CN103585414B - Pharmaceutical composition for treating sciatica and osteoporosis - Google Patents
Pharmaceutical composition for treating sciatica and osteoporosis Download PDFInfo
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Abstract
The invention discloses pharmaceutical composition for treating sciatica and osteoporosis, and belongs to the technical field of traditional Chinese medicine. The pharmaceutical composition comprises raw materials in parts by weight as follows: 8-20 parts of black false hellebore, 5-15 parts of ligusticum wallichii, 5-15 parts of radix paeoniae alba, 3-10 parts of lindley eupatorium, 10-25 parts of radix angelicae, 5-15 parts of herba sarcandrae, 10-20 parts of roots of bidentate achyranthes, 3-10 parts of underleaf pearl, 10-20 parts of Chinese thorowax root, 5-15 parts of roots of red-rooted salvia, 8-20 parts of poria cocos, 5-12 parts of radix rehmanniae praeparata, 10-20 parts of radix puerariae, 3-10 parts of asarum, 5-15 parts of mint, 3-10 parts of Siberian cocklebur, 3-10 parts of glossy privet fruit, 5-12 parts of herba epimedii, 10-15 parts of fruit of Chinese wolfberry, 10-20 parts of dogwood, 3-10 parts of radix sileris, 5-15 parts of seeds of Chinese dodder, 5-15 parts of bovine-derived powder, 5-25 parts of astragalus and 10-20 parts of liquorice. Pharmacology experiments and clinical experiments prove that the pharmaceutical composition has an obvious effect in treating the sciatica and the osteoporosis and wide medical popularization values.
Description
Technical field
The invention belongs to technical field of Chinese medicines, be specifically related to a kind ofly treat sciatica and the pharmaceutical composition of osteoporosis.
Background technology
Osteoporosis is common ailment of middle-aged and old, frequently-occurring disease, have a strong impact on the Health and Living quality of such crowd, osteoporosis and the fracture caused thereof occupy the 7th in current common disease, during serious threat, the health of old people, make it the public health problem becoming the whole world.At present, aged tendency of population is day by day serious, improves and has very important significance to the control consciousness of osteoporosis.Osteoporosis reduces (comprising the minimizing of bone mineral and substrate equal proportion) with bone amount, osseous tissue microstructure deteriorates to feature, show as trabecular bone structure to destroy, attenuate and rupture, and then cause the fragility of bone to increase, biomechanics of bone intensity declines, load holding capacity reduces, and is easy to a kind of systemic skeletal disease that capillary fracture or complete fracture occur.Patients with osteoporosis cardinal symptom is lumbar and back pain, hunchback, easily fractures clinically, and many with performance of suffering from a deficiency of the kidney, and as lumbar and back pain, hyposexuality etc., has had a strong impact on life and quality of life.According to the United Nations's statistics aging, oneself becomes 21st century irreversible worldwide trend, and China entered aging society in 1999.Chinese society's aging speed is faster than country's total population growth rate, according to incompletely statistics, the senile osteoporosis disease sickness rate of China more than 60 years old is about 59.89%, therefore increases bone density, and effectively treatment osteoporosis has become the important topic of people's extensive concern.
In the world's osteoporosis conference in 2004 of international osteoporosis foundation (IOF), Univ Sheffield UK's WHO metabolic osteopathy research center Johnell etc. analyzes 12 clinical researches, and 30,000 9 thousand people in 12 cohort studies are included in this research in.Find that bone density value is lower, the probability of happening of osteoporotic fracture and all kinds fracture is higher, and this situation rule in 65 years old age group is the most obvious.Bone density (BMD) full name is bone mineral density, is an important indicator of bone strength, and the intensity of osseous tissue has 75% ~ 85% relevant with bone density.The bone density of bone density phalanges unit are, refers to and the tightness degree that osseous tissue combines is often referred to bone mineral content.Bone density weighs an osteoporotic index objectively quantized at present, and be also an index of reflection bone amount, its unit is g/c ㎡, and bone density is higher, and sclerotin intensity is better.It is relevant to factors such as skeletal structure, bone amount, bone mineral contents.
Aging along with the age, the bone density of each skeleton in the whole body is all in downward trend gradually, and bone density drops to a certain degree, is easy to fracture.The mechanism that bone density declines is that bone metabolism is unbalance, and people's bone metabolism before 35 years old is vigorous, and the calcium of absorption absorbs to enter in skeleton very soon and precipitates, and rapidly, now bone is the strongst in bone growth regeneration.Due to effect osteoblastic in skeleton, bone formation is greater than bone loss during this period.Women 35 years old, male are after 40 years old, and because gastrointestinal function weakens, osteotrophy absorbs and reduces and loss increase, bone formation and osteoclasia disequilibrium, and in performance bone structure, bone trabecula destroys, and attenuate, rupture, gap becomes greatly, hollow.If osteoporosis is treated not in time or be can not get effective treatment usually can cause Secondary Sciatic Pain.
Sciatica refers to the pain of sciatic nerve path and distribution thereof, namely on rear side of buttocks thigh, after shank outside and foot outside pain.If pain recurrent exerbation, with the passing of time there will be the atrophy of Ipsilateral lower limb muscles, or occur walking lamely.Sciatica is not independently disease, but the syndrome caused by various diseases.In China, primary sciatica is very rare, only accounts for 1%, has the sciatica of more than 98% to be caused by spinal lesion in addition.Cause the disease of Secondary Sciatic Pain more clinically, common mainly contains following disease or symptom: (1) causes sciatica of nerve roots disease the most common to be prolapse of lumbar intervertebral disc, also has lumbar spinal stenosis and intervertebral foramina stenosis and lumbosacral spine hyperplastic spondylitis in addition; (2) congenital malformation is also comparatively common reason, as abnormal in spina bifida occulta, lumbar sacralization, disordered small joint and processus transversus vertebrarum etc.; (3) soft tissue diseases is injured outside, as inflammation knitted by lumbosacral region fracture, hypertrophy of ligamentum flavum, muscle fiber; (4) osteoarticular inflammation and infection, as ankylosing spondylitis, spondylocace, suppurative spondylitis; (5) some other disease, as osteoporosis, subarachnoid hemorrhage, angiopathy etc.
The difference of producing cause and the mechanism of action is lacked according to bone density, diverse ways can be selected to increase bone density, current clinical treatment many employings calcium preparation, activated vitamin D, gonadal hormone, calcitonin, diphosphonate and fluoride etc., though there is certain curative effect, but side effect is large, somewhat expensive, and cure the symptoms, not the disease.In treatment, western medicine still lacks effective measures, and medicinal application is also very limited.Simple replenishing the calcium only can delay but can not stop the loss of bone amount, therefore a kind of efficient supplementing of research and development is run off calcareous and can consolidate and prevent bone amount to run off and safe without toxic side effect, thus fundamentally solves osteoporotic medicine and become the problem urgently needing to solve.
