CN105434987A

CN105434987A - Traditional Chinese medicine preparation for treating cerebral infarction

Info

Publication number: CN105434987A
Application number: CN201511002090.9A
Authority: CN
Inventors: 杜小卫
Original assignee: Individual
Current assignee: Individual
Priority date: 2015-12-29
Filing date: 2015-12-29
Publication date: 2016-03-30

Abstract

The invention aims at providing a traditional Chinese medicine preparation for treating cerebral infarction. Flos carthami, angelica sinensis, radix rehmanniae praeparata, salviae miltiorrhizae, moutan bark, eclipta, dogwood, mulberries, cassia twig, marigold inflorescence, scorpio and flos magnolia are used for activating blood, removing stasis, inducing resuscitation with herbal aromatics, clearing and activating the channels and collaterals, tonifying the liver, benefiting the kidneys, improving blood circulation and dredging blood vessels as principal medicines and ministerial medicines; scabish, rhizoma atractylodis, liquorice, tortoise shell, poria cocos, bitter gourd, Chinese yam, garlic, celery, asparagus, coix leaves, radix angelicae, szechwan chinaberry fruits and rostrate lepidogrammitis herb are used for reinforcing the efficacies of the principal medicines and ministerial medicines as adjuvant medicines, and simultaneously have the efficacies of dispelling wind, dispersing heat, benefiting gallbladder, tonifying the spleen, warming meridians, promoting the circulation of qi, opening orifices and activating blood circulation; and a plurality of medicines are combined, are mild in medicine property and have the effect of treating the cerebral infarction.

Description

A kind of Chinese medicine preparation for the treatment of cerebral infarction

Technical field

The present invention relates to the field of Chinese medicines, specifically a kind of Chinese medicine preparation for the treatment of cerebral infarction.

Background technology

The blood of human body supply brain is blood vessel that 'go'gage is large to the little blood vessel of bore, finally arrives blood capillary.Therefore, when sclerosis occurs the tremulous pulse that bore is large, blood vessel wall can hardeningly thicken, be covered with harden plaque and thrombi in tube chamber, the existence of these things may not cause clinical symptoms and easily be ignored by people at ordinary times, once come off, more capillary vessel will be blocked, cause cerebral infarction.

1. main clinic symptoms

The clinical symptoms of cerebral infarction is complicated, its order of severity with encephaloclastic position, cerebral ischemia vessel size, ischemia, premorbid are with or without other diseases and relevant with or without merging other important organ diseases etc., the lighter can not have symptom completely, i.e. asymptomatic cerebral infarction; Also the quadriplegia or dizzy of recurrent exerbation can be shown as, i.e. transient ischemic attack; Severe one not only can have quadriplegia, even can acute coma, dead, as pathological changes affects cerebral cortex, can show as epilepsy at Acute Cerebrovascular Diseases, the highest with incidence rate in 1 day after being ill, is that starting cerebrovascular is then rare with epilepsy.Common symptom has:

(1) subjective symptom headache, dizzy, dizzy, dizzy, Nausea and vomiting, mobility and (or) sensory aphasia are even gone into a coma.

(2) cranial nerve symptom eyes stare to focus side, central facial palsy and tongue paralysis, pseudobulbar paralysis, as drinking-water is choked and coughed and dysphagia.

(3) somatization hemiplegia of limb or slight hemiplegia, hemihypoesthesia, instability of gait, limb adynamia, gatism etc.

2. cerebral infarction position clinical classification

(1) infarct size of lacunar infarct cerebral infarction is less than 1.5 millimeters, shows as: subacute onset, giddy, dizziness, instability of gait, limb adynamia, and minority has drinking-water to choke to cough, dysphagia; Also can have hemiplegia, hemihypoesthesia, some patients does not locate sign.

(2) moderate area infarction is fallen ill common with the other thalamus of basal nuclei district body of lateral ventricle, bilateral frontal lobe, temporal lobe district.Show as: sudden headache, dizzy, frequent Nausea and vomiting, conscious, inclined body paralysis or hemidysesthesia, hemianopsia, central facial palsy and tongue paralysis, pseudobulbar paralysis, aphasia etc.

(3) large area Infarction Patients onset is hurried, shows critical, can have hemianopsia hemiplegia, hemihypoesthesia even quadriplegia, cerebral hernia, stupor etc.

At present for one of the three major types disease causing human death cerebral infarction, the comprehensive treatment of employing has: 1, control blood pressure, cerebral; 2, volume expansion therapy; 3, medicament for expanding vascellum treatment; 4, thrombolytic therapy etc.Although these remedy measures can play good effect, but it is only for the acute attack stage of cerebral infarction, also the deterioration development of mitigate the disease is just controlled, although also have the therapeutic modalities such as some other logical bolt, operation, but Hazard ratio is larger, and by disease time, the pharmacy of the conditions such as the age body constitution of patient, and impracticable.

Summary of the invention

The object of this invention is to provide a kind of Chinese medicine preparation for the treatment of cerebral infarction, configured by clinic tests and repeated verification, meet the theory of Chinese medicine, we select natural animal-plant medicine to be raw material, utilize the comprehensive function treatment cerebral infarction of each taste Chinese medicine, without chemicals, harmless to human non-toxic, no matter state of an illness weight, all can take separately the medicine of the present invention, need not with other drug conbined usage, can reach healing object, and after the cured substance taken of patient, drug effect is sustainable to play a role, not easily recur, therapeutic effect is good.

The tcm causa morbi of cerebral infarction:

(1) just to decline long-pending damage: " Nian Sishi and half of YIN QI consumed, decline of vitality in daily life ".Old, or prolonged illness deficiency of both QI and blood, it is foster that first QI consumed appoints brain arteries and veins to lose.It is unable that the deficiency of vital energy then transports blood, thrombosis, and it is stagnant obstructed to cause the brain arteries and veins stasis of blood; Deficiency of YIN-blood is the moon sun not processed then, takes that expectorant is turbid, blood stasis disturbs key clearly, burst primary disease for interior pneumatic.Say as " Jing Yue's complete work ' non-wind ": " apoplectic stroke is many by decrepit and muddleheaded, this all internal injury amass declining and right.”

