CN103285327A - Traditional Chinese medicine composition tablet for treating coronary heart diseases and preparation method thereof - Google Patents
Traditional Chinese medicine composition tablet for treating coronary heart diseases and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition tablet for treating coronary heart diseases. The capsule is prepared from the following active pharmaceutical ingredients in parts by weight: 6-15 parts of turmeric root tuber, 20-45 parts of barley malt, 2-6 parts of rosewood, 6-15 parts of dwarf lilyturf tuber, 12-18 parts of nacre, 2-8 parts of agilawood, 9-25 parts of giant knotweed rhizome, 3-9 parts of platycodon root, 2-6 parts of draconis resin, 6-12 parts of ass hide glue, 5-12 parts of fragrant solomonseal rhizome, 2-6 parts of American ginseng, 20-45 parts of radix astragali, 2-6 parts of saffron, 20-45 parts of salvia miltiorrhiza, 20-45 parts of snake gourd fruit and 0.03-0.1 part of musk. The tablet has the excellent effects that all the selected materials are traditional Chinese medicine materials and do not have any toxic or side effects; the prescription completely conforms to the principles of the traditional Chinese medicines and the physical and mental characteristics of patients with heart diseases; on the premise of general principles, different prescriptions can be provided to different crowds and have different functions; and the medicine sources are easy to obtain, the medicine cost is low, and the burdens of patients can be reduced.
Description
The application is for dividing an application: the original bill application number: 201210091229.1, and the applying date: 2012.3.31, denomination of invention: Chinese medicine composition for the treatment of coronary heart disease and preparation method thereof.
Technical field
The present invention relates to the Chinese medicine field, particularly relate to a kind of Chinese medicine composition for the treatment of coronary heart disease and preparation method thereof.
Background technology
Coronary atherosclerotic heart disease (hereinafter to be referred as coronary heart disease) is owing to selenium shape atherosclerosis causes myocardial ischemia, the caused heart disease of anoxia.And 95% above myocardial infarction is many to be formed by the coronary heart disease development, and the acute myocardial infarction mortality rate is very high, mostly 30%～40%, is the commonly encountered diseases of serious threat human life, health.
Coronary heart disease generally belongs to categories such as the traditional Chinese medical science " thoracic obstruction ", " precordial pain with cold limbs ", " angina pectoris ".Just on the books in Huangdi's Internal Classics: " pained person, chest pain, discomfort and fullness in the hypochondrium, pain over the hypochondrium is born pain between back of the body shoulder blade." and for example " Ling Shu Miraculous Pivot or Divine Axis faint disease " piece of writing say: " angina pectoris, bluish colour of the limbs extending up to the elbows and knees, very pained.Onset of disease in the morning and dying in the evening, onset of disease in the evening and dying in the next morning." quite similar angina pectoris and myocardial infarction.The Han dynasty Zhang Zhongjing waits at " Medical Treasures of the Golden Chamber obstruction of qi in the chest and cardialgia lose heart abnormal pulse card control " and has further made a series of arteries and veins cards in the chapter and describe, and the square medicine of proposition comparison system.As " pain over the chest and back is losed heart for the disease of the thoracic obstruction, dyspnea and expectoration, pulse at CUN KOU being deep and slow, GUAN being pulse faint, tense and rapid, Gualou Xiebai Baijiu Tang "; And for example " unable to tie down due to obstruction of QI in the chest, the chest pain radiating to the back person, the Gualou Xiebai Banxia Tang master it ".Ancient Chinese medicine doctor to all performances to some extent of dialectical, square medicine, has accumulated a whole set of Chinese medicine and has prevented and treated the clinical experience of coronary heart disease on this basis in the long term medical practice.
Modern TCM is to Study on Coronary Heart Disease, and clinical article sees nineteen fifty-five the earliest, proposes primary disease and is equivalent to the traditional Chinese medical science it " thoracic obstruction ", " angina pectoris ".The fifties, clinical discussion and basic research were few based on the case introduction.The sixties, clinical data increased gradually, the etiology and pathogenesis of primary disease, treatment rule, differentiation of symptoms and signs for classification of syndrome, treatment side's medicine etc. are set forth to some extent, and obtained preliminary curative effect, but basic research still seldom; To the seventies clinical data and theoretic discussion showed increased, constantly holding of national academic conference promoted the research work development, and curative effect is improved constantly.Chinese medicine not only is applied to prevent and treat angina pectoris, also is used for rescuing acute myocardial infarction.This Tou has summed up more clinical experience period, and verification is controlled rule and explored.Method for the treatment of has determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, cipher prescription, folk prescription proved recipe, acupuncture, massage etc.The rule for the treatment of has blood circulation promoting and blood stasis dispelling, a surname's numbness, aromatic herbs activating YANG and supplementing QI and nourishing YIN is invigorated blood circulation, benefiting QI for activating blood circulation and set upright the kidney invigorating etc. activates yang.Aspect dialectical consistent generally acknowledge belong to syndrome of intermingled deficiency and excess mostly, it is this that internal organs lose that virtual work can lack of proper care, blood stasis, the stagnation of QI, expectorant are turbid, cold coagulation numbness resistance heart arteries and veins is mark.Form of Chinese drug is main quick-effective preparation and the expansion blood vessel Chinese medicine that develops into sheet, cream, ball, electuary, aerosol and injection, particularly allevating angina pectoris from decoction, has improved the clinical value for the treatment of by Chinese herbs coronary heart disease greatly.Acute myocardial infarction is rescued in the combination of Chinese and Western medicine makes the case fatality rate of primary disease be down to about 12% from 30%～40%.The basic research aspect finds that activating blood and removing stasis Method and blood circulation promoting medicine have the increase coronary flow, reduces myocardial oxygen consumption, anticoagulant and anticoagulant and thrombolytic, the effect of protection ischemic myocardium.Since the eighties, though the excavation of the new method of new drug is not many, existing side's medicine has further been affirmed curative effect, further investigation pharmacological action and analysis effective ingredient are done a lot of work.As studying to inquire into the mechanism of action of the blood circulation promoting and blood stasis dispelling rule for the treatment of from aspects such as hemorheology, microcirculation and cardiac inspections, and carried out antiatherogenic research etc.