Chinese medicine is of long standing and well established, and it have accumulated abundant clinical practice and theory of Chinese medical science in treatment osteoporosis and its Secondary Sciatic Pain caused, and as being instruct with theory of Chinese medical science, then has kidney invigorating and YANG supporting, replenishing QI to invigorate the spleen, methods such as adjusting liver of invigorating blood circulation.The traditional Chinese medical science thinks that bone density decline cause has two, and one is deficiency of kidney-essence, has saying of " kidney governing bones, raw marrow fill brain, its Hua Fa " in tcm theory, thus deficiency of kidney-essence then muscles and bones is unable; Two is spleen deficiency of kidney-QI, the merit then deficiency of kidney-essence of insufficiency of the spleen mistake transporting, and skeleton loses supports, so fragile unable.
In prior art, chemicals is cured the symptoms, not the disease, and easily produces hormonal medicaments toleration, and poisonous side effect of medicine is large, and it is fixed that Chinese medicine then exists uncertain therapeutic efficacy, lacks relative medicine preparation.In order to overcome above-mentioned the deficiencies in the prior art, the object of this invention is to provide a kind of effectively can treat osteoporosis and sciatica and instant effect, short treating period, Chinese medicine that cure rate is high.
For realizing object of the present invention, now according to following technical scheme, Chinese medicine composition of the present invention is made up of the raw material of following weight portion: Rhizoma et radix veratri (Radix Rhizoma Veratri) 8-20 part, Rhizoma Chuanxiong 5-15 part, Radix Paeoniae Alba 5-15 part, Herba Eupatorii Lindleyani 3-10 part, Radix Angelicae Dahuricae 10-25 part, Herba Sarcandrae 5-15 part, Radix Achyranthis Bidentatae 10-20 part, Herba Phyllanthi Urinariae 3-10 part, Radix Bupleuri 10-20 part, Radix Salviae Miltiorrhizae 5-15 part, Poria 8-20 part, Radix Rehmanniae Preparata 5-12 part, Radix Puerariae 10-20 part, Herba Asari 3-10 part, Herba Menthae 5-15 part, Herba Xanthii 3-10 part, Fructus Ligustri Lucidi 3-10 part, Herba Epimedii 5-12 part, Fructus Lycii 10-15 part, Fructus Corni 10-20 part, Radix Saposhnikoviae 3-10 part, Semen Cuscutae 5-15 part, Os Bovis seu Bubali powder 5-15 part, Radix Astragali 5-25 part, Radix Glycyrrhizae 10-20 part.
According to Chinese medicine composition to osteoporosis and the difference of sciatica therapeutic effect, above-mentioned Chinese medicine composition basis is preferably as follows:
(1) Rhizoma et radix veratri (Radix Rhizoma Veratri) 15 parts, Rhizoma Chuanxiong 10 parts, the Radix Paeoniae Alba 10 parts, Herba Eupatorii Lindleyani 7 parts, the Radix Angelicae Dahuricae 18 parts, Herba Sarcandrae 10 parts, Radix Achyranthis Bidentatae 15 parts, Herba Phyllanthi Urinariae 7 parts, Radix Bupleuri 15 parts, Radix Salviae Miltiorrhizae 10 parts, 14 parts, Poria, 9 parts, Radix Rehmanniae Preparata, Radix Puerariae 15 parts, Herba Asari 7 parts, Herba Menthae 10 parts, Herba Xanthii 7 parts, Fructus Ligustri Lucidi 6 parts, Herba Epimedii 8 parts, Fructus Lycii 13 parts, Fructus Corni 15 parts, Radix Saposhnikoviae 7 parts, Semen Cuscutae 10 parts, Os Bovis seu Bubali powder 10 parts, the Radix Astragali 20 parts, 15 parts, Radix Glycyrrhizae.
(2) Rhizoma et radix veratri (Radix Rhizoma Veratri) 8 parts, Rhizoma Chuanxiong 5 parts, the Radix Paeoniae Alba 5 parts, Herba Eupatorii Lindleyani 3 parts, the Radix Angelicae Dahuricae 10 parts, Herba Sarcandrae 5 parts, Radix Achyranthis Bidentatae 10 parts, Herba Phyllanthi Urinariae 3 parts, Radix Bupleuri 10 parts, Radix Salviae Miltiorrhizae 5 parts, 8 parts, Poria, 5 parts, Radix Rehmanniae Preparata, Radix Puerariae 10 parts, Herba Asari 3 parts, Herba Menthae 5 parts, Herba Xanthii 3 parts, Fructus Ligustri Lucidi 3 parts, Herba Epimedii 5 parts, Fructus Lycii 10 parts, Fructus Corni 10 parts, Radix Saposhnikoviae 3 parts, Semen Cuscutae 5 parts, Os Bovis seu Bubali powder 5 parts, the Radix Astragali 5 parts, 10 parts, Radix Glycyrrhizae.
(3) Rhizoma et radix veratri (Radix Rhizoma Veratri) 20 parts, Rhizoma Chuanxiong 15 parts, the Radix Paeoniae Alba 15 parts, Herba Eupatorii Lindleyani 10 parts, the Radix Angelicae Dahuricae 25 parts, Herba Sarcandrae 15 parts, Radix Achyranthis Bidentatae 20 parts, Herba Phyllanthi Urinariae 10 parts, Radix Bupleuri 20 parts, Radix Salviae Miltiorrhizae 15 parts, 20 parts, Poria, 12 parts, Radix Rehmanniae Preparata, Radix Puerariae 20 parts, Herba Asari 10 parts, Herba Menthae 15 parts, Herba Xanthii 10 parts, Fructus Ligustri Lucidi 10 parts, Herba Epimedii 12 parts, Fructus Lycii 15 parts, Fructus Corni 20 parts, Radix Saposhnikoviae 10 parts, Semen Cuscutae 15 parts, Os Bovis seu Bubali powder 15 parts, the Radix Astragali 25 parts, 20 parts, Radix Glycyrrhizae.
(4) Rhizoma et radix veratri (Radix Rhizoma Veratri) 12 parts, Rhizoma Chuanxiong 12 parts, the Radix Paeoniae Alba 10 parts, Herba Eupatorii Lindleyani 5 parts, the Radix Angelicae Dahuricae 16 parts, Herba Sarcandrae 11 parts, Radix Achyranthis Bidentatae 13 parts, Herba Phyllanthi Urinariae 6 parts, Radix Bupleuri 20 parts, Radix Salviae Miltiorrhizae 10 parts, 10 parts, Poria, 8 parts, Radix Rehmanniae Preparata, Radix Puerariae 16 parts, Herba Asari 6 parts, Herba Menthae 10 parts, Herba Xanthii 5 parts, Fructus Ligustri Lucidi 8 parts, Herba Epimedii 7 parts, Fructus Lycii 10 parts, Fructus Corni 14 parts, Radix Saposhnikoviae 10 parts, Semen Cuscutae 5 parts, Os Bovis seu Bubali powder 15 parts, the Radix Astragali 15 parts, 17 parts, Radix Glycyrrhizae.
In order to express Chinese medicine composition of the present invention better, Chinese medicine composition of the present invention can be prepared into dosage form conventional clinically.Such as, the preparations such as powderous preparations, powder, pill, sublimed preparation, unguentum, granule, oral liquid, syrup, tablet, capsule, described pharmaceutical preparation all can prepare according to Chinese medicine preparation preparation method well-known to those skilled in the art.Preferably, Chinese medicine composition of the present invention conveniently preparation technology be prepared into powder, water preparation, tablet or capsule.
