CN103285327B - Traditional Chinese medicine composition tablet for treating coronary heart diseases and preparation method thereof - Google Patents
Traditional Chinese medicine composition tablet for treating coronary heart diseases and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition tablet for treating coronary heart diseases. The capsule is prepared from the following active pharmaceutical ingredients in parts by weight: 6-15 parts of turmeric root tuber, 20-45 parts of barley malt, 2-6 parts of rosewood, 6-15 parts of dwarf lilyturf tuber, 12-18 parts of nacre, 2-8 parts of agilawood, 9-25 parts of giant knotweed rhizome, 3-9 parts of platycodon root, 2-6 parts of draconis resin, 6-12 parts of ass hide glue, 5-12 parts of fragrant solomonseal rhizome, 2-6 parts of American ginseng, 20-45 parts of radix astragali, 2-6 parts of saffron, 20-45 parts of salvia miltiorrhiza, 20-45 parts of snake gourd fruit and 0.03-0.1 part of musk. The tablet has the excellent effects that all the selected materials are traditional Chinese medicine materials and do not have any toxic or side effects; the prescription completely conforms to the principles of the traditional Chinese medicines and the physical and mental characteristics of patients with heart diseases; on the premise of general principles, different prescriptions can be provided to different crowds and have different functions; and the medicine sources are easy to obtain, the medicine cost is low, and the burdens of patients can be reduced.
Description
The application is divisional application: original bill application number: 201210091229.1, and the applying date: 2012.3.31, denomination of invention: Chinese medicine composition for the treatment of coronary heart disease and preparation method thereof.
Technical field
The present invention relates to Chinese medicine field, particularly relate to a kind of Chinese medicine composition for the treatment of coronary heart disease and preparation method thereof.
Background technology
Coronary atherosclerotic heart disease (hereinafter to be referred as coronary heart disease) is because selenium shape atherosclerosis causes myocardial ischemia, the caused heart disease of anoxia.And 95% above myocardial infarction is many to be formed by coronary heart disease development, and acute myocardial infarction mortality rate is very high, mostly 30%～40%, is the commonly encountered diseases of serious threat human life, health.
Coronary heart disease generally belongs to the categories such as the traditional Chinese medical science " thoracic obstruction ", " precordial pain with cold limbs ", " angina pectoris ".Just on the books in Huangdi's Internal Classics: " pained person, chest pain, discomfort and fullness in the hypochondrium, pain over the hypochondrium, bears pain between back of the body shoulder blade." and for example " Ling Shu Miraculous Pivot or Divine Axis faint disease " section say: " angina pectoris, bluish colour of the limbs extending up to the elbows and knees, very pained.Onset of disease in the morning and dying in the evening, onset of disease in the evening and dying in the next morning." quite similar angina pectoris and myocardial infarction.Han dynasty Zhang Zhongjing has further been made a series of arteries and veins cards and has been described in chapters such as " Medical Treasures of the Golden Chamber obstruction of qi in the chest and cardialgia lose heart abnormal pulse card control ", and proposes the square medicine of comparison system.As " pain over the chest and back, loses heart for the disease of the thoracic obstruction, dyspnea and expectoration, pulse at CUN KOU being deep and slow, GUAN being pulse faint, tense and rapid, Gualou Xiebai Baijiu Tang "; And for example " unable to tie down due to obstruction of QI in the chest, chest pain radiating to the back person, Gualou Xiebai Banxia Tang master it ".Ancient Chinese medicine doctor to all performances to some extent of dialectical, square medicine, has accumulated a whole set of Chinese medicine and has prevented and treated the clinical experience of coronary heart disease on this basis in long term medical practice.
The research of modern TCM to coronary heart disease, clinical article sees nineteen fifty-five the earliest, proposes primary disease and is equivalent to the traditional Chinese medical science it " thoracic obstruction ", " angina pectoris ".The fifties, Clinical Exploration and basic research were few taking case introduction as main.The sixties, clinical data increased gradually, and etiology and pathogenesis to primary disease, treatment rule, differentiation of symptoms and signs for classification of syndrome, treatment side's medicine etc. are set forth to some extent, and have obtained preliminary curative effect, but basic research is still little; To the seventies clinical data and theoretic discussion showed increased, constantly holding of national academic conference, has promoted research work development, and curative effect is improved constantly.Chinese medicine is not only applied to control angina pectoris, also for rescuing acute myocardial infarction.This Tou has summed up more clinical experience period, and verification is controlled rule and explored.Method for the treatment of has determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, cipher prescription, folk prescription proved recipe, acupuncture, massage etc.The rule for the treatment of has blood circulation promoting and blood stasis dispelling, a surname's numbness, aromatic herbs activating YANG and supplementing QI and nourishing YIN is invigorated blood circulation, benefiting QI for activating blood circulation and righting the kidney invigorating etc. activates yang.Aspect dialectical consistent generally acknowledge mostly belong to syndrome of intermingled deficiency and excess, internal organs virtual loss functional disorder be this, blood stasis, the stagnation of QI, expectorant are turbid, cold coagulation numbness resistance heart arteries and veins is for marking.Form of Chinese drug, is main quick-effective preparation and the expansion blood vessel Chinese medicine that develops into sheet, cream, ball, electuary, aerosol and injection, particularly allevating angina pectoris from decoction, has greatly improved the clinical value for the treatment of coronary disease with traditional Chinese medicine.Acute myocardial infarction is rescued in the combination of Chinese and Western medicine makes the case fatality rate of primary disease be down to 12% left and right from 30%～40%.Basic research aspect, finds that activating blood and removing stasis Method and blood circulation promoting medicine have increase coronary flow, reduces myocardial oxygen consumption, anticoagulant and anticoagulant and thrombolytic, the effect of protection ischemic myocardium.Since the eighties, though the excavation of the new method of new drug is not many, existing side's medicine has further been affirmed to curative effect, further investigation pharmacological action and analysis effective ingredient are done a lot of work.As studied to inquire into the mechanism of action of the blood circulation promoting and blood stasis dispelling rule for the treatment of from aspects such as hemorheology, microcirculation and cardiac inspections, and carry out antiatherogenic research etc.
