CN105213905A - A kind of Chinese medicine composition and application thereof preventing and treating postmenopausal osteoporosis - Google Patents

Abstract

Prevent and treat a Chinese medicine composition for postmenopausal osteoporosis, the crude drug of described Chinese medicine composition by the Radix Paeoniae Alba, Caulis Polygoni Multiflori, Herba Epimedii, Fructus Ligustri Lucidi, Semen Cuscutae, Rhizoma Polygoni Cuspidati, Radix Ginseng Rubra, Herba Ecliptae, Radix Rhodiolae, rub Bai Ye, Herba Cistanches, the Cortex Eucommiae, Fructus Lycii, Radix seu Caulis Jasmini lanceolarii, Caulis Spatholobi, Herba Taxilli, Radix Polygoni Multiflori Preparata, Herba Agrimoniae, Flos Carthami, Radix Gentianae Macrophyllae, Placenta Hominis, Rhizoma Sparganii, Herba Saussureae Involueratae, Sanguis Draxonis, Herba Leonuri, Radix Notoginseng, Radix Puerariae, Radix Morindae Officinalis, Rhizoma Gastrodiae, Semen Sesami Nigrum form.Selected by Chinese medicine composition of the present invention, medical material compatibility is suitable, meet Chinese medicine and pharmacy and modern medicine theory, its compatibility meets Chinese medicine " monarch " principle, unique curative effect is had to postmenopausal osteoporosis, this medicine compatibility science, curative effect is rapid, the advantage that instant effect, short treating period, cure rate are high, expense is little.

Description

A kind of Chinese medicine composition and application thereof preventing and treating postmenopausal osteoporosis

Technical field

The invention belongs to medical art, relate to a kind of Chinese medicine composition, be specifically related to a kind of Chinese medicine composition and the application thereof that prevent and treat postmenopausal osteoporosis.

Background technology

Osteoporosis (osteoporosis) is a kind of with bone amount minimizing, and the fine structure of bone destroys as feature, and the fragility causing bone increases, and is easy to a kind of general osteopathia of fracturing.Osteoporosis can be divided into three major types: primary osteoporosis, secondary osteoporosis and idiopathic osteoporosis.First kind primary osteoporosis can be divided into again osteoporosis (I type) and the senile osteoporosis (II type) of menopausal women; Equations of The Second Kind is secondary osteoporosis, and it is by other diseases (as renal failure, excess thyroid hormone or leukemia), or some factors such as medicine (as steroid) the osteoporosis of being brought out; 3rd class is idiopathic osteoporosis, is more common in teenager or the adult of 8 ~ 14 years old, mostly has hereditary family history, and women is more than male, and the osteoporosis that forepart pregnant women and age of sucking occur also can list idiopathic osteoporosis in.

Osteoporosis is common ailment of middle-aged and old, frequently-occurring disease, have a strong impact on the Health and Living quality of such crowd, osteoporosis and the fracture caused thereof occupy the 7th in current common disease, during serious threat, the health of old people, make it the public health problem becoming the whole world.At present, aged tendency of population is day by day serious, improves and has very important significance to the control consciousness of osteoporosis.Osteoporosis reduces with bone amount, comprise the minimizing of bone mineral and substrate equal proportion, osseous tissue microstructure deteriorates to feature, show as trabecular bone structure to destroy, attenuate and rupture, and then cause the fragility of bone to increase, biomechanics of bone intensity declines, load holding capacity reduces, and is easy to a kind of systemic skeletal disease that capillary fracture or complete fracture occur.Patients with osteoporosis cardinal symptom is lumbar and back pain, hunchback, easily fractures clinically, and many with performance of suffering from a deficiency of the kidney, and as lumbar and back pain, hyposexuality etc., has had a strong impact on life and quality of life.According to the United Nations's statistics aging, oneself becomes 21 century irreversible worldwide trend.And China entered aging society in 1999.Chinese society's aging speed is faster than country's total population growth rate, according to incompletely statistics, the senile osteoporosis disease sickness rate of China more than 60 years old is about 59.89%, therefore increases bone density, effectively treatment osteoporosis and has become the important topic of people's extensive concern.

In the world's osteoporosis conference in 2004 of international osteoporosis foundation (IOF), Univ Sheffield UK's WHO metabolic osteopathy research center Johnell etc. analyzes 12 clinical researches, and 30,000 9 thousand people in 12 cohort studies are included in this research in.Find that bone density value is lower, the probability of osteoporotic fracture (with all kinds fracture) is higher, and this situation rule in 65 years old age group is the most obvious.Bone density (BMD) full name is bone mineral density, is an important indicator of bone strength, and the intensity of osseous tissue has 75% ~ 85% relevant with bone density.The bone density of bone density phalanges unit are, refers to and the tightness degree that osseous tissue combines is often referred to bone mineral content.Be weigh an osteoporotic index objectively quantized at present, be also an index of reflection bone amount, its unit is g/c ㎡, and bone density is higher, and sclerotin intensity is better.It is relevant to factors such as skeletal structure, bone amount, bone mineral contents.

Modern medicine thinks that postmenopausal osteoporosis is a kind of commonly encountered diseases relevant with aging, mainly occur in postmenopausal women group, because estrogen deficiency causes bone amount to reduce and bone structure change, bone fragility is increased and is easy to fracture, and pain, the textured bone to cause by fracturing, there is complication, so the problem such as death, seriously affect the healthy of old people and quality of life, even shorten the life-span, increase country and family's financial resources and manpower burden.Osteoporosis is a kind of commonly encountered diseases of postmenopausal women, frequently-occurring disease, and harm is day by day serious, is called as " silent epidemic diseases ", has caused global concern.Clinical disease shows: have a back ache the earliest, thereupon Vertebral Compression, also can with deformity of spine, bow-backedly becomes short etc., and severe patient can cause chest deformity, affect pulmonary function, concurrent fracture, and along with the increase at age, the danger increase of fracture.At present to this disease western medical treatment method many employings complementing estrogen, calcium preparation and vitamin, but taking estrogen in a large number likely causes the side effect such as carcinoma of endometrium and mastocarcinoma for a long time, and calcium preparation and replenishing on dosage of vitamin are difficult to again control.

At present, relevant to menopause osteoporosis has been very important important health care problem.Postmenopausal osteoporosis is multifactor property disease, and heredity, life style, nutrition etc. are all relevant with morbidity.There is following high risk factor person and easily suffer from postmenopausal osteoporosis: white man and Asia women, have osteoporosis family history or have the special gene affecting bone amount women, calcium Deficiency of Intake, lack physical exertion, a large amount of smoking and drink, early menopause or menopause move ahead Bilateral oophorectomy patient.Whether there is osteoporosis, depend on the speed of its peak bone mass and bone loss thereof, peak bone mass high and (or) the slow person of bone loss, not easily occur, peak bone mass low and (or) the fast person of bone loss easily occurs.

The difference of producing cause and the mechanism of action is lacked according to bone density, diverse ways can be selected to increase bone density, current clinical treatment many employings calcium preparation, activated vitamin D, gonadal hormone, calcitonin, diphosphonate and fluoride etc., though there is certain curative effect, but side effect is large, somewhat expensive, and cure the symptoms, not the disease.In treatment, western medicine still lacks measure effectively, and medicinal application is also very limited.Simple replenishing the calcium only can delay but can not stop the loss of bone amount, therefore a kind of efficient supplementing of research and development is run off calcareous and can consolidate and prevent bone amount to run off and safe without toxic side effect, thus fundamentally solves osteoporotic medicine and become the problem urgently needing to solve.

Summary of the invention

The object of the invention is to solve the weak point that above-mentioned prior art exists, provide a kind of and effectively can prevent and treat postmenopausal osteoporosis and instant effect, short treating period, Chinese medicine composition that cure rate is high.

Above-mentioned purpose of the present invention is realized by following technical proposals:

Prevent and treat a Chinese medicine composition for postmenopausal osteoporosis, the crude drug of described Chinese medicine composition by the Radix Paeoniae Alba, Caulis Polygoni Multiflori, Herba Epimedii, Fructus Ligustri Lucidi, Semen Cuscutae, Rhizoma Polygoni Cuspidati, Radix Ginseng Rubra, Herba Ecliptae, Radix Rhodiolae, rub Bai Ye, Herba Cistanches, the Cortex Eucommiae, Fructus Lycii, Radix seu Caulis Jasmini lanceolarii, Caulis Spatholobi, Herba Taxilli, Radix Polygoni Multiflori Preparata, Herba Agrimoniae, Flos Carthami, Radix Gentianae Macrophyllae, Placenta Hominis, Rhizoma Sparganii, Herba Saussureae Involueratae, Sanguis Draxonis, Herba Leonuri, Radix Notoginseng, Radix Puerariae, Radix Morindae Officinalis, Rhizoma Gastrodiae, Semen Sesami Nigrum form.

