CN105079586A - Traditional Chinese medicine composition for treating hypertension - Google Patents
Traditional Chinese medicine composition for treating hypertension Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine composition for treating hypertension. The traditional Chinese medicine composition is characterized by being prepared from the following active pharmaceutical ingredients in parts by weight: 5-20 parts of panax notoginseng, 1-10 parts of plantain seed, 2-20 parts of uncaria rhynchophylla, 5-20 parts of radix rehmanniae, 8-20 parts of liquorice, 8-32 parts of blighted wheat, 10-40 parts of haw, 1-15 partso f selfheal, 15-25 parts of eucommia ulmoides, 20-40 parts of dried orange peel, 1-5 parts of borneol and 1-8 parts of immature bitter orange. The blood pressure of a patient can be reduced within a short time after the traditional Chinese medicine composition is taken; the traditional Chinese medicine composition has a stable treatment effect; the blood pressure cannot return to the high level after withdrawal of the traditional Chinese medicine composition, that is, the rate of blood pressure rebound is low; the traditional Chinese medicine composition is simple in preparation method and low in cost, and has a very high social value.
Description
Technical field
The present invention relates to a kind of Chinese medicine, particularly one treats hypertensive Chinese medicine composition, belongs to pure technical field of Chinese medicines.
Background technology
Hypertension be a kind of with arteriotony rising for feature, can be troubling with systemic disease China Prevalence of Hypertension of the organ functional such as heart, brain kidney and blood vessel or organic change, between 1958-1959, Prevalence of Hypertension is 5.1%, prevalence 7.7% between 1979-1980,1991 annual loading are 11.9%, 2004 annual loading is 18.8%.China hyperpietic, more than 100,000,000, relates to several ten million families, has become the social problem that one, China is great.Artery in Patients with Hypertension pressure holding height of continuing rising, can cause whole body arteriolosclerosis, thus affects the blood supply of histoorgan, causes serious consequence and causes multiple complications.In hypertensive multiple complications, the most serious with the infringement of the heart, brain, kidney, the diseases such as such as hypertensive cerebral coronary heart disease, apoplexy and renal failure.Estimate according to WHL, to the year two thousand twenty, cardiovascular disease and apoplexy will become the primary lethal and reason that disables in the whole world, hypertension by be cause primary hidden danger that these events occur it have essential hypertension and secondary hypertension point.
Chinese medicine is thought, hypertension is the result because body imbalance between YIN and YANG produces.The deficiency of YIN is this, and yang hyperactivity is mark, and pathological changes is relevant with the five internal organs, the main heart, liver, the kidney of relating to, being designated as liver, is being kidney at this, and clinical manifestation for cardinal symptom, is damaged in front with the moon with the hepatic and renal YIN deficiency or excessive rising of liver-YANG, yang hyperactivity in rear be main feature, arrived the course of disease later stage, developed into deficiency of both YIN and YANG.Conditioning viscera function, recovering equilibrium between yin and yang, is the hypertensive basic principle of traditional Chinese medical herbal treatment.
The hypertensive method of current treatment, Western medicine, the traditional Chinese medical science, Chinese and Western combined therapy blood pressure lowering, Western medicine is relatively rapider, but once drug withdrawal blood pressure will return to original level at once, cures the symptoms, not the disease.Chinese medicine and western medicine process is slow.
Summary of the invention
For the defect of prior art, present inventor, through deep research and performing creative labour, provides that a kind of therapeutic effect is good, efficiency is high, to the hypertensive Chinese medicine composition prescription of the treatment of human non-toxic's side effect.
According to Chinese medical theory, utilize the property of medicine of Chinese medicine uniqueness, meticulously screen the Chinese medicine in affiliated field, obtain one and treat hypertensive Chinese medicine formula, formula is Radix Notoginseng, Semen Plantaginis, Ramulus Uncariae Cum Uncis, the Radix Rehmanniae, Radix Glycyrrhizae, Fructus Tritici Levis, Fructus Crataegi, Spica Prunellae, the Cortex Eucommiae, Pericarpium Citri Reticulatae, Borneolum Syntheticum, Fructus Aurantii Immaturus.