Publication number CN 1498645A(application number 02148326.4) Chinese patent literature disclose one and be used for the treatment of cerebral infarction sequela and coronary heart disease Chinese medicinal capsule and manufacture method thereof, this Chinese medicinal capsule is by Pheretima 15-20 gram, eupolyphage sece steleophaga 15-20 gram, Scorpio 25-30 gram, Scolopendra 25-30 gram, Rhizoma Typhonii 15-20 gram, Agkistrodon 15-20 gram, Rhizoma Gastrodiae 15-20 gram, Ganoderma 15-20 gram, Bombyx Batryticatus 15-20 gram, Hirudo 25-30 gram, Squama Manis 20-30 gram processed, Moschus 10-15 gram, Radix Ginseng Rubra 15-0 gram, Radix Curcumae 15-20 gram, 15 1 20 grams of Rhizoma Chuanxiongs, 25 1 30 grams of Radix Salviae Miltiorrhizaes, 15 1 20 grams of compositions of Rhizoma Corydalis.Publication number CN 101524521 A(application numbers 200810101486.2) Chinese patent literature a kind of Chinese medicine composition for the treatment of coronary heart disease is disclosed, made by Radix Glycyrrhizae Preparata, Rhizoma Polygonati Odorati, the Radix Paeoniae Alba, Cortex Acanthopancis, Radix Ophiopogonis, Radix Codonopsis, long-pending reality, Poria, Rhizoma Zingiberis, Endothelium Corneum Gigeriae Galli, Ramulus Cinnamomi, the Radix Rehmanniae, Radix Bupleuri, Colla Corii Asini, Radix Stephaniae Tetrandrae, CHUANSHAO, Radix Adenophorae (Radix Glehniae), Herba Leonuri, Radix Angelicae Sinensis, Radix Astragali Preparata and/or pharmaceutically acceptable carrier.Granted publication CN 1970069(application number 200610170280.6) Chinese patent literature a kind of medicine pill for the treatment of coronary heart disease is disclosed, it is taking 30 kinds of Chinese herbal medicine such as the Radix Astragali, Radix Rehmanniae Preparata, Radix Angelicae Sinensis, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Herba Taxilli, Fructus Trichosanthis, Rhizoma Corydalis, Radix Paeoniae, Rhizoma Anemones Altaicae, Caulis Spatholobi, Rhizoma Polygonati, Semen Sesami Nigrum, Semen Cuscutae, the Rhizoma Atractylodis Macrocephalae, Radix Curcumae, Radix Polygoni Multiflori Preparata, Herba Epimedii, Semen Ziziphi Spinosae, Fructus Schisandrae Chinensis, Colla Corii Asini, Ganoderma, Poria, Rhizoma Sparganii, Rhizoma Curcumae, Radix Ophiopogonis, Concha Ostreae, Radix Codonopsis, Lignum Santali Albi, Radix Glycyrrhizaes as raw material, adds that Mel modulation forms by pulverizing.
In a word, Chinese medicine is being obtained good curative effect aspect treatment primary disease, but also there are some problems: desirable not enough to the quick-acting vasodilative effects of acute blood supply insufficiency clinically, have much room for improvement to improving Electrocardiographic curative effect, to preventing and treating the factor of sending out well of coronary heart disease, as hypertension, hyperlipemia, diabetes also need synchronous research, the arrhythmia that coronary heart disease is occurred also awaits further raising as the curative effect such as premature beat, atrial fibrillation.
Summary of the invention
For the deficiencies in the prior art, the object of this invention is to provide and a kind ofly prepare simple, taking convenience, be easy to carry, easy Chinese medicine composition of the treatment coronary heart disease of clothes and preparation method thereof for a long time.This Chinese medicine composition determined curative effect and having no side effect.
Technical scheme of the present invention is:
The Chinese medicine composition for the treatment of myocardial infarction, is prepared from by following bulk drugs, is weight portion: Radix Curcumae 6-15, Fructus Hordei Germinatus 20-45, Lignum Dalbergiae Odoriferae 2-6, Radix Ophiopogonis 6-15, Concha Margaritifera 12-18, Lignum Aquilariae Resinatum 2-8, Rhizoma Polygoni Cuspidati 9-25, Radix Platycodonis 3-9, Sanguis Draxonis 2-6, Colla Corii Asini 6-12, Rhizoma Polygonati Odorati 5-12, Radix Panacis Quinquefolii 2-6, Radix Astragali 20-45, Stigma Croci 2-6, Radix Salviae Miltiorrhizae 20-45, Fructus Trichosanthis 20-45, Moschus 0.03-0.1.
