CN103156979B - A kind of dispelling speckles and whitening face medicine - Google Patents
A kind of dispelling speckles and whitening face medicine Download PDFInfo
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- CN103156979B CN103156979B CN201310065585.0A CN201310065585A CN103156979B CN 103156979 B CN103156979 B CN 103156979B CN 201310065585 A CN201310065585 A CN 201310065585A CN 103156979 B CN103156979 B CN 103156979B
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Abstract
The invention provides a kind of dispelling speckles and whitening face medicine, be made up of the component of following masses part: Radix Angelicae Sinensis 10 ~ 20 parts, the Radix Paeoniae Alba 9 ~ 15 parts, Rhizoma Dioscoreae 12 ~ 22 parts, 12 ~ 22 parts, Poria, 9 ~ 15 parts, Flos Carthami, 9 ~ 15 parts, Semen Persicae, Radix Bupleuri 9 ~ 15 parts, Cortex Moutan 9 ~ 15 parts, 24 ~ 34 parts, the Radix Rehmanniae, Fructus Corni 12 ~ 24 parts, Rhizoma Alismatis 9 ~ 15 parts, Radix Arnebiae (Radix Lithospermi) 15 ~ 25 parts.There is soothing liver-QI yin nourishing, the effect of blood stasis dispelling of enriching blood; For depression of liver-QI, distending pain in the chest and hypochondrium, has a dizzy spell, loss of appetite, menoxenia, distending pain of the breast, face chloasma, the pigmentation pigment diseases such as freckle; And there is significant curative effects such as recovering soon, relapse rate is low, safety is high, have no side effect, and cost is low, and simple for production.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition---dispelling speckles and whitening face medicine, belongs to biological technical field.
Background technology
Liver controlling conveyance and dispersion, have the function of turnover QI and blood, natural disposition is just contrary to, and dislikes the change of depression, and the stimulation of any feelings will all can cause the strongly fragrant of irritability and not freely, catharsis is not normal, gently the then stagnation of QI, even QI rising in reverse order, and stagnation of QI QI rising in reverse order can cause blood stasis and blood oozing from the body openings or subcuta neous tissue.Treatment is then based on suppressing hyperactive liver for descending adverse qi.Three blood stasis, irritability stasis, can cause blood stasis.Difficult Classic is said: " liver is long-pending, and name says lump at the left hypochondrium, under left flank, as multiple cup, has cephalopodium ... "." have between skin thread red trace person, hematoma is also " that ZHU Dan-xi is mentioned, be all say cause the syndrome of the stasis of blood because of the stagnation of QI.Sign common in hepatopathy, as hepatosplenomegaly, spider angioma etc., is all the result of blood stasis, and treatment is just normal based on blood circulation promoting and blood stasis dispelling.
And modern society, people are often because work and life stress cause depression of liver-QI, the long-term stagnation of QI cause the stasis of blood and with congestion, hemorrhage, menoxenia, dysmenorrhea, depression, have a dizzy spell, the symptom such as the tired power of body, vomiting, insomnia and dreamful sleep, irritability, appetite are poor, distending pain in the chest and hypochondrium, give life, work and bring inconvenience.
Summary of the invention
Uncomfortable for what solve that the stagnation of QI causes that the stasis of blood brings, the invention provides a kind of dispelling speckles and whitening face medicine.
The invention provides so a kind of dispelling speckles and whitening face medicine, it is characterized in that being made up of the component of following masses part:
Radix Angelicae Sinensis 10 ~ 20 parts
The Radix Paeoniae Alba 9 ~ 15 parts
Rhizoma Dioscoreae 12 ~ 22 parts
12 ~ 22 parts, Poria
9 ~ 15 parts, Flos Carthami
9 ~ 15 parts, Semen Persicae
Radix Bupleuri 9 ~ 15 parts
Cortex Moutan 9 ~ 15 parts
24 ~ 34 parts, the Radix Rehmanniae
Fructus Corni 12 ~ 24 parts
Rhizoma Alismatis 9 ~ 15 parts
Radix Arnebiae (Radix Lithospermi) 15 ~ 25 parts.
