CN101991716A - New application of pharmaceutical composition of vital energy benefiting and smart decoction and the like in prevention and cure of osteoporosis - Google Patents
New application of pharmaceutical composition of vital energy benefiting and smart decoction and the like in prevention and cure of osteoporosis Download PDFInfo
- Publication number
- CN101991716A CN101991716A CN2009101692992A CN200910169299A CN101991716A CN 101991716 A CN101991716 A CN 101991716A CN 2009101692992 A CN2009101692992 A CN 2009101692992A CN 200910169299 A CN200910169299 A CN 200910169299A CN 101991716 A CN101991716 A CN 101991716A
- Authority
- CN
- China
- Prior art keywords
- radix
- osteoporosis
- pharmaceutical composition
- weight portion
- rhizoma
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a new application of medicines or foods for preventing and curing the osteoporosis, relating to the technical field of medicines, wherein the medicines or foods for preventing and curing the osteoporosis are prepared by taking a vital energy benefiting and smart decoction as a main raw material, and the vital energy benefiting and smart decoction is prepared from ginseng or codonopsis pilosula, astragalus root, bugbane, roots of kudzu vine, fructus viticis, radix paeoniae alba, corktree and liquorice. Furthermore, the invention also relates to a new application of medicines or foods for preventing and curing the osteoporosis, wherein the medicines or foods for preventing and curing the osteoporosis are prepared by taking the adding or subtracting formula of the vital energy benefiting and smart decoction or a pharmaceutical composition prepared under the principle of the vital energy benefiting and smart decoction formula as main raw materials. Each raw material medicine can be singly powdered and then mixed, or mixed and then powdered for being directly processed to prepare oral preparation; and the raw material medicines can be singly extracted and then mixed, or mixed firstly and then extracted, to prepare any common pharmaceutical formulation with pharmaceutically acceptable accessories, such as pills, powders, capsules, tablets, medicinal granules, oral liquid and the like.
Description
Technical field
The present invention relates to medical technical field, relating to the pharmaceutical composition of being made up of Radix Ginseng or Radix Codonopsis, the Radix Astragali, Rhizoma Cimicifugae, Radix Puerariae, Fructus Viticis, the Radix Paeoniae Alba, Cortex Phellodendri, Radix Glycyrrhizae that is called yiqi clever soup is primary raw material, preparation is used for prevention and the medicine of treatment osteoporosis (postmenopausal osteoporosis, senile osteoporosis) or the new purposes of food.Simultaneously, the present invention also relates to the plus-minus side of yiqi clever soup or instructing the new pharmaceutical composition that forms down with the yiqi clever soup principles of formulating prescriptions is primary raw material, and preparation is used to prevent and treat the new purposes of the medicine or the food of osteoporosis.
Background technology
Osteoporosis is common complaint among the elderly and frequently-occurring disease, be with the bone amount reduce, bone structure deteriorates to feature, cause the fragility of bone to increase and a kind of general metabolism skeletal diseases of the danger increase of fracture.The main clinical manifestation of osteoporosis is pain, height cripetura, the easy fracture etc. of sending out.The fragility fractures that osteoporosis causes is mainly in vertebra and hip, usually causes long-term bed, loses independent living ability, has a strong impact on old people's physical and mental health, and complication generation back mortality rate is higher.
Yiqi clever soup be Li Dongyuan be used for " the taste deficiency, cataract tinnitus, or blurred vision is dark for many years, look thing can not " prescription.The yiqi clever ball is that the Radix Ginseng in the compositions is changed to Radix Codonopsis as the Chinese patent medicine of the accurate word of traditional Chinese medicines of one of yiqi clever decoction formulation, is applied to be used for deficiency of QI in middle-JIAO, clear YANG failing to ascend, wind-heat troubling, headache margins of eyelids, or deafness and tinnitus, or the disease of blurring of vision is hidden from view in the order life, the Meniere's syndrome that is equivalent to modern medicine, cervical spondylosis, cerebral arteriosclerosis, secretory otitis media, nervous tinnitus, stiff neck, diseases such as achromatopsia.The objective of the invention is to enlarge yiqi clever soup and the yiqi clever Tonga side of subtracting or instructing the new pharmaceutical composition that forms down with the yiqi clever soup principles of formulating prescriptions is the scope of application of preparation in medical domain of primary raw material, is used for osteoporosis prevention and treatment.
Opportunity of the present invention is that we recognize that Li Dongyuan " Treatise on the spleen and stomach " " osteomyelitis " is sick relevant with the notion of modern osteoporosis.The etiology and pathogenesis of Li Dongyuan " osteomyelitis " is to be this with insufficiency of the spleen, rule of treatment method of treatment is a benefiting qi and raising yang, and what form with present Chinese medicine bound pair osteoporosis is main pathogenesis to suffer from a deficiency of the kidney, serves as the treatment general provisions, adds with the kidney invigorating and smartly exist obviously different for the generally understanding of main medication with the kidney invigorating nourishing kidney.Yiqi clever soup protect against osteoporosis just is being based on to be found on the basis of the sick understanding of Li Dongyuan " osteomyelitis ".