Publication number CN 1498645A(application number 02148326.4) Chinese patent literature discloses a kind of cerebral infarction sequela and coronary heart disease Chinese medicinal capsule and manufacture method thereof of being used for the treatment of, this Chinese medicinal capsule is to be restrained by Pheretima 15-20, eupolyphage sece steleophaga 15-20 gram, Scorpio 25-30 gram, Scolopendra 25-30 gram, Rhizoma Typhonii 15-20 gram, Agkistrodon 15-20 gram, Rhizoma Gastrodiae 15-20 gram, Ganoderma 15-20 gram, Bombyx Batryticatus 15-20 gram, Hirudo 25-30 gram, Squama Manis 20-30 gram processed, Moschus 10-15 gram, Radix Ginseng Rubra 15-0 gram, Radix Curcumae 15-20 gram, Rhizoma Chuanxiong 15 1 20 grams, Radix Salviae Miltiorrhizae 25 1 30 grams, Rhizoma Corydalis 15 1 20 grams are formed.Publication number CN 101524521 A(application numbers 200810101486.2) Chinese patent literature discloses a kind of Chinese medicine composition for the treatment of coronary heart disease, is made by Radix Glycyrrhizae Preparata, Rhizoma Polygonati Odorati, the Radix Paeoniae Alba, Cortex Acanthopancis, Radix Ophiopogonis, Radix Codonopsis, long-pending reality, HUODENG, Rhizoma Zingiberis, Endothelium Corneum Gigeriae Galli, Ramulus Cinnamomi, the Radix Rehmanniae, Radix Bupleuri, Colla Corii Asini, Radix Stephaniae Tetrandrae, CHUANSHAO, Radix Adenophorae (Radix Glehniae), Herba Leonuri, Radix Angelicae Sinensis, Radix Astragali Preparata and/or pharmaceutically acceptable carrier.Granted publication CN 1970069(application number 200610170280.6) Chinese patent literature discloses a kind of medicine pill for the treatment of coronary heart disease, it is to be raw material with 30 kinds of Chinese herbal medicine such as the Radix Astragali, Radix Rehmanniae Preparata, Radix Angelicae Sinensis, Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Herba Taxilli, Fructus Trichosanthis, Rhizoma Corydalis, Radix Paeoniae, Rhizoma Anemones Altaicae, Caulis Spatholobi, Rhizoma Polygonati, Semen Sesami Nigrum, Semen Cuscutae, the Rhizoma Atractylodis Macrocephalae, Radix Curcumae, Radix Polygoni Multiflori Preparata, Herba Epimedii, Semen Ziziphi Spinosae, Fructus Schisandrae Chinensis, Colla Corii Asini, Ganoderma, Poria, rhizoma sparganic, Rhizoma Curcumae, Radix Ophiopogonis, Concha Ostreae, Radix Codonopsis, Lignum Santali Albi, Radix Glycyrrhizaes, adds by pulverizing that the Mel modulation forms.
In a word, Chinese medicine is being obtained curative effect preferably aspect the treatment primary disease, but also there are some problems: desirable not enough to the quick-acting vasodilative effects of acute blood supply insufficiency clinically, have much room for improvement to improving Electrocardiographic curative effect, to preventing and treating the factor of sending out well of coronary heart disease, also need research synchronously as hypertension, hyperlipemia, diabetes, arrhythmia such as curative effects such as premature beat, atrial fibrillation that coronary heart disease is occurred also await further raising.
Summary of the invention
At the deficiencies in the prior art, the purpose of this invention is to provide and a kind ofly prepare simple, taking convenience, be easy to carry, easy Chinese medicine composition of the treatment coronary heart disease of clothes and preparation method thereof for a long time.This Chinese medicine composition determined curative effect and having no side effect.
Technical scheme of the present invention is:
The Chinese medicine composition for the treatment of myocardial infarction is prepared from by following bulk drugs, is weight portion: Radix Curcumae 6-15, Fructus Hordei Germinatus 20-45, Lignum Dalbergiae Odoriferae 2-6, Radix Ophiopogonis 6-15, Concha Margaritifera 12-18, Lignum Aquilariae Resinatum 2-8, Rhizoma Polygoni Cuspidati 9-25, Radix Platycodonis 3-9, Sanguis Draxonis 2-6, Colla Corii Asini 6-12, Rhizoma Polygonati Odorati 5-12, Radix Panacis Quinquefolii 2-6, Radix Astragali 20-45, Stigma Croci 2-6, Radix Salviae Miltiorrhizae 20-45, Fructus Trichosanthis 20-45, Moschus 0.03-0.1.
