CN104689240A - Medicine for treating Qi-stagnation and blood stasis type chloasma and preparation method thereof - Google Patents

Medicine for treating Qi-stagnation and blood stasis type chloasma and preparation method thereof Download PDF

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CN104689240A
CN104689240A CN201510118295.7A CN201510118295A CN104689240A CN 104689240 A CN104689240 A CN 104689240A CN 201510118295 A CN201510118295 A CN 201510118295A CN 104689240 A CN104689240 A CN 104689240A
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rhizoma
medicine
radix
cortex
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许艳静
王竞鹏
杨孝良
王丽萍
王学良
兰克涛
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王竞鹏
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Abstract

The invention discloses a medicine for treating Qi-stagnation and blood stasis type chloasma and a preparation method thereof. The medicine is prepared by eclipta, caulis sargentodoxae, large-leaved gentian, gynostemma pentaphylla, fructus aurantii, nux prinsepiae, testiset penis phocae, iris ensata thumb, hippocampus, angelica, rhizoma sparganii, curcuma zedoary, rhizome of glabrous greenbrier, moutan bark, rhizoma alismatis, rhizoma anemarrhenae, corydalis bowerihemsl., cortex phellodendri, cortex lycii radicis, herba melastomatis dodecandri, bamboo fern, pericarpium citri reticulatae, kohlrabi, rhizoma cyperi, melastoma sanguineum, radix paeoniae rubra, impure mirabilite, polygonum sagittatum, euphorbia maculata, tuber fleeceflower stem, rubus hirsutus and viola variegate. The medicine provided by the invention has the effects of regulating vital energy and promoting blood flow and removing stasis and ecchymoses, is mainly used for treating the Qi-stagnation and blood stasis type chloasma, and has the advantages of being fast to take effect, high in effective rate, definite in curative effect, short in treatment course, low in price, and is free from toxic and side effects.

Description

A kind ofly treat medicine of qi stagnation and blood stasis type chloasma and preparation method thereof
Technical field
The present invention relates to technical field of pharmaceuticals, particularly a kind ofly treat medicine of qi stagnation and blood stasis type chloasma and preparation method thereof.
Background technology
Chloasma has another name called chloasma hepaticum, betides the posteriority hyperpigmentation dermatoses of face, is apt to occur in women, particularly the women of trimester of pregnancy, puerperal and oral contraceptive.Erythra symmetry distribution around face, volume, two cheeks, bridge of the nose both sides, lip, skin of chin, in refer to lid to coin size or in hand size, filbert or crineous in irregular shape sinks speckle, boundary is obvious or smudgy, can be fused into sheet.No conscious sympton, chronic process, Exposure to Sunlight postemphasis, is more common in young and middle-aged women, and the course of disease is chronic, and the state of an illness has certain seasonality, and Xia Chongdong is light.
The cardinal symptom of chloasma comprises the following aspects: 1, send out around the cheekbone of face, volume and mouth, multipair title is butterfly-like, therefore has another name called & ldquo.2, initial colour is as dust and dirt, with the passing of time deepens, and becomes terra brown or dark brown, withered dark not damp.3, size is indefinite, and spot edge is clear, smooth surface, and NIP reacts, without sufferings.4, often use oral contraceptive and pregnant female, face there will be the one that & ldquo and cyasma & rdquo also belongs to chloasma.5, women has chloasma person many with menoxenia, distention and pain of breast before menstruation, or chronic disease.6, male's patient with chloasma is many with sexual impotence, premature ejaculation, gastrointestinal dysfunction etc.7, the day sunburn that often Exposure to Sunlight is formed also is the one of chloasma.
Clinically chloasma is divided into three types: 1. mid-face type: the most common, skin lesion is distributed in forehead, cheek, upper lip, nose and lower jaw part; 2. buccal type: skin lesion is mainly positioned at bilateral buccal and nose; 3. lower jaw type: skin lesion is mainly positioned at lower jaw, occasionally involves cervical region V-arrangement district.
The traditional Chinese medical science is thought, liver is lost bar and reaches, mechanism of qi pent-up, strongly fragrant fire-transformation of a specified duration, cloudy blood of burning, and hematogenous blockage, can cause face qi-blood disharmony; Deficiency-weakness of spleen-QI, transporting is lost strong, and can not change spermatogenesis micro-, then QI and blood can not be moistened in face; Insufficiency of kidney-YANG, the pathological changes such as deficiency of kidney-essence all can cause face generation chloasma.
Theory of Chinese medical science thinks that the etiology and pathogenesis of chloasma is by the following aspects: pathogenesis and dialectical: the traditional Chinese medical science is thought, primary disease is how in close relations with liver,spleen,kidney, and QI-blood failing to nourish upward is main pathogenesis in face.Differentiation of symptoms and signs for classification of syndrome is as follows: 1. liver-kidney yin deficiency: face symmetry brown patch, soreness of the waist and knees, and sternal rib pain, dysphoria with feverish sensation in the chest palms and soles, sleeps not good enough.Women often has menoxenia or other chronic diseases.Thin white fur of tongue, stringy and thready pulse or heavy thin.The hepatic and renal YIN deficiency, qi-blood disharmony.2. caused by hepatic stagnation qi stagnation: Facial symmetry yellowish-brown patch, fullness and distention in the chest and hypochondrium, emotion is irritable, and dreaminess is had a sleepless night.Stringy and rolling pulse or thin string.Stagnation of QI due to depression of the liver, qi-blood disharmony.3. insufficiency of the spleen type of latent damp: speckle color ash is brown, shape such as dust adheres to, and with fatigue and weak, indigestion and loss of appetite sleepy, menstruation color is light, and leucorrhea amount is many, and pale tongue is fat, while there is indentation, tongue is greasy in vain, soft pulse or thin.Deficiency of spleen-QI is stagnant, wet stasis of blood spotting.4, qi stagnation and blood stasis type: speckle color ash is brown or dark brown, mostly have chronic hepatitis medical history, or menstruation color secretly has clot, or a dysmenorrhea, dimly red tongue or: have ecchymosis, tire is thin, hesitant pulse.Qi depression to blood stasis, blood does not go up honor.
Current western medical treatment chloasma mainly adopts the combination of inner and outside, first will dispel the cause of disease, and strictly sun-proof.Medicine for external use is the most effectively Kligman formula: 5% hydroquinone, 0.1% tretinoin and 0.1% dexamethasone.Conventional medicine is the white QUBAN SHUANG of silk, Hydrochinone Cream.Have some whitening cosmetics to contain the whitening compositions such as arbutin, vitamin C/E and derivant thereof, some Flavonoids and Polyphenols extract, nicotiamide on the market, external also has certain effect, can be with the use of.No matter be skin-lightening cosmetic or medicine, service time at least just will can see effect more than two months, needed to adhere to.Fruit acid changes the treatment such as skin and vitamin C iontophoresis in addition also reasonable therapeutic effect.Also have some medicines such as JIAWEI XIAOYAO SAN, TAOHONG SIWU TANG etc. may be helpful, but these medicines need long-term taking, can not take effect in a short time.The treatment of chloasma is more difficult in a word, requires patience, and slowly nurses one's health.
Summary of the invention
Technical problem to be solved by this invention is, there is provided a kind of and treat medicine of qi stagnation and blood stasis type chloasma and preparation method thereof, the present invention has vital energy regualting and blood circulation-promoting, effect of eliminating blood stasis and removing ecchymoses, cure mainly qi stagnation and blood stasis type chloasma, have rapid-action, effective percentage is high, determined curative effect, treatment short treating period, have no side effect, the advantages such as price is low.
In order to solve the problems of the technologies described above, the invention provides a kind of medicine for the treatment of qi stagnation and blood stasis type chloasma, wherein, following raw medicinal material is comprised: Herba Ecliptae, Caulis Sargentodoxae, Radix Gentianae Macrophyllae, Herb Gynostemmae Pentaphylli, Fructus Aurantii, Nux Prinsepiae, Testis et penis callorhini, Chinese small iris, Hippocampus, Radix Angelicae Sinensis, Rhizoma Sparganii, Rhizoma Curcumae, Rhizoma Smilacis, Cortex Moutan, Rhizoma Alismatis, the Rhizoma Anemarrhenae, flatstiped corydalis herb, Cortex Phellodendri, Cortex Lycii, Herba Melastomatis Dodecandri, Coniogramme japonica (Thunb.) Diels, Pericarpium Citri Reticulatae, Corm Brassicae caulorapae, Rhizoma Cyperi, Radix Melastomatis Sanguinei, Radix Paeoniae Rubra, Mirabilitum, arrow leaf knotweed, Herba Euphorbiae supinae, Caulis Polygoni Multiflori, Fructus rubi tephrodis, Cortex Cinnamomi and Viola variegata.
Wherein, in described medicine, the ratio of weight and number of each raw medicinal material can be preferably: Herba Ecliptae 10 ~ 25 parts, Caulis Sargentodoxae 10 ~ 35 parts, Radix Gentianae Macrophyllae 10 ~ 30 parts, Herb Gynostemmae Pentaphylli 15 ~ 35 parts, Fructus Aurantii 9 ~ 20 parts, Nux Prinsepiae 12 ~ 24 parts, Testis et penis callorhini 11 ~ 21 parts, Chinese small iris 10 ~ 30 parts, Hippocampus 14 ~ 28 parts, Radix Angelicae Sinensis 15 ~ 35 parts, Rhizoma Sparganii 12 ~ 30 parts, Rhizoma Curcumae 10 ~ 28 parts, Rhizoma Smilacis 12 ~ 26 parts, Cortex Moutan 14 ~ 30 parts, Rhizoma Alismatis 15 ~ 28 parts, the Rhizoma Anemarrhenae 10 ~ 25 parts, flatstiped corydalis herb 15 ~ 30 parts, Cortex Phellodendri 15 ~ 25 parts, Cortex Lycii 14 ~ 28 parts, Herba Melastomatis Dodecandri 10 ~ 25 parts, Coniogramme japonica (Thunb.) Diels 10 ~ 35 parts, Pericarpium Citri Reticulatae 11 ~ 27 parts, Corm Brassicae caulorapae 10 ~ 28 parts, Rhizoma Cyperi 15 ~ 35 parts, Radix Melastomatis Sanguinei 13 ~ 25 parts, Radix Paeoniae Rubra 10 ~ 25 parts, Mirabilitum 14 ~ 26 parts, arrow leaf knotweed 10 ~ 30 parts, Herba Euphorbiae supinae 17 ~ 35 parts, Caulis Polygoni Multiflori 15 ~ 36 parts, Fructus rubi tephrodis 13 ~ 28 parts, Cortex Cinnamomi 14 ~ 30 parts and Viola variegata 13 ~ 33 parts.
Wherein, in described medicine, the ratio of weight and number of each raw medicinal material can also be preferably: Herba Ecliptae 15 ~ 24 parts, Caulis Sargentodoxae 13 ~ 32 parts, Radix Gentianae Macrophyllae 14 ~ 30 parts, Herb Gynostemmae Pentaphylli 15 ~ 28 parts, Fructus Aurantii 11 ~ 20 parts, Nux Prinsepiae 14 ~ 22 parts, Testis et penis callorhini 13 ~ 19 parts, Chinese small iris 13 ~ 28 parts, Hippocampus 15 ~ 22 parts, Radix Angelicae Sinensis 16 ~ 32 parts, Rhizoma Sparganii 16 ~ 29 parts, Rhizoma Curcumae 15 ~ 26 parts, Rhizoma Smilacis 14 ~ 25 parts, Cortex Moutan 17 ~ 23 parts, Rhizoma Alismatis 16 ~ 25 parts, the Rhizoma Anemarrhenae 13 ~ 21 parts, flatstiped corydalis herb 17 ~ 20 parts, Cortex Phellodendri 16 ~ 22 parts, Cortex Lycii 16 ~ 24 parts, Herba Melastomatis Dodecandri 13 ~ 21 parts, Coniogramme japonica (Thunb.) Diels 12 ~ 32 parts, Pericarpium Citri Reticulatae 13 ~ 25 parts, Corm Brassicae caulorapae 15 ~ 26 parts, Rhizoma Cyperi 17 ~ 34 parts, Radix Melastomatis Sanguinei 16 ~ 23 parts, Radix Paeoniae Rubra 11 ~ 20 parts, Mirabilitum 18 ~ 24 parts, arrow leaf knotweed 14 ~ 30 parts, Herba Euphorbiae supinae 18 ~ 35 parts, Caulis Polygoni Multiflori 15 ~ 34 parts, Fructus rubi tephrodis 13 ~ 26 parts, Cortex Cinnamomi 15 ~ 30 parts and Viola variegata 13 ~ 31 parts.
Wherein, in described medicine, the ratio of weight and number of each raw medicinal material can be preferably again: Herba Ecliptae 22 parts, Caulis Sargentodoxae 30 parts, Radix Gentianae Macrophyllae 28 parts, Herb Gynostemmae Pentaphylli 15 parts, Fructus Aurantii 17 parts, Nux Prinsepiae 14 parts, Testis et penis callorhini 15 parts, Chinese small iris 20 parts, Hippocampus 22 parts, Radix Angelicae Sinensis 32 parts, Rhizoma Sparganii 29 parts, Rhizoma Curcumae 24 parts, Rhizoma Smilacis 23 parts, Cortex Moutan 21 parts, Rhizoma Alismatis 16 parts, the Rhizoma Anemarrhenae 13 parts, flatstiped corydalis herb 20 parts, Cortex Phellodendri 19 parts, Cortex Lycii 16 parts, Herba Melastomatis Dodecandri 15 parts, Coniogramme japonica (Thunb.) Diels 32 parts, Pericarpium Citri Reticulatae 25 parts, Corm Brassicae caulorapae 24 parts, Rhizoma Cyperi 32 parts, Radix Melastomatis Sanguinei 21 parts, Radix Paeoniae Rubra 20 parts, Mirabilitum 24 parts, arrow leaf knotweed 30 parts, Herba Euphorbiae supinae 35 parts, Caulis Polygoni Multiflori 32 parts, Fructus rubi tephrodis 24 parts, Cortex Cinnamomi 30 parts and Viola variegata 31 parts.
Wherein, in described medicine, the ratio of weight and number of each raw medicinal material can be preferably again: Herba Ecliptae 17 parts, Caulis Sargentodoxae 32 parts, Radix Gentianae Macrophyllae 18 parts, Herb Gynostemmae Pentaphylli 25 parts, Fructus Aurantii 14 parts, Nux Prinsepiae 22 parts, Testis et penis callorhini 19 parts, Chinese small iris 24 parts, Hippocampus 22 parts, Radix Angelicae Sinensis 32 parts, Rhizoma Sparganii 26 parts, Rhizoma Curcumae 24 parts, Rhizoma Smilacis 20 parts, Cortex Moutan 21 parts, Rhizoma Alismatis 17 parts, the Rhizoma Anemarrhenae 13 parts, flatstiped corydalis herb 17 parts, Cortex Phellodendri 22 parts, Cortex Lycii 24 parts, Herba Melastomatis Dodecandri 21 parts, Coniogramme japonica (Thunb.) Diels 30 parts, Pericarpium Citri Reticulatae 23 parts, Corm Brassicae caulorapae 24 parts, Rhizoma Cyperi 32 parts, Radix Melastomatis Sanguinei 22 parts, Radix Paeoniae Rubra 20 parts, Mirabilitum 24 parts, arrow leaf knotweed 30 parts, Herba Euphorbiae supinae 35 parts, Caulis Polygoni Multiflori 25 parts, Fructus rubi tephrodis 24 parts, Cortex Cinnamomi 25 parts and Viola variegata 30 parts.
Wherein, in described medicine, the ratio of weight and number of each raw medicinal material can be preferably again: Herba Ecliptae 18 parts, Caulis Sargentodoxae 28 parts, Radix Gentianae Macrophyllae 30 parts, Herb Gynostemmae Pentaphylli 25 parts, Fructus Aurantii 17 parts, Nux Prinsepiae 20 parts, Testis et penis callorhini 17 parts, Chinese small iris 24 parts, Hippocampus 16 parts, Radix Angelicae Sinensis 27 parts, Rhizoma Sparganii 29 parts, Rhizoma Curcumae 24 parts, Rhizoma Smilacis 23 parts, Cortex Moutan 20 parts, Rhizoma Alismatis 24 parts, the Rhizoma Anemarrhenae 21 parts, flatstiped corydalis herb 17 parts, Cortex Phellodendri 22 parts, Cortex Lycii 24 parts, Herba Melastomatis Dodecandri 20 parts, Coniogramme japonica (Thunb.) Diels 30 parts, Pericarpium Citri Reticulatae 25 parts, Corm Brassicae caulorapae 22 parts, Rhizoma Cyperi 32 parts, Radix Melastomatis Sanguinei 21 parts, Radix Paeoniae Rubra 18 parts, Mirabilitum 23 parts, arrow leaf knotweed 30 parts, Herba Euphorbiae supinae 32 parts, Caulis Polygoni Multiflori 33 parts, Fructus rubi tephrodis 24 parts, Cortex Cinnamomi 27 parts and Viola variegata 29 parts.
Wherein, when the dosage form of described medicine is oral liquid, its preparation method comprises the following steps:
The first step, by Coniogramme japonica (Thunb.) Diels, Pericarpium Citri Reticulatae, Corm Brassicae caulorapae, Rhizoma Cyperi, Radix Melastomatis Sanguinei, Radix Paeoniae Rubra, Mirabilitum, arrow leaf knotweed, Herba Euphorbiae supinae, Caulis Polygoni Multiflori, Fructus rubi tephrodis, Cortex Cinnamomi and Viola variegata mixing, add relative to mixture 6 ~ 8 times amount determining alcohol be 90% ~ 95% alcohol reflux 2 ~ 3 times, each 3 ~ 5 hours, filter respectively, each time filtrate merges, and reclaims ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.37 ~ 1.39, for subsequent use;
Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 5 ~ 7 times of water gagings, boils 4 ~ 6 hours, and filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.32 ~ 1.36;
3rd step, the described mastic mixing that the first step, second step are obtained, 70 DEG C ~ 80 DEG C reduced vacuum dryings, get dry extract powder;
4th step, is added ethanol in the described dried cream powder that the 3rd step is obtained, and obtains containing alcohol mastic, and the described alcohol content containing alcohol mastic is 65% ~ 80%; Carry out chilling treatment, precipitation process, filtration treatment, recovery Ethanol Treatment by described successively containing alcohol mastic, obtain dealcoholysis mastic, wherein, the chilling treatment time is 24 ~ 48 hours, and refrigerated storage temperature is 3 DEG C ~ 6 DEG C;
5th step, adds cane sugar powder, active carbon by described dealcoholysis mastic, carries out heat treated, filtration treatment, dilution process successively, obtain semi-finished product; The weight ratio of described dealcoholysis mastic and described cane sugar powder is 1: 0.2 ~ 0.35; The weight ratio of described dealcoholysis mastic and described active carbon is 1: 0.003 ~ 0.005; The time of described heat treated is 70 ~ 90 minutes, and temperature is 150 DEG C ~ 180 DEG C;
6th step, the more described semi-finished product that the 5th step obtains are carried out filtration treatment, embedding process, sterilization treatment successively, obtain described medicine oral liquid finished product.
Wherein, when the dosage form of described medicine is ointment, its preparation method comprises the following steps:
The first step, is mixed in proportion each for described medicine raw medicinal material, is ground into 40 order ~ 60 object powder, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract, be ground into 100 order ~ 200 object powder;
Second step, stearic acid heating dissolved, remaining on temperature is 70 DEG C ~ 80 DEG C, obtains stearic acid liquid; In addition, hydroxide first, glycerol, ethyl hydroxybenzoate and distilled water are mixed in proportion, heating, maintains the temperature at 70 DEG C ~ 80 DEG C, obtains distilled water mixed liquor; Stearic acid liquid is slowly joined in distilled water mixed liquor, stirs cooling simultaneously, obtain substrate;
3rd step, joins the drug powder that the first step obtains in the substrate of second step acquisition and is also constantly ground to evenly, obtain ointment.
Wherein, when the dosage form of described medicine is capsule, its preparation method comprises the following steps:
The first step, is mixed in proportion each for described medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;
3rd step, adds Pulvis Talci, magnesium stearate successively in the micropowders that second step obtains, and carries out mixing process, obtains capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.15 ~ 0.5:0.15 ~ 0.5, incapsulate in housing by described capsule 's content, obtain capsule finished product.
The invention has the beneficial effects as follows: the present invention has vital energy regualting and blood circulation-promoting that effect of eliminating blood stasis and removing ecchymoses cures mainly qi stagnation and blood stasis type chloasma, have rapid-action, effective percentage is high, determined curative effect, treatment short treating period, have no side effect, the advantages such as price is low.
Detailed description of the invention
The traditional Chinese medical science is thought, liver is lost bar and reaches, mechanism of qi pent-up, strongly fragrant fire-transformation of a specified duration, cloudy blood of burning, and hematogenous blockage, can cause face qi-blood disharmony; Deficiency-weakness of spleen-QI, transporting is lost strong, and can not change spermatogenesis micro-, then QI and blood can not be moistened in face; Insufficiency of kidney-YANG, the pathological changes such as deficiency of kidney-essence all can cause face generation chloasma.
Therefore, the invention provides a kind of medicine for the treatment of qi stagnation and blood stasis type chloasma, wherein, following raw medicinal material is comprised: Herba Ecliptae, Caulis Sargentodoxae, Radix Gentianae Macrophyllae, Herb Gynostemmae Pentaphylli, Fructus Aurantii, Nux Prinsepiae, Testis et penis callorhini, Chinese small iris, Hippocampus, Radix Angelicae Sinensis, Rhizoma Sparganii, Rhizoma Curcumae, Rhizoma Smilacis, Cortex Moutan, Rhizoma Alismatis, the Rhizoma Anemarrhenae, flatstiped corydalis herb, Cortex Phellodendri, Cortex Lycii, Herba Melastomatis Dodecandri, Coniogramme japonica (Thunb.) Diels, Pericarpium Citri Reticulatae, Corm Brassicae caulorapae, Rhizoma Cyperi, Radix Melastomatis Sanguinei, Radix Paeoniae Rubra, Mirabilitum, arrow leaf knotweed, Herba Euphorbiae supinae, Caulis Polygoni Multiflori, Fructus rubi tephrodis, Cortex Cinnamomi and Viola variegata.
Wherein, the pharmacology of above-mentioned raw materials medical material is as follows:
Herb Gynostemmae Pentaphylli: sweet in the mouth, hardship, cold nature; Return lung meridian, spleen channel, kidney channel.Energy QI invigorating, calms the nerves, blood pressure lowering, heat-clearing and toxic substances removing, eliminating phlegm and stopping cough.After taking Herb Gynostemmae Pentaphylli, enterogastric peristalsis is accelerated, and it is long that appetite increases the resistance to time of hungering and thirst, and not only treats constipation but also control loose stool.Reaction that is excited to cerebral cortex and that suppress can keep suitable balance, has dual regulation to nervus centralis.There is excellent analgesia, sleeping, antitonic effect.In reduction myocardial wall anxiety, relax on the basis of cerebrovascular and peripheral vascular resistance, heart and brain vigor can be strengthened, strengthen coronary flow, relax arteriosclerosis, impel entirety to circulate more vigorous and smooth.Experiment proves, and the not rich Herb Gynostemmae Pentaphylli group that takes of diet, and and avoid meat and refuses to obey Herb Gynostemmae Pentaphylli group, make regular check on and compare, body inner bag is consolidated close with neutral fat content.Herb Gynostemmae Pentaphylli has benign transformed regulating action to body fat mass in human body as can be seen here.
Nux Prinsepiae: sweet, is slightly cold.Return Liver Channel.Nourishing the liver to improve visual acuity, wind-dispelling heat-dissipating.For conjunctival congestion and swelling pain, red and fester on the palpebral margin, the dark photophobia of order.1. " not Lu ": " be slightly cold, nontoxic." 2. " medical center bun is wanted ": " sweet salty, cold." enter liver, heart channel.1. " Thunder God concocts property of medicine solution ": " enter the heart, liver, spleen three warp." pathogenic wind expelling heat radiation, beneficial aquatic light.Three through all blood is also dirty, and blood obtains it and supports, then order disease is put down.All order diseases, at table, are worked as wind and heat dispersing, are suffered from a deficiency of the kidney at inner genus, insufficiency of blood, refreshing labor, should calm the nerves by kidney-replenishing blood-nourishing.Hypermetropia is that kidney water loses, and myopia is that fire is not enough.2. " jade seizes medicine solution ": " start with lunar lung, liver channel of foot-Jueyin." effect: dispel the wind, heat radiation, nourishing the liver, improving eyesight.Control conjunctival congestion and swelling pain, dim shy the moon, the rotten many tear of the corner of the eyes, epistaxis.Also trusted subordinate's pathogenic heat are controlled, stagnation of QI fullness and oppression sensation in the epigastrium due to accumulation of phlegm.Moderns are only with treating eye.
Testis et penis callorhini: salty in the mouth, hot in nature, returns liver.Warming the kidney tonifying YANG, benefit essence mends marrow.Control deficient impairment caused by overstrain, sexual impotence essence declines, premature ejaculation, waist knee flaccidity, trusted subordinate's pain.One, tonifying YANG YIN nourishing, kidney-supplementing liver-boosting, endocrine regulation.Its whip is put down, and enters liver the kidney invigorating.Be applicable to because of diseases such as sexual impotence, premature ejaculation, sexual disorder and the insomnia and dreamful sleep caused by the groan kidney deficiency such as damage of kidney-YIN, insufficiency of kidney-YANG, dizzy forgetful, soreness of waist and knee, neurasthenia and immunologic hypofunctions; Two, blood yiqi.Hemoglobin in Testis et penis callorhini and hemoglobin high, be applicable to blood deficiency gas weak person; Three, skin care skin Caring.Containing a large amount of viscous protein in Testis et penis callorhini, there is slow down aging, keep the function of elasticity of skin and moisture; Four, bone and muscle strengthening.Testis et penis callorhini is the kidney invigorating treasure, and kidney by force then can bone and muscle strengthening." Bencao Jingshu ": " deficiency of YIN heated and hectic fever due to YIN-deficiency chronic cough wait, and saltyly avoided.”
Hippocampus: Gan Wen.There is effect of kidney invigorating and YANG supporting, warm promoting blood circulation, tranquillizing and allaying excitement, mass dissipating and swelling eliminating, relaxing muscles and tendons and activating QI and blood in the collateral, relieving cough and asthma.Hippocampus is warm in nature supporing yang, can promoting the flow of QI-blood by warming the meridian, effect of invigorating blood circulation again, cure mainly suffer from a deficiency of the kidney, sexual impotence, the enuresis.Hippocampus is the famous and precious medicine that a kind of economic worth is higher, has the medicinal functions such as building body, kidney invigorating and YANG supporting, relaxing muscles and tendons and activating QI and blood in the collateral, anti-inflammatory analgetic, tranquillizing and allaying excitement, relieving cough and asthma, particularly more effective for the neural disease for the treatment of.Hippocampus, except mainly for the manufacture of except various synthetic drug, can also directly take to be healthy and strong and cure the disease.Hippocampus can strengthen mice anoxia enduring, reduces the activity of monoamine oxidase, MAO, reduces lipid peroxidation body content in vivo.In addition, various Hippocampus extract all has the effect of calcium channel blocker.By blocking Ca2+ influx, reach effect of neuroprotective unit.
Rhizoma Sparganii: acrid, bitter, warm, returns liver, spleen two warp, removing blood stasis circulation of qi promoting, removing food stagnancy pain relieving.Compendium of Material Medica: " Rhizoma Sparganii energy relieving stagnant and resolving masses, therefore all diseases can be controlled, its merit can be bordering on Rhizoma Cyperi and power is high, therefore difficult clothes for a long time." be applicable to kinds of tumors, as ovarian cancer, cervical cancer, hepatocarcinoma etc.In addition these product are also applicable to stagnation of QI and blood, abdominal part caking, hepatosplenomegaly, amenorrhea stomachache, food stagnation distending pain etc.The Rhizoma Sparganii decocting person that affects of isolated small intestines of rabbits motion is boiled 30min, make the decoct containing crude drug 75%, Rhizoma Sparganii decoct 0.2ml is added in 100ml Precerving liquid, observe the impact on intestine in vitro, experiment repetition 8 times, result shows, Rhizoma Sparganii can cause intestinal contraction to strengthen, tonicity raises, but its effect can by the atropine of variable concentrations institute antagonism.
Rhizoma Curcumae: pungent, bitter, temperature.Return liver, spleen channel.Removing blood stasis circulation of qi promoting, removing food stagnancy pain relieving.But warm concerted effort is comparatively large, can treat amenorrhea due to stagnation of blood stomachache, abdominal mass, gather.Can the pain relieving of circulation of qi promoting removing food stagnancy, for eating accumulation, breast abdominal distention is vexed has a pain.Also can removing blood stasis, women's amenorrhea, or the lump in the abdomen addiction block of phlegm-damp congestion condensation.Aromatic turmeric oil preparation has the growth of the multiple tumor strains such as the L615 leukemia of Mouse Ehrlich Carcinoma Cells, 615 mouse inbred liness and ascites hepatoma cells in vitro and obviously suppresses and destruction.
Cortex Moutan: bitter in the mouth, pungent, cold nature, enters the heart, liver, kidney channel.Have the effect of clearing away heat and cooling blood, promoting blood circulation to remove blood stasis, be mainly used in the treatment epidemic febrile disease pathogenic heat attacking blood system in febrile diseases, send out speckle, tell nosebleed, calentura later stage hot Fu Yin divides heating, deficiency of YIN osteopyrexia and fever, amenorrhea due to stagnation of blood, dysmenorrhea, carbuncle sore tumefacting virus, falls and flutter the card such as the pain of injury, beriberoid pyretic arthralgia.Be apt to purify the blood, and invigorate blood circulation, thus have effect of cool the blood dissipate blood stasis, make blood flow freely and not stay the stasis of blood, the absurd clearly and not row of heat in blood.Therefore to diseases such as intense heat in the blood, Liver and kidney hyperactivity of fire and stagnation of blood stasis, all rely on as key medicine." herbal classic ": " main cold and heat, apoplexy Chi Zong, convulsion, infantile convulsion pathogen, except the hard blood stasis of disease stays house the intestines and stomach, settling five organs, treat carbuncle skin ulcer." " Japan hanako materia medica ": " except pathogen, happy color, clearance natural fibre line of meat blood vessels, evacuation of pus, logical menstruation, disappear and flutter damage blood stasis, reuniting the fractured tendons and bones, except migratory arthralgia, fall tire lower eyelid, puerperal all cold and hot vim and vigour."。Compendium of Material Medica: " nourishing YIN to lower pathogenic fire separates speckle poison, throat, diuresis stasis.Descendant specially controls fire mutually with yellow tiller, does not know that the merit of Cortex Moutan more wins also.Red colored person's profit, the person of spending in vain mends, and people also seldom realizes, and should distinguish it." there is the effect of clearing away heat and cooling blood, promoting blood circulation to remove blood stasis, be mainly used in the treatment epidemic febrile disease pathogenic heat attacking blood system in febrile diseases, send out speckle, tell nosebleed, calentura later stage hot Fu Yin divides heating, deficiency of YIN osteopyrexia and fever, amenorrhea due to stagnation of blood, dysmenorrhea, carbuncle sore tumefacting virus, falls and flutter the card such as the pain of injury, beriberoid pyretic arthralgia.Be apt to purify the blood, and invigorate blood circulation, thus have effect of cool the blood dissipate blood stasis, make blood flow freely and not stay the stasis of blood, the absurd clearly and not row of heat in blood.Therefore to diseases such as intense heat in the blood, Liver and kidney hyperactivity of fire and stagnation of blood stasis, all rely on as key medicine.Cortex Moutan can increase coronary flow to the anesthetized dog heart, reduces cardiac output, reduces the effect of left room work done.The mice heating that paeonol oral disposition typhoid fever, paratyphoid vaccine cause has refrigeration function, and reduces normal mouse body temperature.
Rhizoma Alismatis: sweet in the mouth, light, cold in nature, enter kidney, urinary bladder channel, theory of Chinese medical science thinks that it is cold in nature, has promoting diuresis to eliminate damp pathogen, the lung that clears away heart-fire, rushes down effect of kidney fire.Be mainly used in insufficiency of the spleen retention of water-damp, the wet hydrosarca of spreading unchecked of water; The tired resistance of the heresy of diseases caused by retention of fluid phlegm-damp, what cause that clear YANG failing to ascend voiced sound do not fall is dizzy; The dysuria of damp invasion of lower energizer, red short puckery pain, and the card such as jaundice due to damp-heat.
Cortex Phellodendri: be the dry bark of rutaceae wampee or Cortex Phellodendri.The former practises title " Cortex Phellodendri ", and the latter practises title " Cortex Phellodendri ".Can be used as medicine, nature and flavor bitter cold, has heat clearing and damp drying, and pathogenic fire purging removes steams, effect of detoxification sore treatment.Cortex Phellodendri is distributed in the area such as Northeast China and North China each province, and happiness is grown among mountain area, assorted woods, and strong adaptability, is applicable to the cultivation of sun-drenched place, also can anti-severe cold.Cortex Phellodendri is common drug, and its cold in nature, bitter in the mouth, the effects such as tool heat clearing and damp drying, eliminating fire and detoxication, are usually used in damp-heat dysentery, jaundice, leucorrhea and the disease such as pyretic arthralgia, pyretic stranguria.Modern study shows, Cortex Phellodendri is containing the main component such as berberine, obacunone, and have the effect of antibacterial, convergence, antiinflammatory, to symptoms such as various skin noxious dampness, skin infection, effect is good." herbal classic is met former " is said: " Cortex Phellodendri, raw with falling excess-fire, processed with wine is controlled in YIN-fire scorching, and salt system controls the inferior the fire of Jiao, and processed with Rhizoma Zingiberis Recens controls middle burnt phlegm-fire, and Sucus Zingberis is fried and blackly controlled damp and hot, and black asthenic fire processed fried by salt wine, deficiency of YIN fire Sheng flushed complexion floating YANG, Radix Aconiti Lateralis Preparata juice system ".
Cortex Lycii: cold in nature, sweet in the mouth; Enter lung, liver, kidney channel." not Lu ": " main air wets, lower breast side of body gas, and exopathogenic heat is had a headache, and mends internal injury great Lao and to hiss suction, hard muscle, reinforcing YIN-essence, sharp intestine and small intestine, resistance to cold and summer-heat." " book on Chinese herbal medicine is stated ": " cures mainly deficient fever, alternate attacks of chills and fever, allly sees blood disorder, epistaxis, cough blood, and cough, breathe heavily, diseases due to endogenous heat of ZANG FU organs, apoplexy, dizzy, convulsion is chronic, lumbago, migratory arthralgia, beriberi, edema, and fidgets due to deficiency is throbbed with fear, forgetful, urinary obstruction, reddish and whitish turbid urine." removing heat from blood removes and steams, lung heat clearing pathogenic fire reducing.Cure mainly hectic fever due to deficiency of YIN, hectic fever due to YIN-deficiency night sweat, infantile malnutrition generates heat, and quench one's thirst, pulmonary cough is breathed heavily, and spits blood, epistaxis, hematuria.
Radix Gentianae Macrophyllae: pungent, bitter, is slightly cold.Return stomach warp, Liver Channel, gallbladder meridian.Eradicates rheumatism, relaxing muscles and tendons network, clearind deficient heat.For rheumatic arthralgia, the contracture of muscle arteries and veins, joint is ached, afternoon fever, and infantile malnutrition generates heat.Rheumatic arthralgia, the contracture of muscle arteries and veins, joint is ached, and all can apply by compatibility for a long time without inquiring about chills and fever is new.
Pericarpium Citri Reticulatae: nature and flavor are bitter, pungent, temperature.Return lung, spleen channel.There is regulating qi-flowing for strengthening spleen, the function of drying dampness to eliminate phlegm.Can be used for fullness in the epigastrium and chest, lack of appetite and vomiting, cough with copious phlegm.Therefore Pericarpium Citri Reticulatae has three major types effect, one is lead cold-evil in the heart, two broken stagnant gas, three strengthening the spleen stomaches.This three large on, Main Function is row QI of the spleen and stomach.The main transmitting and distributing the fluids of taste, therefore QI of the spleen and stomach is capable, can dry, spleen invigorating, reduce phlegm, therefore can say again, Pericarpium Citri Reticulatae temperature can support spleen, pungently can be amusing, bitter can spleen invigorating.Due to the main row QI of the spleen and stomach of Pericarpium Citri Reticulatae, taste are located in middle Jiao, and the gas of middle Jiao passes through, and the gas of three Jiao is also sprung up thereupon.Three Jiao are the organ in charge of water circulation, and current water liquid, accompanies with wetting phase; Again for hiding mansion outside mansion, upper and the heart, lung, lower and liver, kidney.So the effect of Pericarpium Citri Reticulatae can wide and all Zang Fu, wet throughout whole body.Say from lung, then pungent loose lung qi, hardship lets out lung qi, temperatureization cold, can control abundant expectoration cough with asthma, and gas is stopped up food and stopped; Say from the heart, then pungent happy gas, hardship lets out heart-fire, and warm removing dampness is turbid, can control irritable feverish sensation in the chest, and the implication sound of vomiting is smelly; Say from liver, then pungent loose stagnation of liver-QI, liver-fire falls in hardship, warming for eliminaring cold-damp, so its can treating the liver be strongly fragrant heat, drink is stopped eating stagnant; Say from kidney, then pungent profit kidney is dry, and hardship is let out kidney and wet, gentle kidney qi, so it can control life fire deficiency, and indigestion.
Rhizoma Cyperi: nature and flavor: pungent, micro-hardship, sweet, flat.Enter liver, tri-jiao channel.To regulate the flow of vital energy resolving depression; Menstruction regulating and pain relieving; Antiabortive.Main distending pain over the hypochondrium; Mammary swelling is educated; Hernia pain; Menoxenia; Gastral cavity abdomen feeling of fullness pain; Belch acid regurgitation, vomiting and nausea; Abdominal pain during menstruation; Bleeding not during menses; Frequent fetal movement.Compendium of Material Medica is said: " gas of Rhizoma Cyperi is flat and do not tremble with fear, fragrant and can alter, and how pungent its taste is can fall apart, and micro-hardship can be fallen, micro-sweet energy with "." Amplification on Materia Medica addendum ": " Rhizoma Cyperi, must soak with urine of baby boys, all vim and vigour medicines must with it, cause edema caused by disorder of QI and hemopoietic, the justice of this Yin grows while yang is generating is also." resolving depression of can regulating the flow of vital energy; Menstruction regulating and pain relieving; Antiabortive.Main distending pain over the hypochondrium; Mammary swelling is educated; Hernia pain; Menoxenia; Gastral cavity abdomen feeling of fullness pain; Belch acid regurgitation, vomiting and nausea; Abdominal pain during menstruation; Bleeding not during menses; Frequent fetal movement.For stagnation of QI due to depression of the liver, breast, the side of body, abdominal distention, dyspepsia, breast gastral cavity painful abdominal mass is vexed, and colic of cold type is suffered from abdominal pain, distending pain of the breast, menoxenia, amenorrhea dysmenorrhea.
Herba Ecliptae: cool in nature, sweet in the mouth acid.There is effect of cooling blood for hemostasis, the kidney invigorating and essence nourishing, be usually used in treatment haematemesis, epistaxis, hematuria, have blood in stool, the disease such as dysentery, knife injury are hemorrhage, early whitening of beard and hair, diphtheria, stranguria with turbid discharge, leukorrhagia, pudendum pruritus due to damp pathogen.Tang Materia Medica: " main dysentery.Acupuncture skin ulcer is sent out, and big vast blood can not the person of stopping apply it; Juice is coated with sends out an eyebrow, raw speed and numerous." " classifying herbal ": " hemostasis, the kidney invigorating, annealing, detumescence.Control pouring, collapse." there is effect of cooling blood for hemostasis, the kidney invigorating and essence nourishing, be usually used in treatment haematemesis, epistaxis, hematuria, have blood in stool, the disease such as dysentery, knife injury are hemorrhage, early whitening of beard and hair, diphtheria, stranguria with turbid discharge, leukorrhagia, pudendum pruritus due to damp pathogen.Apply hemorrhage place with Fructus seu radix camptothecae acuminatae (Fructus Camptothecae Acuminatae) blade of grass powder and oppress a little, having good haemostatic effect.
Caulis Polygoni Multiflori: sweet, micro-, bitter, flat; Enter the heart, spleen, kidney, Liver Channel.There is effect of tranquilizing and blood nourishing, dispelling wind and removing obstruction in the collateral, cure mainly the diseases such as deficiency of YIN insufficiency of blood, restlessness of asrhenia type and insomnia, rheumatic arthralgia, itchy skin eruption.Caulis Polygoni Multiflori has nourishing blood to tranquillize the mind effect, is main for the insomnia caused by deficiency of YIN insufficiency of blood.The existing effect of nourishing blood of Caulis Polygoni Multiflori, also can tonneau meridians, and control blood deficiency malasia, Caulis Polygoni Multiflori is decocted soup washout and controlled itchy skin eruption, has certain itching-relieving action.Added in grain by Caulis Polygoni Multiflori, manufacture experimently into the health food containing Caulis Polygoni Multiflori composition, its effect, effect can compare favourably with Radix Polygoni Multiflori food, eat for a long time, can tranquilizing by nourishing the heart, dredging collateral dispel the wind, smooth stool, aid digestion, useful and harmless to human body.
The Rhizoma Anemarrhenae: bitter in the mouth, sweet, cold in nature, enters lung, stomach, kidney channel, has relieving restlessness of purging heat, the effect of nourshing Yin and drynsessmoistening prescription, clearing away lung-heat to relieve cough, and cure mainly fever caused by exogenous pathogenic factors, high heat is irritated, lung-heat type cough, and interior-heat such as to be quenched one's thirst at the symptom; Its bitter cold matter is moistened, and property sedimentation can heat clearing away, can promote the production of body fluid again, kindly controls warm pathogenic factor and enters edema caused by disorder of QI, intenseness of heat impairment of body fluid; Also diabetes is used for the treatment of; Phlegm-heat obstructing in the lung and breathing heavily, xeropulmonary cough, expectorant is few unfavorable; Hyperactivity of fire caused by deficiency of YIN, the symptoms such as hyperactivity of deficient fire.
Caulis Sargentodoxae: nature and flavor: bitter, flat.Gui Jing: return large intestine, Liver Channel.Cure mainly: heat-clearing and toxic substances removing, invigorate blood circulation, dispel the wind.For abdominalgia with intestinal abscess, amenorrhea dysmenorrhea, rheumatic arthralgia, tumbling and swelling.
Radix Aconiti Vaginati: nature and flavor: " Guizhou folk medicine ": " warm in nature, acrid in the mouth." cure mainly: control cough with asthma, menoxenia, traumatic injury.1. " Guizhou folk medicine ": " promoting blood flow to regulate menstruation, pain relieving." 2. control traumatic injury, reduce phlegm, cough-relieving is breathed heavily.Innominate toxic swelling is wiped in external.
Carapax Trionycis: nature and flavor: salty, is slightly cold.Gui Jing: return liver, kidney channel.Curing mainly: nourishing YIN for suppressing the hyperactive YANG, hard masses softening and resolving, bringing down a fever except steaming.For fever due to yin deficiency, consumptive fever hectic fever due to YIN-deficiency, stirring-up of pathogenic wind in the interior resulting from deficiency, amenorrhea , WEIJIA, chronic malaria malaria with splenomegaly.
Fructus Aurantii: nature and flavor: bitter, pungent, sour, temperature.Gui Jing: return spleen, stomach warp.Cure mainly: regulating the flow of QI to ease the stomach, the stagnant relieving distension of row.For the breast side of body stagnation of QI, distension pain, accumulation of food in the stomach and intes tine due to indigestion, stops in phlegm retention; Gastroptosis, proctoptosis, sub-official's prolapsus.
Radix Melastomatis Sanguinei: nature and flavor: bitter in the mouth; Puckery; Cool in nature.Gui Jing: return spleen; Liver Channel.Cure mainly: removing toxic substances pain relieving; Promoting regeneration of the tissue and arresting bleeding.Main eruptive disease stomachache; Dysentery; Have blood in stool; Menorrhagia; Furuncle; Treating swelling and pain by traumatic injury; Traumatic hemorrhage.
Chinese small iris: nature and flavor: sweet, light, cool.Cure mainly: heat-clearing and toxic substances removing, diuresis, hemostasis.
Arrow leaf knotweed: nature and flavor: sour, puckery is flat.Cure mainly: expelling wind and removing dampness, heat-clearing and toxic substances removing.For rheumatic arthritis, venom.
Herba Melastomatis Dodecandri: nature and flavor: sweet, puckery is flat.Cure mainly: heat-clearing and toxic substances removing, expelling wind and removing dampness, tonifying blood and arresting bleeding.For preventing the lonely inflammation of epidemic cerebrospinal, enteritis, dysentery, lung abscess, pelvic inflammatory disease, metrorrhagia, anemia, leucorrhea, lumbago and skelalgia, rheumatic ostalgia, traumatic hemorrhage, venom.
Radix Angelicae Sinensis: nature and flavor: sweet, acrid, warm.Gui Jing: return liver, the heart, spleen channel.Cure mainly: enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.For blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.Radix Angelicae Sinensis (processed with wine) promoting blood circulation to restore menstrual flow.For amenorrhea dysmenorrhea, rheumatic arthralgia, injury from falling down.
Cortex Cinnamomi: nature and flavor: pungent, sweet, hot greatly.Gui Jing: return kidney, spleen, the heart, Liver Channel.Cure mainly: mend fire supporing yang, let the fire back to its origin, dispersing cold for relieving pain, promoting blood circulation to restore menstrual flow.For sexual impotence, cold womb, chills and pain of the waist and kness, suffers from a deficiency of the kidney and breathes heavily, dizziness due to yang deficiency, conjunctival congestion pharyngalgia, trusted subordinate's cold type of pain, and deficiency and coldness is vomited and diarrhoea, colic of cold type, renal mass, amenorrhea, dysmenorrhea.