1. osteomyelitis " name of disease and etiology and pathogenesis
The name of disease of relevant " osteomyelitis ", Li Dongyuan points out at " Treatise on the spleen and stomach taste win decline opinion ": " weakness of the spleen and stomach on the whole, yang-energy can not be grown, and is that making of spring and summer is not all right, and QI of five ZANG-organs is not given birth to.The then dirty kidney of taking advantage of of the splenopathy, earth restricting water, then bone is weary unable, is to be osteomyelitis, makes us the bone marrow inanition, foot can not be carried out ground ".The sick position that spells out " osteomyelitis " is at bone, etiology and pathogenesis duty in weakness of the spleen and stomach, the taste yang-energy can not rise to be sent out, and loses the foster deficient five internal organs that causes of moistening of the five internal organs.In addition, lay special stress on spleen soil is to the restraint of kidney water, and insufficiency of the spleen causing suffers from a deficiency of the kidney, and makes kidney not give birth to marrow by main bone, becomes " osteomyelitis " of " bone marrow inanition ".The clinical manifestation of " osteomyelitis " is " bone is weary unable " and " foot can not be carried out ground ".
Li Dongyuan is summed up as the bone marrow inanition to the pathogenesis of " osteomyelitis ", and is in full accord with the pathogenesis of osteoporosis.Aspect clinical manifestation, " osteomyelitis " appearance " bone weary unable " and " foot can not be carried out ground ", with osteoporosis sometimes non-evident sympton, occur weak sometimes or pain or take place to fracture and osteodynia occurs or limitation of movement is relevant.In addition,, demonstrate bone persistence, the gradual pathogenic process that is etched or reduces from the literal meaning of " osteomyelitis ", also very identical with pathogenic process or feature that osteoporosis degeneration, insidiousness bone amount reduce.By the comparison and the analysis of above sick position, pathogenesis, symptom and pathogenic process or genius morbi to " osteomyelitis ", can determine that basically " osteomyelitis " is exactly osteoporosis, or be very similar to the disease of osteoporosis.
2. the rule of treatment method of treatment of " osteomyelitis "
The rule of treatment method of treatment of relevant " osteomyelitis ", Li Dongyuan points out that " osteomyelitis " is that " cloudy gas is overlapping, the card of this overabundant YIN leading to insufficient YANG in " the Treatise on the spleen and stomach taste win the opinion that declines ".The rule of treatment cloud, then the healing of antiperspirant, purgation is then dead.If grow stomach,, make the gas of growth prosperous when rising when floating with hot sweet medicine.Say its antiperspirant person, non-positive diaphoresis also, for also supporing yang ".As seen the syndrome of " osteomyelitis " is " cloudy gas is overlapping, the card of overabundant YIN leading to insufficient YANG ".Principle of treatment is " antiperspirant it ", promptly uses the sweating medicine of hot flavor, and to point out to use the sweating medicine purpose be not diaphoresis, but rises with by cloudy gas by helping the spleen sun; And propose hot flavor sweating medicine and use simultaneously with the sugariness Qi-tonifying drug, replenish and rise the yang-energy of a spleen, make QI of the spleen and stomach vigorous, thereby reach the purpose of healing " osteomyelitis ".
Sweating medicine Lee Dong Yuan also is called " wind medicine ", modern Chinese medicine is classified as diaphoretic medicine with it in learning, the wind medical instrument has hot flavor, generally be used for the diseases caused by exogenous pathogenic factor illness, rise the characteristic of sending out, evacuating because the wind medicine also has simultaneously,, send out with vigorous with the liter that keeps temper so Li Dongyuan wind medicine commonly used is helped the spleen sun, be used for multiple miscellaneous diseases caused by endogenous pathogens, and constitute the important component part of present Chinese medical theory.In addition, " osteomyelitis " proposition hot flavor wind medicine and sugariness resistance and supplementing qi medicine are used simultaneously, the legislation of promptly so-called " growing stomach " with the medicine that suffering is sweet, this is this with insufficiency of the spleen, adopts the academic thought of benefiting qi and raising yang method very consistent for miscellaneous diseases caused by endogenous pathogens with Li Dongyuan.
The pathogenesis of " osteomyelitis " loses for the marrow of suffering from a deficiency of the kidney, and on rule of treatment method of treatment, Dong Yuan is directly the kidney invigorating and controlling from Treatise on the spleen and stomach, has reflected taste consequence and effect in the five internal organs, has embodied the academic thought of eastern wall core.Because spleen in five elements' dependent territory, has the advantages that Earth produces myriads of things, be the foundation of acquired constitution, source of generating QI and blood, the prosperity and decline of the five internal organs vital essence depends on taste the change of essence of water and grain is given birth to, and essence in kidney also needs spleenization precise and tiny in to supplement nutrition.Point out as " element ask ancient times innocent opinion ": " the kidney dominating water metabolism is subjected to the essence of five ZANG-organs and six FU-organs and hides it, so plenty of vital essence in five ZANG-organs circulating normally is to rush down ".Though, reach the healing purpose so osteoporotic main pathogenesis makes the kidney qi abundance for the marrow of suffering from a deficiency of the kidney loses by spleen reinforcing.
3. the composition of yiqi clever soup, function cure mainly and the new purposes of protect against osteoporosis
According to Lee Dong Yuan to the etiology and pathogenesis of " osteomyelitis " and the understanding of rule of treatment method of treatment, we find that yiqi clever soup is the prescription that meets very much " growing stomach with hot sweet medicine " legislation, embodied Li Dongyuan to the etiology and pathogenesis of " osteomyelitis " be this with insufficiency of the spleen, the understanding of rule of treatment method of treatment employing benefiting qi and raising yang.
