CN104784673B - A kind of Chinese traditional medicine navel for infantile diarrhea pastes - Google Patents
A kind of Chinese traditional medicine navel for infantile diarrhea pastes Download PDFInfo
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Abstract
The invention belongs to the field of Chinese medicines, be specifically related to a kind of Chinese traditional medicine navel for infantile diarrhea and paste.This Chinese traditional medicine navel pastes and is made up of following medicinal raw material: Radix Puerariae, Radix Glycyrrhizae, Fructus Aurantii Immaturus, Radix Bupleuri, the Radix Paeoniae Alba, Rhizoma Coptidis, Massa Medicata Fermentata, burnt short, bristly hair or beard, Rhizoma Zingiberis Preparatum, Fructus Evodiae, Flos Caryophylli, Cortex Cinnamomi, the Radix Aucklandiae, Poria, Caulis Polygoni Multiflori, Herba Lycopi.The therapy for antidiarrheal and antidiarrheal that the present invention breaks traditions, with multi-medicament, improves digestive function, the metabolism of regulation and control water liquid, correct equilibrium between yin and yang, remove gastrointestinal smooth muscular spasm, thus antidiarrheal pain relieving, for the treatment of infantile diarrhea, good effect, cure rate is high, has no side effect, easy to use.
Description
Technical field
The invention belongs to the field of Chinese medicines, be specifically related to a kind of Chinese traditional medicine navel for infantile diarrhea and paste.
Background technology
Diarrhoea be one group by many cause of diseases, multifactor cause increase with times of defecation the digestive tract syndrome changing into feature with stool, China belong to common frdquently encountered disease.Belong to Chinese medicine " to have loose bowels " category, if intemperance of taking food, cold temperature is uncomfortable, so that taste are injured, then water be instead wet, and paddy be anti-stagnant, and the gas of elite can not defeatedization, and even conjunction dirt decline, and work of having loose bowels.The reason that visible infantile diarrhea occurs, with being invaded by exogenous pathogen, hinder in diet, weakness of the spleen and stomach be common.
Infant great majority are babies of less than 2 years old, and the baby of the 6-11 month is particularly occurred frequently.Clinical symptoms shows as soft stools more, just secondaryly increases, and yellow green, water sample or egg soup sample, often with vomiting, heating, abdominal distention etc.Suffer from diarrhoea very large to the harm of people, diarrhoea can cause malnutrition, vitamin deficiency, and anemia lowers the resistance of the body, and during diarrhoea, health not only loses large quantity of moisture and nutrient substance, also can lose a large amount of electrolyte.If can not treat timely and effectively, mortality rate is also very high.
At present, some antibacterials that treatment is suffered from diarrhoea also are not suitable for children's, Antibiogics usage is improper easily causes children's's comparatively significantly untoward reaction, thus the health of children's is impacted, infant the intestines and stomach is more weak, and oral drug easily stimulates infant the intestines and stomach inwall, damage, and children's has the advantages that not easily submit to restraint, oral medicine is taken more difficult for infant, therefore present some oral formulations be not suitable for child and take on the market.
Umbilicus, cave name Shenque is the passage obtaining nutrition before fetal birth from parent, " premier's human body is all through hundred arteries and veins, the contact vital organs of the human body, extremity bones of the body collectively, face nine orifices, skin and flesh fascia ".Namely the place of spirited ascending, descending, exiting and entering, change growth and decline, belongs to an important acupuncture point of conception vessel, can play the effect regulating each internal organs physiological activity.Modern medicine is thought, umbilical part is easier to penetrate than other transdermal administration positions, and drug absorption is fast, and bioavailability is high, and the efficacy of a drug can be gone directly disease institute, can be used as the desirable medicine-feeding part of transdermal administration and slow release long-acting.
Summary of the invention
Inventor has Chinese traditional treatment experience for many years, be apt to examine pathogenesis, bright pathology, brief points purport, in conjunction with the feature of infantile diarrhea, there is provided a kind of Chinese traditional medicine navel for infantile diarrhea to paste, this Chinese traditional medicine navel pastes has good effect for infantile diarrhea, and cure rate is high, have no side effect, be applicable to child to use, cheap, the feature that healing time is short.Alleviate the misery of infant, for the household of infant and infant alleviates burden and economic pressures at heart.