(2) overstrain internal injury: " yang-energy person, bothers, and opens ".Dun Lao is excessive, easily makes to rise, priming wind sun, endogenous wind turn, and gas fire is all floating, or doublely holds that expectorant is turbid under the arm, blood stasis disturbs key venation clearly.Because liver-yang is opened cruelly, vim and vigour are gushed apoplexy person suddenly, the state of an illness is multiple.

(3) dysfunction of the spleen in transportation, Phlegm to hinder collaterals: surfeit delicious food pure wine, causes taste injured, spleen loses transporting, the turbid interior life of expectorant, strongly fragrant interior-heat of a specified duration, and combination of phlegm and heat, stops up stagnant passages through which vital energy circulates, the clear key of upper illiteracy; Or ferritic liver-yang hyperactivity, mechanism of qi pent-up, gram cuts down spleen soil, the turbid interior life of expectorant; Or pathogenic fire derived from stagnation of liver-QI, bright Tianjin becomes expectorant, and phlegm stagnancy is tied mutually, takes the heresy of wind sun, harasses passages through which vital energy circulates, sends out as primary disease.This is that " hot air wind producing also for autochthonal expectorant, expectorant heat-dissipating for " danxi's experiential therapy apoplexy " what is called.”

(4) five will hindered, emotional stress: incoordination of seven emotions, and liver is lost bar and reaches, depression and stagnation of QI, hematogenous blockage, stasis brain arteries and veins; Rage, liver-yang is opened cruelly, or heart-fire is contained cruelly, fire and wind stirring up each other, and bleeding resulting from adverse flow of QI above offends brain.All this kind, all easily cause QI and blood to drive in the wrong direction, above disturb brain key and send out as apoplexy.Especially this patient is caused with rage the most common.

In addition, some scholars thinks that apoplexy has the occasioner because of exopathogen invasion and attack.As ailment said due to cold or exposure is taken advantage of a weak point in opponent's defence people's apoplex involving the channels and collaterals, QI and blood numbness hinders, and meat muscle arteries and veins loses supports in scholar; Or exopathogenic factor priming phlegm-damp, numbness resistance meridians, and cause out-of-the-way unsuccessful, this i.e. ancients' what is called " apoplexy ".

The common inducement of primary disease is: weather cataclysm, and bother excessively, feelings will is too drastic, tumbling down effort etc.

Take a broad view of primary disease, due to patient's visceral dysfunction, or QI and blood element is empty, in addition overstrain internal injury, be worried angry, drink be satiated with food, overexertion, and cause stagnation of blood stasis, accumulation of phlegm-heat in the interior, or positive wind-transformation is dynamic, blood stasis leading to QI-adverseness, cause brain BI-syndrome involved the blood vessels to hinder or outside blood oozing from the body openings or subcuta neous tissue brain feeling pulse, cause dusk to fall forward unsuccessful, sending out as apoplexy.Its sick position is at brain, closely related with the heart, kidney,liver,spleen.General and the opinion of its pathogenesis have void (deficiency of YIN, yang deficiency), fiery (liver-fire, heart-fire), wind (liver-wind, exogenous wind), expectorant (wind-phlegm, damp-phlegm), gas (deficiency of vital energy, QI rising in reverse order), blood (blood stasis) six end, six ends is many influences each other under certain condition for these, interacts.Characteristic of disease mostly is deficiency in origin and excess in superficiality, upper excess and lower deficiency.Originally be the hepatic and renal YIN deficiency, QI and blood declines few, is being designated as fire and wind stirring up each other, and phlegm-damp resistance network, stagnation of blood stasis, QI and blood is disorderly inverse.And its basic pathogenesis to be QI and blood inverse disorderly, on violate in brain.

We with Flos Carthami, Radix Angelicae Sinensis, Radix Rehmanniae Preparata, Radix Salviae Miltiorrhizae, Cortex Moutan, Herba Ecliptae, Fructus Corni, Fructus Mori, Ramulus Cinnamomi, Flos Tagetis Erectae inflorescence, Scorpio, Flos Magnoliae be the monarch and his subjects medicine blood circulation promoting and blood stasis dispelling, causing resuscitation with aromatic drugs, dredge the meridian passage, the liver and the kidney tonifying, improve blood circulation, dredging vascellum; With Radix Oenotherae erythrosepalae, Rhizoma Atractylodis, Radix Glycyrrhizae, Carapax Et Plastrum Testudinis, Poria, Fructus Momordicae charantiae, Rhizoma Dioscoreae, Bulbus Allii, Herba Apii graveolentis, Germinatus Phragmitis, Folium Coicis, the Radix Angelicae Dahuricae, Fructus Toosendan, the medicine of Herba Lepidogrammitis rostratae for assisting a ruler in governing a country, strengthen effect of the medicine of the monarch and his subjects, also there is wind-dispelling heat-dissipating, function of gallbladder promoting spleen invigorating, warming the meridian circulation of qi promoting, sensible effect of invigorating blood circulation simultaneously, all medicines share, medicine warm and, have treatment cerebral infarction effect.

Treat a Chinese medicine preparation for cerebral infarction, it is characterized in that, be made up of the raw material of following weight portion:

Flos Carthami 10-20 part, Radix Angelicae Sinensis 10-20 part, Radix Rehmanniae Preparata 10-20 part, Radix Salviae Miltiorrhizae 10-20 part, Cortex Moutan 10-20 part, Herba Ecliptae 10-20 part, Fructus Corni 10-20 part, Fructus Mori 10-20 part, Ramulus Cinnamomi 10-20 part, Flos Tagetis Erectae inflorescence 10-20 part, Scorpio 10-20 part, Flos Magnoliae 10-20 part, Radix Oenotherae erythrosepalae 10-20 part, Rhizoma Atractylodis 10-20 part, Radix Glycyrrhizae 10-20 part, Carapax Et Plastrum Testudinis 10-20 part, Poria 10-20 part, Fructus Momordicae charantiae 10-20 part, Rhizoma Dioscoreae 10-20 part, Bulbus Allii 10-20 part, Herba Apii graveolentis 10-20 part, Germinatus Phragmitis 10-20 part, Folium Coicis 10-20 part, Radix Angelicae Dahuricae 10-20 part, Fructus Toosendan 10-20 part, Herba Lepidogrammitis rostratae 10-20 part,

Preparation method process of the present invention is:

By formula proportion by after the sorting of all medicines routine → dry → be crushed to 300-400 order fine powder → mix homogeneously → incapsulate.