Yiqi clever soup comes from " Dong Yuan examination efficacious prescriptions eye door ", Rhizoma Cimicifugae (7 money half), Radix Puerariae (3 money) and Fructus Viticis (1 money half) by the suffering flavor, the Radix Astragali of sugariness, Radix Ginseng (each 1 money 2 minutes half) and Radix Glycyrrhizae Preparata (5 minutes), assistant is with the Radix Paeoniae of tart flavour and the Cortex Phellodendri of bitterness (each 1 money), and totally 8 flavor medicines are formed.Function is mainly replenishing QI to invigorate the spleen and yang invigorating, and assistant is with tonifying YIN yin fluid astringing and clearing away heat-fire.Wherein the Radix Astragali of sugariness medicine, Radix Ginseng and Radix Glycyrrhizae Preparata be with replenishing QI to invigorate the spleen, and the Rhizoma Cimicifugae of acrid, Radix Puerariae and Fructus Viticis to be rising the spleen sun, assistant with the Radix Paeoniae Alba of tart flavour with the Cortex Phellodendri of tonifying YIN yin fluid astringing and bitterness with clearing away heat-fire.Cure mainly " eating and drinking without temperance, the forced labour body, the taste deficiency, cataract tinnitus, or blurred vision is dark for many years, look thing can not ", and cloud " spirit of clothes order is for a long time crossed doubly, vigour bootstrap, the light body of body is strong, and is clear-headed and clear-sighted ".
Report is not the same in the different in ancient times documents of weight portion of 8 kinds of crude drug of composition yiqi clever soup.In conjunction with modern clinical application experience and experimental studies results, this pharmaceutical composition can be formed by following weight portion: Radix Ginseng or Radix Codonopsis 1-20 weight portion, Radix Astragali 2-30 weight portion, Rhizoma Cimicifugae 1-20 weight portion, Radix Puerariae 2-30 weight portion, Fructus Viticis 1-20 weight portion, Radix Paeoniae Alba 1-20 weight portion, Cortex Phellodendri 1-20 weight portion, Radix Glycyrrhizae 0.1-10 weight portion.
It is relevant that modern medicine thinks that primary osteoporosis and age growth, physical function fail, and sex hormone level plays an important role in the body.To the prevention and the treatment of these illness, controversies in hormone replacement in the elderly has certain curative effect, but because of side effect is bigger, can not finely satisfy clinical needs at present.Under this situation, the native chemical composition that is called phytoestrogen with weak estrogen action of plant origin receives very big concern.Phytoestrogen can play certain estrogen-like effects when estrogen level is not enough in vivo, and plays antagonism when estrogen level is too high in vivo, shows as two-ways regulation, does not find significant side effects, has good safety.Phytoestrogen can substitute estrogen to a certain extent and be used for prevention and treatment of osteoporosis.
Nearest studies show that Radix Puerariae, Rhizoma Cimicifugae etc. contain the phytoestrogen composition, can be used for protect against osteoporosis.Yiqi clever soup contains outside Radix Puerariae, the Rhizoma Cimicifugae, also contains the cooperation of other six kinds of medicines, has fully taken into account old pathology physiological characteristics, reasonable recipe, belong to traditional Chinese medical science classical prescription, therefore for protect against osteoporosis, can expect has better therapeutic than single medicine or time side.In addition, the present invention also expects the plus-minus side of yiqi clever soup or serves as to instruct the Chinese medicine preparation of the new pharmaceutical composition that forms with the principles of formulating prescriptions of the benefiting qi and raising yang of yiqi clever soup, yin fluid astringing pathogenic fire purging, also can be used for prevention and treatment of osteoporosis.
Summary of the invention
The present invention is with the constituent of yiqi clever soup: Radix Ginseng or Radix Codonopsis, the Radix Astragali, Rhizoma Cimicifugae, Radix Puerariae, Fructus Viticis, the Radix Paeoniae Alba, Cortex Phellodendri, Radix Glycyrrhizae are primary raw material, are used to prepare prevention and the medicine of treatment osteoporosis or the purposes of food.Simultaneously, the present invention relates to the plus-minus side of yiqi clever soup or instructing the new pharmaceutical composition that forms down with the yiqi clever soup principles of formulating prescriptions is the Chinese medicine preparation of primary raw material, is used to prevent and treat the new purposes of the medicine or the food of osteoporosis.
Eight kinds of crude drug of yiqi clever soup can be formed by following weight portion: Radix Ginseng or Radix Codonopsis 1-20 weight portion, Radix Astragali 2-30 weight portion, Rhizoma Cimicifugae 1-20 weight portion, Radix Puerariae 2-30 weight portion, Fructus Viticis 1-20 weight portion, Radix Paeoniae Alba 1-20 weight portion, Cortex Phellodendri 1-20 weight portion, Radix Glycyrrhizae 0.1-10 weight portion.Wherein the Radix Astragali of sugariness medicine, Radix Ginseng and Radix Glycyrrhizae Preparata be with replenishing QI to invigorate the spleen, and the Rhizoma Cimicifugae of acrid, Radix Puerariae and Fructus Viticis to be rising the spleen sun, assistant with the Radix Paeoniae Alba of tart flavour with the Cortex Phellodendri of tonifying YIN yin fluid astringing and bitterness with clearing away heat-fire.