For achieving the above object, the present invention adopts following technical scheme:
A kind of Chinese traditional medicine navel for infantile diarrhea pastes, and it is characterized in that it is made up of following medicinal raw material: Radix Puerariae, Radix Glycyrrhizae, Fructus Aurantii Immaturus, Radix Bupleuri, the Radix Paeoniae Alba, Rhizoma Coptidis, Massa Medicata Fermentata, burnt short, bristly hair or beard, Rhizoma Zingiberis Preparatum, Fructus Evodiae, Flos Caryophylli, Cortex Cinnamomi, the Radix Aucklandiae, Poria, Caulis Polygoni Multiflori, Herba Lycopi.
Medicinal raw material consumption of the present invention is groped to sum up to draw through inventor in a large number, and each raw material dosage is for all to have good curative effect in following weight parts scope: Radix Puerariae 11-16 part, Radix Glycyrrhizae 9-15 part, Fructus Aurantii Immaturus 9-15 part, Radix Bupleuri 10-16 part, Radix Paeoniae Alba 11-15 part, Rhizoma Coptidis 3-8 part, Massa Medicata Fermentata 8-13 part, burnt short, bristly hair or beard 8-13 part, Rhizoma Zingiberis Preparatum 9-15 part, Fructus Evodiae 7-12 part, Flos Caryophylli 8-13 part, Cortex Cinnamomi 8-11 part, Radix Aucklandiae 9-13 part, Poria 11-16 part, Caulis Polygoni Multiflori 10-15 part, Herba Lycopi 11-16 part.
Preferably one of the scheme optimized is: a kind of Chinese traditional medicine navel for infantile diarrhea pastes, and it is characterized in that it is made up of the medicinal raw material of following weight portion: Radix Puerariae 13 parts, 10 parts, Radix Glycyrrhizae, Fructus Aurantii Immaturus 12 parts, Radix Bupleuri 12 parts, the Radix Paeoniae Alba 12 parts, Rhizoma Coptidis 6 parts, Massa Medicata Fermentata 10 parts, burnt short, bristly hair or beard 10 parts, Rhizoma Zingiberis Preparatum 10 parts, Fructus Evodiae 10 parts, Flos Caryophylli 10 parts, Cortex Cinnamomi 9 parts, the Radix Aucklandiae 10 parts, 12 parts, Poria, Caulis Polygoni Multiflori 12 parts, Herba Lycopi 13 parts.
Infantile diarrhea is mainly transformation and transportation of the spleen and stomach imbalance, and the important department of lifting is disorderly, water paddy regardless of and walk large intestine, just, Fructus Aurantii Immaturus is regulated the flow of vital energy removing food stagnancy, arresting collape syndrome by astringents; The therapeutic method to keep the adverse QI flowing downwards in Massa Medicata Fermentata invigorating the spleen and regulating the stomach, tune; Burnt short, bristly hair or beard promoting digestion and invigorating the stomach, circulation of qi promoting intestinal stasis relieving, Radix Aucklandiae strengthening the spleen to promote digestion, promoting the circulation of QI to relieve pain, dampness de-swelling, 5 use invigorating the spleen and regulating the stomach, circulation of qi promoting intestinal stasis relieving, and removing food stagnancy antidiarrheal benefit is good, and Rhizoma Coptidis dispelling the damp pathogen with drugs of bitter in taste and cold in nature is with thick intestinal only profit, and Radix Paeoniae Alba yin fluid astringing promotes the production of body fluid, easing the affected liver emergency only stomachache; Rhizoma Zingiberis Preparatum, Flos Caryophylli, Cortex Cinnamomi, Fructus Evodiae dispersing cold for relieving pain, stopping nausea and vomiting by lowering the adverse flow of QI, supporing yang antidiarrheal; Radix Puerariae sending up the lucid YANG, bring down a fever and promote the production of body fluid; Poria promoting diuresis to eliminate damp pathogen, treating diarrhea by diuretics, to invigorate blood circulation row water with Herba Lycopi, Caulis Polygoni Multiflori tranquilizing by nourishing the heart, dredging collateral; Radix Bupleuri reconciling superficies and interior, Radix Glycyrrhizae invigorating the spleen and replenishing QI, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.
We break traditions for antidiarrheal and the therapy of antidiarrheal, with multi-medicament, launch an attack comprehensively, improve digestive function, the metabolism of regulation and control water liquid, correct equilibrium between yin and yang, remove gastrointestinal smooth muscular spasm, thus antidiarrheal pain relieving, to the infantile diarrhea that a variety of causes causes, as diarrhea due to improper diet, diarrhea due to cold pathogen, splenoasthenic diarrhea, Be very effective.