Further, raw material composition and the parts by weight of making described Chinese medicine composition are: Radix Paeoniae Alba 12-20 part, Herba Epimedii 10-16 part, Fructus Ligustri Lucidi 3-8 part, Semen Cuscutae 5-12 part, Caulis Polygoni Multiflori 12-17 part, Radix Ginseng Rubra 7-12 part, Flos Carthami 4-9 part, Herba Ecliptae 15-20 part, Radix Rhodiolae 10-15 part, rub Bai Ye 8-12 part, Herba Cistanches 2-5 part, Fructus Lycii 3-7 part, Caulis Spatholobi 11-14 part, Radix seu Caulis Jasmini lanceolarii 9-15 part, Herba Taxilli 3-6 part, Radix Polygoni Multiflori Preparata 8-13 part, Herba Saussureae Involueratae 3-5 part, Cortex Eucommiae 1-3 part, Herba Agrimoniae 5-10 part, Radix Notoginseng 5-10 part, Rhizoma Polygoni Cuspidati 13-16 part, Radix Gentianae Macrophyllae 3-10 part, Placenta Hominis 8-13 part, Rhizoma Sparganii 3-5 part, Sanguis Draxonis 1-3 part, Radix Puerariae 5-10 part, Herba Leonuri 3-6 part, Radix Morindae Officinalis 8-13 part, Rhizoma Gastrodiae 3-5 part, Semen Sesami Nigrum 13-16 part.

Further, raw material composition and the parts by weight of making described Chinese medicine composition are: the Radix Paeoniae Alba 12 parts, Herba Epimedii 16 parts, Fructus Ligustri Lucidi 3 parts, Semen Cuscutae 12 parts, Caulis Polygoni Multiflori 12 parts, Radix Ginseng Rubra 10 parts, 9 parts, Flos Carthami, Herba Ecliptae 15 parts, Radix Rhodiolae 15 parts, rub Bai Ye 8 parts, Herba Cistanches 5 parts, Fructus Lycii 3 parts, Caulis Spatholobi 14 parts, Radix seu Caulis Jasmini lanceolarii 9 parts, Herba Taxilli 6 parts, Radix Polygoni Multiflori Preparata 8 parts, Herba Saussureae Involueratae 5 parts, the Cortex Eucommiae 1 part, Herba Agrimoniae 10 parts, Radix Notoginseng 5 parts, Rhizoma Polygoni Cuspidati 16 parts, Radix Gentianae Macrophyllae 10 parts, Placenta Hominis 8 parts, Rhizoma Sparganii 5 parts, Sanguis Draxonis 1 part, Radix Puerariae 10 parts, Herba Leonuri 6 parts, Radix Morindae Officinalis 8 parts, 3 parts, Rhizoma Gastrodiae, Semen Sesami Nigrum 13 parts.

Further, raw material composition and the parts by weight of making described Chinese medicine composition are: the Radix Paeoniae Alba 20 parts, Herba Epimedii 10 parts, Fructus Ligustri Lucidi 8 parts, Semen Cuscutae 5 parts, Caulis Polygoni Multiflori 17 parts, Radix Ginseng Rubra 12 parts, 4 parts, Flos Carthami, Herba Ecliptae 20 parts, Radix Rhodiolae 10 parts, rub Bai Ye 12 parts, Herba Cistanches 2 parts, Fructus Lycii 7 parts, Caulis Spatholobi 11 parts, Radix seu Caulis Jasmini lanceolarii 15 parts, Herba Taxilli 3 parts, Radix Polygoni Multiflori Preparata 13 parts, Herba Saussureae Involueratae 3 parts, the Cortex Eucommiae 3 parts, Herba Agrimoniae 5 parts, Radix Notoginseng 10 parts, Rhizoma Polygoni Cuspidati 13 parts, Radix Gentianae Macrophyllae 3 parts, Placenta Hominis 13 parts, Rhizoma Sparganii 3 parts, Sanguis Draxonis 3 parts, Radix Puerariae 5 parts, Herba Leonuri 4 parts, Radix Morindae Officinalis 10 parts, 4 parts, Rhizoma Gastrodiae, Semen Sesami Nigrum 16 parts.

Further, raw material composition and the parts by weight of making described Chinese medicine composition are: the Radix Paeoniae Alba 13 parts, Herba Epimedii 11 parts, Fructus Ligustri Lucidi 4 parts, Semen Cuscutae 6 parts, Caulis Polygoni Multiflori 13 parts, Radix Ginseng Rubra 7 parts, 5 parts, Flos Carthami, Herba Ecliptae 18 parts, Radix Rhodiolae 11 parts, rub Bai Ye 9 parts, Herba Cistanches 4 parts, Fructus Lycii 6 parts, Caulis Spatholobi 12 parts, Radix seu Caulis Jasmini lanceolarii 13 parts, Herba Taxilli 4 parts, Radix Polygoni Multiflori Preparata 9 parts, Herba Saussureae Involueratae 4 parts, the Cortex Eucommiae 2 parts, Herba Agrimoniae 6 parts, Radix Notoginseng 6 parts, Rhizoma Polygoni Cuspidati 14 parts, Radix Gentianae Macrophyllae 5 parts, Placenta Hominis 10 parts, Rhizoma Sparganii 4 parts, Sanguis Draxonis 2 parts, Radix Puerariae 6 parts, Herba Leonuri 5 parts, Radix Morindae Officinalis 12 parts, 3 parts, Rhizoma Gastrodiae, Semen Sesami Nigrum 14 parts.

Further, raw material composition and the parts by weight of making described Chinese medicine composition are: the Radix Paeoniae Alba 17 parts, Herba Epimedii 15 parts, Fructus Ligustri Lucidi 7 parts, Semen Cuscutae 11 parts, Caulis Polygoni Multiflori 16 parts, Radix Ginseng Rubra 8 parts, 8 parts, Flos Carthami, Herba Ecliptae 16 parts, Radix Rhodiolae 14 parts, rub Bai Ye 11 parts, Herba Cistanches 3 parts, Fructus Lycii 5 parts, Caulis Spatholobi 13 parts, Radix seu Caulis Jasmini lanceolarii 14 parts, Herba Taxilli 5 parts, Radix Polygoni Multiflori Preparata 12 parts, Herba Saussureae Involueratae 3 parts, the Cortex Eucommiae 1 part, Herba Agrimoniae 10 parts, Radix Notoginseng 9 parts, Rhizoma Polygoni Cuspidati 13 parts, Radix Gentianae Macrophyllae 7 parts, Placenta Hominis 11 parts, Rhizoma Sparganii 3 parts, Sanguis Draxonis 1 part, Radix Puerariae 10 parts, Herba Leonuri 4 parts, Radix Morindae Officinalis 11 parts, 4 parts, Rhizoma Gastrodiae, Semen Sesami Nigrum 15 parts.

Further, raw material composition and the parts by weight of making described Chinese medicine composition are: the Radix Paeoniae Alba 15 parts, Herba Epimedii 12 parts, Fructus Ligustri Lucidi 5 parts, Semen Cuscutae 9 parts, Caulis Polygoni Multiflori 15 parts, Radix Ginseng Rubra 9 parts, 7 parts, Flos Carthami, Herba Ecliptae 19 parts, Radix Rhodiolae 13 parts, rub Bai Ye 10 parts, Herba Cistanches 4 parts, Fructus Lycii 4 parts, Caulis Spatholobi 11 parts, Radix seu Caulis Jasmini lanceolarii 11 parts, Herba Taxilli 5 parts, Radix Polygoni Multiflori Preparata 10 parts, Herba Saussureae Involueratae 5 parts, the Cortex Eucommiae 3 parts, Herba Agrimoniae 8 parts, Radix Notoginseng 8 parts, Rhizoma Polygoni Cuspidati 14 parts, Radix Gentianae Macrophyllae 9 parts, Placenta Hominis 12 parts, Rhizoma Sparganii 5 parts, Sanguis Draxonis 3 parts, Radix Puerariae 8 parts, Herba Leonuri 6 parts, Radix Morindae Officinalis 9 parts, 5 parts, Rhizoma Gastrodiae, Semen Sesami Nigrum 14 parts.