In preferred scheme, Radix Curcumae 9-12, Fructus Hordei Germinatus 25-40, Lignum Dalbergiae Odoriferae 3-5, Radix Ophiopogonis 9-12, Concha Margaritifera 14-16, Lignum Aquilariae Resinatum 3-6, Rhizoma Polygoni Cuspidati 12-20, Radix Platycodonis 4-6, Sanguis Draxonis 3-5, Colla Corii Asini 8-10, Rhizoma Polygonati Odorati 6-10, Radix Panacis Quinquefolii 3-5, Radix Astragali 25-40, Stigma Croci 3-5, Radix Salviae Miltiorrhizae 25-40, Fructus Trichosanthis 25-40, Moschus 0.05-0.08.
Be more preferably Radix Curcumae 10, Fructus Hordei Germinatus 30, Lignum Dalbergiae Odoriferae 4, Radix Ophiopogonis 10, Concha Margaritifera 15, Lignum Aquilariae Resinatum 4, Rhizoma Polygoni Cuspidati 16, Radix Platycodonis 5, Sanguis Draxonis 4, Colla Corii Asini 9, Rhizoma Polygonati Odorati 8, Radix Panacis Quinquefolii 4, the Radix Astragali 35, Stigma Croci 4, Radix Salviae Miltiorrhizae 35, Fructus Trichosanthis 35, Moschus 0.06.
The present invention also provides the preparation method of aforementioned Chinese medicine composition being made to pharmaceutically acceptable water preparation, powder, tablet or capsule.
The preparation method of described water preparation is:
(1) Radix Curcumae, Fructus Hordei Germinatus, Lignum Dalbergiae Odoriferae, Radix Ophiopogonis, Concha Margaritifera, Lignum Aquilariae Resinatum, Rhizoma Polygoni Cuspidati, Radix Platycodonis, Sanguis Draxonis, Colla Corii Asini, Rhizoma Polygonati Odorati, Radix Panacis Quinquefolii, the Radix Astragali, Stigma Croci, Radix Salviae Miltiorrhizae and Fructus Trichosanthis are pulverized, crossed 120-140 mesh sieve (preferably 130 mesh sieves), obtain fine powder;
(2) by step (1) gained fine powder mix homogeneously, be placed in penetrating bag, be 6-8 hour (preferably 7 hours) of cold water immersion of 20-40 DEG C (preferably 30 DEG C) by temperature, water consumption is doubly (preferably 3.5 times) of 3-4 of described fine powder weight;
(3) be heated to boiling, after lasting 0.6-1.2 hour (preferably 0.8-1.0 hour), take out penetrating bag, gained liquid, through being concentrated into the 1/2-1/3 of original volume, obtains concentrated solution;
(4) will after Moschus grinding, add in the concentrated solution of step (3) gained, sterile packaged, obtains Chinese medicine composition water preparation.
The preparation method of described powder is: each crude drug was pulverized to 60-100 mesh sieve (preferably 80-85 mesh sieve), obtain Chinese medicine composition medicinal powder.
The preparation method of described tablet is: claim 6 gained Chinese medicine composition medicinal powder, according to 0.2-0.3g/ sheet (preferably 0.25g/ sheet) metering, is pressed into circular or other forms of lamellar dosage form according to the preparation for processing of tablet.
The preparation method of described tablet is: claim 6 gained Chinese medicine composition medicinal powder, according to 0.2-0.3g/ grain (preferably 0.25g/ grain) metering, is processed into capsule shape dosage form according to the preparation for processing of capsule.
The application of Chinese medicine composition described in the present invention also provides in the time of preparation treatment myocardial infarction, myocardial necrosis, anginal medicine.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Concha Margaritifera: nature and flavor: salty, cold.Gui Jing: return liver, heart channel.Effect: suppressing the hyperactive liver and subsiding YANG, arresting convulsion improving eyesight.Cure mainly: dizzy for having a headache. irritated insomnia, liver-heat conjunctival congestion, deficiency of the liver blurred vision." Chinese medicine voluminous dictionary ": this thing (Concha Margaritifera) double enter the heart, liver two warps, from Concha Haliotidis but enter Liver Channel person is different, thus relate to mind patient, this.
Lignum Aquilariae Resinatum: nature and flavor: pungent, bitter, tepor.Gui Jing: return spleen, stomach, kidney channel.Effect: promoting the circulation of QI to relieve pain, warming middle-JIAO to arrest vomiting, helping inspiration to relieve asthma.Cure mainly: for the vexed pain of breast abdominal distention, gastrofrigid vomiting singultus, the QI rising in reverse order of suffering from a deficiency of the kidney dyspnea with rapid respiration.
Rhizoma Polygoni Cuspidati: nature and flavor: micro-hardship, is slightly cold.Gui Jing: return liver, gallbladder, lung meridian.Effect: expelling wind and removing dampness, dissipating blood stasis analgesic therapy, relieving cough and resolving phlegm.Cure mainly: for arthralgia, jaundice due to damp-heat, amenorrhea ， mass in the abdomen, burn due to hot liquid or fire, injury from falling down, carbuncle sore tumefacting virus, cough with copious phlegm.
Radix Platycodonis: nature and flavor: bitter, pungent, flat.Gui Jing: return lung meridian.Effect: lung qi dispersing, sore-throat relieving, eliminates the phlegm, evacuation of pus.Cure mainly: for cough with copious phlegm, uncomfortable in chest not smooth, pharyngalgia, hoarseness, lung abscess vomiting pus, skin infection difficulty in discharging of pus.
Sanguis Draxonis: nature and flavor: sweet, salty, flat.Gui Jing: GUIXIN, Liver Channel.Effect: removing blood stasis and relieving pain, hemostasia and promoting granulation.Cure mainly: lose ecchymoma due to internal injury for falling to flutter; Continuous bleeding due to traumatic injury.
Colla Corii Asini: nature and flavor: sweet, flat.Gui Jing: return lung, liver, kidney channel.Effect: the YIN nourishing of enriching blood, moisturize hemostasis.Cure mainly: for blood deficiency and yellow complexion, dizzy cardiopalmus, flesh flaccidity is unable, dysphoria and insomnia, stirring-up of pathogenic wind in the interior resulting from deficiency, xeropulmonary cough, chronic cough spitting of blood, haematemesis hematuria, the metrorrhagia of having blood in stool, vaginal bleeding during pregnancy.
Rhizoma Polygonati Odorati: nature and flavor: sweet, be slightly cold.Gui Jing: attach to the lung and stomach meridians.Effect: nourishing YIN to relieve dryness, promoting the production of body fluid to quench thirst.Cure mainly: for lung stomach-Yin wound, cough caused by dryness-heat, swallows in thirsty, and interior-heat is quenched one's thirst.
Radix Panacis Quinquefolii: sweet, the micro-hardship of property, cool.GUIXIN, lung, kidney channel.There is effect of boosting qi and nourishing yin, clearing away heat and promoting production of body fluid.Lose for the deficiency of vital energy is cloudy, interior-heat, cough with asthma expectorant blood, deficiency-heat is tired tired, quenches one's thirst, dryness of the mouth and throat.Radix Panacis Quinquefolii has the effect of resisting fatigue, antioxidation, anti-stress, anticoagulant, reduction blood coagulation, in addition, diabetics is regulated in addition to the effect of blood glucose.
The Radix Astragali: property is sweet, tepor.Return lung, spleen, liver, kidney channel.There is effect that benefiting QI for strengthening the superficies, arresting sweating are admittedly de-, hold in the palm skin ulcer granulation promoting, inducing diuresis to remove edema.Be generally used for the treatment deficiency of vital energy weak, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, the metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, carbuncle is difficult bursts, and burst and do not hold back for a long time, blood deficiency and yellow complexion, interior-heat is quenched one's thirst, chronic nephritis, albuminuria, diabetes etc.
Stigma Croci: nature and flavor: sweet, flat.Gui Jing: GUIXIN, Liver Channel.Effect: blood circulation promoting and blood stasis dispelling, removing pathogenic heat from blood and toxic substance from the body, resolving stagnation for tranquilization.Cure mainly: for amenorrhea and mass in the abdomen, postpartum stagnation, maculae caused by violent heat pathogen, melancholy painful abdominal mass is vexed, and palpitation with fear is gone mad.
Radix Salviae Miltiorrhizae: nature and flavor hardship, cold nature.Energy blood circulation promoting and blood stasis dispelling, removing heat from blood, calms the nerves.Enter the heart, spleen two warps.According to " book on Chinese herbal medicine is looked for the truth ": Radix Salviae Miltiorrhizae has the effect into percardium removing blood stasis with potent drugs.Modern medicine study confirms, its energy coronary artery dilator, and increase coronary flow, improves myocardial ischemia, infraction and cardiac function, regulates the rhythm of the heart, and can expand peripheral blood vessel, improves microcirculation; Can improve body's hypoxia tolerance; There is anticoagulation, promote fibrinolytic, suppress platelet aggregation, suppress thrombotic effect; Can reduce blood fat, suppress coronary atherosclerosis and form; Can shorten the convalescent period of erythrocyte and hematochrome, Reticulocyte is increased, can promote the reparation of tissue, accelerate the healing of fracture; There is nervus centralis to have inhibitory action; There is antitumor action; Energy enhancing human body immunity function; Can reduce blood glucose; The various bacteria such as tubercule bacillus are had to inhibitory action.
Radix Ophiopogonis: nature and flavor: sweet, micro-hardship, is slightly cold.Gui Jing: GUIXIN, lung, stomach warp.Effect: YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire.Cure mainly: for dryness of the lung dry cough.Chronic consumptive disease cough, Tianjin wound is thirsty, vexed insomnia, interior-heat is quenched one's thirst, dryness of the intestine constipation; Pharyngeal diphtheria.
Fructus Trichosanthis (son): cold in nature, sweet in the mouth, micro-hardship.Return lung, stomach, large intestine channel.Clearing away heat and eliminating phlegm, relieving stuffiness of the chest by dispersing aggregation of pathogens, moisturizes laxation.For cough due to lung-heat, the turbid Huang of expectorant is thick, obstruction of qi in the chest and cardialgia, and blocked-up chest feeling of fullness, acute mastitis, lung abscess, acute appendicitis swells and ache, constipation.Modern medicine and pharmacology studies have shown that: Fructus Trichosanthis has expansion heart arteria coronaria, increases coronary flow effect; Acute myocardial ischemia is had to significant protective effect.
Radix Curcumae: property is pungent, bitter, cold.Return liver, the heart, lung meridian.Can regulating qi to disperse stagnation, heart fire-clearing upset-relieving, promoting the function of the gallbladder to alleviate jaundice.Be generally used for amenorrhea dysmenorrhea, chest and abdomen swelling and pain, twinge, calentura coma, epilepsy is gone mad, jaundice dark coloured urine.
Lignum Dalbergiae Odoriferae: property is pungent, temperature.Return liver, spleen channel.There is promoting flow of QI and blood, pain relieving, hemostasia effect.Be generally used for epigastric pain, hypochondriac pain due to stagnation of liverQI, thoracic obstruction twinge, injury from falling down, traumatic hemorrhage.
Fructus Hordei Germinatus nature and flavor: sweet, flat.Gui Jing: return spleen, stomach warp.Effect: spleen benefiting and stimulating the appetite, moves back newborn relieving distension.Cure mainly: do not disappear for food stagnation, women's ablactation, Fructus Hordei Germinatus (parched to brown) relieving dyspepsia.Do not disappear for food stagnation, abdominal distention.
Moschus (preferably natural Moschus): nature and flavor: pungent, temperature.Gui Jing: GUIXIN, spleen channel.Effect: the refreshment of having one's ideas straightened out, promoting blood circulation to restore menstrual flow, reducing swelling and alleviating pain.Cure mainly: for calentura coma, apoplexy syncope due to accumulation of phlegm, stagnation of QI sudden syncope, attacked by pestiferous factors stupor, amenorrhea ， mass in the abdomen, difficult labour stillborn fetus, trusted subordinate's sudden pain, carbuncle scrofula, laryngopharynx swelling and pain, falls and flutters the pain of injury, arthralgia pain numbness.
Chinese medicine composition prescription science provided by the invention, the preparation method of various dosage forms is simple, products obtained therefrom taking convenience, is easy to carry.In addition, excellent results of the present invention also shows:
1,selected materials is all Chinese medicine material, without any side effects;
2,this prescription meets Chinese medicine principle and cardiac's body and mind feature completely, under the prerequisite of general principle, can have different prescriptions according to different crowd, function difference.
3,medicine source is easy to get, and medical material is with low cost, can relieve patient ' s burden.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited to this.
embodiment 1the Chinese medicine composition for the treatment of coronary heart disease, is prepared from by following bulk drugs: Radix Curcumae 6g, Fructus Hordei Germinatus 20 g, Lignum Dalbergiae Odoriferae 2 g, Radix Ophiopogonis 6 g, Concha Margaritifera 12 g, Lignum Aquilariae Resinatum 2 g, Rhizoma Polygoni Cuspidati 9 g, Radix Platycodonis 3 g, Sanguis Draxonis 2 g, Colla Corii Asini 6 g, Rhizoma Polygonati Odorati 5 g, Radix Panacis Quinquefolii 2 g, the Radix Astragali 20 g, Stigma Croci 2 g, Radix Salviae Miltiorrhizae 20 g, Fructus Trichosanthis 20 g, Moschus 0.03 g.
The preparation method of the Chinese medicine composition water preparation of above-mentioned treatment coronary heart disease:
(1) Radix Curcumae, Fructus Hordei Germinatus, Lignum Dalbergiae Odoriferae, Radix Ophiopogonis, Concha Margaritifera, Lignum Aquilariae Resinatum, Rhizoma Polygoni Cuspidati, Radix Platycodonis, Sanguis Draxonis, Colla Corii Asini, Rhizoma Polygonati Odorati, Radix Panacis Quinquefolii, the Radix Astragali, Stigma Croci, Radix Salviae Miltiorrhizae and Fructus Trichosanthis are pulverized, crossed 140 mesh sieves, obtain fine powder;
(2) by step (1) gained fine powder mix homogeneously, be placed in penetrating bag, be the cold water immersion 8 hours of 40 DEG C by temperature, water consumption is 4 times of described fine powder weight;
(3) be heated to boiling, continue to take out after 1.2 hours penetrating bag, gained liquid, through being concentrated into the 1/2-1/3 of original volume, obtains concentrated solution;
(4) will after Moschus grinding, add in the concentrated solution of step (3) gained, sterile packaged, obtains Chinese medicine composition water preparation.
The instructions of taking of water preparation of the present invention: water preparation is 7 days courses for the treatment of, takes twice (warm) every day, each 350m1-500m1.
embodiment 2the Chinese medicine composition for the treatment of coronary heart disease, is prepared from by following bulk drugs: Radix Curcumae 15g, Fructus Hordei Germinatus 45 g, Lignum Dalbergiae Odoriferae 6 g, Radix Ophiopogonis 15 g, Concha Margaritifera 18 g, Lignum Aquilariae Resinatum 8 g, Rhizoma Polygoni Cuspidati 25 g, Radix Platycodonis 9 g, Sanguis Draxonis 6 g, Colla Corii Asini 12 g, Rhizoma Polygonati Odorati 12 g, Radix Panacis Quinquefolii 6 g, the Radix Astragali 45 g, Stigma Croci 6 g, Radix Salviae Miltiorrhizae 45 g, Fructus Trichosanthis 45 g, Moschus 0.1 g.
The preparation method of the Chinese medicine composition medicinal powder for the treatment of coronary heart disease is: each crude drug was pulverized to 100 mesh sieves, obtain Chinese medicine composition medicinal powder, and divided 0.4g/ bag by powder.Adopt every day 2-3 time, each one bag, use warm boiled water, 7 days courses for the treatment of.
Model case: xxx, the age: 46 years old; Sex: women; Main suit: intermittent chest pain 3 months; History of present illness: patient occurred before 6 hours, without obvious inducement chest pain, for vexed pain after breastbone, being persistence, the radiation of companion's back part, without abdominal distention, without stomachache, without nausea and vomiting, generates heat without fear of cold, without cough and expectoration.Discuss: the blood supply of electrocardio diagram coronary artery is obviously not enough, through checking the basic chest pain that other reasons causes of getting rid of, chest pain diagnosis is clear and definite due to coronary heart disease.
Take the Chinese medicine composition medicinal powder of the present embodiment gained treatment coronary heart disease, each one bag, every day 2 times, warm boiled water, 7 days courses for the treatment of.Take 21 days, chest pain obviously alleviates, and confusingly in the heart also alleviates, and the amount of receiving increases, spirit can, take 1 month, symptom is eliminated, the peace of sleeping night, vexed removing, strength increases, receive food can,, there is not any discomfort in following the service 2 months, the recovery from illness of patient's self-induction when patient takes.
embodiment 3the Chinese medicine composition for the treatment of coronary heart disease, is prepared from by following bulk drugs: Radix Curcumae 9g, Fructus Hordei Germinatus 25 g, Lignum Dalbergiae Odoriferae 3 g, Radix Ophiopogonis 9 g, Concha Margaritifera 14 g, Lignum Aquilariae Resinatum 3 g, Rhizoma Polygoni Cuspidati 12 g, Radix Platycodonis 4 g, Sanguis Draxonis 3 g, Colla Corii Asini 8 g, Rhizoma Polygonati Odorati 6 g, Radix Panacis Quinquefolii 3 g, the Radix Astragali 25 g, Stigma Croci 3 g, Radix Salviae Miltiorrhizae 25 g, Fructus Trichosanthis 25 g, Moschus 0.05 g.
The preparation method of the Chinese medicine composition tablet for the treatment of coronary heart disease is: each crude drug was pulverized to 60 mesh sieves, obtain Chinese medicine composition medicinal powder, gained Chinese medicine composition medicinal powder, according to the metering of 0.25g/ sheet, is pressed into circular or other forms of lamellar dosage form according to the preparation for processing of tablet.Tablet adopts every day twice, each 2-4 sheet, and with warm boiled water, 7 days courses for the treatment of.
Model case: xxx, male, 56 years old.Precordial dull pain is had a surplus for 2 years, and every day, pain outbreak 2-5 time, could alleviate containing nitroglycerin.Have uncomfortable in chest, be afraid of cold, cardiopalmus, extremities being not warm is warm, fatigue and weak, the lower limb soreness of waist that swells, the diseases such as chest pain radiating to the back.Electrocardio diagram coronary insufficiency.B ultrasonic shows merging ventricular aneurysm.Deep-slow pulse, white and thin fur.
The Chinese medicine composition tablet of taking the present embodiment gained treatment coronary heart disease, adopts every day twice, and each 4, with warm boiled water, 7 days courses for the treatment of.Take 21 days, precordialgia obviously alleviates, and fatigue and weak also alleviates, and the amount of receiving increases, spirit can, take 1 month, the blood supply of electrocardio diagram coronary artery obviously improves, following the service 4 months, patient's recovery from illness.
embodiment 4the Chinese medicine composition for the treatment of coronary heart disease, is prepared from by following bulk drugs: Radix Curcumae 12g, Fructus Hordei Germinatus 40 g, Lignum Dalbergiae Odoriferae 5 g, Radix Ophiopogonis 12 g, Concha Margaritifera 16 g, Lignum Aquilariae Resinatum 6 g, Rhizoma Polygoni Cuspidati 20 g, Radix Platycodonis 6 g, Sanguis Draxonis 5 g, Colla Corii Asini 10 g, Rhizoma Polygonati Odorati 10 g, Radix Panacis Quinquefolii 5 g, the Radix Astragali 40 g, Stigma Croci 5 g, Radix Salviae Miltiorrhizae 40 g, Fructus Trichosanthis 40 g, Moschus 0.08 g.
The preparation method of the Chinese medicinal composition capsules agent for the treatment of coronary heart disease is: each crude drug was pulverized to 80 mesh sieves, obtain Chinese medicine composition medicinal powder, gained Chinese medicine composition medicinal powder, according to the metering of 0.25g/ grain, is processed into capsule shape dosage form according to the preparation for processing of capsule.
Model case: xxx, 60 years old, man, occur compared with more acutely and frequently angina pectoris in the past one day, the angina pectoris persistent period is longer, and inducement is not obvious, takes nitroglycerin, but weak curative effect, when angina pectoris attacks with feeling sick, vomiting, profuse sweating, bradycardia, acute cardiac insufficiency, severe arrhythmia.
The Chinese medicinal composition capsules agent of taking the present embodiment gained treatment coronary heart disease, adopts every day twice, and each 4, with warm boiled water, 7 days courses for the treatment of.Take 21 days, angina pectoris obviously alleviates, and feels sick, symptoms of emesis disappears, and the amount of receiving increases, spirit can, take 1 month, the blood supply of electrocardio diagram coronary artery obviously improves, following the service 3 months, patient's recovery from illness.
embodiment 5the Chinese medicine composition for the treatment of coronary heart disease, is prepared from by following bulk drugs: Radix Curcumae 10g, Fructus Hordei Germinatus 30 g, Lignum Dalbergiae Odoriferae 4 g, Radix Ophiopogonis 10 g, Concha Margaritifera 15 g, Lignum Aquilariae Resinatum 4 g, Rhizoma Polygoni Cuspidati 16 g, Radix Platycodonis 5 g, Sanguis Draxonis 4 g, Colla Corii Asini 9 g, Rhizoma Polygonati Odorati 8 g, Radix Panacis Quinquefolii 4 g, the Radix Astragali 35 g, Stigma Croci 4 g, Radix Salviae Miltiorrhizae 35 g, Fructus Trichosanthis 35 g, Moschus 0.06 g.
The preparation method of the Chinese medicine composition water preparation for the treatment of coronary heart disease is:
(1) Radix Curcumae, Fructus Hordei Germinatus, Lignum Dalbergiae Odoriferae, Radix Ophiopogonis, Concha Margaritifera, Lignum Aquilariae Resinatum, Rhizoma Polygoni Cuspidati, Radix Platycodonis, Sanguis Draxonis, Colla Corii Asini, Rhizoma Polygonati Odorati, Radix Panacis Quinquefolii, the Radix Astragali, Stigma Croci, Radix Salviae Miltiorrhizae and Fructus Trichosanthis are pulverized, crossed 130 mesh sieves, obtain fine powder;
(2) by step (1) gained fine powder mix homogeneously, be placed in penetrating bag, be the cold water immersion 7 hours of 30 DEG C by temperature, water consumption is 3.5 times of described fine powder weight;
(3) be heated to boiling, continue to take out after 1.0 hours penetrating bag, gained liquid, through being concentrated into the 1/2-1/3 of original volume, obtains concentrated solution;
(4) will after Moschus grinding, add in the concentrated solution of step (3) gained, sterile packaged, obtains Chinese medicine composition water preparation.
test example 1the clinical practice of the Chinese medicine composition water preparation of embodiment 5 gained treatment coronary heart disease: in June, 2008-2011 year December, screens 120 routine patients in 4 hospitals, wherein women's 58 examples, male's 62 examples, oldest 72 years old, minimal ages 38 years old, 55.2 years old mean age.Test 2 weeks before, carries out Continuous Observation to this crowd, records symptom and variation, be divided at random two groups, experimental group and matched group, experimental group is taken embodiment 5 products obtained therefroms, and matched group is taken other medicine (the conventional medicine such as metoprolol, lignocaine, norepinephrine).Using method is: take every day twice (warm), each 350m1-500m1(adjusts to some extent depending on concrete condition), 7 days courses for the treatment of.Curative effect situation criterion: cure: take a course for the treatment of of this product, the blood supply of electrocardio diagram coronary artery obviously improves, and malaise symptoms disappears, and energy and muscle power obviously strengthen; Effective: take a course for the treatment of of this product, electrocardio illustrates chronic coronary artery blood supply to be improved, and malaise symptoms alleviates or part disappears, and energy and muscle power strengthen; Invalid: take a course for the treatment of of this product, malaise symptoms is unchanged.Result is as shown in table 1.
Table 1: take embodiment 5 product 38-72 year Treatment in Patients with Coronary Heart results
| Experimental group | Matched group | |
| Number of cases | 100 | 20 |
| Male's number of cases | 52 | 10 |
| Women's number of cases | 48 | 10 |
| Age (year) | 38-72 | 38-72 |
| Clinical cure number of cases | 72 | 5 |
| Effectively number of cases | 27 | 11 |
| Invalid number of cases | 1 | 4 |
| Total effective rate | 99% | 80% |
Therapeutic effect: cure 72 examples (72%), effective 27 examples (27%), invalid 1 example (1%), total effective rate 99%.Successful is better than matched group.
During taking, self-induction symptom and physical change of spirit thereof are as shown in table 2.