Flos Carthami 12-18 part, Radix Angelicae Sinensis 12-18 part, Radix Rehmanniae Preparata 12-18 part, Radix Salviae Miltiorrhizae 12-18 part, Cortex Moutan 12-18 part, Herba Ecliptae 12-18 part, Fructus Corni 12-18 part, Fructus Mori 12-18 part, Ramulus Cinnamomi 12-18 part, Flos Tagetis Erectae inflorescence 12-18 part, Scorpio 12-18 part, Flos Magnoliae 12-18 part, Radix Oenotherae erythrosepalae 12-18 part, Rhizoma Atractylodis 12-18 part, Radix Glycyrrhizae 12-18 part, Carapax Et Plastrum Testudinis 12-18 part, Poria 12-18 part, Fructus Momordicae charantiae 12-18 part, Rhizoma Dioscoreae 12-18 part, Bulbus Allii 12-18 part, Herba Apii graveolentis 12-18 part, Germinatus Phragmitis 12-18 part, Folium Coicis 12-18 part, Radix Angelicae Dahuricae 12-18 part, Fructus Toosendan 12-18 part, Herba Lepidogrammitis rostratae 12-18 part,

15 parts, Flos Carthami, Radix Angelicae Sinensis 15 parts, Radix Rehmanniae Preparata 15 parts, Radix Salviae Miltiorrhizae 15 parts, Cortex Moutan 15 parts, Herba Ecliptae 15 parts, Fructus Corni 15 parts, 15 parts, Fructus Mori, Ramulus Cinnamomi 15 parts, Flos Tagetis Erectae inflorescence 15 parts, Scorpio 15 parts, Flos Magnoliae 15 parts, Radix Oenotherae erythrosepalae 15 parts, Rhizoma Atractylodis 15 parts, 15 parts, Radix Glycyrrhizae, Carapax Et Plastrum Testudinis 15 parts, 15 parts, Poria, 15 parts, Fructus Momordicae charantiae, Rhizoma Dioscoreae 15 parts, 15 parts, Bulbus Allii, Herba Apii graveolentis 15 parts, Germinatus Phragmitis 15 parts, Folium Coicis 15 parts, the Radix Angelicae Dahuricae 15 parts, Fructus Toosendan 15 parts, Herba Lepidogrammitis rostratae 15 parts;

Soup potus preparation method of the present invention is specially:

Each component is pulverized respectively, be mixed in proportion, obtain mixture, add water to and flood mixture powder 3 ~ 5cm, soak 1 ~ 2 hour, heating decocts, boil rear slow fire, decoct 2 ~ 4 hours after boiling for the first time, leach medicinal liquid, again add water in filtering residue and flood mixture powder 3 ~ 5cm, heated and boiled, boils rear slow fire, and second time decocts 1 ~ 2 hour after boiling, filter, merge the medicinal liquid of twice filtration, centrifugal 30 minutes ~ 1 hour, extract supernatant, being concentrated into crude drug concentration is 1g/ml ~ 2g/ml, obtains soup potus.

Injection preparation of the present invention is specially:

Each component is pulverized respectively, be mixed in proportion, obtain mixture, add water to and flood mixture powder 3 ~ 5cm, soak 1 ~ 2 hour, heating decocts, boil rear slow fire, first time decocts 2 ~ 4 hours after boiling, leach medicinal liquid, again add water in filtering residue and flood mixture powder 3 ~ 5cm, heated and boiled, boil rear slow fire, second time decocts 1 ~ 2 hour after boiling, filter, merge the medicinal liquid of twice filtration, add and account for quality of liquid medicine 0.5% active carbon, keep pH value 7.0, heat micro-boiling 15 minutes, cooling, filter, get 500ml filtrate, inject water to 1000ml, packed, in 115 DEG C of sterilizings 30 minutes, cold preservation 48 hours, obtain injection.

The present invention relates to pharmacology and the property of medicine of Chinese medicine:

Flos Carthami:

[nature and flavor] are warm in nature, acrid in the mouth.

[function cures mainly] invigorates blood circulation latus rectum, eliminating stasis to stop pain.For amenorrhea, dysmenorrhea, lochia, lump in the abdomen mass in the abdomen, traumatic injury, be suitable for various varicosis, peripheral neuritis, blood circulation, lower limb numbness or the congestion such as livid purple.

Radix Angelicae Sinensis:

[nature and flavor] are warm in nature, hide sweet, pungent.

[function cures mainly] is enriched blood and is invigorated blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.For blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.

Radix Rehmanniae Preparata:

[meridian distribution of property and flavor] is sweet, tepor; Return liver, kidney channel.

[function cures mainly] nourishing YIN and supplementing blood, beneficial essence fills out marrow.For the hepatic and renal YIN deficiency, soreness of the waist and knees, osteopyrexia and fever, night sweat is passed out semen, and interior-heat is quenched one's thirst, blood deficiency and yellow complexion, severe palpitation, menoxenia, and metrostaxis is dizzy, tinnitus, early whitening of beard and hair.

Radix Salviae Miltiorrhizae:

[meridian distribution of property and flavor] cold nature, bitter in the mouth.

[effect] has the function of calming the nerves, living blood stasis and tissue regeneration promoting blood.

Cortex Moutan: Paeonia suffruticosa not only has ornamental value, but also there is very high medical value.Being processed into " Cortex Moutan " by the root of Paeonia suffruticosa, is famous and precious Chinese herbal medicine.Its cold nature, acrid in the mouth, nontoxic, enter the heart, liver, kidney three warp, have dissipating blood stasis blood, purify the blood and blood, pain relieving, the effect of stimulating the menstrual flow, reduce blood pressure in addition, effect of anti-inflammation, clothes can be lengthened the life by beneficial body for a long time.Nourish blood regulating liver-QI, loose strongly fragrant blood stasis dispelling, is applicable to chloasma faciei, skin aging, and normal drink QI and blood is lived lung, and appearance is ruddy, improves menoxenia, dysmenorrhea, only sweating due to debility, night sweat.

