016-11-09 |
| CN106074912B true CN106074912B (en) | 2020-01-24 |
Family
ID=58070225
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610699043.2A Active CN106074912B (en) | 2016-08-22 | 2016-08-22 | Chinese medicinal preparation for treating cardiovascular and cerebrovascular diseases |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106074912B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107648422A (en) * | 2017-08-25 | 2018-02-02 | 刘志聪 | A kind of Chinese medicine with blood circulation invigorating efficacies |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104606513A (en) * | 2015-02-11 | 2015-05-13 | 青岛市市立医院 | Traditional Chinese medicine for treating cardiovascular and cerebrovascular diseases and preparation method of traditional Chinese medicine |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1047527C (en) * | 1993-06-24 | 1999-12-22 | 乐清健生保健品有限公司 | Chinese herb medicine instant granule for preventing and curing cardiovascular and cerebrovascular diseases |
| CN1465386A (en) * | 2002-06-24 | 2004-01-07 | 李兆红 | Chinese medicine preparation for treating cardio-cerebral vascular disease |
| CN102335380A (en) * | 2010-07-20 | 2012-02-01 | 戴海清 | Drug for treating cardiovascular and cerebrovascular diseases, and preparation method thereof |
-
2016
- 2016-08-22 CN CN201610699043.2A patent/CN106074912B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104606513A (en) * | 2015-02-11 | 2015-05-13 | 青岛市市立医院 | Traditional Chinese medicine for treating cardiovascular and cerebrovascular diseases and preparation method of traditional Chinese medicine |
Also Published As
| Publication number | Publication date |
|---|---|
| CN106074912A (en) | 2016-11-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1330347C (en) | Gongbu ointment | |
| CN104940740A (en) | Traditional Chinese medicine composition for treating polycystic ovarian syndrome and preparation method thereof | |
| CN103736018A (en) | Medicine for treating gallstones and preparation method thereof | |
| CN103599496B (en) | Traditional Chinese medicine for treatment of chronic gastritis | |
| CN104127756A (en) | Spleen invigorating anti-diarrheal paste | |
| CN104306540B (en) | A kind of treat Chinese medicine preparation of numb limbs and tense tendons and preparation method thereof after brain tumor surgery | |
| CN103272143A (en) | Traditional Chinese medicine composition for treating acne | |
| CN108653434A (en) | A kind of pharmaceutical composition for treating spleen emptiness and wet sputum type Stein-Leventhal syndrome | |
| CN104623362A (en) | Traditional Chinese medicine composition for treating depression | |
| CN104225166A (en) | Chinese medicine composition for treating amenorrhea and preparation method thereof | |
| CN106074912B (en) | Chinese medicinal preparation for treating cardiovascular and cerebrovascular diseases | |
| CN104984296A (en) | Pharmaceutical composition for treating female climacteric syndrome and preparation method thereof | |
| CN105126020A (en) | Traditional Chinese medicine for treating puerperal galactorrhea with syndrome of liver depression transforming into fire | |
| CN103156943B (en) | Medicament for treating infertility of obstructive uterine tube | |
| CN105362630A (en) | Climacteric syndrome treatment pharmaceutical composition and preparation method thereof | |
| CN104173933A (en) | Traditional Chinese medicine composition for treating depressive disorder | |
| CN104367984A (en) | Traditional Chinese medicine formula for treating aged coronary heart disease | |
| CN103550548A (en) | Traditional Chinese medicinal composition for treating constipation | |
| CN102166303B (en) | Chinese medicinal composition for treating chronic atrophic gastritis | |
| CN103156979B (en) | A kind of dispelling speckles and whitening face medicine | |
| CN102423367B (en) | Beautifying and blood-activating medicament | |
| CN101985027A (en) | Chinese herbal medicine for treating liver cirrhosis | |
| CN105395883A (en) | Traditional Chinese medicine for curing anemia | |
| CN105267862A (en) | Traditional Chinese medicine composition for treating ventricular premature beat | |
| CN104888182A (en) | Traditional Chinese medicine preparation for treating postpartum abdominal pain and preparation method therefor |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |