CN104173773A - Preparation with functions of treating migraine, dispelling wind and promoting blood circulation and preparation methods - Google Patents
Preparation with functions of treating migraine, dispelling wind and promoting blood circulation and preparation methods Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine preparation with the functions of treating migraine, dispelling the wind and promoting blood circulation. The traditional Chinese medicine preparation is prepared from the following main raw materials in parts by weight: 25-35 parts of Indian bread, 6-12 parts of razor clam shell, 10-20 parts of Chinese angelica, 4-9 parts of tall gastrodia tuber, 8-16 parts of Sichuan lovage rhizome, 9-18 parts of white paeony root, 10-25 parts of radix bupleuri, 8-18 parts of ruddle, 12-20 parts of lotus leaves, 10-14 parts of pinellia tuber, 8-12 parts of dried tangerine peel, 10-18 parts of oriental waterplantain rhizome, 25-35 parts of fossil fragments, 22-36 parts of oyster shell, 5-15 parts of antelope's horn, 5-9 parts of liquorice, 6-12 parts of safflower, 6-15 parts of Chinese lovage, 2-6 parts of manchurian wildginger, 18-28 parts of gypsum, 8-12 parts of divaricate saposhnikovia root, 3-6 parts of scorpion, 4-6 parts of centipede, 20-40 parts of salvia miltiorrhiza, 12-22 parts of red peony root, 6-9 parts of earthworm, 3-9 parts of sea-ear shell and 5-12 parts of common selfheal fruit-spike. The traditional Chinese medicine composition provided by the invention is scientific in formulating a prescription. Preparation methods of various dosage forms are simple. The obtained products are convenient to take.
Description
Technical field
The invention discloses a kind of Chinese medicine preparation, especially migraine expelling wind and activating blood circulation Chinese medicine preparation and preparation method thereof.Belong to Chinese medicine field.
Background technology
Migraine mostly is the pulsatile headache that one or both sides temples shows effect repeatedly, before outbreak, can accompany vision, somatosensor aura, outbreak companion's vomiting often.Women is multiple, is about 3～4 times of male, and how in adolescence onset, age of onset 25～34 years old, the childhood period that minority betiding or after the middle age.The migrainous cause of disease is considered to due to the comprehensive function of environmental factors and inherited genetic factors.About 2/3rds case has the reason of inherited genetic factors.The fluctuation of hormone level may be also a factor: before adolescence, the boy who is subject to migraine impact is slightly more than young girl, but after this, the women who is subject to migraine impact will have more two to three times than male.Conventionally at phenolics, migrainous impact can weaken.The migrainous principle of accurately causing a disease is still unknown at present.But people generally believe that this is because neural blood vessel disorder causes.Main pathology is interpreted as corticocerebral excitement levels enhancing at present, and in brain stem, the neuronic pain in nuclei quintus is controlled abnormal.
Migraine mainly includes the migraine of tendency and the large class of the migraine of absence of aura two.The migraine that has tendency, also claims classical migraine, accounts for migrainously 15%～18%, has family history more.Model case pathogenic process was divided into for three phases: tendency phase, headache phase and headache later stage.The migraine of absence of aura, also claims common migraine, is modal type, accounts for migrainous 80%.With respect to the migraine that has tendency, lack typical tendency, be often all pain of bilateral temples and socket of the eye, can be pulsation, headache is outbreak repeatedly, companion's vomiting.The headache persistent period is longer, can reach a few days, and durantedolore companion cervical muscle shrinks and can make complicated symptoms.Outbreak has scalp to touch a tender spot often, and vomiting is even can make headache stop.Normal and the menstruation of this type migraine has obvious relation.Compare with migraine without aura, Migraine without aura has higher seizure frequency, can have a strong impact on patient's work and life, often needs the treatment of frequent application analgesic.Initial therapy can be used simple analgesic, as ibuprofen and acetaminophen are treated headache, and with antiemetic, treats nauseatingly, prevents vomiting.Medicaments, as Qu Putan class or Ergotamine can not selected when simple analgesic effect is good.
Publication number CN 103007027 A(application number 201210518759.X) Chinese patent literature discloses a kind of migrainous pill for the treatment of, and following component, according to parts by weight, consists of: Radix Bupleuri 5-10 part, Concha Ostreae 3-5 part, Fructus Kochiae 5-7 part, Fructus Xanthii 4-6 part, Herba Artemisiae Anomalae 3-5 part, Radix Ophiopogonis 3-5 part, Radix Saposhnikoviae 3-5 part, Herba Asari 2-8 part, Radix Notoginseng 6-9 part, Herba Aristolochiae Mollissimae 6-8 part, Spica Prunellae 7-8 part, Herba Ephedrae 1-3 part.Publication number CN 102302751A(application number 201110238307.1) Chinese patent literature discloses a kind of migrainous Chinese medicine, raw material by following parts by weight is made: Rhizoma Panacis Japonici 5-10 part, Fructus Mangifera Indicae root 3-5 part, Herba Artemisiae Anomalae 10-12 part, Herba Salomoniae Cantoniensis 4-6 part, Folium Baeckeae 4-6 part, Rhizoma Cyperi 15-20 part, Radix Saposhnikoviae 3-5 part, Radix Angelicae Sinensis 3-5 part, Herba Asari 1-3 part, Radix Angelicae Dahuricae 3-5 part, Rhizoma Et Radix Notopterygii 3-5 part, Radix Angelicae Pubescentis 3-5 part, Radix Glycyrrhizae 1-3 part, Rhizoma Atractylodis 3-5 part, Radix Ophiopogonis 3-5 part, Radix Scutellariae 4-6 part, Fructus Viticis 2-4 part, Flos Chrysanthemi 2-4 part, Rhizoma Zingiberis Recens fresh goods 6-8 part.Publication number CN 102641418 A(application numbers 201210146686.6) Chinese patent literature discloses a kind of migrainous medicament for the treatment of, and it is to be made by the material of following weight proportioning: Semen Persicae, Radix Ophiopogonis, Rhizoma Atractylodis, Semen Cassiae, Fructus Aurantii Immaturus, Radix Scutellariae, Herba Asari, Radix Platycodonis, Radix Saposhnikoviae, Semen Persicae, Pumex, Rhizoma Chuanxiong, Bulbus Lilii, Arisaema Cum Bile, the Radix Angelicae Dahuricae and Radix Morindae Officinalis.
In a word, Chinese medicine is being obtained certain effect aspect treatment primary disease, but also has some problems, migrainous Therapeutic Method is cured the symptoms, not the disease mostly now, relapse rate is higher, and some simple analgesic also has side effect, and the effect for the treatment of by Chinese herbs need to strengthen.
Summary of the invention
Not enough for prior art, the object of this invention is to provide a kind of Chinese medicine preparation of migraine expelling wind and activating blood circulation, there is feature simple to operate, evident in efficacy, and its adopts comparatively common Chinese crude drug as raw material, with low cost and have no side effect.
Technical scheme of the present invention is:
The Chinese medicine preparation of migraine expelling wind and activating blood circulation, the main raw material(s) that takes off row weight proportion is prepared from: Poria 25-35; Concha Solen gouldii 6-12; Radix Angelicae Sinensis 10-20; Rhizoma Gastrodiae 4-9; Rhizoma Chuanxiong 8-16; Radix Paeoniae Alba 9-18; Radix Bupleuri 10-25; Haematitum 8-18; Folium Nelumbinis 12-20; Rhizoma Pinelliae 10-14; Pericarpium Citri Reticulatae 8-12; Rhizoma Alismatis 10-18; Os Draconis 25-35; Concha Ostreae 22-36; Cornu Saigae Tataricae 5-15; Radix Glycyrrhizae 5-9; Flos Carthami 6-12; Rhizoma Ligustici 6-15; Herba Asari 2-6; Gypsum Fibrosum 18-28; Radix Saposhnikoviae 8-12; Scorpio 3-6; Scolopendra 4-6; Radix Salviae Miltiorrhizae 20-40; Radix Paeoniae Rubra 12-22; Pheretima 6-9; Concha Haliotidis 3-9; Spica Prunellae 5-12.
Preferred version is: Poria 29-31; Concha Solen gouldii 8-10; Radix Angelicae Sinensis 14-17; Rhizoma Gastrodiae 5-7; Rhizoma Chuanxiong 10-15; Radix Paeoniae Alba 12-15; Radix Bupleuri 15-20; Haematitum 11-15; Folium Nelumbinis 15-17; Rhizoma Pinelliae 11-13; Pericarpium Citri Reticulatae 9-11; Rhizoma Alismatis 13-15; Os Draconis 29-31; Concha Ostreae 27-31; Cornu Saigae Tataricae 9-11; Radix Glycyrrhizae 6-8; Flos Carthami 8-10; Rhizoma Ligustici 9-12; Herba Asari 3-5; Gypsum Fibrosum 22-24; Radix Saposhnikoviae 9-11; Scorpio 4-5; Scolopendra 4-5; Radix Salviae Miltiorrhizae 28-32; Radix Paeoniae Rubra 16-18; Pheretima 7-8; Concha Haliotidis 5-7; Spica Prunellae 8-9.
The scheme being more preferably is: Poria 30, Concha Solen gouldii 9, Radix Angelicae Sinensis 15, Rhizoma Gastrodiae 6.5, Rhizoma Chuanxiong 12, the Radix Paeoniae Alba 13.5, Radix Bupleuri 17.5, Haematitum 13, Folium Nelumbinis 16, the Rhizoma Pinelliae 12, Pericarpium Citri Reticulatae 10, Rhizoma Alismatis 14, Os Draconis 30, Concha Ostreae 29, Cornu Saigae Tataricae 10, Radix Glycyrrhizae 7, Flos Carthami 9, Rhizoma Ligustici 10.5, Herba Asari 4, Gypsum Fibrosum 23, Radix Saposhnikoviae 10, Scorpio 4.5, Scolopendra 5, Radix Salviae Miltiorrhizae 30, Radix Paeoniae Rubra 17, Pheretima 7.5, Concha Haliotidis 6, Spica Prunellae 8.5.
The present invention also provides above-mentioned Chinese medicine preparation has been made to pharmaceutically acceptable decoction, powder and capsule.
The preparation process of described decoction is as follows:
1. Concha Solen gouldii, Haematitum, Os Draconis, Concha Ostreae, Cornu Saigae Tataricae, Concha Haliotidis and Gypsum Fibrosum are smashed and are put into marmite, add vinegar to soak 10-20 minute (preferably 15 minutes), after decoct with water, intense fire is fried open and turns slow fire boiling 80-100 minute (preferably 90 minutes);
2. after filtering, obtain medicinal liquid, after medicinal residues continue to decoct with water out, 50-70 at a simmer minute (preferably 60 minutes), leach to obtain medicinal liquid, mix gained medicinal liquid twice;
3. Radix Glycyrrhizae is pushed to obtain to juice, mixed with the Rhizoma Pinelliae, Herba Asari, be put in marmite, soak 100-120 minute (preferably 110 minutes), then intense fire boils to boiling, turns 40-60 at a simmer minute (preferably 50 minutes), leaches to obtain medicinal liquid;
4. by Poria, Radix Angelicae Sinensis, Rhizoma Gastrodiae, Rhizoma Chuanxiong, the Radix Paeoniae Alba, Radix Bupleuri, Folium Nelumbinis, Pericarpium Citri Reticulatae, Rhizoma Alismatis, Flos Carthami, Rhizoma Ligustici, Radix Saposhnikoviae, Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, Pheretima, the rinse of Spica Prunellae clear water, be cut into bulk and put into marmite, the water that adds 2-4 times of weight portion (preferably 3 times), intense fire is fried open lard speech with literary allusions fiery 30-40 minute (preferably 35 minutes), filtered while hot obtains medicinal liquid, recrement is watered and continues to decoct 20-30 minute (preferably 25 minutes), filters to obtain medicinal liquid, mixes gained medicinal liquid twice;
5. Scorpio, Scolopendra are pulverized, cross 80-100 mesh sieve (preferably 90 orders) and obtain even medicated powder;
6. the whole medicinal liquids that mix above-mentioned gained, then mix with step medicated powder 5., sterile packaged obtains Chinese medicine decoction.
The preparation method of described powder is:
1. the Rhizoma Pinelliae, Herba Asari, Scorpio and Scolopendra are put in marmite, slow fire is fried removal toxicity;
2. take out the medical material of step in 1., together with remaining crude drug, be ground into the screening of sieving after powder, obtain uniform Chinese powder medicine.
Described Chinese powder medicine preparation method, step 1. middle slow fire is fried 15-30 minute (preferably 24 minutes).
Described Chinese powder medicine preparation method, the step 2. order number of middle sieve is 80-110 order (preferably 95 orders).
The preparation method of described capsule: Chinese powder medicine, according to the metering of 2-3 gram/(preferably 2.5 grams /), is made to capsule shape dosage form according to the processing method of capsule.
The application of Chinese medicine preparation described in the present invention also provides when the medicine of preparation migraine expelling wind and activating blood circulation.
The pharmacological effect of each crude drug is respectively:
Poria: nature and flavor with return through: sweet, light, flat.GUIXIN, lung, spleen, kidney channel.There is promoting diuresis to eliminate damp pathogen, spleen invigorating, the effect of mind calming.For edema oliguria, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in loose stool, irritability, palpitation with fear insomnia.
Concha Solen gouldii: base is former: be the shell of the huge first wedge freshwater mussel of Unionidae Cuneopsis animal or Lanceolaria animal short pleat lance freshwater mussel and sibling species thereof.Composition: this product is containing trace element manganese, ferrum, magnesium, copper, zinc etc.The property of medicine: salty, cool.Function cures mainly: eliminating stagnation expectorant, treating stranguria heat extraction, cooling blood for hemostasis, suppressing the hyperactive liver to relieve the wind syndrome.Cure mainly goiter, phlegm retention, gonorrhea, metrorrhagia, spits blood, and epistaxis is dizzy, tinnitus.