Prepare Chinese medicine composition of the present invention to be made up of following raw material medicaments, calculate with weight ratio: Radix Notoginseng 5-20 part, Semen Plantaginis 1-10 part, Ramulus Uncariae Cum Uncis 2-20 part, Radix Rehmanniae 5-20 part, Radix Glycyrrhizae 8-20 part, Fructus Tritici Levis 8-32 part, Fructus Crataegi 10-40 part, Spica Prunellae 1-15 part, Cortex Eucommiae 15-25 part, Pericarpium Citri Reticulatae 20-40 part, Borneolum Syntheticum 1-5 part, Fructus Aurantii Immaturus 1-8 part.
Carry out preferably above-mentioned Chinese medicine composition, preferred weight portion is: carry out preferably to above-mentioned Chinese medicine composition: Radix Notoginseng 10-15 part, Semen Plantaginis 5-8 part, Ramulus Uncariae Cum Uncis 8-15 part, Radix Rehmanniae 10-15 part, Radix Glycyrrhizae 12-15 part, Fructus Tritici Levis 15-25 part, Fructus Crataegi 20-30 part, Spica Prunellae 10-15 part, Cortex Eucommiae 18-22 part, Pericarpium Citri Reticulatae 25-35 part, Borneolum Syntheticum 1-3 part, Fructus Aurantii Immaturus 4-6 part.
Carry out preferably above-mentioned Chinese medicine composition, most preferred weight portion is: carry out preferably to above-mentioned Chinese medicine composition: Radix Notoginseng 15 parts, Semen Plantaginis 5 parts, Ramulus Uncariae Cum Uncis 12 parts, 12 parts, the Radix Rehmanniae, 14 parts, Radix Glycyrrhizae, Fructus Tritici Levis 20 parts, Fructus Crataegi 25 parts, Spica Prunellae 12 parts, the Cortex Eucommiae 20 parts, Pericarpium Citri Reticulatae 30 parts, Borneolum Syntheticum 1 part, Fructus Aurantii Immaturus 4 parts.
According to Chinese medical theory, the pharmacological action of the Chinese medicine used in Chinese medicine composition prescription of the present invention is as follows:
Radix Notoginseng sweet in the mouth, micro-hardship, warm in nature, return liver, stomach warp.
Function cures mainly: dissipating blood stasis stops blooding, subduing swelling and relieving pain.For spitting of blood, spit blood, epistaxis, has blood in stool, metrorrhagia, traumatic hemorrhage, and breast abdomen twinges, tumbling and swelling.
Semen Plantaginis sweet in the mouth, cold in nature, return liver, kidney, lung, small intestine meridian.
Function cures mainly: clearing away heat and promoting diuresis, and eliminating dampness by diuresis is treating stranguria, and improving eyesight is eliminated the phlegm.For edema distension, the puckery pain of pyretic stranguria, diarrhea due to summer heat and dampness, conjunctival congestion and swelling pain, phlegm-heat cough.
Ramulus Uncariae Cum Uncis sweet in the mouth, cool in nature, return liver, pericardium channel.
Function cures mainly: heat clearing away suppressing the hyperactive liver, dispelling wind and relieving convulsion.Dizzy for having a headache, dysphoric cold, infantile convulsion is twitched, pre-eclampsia; Hypertension.
Radix Rehmanniae sweet in the mouth, cold in nature, GUIXIN, liver, kidney channel.The Radix Rehmanniae cure the wound cold epidemic febrile disease answer diaphoresis and not antiperspirant it, interior blood-retention person, and control epistaxis, spit blood endless
Radix Glycyrrhizae sweet in the mouth, property is put down, GUIXIN, lung, spleen, stomach warp.
Function cures mainly: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.
Fructus Tritici Levis sweet in the mouth; Cool in nature, heart channel
Function cures mainly: except deficiency-heat; Hidroschesis.Main only fever due to yin deficiency; Night sweat; Spontaneous perspiration
Fructus Crataegi sweet in the mouth; Cool in nature, heart channel
Function cures mainly: except deficiency-heat; Hidroschesis.Main only fever due to yin deficiency; Night sweat; Spontaneous perspiration
Spica Prunellae acrid in the mouth, hardship, cold in nature, return liver, gallbladder meridian.