Further, raw material composition and the parts by weight of making described Chinese medicine composition are: the Radix Paeoniae Alba 19 parts, Herba Epimedii 14 parts, Fructus Ligustri Lucidi 6 parts, Semen Cuscutae 7 parts, Caulis Polygoni Multiflori 14 parts, Radix Ginseng Rubra 9 parts, 6 parts, Flos Carthami, Herba Ecliptae 17 parts, Radix Rhodiolae 13 parts, rub Bai Ye 10 parts, Herba Cistanches 4 parts, Fructus Lycii 4 parts, Caulis Spatholobi 11 parts, Radix seu Caulis Jasmini lanceolarii 11 parts, Herba Taxilli 5 parts, Radix Polygoni Multiflori Preparata 10 parts, Herba Saussureae Involueratae 5 parts, the Cortex Eucommiae 3 parts, Herba Agrimoniae 8 parts, Radix Notoginseng 8 parts, Rhizoma Polygoni Cuspidati 14 parts, Radix Gentianae Macrophyllae 4 parts, Placenta Hominis 9 parts, Rhizoma Sparganii 5 parts, Sanguis Draxonis 3 parts, Radix Puerariae 8 parts, Herba Leonuri 3 parts, Radix Morindae Officinalis 8 parts, 5 parts, Rhizoma Gastrodiae, Semen Sesami Nigrum 16 parts.

Further, described Chinese medicine composition is prepared by the following method:

(1) each medical material of components by weight percent in described Chinese medicine composition is got, be ground into coarse powder, the alcoholic solution that volumetric concentration is 70%-95% is doubly added according to the 4-10 of coarse powder gross weight, reflux, extract, three times, return time is 3-5h, filters, filtrate recycling ethanol, cold filtration, washes with water, obtains dry extract after drying;

(2) pulverized by dry extract obtained for step (1), add suitable amount of sucrose, dextrin mixing, take ethanol as wetting agent, granulate, dry, granulate, can obtain granule; Or the dry extract that step (1) is obtained dry, pulverize, and makes powder; Or dry extract obtained for step (1) is pulverized, adds appropriate micropowder silica gel, α-galactose mixing, take ethanol as wetting agent, granulate, dry, granulate, encapsulated, obtained capsule; Or dry extract obtained for step (1) is pulverized, adds suitable amount of sucrose, dextrin mixing, take ethanol as wetting agent, granulate, dry, granulate, tabletting, obtained tablet; Or to above-mentioned steps (1) obtain centrifugal after concentrated solution in add suitable amount of sucrose, essence mixing, sterilizing, fill, obtained medicinal liquid agent.

The invention still further relates to a kind of application of Chinese medicine composition in control postmenopausal osteoporosis medicine preventing and treating postmenopausal osteoporosis.

The Chinese medicine composition of control postmenopausal osteoporosis provided by the present invention, it for raw material, gives full play to the property of medicine of each component with common Chinese herbal medicine:

The Radix Paeoniae Alba, enters liver, spleen channel, has nourishing blood to suppress the hyperactive liver, pain relieving in slow, and yin fluid astringing receives effect of antiperspirant.Cure mainly the breast abdomen pain over the hypochondriac region, dysentery is suffered from abdominal pain, and spontaneous sweating, fever due to yin deficiency, menoxenia, metrorrhagia, is with inferior disease.Herba Menthae is one of Chinese conventional Chinese medicine.It is pungent cool property sweating antipyretic medicine, controls influenza, the disease such as headache, conjunctival congestion, fever of the body, throat, dental bed swell and ache.External can training the mind dysmenorrhoea, skin pruritus, erythra and eczema etc.The Herba Menthae of light friend Greenhouse Fruit Picking is again the fresh vegetable on dining table in the Spring Festival.Clearly good to eat.Usually with Herba Menthae for tea, clear away heart-fire improving eyesight.Modern medicine proves that Herba Menthae has very strong antiviral and antibacterial activity, and has certain antiallergic activity.

Herba Epimedii, pungent, sweet, warm, return Liver and kidney warp, Compendium of Material Medica is carried: " warm in naturely not tremble with fear, can beneficial vital essence, be the burnt gate of vitality's medicine of brothers Yang Ming tri-also." be all card common medicines of insufficiency of kidney-YANG.Essentials of Matea Medica carries: " mend the gate of vitality, beneficial vital essence, hard muscles and bones, diuresis.”

Fructus Ligustri Lucidi is the dry mature fruit of Oleaceae plants Fructus Ligustri Lucidi LigustrumlucidumAit..Gather during fruit maturation in winter, removing branch and leaf, after slightly steaming or putting in boiling water and slightly scald, dry; Or convection drying.Nature and flavor sweet, bitter, cold.Return liver, kidney channel.Energy nourishing the liver and kidney, improving eyesight black hair.For the hepatic and renal YIN deficiency, dizzy ear toot, soreness of the waist and knees, beard and hair drought is white, and poor vision, interior-heat is quenched one's thirst, osteopyrexia and fever.

Semen Cuscutae: sweet in the mouth, pungent, property is put down, and enters liver,kidney,spleen warp, has the kidney invigorating and essence nourishing, the effect of nourishing the liver to improve visual acuity, be mainly used in the sexual impotence of insufficiency of kidney-YANG, seminal emission premature ejaculation, frequent micturition, dizziness and tinnitus; To suffer from a deficiency of the kidney pain in the lumbar region, married woman's leukorrhagia, nausea is solid; The binocular of both liver and kidney deficiency, deficiency of liver-blood is dim-sighted, blurring of vision; The loose stool stomachache of asthenia of both the spleen and kidney, the symptoms such as aqueous-grainy diarrhea.

Caulis Polygoni Multiflori: sweet micro-hardship is flat.Enter the heart, Liver Channel.Have and nourish heart, calm the nerves, dredging collateral, the effect such as to dispel the wind.Control insomnia, impairment caused by overstrain, hyperhidrosis, blood deficiency general pain, carbuncle, scrofula, wind skin ulcer scabies.

Rhizoma Polygoni Cuspidati: micro-hardship, is slightly cold.Return liver, gallbladder, lung meridian.Function cures mainly expelling wind and removing dampness, dissipating blood stasis analgesic therapy, relieving cough and resolving phlegm.For arthralgia, jaundice due to damp-heat, amenorrhea, lump in the abdomen, burn due to hot liquid or fire, injury from falling down, carbuncle sore tumefacting virus, cough with copious phlegm.

Radix Ginseng Rubra: sweet, micro-hardship, temperature.Return spleen, lung, heart channel.Function cures mainly: strongly invigorating primordial QI, and multiple arteries and veins takes off admittedly, nourishing qi to stop.For weak body and prostration, cold extremities faint pulse, QI failing to control blood, metrostaxis.

Herba Ecliptae, sweet in the mouth, acid, cool in nature, return liver, kidney channel, liver and kidney tonifying; Cooling blood for hemostasis.Main deficiency of the liver and kindey; Have a dizzy spell; Early whitening of beard and hair; Spit blood; Spitting of blood; Epistaxis; Have blood in stool; Dysentery; Collapse; Leak; Traumatic hemorrhage.

Radix Rhodiolae: benefiting QI for activating blood circulation, promotes blood circulation and relievings asthma.There is improving water flood, detumescence is become silted up in blood-enriching and blood-promoting circulation, anti-cerebral anoxia, resisting fatigue, promoting blood circulation and hemostasis, clearing away lung-heat to relieve cough, change, antipyreticly bring down a fever, nourish the effects such as vigour.Select the dry root welding technology of crassulaceae plants Radix Rhodiolae.

Rub Bai Ye, bitter, cool.Heat-clearing and toxic substances removing.For dysentery, acute gastroenteritis, stomatitis, urinary tract infection; Burn and scald is controlled in external, sore swollen toxin, skin pruritus.

Herba Cistanches, sweet, salty, temperature.Return kidney, large intestine channel.Kidney-replenishing, benefiting essence-blood, loosening bowel to relieve constipation.For sexual impotence, infertile, soreness of the waist and knees, muscles and bones is unable, dryness of the intestine constipation." herbal classic ": " main five kinds of strain and seven kinds of impairment, invigorating middle warmer, except stem invasion by pathogenic cold burning pain, support the five internal organs, reinforcing YIN-essence, beneficial vital essence, gynecological mass in abdomen.”

The Cortex Eucommiae: invigorating the liver and kidney, bone and muscle strengthening, antiabortive.Control spinal column ache, there is rubbish in purged body, strengthen human body cell substance metabolism, prevent muscle skeleton aging, balanced human's blood pressure, decomposer inner cholesterol, reduces body fat, recover blood vessel elasticity, diuresis heat clearing away, broad-spectrum antiseptic, stimulating central nervous system, improve white blood cell count, strengthen the remarkable efficacy such as body immunity.

Fructus Lycii: be the dry mature fruit of plant of Solanaceae lycium barbarum LyciumbarbarumL..Nature and flavor are sweet, flat.Return liver, kidney, lung meridian.Effect: nourishing the liver, nourishing kidney.

Radix seu Caulis Jasmini lanceolarii, bitter, temperature.Function cures mainly: expelling wind and removing dampness, promoting blood circulation to remove blood stasis.For bones and muscles pain due to rheumatism, lumbago, traumatic injury.

Caulis Spatholobi: be the dry rattan of pulse family Leguminosae plant spatholobus suberectus SpatholobussuberectusDunn.Nature and flavor are bitter, sweet, temperature.Return liver, kidney channel.Effect: enrich blood, invigorates blood circulation, dredging collateral.

Herba Taxilli: be the stem and branch with leaf of Loranthaceae evergreen dwarf shrub plant Herba Taxilli Loranthusparasiticus (L.) Merr. or Herba Visci Viscumcoloratum (Komar.) Nakai.Nature and flavor bitter, sweet, flat.Return liver, kidney channel.Effect: wind-damp dispelling, liver and kidney tonifying, bone and muscle strengthening." Japan hanako materia medica ": help muscles and bones, beneficial blood vessels.

Radix Polygoni Multiflori Preparata: be the Preparation process product of the dried root of polygonum multiflorum thunb PolygonummultiflorumThunb..Nature and flavor are bitter, sweet, puckery, tepor.Return liver, the heart, kidney channel.Effect: invigorating the liver and kidney, benefiting essence-blood, black beard and hair, bone and muscle strengthening.

Herba Agrimoniae: be the dry aerial parts of rosaceous plant Radix Agrimoniae AgrimoniapiloseLedeb..Nature and flavor are bitter, puckery, flat.GUIXIN, Liver Channel.Effect: astringing to arrest bleeding.

Flos Carthami is warm in nature, acrid in the mouth.Function cures mainly and is applied to latus rectum of invigorating blood circulation, eliminating stasis to stop pain.For amenorrhea, dysmenorrhea, lochia, lump in the abdomen mass in the abdomen, traumatic injury." book on Chinese herbal medicine converge with speech ": Flos Carthami, the medicine of removing blood stasis, promoting the circulation of blood and blood, tune blood also.Main tire produces all kinds of diseases and ailments because blood is for suffering from, or blood is tired of bruise, and coma in silence; Or lochia robs the heart, umbilicus angina abdominis; Or drop slurry is difficult raw; Or afterbirth does not fall, dead fetus in the uterus, be all just before giving birth all cards, non-Flos Carthami can not be controlled.If puerperal blood faints, locked mouth refer to hold in the hand; Or heresy enters blood room, delirium is gone mad; Or blood is vexed interior swollen, sudden syncope with rigidity as extremely, be all puerperal all cards, non-Flos Carthami can not be determined.All as obstructed in amenorrhea and cold and heat are handed over and are done, or expired stomachache and purple black dripping, or injury from falling down and the QI and blood stasis of blood are amassed, or skin infection sufferings and swollen burst uneasy, be the card of all disharmony between QI and blood, non-Flos Carthami can not be adjusted, Flos Carthami promoting blood circulation to restore menstrual flow, reducing swelling and alleviating pain, there are inhibition thrombosis, antiinflammatory, analgesic effect, there is the vasoconstrictive effect eliminating epinephrine, norepinephrine, have " tonneau passages through which vital energy circulates " to act on.

Radix Gentianae Macrophyllae, toil, flat.Enter liver, stomach, gallbladder meridian.Function cures mainly: expelling wind and removing dampness, and blood relaxing muscles and tendons, clearing away heat and promoting diuresis.Dispelling the wind and dampness pathogens arthralgia pain, muscles and bones contracture, jaundice, has blood in stool, osteopyrexia and fever, children's's infantile malnutrition with fever, dysuria.

Placenta Hominis: sweet, salty, warm, mend, feel at ease to nourish blood, QI invigorating, benefit essence, removing toxic substances etc., cure mainly deficient, weakness and emaciation, hemoptysis asthma, consumptive fever hectic fever due to YIN-deficiency, seminal emission etc.

Rhizoma Sparganii: acrid in the mouth; Puckery; Cool.Enter liver.Spleen channel.Control lump in the abdomen, gather, distending pain over the hypochondrium, food stagnation distending pain, dysmenorrhea, amenorrhea, postnatal blood stasis is suffered from abdominal pain, traumatic injury.Cough due to lung-heat controlled by mongolian medicine, asthma abundant expectoration, liver-heat, arteries and veins heat, the hot hectic fever due to YIN-deficiency of consumptive disease, and " precious day " is sick, fracture.

Herba Saussureae Involueratae: Herba Saussureae Involueratae has physiologically active effective ingredient.Wherein umbelliferone have significantly antibacterial, blood pressure lowering is calm, spasmolysis; Have and dispel the wind, antiinflammatory, pain relieving, to eliminate the phlegm and antitumor action, can the growth of anticancer, clinical in Therapeutic cancer, there is certain curative effect with breast carcinoma especially, also have certain effect to skin carcinoma, leukemia and what king's evil etc.To the special effect of gout acute attack.

Sanguis Draxonis: promoting blood circulation to remove blood stasis for oral administration, analgesic therapy, external hemostasia and promoting granulation, sore.Cure mainly: 1. congestion amenorrhea, dysmenorrhea, postpartum stagnation.2. lump in the abdomen mass in the abdomen, breast ventral spine pain.3. traumatic injury, congestion swells and ache.4. traumatic hemorrhage, ulcer being unable to heal.Select Liliaceae Dracaena cochinchinensis or dracaena cambodiana Pierre resin.

Herba Leonuri: acrid-sweet flavor, feeble QI temperature, nontoxic.Enter the heart, liver, urinary bladder channel.Invigorate blood circulation, blood stasis dispelling, regulating menstruation, disappear water.Control menoxenia, vaginal bleeding during pregnancy is had difficult labour, and retention of placenta, puerperal blood faints, abdominal pain due to blood stasis, metrorrhagia and metrostaxis, hematuria, rushes down blood, carbuncle skin infection.

Radix Notoginseng: the sweet mildly bitter flavor of Radix Notoginseng property, warm in nature, return liver, stomach through being used as medicine with root, root stock.Rare Chinese medicine, raw with can hemostasia and dissipation blood stasis, reducing swelling and alleviating pain, there is good hemostasia effect, significant hemopoietic function; Can tighten and improve Coronary microcirculation, Radix Notoginseng is used as medicine with a long history, acts on the peculiar treasured be considered as by ancient Chinese medicine doctor in medicine, therefore has the saying of " Radix Stephaniae Sinicae (Radix Stephaniae Dielsianae) "." taste is micro-sweet and bitter, quite like the taste of Radix Ginseng for Radix Notoginseng." " all canes flutter trauma, and the dripping person of blood stasis, chew namely stopping of rotten net for catching birds or fish immediately, namely bruise person dissipate.If during by cane, first take one, two money, then the blood not centre of punch, should take it after cane especially, puerperal, clothes were also good.On the whole this medicine temperature, sweet and slightly bitter taste, and sun is bright, the medicine of cloudy blood system of fainting, therefore all disorders of blood can be controlled "." book on Chinese herbal medicine is looked for the truth " is recorded: " Radix Notoginseng, common people only know function hemostasis and pain-relieving.Hardly realize that pain aches work because of blood stasis, because applying loose, blood stops blood.The bitter temperature of Radix Notoginseng abnormal smells from the patient, can in its blood stasis of blood systemization." Radix Notoginseng can increase coronary flow, decreased heart rate, reduces myocardial oxygen consumption, increases myocardium oxygen-resistant ability, improve microcirculation, removes the effect of smooth muscle spasm.

Radix Puerariae, sweet in the mouth, pungent, cool in nature.Enter spleen, stomach warp.There is yang invigorating expelling pathogenic factors from muscles, rash antidiarrheal, effect that relieving restlessness is only warm.For typhoid fever, warm headache stiffness of the nape, dysphoria with smothery sensation is quenched one's thirst, and has loose bowels, dysentery, and skin eruption is not saturating, hypertension, and angina pectoris is deaf.Be used for Hypertension neck pain, angina pectoris clinically, but also there is hypoglycemic activity.