In the preferred scheme, Radix Curcumae 9-12, Fructus Hordei Germinatus 25-40, Lignum Dalbergiae Odoriferae 3-5, Radix Ophiopogonis 9-12, Concha Margaritifera 14-16, Lignum Aquilariae Resinatum 3-6, Rhizoma Polygoni Cuspidati 12-20, Radix Platycodonis 4-6, Sanguis Draxonis 3-5, Colla Corii Asini 8-10, Rhizoma Polygonati Odorati 6-10, Radix Panacis Quinquefolii 3-5, Radix Astragali 25-40, Stigma Croci 3-5, Radix Salviae Miltiorrhizae 25-40, Fructus Trichosanthis 25-40, Moschus 0.05-0.08.
Be more preferably Radix Curcumae 10, Fructus Hordei Germinatus 30, Lignum Dalbergiae Odoriferae 4, Radix Ophiopogonis 10, Concha Margaritifera 15, Lignum Aquilariae Resinatum 4, Rhizoma Polygoni Cuspidati 16, Radix Platycodonis 5, Sanguis Draxonis 4, Colla Corii Asini 9, Rhizoma Polygonati Odorati 8, Radix Panacis Quinquefolii 4, the Radix Astragali 35, Stigma Croci 4, Radix Salviae Miltiorrhizae 35, Fructus Trichosanthis 35, Moschus 0.06.
The present invention also provides the preparation method of aforementioned Chinese medicine composition being made pharmaceutically acceptable water preparation, powder, tablet or capsule.
The preparation method of described water preparation is:
(1) Radix Curcumae, Fructus Hordei Germinatus, Lignum Dalbergiae Odoriferae, Radix Ophiopogonis, Concha Margaritifera, Lignum Aquilariae Resinatum, Rhizoma Polygoni Cuspidati, Radix Platycodonis, Sanguis Draxonis, Colla Corii Asini, Rhizoma Polygonati Odorati, Radix Panacis Quinquefolii, the Radix Astragali, Stigma Croci, Radix Salviae Miltiorrhizae and Fructus Trichosanthis are pulverized, crossed 120-140 mesh sieve (preferred 130 mesh sieves), get fine powder;
(2) with step (1) gained fine powder mix homogeneously, place in the penetrating bag, be 6-8 hour (preferred 7 hours) of cold water immersion of 20-40 ℃ (preferred 30 ℃) with temperature, water consumption is 3-4 times (preferred 3.5 times) of described fine powder weight;
(3) be heated to boiling, penetrating bag is taken out in (preferred 0.8-1.0 hour) back to continue 0.6-1.2 hour, and gained liquid gets concentrated solution through being concentrated into the 1/2-1/3 of original volume;
(4) will add in the concentrated solution of step (3) gained after the Moschus grinding, sterile packaged namely gets the Chinese medicine composition water preparation.
The preparation method of described powder is: each crude drug was pulverized 60-100 mesh sieve (preferred 80-85 mesh sieve), get the Chinese medicine composition medicinal powder.
The preparation method of described tablet is: claim 6 gained Chinese medicine composition medicinal powder according to 0.2-0.3g/ sheet (preferred 0.25g/ sheet) metering, is pressed into circular or other forms of lamellar dosage form according to the preparation for processing of tablet.
The preparation method of described tablet is: claim 6 gained Chinese medicine composition medicinal powder according to 0.2-0.3g/ grain (preferred 0.25g/ grain) metering, is processed into the capsule shape dosage form according to the preparation for processing of capsule.
The present invention also provides the application of described Chinese medicine composition when preparation treatment myocardial infarction, myocardial necrosis, anginal medicine.
The pharmacology of the used main raw material of Chinese medicine of the present invention is as follows:
Concha Margaritifera: nature and flavor: salty, cold.Gui Jing: return liver, heart channel.Effect: suppressing the hyperactive liver and subsiding YANG, arresting convulsion makes eye bright.Cure mainly: it is dizzy to be used for headache. irritated insomnia, liver-heat conjunctival congestion, deficiency of the liver blurred vision." Chinese medicine voluminous dictionary ": this thing (Concha Margaritifera) is double goes into the heart, liver two warps, with Concha Haliotidis but go into the Liver Channel person is different, thus relate to the mind patient, this.
Lignum Aquilariae Resinatum: nature and flavor: hot, bitter, tepor.Gui Jing: return spleen, stomach, kidney channel.Effect: promoting the circulation of QI to relieve pain, warming middle-JIAO to arrest vomiting, helping inspiration to relieve asthma.Cure mainly: be used for the vexed pain of breast abdominal distention, gastrofrigid vomiting singultus, the QI rising in reverse order of suffering from a deficiency of the kidney dyspnea with rapid respiration.
Rhizoma Polygoni Cuspidati: nature and flavor: little hardship is slightly cold.Gui Jing: return liver, gallbladder, lung meridian.Effect: expelling wind and removing dampness, dissipating blood stasis analgesic therapy, relieving cough and resolving phlegm.Cure mainly: be used for arthralgia, jaundice due to damp-heat, amenorrhea ， mass in the abdomen, burn due to hot liquid or fire, injury from falling down, carbuncle sore tumefacting virus, cough with copious phlegm.
Radix Platycodonis: nature and flavor: bitter, hot, flat.Gui Jing: return lung meridian.Effect: lung qi dispersing, sore-throat relieving eliminates the phlegm, evacuation of pus.Cure mainly: be used for cough with copious phlegm, uncomfortable in chest not smooth, pharyngalgia, hoarseness, lung abscess vomiting pus, skin infection difficulty in discharging of pus.
Sanguis Draxonis: nature and flavor: sweet, salty, flat.Gui Jing: GUIXIN, Liver Channel.Effect: removing blood stasis and relieving pain, hemostasia and promoting granulation.Cure mainly: be used for falling to pounce on losing ecchymoma due to internal injury; Continuous bleeding due to traumatic injury.
Colla Corii Asini: nature and flavor: sweet, flat.Gui Jing: return lung, liver, kidney channel.Effect: the YIN nourishing of enriching blood, moisturize hemostasis.Cure mainly: be used for blood deficiency and yellow complexion, dizzy cardiopalmus, the flesh flaccidity is unable, dysphoria and insomnia, stirring-up of pathogenic wind in the interior resulting from deficiency, xeropulmonary cough, chronic cough spitting of blood, haematemesis hematuria, the metrorrhagia of having blood in stool, vaginal bleeding during pregnancy.
Rhizoma Polygonati Odorati: nature and flavor: sweet, be slightly cold.Gui Jing: attach to the lung and stomach meridians.Effect: nourishing YIN to relieve dryness, promoting the production of body fluid to quench thirst.Cure mainly: be used for the lung stomach-Yin and hinder, cough caused by dryness-heat is swallowed in thirsty, and interior-heat is quenched one's thirst.
Radix Panacis Quinquefolii: sweet, the little hardship of property, cold.GUIXIN, lung, kidney channel.Effect with boosting qi and nourishing yin, clearing away heat and promoting production of body fluid.It is thanks to cloudy to be used for the deficiency of vital energy, interior-heat, and cough with asthma expectorant blood, deficiency-heat is tired tired, quenches one's thirst dryness of the mouth and throat.Radix Panacis Quinquefolii has the effect of resisting fatigue, antioxidation, anti-stress, anticoagulant, reduction blood coagulation, in addition, diabetics is regulated in addition the effect of blood glucose.
The Radix Astragali: property is sweet, tepor.Return lung, spleen, liver, kidney channel.There are benefiting QI for strengthening the superficies, arresting sweating to take off, hold in the palm the effect of skin ulcer granulation promoting, inducing diuresis to remove edema admittedly.It is weak generally to be used for the treatment of the deficiency of vital energy, sinking of QI of middle-JIAO, and the chronic diarrhea proctoptosis, the metrorrhagia of having blood in stool, the exterior deficiency spontaneous perspiration, carbuncle is difficult bursts, and burst for a long time and do not hold back, blood deficiency and yellow complexion, interior-heat is quenched one's thirst, chronic nephritis, albuminuria, diabetes etc.
Stigma Croci: nature and flavor: sweet, flat.Gui Jing: GUIXIN, Liver Channel.Effect: blood circulation promoting and blood stasis dispelling, removing pathogenic heat from blood and toxic substance from the body, resolving stagnation for tranquilization.Cure mainly: be used for amenorrhea and mass in the abdomen, postpartum stagnation, maculae caused by violent heat pathogen, melancholy painful abdominal mass is vexed, and palpitation with fear is gone mad.
Radix Salviae Miltiorrhizae: nature and flavor hardship, cold nature.The energy blood circulation promoting and blood stasis dispelling, removing heat from blood is calmed the nerves.Go into the heart, spleen two warps.According to " book on Chinese herbal medicine is looked for the truth ": Radix Salviae Miltiorrhizae has the effect into the percardium removing blood stasis with potent drugs.Modern medicine study confirms that its energy coronary artery dilator increases coronary flow, improves myocardial ischemia, infraction and cardiac function, regulates the rhythm of the heart, and can expand peripheral blood vessel, microcirculation improvement; Can improve body's hypoxia tolerance; Anticoagulation is arranged, promote fibrinolytic, suppress platelet aggregation, suppress thrombotic effect; The energy blood fat reducing suppresses coronary atherosclerosis and forms; Can shorten the convalescent period of erythrocyte and hematochrome, Reticulocyte is increased, can promote the reparation of tissue, accelerate the healing of fracture; There is nervus centralis that inhibitory action is arranged; Antitumor action is arranged; Energy enhancing human body immunity function; The energy blood sugar lowering; Various bacteria such as tubercule bacillus there is inhibitory action.
Radix Ophiopogonis: nature and flavor: sweet, little hardship is slightly cold.Gui Jing: GUIXIN, lung, stomach warp.Effect: YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire.Cure mainly: be used for dryness of the lung dry cough.The chronic consumptive disease cough, Tianjin wound is thirsty, vexed insomnia, interior-heat is quenched one's thirst, the dryness of the intestine constipation; Pharyngeal diphtheria.
Fructus Trichosanthis (son): cold in nature, sweet in the mouth, little hardship.Return lung, stomach, large intestine channel.Clearing away heat and eliminating phlegm, relieving stuffiness of the chest by dispersing aggregation of pathogens is moisturized laxation.Be used for the cough due to lung-heat, the turbid Huang of expectorant is thick, obstruction of qi in the chest and cardialgia, and the blocked-up chest feeling of fullness, acute mastitis, lung abscess, acute appendicitis swells and ache, constipation.Modern medicine and pharmacology studies have shown that: Fructus Trichosanthis has expansion heart arteria coronaria, increases the coronary flow effect; Acute myocardial ischemia there is significant protective effect.
Radix Curcumae: property suffering, hardship, cold.Return liver, the heart, lung meridian.But regulating qi to disperse stagnation, heart fire-clearing upset-relieving, promoting the function of the gallbladder to alleviate jaundice.The general amenorrhea dysmenorrhea that is used for, chest and abdomen swelling and pain, twinge, the calentura coma, epilepsy is gone mad, the jaundice dark coloured urine.
Lignum Dalbergiae Odoriferae: property suffering, temperature.Return liver, spleen channel.Has promoting flow of QI and blood, pain relieving, hemostasia effect.General epigastric pain, hypochondriac pain due to stagnation of liverQI, thoracic obstruction twinge, injury from falling down, the traumatic hemorrhage of being used for.
Fructus Hordei Germinatus nature and flavor: sweet, flat.Gui Jing: return spleen, stomach warp.Effect: spleen benefiting and stimulating the appetite, move back newborn relieving distension.Cure mainly: be used for food stagnation and do not disappear, women's ablactation, Fructus Hordei Germinatus (parched to brown) relieving dyspepsia.Be used for food stagnation and do not disappear abdominal distention.
Moschus (preferred natural Moschus): nature and flavor: suffering, temperature.Gui Jing: GUIXIN, spleen channel.Effect: the refreshment of having one's ideas straightened out, promoting blood circulation to restore menstrual flow, reducing swelling and alleviating pain.Cure mainly: be used for the calentura coma, the apoplexy syncope due to accumulation of phlegm, stagnation of QI sudden syncope, the attacked by pestiferous factors stupor, amenorrhea ， mass in the abdomen, the difficult labour stillborn fetus, trusted subordinate's sudden pain, the carbuncle scrofula, laryngopharynx swelling and pain falls and pounces on the pain of injury, the arthralgia pain numbness.
Chinese medicine composition prescription science provided by the invention, the preparation method of various dosage forms is simple, the products obtained therefrom taking convenience, is easy to carry.In addition, excellent results of the present invention also shows:
1,Selected materials is all the Chinese medicine material, and is without any side effects;
2,This prescription meets Chinese medicine principle and cardiac's body and mind characteristics fully, under the prerequisite of general principle, can different prescriptions be arranged according to different crowd, the function difference.
3,The medicine source is easy to get, and medical material is with low cost, can relieve patient ' s burden.
The specific embodiment
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
Embodiment 1The Chinese medicine composition for the treatment of coronary heart disease is prepared from by following bulk drugs: Radix Curcumae 6g, Fructus Hordei Germinatus 20 g, Lignum Dalbergiae Odoriferae 2 g, Radix Ophiopogonis 6 g, Concha Margaritifera 12 g, Lignum Aquilariae Resinatum 2 g, Rhizoma Polygoni Cuspidati 9 g, Radix Platycodonis 3 g, Sanguis Draxonis 2 g, Colla Corii Asini 6 g, Rhizoma Polygonati Odorati 5 g, Radix Panacis Quinquefolii 2 g, the Radix Astragali 20 g, Stigma Croci 2 g, Radix Salviae Miltiorrhizae 20 g, Fructus Trichosanthis 20 g, Moschus 0.03 g.
The preparation method of the Chinese medicine composition water preparation of above-mentioned treatment coronary heart disease:
(1) Radix Curcumae, Fructus Hordei Germinatus, Lignum Dalbergiae Odoriferae, Radix Ophiopogonis, Concha Margaritifera, Lignum Aquilariae Resinatum, Rhizoma Polygoni Cuspidati, Radix Platycodonis, Sanguis Draxonis, Colla Corii Asini, Rhizoma Polygonati Odorati, Radix Panacis Quinquefolii, the Radix Astragali, Stigma Croci, Radix Salviae Miltiorrhizae and Fructus Trichosanthis are pulverized, crossed 140 mesh sieves, get fine powder;
(2) with step (1) gained fine powder mix homogeneously, place in the penetrating bag, be 40 ℃ cold water immersion 8 hours with temperature, water consumption is 4 times of described fine powder weight;
(3) be heated to boiling, continue to take out penetrating bag after 1.2 hours, gained liquid gets concentrated solution through being concentrated into the 1/2-1/3 of original volume;
(4) will add in the concentrated solution of step (3) gained after the Moschus grinding, sterile packaged namely gets the Chinese medicine composition water preparation.
The instructions of taking of water preparation of the present invention: water preparation is 7 days courses for the treatment of, takes every day twice (warm), each 350m1-500m1.
Embodiment 2The Chinese medicine composition for the treatment of coronary heart disease is prepared from by following bulk drugs: Radix Curcumae 15g, Fructus Hordei Germinatus 45 g, Lignum Dalbergiae Odoriferae 6 g, Radix Ophiopogonis 15 g, Concha Margaritifera 18 g, Lignum Aquilariae Resinatum 8 g, Rhizoma Polygoni Cuspidati 25 g, Radix Platycodonis 9 g, Sanguis Draxonis 6 g, Colla Corii Asini 12 g, Rhizoma Polygonati Odorati 12 g, Radix Panacis Quinquefolii 6 g, the Radix Astragali 45 g, Stigma Croci 6 g, Radix Salviae Miltiorrhizae 45 g, Fructus Trichosanthis 45 g, Moschus 0.1 g.
The preparation method of the Chinese medicine composition medicinal powder for the treatment of coronary heart disease is: each crude drug was pulverized 100 mesh sieves, get the Chinese medicine composition medicinal powder, and divided 0.4g/ bag with powder.Adopt every day 2-3 time, each one bag, use warm boiled water, 7 days courses for the treatment of.
Model case: xxx, the age: 46 years old; Sex: women; Main suit: intermittent chest pain 3 months; History of present illness: no obvious inducement chest pain appearred in the patient before 6 hours, for vexed pain behind the breastbone, be persistence, the radiation of companion's back part, and no abdominal distention does not have stomachache, no nausea and vomiting, no fear of cold heating, no cough and expectoration.Discuss: the blood supply of electrocardio diagram coronary artery is obviously not enough, and through checking the basic chest pain that other reasons causes of getting rid of, the chest pain diagnosis is clear and definite due to the coronary heart disease.
Take the Chinese medicine composition medicinal powder of present embodiment gained treatment coronary heart disease, each one bag, every day 2 times, warm boiled water, 7 days courses for the treatment of.Took 21 days, chest pain obviously alleviates, and confusingly in the heart also alleviates, and the amount of receiving increases, spirit can, took 1 month, symptom is eliminated, the peace of sleeping night, vexed removing, strength increases, receive food can, the recovery from illness of patient's self-induction any discomfort do not appear, in the clothes 2 months of continuing when the patient takes.
Embodiment 3The Chinese medicine composition for the treatment of coronary heart disease is prepared from by following bulk drugs: Radix Curcumae 9g, Fructus Hordei Germinatus 25 g, Lignum Dalbergiae Odoriferae 3 g, Radix Ophiopogonis 9 g, Concha Margaritifera 14 g, Lignum Aquilariae Resinatum 3 g, Rhizoma Polygoni Cuspidati 12 g, Radix Platycodonis 4 g, Sanguis Draxonis 3 g, Colla Corii Asini 8 g, Rhizoma Polygonati Odorati 6 g, Radix Panacis Quinquefolii 3 g, the Radix Astragali 25 g, Stigma Croci 3 g, Radix Salviae Miltiorrhizae 25 g, Fructus Trichosanthis 25 g, Moschus 0.05 g.
The preparation method of the Chinese medicine composition tablet for the treatment of coronary heart disease is: each crude drug was pulverized 60 mesh sieves, get the Chinese medicine composition medicinal powder, gained Chinese medicine composition medicinal powder according to 0.25g/ sheet metering, is pressed into circular or other forms of lamellar dosage form according to the preparation for processing of tablet.Tablet adopts every day twice, and each 2-4 sheet is used warm boiled water, 7 days courses for the treatment of.
Model case: xxx, male, 56 years old.Precordial dull pain was had a surplus in 2 years, and every day, the pain outbreak was 2-5 time, and containing nitroglycerin could alleviate.Have uncomfortable in chest, be afraid of cold, cardiopalmus, extremities being not warm is warm, fatigue and weak, the lower limb soreness of waist that swells, diseases such as chest pain radiating to the back.Electrocardio diagram coronary insufficiency.B ultrasonic shows the merging ventricular aneurysm.Deep-slow pulse, white and thin fur.
Take the Chinese medicine composition tablet of present embodiment gained treatment coronary heart disease, adopt every day twice, each 4, use warm boiled water, 7 days courses for the treatment of.Took 21 days, precordialgia obviously alleviates, and fatigue and weak also alleviates, and the amount of receiving increases, spirit can, took 1 month, the blood supply of electrocardio diagram coronary artery obviously improves, the clothes 4 months of continuing, patient's recovery from illness.
Embodiment 4The Chinese medicine composition for the treatment of coronary heart disease is prepared from by following bulk drugs: Radix Curcumae 12g, Fructus Hordei Germinatus 40 g, Lignum Dalbergiae Odoriferae 5 g, Radix Ophiopogonis 12 g, Concha Margaritifera 16 g, Lignum Aquilariae Resinatum 6 g, Rhizoma Polygoni Cuspidati 20 g, Radix Platycodonis 6 g, Sanguis Draxonis 5 g, Colla Corii Asini 10 g, Rhizoma Polygonati Odorati 10 g, Radix Panacis Quinquefolii 5 g, the Radix Astragali 40 g, Stigma Croci 5 g, Radix Salviae Miltiorrhizae 40 g, Fructus Trichosanthis 40 g, Moschus 0.08 g.
The preparation method of the Chinese medicinal composition capsules agent for the treatment of coronary heart disease is: each crude drug was pulverized 80 mesh sieves, get the Chinese medicine composition medicinal powder, gained Chinese medicine composition medicinal powder according to 0.25g/ grain metering, is processed into the capsule shape dosage form according to the preparation for processing of capsule.