Function cures mainly: relieve inflammation or internal heat, improving eyesight, eliminating stagnation, detumescence.For conjunctival congestion and swelling pain, order pearl nyctalgia, has a headache dizzy, scrofula, goiter, and acute mastitis swells and ache; Thyromegaly, tuberculous lymphadenitis, cyclomastopathy, hypertension.
Cortex Eucommiae sweet in the mouth, temperature, returns liver, kidney channel.
Function cures mainly: invigorating the liver and kidney, and bone and muscle strengthening is antiabortive.For lumbago due to renal deficiency, muscles and bones is unable, blood leaking in gestation, frequent fetal movement; Hypertension.
Pericarpium Citri Reticulatae bitter in the mouth, pungent, warm in nature, return lung, spleen channel.
Function cures mainly: regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm.For fullness in the epigastrium and chest, lack of appetite and vomiting, cough with copious phlegm.
Borneolum Syntheticum is pungent, bitter, is slightly cold, GUIXIN, spleen, lung meridian.
Function cures mainly: refreshment of having one's ideas straightened out, clearing away heat to alleviate pain.Faint for calentura coma, convulsion, apoplexy syncope due to accumulation of phlegm, stagnation of QI sudden syncope, attacked by pestiferous factors is gone into a coma, and conjunctival congestion, aphtha, laryngopharynx swelling and pain, auditory meatus is suppurated.
Fructus Aurantii Immaturus bitter in the mouth, pungent, sour, warm in nature, return spleen, stomach warp.
Function cures mainly: dispelling the stagnated QI removing food stagnancy, loose painful abdominal mass of reducing phlegm, and stops, feeling of fullness distending pain in stagnant, heavy after dysentery, constipation, the stagnant vapour lock thoracic obstruction of expectorant, blocked-up chest.
The present invention with Radix Notoginseng and Semen Plantaginis for monarch drug, Radix Notoginseng can also shorten anticoagulation time, there is antiplatelet aggregation and thrombolytic effect, the propagation of hematopoietic stem cell can be promoted simultaneously, there is hemopoietic function, decreased heart rate, all protective effect is had to various drug-induced arrhythmia, Semen Plantaginis can reduce myocardial oxygen consumption and coefficient of oxygen utilization, expansion of cerebral vascular, strengthens cerebral blood flow; Ramulus Uncariae Cum Uncis, the Radix Rehmanniae, the Cortex Eucommiae are that just ministerial drug and monarch drug are associated with, promoting blood circulation to restore menstrual flow, expelling wind and removing dampness, antihypertensive effect; Borneolum Syntheticum, Fructus Aurantii Immaturus act on lesions position for making guiding drug lead full side, and other are condiment, strengthen immunity, compatibility is kind outstanding, be applicable to hypertension dizziness headache person.
Above-mentioned Chinese medicine composition, mainly water decoction, its preparation method is:
(1) each crude drug is filtered out according to each proportioning raw materials, for subsequent use after remove impurity;
(2) first use cold water soak 20 minutes before decocting, pulled out into marmite, after the cold water of the medical material 3 times that reinjects boils with high heat, after slow fire is fried open, slowly decoct 30 minutes again, pour out decocting liquid 250ml, then add the pure water of 200ml, slowly 20 minutes are decocted, pour out decocting liquid 200ml again, then add the water of 400ml, continue to decoct 30 minutes slowly, poured out by decocting liquid, the decocting liquid poured out with first twice mixes and stirs evenly.
The purposes of water decoction described in preparation method as above in treatment hypertension.
Compared with prior art, the hypertensive Chinese medicine composition for the treatment of of the present invention compared with prior art has outstanding beneficial effect, is mainly manifested in:
(1) reduce blood pressure reposefully, improve well and eliminate clinical symptoms, after drug withdrawal a period of time, the rebound phenomena chance of blood pressure is very little, is significantly better than Western medicine.
(2) preparation method provided by the invention, easy and simple to handle, water decoction can be applicable to individual patients and take, and it is high that therapeutic effect of the present invention has curative effect, instant effect, the features such as short treating period, and expense is low, safety non-toxic side reaction, finds through clinical trial, medicine system of the present invention significantly can reduce the misery of patient, has higher social value.