Radix Morindae Officinalis, sweet, pungent, tepor.Return kidney, Liver Channel.Function cures mainly: kidney-replenishing, bone and muscle strengthening, wind-damp dispelling.For impotence and seminal emission, cold womb is infertile, menoxenia, and few abdomen cold type of pain, rheumatic arthralgia, muscles and bones flaccidity is soft.

Rhizoma Gastrodiae: property is flat.Taste, sweet.Master enters Liver Channel.This product endogenous wind stopping relieving convulsion, suppressing liver-YANG, dispelling wind and removing obstruction in the collateral.For controlling key medicine that is dizzy, headache; Again in numb limbs and tense tendons, hands and feet caused by paralysis, rheumatic arthralgia, the good merchantable brand of muscles and bones contracture.

Semen Sesami Nigrum: invigorating the liver and kidney, benefiting essence-blood, intestine moistening is dry.For dizziness and blurred vision, Hiccough and deaf, early whitening of beard and hair, post disease alopecia, dryness of the intestine constipation.

In Chinese medicine composition of the present invention, Radix Rhodiolae has QI invigorating lung heat clearing, Fructus Alpiniae Oxyphyllae is nourished heart, effect of hemostasis with astringents, dissipating blood stasis for subsidence of swelling, Rhizoma Polygoni Cuspidati expelling wind and removing dampness, dissipating blood stasis analgesic therapy, relieving cough and resolving phlegm, Placenta Hominis feels at ease to nourish blood, QI invigorating, benefit essence, removing toxic substances, be monarch drug altogether;

Radix Ginseng Rubra strongly invigorating primordial QI, multiple arteries and veins takes off admittedly, nourishing qi to stop, Herba Ecliptae liver and kidney tonifying, cooling blood for hemostasis, main deficiency of the liver and kindey, rubs Bai Ye for traumatic injury, bones and muscles pain due to rheumatism, Radix Paeoniae Alba nourishing blood to suppress the hyperactive liver, pain relieving in slow, yin fluid astringing receives antiperspirant, and Caulis Polygoni Multiflori is calmed the nerves, dredging collateral, dispels the wind, and is ministerial drug in side;

Assistant is with Radix seu Caulis Jasmini lanceolarii, Fructus Lycii, Caulis Spatholobi etc. for adjuvant drug, and wherein, Radix seu Caulis Jasmini lanceolarii cures mainly expelling wind and removing dampness, promoting blood circulation and stopping pain, dispelling the wind and dampness pathogens waist condyle pain, traumatic injury, sore, carbuncle; Fructus Lycii nourishing the liver, nourishing kidney; Caulis Spatholobi is enriched blood, and invigorates blood circulation, dredging collateral; Radix Gentianae Macrophyllae wind-damp dispelling, clearing away damp-heat, stopping numbness pain; Rhizoma Sparganii controls lump in the abdomen, gathers, distending pain over the hypochondrium, food stagnation distending pain, dysmenorrhea, amenorrhea, and postnatal blood stasis is suffered from abdominal pain, traumatic injury; Herba Saussureae Involueratae is dispeled the wind, antiinflammatory, pain relieving, eliminate the phlegm, pseudo-ginseng hemostatic blood stasis dispelling, reducing swelling and alleviating pain, Sanguis Draxonis promoting blood circulation to remove blood stasis, analgesic therapy, Radix Puerariae yang invigorating expelling pathogenic factors from muscles, rash antidiarrheal, relieving restlessness is temperature only, Rhizoma Gastrodiae endogenous wind stopping relieving convulsion, suppressing liver-YANG, dispelling wind and removing obstruction in the collateral, Herba Epimedii, pungent, sweet, warm, returning Liver and kidney warp, is all card common medicines of insufficiency of kidney-YANG, Semen Cuscutae the kidney invigorating and essence nourishing, nourishing the liver to improve visual acuity, Herba Cistanches kidney-replenishing, benefiting essence-blood, the Cortex Eucommiae, Herba Taxilli, Radix Polygoni Multiflori Preparata invigorating the liver and kidney, bone and muscle strengthening, antiabortive, Flos Carthami is invigorated blood circulation latus rectum, eliminating stasis to stop pain, Herba Agrimoniae astringing to arrest bleeding.

Herba Leonuri is invigorated blood circulation, blood stasis dispelling, regulating menstruation, and disappear water, Semen Sesami Nigrum invigorating the liver and kidney, benefiting essence-blood, and intestine moistening is dry, Radix Morindae Officinalis kidney-replenishing, bone and muscle strengthening, wind-damp dispelling, Fructus Ligustri Lucidi nourishing the liver and kidney, for making medicine.

Selected by Chinese medicine composition of the present invention, medical material compatibility is suitable, meet Chinese medicine and pharmacy and modern medicine theory, its compatibility meets Chinese medicine " monarch " principle, unique curative effect is had to postmenopausal osteoporosis, this medicine compatibility science, curative effect is rapid, the advantage that instant effect, short treating period, cure rate are high, expense is little.

Detailed description of the invention

For making the object of the embodiment of the present invention, technical scheme and advantage clearly, below in conjunction with embodiment, technical scheme of the present invention is clearly and completely described.Obviously, described embodiment is a part of the present invention, instead of whole embodiments.Based on described embodiments of the invention, the every other embodiment that those of ordinary skill in the art obtain under without the need to the prerequisite of creative work, all belongs to the scope of protection of the invention.Except as otherwise noted, the percent of the amount of alcohol in the present invention is percentage by volume, and v/v represents the volume ratio of solution.

Embodiment 1:

A kind of Chinese medicine composition preventing and treating postmenopausal osteoporosis of the present invention, get following traditional Chinese medicine raw medicine: the Radix Paeoniae Alba 12 grams, Herba Epimedii 16 grams, Fructus Ligustri Lucidi 3 grams, Semen Cuscutae 12 grams, Caulis Polygoni Multiflori 12 grams, Radix Ginseng Rubra 10 grams, 9 grams, Flos Carthami, Herba Ecliptae 15 grams, Radix Rhodiolae 15 grams, rub Bai Ye 8 grams, Herba Cistanches 5 grams, Fructus Lycii 3 grams, Caulis Spatholobi 14 grams, Radix seu Caulis Jasmini lanceolarii 9 grams, Herba Taxilli 6 grams, Radix Polygoni Multiflori Preparata 8 grams, Herba Saussureae Involueratae 5 grams, the Cortex Eucommiae 1 gram, Herba Agrimoniae 10 grams, Radix Notoginseng 5 grams, Rhizoma Polygoni Cuspidati 16 grams, Radix Gentianae Macrophyllae 10 grams, Placenta Hominis 8 grams, Rhizoma Sparganii 5 grams, Sanguis Draxonis 1 gram, Radix Puerariae 10 grams, Herba Leonuri 6 grams, Radix Morindae Officinalis 8 grams, 3 grams, Rhizoma Gastrodiae, Semen Sesami Nigrum 13 grams.

Embodiment 2:

A kind of Chinese medicine composition preventing and treating postmenopausal osteoporosis of the present invention, get following traditional Chinese medicine raw medicine: the Radix Paeoniae Alba 20 grams, Herba Epimedii 10 grams, Fructus Ligustri Lucidi 8 grams, Semen Cuscutae 5 grams, Caulis Polygoni Multiflori 17 grams, Radix Ginseng Rubra 12 grams, 4 grams, Flos Carthami, Herba Ecliptae 20 grams, Radix Rhodiolae 10 grams, rub Bai Ye 12 grams, Herba Cistanches 2 grams, Fructus Lycii 7 grams, Caulis Spatholobi 11 grams, Radix seu Caulis Jasmini lanceolarii 15 grams, Herba Taxilli 3 grams, Radix Polygoni Multiflori Preparata 13 grams, Herba Saussureae Involueratae 3 grams, the Cortex Eucommiae 3 grams, Herba Agrimoniae 5 grams, Radix Notoginseng 10 grams, Rhizoma Polygoni Cuspidati 13 grams, Radix Gentianae Macrophyllae 3 grams, Placenta Hominis 13 grams, Rhizoma Sparganii 3 grams, Sanguis Draxonis 3 grams, Radix Puerariae 5 grams, Herba Leonuri 4 grams, Radix Morindae Officinalis 10 grams, 4 grams, Rhizoma Gastrodiae, Semen Sesami Nigrum 16 grams.