Herba Ecliptae:

[meridian distribution of property and flavor] is sweet, sour, cold.Return kidney, Liver Channel.1. Tang Materia Medica: " sweet in the mouth acid, flat, nontoxic." 2. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " and cold in nature, salty in the mouth." enter liver, kidney channel.1. " Bencao Jingshu ": " enter kidney, liver.Stomach, intestine and small intestine." 2. " must book on Chinese herbal medicine be joined ": " enter meridian of Foot-SHAO YIN blood system.”

[function cures mainly] nourishing the liver and kidney, cooling blood for hemostasis.For odontoseisis, early whitening of beard and hair, vertigo and tinnitus, the acid of waist knee joint, YinXuXueRe, haematemesis, blood nosebleed, hematuria, dysentery, metrostaxis, traumatic hemorrhage.

Fructus Corni: property is flat, sweet in the mouth, acid, function nourishing the liver and kidney, astringing YIN to stop sweating emergency treatment of collapse, is nourishing kidney yin key medicine, is mainly used in syndrome of yin deficiency of liver and kidney, is applicable to the soreness of the waist and knees caused by Liver and kidney two void, vertigo and tinnitus, sexual impotence, seminal emission, frequent micturition, the diseases such as incessant sweating due to debility.

Fructus Mori:

[nature and flavor] are sweet, are slightly cold; GUIXIN, liver, kidney channel.

[function cures mainly] controls hepatic and renal YIN deficiency, sends and takes off, constipation, and order is dark, tinnitus, former infections, articular instability.It is improved skin (comprising scalp) blood supply, nutrition skin, makes the effects such as the delicate and black hair of skin, and can slow down aging.Fructus Mori is that middle-aged and elderly people is healthy and strong U.S. face, antidotal good fruit and good medicine.Normal food Fructus Mori can improving eyesight, the symptom that relieving eye strain is dry and astringent.Fructus Mori has immunologic enhancement.Fructus Mori has effect of gain to spleen, has potentiation to hemolytic reaction, can prevent human body artery sclerosis, skeletal joint sclerosis, enhance metabolism; Fructus Mori can promote the growth of erythrocyte, prevents leukopenia, and has auxiliary curative effect to diseases such as treatment diabetes, anemia, hypertension, hyperlipidemia, coronary heart disease, neurasthenias.Fructus Mori has the effects such as promoting the production of body fluid to quench thirst, facilitating digestion, help defecation, and proper amount of edible can promote gastric secretion, stimulates enterokinesia and removes scorching.The traditional Chinese medical science is thought, Fructus Mori is sweet in flavor and cold in property, there is the liver and the kidney tonifying, intestine moistening of promoting the production of body fluid, the effect such as black hair improving eyesight.

Ramulus Cinnamomi:

[meridian distribution of property and flavor] taste acrid, sweet, warm.GUIXIN, lung, urinary bladder channel.

[function cures mainly] diaphoresis expelling pathogenic factors from muscles, promoting the flow of QI-blood by warming the meridian, supporing yang activating QI, the flat gas that spins.For anemofrigid cold, coldness and pain in the epigastrium, cold in blood amenorrhea, arthralgia, phlegm retention, edema, cardiopalmus, renal mass.

Flos Tagetis Erectae inflorescence: bitter, cool.Suppressing the hyperactive liver is antipyretic, dispelling pathogenic wind and eliminating phlegm.For having a dizzy spell, wind syndrome of head ophthalmalgia, infantile convulsion, cold cough, pertussis, mastalgia, mumps.

Scorpio:

[meridian distribution of property and flavor] acrid in the mouth is flat; Poisonous; Return Liver Channel.

[function cures mainly] endogenous wind stopping spasmolytic, dispersing pathogen accumulation, removing obstruction in the collateral to relieve pain.For infantile convulsion, tic spasm, middle air port is askew, hemiplegia, tetanus, rheumatoid arthritis stubborn, migraine and general headache, skin infection, scrofula.

Flos Magnoliae:

[nature and flavor] are pungent, temperature.1. " herbal classic ": acrid in the mouth, temperature.2. " not Lu ": nontoxic.3. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": warm in nature, the micro-hardship of acrid in the mouth.

[return through] enters lung, stomach warp.1. " detailed outline ": lunar, Foot yangming Channel of starting with.2. " book on Chinese herbal medicine is newly organized ": enter lung, gallbladder two warp.3. " book on Chinese herbal medicine is new again ": enter spleen, lung two warp.4. " book on Chinese herbal medicine brief points ": enter meridian of Foot-JUE YIN.

[function cures mainly] dispels the wind, sensible.Control headache, nasal sinusitis, have a stuffy nose obstructed, toothache.1. " herbal classic ": main the five internal organs health cold and heat, public attention headache, face acid anhydride.2. " not Lu ": warming middle-JIAO expelling pathogenic factors from muscles, sharp nine orifices, stuffy nose relieving plug, tears go out, and control swelling of the face and draw toothache, and dizziness, body are several as person on car and boat.Raw beard and hair, removes tapeworm.3. " property of medicine opinion ": can acid anhydride of looking unfamiliar be controlled.Face fat use, key light China.4. " Japan hanako materia medica ": clearance arteries and veins, improving eyesight.Control headache, the loathing of cold, body kept silent, pruritus.5. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": control sinusitis with purulent discharge nasal sinusitis, dispel the wind, new watt of roasting is end.The cold pain in face of controlling, peratodynia, heat spills clothes.6. " detailed outline ": nasal abscess after nasal sinusitis, allergic rhinitis, stuffy nose, nasal abscess and pox, and with grinding into powder, enter Moschus a little, Bulbus Allii Fistulosi is dipped into for several times.7. " beautiful Chinese catalpa medicine solution ": let out lung sending down the abnormal ascending QI, promoting the circulation of QI is broken stops up.8. " Jiangxi Chinese medicine ": external can promote uterine contraction, and tool expedites the emergence of effect.

