CN103585414A - Pharmaceutical composition for treating sciatica and osteoporosis - Google Patents
Pharmaceutical composition for treating sciatica and osteoporosis Download PDFInfo
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Abstract
The invention discloses pharmaceutical composition for treating sciatica and osteoporosis, and belongs to the technical field of traditional Chinese medicine. The pharmaceutical composition comprises raw materials in parts by weight as follows: 8-20 parts of black false hellebore, 5-15 parts of ligusticum wallichii, 5-15 parts of radix paeoniae alba, 3-10 parts of lindley eupatorium, 10-25 parts of radix angelicae, 5-15 parts of herba sarcandrae, 10-20 parts of roots of bidentate achyranthes, 3-10 parts of underleaf pearl, 10-20 parts of Chinese thorowax root, 5-15 parts of roots of red-rooted salvia, 8-20 parts of poria cocos, 5-12 parts of radix rehmanniae praeparata, 10-20 parts of radix puerariae, 3-10 parts of asarum, 5-15 parts of mint, 3-10 parts of Siberian cocklebur, 3-10 parts of glossy privet fruit, 5-12 parts of herba epimedii, 10-15 parts of fruit of Chinese wolfberry, 10-20 parts of dogwood, 3-10 parts of radix sileris, 5-15 parts of seeds of Chinese dodder, 5-15 parts of bovine-derived powder, 5-25 parts of astragalus and 10-20 parts of liquorice. Pharmacology experiments and clinical experiments prove that the pharmaceutical composition has an obvious effect in treating the sciatica and the osteoporosis and wide medical popularization values.
Description
Technical field
The invention belongs to technical field of Chinese medicines, be specifically related to a kind of pharmaceutical composition for the treatment of sciatica osteoporosis.
Background technology
Osteoporosis is common ailment of middle-aged and old, frequently-occurring disease, have a strong impact on such crowd's Health and Living quality, osteoporosis and the fracture causing thereof occupy the 7th in current common disease, during serious threat, old people's health, make it to become global public health problem.At present, aged tendency of population is day by day serious, improves the control consciousness of osteoporosis is had very important significance.Osteoporosis is to reduce (comprising the minimizing of bone mineral and substrate equal proportion) with bone amount, osseous tissue microstructure deteriorates to feature, showing as trabecular bone structure destroys, attenuates and rupture, and then cause the fragility of bone to increase, biomechanics of bone intensity decreases, load holding capacity reduces, and is easy to occur a kind of general skeletal diseases of capillary fracture or complete fracture.Patients with osteoporosis cardinal symptom is lumbar and back pain, hunchback, easily fractures clinically, and how with the performance of suffering from a deficiency of the kidney, as lumbar and back pain, hyposexuality etc., has had a strong impact on life and quality of life.According to the United Nations's statistics aging, oneself became irreversible worldwide trend of 21st century, and China has entered aging society in 1999.Chinese society's aging speed is faster than country's total population growth rate, according to incompletely statistics, 60 years old above senile osteoporosis disease sickness rate of China is about 59.89%, therefore increases bone density, effectively treats the important topic that osteoporosis has become people's extensive concern.
In international osteoporosis foundation (IOF) world's osteoporosis conference in 2004, Univ Sheffield UK's WHO metabolic osteopathy research center Johnell etc. analyzes 12 clinical researches, and 30,000 9 thousand people in 12 cohort studies are included in this research in.Find that bone density value is lower, the probability of happening of osteoporotic fracture and all kinds fracture is higher, and this situation rule in 65 years old age group is the most obvious.Bone density (BMD) full name is skeleton mineral density, is an important indicator of bone strength, and it is 75%～85% relevant with bone density that the intensity of osseous tissue has.The bone density of bone density phalanges unit are, refers to and the tightness degree of osseous tissue combination is often referred to bone mineral content.Bone density is to weigh at present an osteoporotic index objectively quantizing, and is also that an index ，Qi unit of reflection bone amount is g/c ㎡, and bone density is higher, and sclerotin intensity is better.The factor analysis such as it and skeletal structure, bone amount, bone mineral content.
Aging along with the age, the bone density of each skeleton of the whole body is all downward trend gradually, and bone density drops to a certain degree, is easy to fracture.The mechanism that bone density declines is that bone metabolism is unbalance, and people's bone metabolism before 35 years old is vigorous, and the calcium of absorption absorbs to enter in skeleton very soon and precipitates, and rapidly, now bone is the strongst in bone growth regeneration.Due to osteoblastic effect in skeleton, bone formation is greater than bone loss during this period.Women 35 years old, male be after 40 years old, and because gastrointestinal function weakens, osteotrophy absorbs and reduces and increases of running off, bone formation and osteoclasia disequilibrium, and in performance bone structure, bone trabecula destroys, and attenuates, fracture, gap become greatly, hollow.If treating not in time or can not get effective treatment, osteoporosis usually can cause Secondary Sciatic Pain.
Sciatica refers to the pain of sciatic nerve path and distribution thereof, i.e. the pain in outside and foot outside after buttocks thigh rear side, shank.If pain is shown effect repeatedly, with the passing of time there will be the atrophy of Ipsilateral lower limb muscles, or occur walking lamely.Sciatica is not disease independently, but the syndrome being caused by various diseases.In China, primary sciatica is very rare, only accounts for 1%, and having in addition more than 98% sciatica is to be caused by spinal lesion.The disease that causes clinically Secondary Sciatic Pain is more, common following disease or the symptom of mainly containing: (1) causes that the most common disease of sciatica of nerve roots is prolapse of lumbar intervertebral disc, also has lumbar spinal stenosis and intervertebral foramina stenosis and waist hyperosteogeny rachitis in addition; (2) congenital malformation, is also comparatively common reason, as abnormal in spina bifida occulta, lumbar sacralization, little joint disorders and processus transversus vertebrarum etc.; (3) outside, injure soft tissue diseases, as lumbosacral region fracture, hypertrophy of ligamentum flavum, muscle fiber are knitted inflammation; (4) osteoarticular inflammation and infection, as ankylosing spondylitis, spondylocace, suppurative spondylitis; (5) some other disease, as osteoporosis, subarachnoid hemorrhage, angiopathy etc.
According to bone density, lack the difference that produces reason and the mechanism of action, can select diverse ways to increase bone density, clinical treatment adopts calcium preparation, activated vitamin D, gonadal hormone, calcitonin, diphosphonate and fluoride etc. more at present, though there is certain curative effect, but side effect is large, somewhat expensive, and cure the symptoms, not the disease.Aspect treatment, western medicine still lacks effective measures, and medicinal application is also very limited.Simple replenishing the calcium only can delay but can not stop the loss of bone amount, therefore research and develop a kind of efficient supplementing and run off calcareous and can consolidate and prevent that bone amount runs off and safe without toxic side effect, thereby fundamentally solve osteoporotic medicine, become and urgently need the problem that solves.
Chinese medicine is of long standing and well established, its treatment osteoporosis with and the Secondary Sciatic Pain that causes aspect accumulated abundant clinical practice and theory of Chinese medical science, as take theory of Chinese medical science as guidance, have kidney invigorating and YANG supporting, replenishing QI to invigorate the spleen, the methods such as adjusting liver of invigorating blood circulation.The traditional Chinese medical science thinks that bone density decline cause has two, one to be deficiency of kidney-essence, has saying of " kidney governing bones, raw marrow fills brain, its Hua Fa ", therefore muscles and bones is unable for deficiency of kidney-essence in tcm theory; Two is spleen deficiency of kidney-QI, and the merit of insufficiency of the spleen mistake transporting is deficiency of kidney-essence, and skeleton loses supports, so fragile unable.
Summary of the invention
In prior art, chemicals is cured the symptoms, not the disease, and easily produces hormonal medicaments toleration, and poisonous side effect of medicine is large, and Chinese medicine exists uncertain therapeutic efficacy fixed, lacks relative medicine preparation.In order to overcome above-mentioned the deficiencies in the prior art, the object of this invention is to provide and a kind ofly can effectively treat osteoporosis sciatica and instant effect, short treating period, Chinese medicine that cure rate is high.