Present invention also offers a kind of preparation method of above-mentioned Chinese medicine composition, it mainly comprises following step: get above-mentioned Chinese crude drug by weight and be broken into coarse powder, the alcoholic solution that volumetric concentration is 40% ~ 95% is added according to 4 ~ 9 times of coarse powder gross weight, reflux, extract, three times, return time is 2 ~ 5h, filters, filtrate recycling ethanol, cold filtration, washes with water, namely obtains Chinese medical concrete after drying; Those skilled in the art can technically prepare conventional Chinese medicine pharmaceutical dosage form clinically, as tablet, capsule etc. in this preparation method.
According to Chinese medicine Historical Data Data About, the pharmacologically active of above-mentioned Chinese crude drug is as follows:
Rhizoma et radix veratri (Radix Rhizoma Veratri) is used for the treatment of the diseases such as the heap soil or fertilizer over and around the roots of middle wind-phlegm, epilepsy, lymphangitis, malaria, mastitis, fracture, traumatic injury, tinea capitis, scabies, also can be used for going out maggot, fly etc.; It can promote union of fracture, thus shortens healing time, and especially outstanding with fracture of shaft of femur, the average clinical healing date is 37 days, but healing time length and classification of fracture and manual reduction technology have obvious relation;
Rhizoma Chuanxiong, original name rhizome of chuanxiong Qiong; A kind of Chinese medicinal plant, is usually used in blood-activating and qi-promoting, wind-expelling pain-stopping, cures mainly menoxenia, dysmenorrhea, amenorrhea, difficult labour, retention of placenta, and lochia is suffered from abdominal pain, lump, heart pain in chest and hypochondrium, and traumatic injury swells and ache, headache vertigo and head dark, anemofrigid-damp arthralgia, numb limbs and tense tendons, ulcer sores; Blood circulation promoting and blood stasis dispelling effect is extensive, the suitable various disease of stagnation of blood stasis; Wind-expelling pain-stopping, effectiveness is excellent, can control the diseases such as wind syndrome of head headache, rheumatic arthralgia; It is gas medicine in blood that former times people calls Rhizoma Chuanxiong, the functions such as pungent loose, the resolving depression of its residence of dangerous speech, sensible, pain relieving;
The Radix Paeoniae Alba is cool in nature, and bitter in the mouth acid, is slightly cold, has easing the affected liver of enriching blood, suppressing the hyperactive liver pain relieving.Yin fluid astringing receives the effects such as antiperspirant, is applicable to fever due to yin deficiency, menoxenia, the breast abdomen pain over the hypochondriac region, extremity contraction suddenly, dysentery stomachache, spontaneous sweating, metrorrhagia, the inferior disease of band; Its paeoniflorin contained has antibacterial, antipyretic, antiinflammatory, increase coronary flow, improves the effect of myocardial nutritional flow, blood vessel dilating, antagonism acute myocardial ischemia, anticoagulant, calmness, analgesia, spasmolytic, antiulcer, adjustment blood glucose;
The white drum nail of Herba Eupatorii Lindleyani another name, relieving dyspepsia grass, hair Herba Lycopi, bitter in the mouth, property is put down; Cure mainly: don't lung cough-relieving, resolving phlegm and relieving asthma, blood pressure lowering;
Radix Angelicae Dahuricae expelling wind and cold, understand things pain-stopping, evacuation of pus of invigorating blood circulation, granulation promoting pain relieving, dampness leukorrhagia stopping; For mastalgia, swell and ache, have a headache, have a toothache, nasal sinusitis, hemorrhoidal hamorrhage anal fistula, leucorrhea with red and white discharge, ulcer sores, skin pruritus; Modern pharmacological research proves that the Radix Angelicae Dahuricae also has antiinflammatory, antipyretic-antalgic, active eliminating stagnation, can be used for controlling the effects such as mammary gland caking with other Chinese Medicine and Clavicular;
Herba Sarcandrae, function cures mainly: anti-inflammation, dispelling wind and removing obstruction in the collateral, blood circulation promoting and dispersing pathogen accumulation; For pneumonia, appendicitis, cellulitis, rheumatic arthralgia, injury from falling down, tumor; Treat rheumatoid arthritis in addition, 4 examples on probation, each intramuscular injection 4ml (every ml is containing crude drug 2 grams), every day 3 times, continuous 1-2 week; Preliminary observation, has certain short term effect;
Radix Achyranthis Bidentatae, invigorating the liver and kidney, bone and muscle strengthening, eliminating blood stasis and inducing menstruation, conducting blood to flow downwards; For soreness of waist and knee joint, muscles and bones is unable, amenorrhea lump in the abdomen, dizziness due to hyperactivity of liver-YANG; The traditional Chinese medical science is thought, its property bitter but sweet flavor acid is flat, has promoting blood circulation to restore menstrual flow, invigorating the liver and kidney, bone and muscle strengthening, inducing diuresis for treating stranguria syndrome, draws effect that blood (fire) is descending, be usually used in the gynaecopathia such as amenorrhea, dysmenorrhea, menoxenia, puerperal abdonimal pain for the treatment of stagnation of blood stasis, traumatic injury, the soreness of waist and knee joint of suffering from a deficiency of the kidney, weakness of the lower extremities, hematuria; dysuria, the diseases such as the headache that Urethra astringent pain and burning hot upper inflammation cause, dizzy, haematemesis, epistaxis;
Herba Phyllanthi Urinariae, micro-hardship, sweet, cool; Function cures mainly: clearing away heat and promoting diuresis, improving eyesight, removing food stagnancy; For oedema due to nephritis, urinary system infection, calculus, enteritis, dysentery, infantile malnutrition, eye keratitis, icterohepatitis, external is controlled Trimeresurus stejnegeri and is bitten;
Radix Bupleuri, cold nature, bitter in the mouth, pungent, return Liver Channel, gallbladder meridian, tool depressed liver-energy dispersing and function of gallbladder promoting, dredge gas resolving depression, loose effect of fire; Radix Bupleuri (processed with vinegar), bitter in the mouth, cold nature, returns liver, gallbladder meridian; Processed with vinegar can relax and rise loose property, strengthens dispersing the depressed liver-QI for alleviating pain effect, is applicable to the hypochondriac pain of stagnation of QI due to depression of the liver, stomachache and menoxenia, and normal being equal to Fructus Aurantii, Rhizoma Cyperi, Rhizoma Chuanxiong is used; Sanguis Trionycis Radix Bupleuri is bitter, is slightly cold, returns liver, gallbladder meridian.Sanguis Trionycis is processed and can be suppressed to rise floating property, and enhancing liver heat removing is brought down a fever, preventing the attack (or recurrence) of malaria effect; Often be equal to use with Herba Artemisiae Annuae, Cortex Lycii, the Radix Paeoniae Alba, Gypsum Fibrosum, the Rhizoma Anemarrhenae, strengthen the effect of the exterior and the interior reducing the asthenic fever;