Radix Oenotherae erythrosepalae:

[nature and flavor] are warm in nature, sweet in the mouth.

[function] has the function of bone and muscle strengthening, expelling wind and removing dampness, is used for the treatment of rheumatism, the diseases such as bones and muscles pain.Its seed first can obtain gamma-Linolenic acid through oil expression, saponification, acidify, as raw material, transform through chemical constitution, PGE1 can be obtained again through biosynthesis, it is antithrombotic, expands blood vessel new drug, is widely used in thromboangiitis, chronic arteria occlusion disease, myocardial infarction, central vein of retina thrombosis angiography, reconstructing blood vessel radiography etc.

Rhizoma Atractylodis:

[nature and flavor] are warm in nature, acrid in the mouth, hardship,

[function] eliminating turbid pathogen with aromatics, dispeling the wind, it is dirty to ward off, drying damp and strengthening spleen, is applicable to gastral cavilty vexed, and the large loose stool of abdominal distention is soft, vomiting and nausea, extremity asthenia, and seasonal epidemic pathogens is caught a cold, all diseases of abundant expectoration.

Radix Glycyrrhizae:

[meridian distribution of property and flavor] is sweet, flat, GUIXIN, lung, spleen, stomach warp;

[function cures mainly] invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.

Carapax Et Plastrum Testudinis:

[meridian distribution of property and flavor] is salty, sweet, is slightly cold.Return liver, kidney, heart channel.

[function cures mainly] nourishing YIN for suppressing the hyperactive YANG, kidney tonifying bone strengthening, reinforcing the heart of nourishing blood.For deficiency of YIN hectic fever, hectic fever due to YIN-deficiency night sweat, has a dizzy spell, stirring-up of pathogenic wind in the interior resulting from deficiency, and muscles and bones flaccidity is soft, has a guilty conscience forgetful.

Poria:

[nature and flavor] sweet in the mouth, light, flat; GUIXIN, lung, spleen, kidney channel.

[function cures mainly] promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming; For edema oliguria, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in loose stool, irritability, palpitation with fear insomnia.

Fructus Momordicae charantiae:

[meridian distribution of property and flavor] is bitter, cold.Return spleen, stomach, the heart, Liver Channel.

[effect] heat clearing away is dispelled heart-fire, removing toxic substances, improving eyesight, and QI invigorating benefit essence, quenches the thirst and relieve summer heat, control carbuncle.

Rhizoma Dioscoreae:

[nature and flavor] sweet in the mouth, property are flat, enter lung, spleen, kidney channel;

[function cures mainly] has strengthening the spleen and tonifying the lung, stomach reinforcing the kidney invigorating, benefit of reinforcing the kidney essence, hearing-improing and eyesight improving, help the five internal organs, bone and muscle strengthening, long will are calmed the nerves, effect of life lengthening; Cure mainly that weakness of the spleen and stomach, lassitude, inappetence, chronic diarrhea and dysentery, insufficiency of lung-QI are dry, phlegm dyspnea cough, kidney qi loss, soreness of the waist and knees, lower limb flaccidity be weak, the red disease such as swollen, fat of frequent micturition of quenching one's thirst, seminal emission premature ejaculation, leukorrhagia nebulousurine, skin.

Bulbus Allii:

[meridian distribution of property and flavor] is warm in nature, and acrid in the mouth is put down; People's spleen, stomach, lung meridian.

[function cures mainly] has loose bowels for dysentery, pulmonary tuberculosis. pertussis, intestinal parasitic disease (ancylostome, enterobiasis), the diseases such as sore and toxic.1. loose carbuncle removing food stagnancy, removing toxic substances parasite killing: cure mainly carbuncle sore tumefacting virus, tinea skin ulcer pruritus.Mash external application or the outer wiping of section.2. detoxify: for pulmonary tuberculosis pertussis, dysentery is had loose bowels.3. parasite killing: for ancylostomiasis, around parasitosis, can join the same decoction of anthelmintic.To ancylostomiasis, this product also can do prevention, before work of going to the field, is mashed by Bulbus Allii, is applied to extremity.Opposing connection parasitosis, also can mash this product, adds vegetable oil a little, is applied to perianal just before going to bed.In addition, this product is eaten raw and also can be prevented and treated influenza.

Herba Apii graveolentis:

[nature and flavor] sweet in the mouth is pungent, nontoxic

[function] has and has calming liver and clearing heat, expelling wind and removing dampness, and relieving restlessness is subsided a swelling, cooling blood for hemostasis, removing toxic substances lung qi dispersing, stomach invigorating profit blood, bowel relieving is convenient, nourishing the lung to arrest cough, reduce blood pressure, effect of brain-strengthening calmness.Often eat Herba Apii graveolentis, especially eat leaf of Herba Apii graveolentis, all very useful to prophylaxis of hypertension, arteriosclerosis etc., and have auxiliary therapeutic action.

Germinatus Phragmitis:

[pharmacology value] 1, contribute to stabilizing blood pressure blood fat reducing; 2, contribute to suppressing cardiovascular disease; 3, contribute to prevention and anticancer; 4, contribute to control senile constipation, diuresis to recover from fatigue; 5, contribute to suppressing and resisting viral bacterium; 6, health invigorating allaying tiredness is contributed to.

[nutritive value] 1, homovitamin, high-cellulose, high protein 2, low sugar, low fat 3, a great number of elements containing multiple needed by human and trace element

[effect] 1, cancer-resisting effect, can suppress topoisomerase active, directly kill cancerous cell, destruction of cancer cells telomerase, makes cancerous cell can not multiple fission and wither it, activates antioncogene adjustment signal, transfer cell growth normalization.2, to the therapeutical effect of cardiovascular disease, Germinatus Phragmitis can suppress hypertension, prevents sclerosis of blood vessels, reduces blood fat and cholesterol.3, on the impact of human immune system, Germinatus Phragmitis can reduce circulating immune complex CIC content, can produce thymosin, promotes the generation of T cell, thus improves immunologic function, immunity moderation mechanism.4, the effect in defying age can reduce the lipid peroxide of human organ, the content of LOP, improves the activity of superoxide dismutase SOD thus slow down aging.