For realizing object of the present invention, now according to following technical scheme, Chinese medicine composition of the present invention is to be made by the raw material of following weight portion: Rhizoma et radix veratri (Radix Rhizoma Veratri) 8-20 part, Rhizoma Chuanxiong 5-15 part, Radix Paeoniae Alba 5-15 part, Herba Eupatorii Lindleyani 3-10 part, Radix Angelicae Dahuricae 10-25 part, Herba Sarcandrae 5-15 part, Radix Achyranthis Bidentatae 10-20 part, Herba Phyllanthi Urinariae 3-10 part, Radix Bupleuri 10-20 part, Radix Salviae Miltiorrhizae 5-15 part, Poria 8-20 part, Radix Rehmanniae Preparata 5-12 part, Radix Puerariae 10-20 part, Herba Asari 3-10 part, Herba Menthae 5-15 part, Herba Xanthii 3-10 part, Fructus Ligustri Lucidi 3-10 part, Herba Epimedii 5-12 part, Fructus Lycii 10-15 part, Fructus Corni 10-20 part, Radix Saposhnikoviae 3-10 part, Semen Cuscutae 5-15 part, Os Bovis seu Bubali powder 5-15 part, Radix Astragali 5-25 part, Radix Glycyrrhizae 10-20 part.
Difference according to Chinese medicine composition to osteoporosis sciatica therapeutic effect is preferably as follows on above-mentioned Chinese medicine composition basis:
(1) 15 parts of Rhizoma et radix veratri (Radix Rhizoma Veratri)s, 10 parts of Rhizoma Chuanxiongs, 10 parts of the Radix Paeoniae Albas, 7 parts of Herba Eupatorii Lindleyanis, 18 parts of the Radixs Angelicae Dahuricae, 10 parts of Herba Sarcandraes, 15 parts of Radix Achyranthis Bidentataes, 7 parts of Herba Phyllanthi Urinariaes, 15 parts of Radix Bupleuri, 10 parts of Radix Salviae Miltiorrhizaes, 14 parts, Poria, 9 parts, Radix Rehmanniae Preparata, 15 parts of Radix Puerariaes, 7 parts of Herba Asaris, 10 parts of Herba Menthaes, 7 parts of Herba Xanthiis, 6 parts of Fructus Ligustri Lucidi, 8 parts of Herba Epimedii, 13 parts of Fructus Lycii, 15 parts of Fructus Corni, 7 parts of Radix Saposhnikoviaes, 10 parts of Semen Cuscutae, 10 parts of Os Bovis seu Bubali powder, 20 parts of the Radixs Astragali, 15 parts, Radix Glycyrrhizae.
(2) 8 parts of Rhizoma et radix veratri (Radix Rhizoma Veratri)s, 5 parts of Rhizoma Chuanxiongs, 5 parts of the Radix Paeoniae Albas, 3 parts of Herba Eupatorii Lindleyanis, 10 parts of the Radixs Angelicae Dahuricae, 5 parts of Herba Sarcandraes, 10 parts of Radix Achyranthis Bidentataes, 3 parts of Herba Phyllanthi Urinariaes, 10 parts of Radix Bupleuri, 5 parts of Radix Salviae Miltiorrhizaes, 8 parts, Poria, 5 parts, Radix Rehmanniae Preparata, 10 parts of Radix Puerariaes, 3 parts of Herba Asaris, 5 parts of Herba Menthaes, 3 parts of Herba Xanthiis, 3 parts of Fructus Ligustri Lucidi, 5 parts of Herba Epimedii, 10 parts of Fructus Lycii, 10 parts of Fructus Corni, 3 parts of Radix Saposhnikoviaes, 5 parts of Semen Cuscutae, 5 parts of Os Bovis seu Bubali powder, 5 parts of the Radixs Astragali, 10 parts, Radix Glycyrrhizae.
(3) 20 parts of Rhizoma et radix veratri (Radix Rhizoma Veratri)s, 15 parts of Rhizoma Chuanxiongs, 15 parts of the Radix Paeoniae Albas, 10 parts of Herba Eupatorii Lindleyanis, 25 parts of the Radixs Angelicae Dahuricae, 15 parts of Herba Sarcandraes, 20 parts of Radix Achyranthis Bidentataes, 10 parts of Herba Phyllanthi Urinariaes, 20 parts of Radix Bupleuri, 15 parts of Radix Salviae Miltiorrhizaes, 20 parts, Poria, 12 parts, Radix Rehmanniae Preparata, 20 parts of Radix Puerariaes, 10 parts of Herba Asaris, 15 parts of Herba Menthaes, 10 parts of Herba Xanthiis, 10 parts of Fructus Ligustri Lucidi, 12 parts of Herba Epimedii, 15 parts of Fructus Lycii, 20 parts of Fructus Corni, 10 parts of Radix Saposhnikoviaes, 15 parts of Semen Cuscutae, 15 parts of Os Bovis seu Bubali powder, 25 parts of the Radixs Astragali, 20 parts, Radix Glycyrrhizae.
(4) 12 parts of Rhizoma et radix veratri (Radix Rhizoma Veratri)s, 12 parts of Rhizoma Chuanxiongs, 10 parts of the Radix Paeoniae Albas, 5 parts of Herba Eupatorii Lindleyanis, 16 parts of the Radixs Angelicae Dahuricae, 11 parts of Herba Sarcandraes, 13 parts of Radix Achyranthis Bidentataes, 6 parts of Herba Phyllanthi Urinariaes, 20 parts of Radix Bupleuri, 10 parts of Radix Salviae Miltiorrhizaes, 10 parts, Poria, 8 parts, Radix Rehmanniae Preparata, 16 parts of Radix Puerariaes, 6 parts of Herba Asaris, 10 parts of Herba Menthaes, 5 parts of Herba Xanthiis, 8 parts of Fructus Ligustri Lucidi, 7 parts of Herba Epimedii, 10 parts of Fructus Lycii, 14 parts of Fructus Corni, 10 parts of Radix Saposhnikoviaes, 5 parts of Semen Cuscutae, 15 parts of Os Bovis seu Bubali powder, 15 parts of the Radixs Astragali, 17 parts, Radix Glycyrrhizae.
In order to express better Chinese medicine composition of the present invention, Chinese medicine composition of the present invention can be prepared into conventional clinically dosage form.Such as, the preparations such as powderous preparations, powder, pill, sublimed preparation, unguentum, granule, oral liquid, syrup, tablet, capsule, described pharmaceutical preparation all can prepare according to Chinese medicine preparation preparation method well-known to those skilled in the art.Preferably, Chinese medicine composition of the present invention is prepared into powder, water preparation, tablet or capsule according to conventional preparation technology.
The present invention also provides a kind of preparation method of above-mentioned Chinese medicine composition, it mainly comprises following step: get by weight above-mentioned Chinese crude drug and be broken into coarse powder, according to 4～9 times of coarse powder gross weight, adding volumetric concentration is 40%～95% alcoholic solution, reflux, extract, three times, return time is 2～5h, filters, filtrate recycling ethanol, cold filtration, washes with water, after being dried, obtains Chinese medical concrete; Those skilled in the art can be at the technical conventional Chinese medicine pharmaceutical dosage form clinically for preparing of this preparation method, as tablet, capsule etc.