Radix Salviae Miltiorrhizae, there is promoting blood circulation to remove blood stasis, detumescence hemostasis, anti-inflammatory analgetic, menstruction regulating and pain relieving, coronary artery dilator, improve myocardial ischemia situation, reduce blood pressure, calm the nerves with all worries set aside, blood sugar lowering and the effect such as antibacterial, to menoxenia, amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia; Hepatosplenomegaly, the diseases such as angina pectoris have certain curative effect; In addition, modern medicine experiment proves, Radix Salviae Miltiorrhizae also has anti-platelet aggregation, reduces the function of blood viscosity and the inside and outside blood coagulation system of adjustment, is the natural Chinese medicine that a kind of safety treats again cardiovascular disease reliably; Radix Salviae Miltiorrhizae Tabellae is the Chinese patent medicine of blood circulation promoting and blood stasis dispelling, regulating QI to relieve pain; The disease such as be mainly used in angina pectoris, hypertension, cervical spondylosis and feel oppressed in the heart; And the side effect that is reliable, Radix Salviae Miltiorrhizae Tabellae of its drug effect is little;
Poria sweet in the mouth, light, property are put down, and are used as medicine and have the function of promoting diuresis to eliminate damp pathogen, strengthening the spleen stomach function regulating, mind tranquilizing and the heart calming; Modern medicine study: Poria energy enhancing human body immunity function, pachyman has obvious antitumor and protects the liver dirty effect; Dysuria, edema distension, phlegm retention cough with dyspnea, vomiting, malignant histocytosis can be controlled, have loose bowels, pass out semen, stranguria with turbid discharge, palpitation with fear, the disease such as forgetful; Contained pachymic acid has the effect of enhancing immunity, antitumor and calmness, blood sugar lowering etc.; Can be relaxed gastrointestinal smooth muscle, the effects such as gastric acid secretion inhibiting, prevents hepatic necrosis, antibacterial;
Radix Rehmanniae Preparata, vital essence replenishing and marrow benifiting, bone and muscle strengthening, " detailed outline ": " fill out bone marrow, longue meat, promoting generation of vital essence and blood, tonifying five ZANG-organs internal injury is not enough, promoting blood circulation, sharp knowledge, black beard and hair, man's five kinds of strain and seven kinds of impairment, woman's damaging the spleen and stomach threatened abortion, irregular menorrhea, and tire produces all kinds of diseases and ailments; " it is on the impact of medulla hematopoietic system: Radix Rehmanniae Preparata water decoction gavages every 0.5g to posthemorrhagic anemia mice; every day 1 time; continuous 10 days; can promote the recovery of anemia animal erythrocyte, hemoglobin, accelerates propagation, the differentiation of pluripotential hemopoietic stem cell (CFU-S), bone marrow hemopoietic progenitor cell of red blood cell line (CFU-E);
Radix Puerariae, sweet in the mouth is micro-pungent, gas delicate fragrance, cool in nature; Function cures mainly: yang invigorating expelling pathogenic factors from muscles, rash antidiarrheal, and relieving restlessness is temperature only; Cure the wound cold, warm headache stiffness of the nape, and dysphoria with smothery sensation is quenched one's thirst, and has loose bowels, dysentery, and skin eruption is saturating, hypertension, angina pectoris, deaf, diarrhea due to hypofunction of the spleen, the disease such as cure mainly that fever caused by exogenous pathogens, head and neck pain are strong, measles sends out smooth, epidemic febrile disease is thirsty, quench one's thirst, alcoholism, obstruction of qi in the chest and cardialgia thoroughly;
Herba Asari, dispels the wind, cold expelling, and row water, has one's ideas straightened out; Control air-cooled headache, nasal sinusitis, toothache, phlegm retention cough with dyspnea, rheumatic arthralgia; Herba Asari volatile oil has obvious central inhibitory action, can calm, analgesia and antipyretic; The higenamine be separated from Herba Asari has the extensive physiological action of adrenergic beta-agonist sample, thus has the effects such as heart tonifying, blood vessel dilating, relaxing smooth muscle, enhancing lipid metabolism and raise blood sugar;
Herba Menthae is cool in nature, and sweet in the mouth is pungent, is a kind of conventional Chinese medicine, is widely used; Cure mainly dispelling wind, dispel the heat, ward off dirty, removing toxic substances, affection due to external wind and heat, headache, laryngopharynx swelling and pain, dyspepsia flatulence, aphtha, toothache, skin ulcer scabies, urticaria, epidemic febrile disease from the beginning of, rubella pruritus, stagnation of QI due to depression of the liver, hypochondriac pain uncomfortable in chest;
Herba Xanthii, toil, cold, poisonous; Cure mainly flu, wind syndrome of head, dizziness, nasal sinusitis, conjunctival congestion, corneal nebula, pathogenic wind-warm arthralgia pain, contracture numbness, wind leprosy, furuncle, scabies, skin pruritus, hemorrhoid, dysentery, wind and heat eliminating, removing toxic substances parasite killing, arthralgia chiefly caused by damp pathogen contracture, loose wind dehumidifying, understand things pain-stopping;
Fructus Ligustri Lucidi, has another name called Fructus Ligustri Lucidi, Fructus Ligustri Lucidi is real, and property is put down, bitter in the mouth, sweet, and effect of tool replenishing kidney-YIN, nourishing the liver to improve visual acuity, belongs to nourishing YIN class medicine in Chinese medicine; Cure mainly Light-headedness, soreness of the waist and knees, tinnitus, early whitening of beard and hair, osteopyrexia and fever, poor vision;
Herba Epimedii, acrid, sweet, warm; Cure mainly kidney-replenishing, bone and muscle strengthening, wind-damp dispelling, dyspnea and cough due to deficiency of the kidney, soreness of the waist and knees, rheumatic arthralgia, hemiplegia, extremity are meciless;
Fructus Lycii, the flat effect with the liver and the kidney tonifying of sweet in the mouth, property, says in Compendium of Material Medica and " takes hard muscles and bones for a long time, make light of one's life by commiting suicide not old, resistance to cold and summer-heat; " traditional Chinese medical science commonly use it treating hepatic and renal YIN deficiency, soreness of the waist and knees, dizziness, forgetful, dizzy, the many tear of blurred vision, quench one's thirst, the disease such as seminal emission; Modern pharmacology research confirms Fructus Lycii scalable body's immunity, can effectively grow and cell mutation, have the effect of the aspect such as slow down aging, anti-fatty liver, adjusting blood lipid and blood glucose, promotion hemopoietic function by Tumor suppression, and is applied to clinical;
Fructus Corni, Compendium of Material Medica is carried: " Fructus Corni, cure mainly pathogen cold and heat under the heart, warming middle-JIAO, by cold temperature numbness, goes three worms, and clothes are made light of one's life by commiting suicide for a long time; There is the merit of reinforcing YIN-essence benefit essence, settling five organs, logical nine orifices, only dribbling urination; Take improving eyesight, brute force for a long time all the year round "; Its sour in the mouth, adstringency, tepor; Return liver, kidney channel.Liver and kidney tonifying, essence astringing and desertion stemming; For vertigo and tinnitus, soreness of waist and knee joint;