According to the principles of formulating prescriptions of yiqi clever soup are analyzed, can be divided into replenishing QI to invigorate the spleen, yang invigorating, tonifying YIN yin fluid astringing and clearing away heat-fire four classes to its employed medicine, so the plus-minus side of the yiqi clever soup that under these principles of formulating prescriptions instruct, forms or new pharmaceutical composition, also can be used for preparing prevention and the medicine of treatment osteoporosis or the purposes of food, it is characterized in that:
Qi-benefiting and spleen-strengthening drug derives from following a kind and arrives several crude drug: Radix Ginseng, Radix Codonopsis, Radix Panacis Quinquefolii, Radix Pseudostellariae, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Rhizoma Dioscoreae, Seem Lablab Album, Poria, Fructus Jujubae, Radix Glycyrrhizae, each crude drug weight ratio can be the 0.1-30 weight portion.
Shengyang medicine derives from following a kind of crude drug to several: Rhizoma Cimicifugae, Radix Puerariae, Fructus Viticis, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, Radix Saposhnikoviae, Radix Stephaniae Tetrandrae, Rhizoma Ligustici, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Herba Schizonepetae, Semen Sojae Preparatum, Rhizoma Zingiberis Recens, each crude drug weight ratio can be the 1-30 weight portion.
Tonifying YIN yin fluid astringing medicine derives from following a kind of crude drug to several: the Radix Paeoniae Alba, Radix Paeoniae Rubra, Colla Corii Asini, Radix Polygoni Multiflori, Radix Rehmanniae Preparata, Carapax Trionycis, Carapax et Plastrum Testudinis, Fructus Ligustri Lucidi, Herba Ecliptae, Fructus Mori, Fructus Lycii, Bulbus Lilii, Rhizoma Polygonati, Rhizoma Polygonati Odorati, Herba Dendrobii, Radix Asparagi, Radix Ophiopogonis, Radix Adenophorae (Radix Glehniae), each crude drug weight ratio can be the 1-30 weight portion.
Heat clearing and fire purging medicine derives from following a kind of crude drug to several: Cortex Phellodendri, Rhizoma Coptidis, Radix Scutellariae, Radix Trichosanthis, Radix Scrophulariae, the Rhizoma Anemarrhenae, Herba Lophatheri, each crude drug weight ratio can be the 1-30 weight portion.
Each crude drug of forming yiqi clever soup, and the plus-minus side of yiqi clever soup or the principles of formulating prescriptions of pressing yiqi clever soup instruct the new pharmaceutical composition that forms down, mix after can being ground into powder separately, or be ground into powder again after mixing, directly be processed into the preparation that to take; Also can mix through crude drug being extracted the back separately, or each crude drug mixed earlier, extract again, be prepared into any common drug dosage form with acceptable accessories then, as pill, powder, capsule, tablet, electuary, oral liquid etc.
Following embodiment and effect experiment example can make yiqi clever soup of the present invention and plus-minus side thereof or the new purposes of the pharmaceutical composition that forms by its principles of formulating prescriptions is achieved and confirms, and should not regard limitation of the present invention as.
The specific embodiment
Embodiment 1
Preparation method (Chinese medicine ministry standard book page number: Z4-164 standard numbering: with Chinese medicine ministry standard yiqi clever ball WS3-B-0820-91) as reference preparation yiqi clever decoction pulvis.That is: Radix Codonopsis 100g, Radix Astragali 100g, Rhizoma Cimicifugae 60g, Radix Puerariae 60g, Cortex Phellodendri (stir-fry) 20g, Radix Paeoniae Alba 20g, Fructus Viticis 30g, Radix Glycyrrhizae (processing) 10g, more than eight flavors, be ground into fine powder, sieve, mixing promptly gets the yiqi clever decoction pulvis.Oral, a 6-18g 1-3 time on the one, is used for prevention and treatment osteoporosis.
Embodiment 2
Get each crude drug: Radix Ginseng 60g, Radix Astragali 120g, Rhizoma Cimicifugae 60g, Radix Puerariae 120g, Fructus Viticis 30g, Cortex Phellodendri 20g, Radix Paeoniae Alba 60g, Radix Glycyrrhizae 10g, more than eight flavors mix, be soaked in 5-10 and doubly extract solvent, reflux, extract, one obtains extracting solution to repeatedly.Extract solvent and can be the 0-95% ethanol water, preferred 30-95% ethanol, preferred 8 times are extracted solvent during reflux, extract,, reflux each 2 hours 3 times.Decompression and solvent recovery, crushed after being dried becomes fine powder, promptly gets the powder of our concentrate or extract.With the powder of gained concentrate or extract and tablet adjuvant commonly used mix, tabletting, promptly get tablet, also can make different dosage forms such as pill, unguentum, mixture routinely.Oral dose is converted according to the concentrated ratio of crude drug.After making tablet, it is 5 times that crude drug final concentrated ratio, and crude drug calculates by take 6-18g at every turn, and the amount that then once should take the tablet after concentrating is 1.2-3.6g, 1-3 time on the one, is used for prevention and treats osteoporosis.
Embodiment 3
Get each crude drug: Radix Ginseng 60g, Radix Astragali 100g, Rhizoma Cimicifugae 60g, Radix Puerariae 100g, Fructus Viticis 30g, Cortex Phellodendri 20g, Radix Paeoniae Alba 60g, Radix Glycyrrhizae 10g, it is soaked in 5-10 doubly extracts solvent respectively, reflux, extract, one gets extracting solution to repeatedly.Extract solvent and can be the 0-95% ethanol water, preferred 30-95% ethanol, preferred 8 times are extracted solvent during reflux, extract,, reflux each 2 hours 3 times.Decompression and solvent recovery, the concentrate of each medicine or extract crushed after being dried are mixed, and add tablet adjuvant commonly used, and tabletting promptly gets tablet, also can make different dosage forms such as pill, unguentum, mixture routinely.After making tablet, it is 5 times that crude drug final concentrated ratio, and crude drug calculates by take 6-18g at every turn, and the amount that then once should take the tablet after concentrating is 1.2-3.6g, 1-3 time on the one.Be used for prevention and treatment osteoporosis.
Experimental example 1
1. material and method
1.1 medicine
Radix Ginseng 90g, Radix Astragali 150g, Rhizoma Cimicifugae 90g, Radix Puerariae 150g, Fructus Viticis 45g, Radix Paeoniae Alba 45g, Cortex Phellodendri 15g, Radix Glycyrrhizae 15g, more than after eight flavors mix, decoct with water secondary, 1.5 hours for the first time, 1 hour for the second time, collecting decoction.Medicinal residues add 70% ethanol water then, soak 2 hours, ultrasonic 30 minutes, extract 3 times.Behind the decompression recycling ethanol, merge decocting liquid and alcohol extract, 98 ℃ of heating concentrate moisture, make the suspension that contains 1.5g/ml yiqi clever decoction compositions, 4 ℃ of cold preservations, and the time spent shakes all.
1.2 animal model and Drug therapy
24 of the female kunming mices in 8 weeks are divided into 3 groups at random: sham operated rats, model group and yiqi clever soup group, 8 every group.Every mouse cage of independently being raised in 24cmx15cmx15cm.In the 12/12h light and shade cycle, ambient temperature is (22 ± 1) ℃.Under 1% pentobarbital sodium anesthesia and sterile working, except that sham operated rats spay and being implemented the sham-operation not, other each organize and all excise the mice bilateral ovaries, make the osteoporosis model of estrogen deficiency.Postoperative, sham operated rats and model group are given and normal saline, and each 0.5ml irritates stomach, every day secondary.Yiqi clever soup group is given and the each 0.5ml of the yiqi clever soup that contains 1.5g/ml irritates stomach, every day secondary.Mice is allowed to freely ingest and drinks water.After 4 weeks of experiment beginning, mice anaesthetized down heart extracting blood cause death die after, extract the bilateral femur and be used for bone densitometry.
1.3 bone density analysis
Take out femur and pick soft tissues such as paying muscle only, put 70% alcohol-pickledly, dry back is measured bone density with dual intensity x line absorption determinator, represents with the bone mineral content on the unit are.The x line sweep zone of femur is divided into three equal parts equidistantly: near-end, middle-end and far-end, analyze bone density in the suffered influence of zones of different.
1.4 date processing
All data are expressed as mean+/-standard error (means ± SEM).(one-wayanalysis of variance ANOVA) judges that it has there was no significant difference by one factor analysis of variance.The level of significant difference is decided to be p＜0.05.
2 results
Femur near, in and in 3 zones of far-end, oophorectomize causes the decline of the bone density of model group distal femur to be compared with the stage casing with near-end, it is particularly remarkable to descend, this is to contain more spongy bone (table 1) owing to this position.In distal femur, the bone density of model group is compared remarkable decline with sham operated rats; The bone density of yiqi clever soup group is compared with model group and is improved, and there were significant differences on the statistics (P＜0.05).
3. conclusion
Postmenopausal osteoporosis mainly is to be caused by the minimizing of spongy bone (medullary substance bone).Therefore yiqi clever soup can significantly suppress the decline of spongy bone bone density, can be used as prevention and treatment osteoporosis agents or food, particularly as the medicine or the food of women's postmenopausal osteoporosis.
Experimental example 2
1. material and method
1.1 medicine
With experimental example 1
1.2 animal model and Drug therapy
24 of the male mouse of kunming in 8 weeks are divided into 3 groups at random: sham operated rats, model group and yiqi clever soup group, 8 every group.Every mouse cage of independently being raised in 24cmx15cmx15cm.In the 12/12h light and shade cycle, ambient temperature is (22 ± 1) ℃.Under anesthesia of 1% pentobarbital sodium and sterile working, except that sham operated rats is granted sham-operation, all implement the male castration operation, make the hypoandrogenism osteoporosis model for all the other two groups.Postoperative, sham operated rats and model group are given and normal saline, and each 0.5ml irritates stomach, every day secondary.Yiqi clever soup group is given and the each 0.5ml of the yiqi clever soup that contains 1.5g/ml irritates stomach, every day secondary.Mice is allowed to freely ingest and drinks water.After 4 weeks of experiment beginning, mice anaesthetized down heart extracting blood cause death die after, extract the bilateral femur and be used for bone densitometry.
1.3 bone density analysis
Take out femur and pick soft tissues such as paying muscle only, put 70% alcohol-pickled after, dry back is measured bone density with dual intensity x line absorption determinator, represents with the bone mineral content on the unit are.The x line sweep zone of femur is divided into three equal parts equidistantly: near-end, middle-end and far-end, analyze bone density in the suffered influence of zones of different.
1.4 date processing
All data are expressed as mean+/-standard error (means ± SEM).(one-wayanalysis of variance ANOVA) judges that it has there was no significant difference by one factor analysis of variance.The level of significant difference is decided to be p＜0.05.
2 results
Femur near, in and in 3 zones of far-end, male castration causes the decline of the bone density of model group distal femur to be compared with the stage casing with near-end, it is particularly remarkable to descend, this is to contain more spongy bone (table 2) owing to this position.In distal femur, the bone density of model group is compared remarkable decline with sham operated rats; The bone density of yiqi clever soup group is compared with model group and is improved, and there were significant differences on the statistics (P＜0.05).
3. conclusion
Therefore yiqi clever soup can significantly suppress the decline of distal femur bone density, can be used as prevention and treatment osteoporosis agents or food, particularly as the medicine or the food of osteoporosis in aged males.
Table 1. yiqi clever soup is to the effect (mg/cmxcm) of removal ovary mouse femur bone density
Annotate: compare Δ P≤0.05 with sham operated rats; Compare ☆ P≤0.05 with model group
The effect (mg/cmxcm) of table 2. yiqi clever soup to going testis mouse femur bone density
Annotate: compare Δ P≤0.05 with sham operated rats; Compare ☆ P≤0.05 with model group
Claims (9)
1. the pharmaceutical composition of yiqi clever soup is the new purposes that main constitutive material is used to prevent and treat the medicine or the food of osteoporosis, and the crude drug of this pharmaceutical composition consists of: Radix Ginseng or Radix Codonopsis 1-20 weight portion, Radix Astragali 2-30 weight portion, Rhizoma Cimicifugae 1-20 weight portion, Radix Puerariae 2-30 weight portion, Fructus Viticis 1-20 weight portion, Radix Paeoniae Alba 1-20 weight portion, Cortex Phellodendri 1-20 weight portion, Radix Glycyrrhizae 0.1-10 weight portion.
2. pharmaceutical composition as claimed in claim 1, the crude drug of this pharmaceutical composition consists of: Radix Ginseng 6 weight portions, the Radix Astragali 12 weight portions, Rhizoma Cimicifugae 6 weight portions, Radix Puerariae 12 weight portions, Fructus Viticis 6 weight portions, the Radix Paeoniae Alba 6 weight portions, Cortex Phellodendri 2 weight portions, Radix Glycyrrhizae 1 weight portion.
3. be main constitutive material as pharmaceutical composition as described in the claim 1-2, by method of pharmacy and the conventional preparation process of knowing, preparation prevention and the medicine of treatment osteoporosis or the purposes of food.
4. yiqi clever Tonga side of subtracting or the new pharmaceutical composition that forms by yiqi clever soup combination principle, be used to prevent and treat the new purposes of the medicine or the food of osteoporosis, it is characterized in that said composition is main the composition by replenishing QI to invigorate the spleen, yang invigorating, tonifying YIN yin fluid astringing and clearing away heat-fire four class crude drug.
5. pharmaceutical composition as claimed in claim 4, it is characterized in that qi-benefiting and spleen-strengthening drug in the said composition derive from following a kind to several crude drug: Radix Ginseng, Radix Codonopsis, Radix Panacis Quinquefolii, Radix Pseudostellariae, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Rhizoma Atractylodis, Rhizoma Dioscoreae, Seem Lablab Album, Poria, Fructus Jujubae, Radix Glycyrrhizae, each crude drug weight ratio is the 0.1-30 weight portion.
6. pharmaceutical composition as claimed in claim 4, it is characterized in that Shengyang medicine in the said composition derive from following a kind to several crude drug: Rhizoma Cimicifugae, Radix Puerariae, Fructus Viticis, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, Radix Saposhnikoviae, Radix Stephaniae Tetrandrae, Rhizoma Ligustici, Rhizoma Chuanxiong, the Radix Angelicae Dahuricae, Herba Schizonepetae, Semen Sojae Preparatum, Rhizoma Zingiberis Recens, each crude drug weight ratio is the 1-30 weight portion.
7. pharmaceutical composition as claimed in claim 4, it is characterized in that tonifying YIN yin fluid astringing medicine in the said composition derive from following a kind to several crude drug: the Radix Paeoniae Alba, Radix Paeoniae Rubra, Colla Corii Asini, Radix Polygoni Multiflori, Radix Rehmanniae Preparata, Carapax Trionycis, Carapax et Plastrum Testudinis, Fructus Ligustri Lucidi, Herba Ecliptae, Fructus Mori, Fructus Lycii, Bulbus Lilii, Rhizoma Polygonati, Rhizoma Polygonati Odorati, Herba Dendrobii, Radix Asparagi, Radix Ophiopogonis, Radix Adenophorae (Radix Glehniae), each crude drug weight ratio is the 1-30 weight portion.
8. pharmaceutical composition as claimed in claim 4, it is characterized in that heat clearing and fire purging medicine in the said composition derive from following a kind to several crude drug: Cortex Phellodendri, Rhizoma Coptidis, Radix Scutellariae, Radix Trichosanthis, Radix Scrophulariae, the Rhizoma Anemarrhenae, Gypsum Fibrosum, Herba Lophatheri, each crude drug weight ratio is the 1-30 weight portion.
9. be main constitutive material as pharmaceutical composition as described in the claim 4-8, by method of pharmacy and the conventional preparation process of knowing, preparation prevention and the medicine of treatment osteoporosis or the new purposes of food.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009101692992A CN101991716A (en) | 2009-08-26 | 2009-08-26 | New application of pharmaceutical composition of vital energy benefiting and smart decoction and the like in prevention and cure of osteoporosis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009101692992A CN101991716A (en) | 2009-08-26 | 2009-08-26 | New application of pharmaceutical composition of vital energy benefiting and smart decoction and the like in prevention and cure of osteoporosis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101991716A true CN101991716A (en) | 2011-03-30 |
Family
ID=43782792
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2009101692992A Pending CN101991716A (en) | 2009-08-26 | 2009-08-26 | New application of pharmaceutical composition of vital energy benefiting and smart decoction and the like in prevention and cure of osteoporosis |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101991716A (en) |
Cited By (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102274415A (en) * | 2011-07-25 | 2011-12-14 | 荣成市商贸城卫生所 | Chinese medicinal composition for treating consumptive disease |
| CN102335295A (en) * | 2011-10-25 | 2012-02-01 | 张绍敏 | Chinese medicinal composition for treating hypotension |
| CN102488215A (en) * | 2011-12-30 | 2012-06-13 | 苏州爱斯欧蒂生物科技有限公司 | Health-caring capsules |
| CN102697927A (en) * | 2012-06-09 | 2012-10-03 | 李承平 | Cold-pungent tablet for resolving fleshy exterior |
| CN102988680A (en) * | 2012-10-16 | 2013-03-27 | 杨晓兵 | Preparation method of medicinal composition for tonifying kidney and spleen, preventing and treating osteoporosis |
| CN102988682A (en) * | 2012-10-16 | 2013-03-27 | 杨晓兵 | Oral liquid for tonifying kidney and spleen and preventing and treating osteoporosis |
| CN103461805A (en) * | 2013-08-18 | 2013-12-25 | 青岛福加德面粉有限公司 | Flour for osteoporosis patients to eat |
| CN103585414A (en) * | 2013-11-16 | 2014-02-19 | 李伟丽 | Pharmaceutical composition for treating sciatica and osteoporosis |
| CN103656121A (en) * | 2013-12-06 | 2014-03-26 | 山东中大药业有限公司 | Immunity-improving traditional Chinese medicine composition and preparation method thereof |
| CN103860779A (en) * | 2014-03-14 | 2014-06-18 | 薛丹 | Traditional Chinese medicine for treating sciatica and preparation method thereof |
| CN104225198A (en) * | 2014-09-29 | 2014-12-24 | 洛阳御平国生物科技有限公司 | Traditional Chinese medicine formula for treating hypermyotonia |
| CN104398802A (en) * | 2014-12-05 | 2015-03-11 | 李崇铭 | Traditional Chinese medicine preparation for strengthening spines and invigorating bones as well as preparation method thereof |
| CN104560581A (en) * | 2015-02-05 | 2015-04-29 | 彭正中 | Health wine for building bodies and preparation process of health wine |
| CN104771501A (en) * | 2014-01-09 | 2015-07-15 | 叶宗勲 | Traditional Chinese medicine composition used for preventing and treating alzheimer's disease |
| CN105125860A (en) * | 2015-10-23 | 2015-12-09 | 吴伶 | Preparation for effectively treating osteoporosis |
| CN104147409B (en) * | 2014-07-22 | 2016-11-23 | 竺妙飞 | One treats the yin asthenia generating intrinsic heat osteoporotic Chinese medicine of pattern of syndrome menopausal women |
| CN106177437A (en) * | 2016-08-02 | 2016-12-07 | 北京天物四方生物科技有限公司 | A kind of improve the maca composition that women yang deficiency body is cold |
| CN106237083A (en) * | 2016-08-31 | 2016-12-21 | 王捷 | The plant amedica compositions of yin-nourishing and health |
| CN110898089A (en) * | 2019-12-27 | 2020-03-24 | 西北工业大学 | Traditional Chinese medicine extract composition for treating osteoporosis |
-
2009
- 2009-08-26 CN CN2009101692992A patent/CN101991716A/en active Pending
Cited By (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102274415B (en) * | 2011-07-25 | 2013-05-01 | 周新春 | Chinese medicinal composition for treating consumptive disease |
| CN102274415A (en) * | 2011-07-25 | 2011-12-14 | 荣成市商贸城卫生所 | Chinese medicinal composition for treating consumptive disease |
| CN102335295A (en) * | 2011-10-25 | 2012-02-01 | 张绍敏 | Chinese medicinal composition for treating hypotension |
| CN102488215A (en) * | 2011-12-30 | 2012-06-13 | 苏州爱斯欧蒂生物科技有限公司 | Health-caring capsules |
| CN102697927A (en) * | 2012-06-09 | 2012-10-03 | 李承平 | Cold-pungent tablet for resolving fleshy exterior |
| CN102988680A (en) * | 2012-10-16 | 2013-03-27 | 杨晓兵 | Preparation method of medicinal composition for tonifying kidney and spleen, preventing and treating osteoporosis |
| CN102988682A (en) * | 2012-10-16 | 2013-03-27 | 杨晓兵 | Oral liquid for tonifying kidney and spleen and preventing and treating osteoporosis |
| CN103461805B (en) * | 2013-08-18 | 2014-07-16 | 青岛福加德面粉有限公司 | Flour for osteoporosis patients to eat |