Wherein, the nature and flavor of Radix Angelicae Sinensis: warm in nature, sweet in the mouth, pungent; Return liver, the heart, spleen channel; Cure mainly: enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.The nature and flavor of the Radix Paeoniae Alba: picric acid are cool; Enter liver, spleen channel; Cure mainly: nourishing blood for regulating menstruation, easing the affected liver to relieve pain, astringing YIN to stop sweating, suppressing liver-YANG.The nature and flavor of Rhizoma Dioscoreae: sweet are flat; Return spleen, lung, kidney channel; Cure mainly: spleen reinforcing nourishing the stomach, promote the production of body fluid excessive lung, the kidney invigorating arresting seminal emission.The nature and flavor of Poria: sweet, light are flat; GUIXIN warp, lung meridian, spleen channel, kidney channel; Cure mainly: promoting diuresis to eliminate damp pathogen, strengthening the spleen stomach function regulating, mind tranquilizing and the heart calming.The nature and flavor of Flos Carthami: warm in nature, acrid in the mouth, GUIXIN, Liver Channel; Cure mainly: promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain.The nature and flavor of Semen Persicae: bitter, sweet are flat; GUIXIN, liver, large intestine channel; Cure mainly: blood circulation promoting and blood stasis dispelling, loosening bowel to relieve constipation, relieving cough and asthma.The nature and flavor of Radix Bupleuri: warm in nature, acrid in the mouth; Enter liver, spleen, bladder three warp; Cure mainly: induce sweat, dispel the wind, victory is wet.The nature and flavor of Cortex Moutan: cold in nature, bitter in the mouth, cool, be slightly cold; GUIXIN, liver, kidney channel; Cure mainly: clearing away heat and cooling blood, blood circulation promoting and blood stasis dispelling.The nature and flavor of the Radix Rehmanniae: sweet, cold; GUIXIN, liver, kidney channel; Cure mainly: clearing away heat and cooling blood, yin nourishing, promote the production of body fluid.The nature and flavor of Fructus Corni: acid, puckery, tepor; Return liver, kidney channel; Cure mainly: liver and kidney tonifying, arresting collape syndrome by astringents.The nature and flavor of Rhizoma Alismatis: sweet are light, cold; Return kidney, urinary bladder channel; Cure mainly: promoting diuresis to eliminate damp pathogen, expel the heat-evil, change candle blood fat reducing.The nature and flavor of Radix Arnebiae (Radix Lithospermi): sweet, salty, cold; GUIXIN, Liver Channel; Cure mainly: clearing away heat and cooling blood, promoting blood circulation and detoxication, rash speckle removing, coordinating the actions of various ingredients in a prescription.
Each composition of the present invention is commercially available prod.
The invention provides the pharmacological action of medicine: Radix Angelicae Sinensis has the merit of enriching blood and invigorating blood circulation; The Radix Paeoniae Alba has the effect of nourishing blood to suppress the hyperactive liver; Poria has the effect of promoting diuresis to eliminate damp pathogen, mind tranquilizing and the heart calming; Flos Carthami has the merit of latus rectum of invigorating blood circulation, eliminating stasis to stop pain; Radix Bupleuri have induce sweat, wind action of dispelling; Cortex Moutan has the merit of clearing away heat and cooling blood, blood circulation promoting and blood stasis dispelling; The Radix Rehmanniae has the effect of clearing away heat and cooling blood, YIN nourishing and the production of body fluid promoting.
Dispelling speckles and whitening face medicine of the present invention, obtains through following method:
(1) get the raw materials ready by following mass parts:
Radix Angelicae Sinensis 10 ~ 20 parts
The Radix Paeoniae Alba 9 ~ 15 parts
Rhizoma Dioscoreae 12 ~ 22 parts
12 ~ 22 parts, Poria
9 ~ 15 parts, Flos Carthami
9 ~ 15 parts, Semen Persicae
Radix Bupleuri 9 ~ 15 parts
Cortex Moutan 9 ~ 15 parts
24 ~ 34 parts, the Radix Rehmanniae
Fructus Corni 12 ~ 24 parts
Rhizoma Alismatis 9 ~ 15 parts
Radix Arnebiae (Radix Lithospermi) 15 ~ 25 parts;
(2) after the Poria of step (1), Radix Arnebiae (Radix Lithospermi) being cleaned, drying and crushing, screening (crossing 80 ~ 300 orders), obtains fine powder, for subsequent use; Be 1 ︰ 4 ~ 8 by all the other ten taste medical materials by solid-liquid mass ratio, decoct with water three times, each decoction 1 ~ 3 hour, cross leaching supernatant, relative density when merging three filtrates and be condensed into 50 DEG C is the thick paste of 1.35 ~ 1.40, dry, pulverize, mix with above-mentioned fine powder, add appropriate pharmaceutic adjuvant, make the oral formulations pharmaceutically accepted according to a conventional method.