Embodiment 3:

A kind of Chinese medicine composition preventing and treating postmenopausal osteoporosis of the present invention, get following traditional Chinese medicine raw medicine: the Radix Paeoniae Alba 13 grams, Herba Epimedii 11 grams, Fructus Ligustri Lucidi 4 grams, Semen Cuscutae 6 grams, Caulis Polygoni Multiflori 13 grams, Radix Ginseng Rubra 7 grams, 5 grams, Flos Carthami, Herba Ecliptae 18 grams, Radix Rhodiolae 11 grams, rub Bai Ye 9 grams, Herba Cistanches 4 grams, Fructus Lycii 6 grams, Caulis Spatholobi 12 grams, Radix seu Caulis Jasmini lanceolarii 13 grams, Herba Taxilli 4 grams, Radix Polygoni Multiflori Preparata 9 grams, Herba Saussureae Involueratae 4 grams, the Cortex Eucommiae 2 grams, Herba Agrimoniae 6 grams, Radix Notoginseng 6 grams, Rhizoma Polygoni Cuspidati 14 grams, Radix Gentianae Macrophyllae 5 grams, Placenta Hominis 10 grams, Rhizoma Sparganii 4 grams, Sanguis Draxonis 2 grams, Radix Puerariae 6 grams, Herba Leonuri 5 grams, Radix Morindae Officinalis 12 grams, 3 grams, Rhizoma Gastrodiae, Semen Sesami Nigrum 14 grams.

Embodiment 4:

A kind of Chinese medicine composition preventing and treating postmenopausal osteoporosis of the present invention, get following traditional Chinese medicine raw medicine: the Radix Paeoniae Alba 17 grams, Herba Epimedii 15 grams, Fructus Ligustri Lucidi 7 grams, Semen Cuscutae 11 grams, Caulis Polygoni Multiflori 16 grams, Radix Ginseng Rubra 8 grams, 8 grams, Flos Carthami, Herba Ecliptae 16 grams, Radix Rhodiolae 14 grams, rub Bai Ye 11 grams, Herba Cistanches 3 grams, Fructus Lycii 5 grams, Caulis Spatholobi 13 grams, Radix seu Caulis Jasmini lanceolarii 14 grams, Herba Taxilli 5 grams, Radix Polygoni Multiflori Preparata 12 grams, Herba Saussureae Involueratae 3 grams, the Cortex Eucommiae 1 gram, Herba Agrimoniae 10 grams, Radix Notoginseng 9 grams, Rhizoma Polygoni Cuspidati 13 grams, Radix Gentianae Macrophyllae 7 grams, Placenta Hominis 11 grams, Rhizoma Sparganii 3 grams, Sanguis Draxonis 1 gram, Radix Puerariae 10 grams, Herba Leonuri 4 grams, Radix Morindae Officinalis 11 grams, 4 grams, Rhizoma Gastrodiae, Semen Sesami Nigrum 15 grams.

Embodiment 5:

A kind of Chinese medicine composition preventing and treating postmenopausal osteoporosis of the present invention, get following traditional Chinese medicine raw medicine: the Radix Paeoniae Alba 15 grams, Herba Epimedii 12 grams, Fructus Ligustri Lucidi 5 grams, Semen Cuscutae 9 grams, Caulis Polygoni Multiflori 15 grams, Radix Ginseng Rubra 9 grams, 7 grams, Flos Carthami, Herba Ecliptae 19 grams, Radix Rhodiolae 13 grams, rub Bai Ye 10 grams, Herba Cistanches 4 grams, Fructus Lycii 4 grams, Caulis Spatholobi 11 grams, Radix seu Caulis Jasmini lanceolarii 11 grams, Herba Taxilli 5 grams, Radix Polygoni Multiflori Preparata 10 grams, Herba Saussureae Involueratae 5 grams, the Cortex Eucommiae 3 grams, Herba Agrimoniae 8 grams, Radix Notoginseng 8 grams, Rhizoma Polygoni Cuspidati 14 grams, Radix Gentianae Macrophyllae 9 grams, Placenta Hominis 12 grams, Rhizoma Sparganii 5 grams, Sanguis Draxonis 3 grams, Radix Puerariae 8 grams, Herba Leonuri 6 grams, Radix Morindae Officinalis 9 grams, 5 grams, Rhizoma Gastrodiae, Semen Sesami Nigrum 14 grams.

Embodiment 6:

A kind of Chinese medicine composition preventing and treating postmenopausal osteoporosis of the present invention, get following traditional Chinese medicine raw medicine: the Radix Paeoniae Alba 19 grams, Herba Epimedii 14 grams, Fructus Ligustri Lucidi 6 grams, Semen Cuscutae 7 grams, Caulis Polygoni Multiflori 14 grams, Radix Ginseng Rubra 9 grams, 6 grams, Flos Carthami, Herba Ecliptae 17 grams, Radix Rhodiolae 13 grams, rub Bai Ye 10 grams, Herba Cistanches 4 grams, Fructus Lycii 4 grams, Caulis Spatholobi 11 grams, Radix seu Caulis Jasmini lanceolarii 11 grams, Herba Taxilli 5 grams, Radix Polygoni Multiflori Preparata 10 grams, Herba Saussureae Involueratae 5 grams, the Cortex Eucommiae 3 grams, Herba Agrimoniae 8 grams, Radix Notoginseng 8 grams, Rhizoma Polygoni Cuspidati 14 grams, Radix Gentianae Macrophyllae 4 grams, Placenta Hominis 9 grams, Rhizoma Sparganii 5 grams, Sanguis Draxonis 3 grams, Radix Puerariae 8 grams, Herba Leonuri 3 grams, Radix Morindae Officinalis 8 grams, 5 grams, Rhizoma Gastrodiae, Semen Sesami Nigrum 16 grams.

Wherein, the preparation method of the described Chinese medicine composition of embodiment 1-6 is:

(1) each medical material of components by weight percent in the arbitrary described Chinese medicine composition of Example 1-6, be ground into coarse powder, the alcoholic solution that volumetric concentration is 70%-95% is doubly added according to the 4-10 of coarse powder gross weight, reflux, extract, three times, return time is 3-5h, filters, filtrate recycling ethanol, cold filtration, washes with water, obtains dry extract after drying;

(2) pulverized by dry extract obtained for step (1), add suitable amount of sucrose, dextrin mixing, take ethanol as wetting agent, granulate, dry, granulate, can obtain granule; Or the dry extract that step (1) is obtained dry, pulverize, and makes powder; Or dry extract obtained for step (1) is pulverized, adds appropriate micropowder silica gel, α-galactose mixing, take ethanol as wetting agent, granulate, dry, granulate, encapsulated, obtained capsule; Or dry extract obtained for step (1) is pulverized, adds suitable amount of sucrose, dextrin mixing, take ethanol as wetting agent, granulate, dry, granulate, tabletting, obtained tablet; Or to above-mentioned steps (1) obtain centrifugal after concentrated solution in add suitable amount of sucrose, essence mixing, sterilizing, fill, obtained medicinal liquid agent.

Acute toxicity test:

Get mice 60, body weight 22-25 gram, to mouse stomach capsule solution, test determination has been carried out to the median lethal dose(LD 50) (LD50) of administration, but has not measured LD50, because this has been mtd test.Result: with maximum dosage-feeding 120g/kg gavage, 280 times of the daily dosage of clinical plan that is equivalent to be grown up, in seven days mice none is dead, put to death each internal organs of mice anatomic observation and do not find toxic reaction, administration group and control group mice are without any difference.

Six months long term toxicity tests: get rat 60, body weight 180 ~ 220g, Experimental agents is set as high, medium and low three dosage, be respectively capsule 40g/kg, 20g/kg, 10g/kg, within dosage 1.1g/kg/ days, calculate with (75kg is standard) by people, be 40 times, 20 times and 10 times of people's effective dose; Separately establish a matched group, continuous gastric infusion 90 days, 180 days and Some Animals drug withdrawal, after 10 days, observe the impact on the every physiology of rat, biochemical indicator.Experimental result shows: by various dose to rat continuous oral 180 days, increases all without affecting the food-intake of rat and body weight.Overt toxicity effect is not all found to hepatic and renal function.Obvious impact is showed no on routine blood test, blood biochemistry, urine biochemistry and bone marrow sheet etc., between each group, compares no significant difference with matched group.

Clinical trial:

In order to verify the effect of Chinese medicine composition of the present invention, in November ,-2014 in January, 2013, outpatient service place random selecting patients with postmenopausal osteoporosis 200 example, at 60 ~ 82 years old age, average 66 ± 2.7 years old, be divided into experimental group and matched group, often organize 100 examples, 2 groups in age, menopause, height, body weight and bone density value etc. through statistical analysis, the equal not statistically significant of difference (P > 0.05), has comparability.