Radix Angelicae Sinensis: nature and flavor with return through sweet, acrid, warm.Return liver, the heart, spleen channel.Enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, the effect of loosening bowel to relieve constipation.For blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, rheumatic arthralgia, injury from falling down, ulcer sores, dryness of the intestine constipation.Radix Angelicae Sinensis (processed with wine) promoting blood circulation to restore menstrual flow.For amenorrhea dysmenorrhea, rheumatic arthralgia, injury from falling down.
Rhizoma Gastrodiae: base is former: the tuber of Wei Tian section Gastrodia plant Rhizoma Gastrodiae.Composition: Rhizoma Gastrodiae contains phenols: Gastrodine claims gastrodine, gastrodioside, 4-ethoxymethyl phenol, hydroxy benzaldehyde, 3,4-4-dihydroxy benzaldehyde; Aromatic compound: 4-acrinyl methyl ether etc.The property of medicine: sweet, pungent, flat.Return Liver Channel.Function cures mainly: relieving spasm by subduing liver-wind, suppressing the hyperactive liver sun, dispelling wind and removing obstruction in the collateral.Cure mainly anxious chronic infantile convulsion, tic contracture, tetanus, dizzy, headache, hemiplegia, limb fiber crops, rheumatic arthralgia.
Rhizoma Chuanxiong: nature and flavor with return through: pungent, temperature.Return liver, gallbladder, pericardium channel.There is blood-activating and qi-promoting, the effect of wind-expelling pain-stopping.For obstruction of qi in the chest and cardialgia, the twinge of the breast side of body, tumbling and swelling, menoxenia, amenorrhea dysmenorrhea, abdominal mass abdominal mass stomachache, headache, rheumatic arthralgia.
The Radix Paeoniae Alba: nature and flavor with return through, bitter, sour, be slightly cold.Return liver, spleen channel.There is nourishing blood for regulating menstruation, astringing YIN to stop sweating, easing the affected liver to relieve pain, stabilizes positive effect.For blood deficiency and yellow complexion, menoxenia, spontaneous perspiration, night sweat, hypochondriac pain, stomachache, limb pain twin, has a headache dizzy.
Radix Bupleuri: nature and flavor with return through, pungent, bitter, be slightly cold.Return liver, gallbladder, lung meridian.Have to evacuate and bring down a fever, dispersing the stagnated live-QI to relieve the stagnation of QI, the effect of elevate a turnable ladder yang-energy.For cold, fever, alternate attack of chill and fever, distending pain in the chest and hypochondrium, menoxenia, uterine prolapse, proctoptosis.
Haematitum: base is former: be oxide-based mineral corundum family bloodstone.Composition: main containing iron sesquioxide (Fe
2o
3), wherein ferrum 70%, oxygen 30%, and contain the impurity such as silicon, aluminum, titanium, magnesium, manganese, calcium, lead, arsenic.Nature and flavor with return through hardship, cold.Return liver, heart channel.There is suppressing the hyperactive liver and subsiding YANG, sending down the abnormal ascending QI, the effect of hemostasis.For vertigo and tinnitus, vomiting, eructation, singultus, pants, spits blood, epistaxis, metrostaxis.
Folium Nelumbinis: nature and flavor with return through hardship, flat.Return liver, spleen, stomach warp.There is clearing away summer-heat and eliminating dampness, sending up the lucid YANG, the effect of cooling blood for hemostasis.For summer-heat excessive thirst, diarrhea due to summer heat and dampness, diarrhea due to hypofunction of the spleen, heat in blood is told nosebleed, the metrorrhagia of having blood in stool.Burnt FOLIUM NELUMBINIS astringent therapy removing stasis to stop bleeding.For hemorrhage and puerperal blood faints.
The Rhizoma Pinelliae: nature and flavor with return through: pungent, warm; Poisonous.Return spleen, stomach, lung meridian.There is drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, the effect of dissolving lump and resolving mass.For damp-phlegm cold-phlegm, cough with asthma abundant expectoration, phlegm retention vertigo and palpitation, dizziness due to wind-phlegm, syncope due to accumulation of phlegm headache, vomiting regurgitation, breast gastral cavity painful abdominal mass is vexed, globus hystericus; External treatment carbuncle sucutaneous nodule.
Pericarpium Citri Reticulatae: nature and flavor with return through: bitter, pungent, temperature.Return lung, spleen channel.There is regulating qi-flowing for strengthening spleen, the effect of drying dampness to eliminate phlegm.For distension and fullness in the abdomen, lack of appetite and vomiting, cough with copious phlegm.
Rhizoma Alismatis: nature and flavor with return through: sweet, light, cold.Return kidney, urinary bladder channel.There is promoting diuresis to eliminate damp pathogen, expel the heat-evil, change the effect of turbid blood fat reducing.For dysuria, edema distension, the oliguria of having loose bowels, dizziness due to fluid-retention, the puckery pain of pyretic stranguria, hyperlipemia.
Os Draconis: base is former: for ancient times mammal as if the fossil of the skeleton of class, rhinoceros class, Hippocampal cortex etc.Nature and flavor with return through: sweet puckery, flat, nontoxic.Enter heart channel, Liver Channel, kidney channel, large intestine channel.There is tranquillizing the mind by relieving convulsion, arresting sweating controlling nocturnal emission with astringent drugs, hemostasis astringing intestine to stop diarrhea, the effect of promoting tissue regeneration and ulcer healing.Control infantile convulsion demented, palpitation with a distress feeling is forgetful, insomnia and dreamful sleep, and spontaneous sweating, seminal emission stranguria with turbid discharge, tells nosebleed and has blood in stool, bleeding not during menses, dysentery proctoptosis, ulcer does not close up for a long time.
Concha Ostreae: nature and flavor with return through: salty, be slightly cold.Return liver, gallbladder, kidney channel.There is tranquillization with heavy prescription, YANG hyperactivity suppressing nourishing YIN, the effect of hard masses softening and resolving.The insomnia that is used for palpitating with fear, dizzy ear toot, scrofula sucutaneous nodule, abdominal mass abdominal mass mass in the abdomen.Concha Ostreae (calcined) convergence is astringent or styptic treatment for spontaneous sweating, relieving gastric hyperacidity to alleviate stomachache.For spontaneous sweating, emission and spermatorrhea, bleeding not during menses, stomachache acid regurgitation.
Cornu Saigae Tataricae: base is former: for Bovidae Saigae Tataricae belongs to the angle of animal sahilite.Composition: sahilite angle is containing keratin, calcium phosphate, insoluble inorganic salt, lysine, serine, glutamic acid, phenylalanine, leucine, aspartic acid etc.The property of medicine: salty, cold.Return liver, heart channel.Function cures mainly: suppressing the hyperactive liver to relieve the wind syndrome, liver heat removing and eyesight improving, blood-cleaning detoxifying.Cure mainly liver-wind stirring up internally, infantile convulsion is twitched, the contracture of muscle arteries and veins; Headache due to hyperactivity of liver-YANG is dizzy, and liver-fire conjunctival congestion and swelling pain and heat in blood are hemorrhage, and epidemic febrile disease is sent out speckle, carbuncle sore tumefacting virus.