In medicine of the present invention, the present Research of medicinal raw material is as described below.
Radix Puerariae: sweet, pungent, cool.Return spleen, stomach warp.Function cures mainly: expelling pathogenic factors from muscles for reducing heat, promotes the production of body fluid, rash, yang invigorating antidiarrheal.For fever caused by exogenous pathogens headache, stiff nape and back, thirsty, quench one's thirst, measles without adequate eruption, hematodiarrhoea, has loose bowels; Hypertension neck pain.
Radix Glycyrrhizae: sweet, flat.GUIXIN, lung, spleen, stomach warp.Function cures mainly: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.
Fructus Aurantii Immaturus: bitter, pungent, sour, temperature.Return spleen, stomach warp.Function cures mainly: dispelling the stagnated QI removing food stagnancy, loose painful abdominal mass of reducing phlegm.Stop in stagnant, feeling of fullness distending pain, heavy after dysentery, constipation, the stagnant vapour lock thoracic obstruction of expectorant, blocked-up chest; Gastroptosis, proctoptosis, uterine prolapse.
Radix Bupleuri: bitter, is slightly cold.Return liver, gallbladder meridian.Function cures mainly: reconciling superficies and interior, soothing the liver, yang invigorating.For cold, fever, alternate attack of chill and fever, distending pain in the chest and hypochondrium, menoxenia, sub-official's prolapsus, proctoptosis.
The Radix Paeoniae Alba: bitter, sour, is slightly cold.Return liver, spleen channel.Function cures mainly: suppressing the hyperactive liver pain relieving, nourishing blood for regulating menstruation, astringing YIN to stop sweating.Dizzy for having a headache, hypochondriac pain, stomachache, limb pain twin, blood deficiency and yellow complexion, menoxenia, spontaneous perspiration, night sweat.
Rhizoma Coptidis: bitter, cold.GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel.Function cures mainly: heat clearing and damp drying, eliminating fire and detoxication.For damp and hot feeling of fullness, vomiting acid regurgitation, dysentery, jaundice, unconsciousness due to high fever, hyperactivity of heart-fire, dysphoria and insomnia, heat in blood tells nosebleed, conjunctival congestion, and toothache, quenches one's thirst, carbuncle furuncle; External treatment eczema, eczema, auditory meatus is suppurated.
Massa Medicata Fermentata: sweet, acrid, warm.Enter spleen, stomach warp.Function cures mainly: invigorating the spleen and regulating the stomach, helps digestion in adjusting.Control retention of food and drink, feeling of stuffiness in chest abdominal distention, vomiting dysentery, postnatal blood stasis is suffered from abdominal pain, and children's's enlarged abdomen heavily fortified point is long-pending.
Burnt short, bristly hair or beard: get clean Fructus Crataegi slice and put in pot, fry to surface coke brown, inner yellowish-brown.This product surface coke brown, inner yellowish-brown.Gas delicate fragrance, sour in the mouth, micro-puckery.Promoting digestion and invigorating the stomach, circulation of qi promoting dissipating blood stasis.For meat stagnation, gastral cavilty distension, dysentery is suffered from abdominal pain, blood stasis amenorrhea, postpartum stagnation, trusted subordinate's twinge, hernia pain; Hyperlipemia.The effect of Fructus Crataegi (parched to brown) dyspepsia and intestinal stasis relieving strengthens.For meat stagnation, dysentery is not well.
Rhizoma Zingiberis Preparatum: pungent, hot.Return spleen, stomach, kidney, the heart, lung meridian.Function cures mainly: warming spleen and stomach for dispelling cold, warming the meridian for stopping bleeding.For Deficiency and coldness of spleen and stomach, stomachache is vomited and diarrhoea, and tell nosebleed metrorrhagia, yang deficiency is lost blood.
Fructus Evodiae: pungent, bitter, heat; Slightly poisonous.Return liver, spleen, stomach, kidney channel.Function cures mainly: dispersing cold for relieving pain, stopping nausea and vomiting by lowering the adverse flow of QI, supporing yang antidiarrheal.For headache due to JUE YIN disorder, colic of cold type is suffered from abdominal pain, the disturbance of lower legs due to pathogenic cold and dampness, abdominal pain during menstruation, abdominal distention, vomiting acid regurgitation, Diarrhoea, external treatment aphtha; Hypertension.