Specific embodiment
Embodiment 1:
Radix Notoginseng 5g, Semen Plantaginis 1g, Ramulus Uncariae Cum Uncis 2g, Radix Rehmanniae 5g, Radix Glycyrrhizae 8g, Fructus Tritici Levis 8g, Fructus Crataegi 10g, Spica Prunellae 1g, Cortex Eucommiae 15g, Pericarpium Citri Reticulatae 20g, Borneolum Syntheticum 1g, Fructus Aurantii Immaturus 1g.
Preparation technology:
(1) each crude drug is filtered out according to each proportioning raw materials, for subsequent use after remove impurity;
(2) first use cold water soak 20 minutes before decocting, pulled out into marmite, after the cold water of the medical material 3 times that reinjects boils with high heat, after slow fire is fried open, slowly decoct 30 minutes again, pour out decocting liquid 250ml, then add the pure water of 200ml, slowly 20 minutes are decocted, pour out decocting liquid 200ml again, then add the water of 400ml, continue to decoct 30 minutes slowly, poured out by decocting liquid, the decocting liquid poured out with first twice mixes and stirs evenly.
Embodiment 2
Radix Notoginseng 20g, Semen Plantaginis 10g, Ramulus Uncariae Cum Uncis 20g, Radix Rehmanniae 20g, Radix Glycyrrhizae 20g, Fructus Tritici Levis 32g, Fructus Crataegi 40g, Spica Prunellae 15g, Cortex Eucommiae 25g, Pericarpium Citri Reticulatae 40g, Borneolum Syntheticum 5g, Fructus Aurantii Immaturus 8g.
Preparation technology:
(1) each crude drug is filtered out according to each proportioning raw materials, for subsequent use after remove impurity;
(2) first use cold water soak 20 minutes before decocting, pulled out into marmite, after the cold water of the medical material 3 times that reinjects boils with high heat, after slow fire is fried open, slowly decoct 30 minutes again, pour out decocting liquid 250ml, then add the pure water of 200ml, slowly 20 minutes are decocted, pour out decocting liquid 200ml again, then add the water of 400ml, continue to decoct 30 minutes slowly, poured out by decocting liquid, the decocting liquid poured out with first twice mixes and stirs evenly.
Embodiment 3
Radix Notoginseng 10g, Semen Plantaginis 5g, Ramulus Uncariae Cum Uncis 8g, Radix Rehmanniae 10g, Radix Glycyrrhizae 12g, Fructus Tritici Levis 15g, Fructus Crataegi 20g, Spica Prunellae 10g, Cortex Eucommiae 18g, Pericarpium Citri Reticulatae 25g, Borneolum Syntheticum 1g, Fructus Aurantii Immaturus 4g.
Preparation technology:
(1) each crude drug is filtered out according to each proportioning raw materials, for subsequent use after remove impurity;
(2) first use cold water soak 20 minutes before decocting, pulled out into marmite, after the cold water of the medical material 3 times that reinjects boils with high heat, after slow fire is fried open, slowly decoct 30 minutes again, pour out decocting liquid 250ml, then add the pure water of 200ml, slowly 20 minutes are decocted, pour out decocting liquid 200ml again, then add the water of 400ml, continue to decoct 30 minutes slowly, poured out by decocting liquid, the decocting liquid poured out with first twice mixes and stirs evenly.
Embodiment 4
Radix Notoginseng 15g, Semen Plantaginis 8g, Ramulus Uncariae Cum Uncis 15g, Radix Rehmanniae 15g, Radix Glycyrrhizae 15g, Fructus Tritici Levis 25g, Fructus Crataegi 30g, Spica Prunellae 15g, Cortex Eucommiae 22g, Pericarpium Citri Reticulatae 35g, Borneolum Syntheticum 3g, Fructus Aurantii Immaturus 6g.