Radix Glycyrrhizae: sweet in the mouth, property is flat.There is QI invigorating invigorating middle warmer, relieving spasm to stop pain, the effect of eliminating fire and detoxication, for the disease of laryngopharynx swelling and pain.
Flos Carthami: base is former: Compositae, Flos Carthami platymiscium, dry tubular flower, orange red.Chemical composition: contain carthamone, neocarthamin, saffloside, Carthamus yellow and flavochrome.Another containing safflower oil, oil comprises Palmic acid, myristic acid, lauric acid, stearic acid, arachidic acid, oleic acid etc.Pharmacological action: have the effect of slight excited heart, reduction coronary resistance, increase coronary flow and Nutritional myocardium blood flow amount; Protect and improve myocardial ischemia, dwindling myocardial infarct size; Reddish yellow pigment separator can be to arrhythmia; Decoct, water extraction liquid, Carthamus yellow etc. can be expanded peripheral vessels, reduce blood pressure.Energy anticoagulant, fortifying fibre protein dissolution, reduces whole blood viscosity.Injection, ethanol extract, saffloside can significantly improve hypoxia-bearing capability, and the weary oxygen encephalopathy (HIE) of ischemia is had to protective effect.Nature and flavor with return through: pungent, temperature.GUIXIN, Liver Channel.The effect that has promoting blood circulation to restore menstrual flow, stasis-dispelling and pain-killing.Be used for controlling amenorrhea, lump in the abdomen, difficult labour, stillborn fetus, disease that postpartum lochia can't go, blood stasis are had a pain, carbuncle, injury from falling down.
Rhizoma Ligustici: nature and flavor with return through: pungent, temperature.Return urinary bladder channel.Dispel the wind, cold expelling, dehumidifying, the effect of pain relieving.For anemofrigid cold, top, mountain peak pain, rheumatic arthralgia.
Herba Asari: nature and flavor with return through: pungent, temperature.GUIXIN, lung, kidney channel.There is expelling wind and cold, wind-expelling pain-stopping, sensible, the effect of warming the lung to resolve fluid-retention.For anemofrigid cold, headache, toothache, nasal obstruction watery nasal discharge, allergic rhinitis, nasal sinusitis, rheumatic arthralgia, phlegm retention is breathed with cough.
Gypsum Fibrosum: Gypsum Fibrosum is monoclinic system mineral, main chemical compositions is calcium sulfate (CaSO
4) hydrate.Gypsum Fibrosum is natural dihydrate gypsum (CaSO both
42H
2o).Nature and flavor: pungent, sweet, be slightly cold.Attach to the lung and stomach meridians.Have clearing away heat-fire, relieving restlessness is quenched the thirst, the effect of convergence granulation promoting.Cure mainly: apoplexy cold and heat, heart subinverse gas is frightened to be breathed heavily, and xerostomia scorching tongue, can not cease, hardness and fullness in the abdomen pain, evil removing ghost, puerperium incised wound.Except seasonal epidemic pathogens headache fever of the body, the large heat of three warmers, skin heat, stagnation of QI in the intestines and stomach, expelling pathogenic factors from muscles by diaphoresis, the restlessness accompanied by ascending of QI of only quenching one's thirst, the sudden and violent gas of abdominal distention, the pharynx heat of panting, also can do bath soup.Cure the wound cold headache as split.Simmer tea with Herba Alii fistulosi, the pain of decaptitating.Control day row fanatic, wind syndrome of head revolves, and stimulating milk secretion is wiped tooth benefit tooth.Except gastric heat lung-heat, loose YIN pathogen, slow spleen QI invigorating.Stop Yangming Channel headache, fever with chills, day food in one's mouth hectic fever, drinking a large amount of water due to extreme thirst, heatstroke hectic fever, has a toothache.
Radix Saposhnikoviae: nature and flavor: pungent, sweet, tepor.Gui Jing: return bladder, lung, spleen, Liver Channel.Effect: expelling pathogenic wind from the body surface, removing dampness to relieve pain.Cure mainly: for affection of exogenous wind-cold, headache general pain, rheumatic arthralgia.
Scorpio: nature and flavor with return through: pungent, flat; Poisonous.Return Liver Channel.There is endogenous wind stopping spasmolytic, removing obstruction in the collateral to relieve pain, the effect of dispersing pathogen accumulation.For liver-wind stirring up internally, spasm is twitched, infantile convulsion, middle air port fish sticking its mouth out of the water, hemiplegia, tetanus, rheumatoid arthritis stubborn, migraine and general headache, skin infection, scrofula.
Scolopendra: nature and flavor with return through: pungent, temperature; Poisonous.Return Liver Channel.There is endogenous wind stopping spasmolytic, removing obstruction in the collateral to relieve pain, the effect of dispersing pathogen accumulation.For liver-wind stirring up internally, spasm is twitched, infantile convulsion, middle air port fish sticking its mouth out of the water, hemiplegia, tetanus, rheumatoid arthritis stubborn, migraine and general headache, skin infection, scrofula, snake bite and insect sting.
Radix Salviae Miltiorrhizae: nature and flavor are bitter, cold nature.Energy blood circulation promoting and blood stasis dispelling, removing heat from blood, calms the nerves.Enter the heart, spleen two warps.According to the < < book on Chinese herbal medicine > > that looks for the truth: Radix Salviae Miltiorrhizae has the effect into percardium removing blood stasis with potent drugs.Modern medicine study confirms, its energy coronary artery dilator, and increase coronary flow, improves myocardial ischemia, infraction and cardiac function, regulates the rhythm of the heart, and can expand peripheral blood vessel, improves microcirculation; Can improve body's hypoxia tolerance; There is anticoagulation, promote fibrinolytic, suppress platelet aggregation, suppress thrombotic effect; Can reduce blood fat, suppress coronary atherosclerosis and form; Can shorten the convalescent period of erythrocyte and hematochrome, Reticulocyte is increased, can promote the reparation of tissue, accelerate the healing of fracture; There is nervus centralis to have inhibitory action; There is antitumor action; Energy enhancing human body immunity function; Can reduce blood glucose; The various bacteria such as tubercule bacillus are had to inhibitory action.
Radix Paeoniae Rubra: sour in the mouth, hardship, cool in nature.Have eliminating stasis to stop pain, the effect of removing heat from blood detumescence, for stomachache, hypochondriac pain, discharging fresh blood stool, conjunctival congestion, carbuncle
Pheretima: nature and flavor with return through: salty, cold.Return liver, spleen, urinary bladder channel.Have heat clearing away arresting convulsion, dredging collateral, relievings asthma, the effect of diuresis.For unconsciousness due to high fever, infantile convulsion is twitched, arthralgia, numb limbs and tense tendons, hemiplegia, dyspnea and cough due to lung-heat, edema oliguria.