Table 2:
The present invention selects Radix Panacis Quinquefolii, Fructus Trichosanthis, Radix Curcumae, Fructus Hordei Germinatus, Lignum Dalbergiae Odoriferae etc. to carry out compatibility, makes after these drug regimens to produce synergism, can more effectively treat coronary heart disease.In side, Radix Salviae Miltiorrhizae, Radix Curcumae, Lignum Dalbergiae Odoriferae, Stigma Croci master are at blood circulation promoting and blood stasis dispelling, removing obstruction in the collateral to relieve pain; Radix Panacis Quinquefolii, the Radix Astragali, Radix Ophiopogonis Replenishing QI and nourishing YIN, hold up this training unit; Fructus Trichosanthis a surname numbness the chest stuffiness relieving; Moschus is warded off and is dirtyly had one's ideas straightened out.Concha Margaritifera, Lignum Aquilariae Resinatum, Rhizoma Polygoni Cuspidati, Radix Platycodonis, Sanguis Draxonis, Rhizoma Polygonati Odorati are for the vexed pain of breast abdominal distention, expelling wind and removing dampness, dissipating blood stasis analgesic therapy, nourishing YIN to relieve dryness; Colla Corii Asini nourishing blood YIN nourishing.All medicines share, and invigorate blood circulation and can yin nourishing, and blood stasis dispelling and just not hindering, has one's ideas straightened out and the QI invigorating of holding concurrently, therefore can obtain good therapeutic effect.Take 10 days, more than 53% feeling takes a turn for the better to some extent, and malaise symptoms improves; Take 20 days, more than 72% feeling takes a turn for the better to some extent, and malaise symptoms improves or disappears, and spirit, muscle power strengthen; Take 30 days, more than 97% feeling takes a turn for the better to some extent, and malaise symptoms improves or disappears, and spirit, muscle power strengthen, and the blood supply of electrocardio diagram coronary artery obviously improves, the recovery from illness of some patients were self-induction.In experimental group, take more than 30 days, effective percentage can reach 93%, and matched group is only 76%.
The application's prescription is distinguished veteran doctors of TCM proved recipe, and has passed through Liaocheng University, Liaocheng City hospital of traditional Chinese hospital experts and scholars' demonstration, has the prospect of industrialized implementation.Present inventor is the employee of the Shandong institute of political science and law (speaker's inventive science), and completing of this invention has benefited from Shandong Province's 12 Planning emphasis subjects---the support of Law of Economy subject fund.
It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clearly disclosed or according to undoubted the obtaining of the written description of file, all should think the claimed scope of this patent.
Claims (5)
1. the preparation method of the Chinese medicine composition tablet for the treatment of coronary heart disease, is characterized in that, is prepared from: Radix Curcumae 6-15g, Fructus Hordei Germinatus 20-45g by following bulk drugs, Lignum Dalbergiae Odoriferae 2-6g, Radix Ophiopogonis 6-15g, Concha Margaritifera 12-18g, Lignum Aquilariae Resinatum 2-8g, Rhizoma Polygoni Cuspidati 9-25g, Radix Platycodonis 3-9g, Sanguis Draxonis 2-6g, Colla Corii Asini 6-12g, Rhizoma Polygonati Odorati 5-12g, Radix Panacis Quinquefolii 2-6g, Radix Astragali 20-45g, Stigma Croci 2-6g, Radix Salviae Miltiorrhizae 20-45g, Fructus Trichosanthis 20-45g, Moschus 0.03-0.1g; Each crude drug was pulverized to 60-100 mesh sieve, obtained Chinese medicine composition medicinal powder; Gained Chinese medicine composition medicinal powder, according to the metering of 0.2-0.3g/ sheet, is pressed into circular or other forms of lamellar dosage form according to the preparation for processing of tablet.
2. preparation method as claimed in claim 1, is characterized in that, each crude drug composition: Radix Curcumae 9-12g, Fructus Hordei Germinatus 25-40g, Lignum Dalbergiae Odoriferae 3-5g, Radix Ophiopogonis 9-12g, Concha Margaritifera 14-16g, Lignum Aquilariae Resinatum 3-6g, Rhizoma Polygoni Cuspidati 12-20g, Radix Platycodonis 4-6g, Sanguis Draxonis 3-5g, Colla Corii Asini 8-10g, Rhizoma Polygonati Odorati 6-10g, Radix Panacis Quinquefolii 3-5g, Radix Astragali 25-40g, Stigma Croci 3-5g, Radix Salviae Miltiorrhizae 25-40g, Fructus Trichosanthis 25-40g, Moschus 0.05-0.08g.
3. preparation method as claimed in claim 1, is characterized in that, each crude drug composition: Radix Curcumae 10g, Fructus Hordei Germinatus 30g, Lignum Dalbergiae Odoriferae 4g, Radix Ophiopogonis 10g, Concha Margaritifera 15g, Lignum Aquilariae Resinatum 4g, Rhizoma Polygoni Cuspidati 16g, Radix Platycodonis 5g, Sanguis Draxonis 4g, Colla Corii Asini 9g, Rhizoma Polygonati Odorati 8g, Radix Panacis Quinquefolii 4g, Radix Astragali 35g, Stigma Croci 4g, Radix Salviae Miltiorrhizae 35g, Fructus Trichosanthis 35g, Moschus 0.06g.
4. preparation method as claimed in claim 1, is characterized in that, each crude drug was pulverized to 80-85 mesh sieve.
5. preparation method as claimed in claim 1, is characterized in that, by gained Chinese medicine composition medicinal powder according to selecting 0.25g/ sheet metering.
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