Radix Saposhnikoviae, acrid in the mouth, sweet, slightly warm in nature.Effect: expelling pathogenic wind from the body surface, removing dampness to relieve pain, spasmolytic, antipruritic; Cure mainly affection of exogenous wind-cold, headache general pain, rheumatic arthralgia, joint is ached, stomachache is had loose bowels, discharging fresh blood stool, tetanus, rubella pruritus, skin infection from the beginning of; " Bencao Jingshu " is recorded: " it is general that Radix Saposhnikoviae controls wind, rises and send out and can fall apart, thus main large dizziness due to wind pain, aversion to wind ailment said due to cold or exposure, whole body arthralgia numbness, hypochondriac pain, side of body public attention face go, and extremity contraction is anxious ";
Semen Cuscutae is acrid in the mouth, sweet, flat, nontoxic; Cure mainly the kidney invigorating and essence nourishing, nourishing the liver to improve visual acuity; The waist knee joint muscles and bones being applicable to deficiency of the liver and kindey is ached, the diseases such as legs and feet weakness, dizziness and blurred vision, blurring of vision, Hiccough and deaf;
The Radix Astragali, sweet in the mouth, slightly warm in nature, returns liver, spleen, lung, kidney channel; There is effect that benefiting QI for strengthening the superficies, arresting sweating are admittedly de-, hold in the palm skin ulcer granulation promoting, inducing diuresis to remove edema; In traditional Chinese medical science Five elements theory, what spring was corresponding is liver, and therefore, it is most important for the health preserving in spring to take good care of irritability; Osteoporosis, lumbar spondylosis, cervical spondylosis, anemia etc., the disease persons such as visible joint pain, numb spontaneous perspiration, available Huangqi Guizhi Wuwu Tang;
Radix Glycyrrhizae, sweet in the mouth, property is put down, nontoxic; Treating disorders in five ZANG-organs six internal organs cold and heat pathogen, hard muscles and bones, longue meat, times strength, removing toxic substances, clothes are made light of one's life by commiting suicide and are prolonged life for a long time; Raw by pathogenic fire purging heat, ripe use is fallen apart exterior cold, goes pharyngalgia, except pathogenic heat, and slow healthy energy, yin nourishing blood, tonifying the spleen and stomach, lung moistening; Eliminate the phlegm, pain relieving, spasmolytic is so that the pharmacological action such as anticancer; In the traditional Chinese medical science, Radix Glycyrrhizae invigorating the spleen and replenishing QI, relieving cough and moistening lung, emergency is detoxified, and is in harmonious proportion hundred medicines.Clinical practice divides, and " life is used " is not with " processed with honey "; Raw with curing mainly laryngopharynx swelling and pain, cellulitis skin infection, gastrointestinal ulceration and solution poison of drug, alimentary toxicosis etc.; Processed with honey cures mainly spleen and stomach function and goes down, and large loose stool is thin, weak heating and cough, cardiopalmus.
The present invention also asks to protect above-mentioned Chinese medicine composition in preparation treatment osteoporosis and purposes in sciatica medicine.Pharmaceutical composition of the present invention treat osteoporosis and sciatica time, demonstrate remarkable anti-inflammatory and antalgic and significantly can increase the activity of bone density.Test examples 7 of the present invention shows, give positive drug and Chinese medicine composition of the present invention all can obtain significant antiphlogistic effects, wherein the antiphlogistic effects of Chinese medicine composition high dose group of the present invention and positive controls have pole significant difference, Chinese medicine composition low dose group and positive controls have significant difference, and this shows that the high dose group of Chinese medicine composition of the present invention and the antiphlogistic effects of low dose group significantly will be better than positive controls.Test examples 8 mice of the present invention licks foot response latency time showing, compare with model group, after administration after 1h and 2h, the incubation period that the mice of each administration group of Chinese medicine composition of the present invention adds foot reaction is all greater than model group, there is dose-dependence, and be significantly greater than the incubation period of high dose group model group (
p< 0.05).What illustrate that this Chinese medicine composition of the present invention can extend that mice stimulates hot plate adds the sufficient response latency, has certain analgesic activity.Under same experiment condition, positive control drug cydiodine group (
p< 0.05) and Huanglianshangqing Tablet group (1h,
p< 0.05; 2h,
p< 0.01) also extend the incubation period that mice adds foot reaction, there is certain analgesic activity, but its analgesic effect and model group there was no significant difference.The embodiment of the present invention 9 shows, and model group compares with blank group, and the BMD of left tibia, right tibia, lower neck bone and lumbar vertebra all has significant difference, shows that the bone mineral content that retinoic acid causes osteoporosis rat obviously declines.Compare with model group, QIANGGU JIAONANG group and Chinese medicine composition of the present invention are respectively organized and all can be raised rat bone mineral content.Wherein low, high, the middle dosage group of Chinese medicine composition of the present invention compares with model group, significantly improve the BMD of model mouse left tibia, right tibia, lower neck bone and lumbar vertebra, show that the Chinese medicine composition of doses obviously can increase the bone mineral content content that retinoic acid causes osteoporosis model, and high, middle dosage group has significance compared with QIANGGU JIAONANG group to the bone mineral content content of osteoporosis model difference.
In a word, Chinese medicine composition of the present invention is being treated osteoporosis and in sciatica, is compared with prior art having following advantage:
(1) compared with current chemotherapeutic agent, Chinese medicine composition of the present invention is natural pure Chinese medicinal preparation, untoward reaction and side effect significantly reduce, and Chinese medicine composition effect of the present invention is comprehensive, medication effect is better, significantly improve osteoporosis and the compliance of sciatica patient, and improve the quality of life of patient.
(2) multi-medicament component is contained in Chinese medicine composition of the present invention, action target spot is numerous, pharmacological evaluation shows it and has significant blood circulation promoting and blood stasis dispelling, anti-inflammatory and antalgic, rising bone density isoreactivity, efficiently solve osteoporosis and the morbidity root of sciatica, it is to osteoporosis and the therapeutic effect of sciatica serves the effect for the treatment of both the principal and secondary aspects of a disease.
(3) the present invention is that inventor is on the basis of secret prescription handed down in the family from generation to generation, in conjunction with the summary of clinical experience for many years, obtain through repeatedly testing, therefore this medicine osteoporosis that a variety of causes is caused sciatica has unique curative effect, this medicine compatibility science, curative effect is rapid, the advantage that instant effect, short treating period, cure rate are high, expense is little.