Diagnostic criteria:

According to the diagnostic criteria of " new Chinese medicine guideline of clinical investigations " standard envisages about primary osteoporosis:

(1) have general weakness osteodynia, be obvious mainly with low-back pain, increase the weight of gradually, can have scheuermann kyphosis deformity, microtrauma can cause fracture;

(2) x-ray performance: sclerotin is generally sparse, obvious with vertebra, pelvis, proximal femur.It is the most special that spinal column changes, and fish tail sample double concave can appear in vertebral body, and intervertebral space is broadening, has Schmorl tuberosity, and thoracic vertebra is Wedging, and vertebral body of getting involved is multiple, be dispersed in;

(3) the peak bone mass reduction of the more same sex of Dual X-ray inspection mensuration bone density, agnate health adult is more than or equal to 2.5 standard deviations.

The CM syndrome differentiation criterion of the traditional Chinese medical science:

(1) primary symptom: 1. lumbar vertebrae pain or whole body osteodynia; 2. soreness of the waist and knees.

(2) secondary disease: 1. vertebral body kowtows pain or tenderness; 2. can not be prudent; 3. lower limb are thin soft or numb; 4. vertigo and tinnitus; 5. body of the tongue is partially red or light; 6. deep-thready pulse or thin.

Possess 2 in primary symptom, 1. ~ 4. in item one in secondary disease.

Exclusion standard:

Get rid of important organ severe primary diseases such as merging the heart, brain, kidney and affect bone metabolic disease person, taking nearly half a year affects bone metabolism medicine person, merges fresh fracture person.

Therapeutic Method:

Experimental group and matched group are 12 weeks the course for the treatment of.

Treatment group: the tablet taking the Chinese medicine composition of the embodiment of the present invention 3, every day 3 times, the morning, noon and afternoon, respectively once each 3, every 7 days was a course for the treatment of.

Matched group: with salmon calcitonin injection (Beijing Shuanglu Pharmaceutical Co., Ltd., the accurate word H20020694 of traditional Chinese medicines), after skin test feminine gender, the 1st week: every day 1 time, each 50U, intramuscular injection; 2nd week: the next day 1 time, each 50U, intramuscular injection; 3rd ~ 12 weeks: 1 time weekly, each 50U, intramuscular injection.

Curative effect determinate standard:

According to " new Chinese medicine guideline of clinical investigations " standard envisages:

Recovery from illness: without pain, soreness of the waist and knees, flaccidity and weakness of the lower limbs is unable, and vertigo and tinnitus symptom is obviously improved, and bone density value improves more than 2%.

Effective: pain obviously alleviates, soreness of the waist and knees, flaccidity and weakness of the lower limbs is unable, vertigo and tinnitus symptom part is improved, and bone density value improves between (0 ~ 2) %.

Invalid: each side is all without improvement.Dual energy X ray absorptiometry is all adopted to measure the bone density (BMD) of lumbar vertebra and fl neck before and after all patient treatments.

Bone density criterion of therapeutical effect computational methods: (after treatment, T score value percentage ratio one treats front T score value percentage ratio) × 100%.

Result:

2 groups of Comparison of therapeutic: treatment group total effective rate is 96%, matched group total effective rate is 65%; 2 groups of comparing differences are obvious, have statistical significance (P < 0.05).

Clinical observation result is in table 1:

Group	Case	Cure	Effective	Effectively	Invalid	Total effective rate
							Matched group	100	25	29	11	35	65％
Treatment group	100	76	13	7	4	96％

Above result display, the cure rate for the treatment of group and total effective rate are apparently higher than matched group

BMD testing result contrast (gcm-2, x ± s) before and after the treatment of table 2:2 group

Clinical observation on the therapeutic effect result shows, Chinese medicine composition of the present invention has significant curative effect for control postmenopausal osteoporosis; Safety observations find, do not observe any clinical adverse, show Chinese medicine composition clinical practice of the present invention safely, have no side effect.

Last it is noted that above embodiment is only in order to illustrate technical scheme of the present invention, be not intended to limit; Although with reference to previous embodiment to invention has been detailed description, those of ordinary skill in the art is to be understood that: it still can be modified to the technical scheme described in foregoing embodiments, or carries out equivalent replacement to wherein portion of techniques feature; And these amendments or replacement, do not make the essence of appropriate technical solution depart from the scope of various embodiments of the present invention technical scheme.

Claims (10)

1. prevent and treat a Chinese medicine composition for postmenopausal osteoporosis, it is characterized in that: the crude drug of described Chinese medicine composition by the Radix Paeoniae Alba, Herba Epimedii, Fructus Ligustri Lucidi, Semen Cuscutae, Caulis Polygoni Multiflori, Rhizoma Polygoni Cuspidati, Radix Ginseng Rubra, Herba Ecliptae, Radix Rhodiolae, rub Bai Ye, Herba Cistanches, the Cortex Eucommiae, Fructus Lycii, Radix seu Caulis Jasmini lanceolarii, Caulis Spatholobi, Herba Taxilli, Radix Polygoni Multiflori Preparata, Herba Agrimoniae, Flos Carthami, Radix Gentianae Macrophyllae, Placenta Hominis, Rhizoma Sparganii, Herba Saussureae Involueratae, Sanguis Draxonis, Herba Leonuri, Radix Notoginseng, Radix Puerariae, Radix Morindae Officinalis, Rhizoma Gastrodiae, Semen Sesami Nigrum form.

2. the Chinese medicine composition of control postmenopausal osteoporosis according to claim 1, it is characterized in that: raw material composition and the parts by weight of making described Chinese medicine composition are: Radix Paeoniae Alba 12-20 part, Herba Epimedii 10-16 part, Fructus Ligustri Lucidi 3-8 part, Semen Cuscutae 5-12 part, Caulis Polygoni Multiflori 12-17 part, Radix Ginseng Rubra 7-12 part, Flos Carthami 4-9 part, Herba Ecliptae 15-20 part, Radix Rhodiolae 10-15 part, rub Bai Ye 8-12 part, Herba Cistanches 2-5 part, Fructus Lycii 3-7 part, Caulis Spatholobi 11-14 part, Radix seu Caulis Jasmini lanceolarii 9-15 part, Herba Taxilli 3-6 part, Radix Polygoni Multiflori Preparata 8-13 part, Herba Saussureae Involueratae 3-5 part, Cortex Eucommiae 1-3 part, Herba Agrimoniae 5-10 part, Radix Notoginseng 5-10 part, Rhizoma Polygoni Cuspidati 13-16 part, Radix Gentianae Macrophyllae 3-10 part, Placenta Hominis 8-13 part, Rhizoma Sparganii 3-5 part, Sanguis Draxonis 1-3 part, Radix Puerariae 5-10 part, Herba Leonuri 3-6 part, Radix Morindae Officinalis 8-13 part, Rhizoma Gastrodiae 3-5 part, Semen Sesami Nigrum 13-16 part.

3. the Chinese medicine composition of control postmenopausal osteoporosis according to claim 2, it is characterized in that: raw material composition and the parts by weight of making described Chinese medicine composition are: the Radix Paeoniae Alba 12 parts, Herba Epimedii 16 parts, Fructus Ligustri Lucidi 3 parts, Semen Cuscutae 12 parts, Caulis Polygoni Multiflori 12 parts, Radix Ginseng Rubra 10 parts, 9 parts, Flos Carthami, Herba Ecliptae 15 parts, Radix Rhodiolae 15 parts, rub Bai Ye 8 parts, Herba Cistanches 5 parts, Fructus Lycii 3 parts, Caulis Spatholobi 14 parts, Radix seu Caulis Jasmini lanceolarii 9 parts, Herba Taxilli 6 parts, Radix Polygoni Multiflori Preparata 8 parts, Herba Saussureae Involueratae 5 parts, the Cortex Eucommiae 1 part, Herba Agrimoniae 10 parts, Radix Notoginseng 5 parts, Rhizoma Polygoni Cuspidati 16 parts, Radix Gentianae Macrophyllae 10 parts, Placenta Hominis 8 parts, Rhizoma Sparganii 5 parts, Sanguis Draxonis 1 part, Radix Puerariae 10 parts, Herba Leonuri 6 parts, Radix Morindae Officinalis 8 parts, 3 parts, Rhizoma Gastrodiae, Semen Sesami Nigrum 13 parts.