Model case: xxx, 60 years old, the man, more violent and angina pectoris frequently appearred one day, the angina pectoris persistent period is longer, and inducement is not obvious, takes nitroglycerin, but weak curative effect, during angina pectoris attacks with feel sick, vomiting, profuse sweating, bradycardia, acute cardiac insufficiency, severe arrhythmia.
Take the Chinese medicinal composition capsules agent of present embodiment gained treatment coronary heart disease, adopt every day twice, each 4, use warm boiled water, 7 days courses for the treatment of.Took 21 days, angina pectoris obviously alleviates, and feels sick, symptoms of emesis disappears, and the amount of receiving increases, spirit can, took 1 month, the blood supply of electrocardio diagram coronary artery obviously improves, the clothes 3 months of continuing, patient's recovery from illness.
Embodiment 5The Chinese medicine composition for the treatment of coronary heart disease is prepared from by following bulk drugs: Radix Curcumae 10g, Fructus Hordei Germinatus 30 g, Lignum Dalbergiae Odoriferae 4 g, Radix Ophiopogonis 10 g, Concha Margaritifera 15 g, Lignum Aquilariae Resinatum 4 g, Rhizoma Polygoni Cuspidati 16 g, Radix Platycodonis 5 g, Sanguis Draxonis 4 g, Colla Corii Asini 9 g, Rhizoma Polygonati Odorati 8 g, Radix Panacis Quinquefolii 4 g, the Radix Astragali 35 g, Stigma Croci 4 g, Radix Salviae Miltiorrhizae 35 g, Fructus Trichosanthis 35 g, Moschus 0.06 g.
The preparation method of the Chinese medicine composition water preparation for the treatment of coronary heart disease is:
(1) Radix Curcumae, Fructus Hordei Germinatus, Lignum Dalbergiae Odoriferae, Radix Ophiopogonis, Concha Margaritifera, Lignum Aquilariae Resinatum, Rhizoma Polygoni Cuspidati, Radix Platycodonis, Sanguis Draxonis, Colla Corii Asini, Rhizoma Polygonati Odorati, Radix Panacis Quinquefolii, the Radix Astragali, Stigma Croci, Radix Salviae Miltiorrhizae and Fructus Trichosanthis are pulverized, crossed 130 mesh sieves, get fine powder;
(2) with step (1) gained fine powder mix homogeneously, place in the penetrating bag, be 30 ℃ cold water immersion 7 hours with temperature, water consumption is 3.5 times of described fine powder weight;
(3) be heated to boiling, continue to take out penetrating bag after 1.0 hours, gained liquid gets concentrated solution through being concentrated into the 1/2-1/3 of original volume;
(4) will add in the concentrated solution of step (3) gained after the Moschus grinding, sterile packaged namely gets the Chinese medicine composition water preparation.
Test example 1The clinical practice of the Chinese medicine composition water preparation of embodiment 5 gained treatments coronary heart disease: in June, 2008-2011 year December, screen 120 routine patients in 4 hospitals, women's 58 examples wherein, male's 62 examples, oldest 72 years old, minimal ages 38 years old, 55.2 years old mean age.In 2 weeks before the test, this crowd is observed continuously record symptom and variation, be divided into two groups at random, experimental group and matched group, experimental group are taken embodiment 5 products obtained therefroms, and matched group is taken other medicine (conventional medicines such as metoprolol, lignocaine, norepinephrine).Using method is: take every day twice (warm), each 350m1-500m1(looks concrete condition and adjusts to some extent), 7 days courses for the treatment of.Curative effect situation criterion: cure: take course for the treatment of of this product, the blood supply of electrocardio diagram coronary artery obviously improves, and malaise symptoms disappears, and energy and muscle power obviously strengthen; Effectively: take course for the treatment of of this product, electrocardio illustrates chronic coronary artery blood supply to be improved, and malaise symptoms alleviates or part disappears, and energy and muscle power strengthen; Invalid: as to take course for the treatment of of this product, malaise symptoms no change.The result is as shown in table 1.
Table 1: take embodiment 5 product 38-72 year patients with coronary heart disease therapeutic outcome
  |
Experimental group | Matched group |
| The example number | 100 | 20 |
| Male's example number | 52 | 10 |
| Women's example number | 48 | 10 |
| Age (year) | 38-72 | 38-72 |
| Clinical cure example number | 72 | 5 |
| Effective routine number | 27 | 11 |
| Invalid routine number | 1 | 4 |
| Total effective rate | 99% | 80% |
Therapeutic effect: cure 72 examples (72%), effective 27 examples (27%), invalid 1 example (1%), total effective rate 99%.Effect obviously is better than matched group.
Self-induction symptom and physical change of spirit thereof are as shown in table 2 during taking.