Flos Caryophylli: pungent, temperature.Return spleen, stomach, lung, kidney channel.Function cures mainly; Warming middle-JIAO to send down the adverse QI, reinforcing the kidney and supporting YANG.For Deficiency and coldness of spleen and stomach, singultus is vomitted, lack of appetite and vomiting, trusted subordinate's cold type of pain, impotence due to deficiency of the kidney.
Cortex Cinnamomi: pungent, sweet, hot greatly.Return kidney, spleen, the heart, Liver Channel.Function cures mainly: mend fire supporing yang, let the fire back to its origin, dispersing cold for relieving pain, promoting blood circulation to restore menstrual flow.For sexual impotence, cold womb, chills and pain of the waist and kness, suffers from a deficiency of the kidney and breathes heavily, dizziness due to yang deficiency, conjunctival congestion pharyngalgia, trusted subordinate's cold type of pain, and deficiency and coldness is vomited and diarrhoea, colic of cold type, renal mass, amenorrhea, dysmenorrhea.
The Radix Aucklandiae: pungent, bitter, temperature.Return spleen, stomach, large intestine, three burnt, gallbladder meridians.Function cures mainly: promoting the circulation of QI to relieve pain, strengthening the spleen to promote digestion.For breast gastral cavity distending pain, heavy after dysentery, food stagnation does not disappear, anorexia.The real intestinal antidiarrheal of Radix Aucklandiae (roasted).For stomachache of having loose bowels.
Poria: sweet, light is flat.GUIXIN, lung, spleen, kidney channel.Function cures mainly: promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming.For edema oliguria, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in loose stool, irritability, palpitation with fear insomnia.
Caulis Polygoni Multiflori: sweet, micro-hardship, property is put down.GUIXIN, Liver Channel.Function cures mainly: tranquilizing by nourishing the heart; Dispel the wind; Dredging collateral.Main insomnia; Dreaminess; Blood deficiency general pain; Numbness of the skin; Rheumatic arthralgia; Rubella pruritus.
Herba Lycopi: bitter, pungent, tepor.Return liver, spleen channel.Function cures mainly: blood circulation promoting and blood stasis dispelling, line water detumescence.For menoxenia, amenorrhea, dysmenorrhea, postnatal blood stasis is suffered from abdominal pain, edema.
Present invention also offers the preparation method that a kind of Chinese traditional medicine navel for infantile diarrhea pastes, concrete preparation process is as follows: extracting liquorice, Fructus Aurantii Immaturus, Radix Bupleuri, the Radix Paeoniae Alba, Rhizoma Zingiberis Preparatum, Poria, Caulis Polygoni Multiflori, Herba Lycopi decoct with water twice, amount of water is 5-8 times of medical material amount for the first time, decoct 2-3 hour, second time amount of water is that the 3-4 of medical material amount doubly decocts 1-2 hour, collecting decoction, filters, filtrate reduced in volume becomes dry extract, is ground into fine powder for subsequent use; Get Radix Puerariae, Rhizoma Coptidis, Massa Medicata Fermentata, burnt short, bristly hair or beard, Fructus Evodiae, Flos Caryophylli, Cortex Cinnamomi, the Radix Aucklandiae, dry, pulverizing, crosses 80 mesh sieves, medicinal powder after pulverizing fully is mixed homogeneously with dry extract, do wet suitable pasty state with rice vinegar furnishing, be laid in the annulus of sky plaster, obtain final product.
The usage and dosage that Chinese traditional medicine navel of the present invention pastes: being sticked by umbilicus in infant umbilical part, once a day, three days is a course for the treatment of.
Chinese herbs paste of the present invention is drawn materials extensively, good effect, and cure rate is high, has no side effect, easy to use, and be applicable to child and use, cheap, healing time is short, can reduce the injury of Western medicine to infant health, improves the compliance of children.While treatment infantile diarrhea, intestinal can be protected to greatest extent, integrated regulation gastrointestinal function.Moreover being conducive to Meridian Tropism of Herbal Drugs from umbilical region administration, drug effect is followed through through sick institute, reaches the object of driving away pathogenic factor, reinforcing body resistance.
Detailed description of the invention
Further describe the present invention below by way of detailed description of the invention, but the present invention is not limited only to following examples.Within the scope of the invention or not departing from content of the present invention, spirit and scope, Chinese medicine preparation of the present invention is suitably improved, replaces the identical component of effect, will become apparent to those skilled in the art that they are all deemed to be included within scope of the present invention.