Concha Haliotidis: having another name called Carnis Haliotidis first, Herba Senecionis Scandentis, abalone shells, is the shell of Bao Kebao genus animal Haliotis diversicolor, haliotis discus hannai Ino, sheep Bao, haliotis ruber, ear Bao, white Bao etc.The property of medicine: salty in the mouth, cold in nature.Composition: main component is calcium carbonate, also has conchiolin and Choline.According to modern pharmacological research, find, this medical instrument has protecting the liver, expands trachea, in and the effect of gastric acid, improving eyesight removing nebula, dizzy for having a headache, blurring of vision, optic atrohic blindness nyctalopia.
Spica Prunellae: nature and flavor with return through: pungent, bitter, cold.Return liver, gallbladder meridian.There is purging liver-fire, improving eyesight, the effect of mass dissipating and swelling eliminating.For conjunctival congestion and swelling pain, order pearl nyctalgia, has a headache dizzy, scrofula, goiter, acute mastitis, nodules of the breast, distending pain of the breast.
Chinese medicine composition prescription science provided by the invention, the preparation method of various dosage forms is simple, products obtained therefrom taking convenience, in addition, technical characterstic of the present invention also shows:
1, in side, get Poria, Os Draconis, Concha Ostreae and Radix Salviae Miltiorrhizae for monarch, by improving immunity of organisms, reduce Vascular Permeability, improving microcirculation suppresses migrainous generation, adds tranquillization with heavy prescription, the YANG hyperactivity suppressing nourishing YIN effect of Concha Ostreae, more remarkable treatment effect.
2, take Radix Bupleuri, Gypsum Fibrosum is minister, and Radix Bupleuri is returned liver, gallbladder, lung meridian, have to evacuate to bring down a fever, and dispersing the stagnated live-QI to relieve the stagnation of QI, the effect of elevate a turnable ladder yang-energy, Gypsum Fibrosum can delay spleen QI invigorating, Yangming Channel headache only, can alleviate greatly the unfavorable symptom that migraine is brought.
3, supplementary drug thing is fewer but better, the dispelling wind and removing obstruction in the collateral of Rhizoma Gastrodiae, and the blood-activating and qi-promoting of Rhizoma Chuanxiong, the removing toxic substances pathogenic fire purging of Radix Glycyrrhizae, arranges in pairs or groups mutually with tonic.
Accompanying drawing explanation
Fig. 1 is for taking embodiment 5 product 20-40 year migraineur's therapeutic outcome quantity figure,
Fig. 2 is for taking embodiment 5 product 20-40 year migraineur's therapeutic outcome chart of percentage comparisons.
The specific embodiment
Below in conjunction with embodiment and experimental example, describe technical scheme of the present invention in detail, but protection domain is not by this restriction.
embodiment 1
The Chinese medicine preparation of migraine expelling wind and activating blood circulation, is prepared from by following bulk drugs: Poria 25g, Concha Solen gouldii 6g, Radix Angelicae Sinensis 10g, Rhizoma Gastrodiae 4g, Rhizoma Chuanxiong 8g, Radix Paeoniae Alba 9g, Radix Bupleuri 10g, Haematitum 8g, Folium Nelumbinis 12g, Rhizoma Pinelliae 10g, Pericarpium Citri Reticulatae 8g, Rhizoma Alismatis 10g, Os Draconis 25g, Concha Ostreae 22g, Cornu Saigae Tataricae 5g, Radix Glycyrrhizae 5g, Flos Carthami 6g, Rhizoma Ligustici 6g, Herba Asari 2g, Gypsum Fibrosum 18g, Radix Saposhnikoviae 8g, Scorpio 3g, Scolopendra 4g, Radix Salviae Miltiorrhizae 20g, Radix Paeoniae Rubra 12g, Pheretima 6g, Concha Haliotidis 3g, Spica Prunellae 5g.The preparation method of the Chinese medicine decoction of above-mentioned migraine expelling wind and activating blood circulation:
1. Concha Solen gouldii, Haematitum, Os Draconis, Concha Ostreae, Cornu Saigae Tataricae, Concha Haliotidis and Gypsum Fibrosum are smashed and are put into marmite, add vinegar to soak 10 minutes, after decoct with water, intense fire is fried open and turns slow fire boiling 80 minutes;
2. after filtering, obtain medicinal liquid, after medicinal residues continue to decoct with water out, 50 minutes at a simmer, leach to obtain medicinal liquid, mix gained medicinal liquid twice;
3. Radix Glycyrrhizae is pushed to obtain to juice, mixed with the Rhizoma Pinelliae, Herba Asari, be put in marmite, soak 100 minutes, then intense fire boils to boiling, turns 40 minutes at a simmer, leaches to obtain medicinal liquid;
4. by Poria, Radix Angelicae Sinensis, Rhizoma Gastrodiae, Rhizoma Chuanxiong, the Radix Paeoniae Alba, Radix Bupleuri, Folium Nelumbinis, Pericarpium Citri Reticulatae, Rhizoma Alismatis, Flos Carthami, Rhizoma Ligustici, Radix Saposhnikoviae, Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, Pheretima, the rinse of Spica Prunellae clear water, be cut into bulk and put into marmite, the water that adds 2 times of weight portions, intense fire is fried open lards speech with literary allusions fiery 30 minutes, filtered while hot obtains medicinal liquid, recrement is watered and continues to decoct 20 minutes, filters to obtain medicinal liquid, mixes gained medicinal liquid twice;
5. Scorpio, Scolopendra are pulverized, cross 80 mesh sieves and obtain even medicated powder;
6. the whole medicinal liquids that mix above-mentioned gained, then mix with step medicated powder 5., sterile packaged obtains Chinese medicine decoction.
The instructions of taking of decoction of the present invention: take twice (warm) each 350m1,7 days courses for the treatment of every day.
embodiment 2
The Chinese medicine preparation of migraine expelling wind and activating blood circulation, is prepared from by following bulk drugs: Poria 35g, Concha Solen gouldii 12g, Radix Angelicae Sinensis 20g, Rhizoma Gastrodiae 9g, Rhizoma Chuanxiong 16g, Radix Paeoniae Alba 18g, Radix Bupleuri 25g, Haematitum 18g, Folium Nelumbinis 20g, Rhizoma Pinelliae 14g, Pericarpium Citri Reticulatae 12g, Rhizoma Alismatis 18g, Os Draconis 35g, Concha Ostreae 36g, Cornu Saigae Tataricae 15g, Radix Glycyrrhizae 9g, Flos Carthami 12g, Rhizoma Ligustici 15g, Herba Asari 6g, Gypsum Fibrosum 28g, Radix Saposhnikoviae 12g, Scorpio 6g, Scolopendra 6g, Radix Salviae Miltiorrhizae 40g, Radix Paeoniae Rubra 22g, Pheretima 9g, Concha Haliotidis 9g, Spica Prunellae 12g.The preparation method of the Chinese powder medicine of above-mentioned migraine expelling wind and activating blood circulation:
1. the Rhizoma Pinelliae, Herba Asari, Scorpio and Scolopendra are put in marmite, slow fire is fried and within 15 minutes, is removed toxicity;
2. take out the medical material of step in 1., together with remaining crude drug, cross 80 mesh sieves screenings after being ground into powder, obtain uniform Chinese powder medicine.