Dispelling speckles and whitening face medicine of the present invention, obtains through following method:
(1) get the raw materials ready by following mass parts:
Radix Angelicae Sinensis 10 ~ 20 parts
The Radix Paeoniae Alba 9 ~ 15 parts
Rhizoma Dioscoreae 12 ~ 22 parts
12 ~ 22 parts, Poria
9 ~ 15 parts, Flos Carthami
9 ~ 15 parts, Semen Persicae
Radix Bupleuri 9 ~ 15 parts
Cortex Moutan 9 ~ 15 parts
24 ~ 34 parts, the Radix Rehmanniae
Fructus Corni 12 ~ 24 parts
Rhizoma Alismatis 9 ~ 15 parts
Radix Arnebiae (Radix Lithospermi) 15 ~ 25 parts;
(2) by each taste medicine of step (1), after carrying out clean routinely, dry, be ground into fine powder, add appropriate pharmaceutic adjuvant, make the oral formulations pharmaceutically accepted according to a conventional method, or directly make the oral formulations pharmaceutically accepted according to a conventional method.
Described pharmaceutic adjuvant is the conventional pharmaceutical adjuvants such as starch, magnesium stearate, Mel.
The described oral formulations pharmaceutically accepted is: tablet, decoction, capsule, soft capsule, granule, pill, oral liquid.
The effect that the present invention possesses and advantage: the dispelling speckles and whitening face medicine adopting such scheme to obtain, has soothing liver-QI yin nourishing, the effect of blood stasis dispelling of enriching blood; For depression of liver-QI, distending pain in the chest and hypochondrium, has a dizzy spell, loss of appetite, menoxenia, distending pain of the breast, face chloasma, pigmentation pigment diseases such as freckle and having recover the significant curative effect such as fast, relapse rate is low, safety is high, have no side effect, and cost is low, simple for production.
Detailed description of the invention
Illustrate content of the present invention further below in conjunction with embodiment, but protection scope of the present invention is not limited in these embodiments.
Embodiment 1
(1) by following mass parts feeding:
Radix Angelicae Sinensis 10 parts, the Radix Paeoniae Alba 15 parts, Rhizoma Dioscoreae 12 parts, 22 parts, Poria, 9 parts, Flos Carthami, 15 parts, Semen Persicae, Radix Bupleuri 9 parts, Cortex Moutan 15 parts, 24 parts, the Radix Rehmanniae, Fructus Corni 24 parts, Rhizoma Alismatis 9 parts, Radix Arnebiae (Radix Lithospermi) 25 parts;
(2), after the Poria in step (1), Radix Arnebiae (Radix Lithospermi) being cleaned, dry, pulverize, cross 80 mesh sieves, obtain fine powder, for subsequent use; Be 1 ︰ 4 by all the other ten taste medical materials by solid-liquid mass ratio, decoct with water three times, each 1 hour, get supernatant, relative density when merging three filtrates and be condensed into 50 DEG C is the thick paste of 1.35 ~ 1.40, dry, pulverize, then mix with above-mentioned fine powder, add appropriate amount of starch, make tablet by conventional method of the prior art.
The Radix Paeoniae Alba is contained with peoniflorin (C in every sheet
23h
28o
11) meter, must not 1.50mg be less than.
Embodiment 2
(1) by following mass parts feeding:
Radix Angelicae Sinensis 20 parts, the Radix Paeoniae Alba 9 parts, Rhizoma Dioscoreae 22 parts, 12 parts, Poria, 15 parts, Flos Carthami, 9 parts, Semen Persicae, Radix Bupleuri 15 parts, Cortex Moutan 9 parts, 34 parts, the Radix Rehmanniae, Fructus Corni 12 parts, Rhizoma Alismatis 15 parts, Radix Arnebiae (Radix Lithospermi) 15 parts;
(2) after the Poria in step (1), Radix Arnebiae (Radix Lithospermi) being made by step (1) only, dry, pulverize, cross 300 mesh sieves, obtain fine powder, for subsequent use; Be 1 ︰ 6 by all the other ten taste medical materials by solid-liquid mass ratio, decoct with water three times, each 2 hours, get supernatant, relative density when merging three filtrates and be concentrated into 50 DEG C is the thick paste of 1.35 ~ 1.40, dry, pulverize, then mix with above-mentioned fine powder, add appropriate magnesium stearate, make electuary by conventional method of the prior art.