According to Chinese medicine Historical Data Data About, the pharmacologically active of above-mentioned Chinese crude drug is as follows:
Rhizoma et radix veratri (Radix Rhizoma Veratri) is used for the treatment of the diseases such as middle wind-phlegm heap soil or fertilizer over and around the roots, epilepsy, lymphangitis, malaria, mastitis, fracture, traumatic injury, tinea capitis, scabies, and maggot, fly etc. also can be used for going out; It can promote union of fracture, thereby shortens healing time, especially outstanding with fracture of shaft of femur, and the average clinical healing date is 37 days, but healing time length and classification of fracture and manual reduction technology have obvious relation;
Rhizoma Chuanxiong, original name rhizome of chuanxiong Qiong; , being usually used in blood-activating and qi-promoting, wind-expelling pain-stopping, cures mainly menoxenia, dysmenorrhea, amenorrhea, difficult labour, retention of placenta, lochia stomachache, lump, heart pain in chest and hypochondrium, traumatic injury swells and ache, headache vertigo and head dark, anemofrigid-damp arthralgia, numb limbs and tense tendons, ulcer sores; Blood circulation promoting and blood stasis dispelling effect is extensive, the various diseases of suitable stagnation of blood stasis; Wind-expelling pain-stopping, effectiveness is excellent, can control the diseases such as wind syndrome of head headache, rheumatic arthralgia; It is the gas medicine in blood that former times people calls Rhizoma Chuanxiong, nearly says the functions such as pungent loose, the resolving depression of its residence, sensible, pain relieving;
The Radix Paeoniae Alba is cool in nature, and bitter in the mouth acid, is slightly cold, and has the easing the affected liver of enriching blood, suppressing the hyperactive liver pain relieving.Yin fluid astringing is received the effects such as antiperspirant, is applicable to fever due to yin deficiency, menoxenia, the breast abdomen pain over the hypochondriac region, extremity contraction anxious, dysentery stomachache, spontaneous sweating, metrorrhagia, is with inferior disease; That its paeoniflorin containing has is antibiotic, antipyretic, antiinflammatory, increase coronary flow, improve the effect of myocardial nutritional flow, blood vessel dilating, antagonism acute myocardial ischemia, anticoagulant, calmness, analgesia, spasmolytic, antiulcer, adjusting blood glucose;
The white drum nail of Herba Eupatorii Lindleyani another name, relieving dyspepsia grass, hair Herba Lycopi, bitter in the mouth, property is flat; Cure mainly: don't lung cough-relieving, resolving phlegm and relieving asthma, blood pressure lowering;
Radix Angelicae Dahuricae expelling wind and cold, understand things pain-stopping, the evacuation of pus of invigorating blood circulation, granulation promoting pain relieving, dampness leukorrhagia stopping; For mastalgia, swell and ache, have a headache, toothache, nasal sinusitis, hemorrhoidal hamorrhage anal fistula, leucorrhea with red and white discharge, ulcer sores, skin pruritus; The modern pharmacological research proof Radix Angelicae Dahuricae also has antiinflammatory, antipyretic-antalgic, active eliminating stagnation, can be used for controlling the effects such as mammary gland caking with other Chinese Medicine and Clavicular;
Herba Sarcandrae, function cures mainly: anti-inflammation, dispelling wind and removing obstruction in the collateral, blood circulation promoting and dispersing pathogen accumulation; For pneumonia, appendicitis, cellulitis, rheumatic arthralgia, injury from falling down, tumor; Treat in addition rheumatoid arthritis, 4 examples on probation, each intramuscular injection 4ml (every ml is containing 2 grams of crude drugs), every day 3 times, continuously 1-2 week; Preliminary observation, has certain short term effect;
Radix Achyranthis Bidentatae, invigorating the liver and kidney, bone and muscle strengthening, eliminating blood stasis and inducing menstruation, conducting blood to flow downwards; For soreness of waist and knee joint, muscles and bones is unable, amenorrhea lump in the abdomen, dizziness due to hyperactivity of liver-YANG; The traditional Chinese medical science thinks, its property bitter but sweet flavor acid is flat, has promoting blood circulation to restore menstrual flow, invigorating the liver and kidney, bone and muscle strengthening, inducing diuresis for treating stranguria syndrome, draws the descending effect of blood (fire), be usually used in treating the gynaecopathia such as amenorrhea, dysmenorrhea, menoxenia, puerperal abdonimal pain of stagnation of blood stasis, traumatic injury, the soreness of waist and knee joint of suffering from a deficiency of the kidney, weakness of the lower extremities, hematuria; dysuria, Urethra astringent pain and intimately go up the diseases such as headache that inflammation causes, dizzy, haematemesis, epistaxis;
Herba Phyllanthi Urinariae, micro-hardship, sweet, cool; Function cures mainly: clearing away heat and promoting diuresis, improving eyesight, removing food stagnancy; For oedema due to nephritis, urinary system infection, calculus, enteritis, dysentery, infantile malnutrition, eye keratitis, icterohepatitis, external is controlled Trimeresurus stejnegeri and is bitten;
Radix Bupleuri, cold nature, bitter in the mouth, pungent, return Liver Channel, gallbladder meridian, tool depressed liver-energy dispersing and function of gallbladder promoting, dredge gas resolving depression, loose effect of fire; Radix Bupleuri (processed with vinegar), bitter in the mouth, cold nature, returns liver, gallbladder meridian; Processed with vinegar can relax and rise loose property, strengthens dispersing the depressed liver-QI for alleviating pain effect, is applicable to hypochondriac pain, stomachache and the menoxenia of stagnation of QI due to depression of the liver, and normal and Fructus Aurantii, Rhizoma Cyperi, Rhizoma Chuanxiong are equal to use; Sanguis Trionycis Radix Bupleuri is bitter, is slightly cold, and returns liver, gallbladder meridian.Sanguis Trionycis is processed and can be suppressed to rise floating property, and enhancing liver heat removing is brought down a fever, preventing the attack (or recurrence) of malaria effect; Normal and Herba Artemisiae Annuae, Cortex Lycii, the Radix Paeoniae Alba, Gypsum Fibrosum, the Rhizoma Anemarrhenae are equal to use, strengthen the effect of the exterior and the interior reducing the asthenic fever;
Radix Salviae Miltiorrhizae, there is promoting blood circulation to remove blood stasis, detumescence hemostasis, anti-inflammatory analgetic, menstruction regulating and pain relieving, coronary artery dilator, improve myocardial ischemia situation, with all worries set aside, blood sugar lowering and the effect such as antibiotic reduce blood pressure, calm the nerves, to menoxenia, amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia; Hepatosplenomegaly, the diseases such as angina pectoris have certain curative effect; In addition, modern medicine experiment showed, that Radix Salviae Miltiorrhizae also has the function of anti-platelet aggregation, reduction blood viscosity and the inside and outside blood coagulation system of adjusting, is that a kind of safety is treated again the natural Chinese medicine of cardiovascular disease reliably; Radix Salviae Miltiorrhizae Tabellae is the Chinese patent medicine of blood circulation promoting and blood stasis dispelling, regulating QI to relieve pain; The disease such as be mainly used in angina pectoris, hypertension, cervical spondylosis and feel oppressed in the heart; And the side effect reliable, Radix Salviae Miltiorrhizae Tabellae of its drug effect is little;
Poria sweet in the mouth, light, property are flat, be used as medicine there is promoting diuresis to eliminate damp pathogen, the function of strengthening the spleen stomach function regulating, mind tranquilizing and the heart calming; Modern medicine study: Poria energy enhancing human body immunity function, pachyman has obvious antitumor and protects the liver dirty effect; Can control dysuria, edema distension, phlegm retention cough with dyspnea, vomiting, malignant histocytosis, have loose bowels, seminal emission, stranguria with turbid discharge, palpitation with fear, the disease such as forgetful; Contained pachymic acid has the effect of enhancing immunity, antitumor and calmness, blood sugar lowering etc.; The gastrointestinal smooth muscle that can relax, the effect such as gastric acid secretion inhibiting, prevents hepatic necrosis, antibiotic;