Folium Coicis:

[collection] summer, autumn take.

[chemical composition] leaf is containing alkaloid.

[function cures mainly-Folium Coicis effect]

1. " Bencao Tujing ": for drinking perfume (or spice), beneficial hollow diaphragm.

2. " trifling record ": the summer-heat moon decocts drink, warming the stomach, replenishing QI and blood.

There is effect of warming spleen and stomach for dispelling cold, benefiting vital QI and blood, cure mainly cold syndrome of the stomach pain, the symptom of deficient qi and blood.

The Radix Angelicae Dahuricae:

[nature and flavor] are pungent, and temperature enters lung, spleen, stomach warp;

[effect] controls headache, supraorbital bone pain, toothache, and cold-damp is suffered from abdominal pain, skin pruritus, scabies.Expelling wind and cold, understand things pain-stopping, evacuation of pus of invigorating blood circulation, granulation promoting pain relieving, dampness leukorrhagia stopping.For mastalgia, swell and ache, have a headache, have a toothache, nasal sinusitis, hemorrhoidal hamorrhage anal fistula, leucorrhea with red and white discharge, ulcer sores, skin pruritus.Modern pharmacological research proves that the Radix Angelicae Dahuricae also has antiinflammatory, antipyretic-antalgic, active eliminating stagnation, can be used for controlling the effects such as mammary gland caking with other Chinese Medicine and Clavicular.

Fructus Toosendan has another name called Fructus Toosendan:

[nature and flavor] are cold in nature, bitter in the mouth,

[function] is the one of qi-activating drug; Mainly enter Liver Channel, catharsis liver-heat, promoting the circulation of QI to relieve pain, have the function except damp and hot, clearing away liver-fire, pain relieving, parasite killing.But also be make efficiently without the important source material of residual hazard free of contamination novel plant class pesticide.

Herba Lepidogrammitis rostratae:

[nature and flavor] micro-hardship; Sweet; Flat

[return through] lung; Small intestine meridian

[function cures mainly] clearing away heat and promoting diuresis; Cough-relieving; Relieving restlessness; Removing toxic substances and promoting subsidence of swelling.Main uroschesis; Drench the puckery pain of drop; Heat syndrome cough; Vexed; Skin infection swells and ache; Traumatic injury.

Detailed description of the invention:

Embodiment 1, formula:

Flos Carthami 10g, Radix Angelicae Sinensis 10g, Radix Rehmanniae Preparata 10g, Radix Salviae Miltiorrhizae 10g, Cortex Moutan 10g, Herba Ecliptae 10g, Fructus Corni 10g, Fructus Mori 10g, Ramulus Cinnamomi 10g, Flos Tagetis Erectae inflorescence 10g, Scorpio 10g, Flos Magnoliae 10g, Radix Oenotherae erythrosepalae 10g, Rhizoma Atractylodis 10g, Radix Glycyrrhizae 10g, Carapax Et Plastrum Testudinis 10g, Poria 10g, Fructus Momordicae charantiae 10g, Rhizoma Dioscoreae 10g, Bulbus Allii 10g, Herba Apii graveolentis 10g, Germinatus Phragmitis 10g, Folium Coicis 10g, Radix Angelicae Dahuricae 10g, Fructus Toosendan 10g, Herba Lepidogrammitis rostratae 10g;

Preparation method process of the present invention is:

Instructions of taking: each 2, every day twice, every 0.25g, warm water takes.

Embodiment 2, formula:

Flos Carthami 12g, Radix Angelicae Sinensis 12g, Radix Rehmanniae Preparata 12g, Radix Salviae Miltiorrhizae 12g, Cortex Moutan 12g, Herba Ecliptae 12g, Fructus Corni 12g, Fructus Mori 12g, Ramulus Cinnamomi 12g, Flos Tagetis Erectae inflorescence 12g, Scorpio 12g, Flos Magnoliae 12g, Radix Oenotherae erythrosepalae 12g, Rhizoma Atractylodis 12g, Radix Glycyrrhizae 12g, Carapax Et Plastrum Testudinis 12g, Poria 12g, Fructus Momordicae charantiae 12g, Rhizoma Dioscoreae 12g, Bulbus Allii 12g, Herba Apii graveolentis 12g, Germinatus Phragmitis 12g, Folium Coicis 12g, Radix Angelicae Dahuricae 12g, Fructus Toosendan 12g, Herba Lepidogrammitis rostratae 12g;

Preparation method is identical with embodiment 1.

Embodiment 3, formula:

Flos Carthami 15g, Radix Angelicae Sinensis 15g, Radix Rehmanniae Preparata 15g, Radix Salviae Miltiorrhizae 15g, Cortex Moutan 15g, Herba Ecliptae 15g, Fructus Corni 15g, Fructus Mori 15g, Ramulus Cinnamomi 15g, Flos Tagetis Erectae inflorescence 15g, Scorpio 15g, Flos Magnoliae 15g, Radix Oenotherae erythrosepalae 15g, Rhizoma Atractylodis 15g, Radix Glycyrrhizae 15g, Carapax Et Plastrum Testudinis 15g, Poria 15g, Fructus Momordicae charantiae 15g, Rhizoma Dioscoreae 15g, Bulbus Allii 15g, Herba Apii graveolentis 15g, Germinatus Phragmitis 15g, Folium Coicis 15g, Radix Angelicae Dahuricae 15g, Fructus Toosendan 15g, Herba Lepidogrammitis rostratae 15g;

Preparation method is identical with embodiment 1.

Embodiment 4, formula:

Flos Carthami 18g, Radix Angelicae Sinensis 18g, Radix Rehmanniae Preparata 18g, Radix Salviae Miltiorrhizae 18g, Cortex Moutan 18g, Herba Ecliptae 18g, Fructus Corni 18g, Fructus Mori 18g, Ramulus Cinnamomi 18g, Flos Tagetis Erectae inflorescence 18g, Scorpio 18g, Flos Magnoliae 18g, Radix Oenotherae erythrosepalae 18g, Rhizoma Atractylodis 18g, Radix Glycyrrhizae 18g, Carapax Et Plastrum Testudinis 18g, Poria 18g, Fructus Momordicae charantiae 18g, Rhizoma Dioscoreae 18g, Bulbus Allii 18g, Herba Apii graveolentis 18g, Germinatus Phragmitis 18g, Folium Coicis 18g, Radix Angelicae Dahuricae 18g, Fructus Toosendan 18g, Herba Lepidogrammitis rostratae 18g;

Soup potus preparation method is specially:

Instructions of taking: every day twice, each little bowl, warmly takes.