Preparation technology:
(1) each crude drug is filtered out according to each proportioning raw materials, for subsequent use after remove impurity;
(2) first use cold water soak 20 minutes before decocting, pulled out into marmite, after the cold water of the medical material 3 times that reinjects boils with high heat, after slow fire is fried open, slowly decoct 30 minutes again, pour out decocting liquid 250ml, then add the pure water of 200ml, slowly 20 minutes are decocted, pour out decocting liquid 200ml again, then add the water of 400ml, continue to decoct 30 minutes slowly, poured out by decocting liquid, the decocting liquid poured out with first twice mixes and stirs evenly.
Embodiment 5
Radix Notoginseng 15g, Semen Plantaginis 5g, Ramulus Uncariae Cum Uncis 12g, Radix Rehmanniae 12g, Radix Glycyrrhizae 14g, Fructus Tritici Levis 20g, Fructus Crataegi 25g, Spica Prunellae 12g, Cortex Eucommiae 20g, Pericarpium Citri Reticulatae 30g, Borneolum Syntheticum 1g, Fructus Aurantii Immaturus 4g.
Preparation technology:
(1) each crude drug is filtered out according to each proportioning raw materials, for subsequent use after remove impurity;
(2) first use cold water soak 20 minutes before decocting, pulled out into marmite, after the cold water of the medical material 3 times that reinjects boils with high heat, after slow fire is fried open, slowly decoct 30 minutes again, pour out decocting liquid 250ml, then add the pure water of 200ml, slowly 20 minutes are decocted, pour out decocting liquid 200ml again, then add the water of 400ml, continue to decoct 30 minutes slowly, poured out by decocting liquid, the decocting liquid poured out with first twice mixes and stirs evenly.
Embodiment 6: prescriptions of Chinese medicine is verified
1. case quantity
Chinese medicine of the present invention was in 2009 to 2014 the routine patients of clinical observation depression 231, and the age is from 45-60 year.
2. Therapeutic Method
The water decoction of embodiment 1-5, according to the different choice of the state of an illness.
3, instructions of taking: each 1 dose, every day 2 times 3 weeks was 1 course for the treatment of.
4, therapeutic effect:
1), we carry out grouping medication to 231 hyperpietics, and blood pressure measurement adopts approved mercury column meter, require that tested patient peace and quiet are had a rest 10 minutes, upper arm brachial artery position blood pressure when measuring quiet rest seat.The effective criterion of hypertension: be normal value during measurement below 140/90mmHg.After drug withdrawal, bounce-back standard is: measure high pressure blood pressure after referring to drug withdrawal and be all greater than normal value 140/90mmHg; Effective: to refer to that the ratio of the blood pressure after taking medicine reduces before taking medicine; Invalid: to refer to that front and back blood pressure of taking medicine does not have significant change; Cure: refer to that the blood pressure after taking medicine is normal value.The results are shown in Table 1.
The controlling of blood pressure situation of table 1 experimenter after 30 days
2) result: in 231 routine patients, the Western medicine losartan instant effect that A group uses, but there is certain dependency and rebound rate is higher, reach 100%; The rebound rate of Chinese medicine and western medicine is less than Western medicine, but antihypertensive effect is not obvious, and effective percentage only 48.5%, embodiment is respectively organized and is obviously better than A, B group, and effective percentage and rebound rate have significant technique effect.
5. model case
Case 1: Sui, Distributions in Liaocheng of Shandong Province people, 48 years old, female, the unreasonable blood pressure that causes of long-term meals raised, and carrying out blood pressure after my institute side amount is 160/110mmHg, by the Chinese medicinal formulae that the formula of the embodiment of the present invention 5 is obtained, three courses for the treatment of, to be almost recovered and without rebound phenomena.
Case 2: Hao, people from Linshu, Shandong, 53 years old, man, long-term alcohol, accidentally fall in a busy farming season, after diagnosing, cerebral blood supply insufficiency causes, 170/110mmHg is reached through its blood pressure of examination in hospital, carry out the treatment of my institute by the obtained Chinese medicinal formulae of the formula of the embodiment of the present invention 5, two courses for the treatment of, to be almost recovered and without rebound phenomena.
Case 3: Zhang, people from Xuzhou, 45 years old, female, rural people, had hypertension for a long time, introduces through relative, carrys out the treatment of my institute, by the Chinese medicinal formulae that the formula of embodiments of the invention 2 is obtained, through treating two courses for the treatment of, to be almost recovered and without rebound phenomena after taking.