Rhizoma Smilacis: nature and flavor: 1. " Traditional Chinese Medicine in Sichuan will ": " bitter, flat, nontoxic." 2. " choosing of Yunnan Chinese herbal medicine ": " is sweet light, flat." return through: " Traditional Chinese Medicine in Sichuan will ": " enters liver, stomach, kidney three warp." curing mainly: 1. " Traditional Chinese Medicine in Sichuan will ": " wind-damp dispelling, divides pure and impure, sharp joint, separates sore.Dispelling the wind and dampness pathogens pain, waist knee joint arthralgia pain.Stranguria with turbid discharge and syphilis malignant boil." 2. " choosing of Yunnan Chinese herbal medicine ": " expelling wind and removing dampness, treating stranguria, diuretic, antiinflammatory, removing toxic substances.Treating rheumatic arthritis, urinary system infection, chronic gastritis, menoxenia, furuncle."
Flatstiped corydalis herb: nature and flavor: cold in nature, bitter in the mouth.Cure mainly: antipyretic analgesic.Control gastritis, Peptic Ulcers, dysentery, sciatica.
Fructus rubi tephrodis: nature and flavor: sweet acid, temperature.1. " herbal classic ": " acid, flat." 2. " not Lu ": " be salty, nontoxic." 3. " feeding habits book on Chinese herbal medicine ": " sweet acid, slight fever." cure mainly: invigorating the liver and kidney, urine reducing.Zhiduo County urinates, the vertigo.
Mirabilitum: nature and flavor: arduous salty, cold.1. " herbal classic ": " bitter in the mouth, cold." 2. " not Lu ": " be pungent, Great Cold, nontoxic." 3. " property of medicine opinion ": " bitter in the mouth is salty." return through: enter stomach, large intestine channel.
Corm Brassicae caulorapae: nature and flavor: Gan Xin is cool.Cure mainly: control stranguria with turbid discharge, stool hematochezia, toxic swelling, sinusitis with purulent discharge.
Herba Euphorbiae supinae: nature and flavor: " will planted by Tianmu Mountains of Zhejiang Province medicine ": " pungent, flat." cure mainly: hemostasis, clearing away damp-heat, lactogenesis.To harness the Yellow River subcutaneous ulcer, have loose bowels, infantile malnutrition, dysentery, hematuria, metrorrhagia, traumatic hemorrhage, milk is few, carbuncle sore tumefacting virus.1. " will planted by Tianmu Mountains of Zhejiang Province medicine ": " loose blood hemostasis, diuresis, promoting lactation.Control carbuncle malignant boil, it is hemorrhage that Jin Ren flutters damage, dysentery, metrorrhagia." 2. " Chinese herbal medicine is commonly used in Shanghai ": " stops blooding, diuresis, and stomach invigorating, invigorates blood circulation, removing toxic substances.Harness the Yellow River subcutaneous ulcer, dysentery, diarrhoea, urinary tract infection, has blood in stool, hematuria, metrorrhagia, bleeding hemorrhoids, infantile malnutrition, treating swelling and pain by traumatic injury, woman's galactostasis, venom, head sore, skin sore, wound hemorrhage."
Viola variegata: nature and flavor: sweet in the mouth, cool in nature.Cure mainly: heat-clearing and toxic substances removing; Cooling blood for hemostasis.Main carbuncle pyogenic infections from tumour or sore; Wound hemorrhage.
Radix Paeoniae Rubra: nature and flavor: bitter, is slightly cold.Gui Jing: return Liver Channel.Cure mainly: clearing away heat and cooling blood, eliminating stasis to stop pain.For maculae caused by violent heat pathogen, hematemesis and epistaxis, conjunctival congestion and swelling pain, hypochondriac pain due to stagnation of liverQI, amenorrhea dysmenorrhea, lump in the abdomen is suffered from abdominal pain, injury from falling down, carbuncle skin infection.
Wherein, in described medicine, the ratio of weight and number of each raw medicinal material can be preferably: Herba Ecliptae 10 ~ 25 parts, Caulis Sargentodoxae 10 ~ 35 parts, Radix Gentianae Macrophyllae 10 ~ 30 parts, Herb Gynostemmae Pentaphylli 15 ~ 35 parts, Fructus Aurantii 9 ~ 20 parts, Nux Prinsepiae 12 ~ 24 parts, Testis et penis callorhini 11 ~ 21 parts, Chinese small iris 10 ~ 30 parts, Hippocampus 14 ~ 28 parts, Radix Angelicae Sinensis 15 ~ 35 parts, Rhizoma Sparganii 12 ~ 30 parts, Rhizoma Curcumae 10 ~ 28 parts, Rhizoma Smilacis 12 ~ 26 parts, Cortex Moutan 14 ~ 30 parts, Rhizoma Alismatis 15 ~ 28 parts, the Rhizoma Anemarrhenae 10 ~ 25 parts, flatstiped corydalis herb 15 ~ 30 parts, Cortex Phellodendri 15 ~ 25 parts, Cortex Lycii 14 ~ 28 parts, Herba Melastomatis Dodecandri 10 ~ 25 parts, Coniogramme japonica (Thunb.) Diels 10 ~ 35 parts, Pericarpium Citri Reticulatae 11 ~ 27 parts, Corm Brassicae caulorapae 10 ~ 28 parts, Rhizoma Cyperi 15 ~ 35 parts, Radix Melastomatis Sanguinei 13 ~ 25 parts, Radix Paeoniae Rubra 10 ~ 25 parts, Mirabilitum 14 ~ 26 parts, arrow leaf knotweed 10 ~ 30 parts, Herba Euphorbiae supinae 17 ~ 35 parts, Caulis Polygoni Multiflori 15 ~ 36 parts, Fructus rubi tephrodis 13 ~ 28 parts, Cortex Cinnamomi 14 ~ 30 parts and Viola variegata 13 ~ 33 parts.
Wherein, in described medicine, the ratio of weight and number of each raw medicinal material can also be preferably: Herba Ecliptae 15 ~ 24 parts, Caulis Sargentodoxae 13 ~ 32 parts, Radix Gentianae Macrophyllae 14 ~ 30 parts, Herb Gynostemmae Pentaphylli 15 ~ 28 parts, Fructus Aurantii 11 ~ 20 parts, Nux Prinsepiae 14 ~ 22 parts, Testis et penis callorhini 13 ~ 19 parts, Chinese small iris 13 ~ 28 parts, Hippocampus 15 ~ 22 parts, Radix Angelicae Sinensis 16 ~ 32 parts, Rhizoma Sparganii 16 ~ 29 parts, Rhizoma Curcumae 15 ~ 26 parts, Rhizoma Smilacis 14 ~ 25 parts, Cortex Moutan 17 ~ 23 parts, Rhizoma Alismatis 16 ~ 25 parts, the Rhizoma Anemarrhenae 13 ~ 21 parts, flatstiped corydalis herb 17 ~ 20 parts, Cortex Phellodendri 16 ~ 22 parts, Cortex Lycii 16 ~ 24 parts, Herba Melastomatis Dodecandri 13 ~ 21 parts, Coniogramme japonica (Thunb.) Diels 12 ~ 32 parts, Pericarpium Citri Reticulatae 13 ~ 25 parts, Corm Brassicae caulorapae 15 ~ 26 parts, Rhizoma Cyperi 17 ~ 34 parts, Radix Melastomatis Sanguinei 16 ~ 23 parts, Radix Paeoniae Rubra 11 ~ 20 parts, Mirabilitum 18 ~ 24 parts, arrow leaf knotweed 14 ~ 30 parts, Herba Euphorbiae supinae 18 ~ 35 parts, Caulis Polygoni Multiflori 15 ~ 34 parts, Fructus rubi tephrodis 13 ~ 26 parts, Cortex Cinnamomi 15 ~ 30 parts and Viola variegata 13 ~ 31 parts.
Wherein, in described medicine, the ratio of weight and number of each raw medicinal material can be preferably again: Herba Ecliptae 22 parts, Caulis Sargentodoxae 30 parts, Radix Gentianae Macrophyllae 28 parts, Herb Gynostemmae Pentaphylli 15 parts, Fructus Aurantii 17 parts, Nux Prinsepiae 14 parts, Testis et penis callorhini 15 parts, Chinese small iris 20 parts, Hippocampus 22 parts, Radix Angelicae Sinensis 32 parts, Rhizoma Sparganii 29 parts, Rhizoma Curcumae 24 parts, Rhizoma Smilacis 23 parts, Cortex Moutan 21 parts, Rhizoma Alismatis 16 parts, the Rhizoma Anemarrhenae 13 parts, flatstiped corydalis herb 20 parts, Cortex Phellodendri 19 parts, Cortex Lycii 16 parts, Herba Melastomatis Dodecandri 15 parts, Coniogramme japonica (Thunb.) Diels 32 parts, Pericarpium Citri Reticulatae 25 parts, Corm Brassicae caulorapae 24 parts, Rhizoma Cyperi 32 parts, Radix Melastomatis Sanguinei 21 parts, Radix Paeoniae Rubra 20 parts, Mirabilitum 24 parts, arrow leaf knotweed 30 parts, Herba Euphorbiae supinae 35 parts, Caulis Polygoni Multiflori 32 parts, Fructus rubi tephrodis 24 parts, Cortex Cinnamomi 30 parts and Viola variegata 31 parts.
Wherein, in described medicine, the ratio of weight and number of each raw medicinal material can be preferably again: Herba Ecliptae 17 parts, Caulis Sargentodoxae 32 parts, Radix Gentianae Macrophyllae 18 parts, Herb Gynostemmae Pentaphylli 25 parts, Fructus Aurantii 14 parts, Nux Prinsepiae 22 parts, Testis et penis callorhini 19 parts, Chinese small iris 24 parts, Hippocampus 22 parts, Radix Angelicae Sinensis 32 parts, Rhizoma Sparganii 26 parts, Rhizoma Curcumae 24 parts, Rhizoma Smilacis 20 parts, Cortex Moutan 21 parts, Rhizoma Alismatis 17 parts, the Rhizoma Anemarrhenae 13 parts, flatstiped corydalis herb 17 parts, Cortex Phellodendri 22 parts, Cortex Lycii 24 parts, Herba Melastomatis Dodecandri 21 parts, Coniogramme japonica (Thunb.) Diels 30 parts, Pericarpium Citri Reticulatae 23 parts, Corm Brassicae caulorapae 24 parts, Rhizoma Cyperi 32 parts, Radix Melastomatis Sanguinei 22 parts, Radix Paeoniae Rubra 20 parts, Mirabilitum 24 parts, arrow leaf knotweed 30 parts, Herba Euphorbiae supinae 35 parts, Caulis Polygoni Multiflori 25 parts, Fructus rubi tephrodis 24 parts, Cortex Cinnamomi 25 parts and Viola variegata 30 parts.
Wherein, in described medicine, the ratio of weight and number of each raw medicinal material can be preferably again: Herba Ecliptae 18 parts, Caulis Sargentodoxae 28 parts, Radix Gentianae Macrophyllae 30 parts, Herb Gynostemmae Pentaphylli 25 parts, Fructus Aurantii 17 parts, Nux Prinsepiae 20 parts, Testis et penis callorhini 17 parts, Chinese small iris 24 parts, Hippocampus 16 parts, Radix Angelicae Sinensis 27 parts, Rhizoma Sparganii 29 parts, Rhizoma Curcumae 24 parts, Rhizoma Smilacis 23 parts, Cortex Moutan 20 parts, Rhizoma Alismatis 24 parts, the Rhizoma Anemarrhenae 21 parts, flatstiped corydalis herb 17 parts, Cortex Phellodendri 22 parts, Cortex Lycii 24 parts, Herba Melastomatis Dodecandri 20 parts, Coniogramme japonica (Thunb.) Diels 30 parts, Pericarpium Citri Reticulatae 25 parts, Corm Brassicae caulorapae 22 parts, Rhizoma Cyperi 32 parts, Radix Melastomatis Sanguinei 21 parts, Radix Paeoniae Rubra 18 parts, Mirabilitum 23 parts, arrow leaf knotweed 30 parts, Herba Euphorbiae supinae 32 parts, Caulis Polygoni Multiflori 33 parts, Fructus rubi tephrodis 24 parts, Cortex Cinnamomi 27 parts and Viola variegata 29 parts.
Wherein, when the dosage form of described medicine is oral liquid, its preparation method comprises the following steps:
The first step, by Coniogramme japonica (Thunb.) Diels, Pericarpium Citri Reticulatae, Corm Brassicae caulorapae, Rhizoma Cyperi, Radix Melastomatis Sanguinei, Radix Paeoniae Rubra, Mirabilitum, arrow leaf knotweed, Herba Euphorbiae supinae, Caulis Polygoni Multiflori, Fructus rubi tephrodis, Cortex Cinnamomi and Viola variegata mixing, add relative to mixture 6 ~ 8 times amount determining alcohol be 90% ~ 95% alcohol reflux 2 ~ 3 times, each 3 ~ 5 hours, filter respectively, each time filtrate merges, and reclaims ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.37 ~ 1.39, for subsequent use;
Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 5 ~ 7 times of water gagings, boils 4 ~ 6 hours, and filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.32 ~ 1.36;
3rd step, the described mastic mixing that the first step, second step are obtained, 70 DEG C ~ 80 DEG C reduced vacuum dryings, get dry extract powder;
4th step, is added ethanol in the described dried cream powder that the 3rd step is obtained, and obtains containing alcohol mastic, and the described alcohol content containing alcohol mastic is 65% ~ 80%; Carry out chilling treatment, precipitation process, filtration treatment, recovery Ethanol Treatment by described successively containing alcohol mastic, obtain dealcoholysis mastic, wherein, the chilling treatment time is 24 ~ 48 hours, and refrigerated storage temperature is 3 DEG C ~ 6 DEG C;
5th step, adds cane sugar powder, active carbon by described dealcoholysis mastic, carries out heat treated, filtration treatment, dilution process successively, obtain semi-finished product; The weight ratio of described dealcoholysis mastic and described cane sugar powder is 1: 0.2 ~ 0.35; The weight ratio of described dealcoholysis mastic and described active carbon is 1: 0.003 ~ 0.005; The time of described heat treated is 70 ~ 90 minutes, and temperature is 150 DEG C ~ 180 DEG C;
6th step, the more described semi-finished product that the 5th step obtains are carried out filtration treatment, embedding process, sterilization treatment successively, obtain described medicine oral liquid finished product.
Wherein, when the dosage form of described medicine is ointment, its preparation method comprises the following steps:
The first step, is mixed in proportion each for described medicine raw medicinal material, is ground into 40 order ~ 60 object powder, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract, be ground into 100 order ~ 200 object powder;
Second step, stearic acid heating dissolved, remaining on temperature is 70 DEG C ~ 80 DEG C, obtains stearic acid liquid; In addition, hydroxide first, glycerol, ethyl hydroxybenzoate and distilled water are mixed in proportion, heating, maintains the temperature at 70 DEG C ~ 80 DEG C, obtains distilled water mixed liquor; Stearic acid liquid is slowly joined in distilled water mixed liquor, stirs cooling simultaneously, obtain substrate;
3rd step, joins the drug powder that the first step obtains in the substrate of second step acquisition and is also constantly ground to evenly, obtain ointment.
Wherein, when the dosage form of described medicine is capsule, its preparation method comprises the following steps:
The first step, is mixed in proportion each for described medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;
3rd step, adds Pulvis Talci, magnesium stearate successively in the micropowders that second step obtains, and carries out mixing process, obtains capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.15 ~ 0.5:0.15 ~ 0.5, incapsulate in housing by described capsule 's content, obtain capsule finished product.
Embodiment 1 oral liquid
The manufacturing process of oral liquid of the present invention is: get Herba Ecliptae 220g, Caulis Sargentodoxae 300g, Radix Gentianae Macrophyllae 280g, Herb Gynostemmae Pentaphylli 150g, Fructus Aurantii 170g, Nux Prinsepiae 140g, Testis et penis callorhini 150g, Chinese small iris 200g, Hippocampus 220g, Radix Angelicae Sinensis 320g, Rhizoma Sparganii 290g, Rhizoma Curcumae 240g, Rhizoma Smilacis 230g, Cortex Moutan 210g, Rhizoma Alismatis 160g, Rhizoma Anemarrhenae 130g, flatstiped corydalis herb 200g, Cortex Phellodendri 190g, Cortex Lycii 160g, Herba Melastomatis Dodecandri 150g, Coniogramme japonica (Thunb.) Diels 320g, Pericarpium Citri Reticulatae 250g, Corm Brassicae caulorapae 240g, Rhizoma Cyperi 320g, Radix Melastomatis Sanguinei 210g, Radix Paeoniae Rubra 200g, Mirabilitum 240g, arrow leaf knotweed 300g, Herba Euphorbiae supinae 350g, Caulis Polygoni Multiflori 320g, Fructus rubi tephrodis 240g, Cortex Cinnamomi 300g and Viola variegata 310g,
The first step, by Coniogramme japonica (Thunb.) Diels, Pericarpium Citri Reticulatae, Corm Brassicae caulorapae, Rhizoma Cyperi, Radix Melastomatis Sanguinei, Radix Paeoniae Rubra, Mirabilitum, arrow leaf knotweed, Herba Euphorbiae supinae, Caulis Polygoni Multiflori, Fructus rubi tephrodis, Cortex Cinnamomi and Viola variegata mixing, add relative to mixture 7 times amount determining alcohol be 95% alcohol reflux 2 times, each 5 hours, filter respectively, each time filtrate merges, and reclaims ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.38, for subsequent use;
Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 5 times of water gagings, boils 5 hours, and filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.35;
3rd step, the described mastic mixing that the first step, second step are obtained, 80 DEG C of reduced vacuum dryings, get dry extract powder;
4th step, is added ethanol in the described dried cream powder that the 3rd step is obtained, and obtains containing alcohol mastic, and the described alcohol content containing alcohol mastic is 75%; Carry out chilling treatment, precipitation process, filtration treatment, recovery Ethanol Treatment by described successively containing alcohol mastic, obtain dealcoholysis mastic, wherein, the chilling treatment time is 48 hours, and refrigerated storage temperature is 6 DEG C;
5th step, adds cane sugar powder, active carbon by described dealcoholysis mastic, carries out heat treated, filtration treatment, dilution process successively, obtain semi-finished product; The weight ratio of described dealcoholysis mastic and described cane sugar powder is 1: 0.3; The weight ratio of described dealcoholysis mastic and described active carbon is 1: 0.004; The time of described heat treated is 80 minutes, and temperature is 170 DEG C;
6th step, the more described semi-finished product that the 5th step obtains are carried out filtration treatment, embedding process, sterilization treatment successively, obtain described medicine oral liquid finished product.
Embodiment 2 ointment
The manufacturing process of ointment of the present invention is: get Herba Ecliptae 170g, Caulis Sargentodoxae 320g, Radix Gentianae Macrophyllae 180g, Herb Gynostemmae Pentaphylli 250g, Fructus Aurantii 140g, Nux Prinsepiae 220g, Testis et penis callorhini 190g, Chinese small iris 240g, Hippocampus 220g, Radix Angelicae Sinensis 320g, Rhizoma Sparganii 260g, Rhizoma Curcumae 240g, Rhizoma Smilacis 200g, Cortex Moutan 210g, Rhizoma Alismatis 170g, Rhizoma Anemarrhenae 130g, flatstiped corydalis herb 170g, Cortex Phellodendri 220g, Cortex Lycii 240g, Herba Melastomatis Dodecandri 210g, Coniogramme japonica (Thunb.) Diels 300g, Pericarpium Citri Reticulatae 230g, Corm Brassicae caulorapae 240g, Rhizoma Cyperi 320g, Radix Melastomatis Sanguinei 220g, Radix Paeoniae Rubra 200g, Mirabilitum 240g, arrow leaf knotweed 300g, Herba Euphorbiae supinae 350g, Caulis Polygoni Multiflori 250g, Fructus rubi tephrodis 240g, Cortex Cinnamomi 250g and Viola variegata 300g,
The first step, is mixed in proportion each for described medicine raw medicinal material, is ground into 60 object powder, and adding relative to the determining alcohol of mixture quality 3 times is the ethanol of 90%, reflux 3 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 905% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 2 times again, reflux 2 hours, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract, be ground into 200 object powder;
Second step, stearic acid heating dissolved, remaining on temperature is 80 DEG C, obtains stearic acid liquid; In addition, hydroxide first, glycerol, ethyl hydroxybenzoate and distilled water are mixed in proportion, heating, maintains the temperature at 70 DEG C, obtains distilled water mixed liquor; Stearic acid liquid is slowly joined in distilled water mixed liquor, stirs cooling simultaneously, obtain substrate;
3rd step, joins the drug powder that the first step obtains in the substrate of second step acquisition and is also constantly ground to evenly, obtain ointment.
Embodiment 3 capsule
The manufacturing process of capsule of the present invention is: get Herba Ecliptae 180g, Caulis Sargentodoxae 280g, Radix Gentianae Macrophyllae 300g, Herb Gynostemmae Pentaphylli 250g, Fructus Aurantii 170g, Nux Prinsepiae 200g, Testis et penis callorhini 170g, Chinese small iris 240g, Hippocampus 160g, Radix Angelicae Sinensis 270g, Rhizoma Sparganii 290g, Rhizoma Curcumae 240g, Rhizoma Smilacis 230g, Cortex Moutan 200g, Rhizoma Alismatis 240g, Rhizoma Anemarrhenae 210g, flatstiped corydalis herb 170g, Cortex Phellodendri 220g, Cortex Lycii 240g, Herba Melastomatis Dodecandri 200g, Coniogramme japonica (Thunb.) Diels 300g, Pericarpium Citri Reticulatae 250g, Corm Brassicae caulorapae 220g, Rhizoma Cyperi 320g, Radix Melastomatis Sanguinei 210g, Radix Paeoniae Rubra 180g, Mirabilitum 230g, arrow leaf knotweed 300g, Herba Euphorbiae supinae 320g, Caulis Polygoni Multiflori 330g, Fructus rubi tephrodis 240g, Cortex Cinnamomi 270g and Viola variegata 290g,
The first step, is mixed in proportion each for described medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 3 times is the ethanol of 90%, reflux 2 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1.5 times again, reflux 2 hours, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 2 hours, pulverize, sieve, obtain 400 object micropowders;
3rd step, adds Pulvis Talci, magnesium stearate successively in the micropowders that second step obtains, and carries out mixing process, obtains capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.3:0.5, incapsulate in housing by described capsule 's content, obtain capsule finished product.
Acute toxicity test: application NIH mice 40, SPF level, male and female half and half, body weight 18 ~ 25g, carries out acute toxicity test.Mice is divided into two groups at random, often organizes 20, i.e. matched group and administration group, fasting 12 hours before experiment; Capsule prepared by embodiments of the invention 3 is dissolved in water, (concentration is 5.74g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg(and unit dosage form is 28.7 crude drugs/kg), matched group gives normal saline, administration in a day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage capsule LD50>28.7 crude drug/kg of the present invention, every day, maximum dosage-feeding was 57.4 crude drugs/kg/ day.Clinical drug dosage of the present invention be 4.6g crude drug/day/people, adult body weight in 60KG, average dosage is 0.077g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 21g) oral administration gavage medicine of the present invention is 745 times of quantity.Therefore Acute toxicity of the present invention is low, clinical drug safety.
Long term toxicity test: by the Oral Liquid On Mice of the embodiment of the present invention 1 by 6.43,15.72 and 36.41g crude drug/kg continuous use 16 weeks (1.0ml/100g body weight, every day 2 times) and drug withdrawal after 4 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of medicine of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 16 weeks and drug withdrawal are after 4 weeks, and Organs of Mice is all without obviously changing.Illustrate that medicine of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.
Acute skin irritation is tested: these product are according to 6.3 joints in Ministry of Public Health " cosmetics health specification " (2002) Part II " skin irritation/corrosion test ", male 4 of Japan large ear rabbit, body weight 2kg ~ 3kg, according to the method for above-mentioned " acute dermal toxicity test ", then the ointment 0.5g of Example 2 directly to spread upon on the left of animal on skin (opposite side in contrast), adopt blocking test, 4 hours application time, tested material is remained with warm water washing after off-test, 1h after removing tested material, 24h, 48h and 72h observes the dermoreaction of the tested district of animal and check plot respectively, top average is " 0 ", judge that these product are to animal skin nonirritant.
Hypersensitive test: get healthy albino guinea-pig 18, body weight 250-300g, male and female dual-purpose, reject both sides dorsal body setae before test, every side 3 × 3cm, is divided into test group, blank group (substrate) and positive controls at random.Positive controls DNFB, sensitization 1% concentration, excites and uses 0.1% concentration.The ointment getting the embodiment of the present invention 2 is applied to unhairing district, back, the next day 1 time, totally 3 times.In latter 14 days of last contact, smear the ointment 0.1g of embodiment 2 at back the same area, at once observe after removing medicine after 6h, and in 24,48,72h observes with or without anaphylaxis.Blank group and positive controls excite by same method and contact and observe.Result of the test: namely positive controls animal skin occurs localized erythema and slight edema in sensitization after 1 hour, within 24 hours, symptoms of allergic increases the weight of, and have scleroma to be formed, sensitization rate is 100%, all there is not any symptoms of allergic in test group and blank treated animal skin, sensitization rate is 0%.
Clinical data:
Case selection: fetch the 288 routine qi stagnation and blood stasis type patient with chloasma coming from the court department of dermatologry patient, be women; 20 ~ 45 years old age, mid-face type 70 example, lower jaw type 97 example, buccal type 121 example; 28 years old mean age; Medical history 7 months ~ 18 months; 288 routine patients are divided into oral liquid treatment group, ointment treatment group, capsule treatment group and matched group at random, each experimental group 72 people, and each experimental group patient age, the state of an illness etc. are no difference of science of statistics all, has comparability.
Diagnostic criteria:
1. facial light brown to dark brown, well-defined patch, usually symmetrical, NIP performance and squama.2. without obvious subjective symptoms.3. women is multiple, after mainly occurring in adolescence.4. the state of an illness can have seasonality, and the Chang Xiachong winter is light.5. the pigmentation that other diseases (as jaw portion Fuscocaeruleus, the pigmentosa photochemical shape lichen planus of Richl melanosis agent etc.) causes is got rid of.
Therapeutic Method:
Oral liquid treatment group: use oral liquid prepared by the embodiment of the present invention 1, every day 3 times, 30ml/ time every 30 days is 1 course for the treatment of;
Ointment treatment group: use ointment prepared by the embodiment of the present invention 2, every day 2 times sooner or later respectively once, every 30 days is a course for the treatment of;
Capsule treatment group: use capsule prepared by the embodiment of the present invention 3, every day 3 times, each 2 every 30 days is a course for the treatment of;
Matched group: take foster flourish spot-removing ointment, every day 2 times sooner or later respectively once, every 30 days is 1 course for the treatment of;
The standard of curative effect evaluation: draft with reference to " Chinese medical disease Standardization of diagnosis and curative effect ".Cure: 1. naked eyes to disappear > 90% depending on mottle area, and facial skin is normal skin tone; 2. decline after point system calculating treatment index >=0.8; 3. pigmented area skin image measures efficacy evaluation unit ID >=55.Effective: 1. naked eyes to disappear > 60% depending on mottle area, and color obviously shoals; 2. decline after point system calculating treatment index >=0.5; 3. pigmented area skin image measures efficacy evaluation unit ID >=15.Take a turn for the better: 1. naked eyes to disappear > 30% depending on mottle area, lighter; 2. decline after point system calculating treatment index >=0.3; 3. pigmented area skin image measures efficacy evaluation unit ID >=5.Invalid: 1. naked eyes to disappear < 30% depending on mottle area, color change is not obvious; 2. decline after point system calculating treatment index≤0; 3. pigmented area skin image measures efficacy evaluation unit ID >=1.
Therapeutic outcome:
See table 1 and table 2, as can be seen from Table 1, adopt Drug therapy qi stagnation and blood stasis type chloasma of the present invention, relative to conventional medicament on therapeutic effect, there is significant improvement; As can be seen from Table 2, adopt Drug therapy qi stagnation and blood stasis type chloasma of the present invention, relative to conventional medicament, treatment the course for the treatment of on significantly shorten.
After each group of table 1 treats 4 courses for the treatment of respectively, Clinical efficacy comparison is routine
Group Number of cases Cure number Effective number Good revolution Invalid number Total effective rate (%)
Oral liquid treatment group 72 32 34 6 0 100%
Ointment treatment group 72 33 35 4 0 100%
Capsule treatment group 72 31 32 8 1 98.6%
Matched group 72 15 20 27 10 86.1%
Table 2 Four composition do not treat after 4 courses for the treatment of cure, effective and improvement number and time comparative example (%)
Group Number of cases 1st course for the treatment of 2nd course for the treatment of 3rd course for the treatment of 4th course for the treatment of
Oral solutions treatment group 72 15(20.8%) 18(25%) 19(26.4%) 20(27.8%)
Ointment treatment group 72 16(22.2%) 17(23.6%) 18(25%) 21(29.2%)
Capsule treatment group 71 14(19.7%) 18(24.6%) 18(25.4%) 21(29.6%)
Matched group 62 6(9.7%) 8(12.9%) 9(14.5%) 39(62.9%)
According to the clinical statistics in above table, medicine provided by the invention have rapid-action, effective percentage is high, determined curative effect, safety are high, have no side effect; Treatment group is cured simultaneously, 215 examples of effective and improvement number and matched group is cured, the effective and 62 routine follow-up of patients 1 year half that takes a turn for the better, result is added up, in oral liquid treatment group 72 example, healing 32 example and effective 34 examples are all without recurrence, 1 case relapsed in 6 examples of improvement, and relapse rate is 1.4%; In ointment treatment group 72 example, 4 examples of healing 33 example, effective 35 examples, improvement are all without recurring, and relapse rate is 0%; Cure 31 examples in capsule treatment group 72 example without recurrence, 1 case relapsed in effective 32 examples, recur 2 examples in 8 examples of improvement, relapse rate is 4.2%; Matched group is cured, effective and improvement number 62 example, recurs 6 examples, recurs 8 examples in effective 20 routine patients, recur 11 examples, relapse rate 40.3% in 27 examples of improvement in 15 routine patients of healing; Above-mentioned recurrence refers to that patient outcomes reaches healing, effective or after taking a turn for the better, and does not occur the light brown and situation such as dark brown, well-defined patch at 1 year half septum reset of following up a case by regular visits to.
Model case: Wang, women, 25 years old, there were indefinite light brown and dark brown, well-defined patch in bilateral buccal and nose position, form not of uniform size.Hope through trial inspection and the traditional Chinese medical science, hear, ask, cut and be diagnosed as qi stagnation and blood stasis type chloasma further.Use the ointment of Medications Example 2 of the present invention, every day 2 times, sooner or later respectively once, treat and substantially cure for 2 months, continue medication two weeks and cure, follow up a case by regular visits to and do not recur for 1 year half, facial skin is normal skin tone.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims (9)

1. treat the medicine of qi stagnation and blood stasis type chloasma for one kind, it is characterized in that, comprise following raw medicinal material: Herba Ecliptae, Caulis Sargentodoxae, Radix Gentianae Macrophyllae, Herb Gynostemmae Pentaphylli, Fructus Aurantii, Nux Prinsepiae, Testis et penis callorhini, Chinese small iris, Hippocampus, Radix Angelicae Sinensis, Rhizoma Sparganii, Rhizoma Curcumae, Rhizoma Smilacis, Cortex Moutan, Rhizoma Alismatis, the Rhizoma Anemarrhenae, flatstiped corydalis herb, Cortex Phellodendri, Cortex Lycii, Herba Melastomatis Dodecandri, Coniogramme japonica (Thunb.) Diels, Pericarpium Citri Reticulatae, Corm Brassicae caulorapae, Rhizoma Cyperi, Radix Melastomatis Sanguinei, Radix Paeoniae Rubra, Mirabilitum, arrow leaf knotweed, Herba Euphorbiae supinae, Caulis Polygoni Multiflori, Fructus rubi tephrodis, Cortex Cinnamomi and Viola variegata.
2. the medicine for the treatment of qi stagnation and blood stasis type chloasma according to claim 1, it is characterized in that, in described medicine, the ratio of weight and number of each raw medicinal material is: Herba Ecliptae 10 ~ 25 parts, Caulis Sargentodoxae 10 ~ 35 parts, Radix Gentianae Macrophyllae 10 ~ 30 parts, Herb Gynostemmae Pentaphylli 15 ~ 35 parts, Fructus Aurantii 9 ~ 20 parts, Nux Prinsepiae 12 ~ 24 parts, Testis et penis callorhini 11 ~ 21 parts, Chinese small iris 10 ~ 30 parts, Hippocampus 14 ~ 28 parts, Radix Angelicae Sinensis 15 ~ 35 parts, Rhizoma Sparganii 12 ~ 30 parts, Rhizoma Curcumae 10 ~ 28 parts, Rhizoma Smilacis 12 ~ 26 parts, Cortex Moutan 14 ~ 30 parts, Rhizoma Alismatis 15 ~ 28 parts, the Rhizoma Anemarrhenae 10 ~ 25 parts, flatstiped corydalis herb 15 ~ 30 parts, Cortex Phellodendri 15 ~ 25 parts, Cortex Lycii 14 ~ 28 parts, Herba Melastomatis Dodecandri 10 ~ 25 parts, Coniogramme japonica (Thunb.) Diels 10 ~ 35 parts, Pericarpium Citri Reticulatae 11 ~ 27 parts, Corm Brassicae caulorapae 10 ~ 28 parts, Rhizoma Cyperi 15 ~ 35 parts, Radix Melastomatis Sanguinei 13 ~ 25 parts, Radix Paeoniae Rubra 10 ~ 25 parts, Mirabilitum 14 ~ 26 parts, arrow leaf knotweed 10 ~ 30 parts, Herba Euphorbiae supinae 17 ~ 35 parts, Caulis Polygoni Multiflori 15 ~ 36 parts, Fructus rubi tephrodis 13 ~ 28 parts, Cortex Cinnamomi 14 ~ 30 parts and Viola variegata 13 ~ 33 parts.
3. the medicine for the treatment of qi stagnation and blood stasis type chloasma according to claim 1 and 2, it is characterized in that, in described medicine, the ratio of weight and number of each raw medicinal material is: Herba Ecliptae 15 ~ 24 parts, Caulis Sargentodoxae 13 ~ 32 parts, Radix Gentianae Macrophyllae 14 ~ 30 parts, Herb Gynostemmae Pentaphylli 15 ~ 28 parts, Fructus Aurantii 11 ~ 20 parts, Nux Prinsepiae 14 ~ 22 parts, Testis et penis callorhini 13 ~ 19 parts, Chinese small iris 13 ~ 28 parts, Hippocampus 15 ~ 22 parts, Radix Angelicae Sinensis 16 ~ 32 parts, Rhizoma Sparganii 16 ~ 29 parts, Rhizoma Curcumae 15 ~ 26 parts, Rhizoma Smilacis 14 ~ 25 parts, Cortex Moutan 17 ~ 23 parts, Rhizoma Alismatis 16 ~ 25 parts, the Rhizoma Anemarrhenae 13 ~ 21 parts, flatstiped corydalis herb 17 ~ 20 parts, Cortex Phellodendri 16 ~ 22 parts, Cortex Lycii 16 ~ 24 parts, Herba Melastomatis Dodecandri 13 ~ 21 parts, Coniogramme japonica (Thunb.) Diels 12 ~ 32 parts, Pericarpium Citri Reticulatae 13 ~ 25 parts, Corm Brassicae caulorapae 15 ~ 26 parts, Rhizoma Cyperi 17 ~ 34 parts, Radix Melastomatis Sanguinei 16 ~ 23 parts, Radix Paeoniae Rubra 11 ~ 20 parts, Mirabilitum 18 ~ 24 parts, arrow leaf knotweed 14 ~ 30 parts, Herba Euphorbiae supinae 18 ~ 35 parts, Caulis Polygoni Multiflori 15 ~ 34 parts, Fructus rubi tephrodis 13 ~ 26 parts, Cortex Cinnamomi 15 ~ 30 parts and Viola variegata 13 ~ 31 parts.
4. the medicine of the treatment qi stagnation and blood stasis type chloasma according to any one of claim 1-3, it is characterized in that, in described medicine, the ratio of weight and number of each raw medicinal material is: Herba Ecliptae 22 parts, Caulis Sargentodoxae 30 parts, Radix Gentianae Macrophyllae 28 parts, Herb Gynostemmae Pentaphylli 15 parts, Fructus Aurantii 17 parts, Nux Prinsepiae 14 parts, Testis et penis callorhini 15 parts, Chinese small iris 20 parts, Hippocampus 22 parts, Radix Angelicae Sinensis 32 parts, Rhizoma Sparganii 29 parts, Rhizoma Curcumae 24 parts, Rhizoma Smilacis 23 parts, Cortex Moutan 21 parts, Rhizoma Alismatis 16 parts, the Rhizoma Anemarrhenae 13 parts, flatstiped corydalis herb 20 parts, Cortex Phellodendri 19 parts, Cortex Lycii 16 parts, Herba Melastomatis Dodecandri 15 parts, Coniogramme japonica (Thunb.) Diels 32 parts, Pericarpium Citri Reticulatae 25 parts, Corm Brassicae caulorapae 24 parts, Rhizoma Cyperi 32 parts, Radix Melastomatis Sanguinei 21 parts, Radix Paeoniae Rubra 20 parts, Mirabilitum 24 parts, arrow leaf knotweed 30 parts, Herba Euphorbiae supinae 35 parts, Caulis Polygoni Multiflori 32 parts, Fructus rubi tephrodis 24 parts, Cortex Cinnamomi 30 parts and Viola variegata 31 parts.
5. the medicine of the treatment qi stagnation and blood stasis type chloasma according to any one of claim 1-4, it is characterized in that, in described medicine, the ratio of weight and number of each raw medicinal material is: Herba Ecliptae 17 parts, Caulis Sargentodoxae 32 parts, Radix Gentianae Macrophyllae 18 parts, Herb Gynostemmae Pentaphylli 25 parts, Fructus Aurantii 14 parts, Nux Prinsepiae 22 parts, Testis et penis callorhini 19 parts, Chinese small iris 24 parts, Hippocampus 22 parts, Radix Angelicae Sinensis 32 parts, Rhizoma Sparganii 26 parts, Rhizoma Curcumae 24 parts, Rhizoma Smilacis 20 parts, Cortex Moutan 21 parts, Rhizoma Alismatis 17 parts, the Rhizoma Anemarrhenae 13 parts, flatstiped corydalis herb 17 parts, Cortex Phellodendri 22 parts, Cortex Lycii 24 parts, Herba Melastomatis Dodecandri 21 parts, Coniogramme japonica (Thunb.) Diels 30 parts, Pericarpium Citri Reticulatae 23 parts, Corm Brassicae caulorapae 24 parts, Rhizoma Cyperi 32 parts, Radix Melastomatis Sanguinei 22 parts, Radix Paeoniae Rubra 20 parts, Mirabilitum 24 parts, arrow leaf knotweed 30 parts, Herba Euphorbiae supinae 35 parts, Caulis Polygoni Multiflori 25 parts, Fructus rubi tephrodis 24 parts, Cortex Cinnamomi 25 parts and Viola variegata 30 parts.
6. the medicine of the treatment qi stagnation and blood stasis type chloasma according to any one of claim 1-4, it is characterized in that, in described medicine, the ratio of weight and number of each raw medicinal material is: Herba Ecliptae 18 parts, Caulis Sargentodoxae 28 parts, Radix Gentianae Macrophyllae 30 parts, Herb Gynostemmae Pentaphylli 25 parts, Fructus Aurantii 17 parts, Nux Prinsepiae 20 parts, Testis et penis callorhini 17 parts, Chinese small iris 24 parts, Hippocampus 16 parts, Radix Angelicae Sinensis 27 parts, Rhizoma Sparganii 29 parts, Rhizoma Curcumae 24 parts, Rhizoma Smilacis 23 parts, Cortex Moutan 20 parts, Rhizoma Alismatis 24 parts, the Rhizoma Anemarrhenae 21 parts, flatstiped corydalis herb 17 parts, Cortex Phellodendri 22 parts, Cortex Lycii 24 parts, Herba Melastomatis Dodecandri 20 parts, Coniogramme japonica (Thunb.) Diels 30 parts, Pericarpium Citri Reticulatae 25 parts, Corm Brassicae caulorapae 22 parts, Rhizoma Cyperi 32 parts, Radix Melastomatis Sanguinei 21 parts, Radix Paeoniae Rubra 18 parts, Mirabilitum 23 parts, arrow leaf knotweed 30 parts, Herba Euphorbiae supinae 32 parts, Caulis Polygoni Multiflori 33 parts, Fructus rubi tephrodis 24 parts, Cortex Cinnamomi 27 parts and Viola variegata 29 parts.
7. the preparation method of the medicine of the treatment qi stagnation and blood stasis type chloasma according to any one of claim 1-4, is characterized in that, when the dosage form of described medicine is oral liquid, its preparation method comprises the following steps:
The first step, by Coniogramme japonica (Thunb.) Diels, Pericarpium Citri Reticulatae, Corm Brassicae caulorapae, Rhizoma Cyperi, Radix Melastomatis Sanguinei, Radix Paeoniae Rubra, Mirabilitum, arrow leaf knotweed, Herba Euphorbiae supinae, Caulis Polygoni Multiflori, Fructus rubi tephrodis, Cortex Cinnamomi and Viola variegata mixing, add relative to mixture 6 ~ 8 times amount determining alcohol be 90% ~ 95% alcohol reflux 2 ~ 3 times, each 3 ~ 5 hours, filter respectively, each time filtrate merges, and reclaims ethanol, being concentrated into 70 DEG C of relative densities is the mastic of 1.37 ~ 1.39, for subsequent use;
Second step, is mixed in proportion surplus stock medical material, adds relative to mixture 5 ~ 7 times of water gagings, boils 4 ~ 6 hours, and filter, being concentrated into 70 DEG C of relative densities is the mastic of 1.32 ~ 1.36;
3rd step, the described mastic mixing that the first step, second step are obtained, 70 DEG C ~ 80 DEG C reduced vacuum dryings, get dry extract powder;
4th step, is added ethanol in the described dried cream powder that the 3rd step is obtained, and obtains containing alcohol mastic, and the described alcohol content containing alcohol mastic is 65% ~ 80%; Carry out chilling treatment, precipitation process, filtration treatment, recovery Ethanol Treatment by described successively containing alcohol mastic, obtain dealcoholysis mastic, wherein, the chilling treatment time is 24 ~ 48 hours, and refrigerated storage temperature is 3 DEG C ~ 6 DEG C;
5th step, adds cane sugar powder, active carbon by described dealcoholysis mastic, carries out heat treated, filtration treatment, dilution process successively, obtain semi-finished product; The weight ratio of described dealcoholysis mastic and described cane sugar powder is 1: 0.2 ~ 0.35; The weight ratio of described dealcoholysis mastic and described active carbon is 1: 0.003 ~ 0.005; The time of described heat treated is 70 ~ 90 minutes, and temperature is 150 DEG C ~ 180 DEG C;
6th step, the more described semi-finished product that the 5th step obtains are carried out filtration treatment, embedding process, sterilization treatment successively, obtain described medicine oral liquid finished product.
8. the preparation method of the medicine of the treatment qi stagnation and blood stasis type chloasma according to any one of claim 1-4, is characterized in that, when the dosage form of described medicine is ointment, its preparation method comprises the following steps:
The first step, is mixed in proportion each for described medicine raw medicinal material, is ground into 40 order ~ 60 object powder, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract, be ground into 100 order ~ 200 object powder;
Second step, stearic acid heating dissolved, remaining on temperature is 70 DEG C ~ 80 DEG C, obtains stearic acid liquid; In addition, hydroxide first, glycerol, ethyl hydroxybenzoate and distilled water are mixed in proportion, heating, maintains the temperature at 70 DEG C ~ 80 DEG C, obtains distilled water mixed liquor; Stearic acid liquid is slowly joined in distilled water mixed liquor, stirs cooling simultaneously, obtain substrate;
3rd step, joins the drug powder that the first step obtains in the substrate of second step acquisition and is also constantly ground to evenly, obtain ointment.
9. the preparation method of the medicine of the treatment qi stagnation and blood stasis type chloasma according to any one of claim 1-4, is characterized in that, when the dosage form of described medicine is capsule, its preparation method comprises the following steps:
The first step, is mixed in proportion each for described medicine raw medicinal material, and adding relative to the determining alcohol of mixture quality 2 ~ 4 times is the ethanol of 85 ~ 95%, reflux 1 ~ 3 hour, extracts, and filters acquisition first extracting solution; It is the ethanol of 85 ~ 95% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 3 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;
Second step, is placed on the dry cream that the first step obtains in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 300 order ~ 400 object micropowders;
3rd step, adds Pulvis Talci, magnesium stearate successively in the micropowders that second step obtains, and carries out mixing process, obtains capsule 's content; Described micropowders, magnesium stearate and talcous weight ratio are 100: 0.15 ~ 0.5:0.15 ~ 0.5, incapsulate in housing by described capsule 's content, obtain capsule finished product.
CN201510118295.7A 2015-03-18 2015-03-18 Medicine for treating Qi-stagnation and blood stasis type chloasma and preparation method thereof Withdrawn CN104689240A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104998097A (en) * 2015-06-26 2015-10-28 吴强 Pharmaceutical composition for treating syndrome of blood stasis and preparation method thereof
CN107875055A (en) * 2017-11-29 2018-04-06 璧电健 Harvest application of the fruit in the skin care item for whitening anti-acne are prepared in ground

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1733141A (en) * 2005-08-17 2006-02-15 师宇 New preparation for curing chloasma and acne
CN101129789A (en) * 2007-08-29 2008-02-27 张秀丽 Orally taken traditional Chinese medicine composition for treating chloasma

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1733141A (en) * 2005-08-17 2006-02-15 师宇 New preparation for curing chloasma and acne
CN101129789A (en) * 2007-08-29 2008-02-27 张秀丽 Orally taken traditional Chinese medicine composition for treating chloasma

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104998097A (en) * 2015-06-26 2015-10-28 吴强 Pharmaceutical composition for treating syndrome of blood stasis and preparation method thereof
CN107875055A (en) * 2017-11-29 2018-04-06 璧电健 Harvest application of the fruit in the skin care item for whitening anti-acne are prepared in ground

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