Embodiment 5, formula:

Flos Carthami 20g, Radix Angelicae Sinensis 20g, Radix Rehmanniae Preparata 20g, Radix Salviae Miltiorrhizae 20g, Cortex Moutan 20g, Herba Ecliptae 20g, Fructus Corni 20g, Fructus Mori 20g, Ramulus Cinnamomi 20g, Flos Tagetis Erectae inflorescence 20g, Scorpio 20g, Flos Magnoliae 20g, Radix Oenotherae erythrosepalae 20g, Rhizoma Atractylodis 20g, Radix Glycyrrhizae 20g, Carapax Et Plastrum Testudinis 20g, Poria 20g, Fructus Momordicae charantiae 20g, Rhizoma Dioscoreae 20g, Bulbus Allii 20g, Herba Apii graveolentis 20g, Germinatus Phragmitis 20g, Folium Coicis 20g, Radix Angelicae Dahuricae 20g, Fructus Toosendan 20g, Herba Lepidogrammitis rostratae 20g;

Injection preparation of the present invention is specially:

Pharmacology pharmacodynamic is tested:

1, acute toxicity test

Application mice carries out acute toxicity testing and shows: Mouse oral gavage Chinese medicine preparation of the present invention, under 488.8g crude drug/kg dosage, after administration, mice occurs that light activity reduces, 1 hours recovers normal, Continuous Observation 7 days after administration, none animal dead, its overall health of patients, diet, take the photograph water, urine and body weight increase all normal, experimental result shows: the maximum dosage-feeding of Mouse oral gavage Traditional Chinese medicine preparation capsule agent of the present invention is 488.8g crude drug/kg/d (LD50 > 488.8g crude drug/kg).Chinese medicine preparation clinical application every day total amount of the present invention is 0.1g crude drug/kg/d; By weighing machine, the dosis tolerata of mouse stomach Chinese medicine preparation of the present invention is 4888 times of clinical patient.Point out this medicine acute toxicity low, clinical drug safety.

2, long term toxicity test

Select SD rat, give the Chinese medicine preparation of the present invention of variable concentrations (18.0,6.0,2.0g crude drug/kg), every day gavage once, continuous 90 days, within after last administration 24 hours, respectively group is alive kills 1/2 animal (male and female half and half), and all the other 1/2 animals continue observations 2 weeks rear living and kill.Duration of test observes outward appearance, general behavior, food ration, the body weight change of animal, within after administration 90 days, within 2 weeks, carries out the index checking such as hematology's (RBC, HB, reticulocyte, PLT, CT, WBC and classification) and blood biochemical (AST, ALT, ALP, Glu, BUN, Crea, TP, T.BIL, ALB, CHOL), urine biochemistry, organ coefficient, histopathology with drug withdrawal.Result of the test shows: invention formulation is good at high, medium and low dosage treated animal general state, and outward appearance sign, behavioral activity, food-intake and body weight increase change all without exception; Three dosage groups and matched group hematological examination, blood biochemical analysis, urine biochemical analysis all in normal range, without significant difference between group; Each group of main organs histopathological examination shows no obvious abnormalities.These parameters drug withdrawal also had no change after 2 weeks.This test dosage is respectively 180,60,20 times of clinical medicine dose, rat is had no significant effect in high, medium and low three dosage (18.0,6.0,2.0g crude drug/kg) administration in continuous 90 days according to result of the test Chinese medicine preparation of the present invention, without clear and definite toxicity target organ and sensitive indicator, convalescent period observation also has no retardance toxic reaction, points out the dose safety of Chinese medicine preparation clinical practice of the present invention higher.

3, animal local excitation test:

The allergic reaction on guinea pigs of invention formulation and Rat-rectum medication irritation test.Result shows: skin anaphylactic test, high dose group 0.8g (medicated powder)/kg, low dose group 0.1g (medicated powder)/kg, be equivalent to 20 times, 2.5 times that intend clinical people's consumption [0.04g (medicated powder)/kg] respectively, through percutaneous drug delivery, be showed no animal and produce allergy; Rectal application irritation test high dose group 5.0g (medicated powder)/kg, low dose group 3.2g (medicated powder)/kg, be equivalent to 125,80 times that intend clinical people's consumption respectively, mucous membrane of rectum is observed all without phenomenons such as hyperemia, edema in official hour, histopathologic examination compares no significant difference with blank group, have no and occur obvious irritative response, often organize its overall health of patients of Some Animals of retention, body weight, breathing, circulation, central nervous system and extremity are movable, equal Non Apparent Abnormality reaction.

The observation of curative effect for the treatment of cerebral infarction

Cerebral infarction, according to clinical statistics, we adopted homemade traditional Chinese drug prescription treatment case 1000 many cases in 2012-2015, obtained good result, were now summarized as follows.

Diagnostic criteria:

Suddenly faint with patient, syncope, occur together facial hemiparalysis, dysphonia, hemiplegia or faint and occur suddenly hemiplegia or partially body is unable, the symptoms such as hemidysesthesia, aphasia, monocular vision obstacle, engage the display of brain CT examination feature, low-density shadow, as pathological changes, both can be made a definite diagnosis.

Typical clinical case inclusion criteria:

Inclusion criteria: there is typical clinical manifestation, meet diagnostic criteria.

MethodsThe cases enrolled 600 example, wherein male 380 example. women 220 example.

Efficacy determination: adopt 4 grade standards

Curative effect judging standard (pressing limbs change):

1, invalid: to show as and collapse from physical exhaustion, limbs do not have motor function.

2, effective: limb function starts to recover, and occurs faint voluntary movement, muscle spasm and some is rudimentary not with motion.

3, effective: muscle spasm starts to alleviate, some when comparatively compound movement is initial study have any problem, then then become easily or can learn the more difficult motion be comparatively responsible for.