Radix Rehmanniae Preparata, vital essence replenishing and marrow benifiting, bone and muscle strengthening, < < detailed outline > >: " fill out bone marrow; longue meat; promoting generation of vital essence and blood, tonifying five ZANG-organs internal injury is not enough, promoting blood circulation; sharp knowledge; black beard and hair, and man's five kinds of strain and seven kinds of impairment, woman's damaging the spleen and stomach threatened abortion; irregular menorrhea, tire produces all kinds of diseases and ailments; " its impact on medulla hematopoietic system: Radix Rehmanniae Preparata water decoction gavages every 0.5g to posthemorrhagic anemia mice; every day 1 time; continuous 10 days; can promote the recovery of anemia animal erythrocyte, hemoglobin, accelerates propagation, the differentiation of pluripotential hemopoietic stem cell (CFU-S), bone marrow hemopoietic progenitor cell of red blood cell line (CFU-E);
Radix Puerariae, sweet in the mouth is micro-pungent, and gas delicate fragrance is cool in nature; Function cures mainly: yang invigorating expelling pathogenic factors from muscles, and rash antidiarrheal, relieving restlessness is temperature only; Cold, the warm headache stiffness of the nape that cures the wound, dysphoria with smothery sensation is quenched one's thirst, has loose bowels, dysentery, skin eruption is not saturating, hypertension, angina pectoris, deaf, diarrhea due to hypofunction of the spleen, the disease such as cure mainly that fever caused by exogenous pathogens, head and neck pain are strong, measles is sent out smooth, epidemic febrile disease is thirsty, quench one's thirst, alcoholism, obstruction of qi in the chest and cardialgia thoroughly;
Herba Asari, dispels the wind, cold expelling, and row water, has one's ideas straightened out; Control air-cooled headache, nasal sinusitis, toothache, phlegm retention cough with dyspnea, rheumatic arthralgia; Herba Asari volatile oil has obvious central inhibitory action, can calm, analgesia and antipyretic; Higenamine separated from Herba Asari has the extensive physiological action of adrenergic beta-agonist sample, thereby has the effects such as heart tonifying, blood vessel dilating, relaxing smooth muscle, enhancing lipid metabolism and rising blood glucose;
Herba Menthae is cool in nature, and sweet in the mouth is pungent, is a kind of conventional Chinese medicine, is widely used; Cure mainly dispelling wind, dispel the heat, ward off dirty, removing toxic substances, affection due to external wind and heat, headache, laryngopharynx swelling and pain, dyspepsia flatulence, aphtha, toothache, skin ulcer scabies, urticaria, epidemic febrile disease be from the beginning of, rubella pruritus, stagnation of QI due to depression of the liver, hypochondriac pain uncomfortable in chest;
Herba Xanthii, toil, cold, poisonous; Cure mainly flu, wind syndrome of head, dizziness, nasal sinusitis, conjunctival congestion, corneal nebula, pathogenic wind-warm arthralgia pain, contracture numbness, wind leprosy, furuncle, scabies, skin pruritus, hemorrhoid, dysentery, wind and heat eliminating, removing toxic substances parasite killing, arthralgia chiefly caused by damp pathogen contracture, loose wind dehumidifying, understand things pain-stopping;
Fructus Ligustri Lucidi, has another name called Fructus Ligustri Lucidi, Fructus Ligustri Lucidi in fact, and property is flat, bitter in the mouth, sweet, and the effect of tool replenishing kidney-YIN, nourishing the liver to improve visual acuity belongs to nourishing YIN class medicine in Chinese medicine; Cure mainly Light-headedness, soreness of the waist and knees, tinnitus, early whitening of beard and hair, osteopyrexia and fever, poor vision;
Herba Epimedii, acrid, sweet, warm; Cure mainly kidney-replenishing, bone and muscle strengthening, wind-damp dispelling, dyspnea and cough due to deficiency of the kidney, soreness of the waist and knees, rheumatic arthralgia, hemiplegia, extremity are meciless;
Fructus Lycii, sweet in the mouth, the flat effect with the liver and the kidney tonifying of property, say in < < Compendium of Materia Medica > > and " take for a long time hard muscles and bones, make light of one's life by commiting suicide not old, cold-resistant summer-heat; " traditional Chinese medical science conventional it treat hepatic and renal YIN deficiency, soreness of the waist and knees, dizziness, forgetful, dizzy, the many tear of blurred vision, quench one's thirst, the disease such as seminal emission; Modern pharmacology studies confirm that Fructus Lycii scalable body's immunity, can effectively suppress tumor growth and cell mutation, has slow down aging, the effect of anti-fatty liver, adjusting blood fat and the aspect such as blood glucose, promotion hemopoietic function, and is applied to clinical;
Fructus Corni, < < Compendium of Materia Medica > > carries: " Fructus Corni, cures mainly pathogen cold and heat under the heart, and warming middle-JIAO, by cold warm numbness, goes three worms, and clothes are made light of one's life by commiting suicide for a long time; The merit of have reinforcing YIN-essence benefit essence, settling five organs, logical nine orifices, stopping dribbling urination; Take for a long time improving eyesight, brute force all the year round "; Its sour in the mouth, adstringency, tepor; Return liver, kidney channel.Liver and kidney tonifying, essence astringing and desertion stemming; For vertigo and tinnitus, soreness of waist and knee joint;
Radix Saposhnikoviae, acrid in the mouth, sweet, slightly warm in nature.Effect: expelling pathogenic wind from the body surface, removing dampness to relieve pain, spasmolytic, antipruritic; Cure mainly that affection of exogenous wind-cold, headache general pain, rheumatic arthralgia, joint are ached, stomachache is had loose bowels, discharging fresh blood stool, tetanus, rubella pruritus, skin infection from the beginning of; < < Bencao Jingshu > > records: " it is general that Radix Saposhnikoviae is controlled wind, rises to send out and can fall apart, therefore main large dizziness due to wind pain; aversion to wind ailment said due to cold or exposure; whole body arthralgia numbness, it is next that hypochondriac pain, side of body public attention face go, and extremity contraction suddenly ";
Semen Cuscutae, acrid in the mouth, sweet, flat, nontoxic; Cure mainly the kidney invigorating and essence nourishing, nourishing the liver to improve visual acuity; The waist knee joint muscles and bones that is applicable to deficiency of the liver and kindey is ached, the diseases such as legs and feet weakness, dizziness and blurred vision, blurring of vision, Hiccough and deaf;
The Radix Astragali, sweet in the mouth, slightly warm in nature, returns liver, spleen, lung, kidney channel; There is the effect that benefiting QI for strengthening the superficies, arresting sweating are admittedly de-, hold in the palm skin ulcer granulation promoting, inducing diuresis to remove edema; In traditional Chinese medical science five elements theory, what spring was corresponding is liver, therefore, takes good care of irritability most important for the health preserving in spring; Osteoporosis, lumbar spondylosis, cervical spondylosis, anemia etc., the disease persons such as visible arthralgia, numb spontaneous perspiration, available Huangqi Guizhi Wuwu Tang;
Radix Glycyrrhizae, sweet in the mouth, property is flat, nontoxic; Treating disorders in five ZANG-organs six internal organs cold and heat pathogen, hard muscles and bones, longue meat, times strength, removing toxic substances, clothes are made light of one's life by commiting suicide and are prolonged life for a long time; Raw by pathogenic fire purging heat, the ripe use exterior cold of fall apart, goes pharyngalgia, except pathogenic heat, delays healthy energy, yin nourishing blood, tonifying the spleen and stomach, lung moistening; Eliminate the phlegm, pain relieving, spasmolytic be so that the pharmacological action such as anticancer; In the traditional Chinese medical science, Radix Glycyrrhizae invigorating the spleen and replenishing QI, relieving cough and moistening lung, emergency removing toxic substances, is in harmonious proportion hundred medicines.Clinical practice divides " raw using " and " processed with honey " not; Raw with curing mainly laryngopharynx swelling and pain, cellulitis skin infection, gastrointestinal ulceration and solution poison of drug, alimentary toxicosis etc.; Processed with honey cures mainly spleen and stomach function and goes down, and large loose stool is thin, weak heating and cough, cardiopalmus.