Embodiment 1
Prescription: Radix Puerariae 13 parts, 10 parts, Radix Glycyrrhizae, Fructus Aurantii Immaturus 12 parts, Radix Bupleuri 12 parts, the Radix Paeoniae Alba 12 parts, Rhizoma Coptidis 6 parts, Massa Medicata Fermentata 10 parts, burnt short, bristly hair or beard 10 parts, Rhizoma Zingiberis Preparatum 10 parts, Fructus Evodiae 10 parts, Flos Caryophylli 10 parts, Cortex Cinnamomi 9 parts, the Radix Aucklandiae 10 parts, 12 parts, Poria, Caulis Polygoni Multiflori 12 parts, Herba Lycopi 13 parts.
Preparation method: extracting liquorice, Fructus Aurantii Immaturus, Radix Bupleuri, the Radix Paeoniae Alba, Rhizoma Zingiberis Preparatum, Poria, Caulis Polygoni Multiflori, Herba Lycopi decoct with water twice, amount of water is 5-8 times of medical material amount for the first time, decoct 2-3 hour, second time amount of water is that the 3-4 of medical material amount doubly decocts 1-2 hour, collecting decoction, filter, filtrate reduced in volume becomes dry extract, is ground into fine powder for subsequent use; Get Radix Puerariae, Rhizoma Coptidis, Massa Medicata Fermentata, burnt short, bristly hair or beard, Fructus Evodiae, Flos Caryophylli, Cortex Cinnamomi, the Radix Aucklandiae, dry, pulverizing, cross 80 mesh sieves, medicinal powder after pulverizing fully is mixed homogeneously with dry extract, wet suitable pasty state is done with rice vinegar furnishing, be laid in annulus that the length of side is the empty plaster of 7cm × 7cm, circle diameter is 2.5cm, and the degree of depth is 0.5cm.
Embodiment 2
Prescription: Radix Puerariae 11 parts, 9 parts, Radix Glycyrrhizae, Fructus Aurantii Immaturus 9 parts, Radix Bupleuri 10 parts, the Radix Paeoniae Alba 12 parts, Rhizoma Coptidis 5 parts, Massa Medicata Fermentata 10, burnt short, bristly hair or beard 8 parts, Rhizoma Zingiberis Preparatum 9 parts, Fructus Evodiae 12 parts, Flos Caryophylli 8 parts, Cortex Cinnamomi 8 parts, the Radix Aucklandiae 10 parts, 12 parts, Poria, Caulis Polygoni Multiflori 10 parts, Herba Lycopi 11 parts.
Preparation method: carry out with reference to embodiment 1.
Embodiment 3
Prescription: Radix Puerariae 16 parts, 12 parts, Radix Glycyrrhizae, Fructus Aurantii Immaturus 13 parts, Radix Bupleuri 16 parts, the Radix Paeoniae Alba 15 parts, Rhizoma Coptidis 7 parts, Massa Medicata Fermentata 10 parts, burnt short, bristly hair or beard 12 parts, Rhizoma Zingiberis Preparatum 15 parts, Fructus Evodiae 12 parts, Flos Caryophylli 13 parts, Cortex Cinnamomi 11 parts, the Radix Aucklandiae 13 parts, 16 parts, Poria, Caulis Polygoni Multiflori 15 parts, Herba Lycopi 16 parts.
Preparation method: carry out with reference to embodiment 1.
Embodiment 4
Prescription: Radix Puerariae 13 parts, 10 parts, Radix Glycyrrhizae, Fructus Aurantii Immaturus 12 parts, Radix Bupleuri 10 parts, the Radix Paeoniae Alba 11 parts, Rhizoma Coptidis 8 parts, Massa Medicata Fermentata 13 parts, burnt short, bristly hair or beard 12 parts, Rhizoma Zingiberis Preparatum 12 parts, Fructus Evodiae 10 parts, Flos Caryophylli 10 parts, Cortex Cinnamomi 11 parts, the Radix Aucklandiae 10 parts, 13 parts, Poria, Caulis Polygoni Multiflori 12 parts, Herba Lycopi 11 parts.
Preparation method: carry out with reference to embodiment 1.