Powder is made to 4g/ bag.Instructions of taking: every day 2-3 time, each one bag, with warm boiled water, 7 days courses for the treatment of.
Model case: Zhang, age: 26 years old; Sex: man, with ictal dim eyesight, limb fiber crops, headache, within 6 years, be chief complaint, patient has a headache at every turn, and outbreak is front first there is dim eyesight without obvious inducement, show as many bright line fluctuations, vibration up and down, continue 10 to 20 minutes, then occur a side numb limbs and tense tendons, do not accompany unable, time remaining approximately 20 minutes, sometimes can after several minutes, there is headache with lip and numbness of tongue tip, take both sides temples jumping pain as main, pain degree is heavier, activity can make headache increase the weight of, and with nausea and vomiting, each duration of seizure continues about 4 hours.After diagnosing for accompanying the migraine of typical tendency.
Take the Chinese powder medicine of the migraine expelling wind and activating blood circulation of this example gained, each one bag, every day twice, warm boiled water, 7 days is a course for the treatment of.Take after 14 days, pain degree obviously alleviates, and before outbreak, numb limbs and tense tendons disappears, and continues to take after three courses for the treatment of, and headache phenomenon disappears substantially, follows up a case by regular visits to three months again without recurrence.
embodiment 3
The Chinese medicine preparation of migraine expelling wind and activating blood circulation, is prepared from by following raw materials in part by weight medicine: Poria 29g, Concha Solen gouldii 8g, Radix Angelicae Sinensis 14g, Rhizoma Gastrodiae 5g, Rhizoma Chuanxiong 10g, Radix Paeoniae Alba 12g, Radix Bupleuri 15g, Haematitum 11g, Folium Nelumbinis 15g, Rhizoma Pinelliae 11g, Pericarpium Citri Reticulatae 9g, Rhizoma Alismatis 13g, Os Draconis 29g, Concha Ostreae 27g, Cornu Saigae Tataricae 9g, Radix Glycyrrhizae 6g, Flos Carthami 8g, Rhizoma Ligustici 9g, Herba Asari 3g, Gypsum Fibrosum 22g, Radix Saposhnikoviae 9g, Scorpio 4g, Scolopendra 4g, Radix Salviae Miltiorrhizae 28g, Radix Paeoniae Rubra 16g, Pheretima 7g, Concha Haliotidis 5g, Spica Prunellae 8g.
The Chinese medicinal capsule preparation method of migraine expelling wind and activating blood circulation is: the metering by Chinese powder medicine according to 2 grams/, according to the processing method of capsule, make capsule shape dosage form.Capsule adopts every day twice, and each 2, with warm boiled water, 7 days courses for the treatment of.
Model case: xxx, the age: 20 years old; Sex: female; Main suit: more than the bimester of the migraine of left side, numb three days of companion's left hand.History of present illness: bimester before without inducement, there is left side migraine, rise morning obviously, be throbbing pain, continue approximately ten minutes at every turn, can spontaneous remission, during pain, be radiated to left eye, left side is facial.Companion's rotatory vertigo, feels sick, tinnitus.Dizzyly stand suddenly obviously when squatting position, when serious, do not hold up object astasia.Onset is come without fainting, vomiting etc., normal visual acuity.Sleep poor, diet is owed.Diagnosis: migraine.
Take this example gained Chinese medicinal capsule, every day twice, each two, warm boiled water, seven days is a course for the treatment of.Take 21 days, pain relief, disease time significantly shortens, and continues to take two courses for the treatment of, and headache disappears substantially, and without other malaise symptoms, patient's recovery from illness, with visiting three months without recurrence.
embodiment 4
The Chinese medicine preparation of migraine expelling wind and activating blood circulation, is prepared from by following raw materials in part by weight medicine: Poria 31g, Concha Solen gouldii 10g, Radix Angelicae Sinensis 17g, Rhizoma Gastrodiae 7g, Rhizoma Chuanxiong 15g, Radix Paeoniae Alba 15g, Radix Bupleuri 20g, Haematitum 15g, Folium Nelumbinis 17g, Rhizoma Pinelliae 13g, Pericarpium Citri Reticulatae 11g, Rhizoma Alismatis 15g, Os Draconis 31g, Concha Ostreae 31g, Cornu Saigae Tataricae 11g, Radix Glycyrrhizae 8g, Flos Carthami 10g, Rhizoma Ligustici 12g, Herba Asari 5g, Gypsum Fibrosum 24g, Radix Saposhnikoviae 11g, Scorpio 5g, Scolopendra 5g, Radix Salviae Miltiorrhizae 32g, Radix Paeoniae Rubra 18g, Pheretima 8g, Concha Haliotidis 7g, Spica Prunellae 9g.The preparation method of the Chinese medicine preparation powder of migraine expelling wind and activating blood circulation:
The preparation method of the Chinese powder medicine of above-mentioned migraine expelling wind and activating blood circulation:
1. the Rhizoma Pinelliae, Herba Asari, Scorpio and Scolopendra are put in marmite, slow fire is fried and within 24 minutes, is removed toxicity;
2. take out the medical material of step in 1., together with remaining crude drug, cross 95 mesh sieves screenings after being ground into powder, obtain uniform Chinese powder medicine.
Powder is made to 4g/ bag.Instructions of taking: every day 2-3 time, each one bag, with warm boiled water, 7 days courses for the treatment of.
embodiment 5
The Chinese medicine preparation of migraine expelling wind and activating blood circulation, is prepared from by following raw materials in part by weight medicine: Poria 30g, Concha Solen gouldii 9g, Radix Angelicae Sinensis 15g, Rhizoma Gastrodiae 6.5g, Rhizoma Chuanxiong 12g, Radix Paeoniae Alba 13.5g, Radix Bupleuri 17.5g, Haematitum 13g, Folium Nelumbinis 16g, Rhizoma Pinelliae 12g, Pericarpium Citri Reticulatae 10g, Rhizoma Alismatis 14g, Os Draconis 30g, Concha Ostreae 29g, Cornu Saigae Tataricae 10g, Radix Glycyrrhizae 7g, Flos Carthami 9g, Rhizoma Ligustici 10.5g, Herba Asari 4g, Gypsum Fibrosum 23g, Radix Saposhnikoviae 10g, Scorpio 4.5g, Scolopendra 5g, Radix Salviae Miltiorrhizae 30g, Radix Paeoniae Rubra 17g, Pheretima 7.5g, Concha Haliotidis 6g, Spica Prunellae 8.5g.