Embodiment 3
(1) by following mass parts feeding:
Radix Angelicae Sinensis 15 parts, the Radix Paeoniae Alba 12 parts, Rhizoma Dioscoreae 18 parts, 17 parts, Poria, 12 parts, Flos Carthami, 13 parts, Semen Persicae, Radix Bupleuri 12 parts, Cortex Moutan 13 parts, 29 parts, the Radix Rehmanniae, Fructus Corni 18 parts, Rhizoma Alismatis 12 parts, Radix Arnebiae (Radix Lithospermi) 20 parts;
(2) after the Poria in step (1), Radix Arnebiae (Radix Lithospermi) being made by step (1) only, dry, pulverize, cross 200 mesh sieves, obtain fine powder, for subsequent use; Be 1 ︰ 8 by all the other ten taste medical materials by solid-liquid mass ratio, decoct with water three times, each 3 hours, get supernatant, relative density when merging three filtrates and be condensed into 50 DEG C is the thick paste of 1.40, dry, pulverize and then mix with above-mentioned fine powder, directly make capsule by conventional method of the prior art.
Embodiment 4
(1) by following mass parts feeding:
Radix Angelicae Sinensis 20 parts, the Radix Paeoniae Alba 15 parts, Rhizoma Dioscoreae 22 parts, 22 parts, Poria, 15 parts, Flos Carthami, 15 parts, Semen Persicae, Radix Bupleuri 15 parts, Cortex Moutan 15 parts, 24 parts, the Radix Rehmanniae, Fructus Corni 24 parts, Rhizoma Alismatis 9 parts, Radix Arnebiae (Radix Lithospermi) 15 parts;
(2) by each taste medicine of step (1), after carrying out clean routinely, dry, pulverize into fine powder, add proper honey, make pill according to a conventional method.
Pharmacology's toxicologic study of the Chinese medicine composition of dispelling speckles and whitening face medicine provided by the invention:
When giving rat with 20g/kg, 10g/kg, the amount of 5g/kg, after gavaging 90 days continuously, in rat general activity, body weight, blood hemoglobin, leukocyte, erythrocyte, platelet, leukocyte differential count, blood, GPT, GOT, BUN, G are all without exception, with normal saline group there was no significant difference, its numerical value is all in normal range, the main organs such as rats'liver, spleen, lung, kidney, intestinal, brain, testis, ovary are also had no adverse effects, namely the Chinese medicine composition clinical practice of dispelling speckles and whitening face medicine safely, have no side effect.
Get above-described embodiment 1 gained dispelling speckles and whitening face medicine, treat for following clinical:
One, treatment target
The menoxenia caused because of liver qi stagnation type, distending pain of the breast, distending pain in the chest and hypochondrium 300 example, and with having a dizzy spell, inappetence, depression of liver-QI, face chloasma, the pigmentation pigment disease symptomses such as freckle, be divided into treatment group and each 150 examples of matched group, wherein chloasma 50 example, freckle 50 example, pigmentation 50 example at random.
Two, instructions of taking
Treatment group is oral, each 2 ~ 4,3 times on the one, serve on 21.
Matched group takes conventional soothing liver-QI medicine routinely, serve on 21.
Three, result:
Dispelling speckles and whitening face medicine provided by the invention, 96% is reached to the effective percentage of the menoxenia that depression of liver-QI causes, the effective percentage of distending pain of the breast reaches 93%, the effective percentage of distending pain in the chest and hypochondrium reaches 89%, the effective percentage of face chloasma reaches 95%, the effective percentage of face freckle reaches 91%, the Pigmented effective percentage of face reaches 90%, and matched group only reaches 60% to the effective percentage of the menoxenia that depression of liver-QI causes, the effective percentage of distending pain of the breast reaches 50%, the effective percentage of distending pain in the chest and hypochondrium reaches 56%, the effective percentage of face chloasma reaches, 61%, the effective percentage of face freckle reaches 52%, the Pigmented effective percentage of face reaches 55%.
Four, conclusion
The Chinese medicine composition of dispelling speckles and whitening face medicine provided by the invention is by HERBA BUPLEURI, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Rhizoma Dioscoreae, Poria, Flos Carthami, Semen Persicae, Radix Bupleuri, Cortex Moutan, the Radix Rehmanniae, Fructus Corni, Rhizoma Alismatis, Radix Arnebiae (Radix Lithospermi).Preparation and the compound preparation that obtains, to the menoxenia that liver qi stagnation type causes, distending pain in the chest and hypochondrium, there is significant curative effect, can cerebral tissue be improved, the impaired power of cardiac muscle to anoxia, also have thrombotic effect in Inhibition test animal body, matched group is better than to its effect of menoxenia.