Embodiment 5
Prescription: Radix Puerariae 16 parts, 10 parts, Radix Glycyrrhizae, Fructus Aurantii Immaturus 13 parts, Radix Bupleuri 10 parts, the Radix Paeoniae Alba 13 parts, Rhizoma Coptidis 6 parts, Massa Medicata Fermentata 10 parts, burnt short, bristly hair or beard 11 parts, Rhizoma Zingiberis Preparatum 12 parts, Fructus Evodiae 7 parts, Flos Caryophylli 8 parts, Cortex Cinnamomi 11 parts, the Radix Aucklandiae 10 parts, 15 parts, Poria, Caulis Polygoni Multiflori 10 parts, Herba Lycopi 15 parts.
Preparation method: carry out with reference to embodiment 1.
Embodiment 6
Prescription: Radix Puerariae 12 parts, 12 parts, Radix Glycyrrhizae, Fructus Aurantii Immaturus 12 parts, Radix Bupleuri 15 parts, the Radix Paeoniae Alba 13 parts, Rhizoma Coptidis 7 parts, Massa Medicata Fermentata 10 parts, burnt short, bristly hair or beard 13 parts, Rhizoma Zingiberis Preparatum 12 parts, Fructus Evodiae 10 parts, Flos Caryophylli 11 parts, Cortex Cinnamomi 10 parts, the Radix Aucklandiae 9 parts, 15 parts, Poria, Caulis Polygoni Multiflori 10 parts, Herba Lycopi 14 parts.
Preparation method: carry out with reference to embodiment 1.
Set forth the beneficial effect of medicine of the present invention further below by way of test example, these tests comprise animal toxicity test and the clinical observation test of medicine of the present invention.
Embodiment 7 Chinese traditional medicine navel of the present invention pastes the irritant experiment to skin
Experimental technique: select healthy New Zealand white rabbit 12, body weight 1.5 ~ 2.5kg, is divided into normal skin group and each 6 of skin injury group, adopts consubstantiality left and right sides self-contrast method, male and female half and half.Before test, 24h carries out depilation process to administration district, each one piece of left and right, unhairing scope 3cm × 3cm.Damaged skin group draws " well " word at agents area, to ooze out blood for degree.Often group left side depilation place lose money in a business inventive embodiments 1-3 umbilicus paste, right side be coated with tablet vinegar contrast.Application time 24h, every day 1 time, continuous 7d.After sticking end at every turn, removing test sample with warm water or nonirritant solvent cleaned medicine-feeding part.Examine coating place skin before each coating with or without erythema, edema, continue after drug withdrawal to observe 3d, carry out skin irritation evaluation by the requirement of new drug toxicity technical specification.Bark fetching Fu Zuo tissue pathology checking simultaneously.
Skin irritation is evaluated:
(1) standards of grading: erythema: without erythema 0 point; Slight erythema (visible reluctantly) 1 point; 2 points, the red class of moderate (obviously visible); Severe erythema 3 points; Aubergine erythema forms 4 points to slight eschar.Edema: without edema 0 point; Mild edema (visible reluctantly)) point; Intermediate edema (obviously swelling) 2 points; Severe edema (cutaneous protuberance 1mm, profile is clear) 3 points; Severe edema (cutaneous protuberance > lmm also has expansion) 4 points.Highest point total is worth 8 points.
(2) skin irritation intensity evaluation standard: 0-0.49 divides nonirritant; 0.50 ~ 2.99 point of slight zest; 3.00 ~ 5.99 points of moderate zests; 6.00 ~ 8.00 points of strong and stimulatings.
Result: duration of test two groups of rabbit spirit, sign are good, and appetite activity is normal; Without dead, also have no any untoward reaction; Hematological examination, biochemical investigation are showed no exception; System becomes celestial and each internal organs histopathology no abnormality seen; Restorative observation has no retardance toxic reaction, the Testing index normal value of reference people and rabbit, above result is all within normal range, two groups of more equal nonsignificances (P>0.05), show that rabbit is pasted with the umbilicus of embodiment of the present invention 1-3 for a long time and do not produce toxic reaction.
Embodiment 8 Chinese traditional medicine navel of the present invention pastes the allergic experiment to skin
Experimental technique: Cavia porcellus 40, body weight 250-330g, is divided into the umbilicus subsides group 20 of the embodiment of the present invention 1,3, and often group 10, tablet vinegar matched group 10 only reach DNFB positive controls 10, and male and female half and half, shave off skin of back.After 24h, by grouping administration, (umbilicus subsides group pastes the umbilicus subsides of embodiment 1,3 respectively, and tablet vinegar matched group and DNFB positive controls press 0.5g/cm
2administration) paste or be coated in district's sensitization of losing hair or feathers on the left of Cavia porcellus, coating is repeated once after 3h, to ensure medicament contact 6h, sensitization is repeated in 7th day and the 14th day. in last administration 14d again by grouping by medicine paste or be applied to district of losing hair or feathers on the right side of Cavia porcellus and excite, tested material is removed after 6h, observe erythema and edema situation, Continuous Observation 3d. marks by skin allergy standard.