The present invention also asks for protection the purposes of above-mentioned Chinese medicine composition in preparation treatment osteoporosis sciatica medicine.Pharmaceutical composition of the present invention is when treatment osteoporosis sciatica, and demonstrating remarkable anti-inflammatory and antalgic also can significantly increase the activity of bone density.Drug effect embodiment 7 of the present invention shows, give positive drug and Chinese medicine composition of the present invention all can be obtained significant antiphlogistic effects, wherein the antiphlogistic effects of Chinese medicine composition high dose group of the present invention and positive controls have utmost point significant difference, Chinese medicine composition low dose group and positive controls have significant difference, and this shows that the high dose group of Chinese medicine composition of the present invention and the antiphlogistic effects of low dose group will significantly be better than positive controls.Drug effect embodiment 8 mices of the present invention lick foot response latency time showing, with model group comparison, after administration after 1h and 2h, all be greater than model group the incubation period that the mice of each administration group of Chinese medicine composition of the present invention is added foot reaction, there is dose-dependence, and be significantly greater than the incubation period of high dose group model group (
p< 0.05).Illustrate that this Chinese medicine composition of the present invention can extend adding the sufficient response latency that mice stimulates hot plate, has certain analgesic activity.Under same experiment condition, positive control drug cydiodine group (
p< 0.05) and Huanglianshangqing Tablet group (1h,
p< 0.05; 2h,
p< 0.01) also extended the incubation period that mice is added foot reaction, there is certain analgesic activity, but its analgesic effect and model group there was no significant difference.The embodiment of the present invention 9 shows, relatively, the BMD of left tibia, right tibia, lower neck bone and lumbar vertebra all has significant difference for model group and blank group, shows that the bone mineral content that retinoic acid causes osteoporosis rat obviously declines.With model group comparison, each organizes the rat bone mineral content that all can raise bone strengthening Capsules group and Chinese medicine composition of the present invention.Wherein low, high, the middle dosage group of Chinese medicine composition of the present invention and model group comparison, significantly improved the BMD of model mouse left tibia, right tibia, lower neck bone and lumbar vertebra, the Chinese medicine composition that shows doses can obviously increase the bone mineral content content that retinoic acid causes osteoporosis model, and high, middle dosage group is compared the difference with significance to the bone mineral content content of osteoporosis model with bone strengthening Capsules group.
In a word, Chinese medicine composition of the present invention, aspect treatment osteoporosis sciatica, compared with prior art has following advantage:
(1) compare with current chemotherapeutic agent, Chinese medicine composition of the present invention is natural pure Chinese medicinal preparation, untoward reaction and side effect significantly reduce, and Chinese medicine composition effect of the present invention is comprehensive, medication effect is better, significantly improved osteoporosis sciatica patient's compliance, and improved patient's quality of life.
(2) in Chinese medicine composition of the present invention, contain multi-medicament component, action target spot is numerous, pharmacological evaluation shows that it has significant blood circulation promoting and blood stasis dispelling, anti-inflammatory and antalgic, rising bone density isoreactivity, the morbidity root that has effectively solved osteoporosis sciatica, its therapeutic effect to osteoporosis sciatica has played the effect for the treatment of both the principal and secondary aspects of a disease.
(3) the present invention is that inventor is on the basis of secret prescription handed down in the family from generation to generation, in conjunction with the summary of clinical experience for many years, through repeatedly testing, obtain, therefore this medicine causes a variety of causes osteoporosis sciatica have unique curative effect, this medicine compatibility science, curative effect is rapid, instant effect, short treating period, the advantage that cure rate is high, expense is little.
The specific embodiment
By specific embodiment, further describe the present invention below, but described embodiment not limiting the present invention in any way.
(
one) FORMULATION EXAMPLE part
embodiment 1 Chinese medicine composition of the present invention and preparation technology
Write out a prescription composed as follows: 8 parts of Rhizoma et radix veratri (Radix Rhizoma Veratri)s, 5 parts of Rhizoma Chuanxiongs, 5 parts of the Radix Paeoniae Albas, 3 parts of Herba Eupatorii Lindleyanis, 10 parts of the Radixs Angelicae Dahuricae, 5 parts of Herba Sarcandraes, 10 parts of Radix Achyranthis Bidentataes, 3 parts of Herba Phyllanthi Urinariaes, 10 parts of Radix Bupleuri, 5 parts of Radix Salviae Miltiorrhizaes, 8 parts, Poria, 5 parts, Radix Rehmanniae Preparata, 10 parts of Radix Puerariaes, 3 parts of Herba Asaris, 5 parts of Herba Menthaes, 3 parts of Herba Xanthiis, 3 parts of Fructus Ligustri Lucidi, 5 parts of Herba Epimedii, 10 parts of Fructus Lycii, 10 parts of Fructus Corni, 3 parts of Radix Saposhnikoviaes, 5 parts of Semen Cuscutae, 5 parts of Os Bovis seu Bubali powder, 5 parts of the Radixs Astragali, 10 parts, Radix Glycyrrhizae.
Preparation method: get by weight above-mentioned Chinese crude drug and be broken into coarse powder, adding volumetric concentration according to 4 times of coarse powder gross weight is 40% alcoholic solution, reflux, extract, three times, return time is 5h, filters filtrate recycling ethanol, cold filtration, washes with water, after being dried, obtains Chinese medical concrete; Chinese medical concrete is pulverized and added the conventional adjuvant of preparation to be prepared into tablet or capsule.
embodiment 2 Chinese medicine composition of the present invention and preparation technology
Write out a prescription composed as follows: 20 parts of Rhizoma et radix veratri (Radix Rhizoma Veratri)s, 15 parts of Rhizoma Chuanxiongs, 15 parts of the Radix Paeoniae Albas, 10 parts of Herba Eupatorii Lindleyanis, 25 parts of the Radixs Angelicae Dahuricae, 15 parts of Herba Sarcandraes, 20 parts of Radix Achyranthis Bidentataes, 10 parts of Herba Phyllanthi Urinariaes, 20 parts of Radix Bupleuri, 15 parts of Radix Salviae Miltiorrhizaes, 20 parts, Poria, 12 parts, Radix Rehmanniae Preparata, 20 parts of Radix Puerariaes, 10 parts of Herba Asaris, 15 parts of Herba Menthaes, 10 parts of Herba Xanthiis, 10 parts of Fructus Ligustri Lucidi, 12 parts of Herba Epimedii, 15 parts of Fructus Lycii, 20 parts of Fructus Corni, 10 parts of Radix Saposhnikoviaes, 15 parts of Semen Cuscutae, 15 parts of Os Bovis seu Bubali powder, 25 parts of the Radixs Astragali, 20 parts, Radix Glycyrrhizae.
Preparation method: get the above-mentioned Chinese crude drug of recipe quantity and be broken into coarse powder, adding volumetric concentration according to 5 times of coarse powder gross weight is 90% alcoholic solution, reflux, extract, three times, return time is 3h, filters filtrate recycling ethanol, cold filtration, washes with water, after being dried, obtains Chinese medical concrete; Chinese medical concrete is pulverized and added the conventional adjuvant of preparation to be prepared into tablet or capsule.
embodiment 3 Chinese medicine composition of the present invention and preparation technology
Write out a prescription composed as follows: 15 parts of Rhizoma et radix veratri (Radix Rhizoma Veratri)s, 10 parts of Rhizoma Chuanxiongs, 10 parts of the Radix Paeoniae Albas, 7 parts of Herba Eupatorii Lindleyanis, 18 parts of the Radixs Angelicae Dahuricae, 10 parts of Herba Sarcandraes, 15 parts of Radix Achyranthis Bidentataes, 7 parts of Herba Phyllanthi Urinariaes, 15 parts of Radix Bupleuri, 10 parts of Radix Salviae Miltiorrhizaes, 14 parts, Poria, 9 parts, Radix Rehmanniae Preparata, 15 parts of Radix Puerariaes, 7 parts of Herba Asaris, 10 parts of Herba Menthaes, 7 parts of Herba Xanthiis, 6 parts of Fructus Ligustri Lucidi, 8 parts of Herba Epimedii, 13 parts of Fructus Lycii, 15 parts of Fructus Corni, 7 parts of Radix Saposhnikoviaes, 10 parts of Semen Cuscutae, 10 parts of Os Bovis seu Bubali powder, 20 parts of the Radixs Astragali, 15 parts, Radix Glycyrrhizae.