4. the Chinese medicine composition of control postmenopausal osteoporosis according to claim 2, it is characterized in that: raw material composition and the parts by weight of making described Chinese medicine composition are: the Radix Paeoniae Alba 20 parts, Herba Epimedii 10 parts, Fructus Ligustri Lucidi 8 parts, Semen Cuscutae 5 parts, Caulis Polygoni Multiflori 17 parts, Radix Ginseng Rubra 12 parts, 4 parts, Flos Carthami, Herba Ecliptae 20 parts, Radix Rhodiolae 10 parts, rub Bai Ye 12 parts, Herba Cistanches 2 parts, Fructus Lycii 7 parts, Caulis Spatholobi 11 parts, Radix seu Caulis Jasmini lanceolarii 15 parts, Herba Taxilli 3 parts, Radix Polygoni Multiflori Preparata 13 parts, Herba Saussureae Involueratae 3 parts, the Cortex Eucommiae 3 parts, Herba Agrimoniae 5 parts, Radix Notoginseng 10 parts, Rhizoma Polygoni Cuspidati 13 parts, Radix Gentianae Macrophyllae 3 parts, Placenta Hominis 13 parts, Rhizoma Sparganii 3 parts, Sanguis Draxonis 3 parts, Radix Puerariae 5 parts, Herba Leonuri 4 parts, Radix Morindae Officinalis 10 parts, 4 parts, Rhizoma Gastrodiae, Semen Sesami Nigrum 16 parts.

5. the Chinese medicine composition of control postmenopausal osteoporosis according to claim 2, it is characterized in that: raw material composition and the parts by weight of making described Chinese medicine composition are: the Radix Paeoniae Alba 13 parts, Herba Epimedii 11 parts, Fructus Ligustri Lucidi 4 parts, Semen Cuscutae 6 parts, Caulis Polygoni Multiflori 13 parts, Radix Ginseng Rubra 7 parts, 5 parts, Flos Carthami, Herba Ecliptae 18 parts, Radix Rhodiolae 11 parts, rub Bai Ye 9 parts, Herba Cistanches 4 parts, Fructus Lycii 6 parts, Caulis Spatholobi 12 parts, Radix seu Caulis Jasmini lanceolarii 13 parts, Herba Taxilli 4 parts, Radix Polygoni Multiflori Preparata 9 parts, Herba Saussureae Involueratae 4 parts, the Cortex Eucommiae 2 parts, Herba Agrimoniae 6 parts, Radix Notoginseng 6 parts, Rhizoma Polygoni Cuspidati 14 parts, Radix Gentianae Macrophyllae 5 parts, Placenta Hominis 10 parts, Rhizoma Sparganii 4 parts, Sanguis Draxonis 2 parts, Radix Puerariae 6 parts, Herba Leonuri 5 parts, Radix Morindae Officinalis 12 parts, 3 parts, Rhizoma Gastrodiae, Semen Sesami Nigrum 14 parts.

6. the Chinese medicine composition of control postmenopausal osteoporosis according to claim 2, it is characterized in that: raw material composition and the parts by weight of making described Chinese medicine composition are: the Radix Paeoniae Alba 17 parts, Herba Epimedii 15 parts, Fructus Ligustri Lucidi 7 parts, Semen Cuscutae 11 parts, Caulis Polygoni Multiflori 16 parts, Radix Ginseng Rubra 8 parts, 8 parts, Flos Carthami, Herba Ecliptae 16 parts, Radix Rhodiolae 14 parts, rub Bai Ye 11 parts, Herba Cistanches 3 parts, Fructus Lycii 5 parts, Caulis Spatholobi 13 parts, Radix seu Caulis Jasmini lanceolarii 14 parts, Herba Taxilli 5 parts, Radix Polygoni Multiflori Preparata 12 parts, Herba Saussureae Involueratae 3 parts, the Cortex Eucommiae 1 part, Herba Agrimoniae 10 parts, Radix Notoginseng 9 parts, Rhizoma Polygoni Cuspidati 13 parts, Radix Gentianae Macrophyllae 7 parts, Placenta Hominis 11 parts, Rhizoma Sparganii 3 parts, Sanguis Draxonis 1 part, Radix Puerariae 10 parts, Herba Leonuri 4 parts, Radix Morindae Officinalis 11 parts, 4 parts, Rhizoma Gastrodiae, Semen Sesami Nigrum 15 parts.

7. the Chinese medicine composition of control postmenopausal osteoporosis according to claim 2, it is characterized in that: raw material composition and the parts by weight of making described Chinese medicine composition are: the Radix Paeoniae Alba 15 parts, Herba Epimedii 12 parts, Fructus Ligustri Lucidi 5 parts, Semen Cuscutae 9 parts, Caulis Polygoni Multiflori 15 parts, Radix Ginseng Rubra 9 parts, 7 parts, Flos Carthami, Herba Ecliptae 19 parts, Radix Rhodiolae 13 parts, rub Bai Ye 10 parts, Herba Cistanches 4 parts, Fructus Lycii 4 parts, Caulis Spatholobi 11 parts, Radix seu Caulis Jasmini lanceolarii 11 parts, Herba Taxilli 5 parts, Radix Polygoni Multiflori Preparata 10 parts, Herba Saussureae Involueratae 5 parts, the Cortex Eucommiae 3 parts, Herba Agrimoniae 8 parts, Radix Notoginseng 8 parts, Rhizoma Polygoni Cuspidati 14 parts, Radix Gentianae Macrophyllae 9 parts, Placenta Hominis 12 parts, Rhizoma Sparganii 5 parts, Sanguis Draxonis 3 parts, Radix Puerariae 8 parts, Herba Leonuri 6 parts, Radix Morindae Officinalis 9 parts, 5 parts, Rhizoma Gastrodiae, Semen Sesami Nigrum 14 parts.

8. the Chinese medicine composition of control postmenopausal osteoporosis according to claim 2, it is characterized in that: raw material composition and the parts by weight of making described Chinese medicine composition are: the Radix Paeoniae Alba 19 parts, Herba Epimedii 14 parts, Fructus Ligustri Lucidi 6 parts, Semen Cuscutae 7 parts, Caulis Polygoni Multiflori 14 parts, Radix Ginseng Rubra 9 parts, 6 parts, Flos Carthami, Herba Ecliptae 17 parts, Radix Rhodiolae 13 parts, rub Bai Ye 10 parts, Herba Cistanches 4 parts, Fructus Lycii 4 parts, Caulis Spatholobi 11 parts, Radix seu Caulis Jasmini lanceolarii 11 parts, Herba Taxilli 5 parts, Radix Polygoni Multiflori Preparata 10 parts, Herba Saussureae Involueratae 5 parts, the Cortex Eucommiae 3 parts, Herba Agrimoniae 8 parts, Radix Notoginseng 8 parts, Rhizoma Polygoni Cuspidati 14 parts, Radix Gentianae Macrophyllae 4 parts, Placenta Hominis 9 parts, Rhizoma Sparganii 5 parts, Sanguis Draxonis 3 parts, Radix Puerariae 8 parts, Herba Leonuri 3 parts, Radix Morindae Officinalis 8 parts, 5 parts, Rhizoma Gastrodiae, Semen Sesami Nigrum 16 parts.

9., according to the Chinese medicine composition of the arbitrary described control postmenopausal osteoporosis of claim 2-8, it is characterized in that, described Chinese medicine composition is prepared by the following method:

(1) each medical material of components by weight percent in the arbitrary described Chinese medicine composition of claim 2-8 is got, be ground into coarse powder, the alcoholic solution that volumetric concentration is 70%-95% is doubly added according to the 4-10 of coarse powder gross weight, reflux, extract, three times, return time is 3-5h, filters, filtrate recycling ethanol, cold filtration, washes with water, obtains dry extract after drying;

(2) pulverized by dry extract obtained for step (1), add suitable amount of sucrose, dextrin mixing, take ethanol as wetting agent, granulate, dry, granulate, can obtain granule; Or the dry extract that step (1) is obtained dry, pulverize, and makes powder; Or dry extract obtained for step (1) is pulverized, adds appropriate micropowder silica gel, α-galactose mixing, take ethanol as wetting agent, granulate, dry, granulate, encapsulated, obtained capsule; Or dry extract obtained for step (1) is pulverized, adds suitable amount of sucrose, dextrin mixing, take ethanol as wetting agent, granulate, dry, granulate, tabletting, obtained tablet; Or to above-mentioned steps (1) obtain centrifugal after concentrated solution in add suitable amount of sucrose, essence mixing, sterilizing, fill, obtained medicinal liquid agent.

10. the application of Chinese medicine composition in control postmenopausal osteoporosis medicine of the control postmenopausal osteoporosis as described in as arbitrary in claim 1-9.