Case 4: grandson, people from Linyi, Shandong, 53 years old, man, familial heredity hypertension, long-term taking Western medicine preparation valsartan, blood pressure always raises repeatedly, and by the agency of carrys out my institute's treatment, by the Chinese medicinal formulae that the formula of embodiments of the invention 5 is obtained, through treating two courses for the treatment of, rebound phenomena reduces.
Case 5: Hao, Lianyungang of Jiangsu people, 65 years old, female, falls in a swoon on ground in the process of once nursing child, comes my institute and rescues, owing to rescuing in time, recovered normal sign, but blood pressure high pressure is always at more than 160mmHg, through inquiry patient high pressure always, do not carry out Drug therapy, the Chinese medicinal formulae that the formula of embodiments of the invention 1 is obtained, through treating two courses for the treatment of, is almost recovered.
Claims (6)
1. treat a hypertensive Chinese medicine composition, it is characterized in that, be made up of following bulk drugs: seven, Semen Plantaginis, Ramulus Uncariae Cum Uncis, the Radix Rehmanniae, Radix Glycyrrhizae, Fructus Tritici Levis, Fructus Crataegi, Spica Prunellae, the Cortex Eucommiae, Pericarpium Citri Reticulatae, Borneolum Syntheticum, Fructus Aurantii Immaturus.
2. Chinese medicine composition according to claim 1, it is characterized in that, be made up of the crude drug of following weight portion: Radix Notoginseng 5-20 part, Semen Plantaginis 1-10 part, Ramulus Uncariae Cum Uncis 2-20 part, Radix Rehmanniae 5-20 part, Radix Glycyrrhizae 8-20 part, Fructus Tritici Levis 8-32 part, Fructus Crataegi 10-40 part, Spica Prunellae 1-15 part, Cortex Eucommiae 15-25 part, Pericarpium Citri Reticulatae 20-40 part, Borneolum Syntheticum 1-5 part, Fructus Aurantii Immaturus 1-8 part.
3. Chinese medicine composition according to claim 1, it is characterized in that, be made up of the crude drug of following weight portion: Radix Notoginseng 10-15 part, Semen Plantaginis 5-8 part, Ramulus Uncariae Cum Uncis 8-15 part, Radix Rehmanniae 10-15 part, Radix Glycyrrhizae 12-15 part, Fructus Tritici Levis 15-25 part, Fructus Crataegi 20-30 part, Spica Prunellae 10-15 part, Cortex Eucommiae 18-22 part, Pericarpium Citri Reticulatae 25-35 part, Borneolum Syntheticum 1-3 part, Fructus Aurantii Immaturus 4-6 part.
4. Chinese medicine composition according to claim 1, it is characterized in that, be made up of the crude drug of following weight portion: Radix Notoginseng 15 parts, Semen Plantaginis 5 parts, Ramulus Uncariae Cum Uncis 12 parts, 12 parts, the Radix Rehmanniae, 14 parts, Radix Glycyrrhizae, Fructus Tritici Levis 20 parts, Fructus Crataegi 25 parts, Spica Prunellae 12 parts, the Cortex Eucommiae 20 parts, Pericarpium Citri Reticulatae 30 parts, Borneolum Syntheticum 1 part, Fructus Aurantii Immaturus 4 parts.
5. prepare a Chinese medicine composition according to claim 1, it is characterized in that, concrete steps are:
(1) each crude drug is filtered out according to each proportioning raw materials, for subsequent use after remove impurity;
(2) first use cold water soak 20 minutes before decocting, pulled out into marmite, after the cold water of the medical material 3 times that reinjects boils with high heat, after slow fire is fried open, slowly decoct 30 minutes again, pour out decocting liquid 250ml, then add the pure water of 200ml, slowly 20 minutes are decocted, pour out decocting liquid 200ml again, then add the water of 400ml, continue to decoct 30 minutes slowly, poured out by decocting liquid, the decocting liquid poured out with first twice mixes and stirs evenly.
6. the Chinese medicine composition according to any one of claim 1-5, is characterized in that, described Chinese medicine composition is treating hypertensive purposes.
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Application publication date: 20151125 |