Preparation method: get the above-mentioned Chinese crude drug of recipe quantity and be broken into coarse powder, adding volumetric concentration according to 5 times of coarse powder gross weight is 70% alcoholic solution, reflux, extract, three times, return time is 4h, filters filtrate recycling ethanol, cold filtration, washes with water, after being dried, obtains Chinese medical concrete; Chinese medical concrete is pulverized and added the conventional adjuvant of preparation to be prepared into tablet or capsule.
embodiment 4 Chinese medicine composition of the present invention and preparation technology
Write out a prescription composed as follows: 12 parts of Rhizoma et radix veratri (Radix Rhizoma Veratri)s, 12 parts of Rhizoma Chuanxiongs, 10 parts of the Radix Paeoniae Albas, 5 parts of Herba Eupatorii Lindleyanis, 16 parts of the Radixs Angelicae Dahuricae, 11 parts of Herba Sarcandraes, 13 parts of Radix Achyranthis Bidentataes, 6 parts of Herba Phyllanthi Urinariaes, 20 parts of Radix Bupleuri, 10 parts of Radix Salviae Miltiorrhizaes, 10 parts, Poria, 8 parts, Radix Rehmanniae Preparata, 16 parts of Radix Puerariaes, 6 parts of Herba Asaris, 10 parts of Herba Menthaes, 5 parts of Herba Xanthiis, 8 parts of Fructus Ligustri Lucidi, 7 parts of Herba Epimedii, 10 parts of Fructus Lycii, 14 parts of Fructus Corni, 10 parts of Radix Saposhnikoviaes, 5 parts of Semen Cuscutae, 15 parts of Os Bovis seu Bubali powder, 15 parts of the Radixs Astragali, 17 parts, Radix Glycyrrhizae.
Preparation method: get the above-mentioned Chinese crude drug of recipe quantity and be broken into coarse powder, adding volumetric concentration according to 5 times of coarse powder gross weight is 70% alcoholic solution, reflux, extract, three times, return time is 4h, filters filtrate recycling ethanol, cold filtration, washes with water, after being dried, obtains Chinese medical concrete; Adding ethanol is 75%(v/v to containing alcohol amount), standing 24 hours, get supernatant, reclaim ethanol concentrated, add water to 1000ml, stir evenly, packing, flowing steam sterilization 35min, obtains mixture.
embodiment 5 Chinese medicine composition of the present invention and preparation technology
Write out a prescription composed as follows: 13 parts of Rhizoma et radix veratri (Radix Rhizoma Veratri)s, 13 parts of Rhizoma Chuanxiongs, 11 parts of the Radix Paeoniae Albas, 6 parts of Herba Eupatorii Lindleyanis, 17 parts of the Radixs Angelicae Dahuricae, 13 parts of Herba Sarcandraes, 14 parts of Radix Achyranthis Bidentataes, 6 parts of Herba Phyllanthi Urinariaes, 19 parts of Radix Bupleuri, 11 parts of Radix Salviae Miltiorrhizaes, 11 parts, Poria, 9 parts, Radix Rehmanniae Preparata, 18 parts of Radix Puerariaes, 8 parts of Herba Asaris, 11 parts of Herba Menthaes, 5 parts of Herba Xanthiis, 8 parts of Fructus Ligustri Lucidi, 7 parts of Herba Epimedii, 11 parts of Fructus Lycii, 15 parts of Fructus Corni, 9 parts of Radix Saposhnikoviaes, 6 parts of Semen Cuscutae, 14 parts of Os Bovis seu Bubali powder, 15 parts of the Radixs Astragali, 16 parts, Radix Glycyrrhizae.
Preparation method is with embodiment 4.
embodiment 6 Chinese medicine composition of the present invention and preparation technology
Write out a prescription composed as follows: 14 parts of Rhizoma et radix veratri (Radix Rhizoma Veratri)s, 10 parts of Rhizoma Chuanxiongs, 13 parts of the Radix Paeoniae Albas, 6 parts of Herba Eupatorii Lindleyanis, 20 parts of the Radixs Angelicae Dahuricae, 15 parts of Herba Sarcandraes, 20 parts of Radix Achyranthis Bidentataes, 3 parts of Herba Phyllanthi Urinariaes, 16 parts of Radix Bupleuri, 9 parts of Radix Salviae Miltiorrhizaes, 11 parts, Poria, 7 parts, Radix Rehmanniae Preparata, 16 parts of Radix Puerariaes, 7 parts of Herba Asaris, 11 parts of Herba Menthaes, 5 parts of Herba Xanthiis, 10 parts of Fructus Ligustri Lucidi, 12 parts of Herba Epimedii, 15 parts of Fructus Lycii, 16 parts of Fructus Corni, 10 parts of Radix Saposhnikoviaes, 15 parts of Semen Cuscutae, 12 parts of Os Bovis seu Bubali powder, 18 parts of the Radixs Astragali, 17 parts, Radix Glycyrrhizae.
Preparation method is with embodiment 4.
(2) drug effect embodiment part
the antiinflammatory action of embodiment 7 Chinese medicine composition xylol of the present invention induced mice inflammatory model
Hydrocortisone has stronger anti-inflammatory activity, that synthetic is also naturally occurring glucocorticoid, hydrocortisone enters after cell, activate cytoplasmic receptor, after allosteric, enter nucleus, be combined with DNA response element, cause inhibition or the induction of genetic transcription, the expression of inflammation associated protein is changed.
experimental technique:
40 KM mices, male and female half and half, body weight 25-30 gram, by body weight, be divided at random four groups, i.e. dosage group in model control group, combination group high dose group, compositions, compositions low dose group, positive controls, every group 10, each administration group mice gives respectively following medicine:
Model control group: gavage gives the normal saline of same volume;
Positive controls: gavage gives the hydrocortisone drug solution of 5mg/kg;
Compositions high dose group: gavage gives 50mg/kg embodiment 1 Chinese medicine composition Chinese medicine composition by crude drug amount;
Dosage group in compositions: gavage gives 20 mg/kg embodiment 1 Chinese medicine compositions, and Chinese medicine composition is by crude drug amount;
Compositions low dose group: gavage gives 5 mg/kg embodiment 1 Chinese medicine compositions, and Chinese medicine composition is by crude drug amount;
Each administration group is administered once every day, successive administration 7d.After last administration, get dimethylbenzene 20 μ l, be applied to each mouse right ear.After 30 minutes, get and be respectively subject to reagent 0.03 ml to be evenly applied to respectively mouse right ear, auris dextra is put to death after 3.5 hours to dimethylbenzene, measures and respectively organizes the mice left and right ear method of double differences.Ear method of double differences assay method: place cuts two ears along auricle baseline, lays auricle with 8mm card punch at the same position of left and right ear, weighs, and the ear method of double differences=auris dextra sheet weight-left auricle weight.The ear method of double differences can be used as evaluates antiinflammatory index.
experimental result:
Measure each experimental mice ear method of double differences and evaluate the antiphlogistic effects of each medication group medicine.Measurement result is in Table 1.
Each experimental mice ear method of double differences comparison of table 1
With model control group comparison,
* p< 0.05; With model control group comparison,
* p< 0.01; With positive controls comparison,
# p< 0.05; With positive controls comparison,
## p< 0.01.
Result demonstration gives positive drug and Chinese medicine composition of the present invention all can be obtained significant antiphlogistic effects, wherein the antiphlogistic effects of Chinese medicine composition high dose group of the present invention and positive controls have utmost point significant difference, Chinese medicine composition low dose group and positive controls have significant difference, and this shows that the high dose group of Chinese medicine composition of the present invention and the antiphlogistic effects of low dose group will significantly be better than positive controls.
the impact of embodiment 8 Chinese medicine composition of the present invention on mice hot-plate analgesia
1, mice hot plate pain model is made
Body weight 20g left and right female mice is placed on hot plate dolorimeter, screen 90 of qualified ♀ mices and (lick metapedes time < 5 s or > 30 s throw aside, for preventing foot, scald, also should establish deadline, be generally 60s), be the threshold of pain index incubation period that the mice of take is added metapedes reaction, get 72 jennies, be divided into 6 groups, 12/group, it is model group, cydiodine, Huanglianshangqing Tablet group, Chinese medicine composition of the present invention (making by Chinese medicine composition prescription and preparation technology described in embodiment 1) low dose group, middle dosage group and high dose group.Each group is gastric infusion, and 1 times/day, dosage is as shown in table 10, after successive administration 14d, and the time that after mensuration last medicine, 60 min, 120 min add foot reaction.