The Chinese medicine composition of this dispelling speckles and whitening face medicine is according to Yi nationality of Yunnan traditional medicine document " sorrow jail book on Chinese herbal medicine ", on the basis of traditional Chinese medical science ancient prescription (Song " formulary of peaceful benevolent dispensary "), in conjunction with Ailaoshan mountain area Yi nationality, distributed over Yunnan, Sichuan and Guizhou folk medicine experience, through the pure natural ethnic drug that scientific composition develops, through over thousands of routine clinical verification, this Chinese medicine composition is the good medicine regulating women's endocrine, there is soothing liver-QI yin nourishing, to enrich blood effect of blood stasis dispelling, for depression of liver-QI, distending pain in the chest and hypochondrium, have a dizzy spell, loss of appetite, menoxenia, distending pain of the breast, face chloasma, the pigmentation pigment diseases such as freckle have significant curative effect, the good medicine of disease therapy.
Effective in cure good, the advantage such as application safety, toxic and side effects are little of the Chinese medicine composition of this dispelling speckles and whitening face medicine, obtained constant product quality, easy to use, be more suitable for clinical application.
Claims (3)
1. a dispelling speckles and whitening face medicine, is characterized in that Chinese medicine ingredients is wherein made up of the component of following masses part:
Radix Angelicae Sinensis 10 ~ 20 parts
The Radix Paeoniae Alba 9 ~ 15 parts
Rhizoma Dioscoreae 12 ~ 22 parts
12 ~ 22 parts, Poria
9 ~ 15 parts, Flos Carthami
9 ~ 15 parts, Semen Persicae
Radix Bupleuri 9 ~ 15 parts
Cortex Moutan 9 ~ 15 parts
24 ~ 34 parts, the Radix Rehmanniae
Fructus Corni 12 ~ 24 parts
Rhizoma Alismatis 9 ~ 15 parts
Radix Arnebiae (Radix Lithospermi) 15 ~ 25 parts.
2. prepare the method for dispelling speckles and whitening face medicine as claimed in claim 1, it is characterized in that through following each step:
(1) get the raw materials ready by following mass parts:
Radix Angelicae Sinensis 10 ~ 20 parts
The Radix Paeoniae Alba 9 ~ 15 parts
Rhizoma Dioscoreae 12 ~ 22 parts
12 ~ 22 parts, Poria
9 ~ 15 parts, Flos Carthami
9 ~ 15 parts, Semen Persicae
Radix Bupleuri 9 ~ 15 parts
Cortex Moutan 9 ~ 15 parts
24 ~ 34 parts, the Radix Rehmanniae
Fructus Corni 12 ~ 24 parts
Rhizoma Alismatis 9 ~ 15 parts
Radix Arnebiae (Radix Lithospermi) 15 ~ 25 parts;
(2), after the Poria of step (1), Radix Arnebiae (Radix Lithospermi) being cleaned, drying and crushing, is sieving through 80 ~ 300 orders, obtains fine powder, for subsequent use; Be 1 ︰ 4 ~ 8 by all the other ten taste medical materials by solid-liquid mass ratio, decoct with water three times, each decoction 1 ~ 3 hour, cross leaching supernatant, relative density when merging three filtrates and be condensed into 50 DEG C is the thick paste of 1.35 ~ 1.40, dry, pulverize, mix with above-mentioned fine powder, add appropriate pharmaceutic adjuvant, make the oral formulations pharmaceutically accepted according to a conventional method.
3. prepare the method for dispelling speckles and whitening face medicine as claimed in claim 1, it is characterized in that through following each step:
(1) get the raw materials ready by following mass parts:
Radix Angelicae Sinensis 10 ~ 20 parts
The Radix Paeoniae Alba 9 ~ 15 parts
Rhizoma Dioscoreae 12 ~ 22 parts
12 ~ 22 parts, Poria
9 ~ 15 parts, Flos Carthami
9 ~ 15 parts, Semen Persicae
Radix Bupleuri 9 ~ 15 parts
Cortex Moutan 9 ~ 15 parts
24 ~ 34 parts, the Radix Rehmanniae
Fructus Corni 12 ~ 24 parts
Rhizoma Alismatis 9 ~ 15 parts
Radix Arnebiae (Radix Lithospermi) 15 ~ 25 parts;
(2), by each taste medicine of step (1), after carrying out clean routinely, after dry, pulverize into fine powder, directly make according to a conventional method or make the oral formulations pharmaceutically accepted again after adding appropriate pharmaceutic adjuvant.
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| CN107137474A (en) * | 2017-06-09 | 2017-09-08 | 魏旭東 | A kind of freckle removal traditional Chinese medicinal composition |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101934052A (en) * | 2010-09-04 | 2011-01-05 | 魏玮 | Medicament for treating facial chloasma and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101934052A (en) * | 2010-09-04 | 2011-01-05 | 魏玮 | Medicament for treating facial chloasma and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 红花等;南京中医药大学;《中药大辞典》;上海科学技术出版社;20060331;第1067页 * |
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