Skin irritation is evaluated: with reference to the irritant experiment of skin
Result: experimental result display positive controls erythema and edema all clearly (erythema 3.23 points, edema 2.12 points), the umbilicus subsides group of tablet vinegar matched group and the embodiment of the present invention 1,3 then skin smooth, without erythema, without edema (being 0 point), do not show any anaphylaxis.
Embodiment 9 clinical observation is tested
1. physical data: infant is all from infant totally 242 examples that in June ,-2014 in August, 2013 goes to a doctor to my institute, wherein male 128 example, women 114 example, age 6-32 month, average 18 months, course of disease 2-30 days, clinical manifestation is that times of defecation is many, every day about 10 times, rare watery stool, yellow or yellow green, be mixed with a small amount of mucus milk lobe or indigestion food, have mild dehydration, heating, just routine examination erythrocyte, leukocyte are in 15 below, every visual field, all meet the diagnostic criteria of 7 editions " practical paidonosologies " more.Be divided into treatment group and matched group at random, often organize 121 examples, two groups of infants carry out contrast difference's not statistically significant (P > 0.05) in every respect, can carry out comparative study.
2. method: occur the existing infant of dewatering table and all give conventional fluid-supplement therapy, the infant for the treatment of group is applied Chinese traditional medicine navel prepared by the embodiment of the present invention 1 on this basis and is pasted, once a day; Matched group infant gives montmorillonite powder and treats, less than 1 years old each 1/3 bag, more than 1 years old and 1 years old each 1/2 bag, 3 times/d, associating bacillus bifidus three active bacteria capsule, 2 times/d, medicated powder warm water in capsule or warm milk can be taken after mixing it with water, treatment is 3d the course for the treatment of.
3. index of assessment of curative effect is evaluated patient according to the curative effect index of national diarrhoeal diseases control academic conference: effective: after the course for the treatment of, infant stool situation recovers normal, and clinical manifestation disappears; Effective: after the course for the treatment of, the stool situation of infant improves, and clinical manifestation improves; Invalid: after the course for the treatment of, infant does not obviously improve or occurs worsening.
4. result
After 4.1 1 courses for the treatment of, two groups of comparitive study, treatment group cures 53 examples, and take a turn for the better 55 examples, total effective rate 89.3%; Matched group cures 20 examples, and take a turn for the better 57 examples, and total effective rate 63.6%, two groups of cure rates and total effective rate compare, and difference has statistical significance (P<0.05), and treatment group curative effect is obviously better than matched group.In table 1.
After the course for the treatment of of table 1, two groups of comparitive study, example (%)
After 4.2 two courses for the treatment of, two groups of comparitive study, treatment group cures 89 examples, and take a turn for the better 29 examples, total effective rate 97.5%; Matched group cures 53 examples, and take a turn for the better 43 examples, and total effective rate 79.3%, two groups of cure rates and total effective rate compare, and difference has statistical significance (P<0.05), and treatment group curative effect is obviously better than matched group.In table 2.
After two courses for the treatment of of table 2, two groups of comparitive study, example (%)
Can find that treatment group is apparently higher than matched group by the cure rate and total effective rate that contrast two of two groups of infants treatment courses for the treatment of, illustrate thus, Chinese medicine of the present invention has good clinical effectiveness at treatment infantile diarrhea, and short treating period, effective percentage is high, is worth promoting in clinical practice.
Claims (3)
1. the Chinese traditional medicine navel for infantile diarrhea pastes, and it is characterized in that it is made up of the medicinal raw material of following weight portion: Radix Puerariae 11-16 part, Radix Glycyrrhizae 9-15 part, Fructus Aurantii Immaturus 9-15 part, Radix Bupleuri 10-16 part, Radix Paeoniae Alba 11-15 part, Rhizoma Coptidis 3-8 part, Massa Medicata Fermentata 8-13 part, burnt short, bristly hair or beard 8-13 part, Rhizoma Zingiberis Preparatum 9-15 part, Fructus Evodiae 7-12 part, Flos Caryophylli 8-13 part, Cortex Cinnamomi 8-11 part, Radix Aucklandiae 9-13 part, Poria 11-16 part, Caulis Polygoni Multiflori 10-15 part, Herba Lycopi 11-16 part.
