CN102614462A - Traditional Chinese medicine composition for treating coronary heart disease and preparation method thereof - Google Patents

Abstract

The invention discloses a traditional Chinese medicine composition for treating coronary heart disease, which is prepared from the following raw material medicines in parts by weight: 6-15 parts of radix curcumae, 20-45 parts of barley malt, 2-6 parts of dalbergia wood, 6-15 parts of radix ophiopogonis, 12-18 parts of mother-of-pearl, 2-8 parts of agilawood, 9-25 parts of polygonum cuspidatum, 3-9 parts of platycodon grandiflorum, 2-6 parts of dragon's blood, 6-12 parts of donkey-hide gelatin, 5-12 parts of radix polygonati officinalis, 2-6 parts of American ginseng, 20-45 parts of astragalus membranaceus, 2-6 parts of saffron, 20-45 parts of salvia miltiorrhiza, 20. The excellent effects of the invention are also shown in: the selected materials are traditional Chinese medicine materials, and have no toxic or side effect; the formula completely accords with the traditional Chinese medicine principle and the physical and psychological characteristics of heart disease patients, and on the premise of the general principle, different formulas and different functions can be provided according to different groups of people. The medicine source is easy to obtain, the cost of the medicinal materials is low, and the burden of a patient can be relieved.

Description

Traditional Chinese medicine composition for treating coronary heart disease and preparation method thereof

technical field

The invention relates to the field of traditional Chinese medicine, in particular to a traditional Chinese medicine composition for treating coronary heart disease and a preparation method thereof.

Background technique

Coronary atherosclerotic heart disease (hereinafter referred to as coronary heart disease) is a heart disease caused by myocardial ischemia and hypoxia due to selenium-like atherosclerosis. And more than 95% of myocardial infarction is mostly developed from coronary heart disease, and the mortality rate of acute myocardial infarction is very high, mostly at 30% to 40%. It is a common disease that seriously threatens human life and health.

Coronary heart disease generally belongs to the categories of "chest pain", "jue heart pain" and "true pain" in traditional Chinese medicine. As early as in the "Huangdi Neijing", there is a record: "Heartache, pain in the chest, fullness of hypochondriac, pain in the hypochondriac, and pain between the back and blade." Another example is "Lingshu · Jue Disease", which says: "The heart hurts, the hands and feet Green solstice, the heartache is very serious. Sooner or later, you will die sooner or later." It is quite similar to angina pectoris and myocardial infarction. Zhang Zhongjing in the Han Dynasty further made a series of pulse syndrome descriptions in chapters such as "Synopsis of the Golden Chamber Chest Obstruction, Cardiac Pain, Shortness of Breath, Syndrome and Treatment of Pulse Syndrome", and put forward more systematic prescriptions. Such as "chest pain, wheezing and coughing, chest and back pain, shortness of breath, deep and late pulse at the cunkou, close the small tight number, Gualou Xiebai Baijiu Decoction"; Lou Xiebai Pinellia Decoction is the main one." Physicians of all dynasties have made full use of syndrome differentiation and prescriptions on this basis, and have accumulated a whole set of clinical experience in the prevention and treatment of coronary heart disease with traditional Chinese medicine in long-term medical practice.

The earliest clinical article on coronary heart disease in modern Chinese medicine was found in 1955, and it was proposed that this disease is equivalent to "chest pain" and "true pain" in traditional Chinese medicine. In the 1950s, case presentations were the main focus, with little clinical discussion and basic research. In the 1960s, clinical data gradually increased, and the etiology and pathogenesis, treatment rules, syndrome differentiation, and treatment prescriptions of the disease were elaborated, and preliminary curative effects were achieved, but basic research was still scarce; until the 1970s, clinical data and theoretical discussions Significantly increased, and the continuous holding of national academic conferences has promoted the development of research work and continuously improved the curative effect. Traditional Chinese medicine is not only used to prevent and treat angina pectoris, but also to rescue acute myocardial infarction. During this period, more clinical experience was summed up, and the rules of syndrome and treatment were explored. Treatment methods include syndrome differentiation, agreed prescription, unilateral prescription, acupuncture, massage, etc. The treatment is to promote blood circulation and remove blood stasis, unblock yang and relieve numbness, aromatize and warm, nourish qi, nourish yin and activate blood, replenish qi and activate blood, strengthen body and kidney, etc. In terms of syndrome differentiation, it is unanimously recognized that most of them belong to the mixed syndrome of deficiency and excess. Traditional Chinese medicine forms have evolved from decoctions to tablets, ointments, pills, granules, aerosols and injections, especially quick-acting preparations for relieving angina pectoris and Chinese medicine injections for dilating blood vessels, which have greatly improved the clinical value of Chinese medicine in the treatment of coronary heart disease. Combined traditional Chinese and western medicine rescue acute myocardial infarction reduces the fatality rate from 30% to 40% to about 12%. In terms of basic research, it has been found that activating blood circulation and removing blood stasis and blood-activating drugs can increase coronary flow, reduce myocardial oxygen consumption, inhibit platelet aggregation, anticoagulant and thrombolysis, and protect ischemic myocardium. Since the 1980s, although not too many new drugs and methods have been discovered, a lot of work has been done to further affirm the curative effect of existing prescriptions, study pharmacological effects and analyze active ingredients. For example, from the aspects of blood rheology, microcirculation and cardiac function tests, the mechanism of action of the therapy of promoting blood circulation and removing blood stasis was explored, and the research on anti-atherosclerosis was carried out.

The Chinese patent document of publication number CN 1498645A (application number 02148326.4) discloses a kind of Chinese medicine capsule and its manufacture method for treating cerebral thrombosis sequelae and coronary heart disease, and this Chinese medicine capsule is made of earthworm 15-20 grams, earthworm 15-20 25-30 grams of scorpion, 25-30 grams of centipede, 15-20 grams of white aconite, 15-20 grams of white snake, 15-20 grams of Gastrodia elata, 15-20 grams of ganoderma lucidum, 15-20 grams of silkworm, 25 grams of leech -30 grams, Zhijiazhu 20-30 grams, Musk 10-15 grams, Red Ginseng 15-0 grams, Curcuma 15-20 grams, Chuanxiong 15-20 grams, Salvia miltiorrhiza 25-30 grams, Yuanhu 15-20 grams composition. The Chinese patent literature with publication number CN 101524521A (application number 200810101486.2) discloses a Chinese medicine composition for treating coronary heart disease, which consists of Radix Glycyrrhizae, Polygonatum Polygonatum, Radix Paeoniae Alba, Radix Acanthae Radix, Radix Radix Radix Radix Radix Radix Radix Polygonatum, Radix Codonopsis, Accumulation, Acupuncture, etc. Dried ginger, gallinacea, cassia twig, raw land, bupleurum, donkey-hide gelatin, Fangji, Chuan Shao, sand ginseng, motherwort, angelica, sunburned astragalus and/or pharmaceutically acceptable carriers. The Chinese patent document of authorized announcement number CN1970069 (application number 200610170280.6) discloses a Chinese medicine pill for treating coronary heart disease, which is based on astragalus, rehmannia glutinosa, angelica, salvia miltiorrhiza, chuanxiong, mulberry, melon wilt, corydalis, peony, nine knots Calamus, Spatholobus, Polygonatum, Black sesame, Cuscuta, Atractylodes macrocephala, Curcuma, Shouwu, Epimedium, Suanzaoren, Schisandra, Ejiao, Ganoderma lucidum, Poria, Sanleng, Curcuma, Ophiopogon japonicus, Oyster, Codonopsis, Sandalwood, licorice and other 30 kinds of Chinese herbal medicines are used as raw materials, which are prepared by crushing and adding honey.

In a word, traditional Chinese medicine has achieved good curative effect in the treatment of this disease, but there are still some problems: clinically, the quick-acting vasodilator effect on acute blood supply insufficiency is not ideal enough, the curative effect on improving electrocardiogram needs to be improved, and the effect on the prevention and treatment of coronary heart disease Predisposing factors, such as hypertension, hyperlipidemia, and diabetes need to be studied simultaneously, and the curative effect on arrhythmias such as premature beats and atrial fibrillation in coronary heart disease needs to be further improved.

Contents of the invention

Aiming at the deficiencies of the prior art, the object of the present invention is to provide a traditional Chinese medicine composition for treating coronary heart disease which is simple to prepare, convenient to take, easy to carry, and easy to take for a long time, and a preparation method thereof. The traditional Chinese medicine composition has definite curative effect and no toxic and side effects.

Technical scheme of the present invention is:

The traditional Chinese medicine composition for treating myocardial infarction is prepared from the following raw materials, all in parts by weight: Curcuma 6-15, barley malt 20-45, Jiangxiang 2-6, Ophiopogon japonicus 6-15, mother-of-pearl 12-18 , Agarwood 2-8, Polygonum cuspidatum 9-25, Campanulaceae 3-9, Dracaena 2-6, Donkey-hide gelatin 6-12, Polygonatum 5-12, American ginseng 2-6, Astragalus 20-45, Saffron 2-6, Salvia 20-45, Trichosanthes 20-45, Musk 0.03-0.1.

In the preferred scheme, turmeric 9-12, barley malt 25-40, jiangxiang 3-5, radix radix 9-12, mother of pearl 14-16, agarwood 3-6, knotweed 12-20, bellflower 4-6, Blood jellyfish 3-5, donkey-hide gelatin 8-10, polygonatum 6-10, American ginseng 3-5, astragalus 25-40, saffron 3-5, salvia miltiorrhiza 25-40, melon 25-40, musk 0.05-0.08.

More preferably, turmeric 10, barley malt 30, radix 4, Ophiopogon japonicus 10, mother-of-pearl 15, agarwood 4, knotweed 16, bellflower 5, blood 4, donkey-hide gelatin 9, polygonatum 8, American ginseng 4, astragalus 35, Saffron 4, Salvia 35, Trichosanthes 35, Musk 0.06.

The present invention also provides a preparation method for making the aforementioned traditional Chinese medicine composition into pharmaceutically acceptable water, powder, tablet or capsule.

The preparation method of described water preparation is:

(1) Grind turmeric, barley malt, balsamic, Ophiopogon japonicus, mother-of-pearl, agarwood, knotweed, bellflower, dried blood, donkey-hide gelatin, Polygonatum odoratum, American ginseng, astragalus, saffron, salvia miltiorrhiza and Trichosanthes, and pass through 120- 140 mesh sieve (preferably 130 mesh sieve), get fine powder;

(2) Mix the fine powder obtained in step (1) evenly, place it in a transparent bag, and soak it in cold boiled water with a temperature of 20-40°C (preferably 30°C) for 6-8 hours (preferably 7 hours), and the water consumption is 3-4 times (preferably 3.5 times) of the weight of the fine powder;

(3) Heat to boiling for 0.6-1.2 hours (preferably 0.8-1.0 hours), then take out the transparent bag, and concentrate the obtained liquid to 1/2-1/3 of the original volume to obtain a concentrated solution;

(4) Grinding the musk, adding it to the concentrated solution obtained in step (3), and aseptically encapsulating it to obtain the Chinese medicine composition water.

The preparation method of the powder is as follows: crush each raw material through a 60-100 mesh sieve (preferably a 80-85 mesh sieve) to obtain the traditional Chinese medicine composition powder.

The preparation method of the tablet is: the powder of the traditional Chinese medicine composition obtained in claim 6 is measured according to 0.2-0.3g/tablet (preferably 0.25g/tablet), and pressed into a round or other form of tablet according to the processing and preparation method of the tablet dosage form.

The preparation method of the tablet is as follows: the powder of the traditional Chinese medicine composition obtained in claim 6 is measured according to 0.2-0.3 g/grain (preferably 0.25 g/grain), and processed into a capsule dosage form according to the processing and preparation method of the capsule.

The invention also provides the application of the traditional Chinese medicine composition in the preparation of medicines for treating myocardial infarction, myocardial necrosis and angina pectoris.

The pharmacology of main Chinese medicine raw material used in the present invention is as follows:

Mother of pearl: nature and flavor: salty, cold. Return through: return liver, heart channel. Efficacy: calming the liver and suppressing yang, calming convulsions and improving eyesight. Indications: For headache, dizziness, irritability and insomnia, liver heat and red eyes, liver deficiency and dizziness. "Chinese Medical Dictionary": This substance (mother of pearl) enters both the heart and liver meridians, which is different from that of Shicai Ming but enters the liver meridian, so it is necessary for people with mental illness.

Agarwood: nature and flavor: pungent, bitter, slightly warm. Return through: return spleen, stomach, kidney channel. Efficacy: promoting qi and relieving pain, warming middle-JIAO to stop vomiting, invigorating qi and relieving asthma. Indications: It is used for chest and abdomen distension and pain, stomach cold, vomiting and hiccups, kidney deficiency and dyspnea.

Polygonum cuspidatum: nature and flavor: slightly bitter, slightly cold. Return through: return liver, gallbladder, lung meridian. Efficacy: expelling wind and dampness, dissipating blood stasis and relieving pain, relieving cough and reducing phlegm. Indications: used for arthralgia, damp-heat jaundice, amenorrhea, lumps in the abdomen, water and fire burns, injury from falls, carbuncle sores, cough with excessive phlegm.

Platycodon grandiflorum: nature and flavor: bitter, pungent, flat. Return through: return lung meridian. Efficacy: Nourish the lung, sore throat, eliminate phlegm, drain pus. Indications: used for cough with excess phlegm, chest tightness, sore throat, hoarseness, pulmonary abscess and pus vomiting, sores and ulcers with pus forming but not ulcerating.

Dried Blood: Nature and flavor: sweet, salty, flat. Guixin, Liver Channel. Efficacy: dispelling blood stasis and relieving pain, stopping bleeding and promoting granulation. Indications: used for injuries caused by falls, internal injuries and bruises, and traumatic bleeding.

Donkey-hide gelatin: nature and flavor: sweet, flat. Return through: return lung, liver, kidney channel. Efficacy: Nourishing blood, nourishing yin, moistening dryness and stopping bleeding. Indications: For blood deficiency and chlorosis, dizziness and palpitations, muscle flaccidity and weakness, upset and insomnia, internal movement due to deficiency wind, cough due to dryness of lung, hemoptysis due to labor cough, hematemesis and hematuria, hematochezia and metrorrhagia, fetal leakage during pregnancy.

Polygonatum odoratum: nature and flavor: sweet, slightly cold. Return through: return lung, stomach meridian. Efficacy: nourishing yin and moistening dryness, promoting body fluid and quenching thirst. Indications: For lung and stomach yin injury, dry-heat cough, pharynx and thirst, internal heat and quenching thirst.

American ginseng: sweet in nature, slightly bitter, cool. Guixin, lung, kidney channel. It has the effects of invigorating qi and nourishing yin, clearing away heat and promoting body fluid. For qi deficiency and yin deficiency, internal heat, cough and asthma with phlegm and blood, asthenia heat, dysphoria, thirst, dry mouth and throat. American ginseng has the effects of anti-fatigue, anti-oxidation, anti-stress, inhibition of platelet aggregation, and reduction of blood coagulation. In addition, it also has the effect of regulating blood sugar for diabetic patients.

Radix Astragali: sweet in nature, slightly warm. Return lung, spleen, liver, kidney channel. It has the effects of benefiting qi and solidifying the surface, astringing sweat and solidifying, promoting sores and promoting granulation, diuresis and swelling. It is generally used to treat qi deficiency and fatigue, depression of central qi, chronic diarrhea and prolapse of the anus, bloody stool and metrorrhagia, superficial deficiency and spontaneous sweating, carbuncle and ulceration, chronic ulceration, blood deficiency and chlorosis, internal heat and thirst, chronic nephritis, proteinuria, diabetes, etc.

Saffron: nature and flavor: sweet, flat. Guixin, Liver Channel. Efficacy: promoting blood circulation and removing blood stasis, cooling blood and detoxification, relieving stagnation and calming nerves. Indications: used for amenorrhea lump in the abdomen, postpartum stasis, warm toxin rash, depression, nausea, palpitation and madness.

Salvia miltiorrhiza: bitter in nature and slightly cold in nature. Can promote blood circulation and remove blood stasis, cool blood, soothe the nerves. Enter the heart, spleen two warps. According to "Materia Medica Seeking Truth": Salvia miltiorrhiza has the effect of entering the heart envelope and removing blood stasis. Modern medical research has confirmed that it can dilate coronary arteries, increase coronary flow, improve myocardial ischemia, infarction and heart function, regulate heart rhythm, expand peripheral blood vessels, and improve microcirculation; it can improve the body's ability to withstand hypoxia; it has anticoagulant properties Blood, promote fibrinolysis, inhibit platelet aggregation, and inhibit thrombosis; can reduce blood lipids, inhibit the formation of coronary atherosclerosis; can shorten the recovery period of red blood cells and hemoglobin, increase reticulocytes, and promote tissue repair. Healing of fractures; inhibiting the central nervous system; anti-tumor; enhancing the immune function of the body; lowering blood sugar; inhibiting various bacteria such as Mycobacterium tuberculosis.

Ophiopogon japonicus: Nature and flavor: sweet, slightly bitter, slightly cold. Meridian distribution: Guixin, lung, stomach meridians. Efficacy: Nourishing yin and promoting body fluid, moistening lung and clearing heart. Indications: for dry cough. Asthenic tuberculosis cough, thirsty fluid wound, upset and insomnia, internal heat and thirst, intestinal dryness and constipation; pharyngeal diphtheria.

Gualou (child): cold in nature, sweet in taste, slightly bitter. Return lung, stomach, large intestine channel. Clearing away heat and clearing phlegm, broadening the chest and dispelling stagnation, moistening dryness and smoothing intestines. For lung-heat cough, turbid yellow thick phlegm, chest obstruction and heartache, chest fullness, breast abscess, lung abscess, intestinal abscess swelling and pain, constipation. Modern medical research proves that Trichosanthes can dilate the coronary arteries of the heart and increase coronary flow; it has obvious protective effects on acute myocardial ischemia.

Radix Curcumae: acrid, bitter, cold in nature. Return liver, heart, lung meridian. It is feasible to remove qi and stasis, clear away heart-fire and relieve depression, promote gallbladder and relieve jaundice. It is generally used for amenorrhea dysmenorrhea, chest and abdomen distension, tingling pain, febrile coma, epilepsy, madness, jaundice and red urine.

Dalbergia: pungent in nature, warm. Return liver, spleen channel. It has the effects of promoting qi and blood circulation, relieving pain and stopping bleeding. It is generally used for epigastric and abdominal pain, liver depression and hypochondriac pain, chest pain, tumbling injury, traumatic bleeding.

Barley malt (malt) nature and flavor: sweet, flat. Return through: return spleen, stomach meridian. Efficacy: invigorating the spleen and appetizing, reducing breast milk and reducing swelling. Indications: Used for indigestion, women weaning, burnt malt for digestion and stagnation. For indigestion does not disappear, epigastric distention and pain.

Musk (preferred natural musk): nature and flavor: pungent, warm. Meridian return: GUIXIN, Spleen Channel. Efficacy: Resuscitate and refresh the mind, promote blood circulation and stimulate menstruation, reduce swelling and relieve pain. Indications: used for febrile coma, apoplexy due to phlegm, violent syncope due to stagnation of qi, middle-evil coma, amenorrhea, lumps in the abdomen, dystocia and stillbirth, sudden pain in trusted subordinates, carbuncle and scrofula, sore throat, pain from tumbling, numbness Pain numb.

The traditional Chinese medicine composition provided by the invention has scientific prescriptions, simple preparation methods of various dosage forms, and the obtained products are convenient to take and carry. In addition, the excellent effect of the present invention is also manifested in:

1. The selected materials are all traditional Chinese medicine materials without any toxic and side effects;

2. This prescription is completely in line with the principles of traditional Chinese medicine and the physical and mental characteristics of heart disease patients. Under the premise of the general principle, different prescriptions can be formulated according to different groups of people, with different functions.

3. The source of medicine is easy to obtain, and the cost of medicinal materials is low, which can reduce the burden on patients.

Detailed ways

The technical solutions of the present invention will be described in detail below in conjunction with the examples and experimental examples, but the scope of protection is not limited thereto.

Embodiment 1 The traditional Chinese medicine composition for treating coronary heart disease is prepared from the following raw materials: Curcuma 6g, Barley Malt 20g, Dalbergia 2g, Radix Ophiopogon japonicus 6g, Mother of Pearl 12g, Agarwood 2g, Polygonum cuspidatum 9g, Platycodon grandiflorum 3g, Dried rhizome 2g, donkey-hide gelatin 6g, polygonatum 5g, American ginseng 2g, astragalus 20g, saffron 2g, salvia miltiorrhiza 20g, melon 20g, musk 0.03g.

The preparation method of the above-mentioned Chinese medicine composition water for the treatment of coronary heart disease:

(1) Grind turmeric, barley malt, balsamic, Ophiopogon japonicus, mother-of-pearl, agarwood, knotweed, platycodon grandiflorum, dried blood, donkey-hide gelatin, Polygonatum odoratum, American ginseng, astragalus, saffron, salvia miltiorrhiza and Trichosanthes, and pass through 140 mesh Sieve to get fine powder;

(2) Mix the fine powder obtained in step (1) evenly, place it in a transparent bag, and soak it in cold boiled water with a temperature of 40° C. for 8 hours, and the water consumption is 4 times the weight of the fine powder;

(3) Heat to boiling, take out the permeable bag after 1.2 hours, and concentrate the obtained liquid to 1/2-1/3 of the original volume to obtain a concentrated solution;

(4) Grinding the musk, adding it to the concentrated solution obtained in step (3), and aseptically encapsulating it to obtain the Chinese medicine composition water.

The taking method of the water preparation of the present invention: the water preparation is a course of treatment in 7 days, and takes twice (warming) every day, each 350ml-500ml.

Example 2 The traditional Chinese medicine composition for the treatment of coronary heart disease, prepared from the following raw materials: Curcuma 15g, barley malt 45g, Jiangxiang 6g, Radix Ophiopogon japonicus 15g, mother-of-pearl 18g, agarwood 8g, Polygonum cuspidatum 25g, Bellflower 9g, dried blood 6g, donkey-hide gelatin 12g, polygonatum 12g, American ginseng 6g, astragalus 45g, saffron 6g, salvia miltiorrhiza 45g, trichosanthes 45g, musk 0.1g.

The preparation method of the traditional Chinese medicine composition powder for treating coronary heart disease is as follows: crush each raw material through a 100-mesh sieve to obtain the traditional Chinese medicine composition powder, and divide the powder into 0.4g/bag. Use 2-3 times a day, take one bag each time, mix it with warm water, and take it for 7 days as a course of treatment.

Typical case: xxx, age: 46 years old; gender: female; chief complaint: intermittent chest pain for 3 months; history of present illness: the patient had chest pain with no obvious cause 6 hours ago, which was persistent pain behind the sternum, accompanied by radiation to the back , no abdominal distension, no abdominal pain, no nausea and vomiting, no chills and fever, no cough and expectoration. Discussion: The electrocardiogram showed that the coronary blood supply was obviously insufficient. After examination, chest pain caused by other causes was basically ruled out, and the diagnosis of chest pain caused by coronary heart disease was clear.

Take the Chinese medicine composition powder obtained in this embodiment for treating coronary heart disease, one bag each time, 2 times a day, take it with warm boiled water, a course of treatment for 7 days. Taking it for 21 days, the chest pain is obviously relieved, the disturbance in the heart is also relieved, the appetite is increased, and the spirit can be improved. After taking it for 1 month, the symptoms are eliminated, the night sleep is peaceful, the upset is eliminated, the strength is increased, and the appetite can be improved. After taking it for 2 months, the patient takes it There was no discomfort at the time, and the patient felt healed.

Example 3 The traditional Chinese medicine composition for the treatment of coronary heart disease, prepared from the following raw materials: Curcuma 9g, barley malt 25g, Jiangxiang 3g, Radix Ophiopogon japonicus 9g, mother-of-pearl 14g, agarwood 3g, Polygonum cuspidatum 12g, Bellflower 4g, dried blood 3g, donkey-hide gelatin 8g, polygonatum 6g, American ginseng 3g, astragalus 25g, saffron 3g, salvia miltiorrhiza 25g, melon 25g, musk 0.05g.

The preparation method of the traditional Chinese medicine composition tablet for the treatment of coronary heart disease is: pulverize each crude drug through a 60-mesh sieve to obtain the traditional Chinese medicine composition powder, measure the gained Chinese medicine composition powder according to 0.25g/tablet, and follow the processing and preparation method of the tablet Compressed into round or other tablet dosage forms. Tablets are used twice a day, 2-4 tablets each time, mixed with warm water, a course of treatment is 7 days.

Typical case: xxx, male, 56 years old. Dull pain in the precordial area for more than 2 years, with 2-5 episodes of pain every day, only containing nitroglycerin can relieve it. Symptoms include chest tightness, fear of cold, palpitations, lack of warmth in the limbs, fatigue, swollen legs, backache, chest pain and back pain. ECG showed coronary insufficiency. B-ultrasound showed combined ventricular aneurysm. The pulse is deep and slow, and the fur is thin and white.

Take the Chinese medicine composition tablet obtained in this embodiment for the treatment of coronary heart disease, twice a day, 4 tablets each time, mix it with warm boiled water, and take a course of treatment for 7 days. After taking it for 21 days, the pain in the precordial area was significantly relieved, fatigue and weakness were also relieved, the appetite was increased, and the energy was restored. After taking it for 1 month, the electrocardiogram showed that the coronary blood supply was significantly improved. After taking it for 4 months, the patient recovered.

Example 4 The traditional Chinese medicine composition for the treatment of coronary heart disease, prepared from the following raw materials: Curcuma 12g, barley malt 40g, Jiangxiang 5g, Radix Ophiopogon japonicus 12g, mother of pearl 16g, agarwood 6g, Polygonum cuspidatum 20g, bellflower 6g, dried blood 5g, donkey-hide gelatin 10g, polygonatum 10g, American ginseng 5g, astragalus 40g, saffron 5g, salvia miltiorrhiza 40g, melon 40g, musk 0.08g.

The preparation method of the traditional Chinese medicine composition capsule for treating coronary heart disease is as follows: each crude drug is pulverized through an 80-mesh sieve to obtain a traditional Chinese medicine composition powder; Processed into capsule dosage form.

Typical case: xxx, 60 years old, male, had more severe and frequent angina pectoris than before on a certain day, the duration of angina pectoris was longer than before, the cause was not obvious, he took nitroglycerin, but the curative effect was poor, angina pectoris was accompanied by nausea and vomiting , sweating, bradycardia, acute cardiac insufficiency, severe arrhythmia.

Take the traditional Chinese medicine composition capsules obtained in this embodiment for the treatment of coronary heart disease, two times a day, 4 capsules each time, mix it with warm boiled water, and take a course of treatment for 7 days. After taking it for 21 days, the angina pectoris was obviously alleviated, the symptoms of nausea and vomiting disappeared, the appetite increased, and the spirit was restored. After taking it for 1 month, the electrocardiogram showed that the coronary blood supply was significantly improved. After taking it for 3 months, the patient recovered.

Example 5 The traditional Chinese medicine composition for the treatment of coronary heart disease is prepared from the following raw materials: turmeric 10g, barley malt 30g, radix radix 4g, Radix Ophiopogon japonicus 10g, mother-of-pearl 15g, agarwood 4g, Polygonum cuspidatum 16g, Platycodon grandiflorum 5g, dried blood 4g, donkey-hide gelatin 9g, polygonatum 8g, American ginseng 4g, astragalus 35g, saffron 4g, salvia miltiorrhiza 35g, melon 35g, musk 0.06g.

The preparation method of the Chinese medicine composition water preparation for the treatment of coronary heart disease is:

(1) Grind turmeric, barley malt, dalbergia, Ophiopogon japonicus, mother-of-pearl, agarwood, knotweed, bellflower, dried blood, donkey-hide gelatin, polygonatum odoratum, American ginseng, astragalus, saffron, salvia miltiorrhiza and Trichosanthes, and pass through 130 mesh Sieve to get fine powder;

(2) Mix the fine powder obtained in step (1) evenly, place it in a transparent bag, and soak it in cold boiled water with a temperature of 30° C. for 7 hours, and the water consumption is 3.5 times the weight of the fine powder;

(3) Heat to boiling, take out the permeable bag after 1.0 hour, and concentrate the obtained liquid to 1/2-1/3 of the original volume to obtain a concentrated solution;

(4) Grinding the musk, adding it to the concentrated solution obtained in step (3), and aseptically encapsulating it to obtain the Chinese medicine composition water.

Clinical application of the Chinese medicine composition water preparation for the treatment of coronary heart disease obtained in Example 1 of Test Example 5: From June 2008 to December 2011, 120 patients were screened in 4 hospitals, including 58 females, 62 males, and the oldest 72 years old, the youngest age is 38 years old, and the average age is 55.2 years old. 2 weeks before the test, the crowd was continuously observed, and symptoms and changes were recorded, and they were randomly divided into two groups, an experimental group and a matched group. The experimental group took the product obtained in Example 5, and the matched group took other medicines (metoprolol, lidocaine, etc.) Caine, norepinephrine and other conventional drugs). The method of use is: take twice a day (warm), 350ml-500ml each time (adjusted according to the specific situation), a course of treatment for 7 days. Criteria for judging the curative effect: Cured: After taking this product for a course of treatment, the electrocardiogram shows that the coronary artery blood supply is significantly improved, the discomfort symptoms disappear, and the energy and physical strength are obviously enhanced; effective: after taking this product for a course of treatment, the electrocardiogram shows that the chronic coronary artery blood supply is improved, and the discomfort symptoms are relieved Or part of it disappeared, and the energy and physical strength increased; invalid: after taking this product for a course of treatment, the discomfort symptoms did not change. The results are shown in Table 1.

Table 1: Treatment results for patients with coronary heart disease aged 38-72 years after taking the product of Example 5

Therapeutic effect: 72 cases (72%) were cured, 27 cases (27%) were effective, 1 case (1%) was ineffective, and the total effective rate was 99%. The effect was significantly better than that of the control group.

The self-perceived symptoms and physical and mental changes during the period of taking are shown in Table 2.

Table 2:

The present invention selects American ginseng, trichosanthes, turmeric, barley malt, and balsamic for compatibility, so that these medicines can produce synergistic effect after being combined, and can treat coronary heart disease more effectively. In the prescription, salvia miltiorrhiza, turmeric, jiangxiang, and saffron are mainly used to promote blood circulation, remove blood stasis, dredge collaterals and relieve pain; . Mother-of-pearl, agarwood, knotweed, platycodon grandiflorum, dried blood, and polygonatum are used for distension and pain in the chest and abdomen, dispelling wind and dampness, dispelling blood stasis and relieving pain, nourishing yin and moistening dryness; donkey-hide gelatin enriches blood and nourishes yin. The combination of various medicines can promote blood circulation and nourish yin, dispel blood stasis without hurting the body, open up the mind and replenish qi, so a good therapeutic effect can be obtained. After taking it for 10 days, more than 53% of them felt better, and their discomfort symptoms improved; after taking it for 20 days, more than 72% of them felt better, their discomfort symptoms improved or disappeared, and their spirit and physical strength were enhanced; after taking it for 30 days, more than 97% of them felt better. Some improvement, discomfort symptoms improved or disappeared, mental and physical strength increased, electrocardiogram showed that the coronary blood supply was significantly improved, and some patients felt cured. The effective rate can reach 93% in the experimental group after taking it for more than 30 days, while that in the control group is only 76%.

The prescription of this application is a famous old traditional Chinese medicine prescription, and has passed the demonstration of experts and scholars of Liaocheng University and Liaocheng Hospital of Traditional Chinese Medicine, and has the prospect of industrialization implementation. The inventor of this application is an employee of Shandong University of Political Science and Law (teaching invention and creation). The completion of this invention has benefited from the support of the key discipline of the 12th Five-Year Plan of Shandong Province—the discipline of economic law.

It should be noted that the specific implementation is only a representative example of the present invention, and obviously the technical solution of the present invention is not limited to the above-mentioned embodiments, and many variations are possible. Those of ordinary skill in the art, based on the disclosure of the present invention or obtained without objection from the written description of the document, should be considered as the protection scope of this patent.

Claims (9)

1. the Chinese medicine composition of treatment coronary heart disease is characterized in that, is prepared from following bulk drugs, is weight portion: Radix Curcumae 6-15, Fructus Hordei Germinatus 20-45; Lignum Dalbergiae Odoriferae 2-6, Radix Ophiopogonis 6-15, Concha Margaritifera 12-18, Lignum Aquilariae Resinatum 2-8, Rhizoma Polygoni Cuspidati 9-25; Radix Platycodonis 3-9, Sanguis Draxonis 2-6, Colla Corii Asini 6-12, Rhizoma Polygonati Odorati 5-12, Radix Panacis Quinquefolii 2-6; Radix Astragali 20-45, Stigma Croci 2-6, Radix Salviae Miltiorrhizae 20-45, Fructus Trichosanthis 20-45, Moschus 0.03-0.1.

2. Chinese medicine composition as claimed in claim 1 is characterized in that, Radix Curcumae 9-12, Fructus Hordei Germinatus 25-40, Lignum Dalbergiae Odoriferae 3-5; Radix Ophiopogonis 9-12, Concha Margaritifera 14-16, Lignum Aquilariae Resinatum 3-6, Rhizoma Polygoni Cuspidati 12-20, Radix Platycodonis 4-6; Sanguis Draxonis 3-5, Colla Corii Asini 8-10, Rhizoma Polygonati Odorati 6-10, Radix Panacis Quinquefolii 3-5, Radix Astragali 25-40; Stigma Croci 3-5, Radix Salviae Miltiorrhizae 25-40, Fructus Trichosanthis 25-40, Moschus 0.05-0.08.

3. Chinese medicine composition as claimed in claim 1 is characterized in that, Radix Curcumae 10, Fructus Hordei Germinatus 30, Lignum Dalbergiae Odoriferae 4, Radix Ophiopogonis 10, Concha Margaritifera 15; Lignum Aquilariae Resinatum 4, Rhizoma Polygoni Cuspidati 16, Radix Platycodonis 5, Sanguis Draxonis 4, Colla Corii Asini 9, Rhizoma Polygonati Odorati 8; Radix Panacis Quinquefolii 4, the Radix Astragali 35, Stigma Croci 4, Radix Salviae Miltiorrhizae 35, Fructus Trichosanthis 35, Moschus 0.06.

4. like the arbitrary described Chinese medicine composition of claim 1-3, it is characterized in that, this Chinese medicine composition is processed pharmaceutically acceptable water preparation, powder, tablet or capsule.

5. Chinese medicine composition as claimed in claim 4 is characterized in that, the method for preparing of said water preparation is:

(1) Radix Curcumae, Fructus Hordei Germinatus, Lignum Dalbergiae Odoriferae, Radix Ophiopogonis, Concha Margaritifera, Lignum Aquilariae Resinatum, Rhizoma Polygoni Cuspidati, Radix Platycodonis, Sanguis Draxonis, Colla Corii Asini, Rhizoma Polygonati Odorati, Radix Panacis Quinquefolii, the Radix Astragali, Stigma Croci, Radix Salviae Miltiorrhizae and Fructus Trichosanthis are pulverized, crossed 120-140 mesh sieve (preferred 130 mesh sieves), get fine powder;

(2) with step (1) gained fine powder mix homogeneously, place in the penetrating bag, use cold water immersion 6-8 hour (preferred 7 hour) of temperature as 20-40 ℃ (preferred 30 ℃), water consumption is 3-4 times (preferred 3.5 times) of said fine powder weight;

(3) be heated to boiling, penetrating bag was taken out in (preferred 0.8-1.0 hour) back in lasting 0.6-1.2 hour, and gained liquid gets concentrated solution through being concentrated into the 1/2-1/3 of original volume;

(4) with adding in the concentrated solution of step (3) gained after the Moschus grinding, sterile packaged promptly gets the Chinese medicine composition water preparation.

6. Chinese medicine composition as claimed in claim 4 is characterized in that, the method for preparing of said powder is: each crude drug was pulverized 60-100 mesh sieve (preferred 80-85 mesh sieve), get the Chinese medicine composition medicinal powder.

7. Chinese medicine composition as claimed in claim 4; It is characterized in that; The method for preparing of said tablet is: claim 6 gained Chinese medicine composition medicinal powder according to 0.2-0.3g/ sheet (preferred 0.25g/ sheet) metering, is pressed into circular or other forms of lamellar dosage form according to the preparation for processing of tablet.

8. Chinese medicine composition as claimed in claim 4; It is characterized in that; The method for preparing of said tablet is: claim 6 gained Chinese medicine composition medicinal powder according to 0.2-0.3g/ grain (preferred 0.25g/ grain) metering, is processed into the capsule shape dosage form according to the preparation for processing of capsule.

9. like the application of the arbitrary described Chinese medicine composition of claim 1-3 when coronary heart disease, myocardial necrosis, anginal medicine are treated in preparation.