2, Chinese medicine composition of the present invention is on licking the impact of foot response latency in the experiment of mice hot-plate analgesia
Mice licks foot response latency time showing, with model group comparison, after administration after 1h and 2h, be all greater than model group the incubation period that the mice of each administration group of Chinese medicine composition of the present invention is added foot reaction, there is dose-dependence, and be significantly greater than the incubation period of high dose group model group (
p< 0.05).Illustrate that this Chinese medicine composition of the present invention can extend adding the sufficient response latency that mice stimulates hot plate, has certain analgesic activity.Under same experiment condition, positive control drug cydiodine group (
p< 0.05) and Huanglianshangqing Tablet group (1h,
p< 0.05; 2h,
p< 0.01) also extended the incubation period that mice is added foot reaction, there is certain analgesic activity, but its analgesic effect and model group there was no significant difference.The results are shown in Table 3.
Table 2 mice lick foot response latency timetable (
)
Note: with model group comparison, *
p< 0.05, * *
p< 0.01.
the therapeutical effect of embodiment 9 Chinese medicine composition of the present invention to retinoic acid rats with osteoporosis
1, model rat with osteoporosis is made and administration
60 SD female rats, each batch of rat is divided into 6 groups all at random, and 10 every group, each component cage is fed.The 1st group is blank group, gavages a certain amount of distilled water every day; The 2nd group is model group, gavages a certain amount of retinoic acid 1% Carboxymethyl cellulose sodium suspension (80mg/kg) every day; The 3rd group is bone strengthening Capsules group, gavages a certain amount of retinoic acid 1% Carboxymethyl cellulose sodium suspension (80mg/kg) and a certain amount of bone strengthening capsule 1% carboxyl methyl cellulose sodium suspension (12 mg/kg) every day; 4th, 5,6 groups are respectively the basic, normal, high dosage group of Chinese medicine composition, gavage the Carboxymethyl cellulose sodium suspension (being equivalent to respectively raw medicinal herbs 5 mg/kg, 20 mg/kg, 50 mg/kg) of a certain amount of retinoic acid 1% Carboxymethyl cellulose sodium suspension (80 mg/kg) and Chinese medicine composition every day, gavage continuously after 14 d, by retinoic acid suspension change into continue to gavage after distilled water to 30 d only.
Observation item and method: after last administration 24 h, take body weight, with pentobarbital sodium (30 mg/kg), anaesthetize, with the scanning of xR-36 type dynamic filtration dual intensity x line bone density diagnostic apparatus, respectively organize the whole body of rat, measure respectively left and right tibia, the bone density of lower neck bone and lumbar vertebra (bone mineral density BMD)
2, result of the test
Each is organized data and all uses (x scholar s) to represent, with SPSS software kit 10.0, carries out t check significance analysis.Chinese medicine composition is as shown in table 3 on the impact on BMD.
The impact of table 3 Chinese medicine composition on the bone density of osteoporosis model
With the comparison of blank group, * * P < 0.01; With model group contrast, #P < 0.05, ##P < 0.01.
Relatively, the BMD of left tibia, right tibia, lower neck bone and lumbar vertebra all has significant difference for model group and blank group, shows that the bone mineral content that retinoic acid causes osteoporosis rat obviously declines.With model group comparison, each organizes the rat bone mineral content that all can raise bone strengthening Capsules group and Chinese medicine composition of the present invention.Wherein low, high, the middle dosage group of Chinese medicine composition of the present invention and model group comparison, significantly improved the BMD of model mouse left tibia, right tibia, lower neck bone and lumbar vertebra, the Chinese medicine composition that shows doses can obviously increase the bone mineral content content that retinoic acid causes osteoporosis model, and high, middle dosage group is compared the difference with significance to the bone mineral content content of osteoporosis model with bone strengthening Capsules group.
the clinical therapeutic efficacy of embodiment 10 Chinese medicine compositions of the present invention
For showing the therapeutic effect of Chinese medicine of the present invention to osteoporosis sciatica, the inventor is to 200 routine case clinical observations, primary osteoporosis and Secondary Sciatic Pain patient 72 examples, the Jun Jing U.S. DPS-L of Luner company type dual intensity X line borne densitometers is measured, bone density (BMD) is lower than two standard deviations of corresponding normal age section peak bone mass, age is 52 years old～88 years old, average out to (64.3 ± 12.1) year.The diagnostic criteria of sciatica (1) has along conductivity radiated pain in sciatic nerve distributed areas; (2) there is nerve trunk tenderness; (3) sciatic nerve tractive is levied the positive; (4) motion, sensation reflex and vegetative nerve obstacle in various degree within the scope of sciatic nerve domination, common Achilles tendon reflex lowers or disappears; Inclusive criteria: meet diagnostic criteria, tcm diagnosis is wind cold wetness type or double liver renal deficiency type arthromyodynia patient.Discharge standard: the sciatica that the reasons such as proliferative spondylitis, tuberculous spondylitis, tumor cause.
All experimenters are through physical examination, and hepatic and renal function is normal, without endocrinopathy and calcium, disorders of phosphorus metabolism, do not have in the past metabolic osteopathy medical history, do not take hormone medicine.All cases all have lumbago and osteoarthrosis pain in various degree, and the course of disease is all within 1 year.According to patient age, sex, bone density, pain degree pairing is divided into 2 groups at random.Treatment group 36 examples, male 18 examples, female's 18 examples, 64 years old mean age; Matched group 36 examples, male 18 examples, female's 18 examples, 67 years old mean age.Between group, there is comparability P>0.05
Experimental group is used embodiment 3 gained Chinese medicine capsules, and one day twice, each 20mg/kg, took every day sooner or later after meal half an hour.Matched group intramuscular injection calcitonin (Novartis Norvatis produce, 50 IU/ prop up), first week 50 IU1 time, intramuscular injection 50 IU 2 times weekly later.All take 30 days as 1 course for the treatment of, after 3 courses for the treatment of, evaluate curative effect for two groups.
Curative effect situation criterion: 1, recovery from illness: clinical symptom disappearance; 2, effective: symptom takes an evident turn for the better; 3, effective: symptom takes a turn for the better to some extent; 4, invalid: symptom, sign are without improvement.
Take after medicine of the present invention, 26 people cure, and it is effective that cure rate reaches 72.2%, 8 people, and total effective rate reaches 94.5%.Matched group is cured 25 examples, effective 5 examples, and cure rate is 69.4, total effective rate is 83.4%.
Claims (8)
1. a Chinese medicine composition for the treatment of osteoporosis sciatica, it is characterized in that being made by the raw material of following weight portion: Rhizoma et radix veratri (Radix Rhizoma Veratri) 8-20 part, Rhizoma Chuanxiong 5-15 part, Radix Paeoniae Alba 5-15 part, Herba Eupatorii Lindleyani 3-10 part, Radix Angelicae Dahuricae 10-25 part, Herba Sarcandrae 5-15 part, Radix Achyranthis Bidentatae 10-20 part, Herba Phyllanthi Urinariae 3-10 part, Radix Bupleuri 10-20 part, Radix Salviae Miltiorrhizae 5-15 part, Poria 8-20 part, Radix Rehmanniae Preparata 5-12 part, Radix Puerariae 10-20 part, Herba Asari 3-10 part, Herba Menthae 5-15 part, Herba Xanthii 3-10 part, Fructus Ligustri Lucidi 3-10 part, Herba Epimedii 5-12 part, Fructus Lycii 10-15 part, Fructus Corni 10-20 part, Radix Saposhnikoviae 3-10 part, Semen Cuscutae 5-15 part, Os Bovis seu Bubali powder 5-15 part, Radix Astragali 5-25 part, Radix Glycyrrhizae 10-20 part.