Table 2:
The present invention selects Radix Panacis Quinquefolii, Fructus Trichosanthis, Radix Curcumae, Fructus Hordei Germinatus, Lignum Dalbergiae Odoriferae etc. to carry out compatibility, makes to produce synergism behind these drug regimens, can more effectively treat coronary heart disease.Radix Salviae Miltiorrhizae, Radix Curcumae, Lignum Dalbergiae Odoriferae, Stigma Croci master are at blood circulation promoting and blood stasis dispelling, removing obstruction in the collateral to relieve pain in the side; Radix Panacis Quinquefolii, the Radix Astragali, Radix Ophiopogonis Replenishing QI and nourishing YIN, hold up this training unit; Fructus Trichosanthis a surname numbness the chest stuffiness relieving; Moschus is warded off and is dirtyly had one's ideas straightened out.Concha Margaritifera, Lignum Aquilariae Resinatum, Rhizoma Polygoni Cuspidati, Radix Platycodonis, Sanguis Draxonis, Rhizoma Polygonati Odorati are used for the vexed pain of breast abdominal distention, expelling wind and removing dampness, dissipating blood stasis analgesic therapy, nourishing YIN to relieve dryness; The Colla Corii Asini nourishing blood YIN nourishing.All medicines share, and invigorate blood circulation and can yin nourishing, and blood stasis dispelling and just not hindering is had one's ideas straightened out and the QI invigorating of holding concurrently, so can obtain excellent curative.Took 10 days, feeling more than 53% takes a turn for the better to some extent, and malaise symptoms improves; Took 20 days, feeling more than 72% takes a turn for the better to some extent, and malaise symptoms improves or disappears, and spirit, muscle power strengthen; Took 30 days, feeling more than 97% takes a turn for the better to some extent, and malaise symptoms improves or disappears, and spirit, muscle power strengthen, and the blood supply of electrocardio diagram coronary artery obviously improves the recovery from illness of part patient's self-induction.Take in the experimental group more than 30 days, effective percentage can reach 93%, and matched group only is 76%.
The application's prescription is the distinguished veteran doctors of TCM proved recipe, and has passed through Liaocheng University, Liaocheng City hospital of traditional Chinese hospital experts and scholars' demonstration, has industrialization application prospect.The present inventor is the employee of the Shandong institute of political science and law (speaker's innovation and creation), and finishing of this invention has benefited from Shandong Province's 12 planning key discipline---supports of Law of Economy subject fund.
Should be pointed out that the specific embodiment is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, and a lot of distortion can also be arranged.Those of ordinary skill in the art, with the present invention clear and definite disclosed or according to undoubted the obtaining of the written description of file, all should think the claimed scope of this patent.
Claims (5)
1. the Chinese medicine composition tablet for the treatment of coronary heart disease is characterized in that, is prepared from by following bulk drugs, is weight portion: Radix Curcumae 6-15, Fructus Hordei Germinatus 20-45, Lignum Dalbergiae Odoriferae 2-6, Radix Ophiopogonis 6-15, Concha Margaritifera 12-18, Lignum Aquilariae Resinatum 2-8, Rhizoma Polygoni Cuspidati 9-25, Radix Platycodonis 3-9, Sanguis Draxonis 2-6, Colla Corii Asini 6-12, Rhizoma Polygonati Odorati 5-12, Radix Panacis Quinquefolii 2-6, Radix Astragali 20-45, Stigma Croci 2-6, Radix Salviae Miltiorrhizae 20-45, Fructus Trichosanthis 20-45, Moschus 0.03-0.1.
2. Chinese medicine composition tablet as claimed in claim 1 is characterized in that, Radix Curcumae 9-12, Fructus Hordei Germinatus 25-40, Lignum Dalbergiae Odoriferae 3-5, Radix Ophiopogonis 9-12, Concha Margaritifera 14-16, Lignum Aquilariae Resinatum 3-6, Rhizoma Polygoni Cuspidati 12-20, Radix Platycodonis 4-6, Sanguis Draxonis 3-5, Colla Corii Asini 8-10, Rhizoma Polygonati Odorati 6-10, Radix Panacis Quinquefolii 3-5, Radix Astragali 25-40, Stigma Croci 3-5, Radix Salviae Miltiorrhizae 25-40, Fructus Trichosanthis 25-40, Moschus 0.05-0.08.
3. Chinese medicine composition tablet as claimed in claim 1 is characterized in that, Radix Curcumae 10, Fructus Hordei Germinatus 30, Lignum Dalbergiae Odoriferae 4, Radix Ophiopogonis 10, Concha Margaritifera 15, Lignum Aquilariae Resinatum 4, Rhizoma Polygoni Cuspidati 16, Radix Platycodonis 5, Sanguis Draxonis 4, Colla Corii Asini 9, Rhizoma Polygonati Odorati 8, Radix Panacis Quinquefolii 4, the Radix Astragali 35, Stigma Croci 4, Radix Salviae Miltiorrhizae 35, Fructus Trichosanthis 35, Moschus 0.06.
4. as the preparation method of the arbitrary described Chinese medicine composition tablet of claim 1-3, it is characterized in that, each crude drug was pulverized 60-100 mesh sieve (preferred 80-85 mesh sieve), get the Chinese medicine composition medicinal powder; Gained Chinese medicine composition medicinal powder according to 0.2-0.3g/ sheet (preferred 0.25g/ sheet) metering, is pressed into circular or other forms of lamellar dosage form according to the preparation for processing of tablet.
5. as the application of the arbitrary described Chinese medicine composition tablet of claim 1-3 when coronary heart disease, myocardial necrosis, anginal medicine are treated in preparation.
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| 徐江雁等: "国家级名老中医治疗冠心病经验 ", 《中医研究》 * |
| 徐江雁等: "国家级名老中医治疗冠心病经验", 《中医研究》, vol. 23, no. 04, 30 April 2010 (2010-04-30), pages 54 - 59 * |
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