| CN103461805A (en) * | 2013-08-18 | 2013-12-25 | 青岛福加德面粉有限公司 | Flour for osteoporosis patients to eat |
| CN103585414A (en) * | 2013-11-16 | 2014-02-19 | 李伟丽 | Pharmaceutical composition for treating sciatica and osteoporosis |
| CN103656121A (en) * | 2013-12-06 | 2014-03-26 | 山东中大药业有限公司 | Immunity-improving traditional Chinese medicine composition and preparation method thereof |
| CN104771501A (en) * | 2014-01-09 | 2015-07-15 | 叶宗勲 | Traditional Chinese medicine composition used for preventing and treating alzheimer's disease |
| CN103860779A (en) * | 2014-03-14 | 2014-06-18 | 薛丹 | Traditional Chinese medicine for treating sciatica and preparation method thereof |
| CN104147409B (en) * | 2014-07-22 | 2016-11-23 | 竺妙飞 | One treats the yin asthenia generating intrinsic heat osteoporotic Chinese medicine of pattern of syndrome menopausal women |
| CN104225198A (en) * | 2014-09-29 | 2014-12-24 | 洛阳御平国生物科技有限公司 | Traditional Chinese medicine formula for treating hypermyotonia |
| CN104398802A (en) * | 2014-12-05 | 2015-03-11 | 李崇铭 | Traditional Chinese medicine preparation for strengthening spines and invigorating bones as well as preparation method thereof |
| CN104560581A (en) * | 2015-02-05 | 2015-04-29 | 彭正中 | Health wine for building bodies and preparation process of health wine |
| CN105125860A (en) * | 2015-10-23 | 2015-12-09 | 吴伶 | Preparation for effectively treating osteoporosis |
| CN106177437A (en) * | 2016-08-02 | 2016-12-07 | 北京天物四方生物科技有限公司 | A kind of improve the maca composition that women yang deficiency body is cold |
| CN106177437B (en) * | 2016-08-02 | 2020-03-27 | 北京天物四方生物科技有限公司 | Maca composition for improving yang deficiency and body cold of women |
| CN106237083A (en) * | 2016-08-31 | 2016-12-21 | 王捷 | The plant amedica compositions of yin-nourishing and health |
| CN110898089A (en) * | 2019-12-27 | 2020-03-24 | 西北工业大学 | Traditional Chinese medicine extract composition for treating osteoporosis |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101991716A (en) | New application of pharmaceutical composition of vital energy benefiting and smart decoction and the like in prevention and cure of osteoporosis | |
| CN102698137B (en) | Composition with blood pressure reducing function and preparation method of same | |
| CN101513437A (en) | Antifatigue Chinese pharmaceutical composition and preparation method thereof | |
| CN102085316A (en) | Medical composition with effect of tonifying spleen | |
| CN103690919A (en) | Medicine for treating piglet iron-deficiency anemia and preparation method of medicine | |
| CN104288644A (en) | Pharmaceutical composition for treating spleen deficiency and preparation method thereof | |
| CN104825914A (en) | Traditional Chinese medicinal preparation for assisted treatment of breast cancer | |
| CN104013789A (en) | Traditional Chinese medicine preparation for relaxing bowel and expelling toxin and preparation method thereof | |
| CN102178825B (en) | Healthcare medicine and method for processing healthcare medicine into medicament | |
| CN102038927A (en) | Pharmaceutical composition for preventing and treating climacteric metancholia and other diseases | |
| CN104740437A (en) | Traditional Chinese medicine composition for treating constipation and preparation method of traditional Chinese medicine composition | |
| CN101138597B (en) | Traditional Chinese medicine preparation for preventing and controlling osteoporosis and method of preparing the same | |
| CN104825855A (en) | Anti-ageing traditional Chinese medicinal composition and preparation method thereof | |
| CN106994141B (en) | Traditional Chinese medicine composition for treating constipation and preparation method thereof | |
| CN103520302B (en) | Sea-buckthorn leaf anti-fatigue capsule and preparation method thereof | |
| CN105232987A (en) | Traditional Chinese medicine promoting neurosurgery postoperative rehabilitation | |
| CN104958536A (en) | Chinese medicinal composition for treating diabetes and preparation method thereof | |
| CN104127683A (en) | Traditional Chinese medicine composition for treating or preventing female postmenopausal osteoporosis | |
| CN103040975B (en) | Traditional Chinese medicine composition for nursing and treating infantile diarrhea | |
| CN1285348C (en) | Breast enlarging composition and its preparing method | |
| CN107362301A (en) | Fragrant Siberian cocklebur appetizing particle | |
| CN104888091A (en) | Traditional Chinese medicine composition for treating intestinal form of acute radiation sickness and preparation method of traditional Chinese medicine composition | |
| CN105434933A (en) | Traditional Chinese medicine pill used for treating hot sweat symptom, and preparation method thereof | |
| CN105148164A (en) | Antai Buqi Chinese herbal medicament for livestock | |
| CN105727237A (en) | Folium artemisiae argyi-containing pharmaceutical composition for treating amenorrhea |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20110330 |