2. Chinese traditional medicine navel as claimed in claim 1 pastes, and it is characterized in that it is made up of the medicinal raw material of following weight portion: Radix Puerariae 13 parts, 10 parts, Radix Glycyrrhizae, Fructus Aurantii Immaturus 12 parts, Radix Bupleuri 12 parts, the Radix Paeoniae Alba 12 parts, Rhizoma Coptidis 6 parts, Massa Medicata Fermentata 10 parts, burnt short, bristly hair or beard 10 parts, Rhizoma Zingiberis Preparatum 10 parts, Fructus Evodiae 10 parts, Flos Caryophylli 10 parts, Cortex Cinnamomi 9 parts, the Radix Aucklandiae 10 parts, 12 parts, Poria, Caulis Polygoni Multiflori 12 parts, Herba Lycopi 13 parts.
3. Chinese traditional medicine navel as claimed in claim 1 or 2 pastes, it is characterized in that its preparation method comprises the steps: that extracting liquorice, Fructus Aurantii Immaturus, Radix Bupleuri, the Radix Paeoniae Alba, Rhizoma Zingiberis Preparatum, Poria, Caulis Polygoni Multiflori, Herba Lycopi decoct with water twice, amount of water is 5-8 times of medical material amount for the first time, decoct 2-3 hour, second time amount of water is that the 3-4 of medical material amount doubly decocts 1-2 hour, collecting decoction, filters, filtrate reduced in volume becomes dry extract, is ground into fine powder for subsequent use; Get Radix Puerariae, Rhizoma Coptidis, Massa Medicata Fermentata, burnt short, bristly hair or beard, Fructus Evodiae, Flos Caryophylli, Cortex Cinnamomi, the Radix Aucklandiae, dry, pulverizing, crosses 80 mesh sieves, medicinal powder after pulverizing fully is mixed homogeneously with dry extract, do wet suitable pasty state with rice vinegar furnishing, be laid in the annulus of sky plaster, obtain final product.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105412508A (en) * | 2015-12-18 | 2016-03-23 | 刘乐翠 | Preparation method of navel plaster for treating diarrhea after convulsions |
| CN107773740A (en) * | 2016-08-26 | 2018-03-09 | 王维其 | A kind of warm navel patch for treating baby diarrhea |
| CN109010681A (en) * | 2018-10-22 | 2018-12-18 | 河南名锐药业有限责任公司 | A kind of health-care patch and preparation method thereof for treating baby diarrhea |
| CN109847029A (en) * | 2019-04-11 | 2019-06-07 | 关慧波 | It is a kind of for treating the application plaster of fever in children |
| CN111529672B (en) * | 2020-05-26 | 2022-03-04 | 驻马店市淘儿宁药械有限公司 | A Chinese medicinal navel patch for treating infantile diseases via navel part, and its preparation method |
| CN115845009B (en) * | 2022-08-22 | 2023-09-29 | 河南中医药大学第一附属医院 | Navel moxibustion medicinal powder for treating spleen deficiency diarrhea and application thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101274081A (en) * | 2008-04-22 | 2008-10-01 | 梁进 | Paste for reinforcing spleen and promoting digestion |
| CN102370764A (en) * | 2010-08-12 | 2012-03-14 | 潘立芝 | Traditional Chinese medicinal patch for treating infantile diarrhea caused by improper diet |
| CN103638130A (en) * | 2013-12-16 | 2014-03-19 | 河南中医学院 | Umbilical paste for treating infant diarrhea |
-
2015
- 2015-05-15 CN CN201510246978.0A patent/CN104784673B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101274081A (en) * | 2008-04-22 | 2008-10-01 | 梁进 | Paste for reinforcing spleen and promoting digestion |
| CN102370764A (en) * | 2010-08-12 | 2012-03-14 | 潘立芝 | Traditional Chinese medicinal patch for treating infantile diarrhea caused by improper diet |
| CN103638130A (en) * | 2013-12-16 | 2014-03-19 | 河南中医学院 | Umbilical paste for treating infant diarrhea |
Non-Patent Citations (1)
| Title |
|---|
| 小儿腹泻中医治疗近况;史春合等;《辽宁中医杂志》;19971118;第24卷(第11期);526-527 * |
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