4, fully recover: muscle spasm disappears, and the various motions in each joint can be carried out, motor coordination function is close to normal.

Clinical statistics is summarized as follows:

Recovery from illness clinical improvements rate >=95%; Effective clinical improvements rate < 95%, >=60%;

Effective clinical improvement rate < 60%, >=20%; Invalid clinical improvements rate < 20%.

Model case:

Case 1:

After Wang examines: take medicine-feeding after 10 days, defecate 2 times/day, diet increases, and abdominal distention is aobvious to be subtracted, spirit comparatively before good, speak obviously clear comparatively, face is more existing red, and not bitterly, two lower limb pneumonedema, upper right abdominal pressure pain is aobvious to be subtracted gingiva, yellow and greasy fur, thready and hesitant pulse.Medicine in, no more side effects, still with top, after 20 days rehabilitation recovery from illness.

Case 2:

After Liu examines: after taking medicine 10 days, spirit is clearly better, face is existing red, receives increasings that continue, and walk fast strong comparatively, steady comparatively, speak normally, the softness of upper right abdominal pressure, gingiva is bitterly slightly not red, and lower limb are micro-to swell, yellow and greasy fur of defecating, thready and hesitant pulse.Medicine in, no more side effects, still with top, after 20 days rehabilitation recovery from illness.

Case 3:

After Zhang examines: after taking medicine 10 days, language is clear, normally, stool day 1 time, slightly unfavorable, whole body is not stranded diet, walks fast than my old man and steady, without festination, but the oriented preshoot sense of descending; Full abdomen is substantially soft, and resistance strengthens, and seldom catch a cold, patient body recovers normally, to add and subtract 3 doses to consolidate it, check recovery from illness after 20 days with top substantially.

Claims

1. treat a Chinese medicine preparation for cerebral infarction, it is characterized in that, be made up of the raw material of following weight portion:

Flos Carthami 10-20 part, Radix Angelicae Sinensis 10-20 part, Radix Rehmanniae Preparata 10-20 part, Radix Salviae Miltiorrhizae 10-20 part, Cortex Moutan 10-20 part, Herba Ecliptae 10-20 part, Fructus Corni 10-20 part, Fructus Mori 10-20 part, Ramulus Cinnamomi 10-20 part, Flos Tagetis Erectae inflorescence 10-20 part, Scorpio 10-20 part, Flos Magnoliae 10-20 part, Radix Oenotherae erythrosepalae 10-20 part, Rhizoma Atractylodis 10-20 part, Radix Glycyrrhizae 10-20 part, Carapax Et Plastrum Testudinis 10-20 part, Poria 10-20 part, Fructus Momordicae charantiae 10-20 part, Rhizoma Dioscoreae 10-20 part, Bulbus Allii 10-20 part, Herba Apii graveolentis 10-20 part, Germinatus Phragmitis 10-20 part, Folium Coicis 10-20 part, Radix Angelicae Dahuricae 10-20 part, Fructus Toosendan 10-20 part, Herba Lepidogrammitis rostratae 10-20 part.

2. a kind of Chinese medicine preparation for the treatment of cerebral infarction according to claim 1, is characterized in that, be made up of the raw material of following weight portion:

Flos Carthami 12-18 part, Radix Angelicae Sinensis 12-18 part, Radix Rehmanniae Preparata 12-18 part, Radix Salviae Miltiorrhizae 12-18 part, Cortex Moutan 12-18 part, Herba Ecliptae 12-18 part, Fructus Corni 12-18 part, Fructus Mori 12-18 part, Ramulus Cinnamomi 12-18 part, Flos Tagetis Erectae inflorescence 12-18 part, Scorpio 12-18 part, Flos Magnoliae 12-18 part, Radix Oenotherae erythrosepalae 12-18 part, Rhizoma Atractylodis 12-18 part, Radix Glycyrrhizae 12-18 part, Carapax Et Plastrum Testudinis 12-18 part, Poria 12-18 part, Fructus Momordicae charantiae 12-18 part, Rhizoma Dioscoreae 12-18 part, Bulbus Allii 12-18 part, Herba Apii graveolentis 12-18 part, Germinatus Phragmitis 12-18 part, Folium Coicis 12-18 part, Radix Angelicae Dahuricae 12-18 part, Fructus Toosendan 12-18 part, Herba Lepidogrammitis rostratae 12-18 part.

3. a kind of Chinese medicine preparation for the treatment of cerebral infarction according to claim 1, is characterized in that, be made up of the raw material of following weight portion:

15 parts, Flos Carthami, Radix Angelicae Sinensis 15 parts, Radix Rehmanniae Preparata 15 parts, Radix Salviae Miltiorrhizae 15 parts, Cortex Moutan 15 parts, Herba Ecliptae 15 parts, Fructus Corni 15 parts, 15 parts, Fructus Mori, Ramulus Cinnamomi 15 parts, Flos Tagetis Erectae inflorescence 15 parts, Scorpio 15 parts, Flos Magnoliae 15 parts, Radix Oenotherae erythrosepalae 15 parts, Rhizoma Atractylodis 15 parts, 15 parts, Radix Glycyrrhizae, Carapax Et Plastrum Testudinis 15 parts, 15 parts, Poria, 15 parts, Fructus Momordicae charantiae, Rhizoma Dioscoreae 15 parts, 15 parts, Bulbus Allii, Herba Apii graveolentis 15 parts, Germinatus Phragmitis 15 parts, Folium Coicis 15 parts, the Radix Angelicae Dahuricae 15 parts, Fructus Toosendan 15 parts, Herba Lepidogrammitis rostratae 15 parts.

4. a kind of Chinese medicine preparation for the treatment of cerebral infarction according to claim 1-3 any one, is characterized in that, soup potus preparation method of the present invention is specially:

5. a kind of Chinese medicine preparation for the treatment of cerebral infarction according to claim 1-3 any one, it is characterized in that, injection preparation of the present invention is specially:

6. a kind of Chinese medicine preparation for the treatment of cerebral infarction according to claim 1-3 any one, is characterized in that, preparation method process of the present invention is: