CN102614459B - Traditional Chinese medicine spray for rapidly curing myocardial ischemia and preparation method thereof - Google Patents
Traditional Chinese medicine spray for rapidly curing myocardial ischemia and preparation method thereof Download PDFInfo
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Abstract
The invention provides a preparation method of a traditional Chinese medicine spray for rapidly curing myocardial ischemia. The preparation method comprises the steps of (1) preparing traditional Chinese medicine extracting solution; (2) preparing an officinal additive; and (3) preparing the spray. The good effects of the traditional Chinese medicine spray are shown as follows: the selected materials are all traditional Chinese medicine materials and do not have any toxic and side effects; and the formula completely conforms to the traditional Chinese medicine principle and the characteristics of mind and body of a cardiopath, and under the premise of the total principle, different formulas are formed according to different crowds, and the functions are different. According to the composition, the burden of a patient can be alleviated as the medicine resources are obtained easily, and the medicines are low in cost. The traditional Chinese medicine spray is quick in curative effect, and is particularly suitable for acute attack of stenocardia and myocardial ischemia.
Description
Technical field
The present invention relates to the Chinese medicine field, particularly relate to medicinal herb spray of a kind of quick treatment myocardial ischemia and preparation method thereof.
Background technology
Myocardial ischemia is meant that the hemoperfusion of heart reduces, and causes the oxygen supply of heart to reduce, and energy metabolism of myocardial is undesired, can not support a kind of pathological state of heart operate as normal.Coronary stenosis that coronary atherosclerosis causes or obturation are to cause main, the modal cause of disease of myocardial ischemia, and then cause myocardial ischemia-anoxemia, " coronary heart disease " that the promptly big daily life of a family of the heart disease that causes is thus said is so coronary heart disease is myocardial ischemia " arch-criminal ".The health of myocardial ischemia serious harm middle-aged and elderly people, in recent years along with growth in the living standard, coronary atherosclerosis presents the trend of rejuvenation, and the performance of myocardial ischemia also appears in the youngster in some 20-30 years.Because myocardial ischemia has the danger that myocardial infarction and sudden death take place, when therefore finding myocardial ischemia, reach early treatment.The atherosclerotic generation of active prevention as taking place, is answered active treatment, prevents and treats pathological development and strives for reverse.Complication person has been taken place, should in time treat, control worsens, and prolongs patient's life-span.
The therapeutic scheme of myocardial ischemia mainly contains: A. antiplatelet drug (as aspirin, clopidogrel) is prevented and treated thrombosis, prevention coronary artery and cerebral artery thrombosis thromboembolism; B. receptor blocking agent (as metoprolol or its slow releasing tablet), decreased heart rate reduces myocardium De Mao oxygen, the prevention sudden death; C. calcium ion antagonist; D. statins (as atorvastatin, Rosuvastatin etc.) reduces the cholesterol in the blood plasma, stablizes artery plaque, prevents the speckle formation thrombosis that comes off; E.RAS system blocking agent (as benazepril and valsartan etc.) prevention remodeling ventricle improves cardiac function etc.; N nitric acid lipid drug (as the different Pyrusussuriensis fat of single nitric acid): coronary artery dilator increases blood supply of cardiac muscle; T. thrombolytic drug dissolves the thrombosis of acute formation, is used for acute myocardial infarction.Seriously then interventional therapy or operative treatment.
Compare with western medicine and medical practitioners, by Chinese traditional treatment, toxic and side effects is lighter, is more vulnerable to numerous medical personnels and friend's patient favor.The Chinese patent literature of application publication number CN 102145044A (application number 201110096779.8) provides a kind of compound spray for the treatment of cardiovascular and cerebrovascular disease, it is that alcoholic solution by crude drug is aided with the pharmaceutic adjuvant wiring solution-forming and makes, described crude drug is made up of Radix Salviae Miltiorrhizae extract and the 32-75% Radix Notoginseng total arasaponins of 25%-68%, by weight percentage: described pharmaceutic adjuvant contains solubilizing agent and propellant, wherein solubilizing agent accounts for the 1-100% of total solution weight, and described solubilizing agent is poly-Pyrusussuriensis vinegar class, the smooth class of fatty acid Pyrusussuriensis, the cruel class of polyoxyethylene fatty acid, the polyoxyethylene aliphatic alcohol ether class, one or more of polyoxyethylene one polyoxypropylene copolymer.The Chinese patent literature of publication number CN 1353981A (application number 01130411.1) relates to a kind of quick-acting aerosol for resisting angina cordis and preparation method thereof, be that propellant is turned to HFC from CFCs, when promptly eliminating, a kind of quick-acting anti-heart stricture of vagina pain aerosols and preparation method thereof are proposed to earth depletion of the ozone layer probability.Publication number CN 1276207A (application number 99107980.9) discloses a kind of preparation method that is used for the treatment of coronary heart disease, anginal medicinal herbs aerosol inhalation agent.This aerosol adopts to be made mixed solvent with Styrax, Borneolum Syntheticum with ethanol and glycerol and dissolves, and is sub-packed in the new technology in the aerosol pressure bottle and makes.The Chinese patent literature of application publication number CN 102370673A (application number 201010259735.8) provides a kind of Chinese medicine compound new drug Su Bing (fast-acting heart disease curing) spray and preparation method thereof, has the anginal good therapeutical effect of resisting coronary heart disease.Prescription is by Styrax, Borneolum Syntheticum, solubilizing agent, absorption enhancer, solvent composition, with almost completely water-fast Borneolum Syntheticum and not with the Storax oil of water immiscible phase by a dissolving, a breast simple new technology such as even with its be dissolved in jointly can be oral water-soluble base in, the oral administration solution that makes is transparent and homogeneous solution, the not stratified suspension that also do not present.
Though the medicine that provides in the prior art more or less all has some curative effects on treatment angina pectoris, myocardial ischemia, the part prescription brings certain toxic and side effects more or less can for patient's gastrointestinal, Liver and kidney.And the part medicine exists takes defectives such as inconvenience, onset is slow.
Summary of the invention
At the deficiencies in the prior art, the purpose of this invention is to provide and a kind ofly prepare simple, taking convenience, be easy to carry, easy medicinal herb spray of the quick treatment myocardial ischemia of clothes and preparation method thereof for a long time.This Chinese medicine composition determined curative effect and having no side effect.Than other preparations absorb fast, rapid-action, can bring into play curative effect faster and better, medication when being suitable for angina pectoris, myocardial ischemia patient acute attack, onset time shortens to 60 seconds greatly with interior (facts have proved that the patient takes 10s with the interior produce effects that gets final product), to present China heart disease take place frequently and rate occurred frequently a good therapeutic new drug is provided.
Technical scheme of the present invention is: treat the preparation method of the medicinal herb spray of myocardial ischemia fast, comprise step:
(1) preparation Chinese medicine extraction liquid: take off and state raw material and add water 1500-2200 part (preferred 1800-2000 part), decocts 20-45 minute (preferred 25-40 minute), filtrate is concentrated, is weight portion: Radix Curcumae 6-15, Fructus Hordei Germinatus 20-45, Lignum Dalbergiae Odoriferae 2-6, Radix Ophiopogonis 6-15, Concha Margaritifera 12-18, Lignum Aquilariae Resinatum 2-8, Rhizoma Polygoni Cuspidati 9-25, Radix Platycodonis 3-9, Sanguis Draxonis 2-6, Colla Corii Asini 6-12, Rhizoma Polygonati Odorati 5-12, Radix Panacis Quinquefolii 2-6, Radix Astragali 20-45, Stigma Croci 2-6, Radix Salviae Miltiorrhizae 20-45, Fructus Trichosanthis 20-45;
(2) preparation medical additive: take off and state raw material and mix and grind and be fine powder, be weight portion: Moschus 0.02-0.08, Borneolum Syntheticum 0.05-0.3;
(3) preparation spray: medical additive is placed the Chinese medicine extraction liquid mix homogeneously, and the consumption of medical additive is the 0.5-3% of Chinese medicine extraction liquid weight, is aided with pharmaceutically acceptable carrier (or adjuvant) and packs and get.
Described preparation method, preferred scheme is each raw material in the step (1): Radix Curcumae 9-12, Fructus Hordei Germinatus 25-40, Lignum Dalbergiae Odoriferae 3-5, Radix Ophiopogonis 9-12, Concha Margaritifera 14-16, Lignum Aquilariae Resinatum 3-6, Rhizoma Polygoni Cuspidati 12-20, Radix Platycodonis 4-6, Sanguis Draxonis 3-5, Colla Corii Asini 8-10, Rhizoma Polygonati Odorati 6-10, Radix Panacis Quinquefolii 3-5, Radix Astragali 25-40, Stigma Croci 3-5, Radix Salviae Miltiorrhizae 25-40, Fructus Trichosanthis 25-40.Be more preferably each raw material in the step (1): Radix Curcumae 10, Fructus Hordei Germinatus 30, Lignum Dalbergiae Odoriferae 4, Radix Ophiopogonis 10, Concha Margaritifera 15, Lignum Aquilariae Resinatum 4, Rhizoma Polygoni Cuspidati 16, Radix Platycodonis 5, Sanguis Draxonis 4, Colla Corii Asini 9, Rhizoma Polygonati Odorati 8, Radix Panacis Quinquefolii 4, the Radix Astragali 35, Stigma Croci 4, Radix Salviae Miltiorrhizae 35, Fructus Trichosanthis 35.
Described preparation method, preferred scheme is each raw material in the step (2): Moschus 0.04-0.06, Borneolum Syntheticum 0.1-0.2.Be more preferably Moschus 0.05, Borneolum Syntheticum 0.15.
Described preparation method, preferred scheme are that the consumption of medicinal additive is the 1-2% (preferred 1.2-1.8%) of Chinese medicine extraction liquid weight in the step (3).Be more preferably, the consumption of medical additive is 1.5% of a Chinese medicine extraction liquid weight.
The pharmacology of the used main raw material of Chinese medicine of the present invention is as follows:
Concha Margaritifera: nature and flavor: salty, cold.Gui Jing: return liver, heart channel.Effect: suppressing the hyperactive liver and subsiding YANG, arresting convulsion makes eye bright.Cure mainly: it is dizzy to be used to have a headache. irritated insomnia, liver-heat conjunctival congestion, deficiency of the liver blurred vision." Chinese medicine voluminous dictionary ": this thing (Concha Margaritifera) is double goes into the heart, liver two warps, with Concha Haliotidis but go into the Liver Channel person is different, so relate to the mind patient, must this.
Lignum Aquilariae Resinatum: nature and flavor: hot, bitter, tepor.Gui Jing: return spleen, stomach, kidney channel.Effect: promoting the circulation of QI to relieve pain, warming middle-JIAO to arrest vomiting, helping inspiration to relieve asthma.Cure mainly: be used for the vexed pain of breast abdominal distention, gastrofrigid vomiting singultus, the QI rising in reverse order of suffering from a deficiency of the kidney dyspnea with rapid respiration.
Rhizoma Polygoni Cuspidati: nature and flavor: little hardship is slightly cold.Gui Jing: return liver, gallbladder, lung meridian.Effect: expelling wind and removing dampness, dissipating blood stasis analgesic therapy, relieving cough and resolving phlegm.Cure mainly: be used for arthralgia, jaundice due to damp-heat, amenorrhea ， mass in the abdomen, burn due to hot liquid or fire, injury from falling down, carbuncle sore tumefacting virus, cough with copious phlegm.
Radix Ophiopogonis: nature and flavor: sweet, little hardship is slightly cold.Gui Jing: GUIXIN, lung, stomach warp.Effect: YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire.Cure mainly: be used for dryness of the lung dry cough.The chronic consumptive disease cough, Tianjin wound is thirsty, vexed insomnia, interior-heat is quenched one's thirst, the dryness of the intestine constipation; Pharyngeal diphtheria.
Radix Platycodonis: nature and flavor: bitter, hot, flat.Gui Jing: return lung meridian.Effect: lung qi dispersing, sore-throat relieving eliminates the phlegm, evacuation of pus.Cure mainly: be used for cough with copious phlegm, uncomfortable in chest not smooth, pharyngalgia, hoarseness, lung abscess vomiting pus, skin infection difficulty in discharging of pus.
Sanguis Draxonis: nature and flavor: sweet, salty, flat.Gui Jing: GUIXIN, Liver Channel.Effect: removing blood stasis and relieving pain, hemostasia and promoting granulation.Cure mainly: be used to fall pounce on and lose ecchymoma due to internal injury; Continuous bleeding due to traumatic injury.
Colla Corii Asini: nature and flavor: sweet, flat.Gui Jing: return lung, liver, kidney channel.Effect: the YIN nourishing of enriching blood, moisturize hemostasis.Cure mainly: be used for blood deficiency and yellow complexion, dizzy cardiopalmus, the flesh flaccidity is unable, dysphoria and insomnia, stirring-up of pathogenic wind in the interior resulting from deficiency, xeropulmonary cough, chronic cough spitting of blood, haematemesis hematuria, the metrorrhagia of having blood in stool, vaginal bleeding during pregnancy.
Rhizoma Polygonati Odorati: nature and flavor: sweet, be slightly cold.Gui Jing: attach to the lung and stomach meridians.Effect: nourishing YIN to relieve dryness, promoting the production of body fluid to quench thirst.Cure mainly: be used for the lung stomach-Yin and hinder, cough caused by dryness-heat is swallowed in thirsty, and interior-heat is quenched one's thirst.
Radix Panacis Quinquefolii: sweet, the little hardship of property, cold.GUIXIN, lung, kidney channel.Effect with boosting qi and nourishing yin, clearing away heat and promoting production of body fluid.It is thanks to cloudy to be used for the deficiency of vital energy, interior-heat, and cough with asthma expectorant blood, deficiency-heat is tired tired, quenches one's thirst dryness of the mouth and throat.Radix Panacis Quinquefolii has the effect of resisting fatigue, antioxidation, anti-stress, anticoagulant, reduction blood coagulation, in addition, diabetics is also had the effect of blood sugar regulation.
The Radix Astragali: property is sweet, tepor.Return lung, spleen, liver, kidney channel.There are benefiting QI for strengthening the superficies, arresting sweating to take off, hold in the palm the effect of skin ulcer granulation promoting, inducing diuresis to remove edema admittedly.It is weak generally to be used for the treatment of the deficiency of vital energy, sinking of QI of middle-JIAO, and the chronic diarrhea proctoptosis, the metrorrhagia of having blood in stool, the exterior deficiency spontaneous perspiration, carbuncle is difficult bursts, and burst for a long time and do not hold back, blood deficiency and yellow complexion, interior-heat is quenched one's thirst, chronic nephritis, albuminuria, diabetes etc.
Stigma Croci: nature and flavor: sweet, flat.Gui Jing: GUIXIN, Liver Channel.Effect: blood circulation promoting and blood stasis dispelling, removing pathogenic heat from blood and toxic substance from the body, resolving stagnation for tranquilization.Cure mainly: be used for amenorrhea and mass in the abdomen, postpartum stagnation, maculae caused by violent heat pathogen, melancholy painful abdominal mass is vexed, and palpitation with fear is gone mad.
Radix Salviae Miltiorrhizae: nature and flavor hardship, cold nature.The energy blood circulation promoting and blood stasis dispelling, removing heat from blood is calmed the nerves.Go into the heart, spleen two warps.According to " book on Chinese herbal medicine is looked for the truth ": Radix Salviae Miltiorrhizae has the effect into the percardium removing blood stasis with potent drugs.Modern medicine study confirms that its energy coronary artery dilator increases coronary flow, improves myocardial ischemia, infraction and cardiac function, regulates the rhythm of the heart, and can expand peripheral blood vessel, microcirculation improvement; Can improve body's hypoxia tolerance; Anticoagulation is arranged, promote fibrinolytic, suppress platelet aggregation, suppress thrombotic effect; The energy blood fat reducing suppresses coronary atherosclerosis and forms; Can shorten the convalescent period of erythrocyte and hematochrome, Reticulocyte is increased, can promote the reparation of tissue, quicken the healing of fracture; There is nervus centralis that inhibitory action is arranged; Antitumor action is arranged; Energy enhancing human body immunity function; The energy blood sugar lowering; Various bacteria such as tubercule bacillus there is inhibitory action.
Fructus Trichosanthis (son): cold in nature, sweet in the mouth, little hardship.Return lung, stomach, large intestine channel.Clearing away heat and eliminating phlegm, relieving stuffiness of the chest by dispersing aggregation of pathogens is moisturized laxation.Be used for the cough due to lung-heat, the turbid Huang of expectorant is thick, obstruction of qi in the chest and cardialgia, and the blocked-up chest feeling of fullness, acute mastitis, lung abscess, acute appendicitis swells and ache, constipation.Modern medicine and pharmacology studies have shown that: Fructus Trichosanthis has expansion heart arteria coronaria, increases the coronary flow effect; Acute myocardial ischemia there is significant protective effect.
Radix Curcumae: property suffering, hardship, cold.Return liver, the heart, lung meridian.But regulating qi to disperse stagnation, heart fire-clearing upset-relieving, promoting the function of the gallbladder to alleviate jaundice.Generally be used for the amenorrhea dysmenorrhea, chest and abdomen swelling and pain, twinge, the calentura coma, epilepsy is gone mad, the jaundice dark coloured urine.
Lignum Dalbergiae Odoriferae: property suffering, temperature.Return liver, spleen channel.Has promoting flow of QI and blood, pain relieving, hemostasia effect.Generally be used for epigastric pain, hypochondriac pain due to stagnation of liverQI, thoracic obstruction twinge, injury from falling down, traumatic hemorrhage.
Fructus Hordei Germinatus nature and flavor: sweet, flat.Gui Jing: return spleen, stomach warp.Effect: spleen benefiting and stimulating the appetite, move back newborn relieving distension.Cure mainly: be used for food stagnation and do not disappear, women's ablactation, Fructus Hordei Germinatus (parched to brown) relieving dyspepsia.Be used for food stagnation and do not disappear, abdominal distention.
Moschus (natural): nature and flavor: suffering, temperature.Gui Jing: GUIXIN, spleen channel.Effect: the refreshment of having one's ideas straightened out, promoting blood circulation to restore menstrual flow, reducing swelling and alleviating pain.Cure mainly: be used for the calentura coma, the apoplexy syncope due to accumulation of phlegm, stagnation of QI sudden syncope, the attacked by pestiferous factors stupor, amenorrhea ， mass in the abdomen, the difficult labour stillborn fetus, trusted subordinate's sudden pain, the carbuncle scrofula, laryngopharynx swelling and pain falls and pounces on the pain of injury, the arthralgia pain numbness.
Borneolum Syntheticum (natural Broneolum Syntheticum): property is arduous, cold.Can " treat sore throat, headache, breath, toothache, the typhoid fever protrusion of the tongue, children's's pox falls into.Logical all keys, the stagnated fire of loosing." (" detailed outline ").
Spray prescription science provided by the invention, the preparation method of dosage form can be with reference to existing document, the products obtained therefrom taking convenience, is easy to carry.In addition, excellent results of the present invention also shows:
1, selected materials is all the Chinese medicine material, and is without any side effects;
2, this prescription meets Chinese medicine principle and cardiac's body and mind characteristics fully, under the prerequisite of general principle, can different prescriptions be arranged according to different crowd, the function difference.
3, the medicine source is easy to get, and medical material is with low cost, can relieve patient ' s burden.
4, curative effect is rapid, is particularly suitable for the acute attack of angina pectoris, myocardial ischemia.
The specific embodiment
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
Embodiment 1 is the preparation method of the medicinal herb spray of treatment myocardial ischemia fast, comprises step:
(1) preparation Chinese medicine extraction liquid: take off and state raw material and add 2200 parts in water, decocted 45 minutes, filtrate is concentrated, is weight portion (every part of 20g): Radix Curcumae 15, Fructus Hordei Germinatus 45, Lignum Dalbergiae Odoriferae 6, Radix Ophiopogonis 15, Concha Margaritifera 18, Lignum Aquilariae Resinatum 8, Rhizoma Polygoni Cuspidati 25, Radix Platycodonis 9, Sanguis Draxonis 6, Colla Corii Asini 12, Rhizoma Polygonati Odorati 12, Radix Panacis Quinquefolii 6, the Radix Astragali 45, Stigma Croci 6, Radix Salviae Miltiorrhizae 45, Fructus Trichosanthis-45;
(2) preparation medical additive: take off and state raw material and mix and grind and be fine powder, be weight portion (every part of 20g): Moschus 0.08, Borneolum Syntheticum 0.3;
(3) preparation spray: medical additive is placed the Chinese medicine extraction liquid mix homogeneously, the consumption of medical additive is 3% of a Chinese medicine extraction liquid weight, being aided with pharmaceutically acceptable carrier (all can obtain from prior art such as solubilizing agent, deodorizer, lytic agent, propellant etc., used packing also can be selected suitable material for use) packs and gets.
Instructions of taking of the present invention: suffer from angina pectoris or chest pain medical history person, every day, intermittence was taken, and sprayed into the oral cavity when taking, and contained 5-10 after second, swallowed every day 5-12 time, each 5ml-20ml.When angina pectoris, myocardial ischemia acute attack, spray into the oral cavity and swallow, each 5ml-20ml.
Embodiment 2 is the preparation method of the medicinal herb spray of treatment myocardial ischemia fast, comprises step:
(1) preparation Chinese medicine extraction liquid: take off and state raw material and add 1500 parts in water, decocted 20 minutes, filtrate is concentrated, is weight portion (every part of 30g): Radix Curcumae 6, Fructus Hordei Germinatus 20, Lignum Dalbergiae Odoriferae 2, Radix Ophiopogonis 6, Concha Margaritifera 12, Lignum Aquilariae Resinatum 2, Rhizoma Polygoni Cuspidati 9, Radix Platycodonis 3, Sanguis Draxonis 2, Colla Corii Asini 6, Rhizoma Polygonati Odorati 5, Radix Panacis Quinquefolii 2, the Radix Astragali 20, Stigma Croci 2, Radix Salviae Miltiorrhizae 20, Fructus Trichosanthis 20;
(2) preparation medical additive: take off and state raw material and mix and grind and be fine powder, be weight portion (every part of 30g): Moschus 0.02, Borneolum Syntheticum 0.05;
(3) preparation spray: medical additive is placed the Chinese medicine extraction liquid mix homogeneously, and the consumption of medical additive is 0.5% of a Chinese medicine extraction liquid weight, is aided with pharmaceutically acceptable carrier package and gets.
Model case: xxx, the age: 63 years old; Sex: male; The coronary disease medical history is arranged, and no obvious inducement chest pain appearred in the patient before 6 hours, for vexed pain behind the breastbone, be persistence, the radiation of companion's back part, and no abdominal distention does not have stomachache, no nausea and vomiting, no fear of cold heating, no cough and expectoration.Discussion: angina pectoris due to the electrocardio diagram coronary insufficiency, the chest pain that the basic eliminating of process inspection other reasons causes, coronary heart disease, myocardial ischemia diagnosis are clearly.
Take the medicinal herb spray of present embodiment gained treatment myocardial ischemia, 7 days courses of treatment.The patient takes a moment, self-induction remission.After taking 21 days, chest pain obviously alleviates, and confusingly in the heart also alleviates, and the amount of receiving increases, spirit can, took 3 months, symptom is eliminated, the peace of sleeping night, vexed removing, strength increases, receive food can, recovery from illness any discomfort do not appear, in the clothes 8 months of continuing when the patient takes.
Embodiment 3 is the preparation method of the medicinal herb spray of treatment myocardial ischemia fast, comprises step:
(1) preparation Chinese medicine extraction liquid: take off and state raw material and add 1800 parts in water, decocted 25 minutes, filtrate is concentrated, is weight portion (every part of 5g): Radix Curcumae 12, Fructus Hordei Germinatus 40, Lignum Dalbergiae Odoriferae 5, Radix Ophiopogonis 12, Concha Margaritifera 16, Lignum Aquilariae Resinatum 6, Rhizoma Polygoni Cuspidati 20, Radix Platycodonis 6, Sanguis Draxonis 5, Colla Corii Asini 10, Rhizoma Polygonati Odorati 10, Radix Panacis Quinquefolii 5, the Radix Astragali 40, Stigma Croci 5, Radix Salviae Miltiorrhizae 40, Fructus Trichosanthis 40.
(2) preparation medical additive: take off and state raw material and mix and grind and be fine powder, be weight portion (every part of 5g): Moschus 0.06, Borneolum Syntheticum 0.2.
(3) preparation spray: medical additive is placed the Chinese medicine extraction liquid mix homogeneously, and the consumption of medical additive is 1% of a Chinese medicine extraction liquid weight, is aided with pharmaceutically acceptable carrier package and gets.
Model case: xxx, male, 57 years old.Precordialgia 4 years surplus; Several months increase the weight of, and every day, the pain outbreak was 5 times, and containing nitroglycerin could alleviate.Have uncomfortable in chest, be afraid of cold, cardiopalmus, extremities being not warm is warm, fatigue and weak, the lower limb soreness of waist that swells, diseases such as chest pain radiating to the back.Electrocardio diagram coronary insufficiency.Deep-slow pulse, white and thin fur.
Take the medicinal herb spray of present embodiment gained treatment myocardial ischemia, 7 days courses of treatment.The patient takes the back symptom to be alleviated immediately.Took 1 month, precordialgia obviously alleviates, and fatigue and weak also alleviates, and the amount of receiving increases, spirit can, took 3 months, the blood supply of electrocardio diagram coronary artery obviously improves, the clothes 6 months of continuing, patient's recovery from illness.
Embodiment 4 is the preparation method of the medicinal herb spray of treatment myocardial ischemia fast, comprises step:
(1) preparation Chinese medicine extraction liquid: take off and state raw material and add 2000 parts in water, decocted 40 minutes, filtrate is concentrated, is weight portion (every part of 25g): Radix Curcumae 9, Fructus Hordei Germinatus 25, Lignum Dalbergiae Odoriferae 3, Radix Ophiopogonis 9, Concha Margaritifera 14, Lignum Aquilariae Resinatum 3, Rhizoma Polygoni Cuspidati 12, Radix Platycodonis 4, Sanguis Draxonis 3, Colla Corii Asini 8, Rhizoma Polygonati Odorati 6, Radix Panacis Quinquefolii 3, the Radix Astragali 25, Stigma Croci 3, Radix Salviae Miltiorrhizae 25, Fructus Trichosanthis 25.
(2) preparation medical additive: take off and state raw material and mix and grind and be fine powder, be weight portion (every part of 25g): Moschus 0.04, Borneolum Syntheticum 0.1.
(3) preparation spray: medical additive is placed the Chinese medicine extraction liquid mix homogeneously, and the consumption of medical additive is 1.8% of a Chinese medicine extraction liquid weight, is aided with pharmaceutically acceptable carrier package and gets.
Embodiment 5 is the preparation method of the medicinal herb spray of treatment myocardial ischemia fast, comprises step:
(1) preparation Chinese medicine extraction liquid: take off and state raw material and add 2000 parts in water, decocted 30 minutes, filtrate is concentrated, is weight portion (every part of 10g): Radix Curcumae 10, Fructus Hordei Germinatus 30, Lignum Dalbergiae Odoriferae 4, Radix Ophiopogonis 10, Concha Margaritifera 15, Lignum Aquilariae Resinatum 4, Rhizoma Polygoni Cuspidati 16, Radix Platycodonis 5, Sanguis Draxonis 4, Colla Corii Asini 9, Rhizoma Polygonati Odorati 8, Radix Panacis Quinquefolii 4, the Radix Astragali 35, Stigma Croci 4, Radix Salviae Miltiorrhizae 35, Fructus Trichosanthis 35.
(2) preparation medical additive: take off and state raw material and mix and grind and be fine powder, be weight portion (every part of 10g): Moschus 0.05, Borneolum Syntheticum 0.15;
(3) preparation spray: medical additive is placed the Chinese medicine extraction liquid mix homogeneously, and the consumption of medical additive is 1.5% of a Chinese medicine extraction liquid weight, is aided with pharmaceutically acceptable carrier package and gets.
Test example 1 embodiment 5 gained are treated the clinical practice of the medicinal herb spray of myocardial ischemia fast: in May, 2009-2012 year January, screen 120 routine angina pectoriss, myocardial ischemia patient 5 Grade III Class A hospitals, women's 62 examples wherein, male's 58 examples, oldest 77 years old, minimal ages 34 years old, 57.2 years old mean age.In 2 weeks before the test, this crowd is observed continuously record symptom and variation, be divided into two groups at random, experimental group and matched group, experimental group are taken embodiment 5 products obtained therefroms, and matched group is taken other medicine (conventional medicines such as metoprolol, lignocaine, norepinephrine).Curative effect situation criterion: cure: take course of treatment of this product, the blood supply of electrocardio diagram coronary artery obviously improves, and malaise symptoms disappears, and energy and muscle power obviously strengthen; Effectively: take course of treatment of this product, electrocardio illustrates chronic coronary artery blood supply to be improved, and malaise symptoms alleviates or part disappears, and energy and muscle power strengthen; Invalid: as to take course of treatment of this product, malaise symptoms no change.The result is as shown in table 1.
Table 1: take embodiment 5 product 35-75 year myocardial ischemia crowd therapeutic outcome
Therapeutic effect: cure 72 examples (72%), effective 27 examples (27%), invalid 1 example (1%), total effective rate 99%.Effect obviously is better than matched group.
Self-induction symptom and physical change of spirit thereof are as shown in table 2 during taking.
Table 2:
The present invention selects Radix Panacis Quinquefolii, Fructus Trichosanthis, Radix Curcumae, Fructus Hordei Germinatus, Lignum Dalbergiae Odoriferae etc. to carry out compatibility, makes to produce synergism behind these drug regimens, can more effectively treat coronary heart disease.Radix Salviae Miltiorrhizae, Radix Curcumae, Lignum Dalbergiae Odoriferae, Stigma Croci master are at blood circulation promoting and blood stasis dispelling, removing obstruction in the collateral to relieve pain in the side; Radix Panacis Quinquefolii, the Radix Astragali, Radix Ophiopogonis Replenishing QI and nourishing YIN, hold up this training unit; Fructus Trichosanthis a surname numbness the chest stuffiness relieving; Moschus, Borneolum Syntheticum are warded off and are dirtyly had one's ideas straightened out.Concha Margaritifera, Lignum Aquilariae Resinatum, Rhizoma Polygoni Cuspidati, Radix Platycodonis, Sanguis Draxonis, Rhizoma Polygonati Odorati are used for the vexed pain of breast abdominal distention, expelling wind and removing dampness, dissipating blood stasis analgesic therapy, nourishing YIN to relieve dryness; The Colla Corii Asini nourishing blood YIN nourishing.All medicines share, and invigorate blood circulation and can yin nourishing, and blood stasis dispelling and just not hindering is had one's ideas straightened out and the QI invigorating of holding concurrently, so can obtain excellent curative.Take in back ten seconds, feeling more than 50% takes a turn for the better to some extent; Took 20 days, feeling more than 75% takes a turn for the better to some extent, and malaise symptoms improves or disappears, and spirit, muscle power strengthen; Took 30 days, feeling more than 98% takes a turn for the better to some extent, and malaise symptoms improves or disappears, and spirit, muscle power strengthen, and the blood supply of electrocardio diagram coronary artery obviously improves the recovery from illness of part patient's self-induction.Take in the experimental group more than 30 days, effective percentage can reach 93%, and matched group only is 79%.Matched group was taken in back ten seconds, and what self-induction doing well,improving and the blood supply of electrocardio diagram coronary artery improved only accounts for 19%.
The application's prescription is the distinguished veteran doctors of TCM proved recipe, and has passed through Liaocheng University, Liaocheng City hospital of traditional Chinese hospital experts and scholars' demonstration, has industrialization application prospect.The present inventor is the employee of the Shandong institute of political science and law (speaker's innovation and creation), and finishing of this invention has benefited from Shandong Province's 12 planning key discipline---supports of Law of Economy subject fund.
Should be pointed out that the specific embodiment is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to the foregoing description, and a lot of distortion can also be arranged.Those of ordinary skill in the art, with the present invention clear and definite disclosed or according to undoubted the obtaining of the written description of file, all should think the claimed scope of this patent.
Claims (7)
1. treat the preparation method of the medicinal herb spray of myocardial ischemia fast, it is characterized in that, comprise step:
(1) preparation Chinese medicine extraction liquid: take off and state raw material and add water 1500-2200 part, decocted 20-45 minute, filtrate is concentrated, is weight portion: Radix Curcumae 6-15, Fructus Hordei Germinatus 20-45, Lignum Dalbergiae Odoriferae 2-6, Radix Ophiopogonis 6-15, Concha Margaritifera 12-18, Lignum Aquilariae Resinatum 2-8, Rhizoma Polygoni Cuspidati 9-25, Radix Platycodonis 3-9, Sanguis Draxonis 2-6, Colla Corii Asini 6-12, Rhizoma Polygonati Odorati 5-12, Radix Panacis Quinquefolii 2-6, Radix Astragali 20-45, Stigma Croci 2-6, Radix Salviae Miltiorrhizae 20-45, Fructus Trichosanthis 20-45;
(2) preparation medical additive: take off and state raw material and mix and grind and be fine powder, be weight portion: Moschus 0.02-0.08, Borneolum Syntheticum 0.05-0.3;
(3) preparation spray: medical additive is placed the Chinese medicine extraction liquid mix homogeneously, and the consumption of medical additive is the 0.5-3% of Chinese medicine extraction liquid weight, is aided with pharmaceutically acceptable carrier package and gets.
2. preparation method as claimed in claim 1 is characterized in that, each raw material in the step (1): Radix Curcumae 9-12, Fructus Hordei Germinatus 25-40, Lignum Dalbergiae Odoriferae 3-5, Radix Ophiopogonis 9-12, Concha Margaritifera 14-16, Lignum Aquilariae Resinatum 3-6, Rhizoma Polygoni Cuspidati 12-20, Radix Platycodonis 4-6, Sanguis Draxonis 3-5, Colla Corii Asini 8-10, Rhizoma Polygonati Odorati 6-10, Radix Panacis Quinquefolii 3-5, Radix Astragali 25-40, Stigma Croci 3-5, Radix Salviae Miltiorrhizae 25-40, Fructus Trichosanthis 25-40.
3. preparation method as claimed in claim 2 is characterized in that, each raw material in the step (1): Radix Curcumae 10, Fructus Hordei Germinatus 30, Lignum Dalbergiae Odoriferae 4, Radix Ophiopogonis 10, Concha Margaritifera 15, Lignum Aquilariae Resinatum 4, Rhizoma Polygoni Cuspidati 16, Radix Platycodonis 5, Sanguis Draxonis 4, Colla Corii Asini 9, Rhizoma Polygonati Odorati 8, Radix Panacis Quinquefolii 4, the Radix Astragali 35, Stigma Croci 4, Radix Salviae Miltiorrhizae 35, Fructus Trichosanthis 35.
4. preparation method as claimed in claim 1 is characterized in that, each raw material in the step (2): Moschus 0.04-0.06, Borneolum Syntheticum 0.1-0.2.
5. preparation method as claimed in claim 4 is characterized in that, Moschus 0.05, Borneolum Syntheticum 0.15.
6. preparation method as claimed in claim 1 is characterized in that, the consumption of medicinal additive is the 1-2% of Chinese medicine extraction liquid weight in the step (3).
7. preparation method as claimed in claim 6 is characterized in that, the consumption of medical additive is 1.5% of a Chinese medicine extraction liquid weight.
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