Summary of the invention
Detailed description of the invention
The present invention is further described below by way of specific embodiment, but described embodiment not limiting the present invention in any way.
one) example of formulations part
embodiment 1 Chinese medicine composition of the present invention and preparation technology
Prescription is composed as follows: Rhizoma et radix veratri (Radix Rhizoma Veratri) 8 parts, Rhizoma Chuanxiong 5 parts, the Radix Paeoniae Alba 5 parts, Herba Eupatorii Lindleyani 3 parts, the Radix Angelicae Dahuricae 10 parts, Herba Sarcandrae 5 parts, Radix Achyranthis Bidentatae 10 parts, Herba Phyllanthi Urinariae 3 parts, Radix Bupleuri 10 parts, Radix Salviae Miltiorrhizae 5 parts, 8 parts, Poria, 5 parts, Radix Rehmanniae Preparata, Radix Puerariae 10 parts, Herba Asari 3 parts, Herba Menthae 5 parts, Herba Xanthii 3 parts, Fructus Ligustri Lucidi 3 parts, Herba Epimedii 5 parts, Fructus Lycii 10 parts, Fructus Corni 10 parts, Radix Saposhnikoviae 3 parts, Semen Cuscutae 5 parts, Os Bovis seu Bubali powder 5 parts, the Radix Astragali 5 parts, 10 parts, Radix Glycyrrhizae.
Preparation method: get above-mentioned Chinese crude drug by weight and be broken into coarse powder, adds according to 4 times of coarse powder gross weight the alcoholic solution that volumetric concentration is 40%, reflux, extract, three times, return time is 5h, filters, filtrate recycling ethanol, cold filtration, washes with water, namely obtains Chinese medical concrete after drying; Chinese medical concrete is pulverized and adds preparation and commonly use adjuvant and be prepared into tablet or capsule.
embodiment 2 Chinese medicine composition of the present invention and preparation technology
Prescription is composed as follows: Rhizoma et radix veratri (Radix Rhizoma Veratri) 20 parts, Rhizoma Chuanxiong 15 parts, the Radix Paeoniae Alba 15 parts, Herba Eupatorii Lindleyani 10 parts, the Radix Angelicae Dahuricae 25 parts, Herba Sarcandrae 15 parts, Radix Achyranthis Bidentatae 20 parts, Herba Phyllanthi Urinariae 10 parts, Radix Bupleuri 20 parts, Radix Salviae Miltiorrhizae 15 parts, 20 parts, Poria, 12 parts, Radix Rehmanniae Preparata, Radix Puerariae 20 parts, Herba Asari 10 parts, Herba Menthae 15 parts, Herba Xanthii 10 parts, Fructus Ligustri Lucidi 10 parts, Herba Epimedii 12 parts, Fructus Lycii 15 parts, Fructus Corni 20 parts, Radix Saposhnikoviae 10 parts, Semen Cuscutae 15 parts, Os Bovis seu Bubali powder 15 parts, the Radix Astragali 25 parts, 20 parts, Radix Glycyrrhizae.
Preparation method: get the above-mentioned Chinese crude drug of recipe quantity and be broken into coarse powder, add according to 5 times of coarse powder gross weight the alcoholic solution that volumetric concentration is 90%, reflux, extract, three times, return time is 3h, filters, filtrate recycling ethanol, cold filtration, washes with water, namely obtains Chinese medical concrete after drying; Chinese medical concrete is pulverized and adds preparation and commonly use adjuvant and be prepared into tablet or capsule.
embodiment 3 Chinese medicine composition of the present invention and preparation technology
Prescription is composed as follows: Rhizoma et radix veratri (Radix Rhizoma Veratri) 15 parts, Rhizoma Chuanxiong 10 parts, the Radix Paeoniae Alba 10 parts, Herba Eupatorii Lindleyani 7 parts, the Radix Angelicae Dahuricae 18 parts, Herba Sarcandrae 10 parts, Radix Achyranthis Bidentatae 15 parts, Herba Phyllanthi Urinariae 7 parts, Radix Bupleuri 15 parts, Radix Salviae Miltiorrhizae 10 parts, 14 parts, Poria, 9 parts, Radix Rehmanniae Preparata, Radix Puerariae 15 parts, Herba Asari 7 parts, Herba Menthae 10 parts, Herba Xanthii 7 parts, Fructus Ligustri Lucidi 6 parts, Herba Epimedii 8 parts, Fructus Lycii 13 parts, Fructus Corni 15 parts, Radix Saposhnikoviae 7 parts, Semen Cuscutae 10 parts, Os Bovis seu Bubali powder 10 parts, the Radix Astragali 20 parts, 15 parts, Radix Glycyrrhizae.
Preparation method: get the above-mentioned Chinese crude drug of recipe quantity and be broken into coarse powder, add according to 5 times of coarse powder gross weight the alcoholic solution that volumetric concentration is 70%, reflux, extract, three times, return time is 4h, filters, filtrate recycling ethanol, cold filtration, washes with water, namely obtains Chinese medical concrete after drying; Chinese medical concrete is pulverized and adds preparation and commonly use adjuvant and be prepared into tablet or capsule.
embodiment 4 Chinese medicine composition of the present invention and preparation technology
Prescription is composed as follows: Rhizoma et radix veratri (Radix Rhizoma Veratri) 12 parts, Rhizoma Chuanxiong 12 parts, the Radix Paeoniae Alba 10 parts, Herba Eupatorii Lindleyani 5 parts, the Radix Angelicae Dahuricae 16 parts, Herba Sarcandrae 11 parts, Radix Achyranthis Bidentatae 13 parts, Herba Phyllanthi Urinariae 6 parts, Radix Bupleuri 20 parts, Radix Salviae Miltiorrhizae 10 parts, 10 parts, Poria, 8 parts, Radix Rehmanniae Preparata, Radix Puerariae 16 parts, Herba Asari 6 parts, Herba Menthae 10 parts, Herba Xanthii 5 parts, Fructus Ligustri Lucidi 8 parts, Herba Epimedii 7 parts, Fructus Lycii 10 parts, Fructus Corni 14 parts, Radix Saposhnikoviae 10 parts, Semen Cuscutae 5 parts, Os Bovis seu Bubali powder 15 parts, the Radix Astragali 15 parts, 17 parts, Radix Glycyrrhizae.
Preparation method: get the above-mentioned Chinese crude drug of recipe quantity and be broken into coarse powder, add according to 5 times of coarse powder gross weight the alcoholic solution that volumetric concentration is 70%, reflux, extract, three times, return time is 4h, filters, filtrate recycling ethanol, cold filtration, washes with water, namely obtains Chinese medical concrete after drying; Adding ethanol to alcohol content is 75%(v/v), leave standstill 24 hours, get supernatant, reclaim ethanol and concentrate, add water to 1000ml, stir evenly, subpackage, flowing steam sterilization 35min, obtains mixture.
embodiment 5 Chinese medicine composition of the present invention and preparation technology
Prescription is composed as follows: Rhizoma et radix veratri (Radix Rhizoma Veratri) 13 parts, Rhizoma Chuanxiong 13 parts, the Radix Paeoniae Alba 11 parts, Herba Eupatorii Lindleyani 6 parts, the Radix Angelicae Dahuricae 17 parts, Herba Sarcandrae 13 parts, Radix Achyranthis Bidentatae 14 parts, Herba Phyllanthi Urinariae 6 parts, Radix Bupleuri 19 parts, Radix Salviae Miltiorrhizae 11 parts, 11 parts, Poria, 9 parts, Radix Rehmanniae Preparata, Radix Puerariae 18 parts, Herba Asari 8 parts, Herba Menthae 11 parts, Herba Xanthii 5 parts, Fructus Ligustri Lucidi 8 parts, Herba Epimedii 7 parts, Fructus Lycii 11 parts, Fructus Corni 15 parts, Radix Saposhnikoviae 9 parts, Semen Cuscutae 6 parts, Os Bovis seu Bubali powder 14 parts, the Radix Astragali 15 parts, 16 parts, Radix Glycyrrhizae.
Preparation method is with embodiment 4.
embodiment 6 Chinese medicine composition of the present invention and preparation technology
Prescription is composed as follows: Rhizoma et radix veratri (Radix Rhizoma Veratri) 14 parts, Rhizoma Chuanxiong 10 parts, the Radix Paeoniae Alba 13 parts, Herba Eupatorii Lindleyani 6 parts, the Radix Angelicae Dahuricae 20 parts, Herba Sarcandrae 15 parts, Radix Achyranthis Bidentatae 20 parts, Herba Phyllanthi Urinariae 3 parts, Radix Bupleuri 16 parts, Radix Salviae Miltiorrhizae 9 parts, 11 parts, Poria, 7 parts, Radix Rehmanniae Preparata, Radix Puerariae 16 parts, Herba Asari 7 parts, Herba Menthae 11 parts, Herba Xanthii 5 parts, Fructus Ligustri Lucidi 10 parts, Herba Epimedii 12 parts, Fructus Lycii 15 parts, Fructus Corni 16 parts, Radix Saposhnikoviae 10 parts, Semen Cuscutae 15 parts, Os Bovis seu Bubali powder 12 parts, the Radix Astragali 18 parts, 17 parts, Radix Glycyrrhizae.
Preparation method is with embodiment 4.
(2) test examples part
the antiinflammatory action of embodiment 7 Chinese medicine composition xylol of the present invention induced mice inflammatory model
Hydrocortisone has stronger anti-inflammatory activity, be synthetic be also naturally occurring glucocorticoid, after hydrocortisone enters cell, activate cytoplasmic receptor, nucleus is entered after allosteric, be combined with DNA response element, cause suppression or the induction of genetic transcription, the expression of inflammation related proteins is changed.
, experimental technique:
40 KM mices, male and female half and half, body weight 25-30 gram, four groups are divided at random, i.e. dosage group in model control group, combination group high dose group, compositions, compositions low dose group, positive controls by body weight, often organize 10, each administration group mice gives following medicine respectively:
Model control group: gavage gives the normal saline of same volume;
Positive controls: gavage gives the hydrocortisone drug solution of 5mg/kg;
Compositions high dose group: gavage gives 50mg/kg embodiment 1 Chinese medicine composition Chinese medicine composition by crude drug gauge;
Dosage group in compositions: gavage gives 20 mg/kg embodiment 1 Chinese medicine compositions, and Chinese medicine composition presses crude drug gauge;
Compositions low dose group: gavage gives 5 mg/kg embodiment 1 Chinese medicine compositions, and Chinese medicine composition presses crude drug gauge;
Each administration group is administered once every day, successive administration 7d.Get dimethylbenzene 20 μ l after last administration, be applied to each mouse right ear.Get after 30 minutes and be respectively evenly applied to mouse right ear respectively by reagent 0.03 ml, auris dextra is put to death after 3.5 hours to dimethylbenzene, measures each group of mice left and right ear method of double differences.Ear method of double differences assay method: place cuts two ears along auricle baseline, lays auricle with 8mm card punch at the same position of left and right ear, weighs, the ear method of double differences=auris dextra sheet weight-left auricle weight.The ear method of double differences can be used as evaluates antiinflammatory index.
, experimental result:
Measure the antiphlogistic effects that each experimental mice ear method of double differences evaluates each medication group medicine.Measurement result is in table 1.
Table 1 each experimental mice ear method of double differences compares
Compare with model control group,
* p< 0.05; Compare with model control group,
* p< 0.01; Compare with positive controls,
# p< 0.05; Compare with positive controls,
## p< 0.01.
Result display gives positive drug and Chinese medicine composition of the present invention all can obtain significant antiphlogistic effects, wherein the antiphlogistic effects of Chinese medicine composition high dose group of the present invention and positive controls have pole significant difference, Chinese medicine composition low dose group and positive controls have significant difference, and this shows that the high dose group of Chinese medicine composition of the present invention and the antiphlogistic effects of low dose group significantly will be better than positive controls.
embodiment 8 Chinese medicine composition of the present invention affects mouse hot-plate analgesic
1, mouse hot-plate pain model makes
About body weight 20g female mice is placed on hot plate dolorimeter, screen qualified ♀ mice 90 (to lick metapedes time < 5 s or > 30 s to throw aside, scald for preventing foot, also deadline should be established, be generally 60s), the incubation period of metapedes reaction is added for threshold of pain index with mice, get 72 jennies, be divided into 6 groups, 12/group, i.e. model group, cydiodine, Huanglianshangqing Tablet group, Chinese medicine composition of the present invention (obtaining by Chinese medicine composition prescription described in embodiment 1 and preparation technology) low dose group, middle dosage group and high dose group.Each group is gastric infusion, and 1 times/day, dosage is as shown in table 10, and after successive administration 14d, after measuring last medicine, 60 min, 120 min add the time of foot reaction.
, Chinese medicine composition of the present invention on lick in mouse hot-plate analgesic experiment foot the response latency impact
Mice licks foot response latency time showing, compare with model group, after administration after 1h and 2h, the incubation period that the mice of each administration group of Chinese medicine composition of the present invention adds foot reaction is all greater than model group, there is dose-dependence, and be significantly greater than the incubation period of high dose group model group (
p< 0.05).What illustrate that this Chinese medicine composition of the present invention can extend that mice stimulates hot plate adds the sufficient response latency, has certain analgesic activity.Under same experiment condition, positive control drug cydiodine group (
p< 0.05) and Huanglianshangqing Tablet group (1h,
p< 0.05; 2h,
p< 0.01) also extend the incubation period that mice adds foot reaction, there is certain analgesic activity, but its analgesic effect and model group there was no significant difference.The results are shown in Table 3.
Table 2 mice lick foot response latency timetable (
)
Note: compare with model group, *
p< 0.05, * *
p< 0.01.
embodiment 9 Chinese medicine composition of the present invention is to the therapeutical effect of retinoic acid rats with osteoporosis
1, model rat with osteoporosis makes and administration
60 SD female rats, each batch of rat is divided into 6 groups all at random, often organizes 10, and each component cage is fed.1st group is blank group, gavages a certain amount of distilled water every day; 2nd group is model group, gavages a certain amount of retinoic acid 1% Carboxymethyl cellulose sodium suspension (80mg/kg) every day; 3rd group is QIANGGU JIAONANG group, gavages a certain amount of retinoic acid 1% Carboxymethyl cellulose sodium suspension (80mg/kg) and a certain amount of QIANGGU JIAONANG 1% carboxyl methyl cellulose sodium suspension (12 mg/kg) every day; 4th, 5,6 groups are respectively the basic, normal, high dosage group of Chinese medicine composition, gavage the Carboxymethyl cellulose sodium suspension (being equivalent to raw medicinal herbs 5 mg/kg, 20 mg/kg, 50 mg/kg respectively) of a certain amount of retinoic acid 1% Carboxymethyl cellulose sodium suspension (80 mg/kg) and Chinese medicine composition every day, after gavaging 14 d continuously, continue after changing retinoic acid suspension into distilled water to gavage to 30 d only.
Observation item and method: after last administration 24 h, take body weight, anaesthetize with pentobarbital sodium (30 mg/kg), the whole body of each group of rat is scanned with xR-36 type dynamic filtration dual intensity x line bone density diagnostic apparatus, measure left and right tibia respectively, the bone density (bone mineral density BMD) of lower neck bone and lumbar vertebra
2, result of the test
Each group of data all represent with (x scholar s), carry out t check significance analysis with SPSS software kit 10.0.Chinese medicine composition is on as shown in table 3 on the impact of BMD.
Table 3 Chinese medicine composition is on the impact of the bone density of osteoporosis model
Compare with blank group, * * P < 0.01; Contrast with model group, #P < 0.05, ##P < 0.01.
Model group compares with blank group, and the BMD of left tibia, right tibia, lower neck bone and lumbar vertebra all has significant difference, shows that the bone mineral content that retinoic acid causes osteoporosis rat obviously declines.Compare with model group, QIANGGU JIAONANG group and Chinese medicine composition of the present invention are respectively organized and all can be raised rat bone mineral content.Wherein low, high, the middle dosage group of Chinese medicine composition of the present invention compares with model group, significantly improve the BMD of model mouse left tibia, right tibia, lower neck bone and lumbar vertebra, show that the Chinese medicine composition of doses obviously can increase the bone mineral content content that retinoic acid causes osteoporosis model, and high, middle dosage group has significance compared with QIANGGU JIAONANG group to the bone mineral content content of osteoporosis model difference.
the clinical therapeutic efficacy of embodiment 10 Chinese medicine composition of the present invention
For showing that Chinese medicine of the present invention is to osteoporosis and the therapeutic effect of sciatica, the present inventor is to 200 routine case clinical observations, primary osteoporosis and Secondary Sciatic Pain patient 72 example, all measure through U.S. Luner company DPS-L type dual intensity X line borne densitometers, bone density (BMD) is lower than corresponding normal age section peak bone mass two standard deviations, age is 52 years old ~ 88 years old, average out to (64.3 ± 12.1) year.The diagnostic criteria (1) of sciatica has along conductivity radiated pain in sciatic nerve distributed areas; (2) nerve trunk tenderness is had; (3) sciatic nerve tractive levies the positive; (4) motion in various degree within the scope of sciatic nerve domination, sensation reflex and autonomic nerve dysfunction, common Achilles tendon reflex lowers or disappears; Inclusive criteria: meet diagnostic criteria, tcm diagnosis is wind cold wetness type or double liver renal deficiency type arthromyodynia patient.Discharge standard: the sciatica that the reasons such as proliferative spondylitis, tuberculous spondylitis, tumor cause.
All experimenters are through physical examination, and hepatic and renal function is normal, without endocrinopathy and Ca,P metabolism disorder, do not have metabolic osteopathy medical history in the past, do not take hormone medicine.All cases all have lumbago in various degree and osteoarthrosis pain, and the course of disease is all within 1 year.According to patient age, sex, bone density, pain degree pairing is divided into 2 groups at random.Treatment group 36 example, man 18 example, female 18 example, 64 years old mean age; Matched group 36 example, man 18 example, female 18 example, 67 years old mean age.Between group, there is comparability P>0.05
Experimental group uses embodiment 3 gained Chinese medicine capsules, one day twice, and each 20mg/kg takes sooner or later after meal every day half an hour.Matched group intramuscular injection calcitonin (Novartis Norvatis produces, and 50 IU/ prop up), first week 50 IU1 time, intramuscular injection 50 IU 2 times weekly later.Two groups was all 1 course for the treatment of with 30 days, evaluated curative effect after 3 courses for the treatment of.
Curative effect situation criterion: 1, fully recover: clinical symptom disappearance; 2, effective: symptom takes an evident turn for the better; 3, effective: symptom takes a turn for the better to some extent; 4, invalid: symptom, sign are without improvement.
After taking medicine of the present invention, 26 people cure, and cure rate reaches 72.2%, and 8 people are effective, and total effective rate reaches 94.5%.Matched group cures 25 examples, and effective 5 examples, cure rate is 69.4, and total effective rate is 83.4%.
Claims (4)
1. treat osteoporosis and a Chinese medicine composition for sciatica, it is characterized in that being obtained by the raw material of following weight portion: Rhizoma et radix veratri (Radix Rhizoma Veratri) 8 parts, Rhizoma Chuanxiong 5 parts, the Radix Paeoniae Alba 5 parts, Herba Eupatorii Lindleyani 3 parts, the Radix Angelicae Dahuricae 10 parts, Herba Sarcandrae 5 parts, Radix Achyranthis Bidentatae 10 parts, Herba Phyllanthi Urinariae 3 parts, Radix Bupleuri 10 parts, Radix Salviae Miltiorrhizae 5 parts, 8 parts, Poria, 5 parts, Radix Rehmanniae Preparata, Radix Puerariae 10 parts, Herba Asari 3 parts, Herba Menthae 5 parts, Herba Xanthii 3 parts, Fructus Ligustri Lucidi 3 parts, Herba Epimedii 5 parts, Fructus Lycii 10 parts, Fructus Corni 10 parts, Radix Saposhnikoviae 3 parts, Semen Cuscutae 5 parts, Os Bovis seu Bubali powder 5 parts, the Radix Astragali 5 parts, 10 parts, Radix Glycyrrhizae.
2. treat osteoporosis as claimed in claim 1 and the Chinese medicine composition of sciatica, it is characterized in that: described Chinese medicine composition is powder, water preparation, tablet or capsule.
3. treat osteoporosis as claimed in claim 1 and the preparation method of the Chinese medicine composition of sciatica, it is characterized in that comprising following processing step: take Chinese crude drug by weight and be broken into coarse powder, the alcoholic solution that volumetric concentration is 40% ~ 95% is added according to 4 ~ 9 times of coarse powder gross weight, reflux, extract, three times, return time is 2 ~ 5h, filters, filtrate recycling ethanol, cold filtration, washes with water, namely obtains Chinese medical concrete after drying; Those skilled in the art can prepare conventional Chinese medicine pharmaceutical dosage form clinically on the basis of described Chinese medical concrete.
4. treatment osteoporosis according to claim 1 the Chinese medicine composition of the sciatica purposes in preparation osteoporosis and in sciatica medicine.
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Owner name: QIDONG TIANFEN ELECTRIC TOOL TECHNOLOGY INNOVATION Free format text: FORMER OWNER: LI WEILI Effective date: 20150630 |
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Effective date of registration: 20150630 Address after: Qidong City, Jiangsu province 226200 Nantong lvsigang Tianfen electric tools trade city comprehensive building Patentee after: Qidong Tianfen Electric Tool Technology Innovation Center Address before: Jimo City, Shandong province 266200 Jhengtong street Qingdao City No. 20 Patentee before: Li Weili |