2. the Chinese medicine composition for the treatment of osteoporosis as claimed in claim 1 sciatica, it is characterized in that being made by the raw material of following weight portion: 15 parts of Rhizoma et radix veratri (Radix Rhizoma Veratri)s, 10 parts of Rhizoma Chuanxiongs, 10 parts of the Radix Paeoniae Albas, 7 parts of Herba Eupatorii Lindleyanis, 18 parts of the Radixs Angelicae Dahuricae, 10 parts of Herba Sarcandraes, 15 parts of Radix Achyranthis Bidentataes, 7 parts of Herba Phyllanthi Urinariaes, 15 parts of Radix Bupleuri, 10 parts of Radix Salviae Miltiorrhizaes, 14 parts, Poria, 9 parts, Radix Rehmanniae Preparata, 15 parts of Radix Puerariaes, 7 parts of Herba Asaris, 10 parts of Herba Menthaes, 7 parts of Herba Xanthiis, 6 parts of Fructus Ligustri Lucidi, 8 parts of Herba Epimedii, 13 parts of Fructus Lycii, 15 parts of Fructus Corni, 7 parts of Radix Saposhnikoviaes, 10 parts of Semen Cuscutae, 10 parts of Os Bovis seu Bubali powder, 20 parts of the Radixs Astragali, 15 parts, Radix Glycyrrhizae.
3. the Chinese medicine composition for the treatment of osteoporosis as claimed in claim 1 sciatica, it is characterized in that being made by the raw material of following weight portion: 8 parts of Rhizoma et radix veratri (Radix Rhizoma Veratri)s, 5 parts of Rhizoma Chuanxiongs, 5 parts of the Radix Paeoniae Albas, 3 parts of Herba Eupatorii Lindleyanis, 10 parts of the Radixs Angelicae Dahuricae, 5 parts of Herba Sarcandraes, 10 parts of Radix Achyranthis Bidentataes, 3 parts of Herba Phyllanthi Urinariaes, 10 parts of Radix Bupleuri, 5 parts of Radix Salviae Miltiorrhizaes, 8 parts, Poria, 5 parts, Radix Rehmanniae Preparata, 10 parts of Radix Puerariaes, 3 parts of Herba Asaris, 5 parts of Herba Menthaes, 3 parts of Herba Xanthiis, 3 parts of Fructus Ligustri Lucidi, 5 parts of Herba Epimedii, 10 parts of Fructus Lycii, 10 parts of Fructus Corni, 3 parts of Radix Saposhnikoviaes, 5 parts of Semen Cuscutae, 5 parts of Os Bovis seu Bubali powder, 5 parts of the Radixs Astragali, 10 parts, Radix Glycyrrhizae.
4. the Chinese medicine composition for the treatment of osteoporosis as claimed in claim 1 sciatica, it is characterized in that being made by the raw material of following weight portion: 20 parts of Rhizoma et radix veratri (Radix Rhizoma Veratri)s, 15 parts of Rhizoma Chuanxiongs, 15 parts of the Radix Paeoniae Albas, 10 parts of Herba Eupatorii Lindleyanis, 25 parts of the Radixs Angelicae Dahuricae, 15 parts of Herba Sarcandraes, 20 parts of Radix Achyranthis Bidentataes, 10 parts of Herba Phyllanthi Urinariaes, 20 parts of Radix Bupleuri, 15 parts of Radix Salviae Miltiorrhizaes, 20 parts, Poria, 12 parts, Radix Rehmanniae Preparata, 20 parts of Radix Puerariaes, 10 parts of Herba Asaris, 15 parts of Herba Menthaes, 10 parts of Herba Xanthiis, 10 parts of Fructus Ligustri Lucidi, 12 parts of Herba Epimedii, 15 parts of Fructus Lycii, 20 parts of Fructus Corni, 10 parts of Radix Saposhnikoviaes, 15 parts of Semen Cuscutae, 15 parts of Os Bovis seu Bubali powder, 25 parts of the Radixs Astragali, 20 parts, Radix Glycyrrhizae.
5. the Chinese medicine composition for the treatment of osteoporosis as claimed in claim 1 sciatica, it is characterized in that being made by the raw material of following weight portion: 12 parts of Rhizoma et radix veratri (Radix Rhizoma Veratri)s, 12 parts of Rhizoma Chuanxiongs, 10 parts of the Radix Paeoniae Albas, 5 parts of Herba Eupatorii Lindleyanis, 16 parts of the Radixs Angelicae Dahuricae, 11 parts of Herba Sarcandraes, 13 parts of Radix Achyranthis Bidentataes, 6 parts of Herba Phyllanthi Urinariaes, 20 parts of Radix Bupleuri, 10 parts of Radix Salviae Miltiorrhizaes, 10 parts, Poria, 8 parts, Radix Rehmanniae Preparata, 16 parts of Radix Puerariaes, 6 parts of Herba Asaris, 10 parts of Herba Menthaes, 5 parts of Herba Xanthiis, 8 parts of Fructus Ligustri Lucidi, 7 parts of Herba Epimedii, 10 parts of Fructus Lycii, 14 parts of Fructus Corni, 10 parts of Radix Saposhnikoviaes, 5 parts of Semen Cuscutae, 15 parts of Os Bovis seu Bubali powder, 15 parts of the Radixs Astragali, 17 parts, Radix Glycyrrhizae.
6. the treatment osteoporosis as described in as arbitrary in claim 1-5 the Chinese medicine composition of sciatica, is characterized in that: described Chinese medicine composition is powder, water preparation, tablet or capsule.
7. the preparation method of the Chinese medicine composition for the treatment of osteoporosis sciatica as described in as arbitrary in claim 1-5, it is characterized in that comprising the steps: getting by weight above-mentioned Chinese crude drug and be broken into coarse powder, according to 4～9 times of coarse powder gross weight, adding volumetric concentration is 40%～95% alcoholic solution, reflux, extract, three times, return time is 2～5h, filters, filtrate recycling ethanol, cold filtration, washes with water, after being dried, obtains Chinese medical concrete; Those skilled in the art can be at the technical conventional Chinese medicine pharmaceutical dosage form clinically for preparing of this preparation method.
8. the treatment osteoporosis as described in as arbitrary in claim 1-5 the purposes of the Chinese medicine composition of sciatica in preparation osteoporosis sciatica medicine.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310569986.XA CN103585414B (en) | 2013-11-16 | 2013-11-16 | Pharmaceutical composition for treating sciatica and osteoporosis |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104027451A (en) * | 2014-05-26 | 2014-09-10 | 烟台瑞智生物医药科技有限公司 | Traditional Chinese medicament for treating liver-kidney deficiency type sciatica |
| CN104524089A (en) * | 2014-12-19 | 2015-04-22 | 广东聚智诚科技有限公司 | Traditional Chinese medicine composition for treatment of lumbar intervertebral disc herniation and sciatica |
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| CN101991716A (en) * | 2009-08-26 | 2011-03-30 | 王新祥 | New application of pharmaceutical composition of vital energy benefiting and smart decoction and the like in prevention and cure of osteoporosis |
| CN102106923A (en) * | 2009-12-29 | 2011-06-29 | 南京中医药大学 | Chinese medicinal preparation for treating osteoporosis |
| CN103285105A (en) * | 2013-06-17 | 2013-09-11 | 贵州鸿德中药开发有限公司 | Traditional Chinese medicine for treating sciatica and preparation method thereof |
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| CN101991716A (en) * | 2009-08-26 | 2011-03-30 | 王新祥 | New application of pharmaceutical composition of vital energy benefiting and smart decoction and the like in prevention and cure of osteoporosis |
| CN102106923A (en) * | 2009-12-29 | 2011-06-29 | 南京中医药大学 | Chinese medicinal preparation for treating osteoporosis |
| CN103285105A (en) * | 2013-06-17 | 2013-09-11 | 贵州鸿德中药开发有限公司 | Traditional Chinese medicine for treating sciatica and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104027451A (en) * | 2014-05-26 | 2014-09-10 | 烟台瑞智生物医药科技有限公司 | Traditional Chinese medicament for treating liver-kidney deficiency type sciatica |
| CN104027451B (en) * | 2014-05-26 | 2015-10-14 | 烟台瑞智生物医药科技有限公司 | A kind of Chinese medicine for the treatment of deficiency of the liver and kindey pattern of syndrome sciatica |
| CN104524089A (en) * | 2014-12-19 | 2015-04-22 | 广东聚智诚科技有限公司 | Traditional Chinese medicine composition for treatment of lumbar intervertebral disc herniation and sciatica |
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