The preparation method of the Chinese medicine preparation decoction of above-mentioned migraine expelling wind and activating blood circulation:
1. Concha Solen gouldii, Haematitum, Os Draconis, Concha Ostreae, Cornu Saigae Tataricae, Concha Haliotidis and Gypsum Fibrosum are smashed and are put into marmite, add vinegar to soak 15 minutes, after decoct with water, intense fire is fried open and turns slow fire boiling 90 minutes;
2. after filtering, obtain medicinal liquid, after medicinal residues continue to decoct with water out, 60 minutes at a simmer, leach to obtain medicinal liquid, mix gained medicinal liquid twice;
3. Radix Glycyrrhizae is pushed to obtain to juice, mixed with the Rhizoma Pinelliae, Herba Asari, be put in marmite, soak 110 minutes, then intense fire boils to boiling, turns 50 minutes at a simmer, leaches to obtain medicinal liquid;
4. by Poria, Radix Angelicae Sinensis, Rhizoma Gastrodiae, Rhizoma Chuanxiong, the Radix Paeoniae Alba, Radix Bupleuri, Folium Nelumbinis, Pericarpium Citri Reticulatae, Rhizoma Alismatis, Flos Carthami, Rhizoma Ligustici, Radix Saposhnikoviae, Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, Pheretima, the rinse of Spica Prunellae clear water, be cut into bulk and put into marmite, the water that adds 3 times of weight portions, intense fire is fried open lards speech with literary allusions fiery 35 minutes, filtered while hot obtains medicinal liquid, recrement is watered and continues to decoct 25 minutes, filters to obtain medicinal liquid, mixes gained medicinal liquid twice;
5. Scorpio, Scolopendra are pulverized, cross 90 mesh sieves and obtain even medicated powder;
6. the whole medicinal liquids that mix above-mentioned gained, then mix with step medicated powder 5., sterile packaged obtains Chinese medicine decoction.
The instructions of taking of decoction of the present invention: take twice (warm) each 350m1,7 days courses for the treatment of every day.
test example 1the clinical practice of the Chinese medicine decoction of embodiment 5 gained migraine expelling wind and activating blood circulation: during 2013, in hospital, screen 320 routine migraineurs, oldest 40 years old, minimal ages 20 years old, 25.5 years old mean age, wherein women is 200 people, male is 120 people.Be divided at random two groups, experimental group and matched group, experimental group is taken embodiment 5 products obtained therefroms, and matched group is taken other medicine (such as ibuprofen, ZHENGTIAN WAN, nimodipine or Radix Salviae Miltiorrhizae Tabellae).
Inclusion criteria: (1) medical history and general health check-up and neurologic check are not pointed out organic disease.(2) headache outbreak shows effect more than 3 times more than 5 times or in nearly 2 months, and outbreak continues 4～72h.(3) headache be take one-sidedly as main, and degree be take moderate, severe as main, is pulsation jumping pain or twinge, distending pain.(4) or with nausea and vomiting, photophobia, phonophobia or there is premonitory symptom.(5) get rid of: headache epilepsy, intracranial mass lesion, cerebral trauma, cerebrovascular accident, diseases of the five sense organs headache, the headache that whole body is poisoning and metabolism causes.
Headache grading: I level: not bitterly; II level: mild pain has a headache gently, does not affect work, study; III level: moderate pain has a headache moderate, still can tolerate, and work and study is had to impact, but do not stop action; IV level: severe pain has a headache heavily, affects work and study, can not activity.
Criterion of therapeutical effect: effective: times of headache reduces more than 70%, degree improvement reaches 2 grades, can normal work and study.Effective: times of headache reduces more than 30%, degree improvement reaches 1 grade, and the persistent period shortens, though headache outbreak can tolerate, can adhere to work and study.Invalid: after treatment, headache is without taking a turn for the better.
From accompanying drawing 1,2: therapeutic effect: experimental group obvious effective rate is 81.8%, effective percentage is 13.2%, and inefficiency is 5%, and total effective rate reaches 95%, and matched group total effective rate is 90%.
Prescription science of the present invention, side's justice are correctly, monarch compatibility is reasonable, the medicines such as Poria, Os Draconis, Radix Salviae Miltiorrhizae, Radix Bupleuri, Gypsum Fibrosum complement each other, can heighten the effect of a treatment and can improve immunity of organisms, total effective rate can reach 95%, alleviate greatly patient's cephalagra, reduced the impact of uncomfortable disease on learning life.
It should be pointed out that the specific embodiment is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, within the spirit and principles in the present invention all, any modification of doing, replacement, improvement etc., within all should being included in protection scope of the present invention.
Claims (10)
1. migraine expelling wind and activating blood circulation Chinese medicine preparation, is characterized in that, the main raw material(s) that takes off row weight proportion is prepared from: Poria 25-35; Concha Solen gouldii 6-12; Radix Angelicae Sinensis 10-20; Rhizoma Gastrodiae 4-9; Rhizoma Chuanxiong 8-16; Radix Paeoniae Alba 9-18; Radix Bupleuri 10-25; Haematitum 8-18; Folium Nelumbinis 12-20; Rhizoma Pinelliae 10-14; Pericarpium Citri Reticulatae 8-12; Rhizoma Alismatis 10-18; Os Draconis 25-35; Concha Ostreae 22-36; Cornu Saigae Tataricae 5-15; Radix Glycyrrhizae 5-9; Flos Carthami 6-12; Rhizoma Ligustici 6-15; Herba Asari 2-6; Gypsum Fibrosum 18-28; Radix Saposhnikoviae 8-12; Scorpio 3-6; Scolopendra 4-6; Radix Salviae Miltiorrhizae 20-40; Radix Paeoniae Rubra 12-22; Pheretima 6-9; Concha Haliotidis 3-9; Spica Prunellae 5-12.
2. Chinese medicine preparation as claimed in claim 1, is characterized in that, the main raw material(s) that takes off row weight proportion is prepared from: Poria 29-31; Concha Solen gouldii 8-10; Radix Angelicae Sinensis 14-17; Rhizoma Gastrodiae 5-7; Rhizoma Chuanxiong 10-15; Radix Paeoniae Alba 12-15; Radix Bupleuri 15-20; Haematitum 11-15; Folium Nelumbinis 15-17; Rhizoma Pinelliae 11-13; Pericarpium Citri Reticulatae 9-11; Rhizoma Alismatis 13-15; Os Draconis 29-31; Concha Ostreae 27-31; Cornu Saigae Tataricae 9-11; Radix Glycyrrhizae 6-8; Flos Carthami 8-10; Rhizoma Ligustici 9-12; Herba Asari 3-5; Gypsum Fibrosum 22-24; Radix Saposhnikoviae 9-11; Scorpio 4-5; Scolopendra 4-5; Radix Salviae Miltiorrhizae 28-32; Radix Paeoniae Rubra 16-18; Pheretima 7-8; Concha Haliotidis 5-7; Spica Prunellae 8-9.
3. Chinese medicine preparation as claimed in claim 1, is characterized in that, the main raw material(s) that takes off row weight proportion is prepared from: Poria 30, Concha Solen gouldii 9, Radix Angelicae Sinensis 15, Rhizoma Gastrodiae 6.5, Rhizoma Chuanxiong 12, the Radix Paeoniae Alba 13.5, Radix Bupleuri 17.5, Haematitum 13, Folium Nelumbinis 16, the Rhizoma Pinelliae 12, Pericarpium Citri Reticulatae 10, Rhizoma Alismatis 14, Os Draconis 30, Concha Ostreae 29, Cornu Saigae Tataricae 10, Radix Glycyrrhizae 7, Flos Carthami 9, Rhizoma Ligustici 10.5, Herba Asari 4, Gypsum Fibrosum 23, Radix Saposhnikoviae 10, Scorpio 4.5, Scolopendra 5, Radix Salviae Miltiorrhizae 30, Radix Paeoniae Rubra 17, Pheretima 7.5, Concha Haliotidis 6, Spica Prunellae 8.5.
4. the Chinese medicine preparation as described in as arbitrary in claim 1-3, is characterized in that, this Chinese medicine preparation is made to pharmaceutically acceptable decoction, powder and capsule.
5. as the Chinese medicine preparation as described in arbitrary in claim 4, it is characterized in that, the preparation process of described decoction is as follows:
1. Concha Solen gouldii, Haematitum, Os Draconis, Concha Ostreae, Cornu Saigae Tataricae, Concha Haliotidis and Gypsum Fibrosum are smashed and are put into marmite, add vinegar to soak 10-20 minute (preferably 15 minutes), after decoct with water, intense fire is fried open and turns slow fire boiling 80-100 minute (preferably 90 minutes);
2. after filtering, obtain medicinal liquid, after medicinal residues continue to decoct with water out, 50-70 at a simmer minute (preferably 60 minutes), leach to obtain medicinal liquid, mix gained medicinal liquid twice;
3. Radix Glycyrrhizae is pushed to obtain to juice, mixed with the Rhizoma Pinelliae, Herba Asari, be put in marmite, soak 100-120 minute (preferably 110 minutes), then intense fire boils to boiling, turns 40-60 at a simmer minute (preferably 50 minutes), leaches to obtain medicinal liquid;
4. by Poria, Radix Angelicae Sinensis, Rhizoma Gastrodiae, Rhizoma Chuanxiong, the Radix Paeoniae Alba, Radix Bupleuri, Folium Nelumbinis, Pericarpium Citri Reticulatae, Rhizoma Alismatis, Flos Carthami, Rhizoma Ligustici, Radix Saposhnikoviae, Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, Pheretima, the rinse of Spica Prunellae clear water, be cut into bulk and put into marmite, the water that adds 2-4 times of weight portion (preferably 3 times), intense fire is fried open lard speech with literary allusions fiery 30-40 minute (preferably 35 minutes), filtered while hot obtains medicinal liquid, recrement is watered and continues to decoct 20-30 minute (preferably 25 minutes), filters to obtain medicinal liquid, mixes gained medicinal liquid twice;
5. Scorpio, Scolopendra are pulverized, cross 80-100 mesh sieve (preferably 90 orders) and obtain even medicated powder;
6. the whole medicinal liquids that mix above-mentioned gained, then mix with step medicated powder 5., sterile packaged obtains Chinese medicine decoction.
6. Chinese medicine preparation as claimed in claim 4, is characterized in that, the preparation method of described powder is:
1. the Rhizoma Pinelliae, Herba Asari, Scorpio and Scolopendra are put in marmite, slow fire is fried removal toxicity;
2. take out the medical material of step in 1., together with remaining crude drug, be ground into the screening of sieving after powder, obtain uniform Chinese powder medicine.
7. Chinese powder medicine as claimed in claim 6, is characterized in that, described step 1. middle slow fire is fried 15-30 minute (preferably 24 minutes).
8. Chinese medicine preparation as claimed in claim 6, is characterized in that, the described step 2. order number of middle sieve is 80-110 order (preferably 95 orders).
9. Chinese medicine preparation as claimed in claim 4, is characterized in that, the preparation method of described capsule is: Chinese powder medicine, according to the metering of 2-3 gram/(preferably 2.5 grams /), is made to capsule shape dosage form according to the processing method of capsule.
10. the application of the Chinese medicine preparation as described in as arbitrary in claim 1-3 when preparation migraine expelling wind and activating blood circulation medicine.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104586978A (en) * | 2015-01-04 | 2015-05-06 | 霍山县中医院 | Traditional Chinese medicine for treating migraine |
| CN105106332A (en) * | 2015-09-22 | 2015-12-02 | 延边利孚生物科技有限公司 | Traditional Chinese medicine composition for treating neuropathic headache disease and preparation method |
| CN105213690A (en) * | 2015-11-10 | 2016-01-06 | 张在芬 | One treats migrainous Chinese medicine composition |
| CN106074999A (en) * | 2016-08-01 | 2016-11-09 | 黄平县兴且民族民间中草医药科学发展有限责任公司 | One treats migrainous Chinese medicine formula |
| CN116098933A (en) * | 2023-03-20 | 2023-05-12 | 河南中医药大学 | Traditional Chinese medicine for treating intractable headache |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20110078606A (en) * | 2009-12-31 | 2011-07-07 | (주)아모레퍼시픽 | Composition for inhibiting platelet aggregation containing ginseng fruit extract |
| CN103505699A (en) * | 2013-08-18 | 2014-01-15 | 许建成 | Traditional Chinese medicine preparation for treating nervous headache |
-
2014
- 2014-09-03 CN CN201410444084.8A patent/CN104173773A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20110078606A (en) * | 2009-12-31 | 2011-07-07 | (주)아모레퍼시픽 | Composition for inhibiting platelet aggregation containing ginseng fruit extract |
| CN103505699A (en) * | 2013-08-18 | 2014-01-15 | 许建成 | Traditional Chinese medicine preparation for treating nervous headache |
Non-Patent Citations (1)
| Title |
|---|
| 梁晋芳: "芎芷石膏汤合桃红四物汤加减治疗偏头痛42例", 《山西中医》 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104586978A (en) * | 2015-01-04 | 2015-05-06 | 霍山县中医院 | Traditional Chinese medicine for treating migraine |
| CN105106332A (en) * | 2015-09-22 | 2015-12-02 | 延边利孚生物科技有限公司 | Traditional Chinese medicine composition for treating neuropathic headache disease and preparation method |
| CN105213690A (en) * | 2015-11-10 | 2016-01-06 | 张在芬 | One treats migrainous Chinese medicine composition |
| CN106074999A (en) * | 2016-08-01 | 2016-11-09 | 黄平县兴且民族民间中草医药科学发展有限责任公司 | One treats migrainous Chinese medicine formula |
| CN116098933A (en) * | 2023-03-20 | 2023-05-12 | 河南中医药大学 | Traditional Chinese medicine for treating intractable headache |
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Application publication date: 20141203 |