CN104524174A - Traditional Chinese medicine composition for treating rheumatic arthralgia and preparation method thereof - Google Patents

Traditional Chinese medicine composition for treating rheumatic arthralgia and preparation method thereof Download PDF

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CN104524174A
CN104524174A CN201510034659.3A CN201510034659A CN104524174A CN 104524174 A CN104524174 A CN 104524174A CN 201510034659 A CN201510034659 A CN 201510034659A CN 104524174 A CN104524174 A CN 104524174A
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radix
herba
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folium
chinese medicine
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杨睿
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Abstract

The invention provides a traditional Chinese medicine composition for treating rheumatic arthralgia. The composition accords with the principle of traditional Chinese medicine combination, firstly, delavay schefflera root, galium aparine, achnatherum inebrians, oriental buckthorn root, phlomis umbrosa, small-leaved desmodium root, radix araliae armatae, avicennia pricklyash root, sassafras tzumu, oriental grape root, hemiphragma heterophyllum, oriental bitteraweet leaf, oriental bittersweet root, nandina root and conespike flemingia root are taken as monarch and minister drugs fundamentally to clear heat, induce diuresis, relax muscles and tendons, remove obstruction from meridians, promot blood circulation and relieve pain, and are used for playing key roles in treating rheumatic arthralgia; ophiopogon latifolius, ginseng leaves, cherry leaves, phyllan lhus mat shilllirae, water spinach root, common exbucklandia stem, marsh equisetum, style pachysandra herb, eurya japonica, illicium verum, kamuning, pepper, suncured ginseng, longan pulp and mulberry are taken as assistant drugs to achieve coordinating effects of tranquilizing, calming, strengthening spleen and inducing diuresis, strengthening the treatment functions of monarch drugs and minister drugs in relaxing muscles, stimulating blood circulation, relieving pain, and restraining toxic and side effects of other drugs.

Description

A kind of Chinese medicine composition for the treatment of rheumatic arthralgia and preparation method thereof
Technical field
The present invention relates to medicine and pharmacology technical field, specifically a kind of Chinese medicine composition for the treatment of rheumatic arthralgia and preparation method thereof.
Background technology
Rheumatism, the traditional Chinese medical science also claims " arthromyodynia ", is the common intractable disease of a class, often with pain symptom.How effective alleviating pain is the rheumatismal difficult problem for the treatment of.The pain that doctor trained in Western medicine causes for rheumatism, belongs to the one of complex regional pain syndrome, forms chronic long-term local inflammation cause relevant cell factor to discharge the local response caused in part because of vasodilation, swelling and edema.
Chinese medicine thinks that rheumatism pathogenic factor and pathogenic process have four kinds substantially:
1, internal organs negative and positive internal injury: say by the viewpoint of traditional Chinese medical science yin-yang and five elements, the five internal organs are the heart, liver, spleen, lung, kidney.Heart governing blood and vessels: liver governing tendons; Spleen governing muscles; Lung governing skin and hair; Kidney governing bones.Rheumatism mainly liver spleen kidney generation internal injury occurs, and the kidney being the origin of congenital constitution.The raw marrow of store essential substances is bone at body is the viscus with functions of reproduction and development; Liver be muscle this, the raw muscle of store blood, system department muscles and bones joint; The spleen being the foundation of acquired constitution, the source of QI and blood biochemistry, main limb muscle.The Yinyang of human body must keep balance, if negative and positive are uneven, occurs that inclined Sheng declines partially, is subject to pathogen and invades, so there is rheumatismal heat and cold Symptoms.
2, the heresy of diseases caused by exogenous pathogenic factor six climate exopathogens: the pathogen of six climate exopathogens refers to that wind, cold, administration, wet, dry, that fire six kinds is normal gas six gas cuts too enter the person and cause the gas of morbidity to be just called pathogen, and rheumatism is subject to wind, cold, wet pathogen and invades personal and occur.Migratory BI-syndrome caused mainly by pathogenic wind; Cold survivor is arthralgia aggravated by cold; Dampness victor is damp arthralgia.Wind-cold damp pathogen impatency meridians and joint, stagnation of QI and blood may bring about pain, so cause joint swelling and pain.
3, raw in phlegm-turbidity and blood stasis blood: namely expectorant is turbid is the pathological product of human body under pathogenic factor effect with blood stasis, also human body can be acted on as the cause of disease, rheumatism has mostly chronicly carries out process, disease for a long time, then pathogenic factor going from the exterior into the interior, by gently weighing, causes visceral dysfunction, and the result of visceral dysfunction just produces the turbid and blood stasis of expectorant, these are exactly the touching and basic reason of refractory of the rheumatism state of an illness.
4, ying-qi defends blood imbalance: the traditional Chinese medical science says that ying-qi defends blood, and in ying-qi arteries and veins, defensive QI circulating outside the vessel, negative and positive are passed through mutually, and controlled atmosphere blood is smooth.Nutrition extremity bones of the body collectively zang-fu differentiation.Battalion defends and adjusts, and defends the body surface that gas protects people outside, and defence pathogen invades health, disharmony of nutrient QI with defensive QI, and pathogen is taken advantage of a weak point, and it is one of key factor of rheumatism morbidity that Gu Ying defends imbalance.
But arthralgia is the cardinal symptom performance of arthromyodynia, the method for the treatment of rheumatic arthralgia has treatment by Chinese herbs, western medicine, acupuncture and moxibustion therapy, electrotherapy etc. at present.Treatment by Chinese herbs is generally divided into oral medicine and medicine for external use two kinds, and clinical verification endo-medicine is expensive; And medicine for external use can only temporary relief pain, externally applied ointment easily causes the side effect such as eczema to skin.Western medicine usually adopts antibiotic, aspirin and hormone anti-inflammatory analgetic, prints active rheumatism, can be eased, take stopgap measures and do not effect a permanent cure in the short time, and toxic and side effects is comparatively large, cannot be effected a radical cure.Although acupuncture and moxibustion therapy, electrotherapy have no side effect, medical expense is expensive, and treatment time is longer, brings very large inconvenience to the economy of patient with life.
Summary of the invention
Technical problem to be solved by this invention is, provides that a kind of formula is simple, processing technology is easy, and the little and convenient drug administration of toxic and side effects, medicament is easy to manufacture, new drug with low cost.The present invention is Chinese medicine preparation, can reach wind-damp dispelling, supplementing QI for promoting the production of body fluid, Soothe tendons and activating-blood anodyne, spleen invigorating mind calming, heat clearing and damp drying, the object of strengthening bone and muscle.The present invention adopts the Chinese crude drug of different properties, has carried out scientific compatibility, can reach desirable therapeutic effect, and safety, toxic and side effects is little, and preparation is simple, and focus of going directly, healing time is short, not easily recurs after healing.
The invention provides a kind of Chinese medicine composition for the treatment of rheumatic arthralgia, medicine of the present invention meets the principle of drug matching, first fundamentally start with, with Radix Schefflerae Delavayi, Herba Galii Teneri, Herba oxytropis glabrae, Radix rhamni crenatae, Herba phlomidis, Radix desmodiik microphylli, Radix araliae armatae, Radix Zanthoxyli Avicennae, Radix sassafratis, Radix vitis flexuosae, Herba hemipharagmatis heterophylli, Folium Celastri Orbiculati, Radix Celastri Orbiculati, Radix Nandinae Domesticae, Herba Moghaniae fruticulosa is the medicine of the monarch and his subjects, clearing away heat-damp and promoting diuresis, channels sootheing and network vessel quickening, promoting blood circulation and stopping pain, treatment for rheumatic arthralgia part plays a crucial role, with Radix Ophiopogonis Dracaenoidis, Folium Ginseng, Folium Pruni pseudocerasi, Herba Phyllanthi matsumuraes, Radix ipomoeae aquaticae, Caulis Exbucklandiae Populneae, Herba Equiseti Palustris, Herba Pachysandrae Stylosae, Ramulus et Folium Euryae Japonicae, Fructus Anisi Stellati, Folium Et Cacumen Murrayae, Pericarpium Zanthoxyli, Radix Ginseng, Arillus Longan, the medicine of Fructus Mori for assisting a ruler in governing a country, calming heart and tranquilizing mind, invigorating spleen to remove dampness plays coordinative role, strengthen the relaxing muscles and tendons to promote blood circulation of monarch drug and ministerial drug, the function of pain relieving, and restrict the toxic and side effects of other drug.These material combination make each efficacy of drugs produce synergism, giving consideration to both the incidental and fundamental, and medication is gentle, thus effectively can treat rheumatic arthralgia, the present invention can reach desirable therapeutic effect, and safety, toxic and side effects is little, and preparation is simple, the through focus of energy, healing time is short, not easily recurs after healing.
For solving the problems of the technologies described above, the invention provides a kind of Chinese medicine composition for the treatment of rheumatic arthralgia, in described Chinese medicine composition, the ratio of weight and number of various crude drug is:
Radix Schefflerae Delavayi 30-40 part, Herba Galii Teneri 30-40 part, Herba oxytropis glabrae 30-40 part, Radix rhamni crenatae 30-40 part, Herba phlomidis 30-40 part, Radix desmodiik microphylli 30-40 part, Radix araliae armatae 30-40 part, Radix Zanthoxyli Avicennae 30-40 part, Radix sassafratis 30-40 part, Radix vitis flexuosae 30-40 part, Herba hemipharagmatis heterophylli 30-40 part, Folium Celastri Orbiculati 30-40 part, Radix Celastri Orbiculati 30-40 part, Radix Nandinae Domesticae 30-40 part, Herba Moghaniae fruticulosa 30-40 part, Radix Ophiopogonis Dracaenoidis 20-30 part, Folium Ginseng 20-30 part, Folium Pruni pseudocerasi 20-30 part, Herba Phyllanthi matsumuraes 20-30 part, Radix ipomoeae aquaticae 20-30 part, Caulis Exbucklandiae Populneae 20-30 part, Herba Equiseti Palustris 20-30 part, Herba Pachysandrae Stylosae 20-30 part, Ramulus et Folium Euryae Japonicae 20-30 part, Fructus Anisi Stellati 20-30 part, Folium Et Cacumen Murrayae 20-30 part, Pericarpium Zanthoxyli 20-30 part, Radix Ginseng 20-30 part, Arillus Longan 20-30 part, Fructus Mori 20-30 part.
Described a kind of Chinese medicine composition for the treatment of rheumatic arthralgia, the ratio of weight and number of various crude drug also can be:
Radix Schefflerae Delavayi 32-38 part, Herba Galii Teneri 32-38 part, Herba oxytropis glabrae 32-38 part, Radix rhamni crenatae 32-38 part, Herba phlomidis 32-38 part, Radix desmodiik microphylli 32-38 part, Radix araliae armatae 32-38 part, Radix Zanthoxyli Avicennae 32-38 part, Radix sassafratis 32-38 part, Radix vitis flexuosae 32-38 part, Herba hemipharagmatis heterophylli 32-38 part, Folium Celastri Orbiculati 32-38 part, Radix Celastri Orbiculati 32-38 part, Radix Nandinae Domesticae 32-38 part, Herba Moghaniae fruticulosa 32-38 part, Radix Ophiopogonis Dracaenoidis 22-28 part, Folium Ginseng 22-28 part, Folium Pruni pseudocerasi 22-28 part, Herba Phyllanthi matsumuraes 22-28 part, Radix ipomoeae aquaticae 22-28 part, Caulis Exbucklandiae Populneae 22-28 part, Herba Equiseti Palustris 22-28 part, Herba Pachysandrae Stylosae 22-28 part, Ramulus et Folium Euryae Japonicae 22-28 part, Fructus Anisi Stellati 22-28 part, Folium Et Cacumen Murrayae 22-28 part, Pericarpium Zanthoxyli 22-28 part, Radix Ginseng 22-28 part, Arillus Longan 22-28 part, Fructus Mori 22-28 part.
Described a kind of Chinese medicine composition for the treatment of rheumatic arthralgia, the ratio of weight and number of various crude drug can also be:
Radix Schefflerae Delavayi 35 parts, Herba Galii Teneri 35 parts, Herba oxytropis glabrae 35 parts, Radix rhamni crenatae 35 parts, Herba phlomidis 35 parts, Radix desmodiik microphylli 35 parts, Radix araliae armatae 35 parts, Radix Zanthoxyli Avicennae 35 parts, Radix sassafratis 35 parts, Radix vitis flexuosae 35 parts, Herba hemipharagmatis heterophylli 35 parts, Folium Celastri Orbiculati 35 parts, Radix Celastri Orbiculati 35 parts, Radix Nandinae Domesticae 35 parts, Herba Moghaniae fruticulosa 35 parts, Radix Ophiopogonis Dracaenoidis 25 parts, Folium Ginseng 25 parts, Folium Pruni pseudocerasi 25 parts, Herba Phyllanthi matsumuraes 25 parts, Radix ipomoeae aquaticae 25 parts, Caulis Exbucklandiae Populneae 25 parts, Herba Equiseti Palustris 25 parts, Herba Pachysandrae Stylosae 25 parts, Ramulus et Folium Euryae Japonicae 25 parts, Fructus Anisi Stellati 25 parts, Folium Et Cacumen Murrayae 25 parts, 25 parts, Pericarpium Zanthoxyli, Radix Ginseng 25 parts, Arillus Longan 25 parts, 25 parts, Fructus Mori.
For solving the problems of the technologies described above, the present invention also provides a kind of preparation method for the treatment of the Chinese medicine composition of rheumatic arthralgia, and the form of Chinese drug of described Chinese medicine composition is that sweet preparation method of refining pill comprises:
A, get crude drug and put into soak with ethanol, heat is extracted 1 time, and becoming extractum shape, is component 1;
B, medicinal residues extracting in water 2 times, thickening filtration is extractum shape, is component 2;
C, above-mentioned two kinds of extractum are condensed into pasty state, add Mel and be twisted into pill.
In described step a, can get the 60-90% soak with ethanol 1-2 hour that crude drug adds 5-10 times amount, heating extraction 1-2 hour, removes supernatant, and mass continues heating and is concentrated into extractum shape, stand for standby use, becomes component 1.
In described step b, medicinal residues can be soaked 1-2 hour, extract twice, each 1-1.5 hour, merge extractive liquid, 80-120 order filters, then is the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.36 extractum, heating is concentrated, 30 minutes ~ 45 minutes, extracts active ingredient, concentrated solution is settled into extractum shape, as component 2.
For solving the problems of the technologies described above, the present invention also provides a kind of preparation method for the treatment of the Chinese medicine composition of rheumatic arthralgia, and the form of Chinese drug of described Chinese medicine composition is that the preparation method of capsule comprises:
A, Fructus Anisi Stellati and Pericarpium Zanthoxyli are put into ethanol heating and refluxing extraction;
B, get surplus stock in above-mentioned side again, add water heating and refluxing extraction;
C, above-mentioned two kinds of extracting solution to be merged, decompression recycling ethanol concentrated sucking filtration absorption, obtain crude drug; Canned.
In described step a, Fructus Anisi Stellati and Pericarpium Zanthoxyli can be put into 10 times amount ethanol, heating and refluxing extraction 2 times, each 1 ~ 2 hour, extract active ingredient, 2 extracting solution be merged and leaves standstill; In described step b, by surplus stock 10 times of water gagings, 3 extracting solution each 45 minutes ~ 1 hour, are merged and leave standstill by heating and refluxing extraction 3 times.
In described step c, can by the merging of above-mentioned two kinds of filtrates, decompression recycling ethanol to be concentrated into liquor strength be 0.4g crude drug/mL, after sucking filtration, when the relative density of filtrate is about 20 DEG C 1.06; Above-mentioned filtrate is the macroporous adsorptive resins of 10L through volume, first uses deionized water or the distilled water eluting of 10 times of resin column volumes, then uses 95% ethanol elution of 5 times of resin column volumes, collects ethanol elution, removes solvent, obtains raw material medicated powder, incapsulate.
For solving the problems of the technologies described above, the present invention also provides a kind of preparation method for the treatment of the Chinese medicine composition of rheumatic arthralgia, and the form of Chinese drug of described Chinese medicine composition is that the preparation method of medicated wine agent comprises:
Each crude drug is taken according to weight proportion described in formula, be ground into coarser powder after being dried by ready Chinese herbal medicine, bind up with gauze the container being placed in sealing, add in the Chinese liquor of 10 times amount and leave standstill immersion 50 days, after medicinal material coarse powder is fully expanded, waste, leach clear liquid medicine and namely obtain medicated wine finished product.
For solving the problems of the technologies described above, the present invention also provides a kind of dosage form for the treatment of the Chinese medicine composition of rheumatic arthralgia, and pharmaceutical dosage form can be: sugar coated tablet, film coated tablet, enteric coated tablet, capsule, oral liquid, suck agent, granule, electuary, honey pill agent, powder, sublimed preparation, solution, suppository, plaster, syrup, powder.
beneficial effect of the present invention:
The present invention is Chinese medicine preparation, can reach wind-damp dispelling, supplementing QI for promoting the production of body fluid, Soothe tendons and activating-blood anodyne, spleen invigorating mind calming, heat clearing and damp drying, the object of strengthening bone and muscle.Processing technology of the present invention is easy, and convenient drug administration, medicament is easy to manufacture, with low cost.The present invention adopts the Chinese crude drug of different properties, has carried out scientific compatibility, can reach desirable therapeutic effect, and safety, toxic and side effects is little, and focus of going directly, healing time is short, not easily recurs after healing.
detailed description of the invention:
Chinese medicine is thought, after human body flesh table meridians are subjected to wind, cold, wet, evil invasion and attack, cause muscles and bones joint aches, numbness, weigh, the disease such as the unfavorable or arthroncus of body, wherein the most obvious Symptoms is the pain in joint, wind and cold wets that three gas are harmonious from negative and positive in human body and to show as different numbness sick, as in body, YIN-cold wins partially, then pathogen cold being transformed from excessive YIN and show as arthralgia due to cold, arthralgia chiefly caused by damp pathogen.The sick effect in generation, evolution of numbness, thinking that the positive deficiency of vital energy is endogenous cause of ill, is the pathogenetic prerequisite of numbness, positive QI-insufficiency, the heresy that wind and cold is damp and hot is invaded in an opponent's defence and is caused a disease, if healthy energy virtual loss, enemy intrusion or invasion's internal organs, then internal organs arthromyodynia is there's no one who doesn't or isn't by giving birth to, " prolonged illness people network, for a long time pain stay the stasis of blood ", the venation in stagnation of blood stasis joint, QI-blood circulation is not smooth, therefore stagnation of QI and blood may bring about pain; The damp and hot heresy of wind and cold is not only the result of rheumatic arthralgia recurrent exerbation, especially its protracted inflammation, the difficult important step healed of refractory.Therefore wind and cold is damp and hot, stagnation of liver-QI with deficiency of the spleen blood stasis is the main pathology link that Bi condition occurs and recurs, clearing away heat-damp and promoting diuresis, promoting blood circulation to remove obstruction in the collateral, soothing liver and strengthening spleen, calming heart and tranquilizing mind method are its base therapy rule for the treatment of.
Treatment is first fundamentally started with, with Radix Schefflerae Delavayi, Herba Galii Teneri, Herba oxytropis glabrae, Radix rhamni crenatae, Herba phlomidis, Radix desmodiik microphylli, Radix araliae armatae, Radix Zanthoxyli Avicennae, Radix sassafratis, Radix vitis flexuosae, Herba hemipharagmatis heterophylli, Folium Celastri Orbiculati, Radix Celastri Orbiculati, Radix Nandinae Domesticae, Herba Moghaniae fruticulosa is the medicine of the monarch and his subjects, clearing away heat-damp and promoting diuresis, channels sootheing and network vessel quickening, promoting blood circulation and stopping pain, treatment for rheumatic arthralgia part plays a crucial role, with Radix Ophiopogonis Dracaenoidis, Folium Ginseng, Folium Pruni pseudocerasi, Herba Phyllanthi matsumuraes, Radix ipomoeae aquaticae, Caulis Exbucklandiae Populneae, Herba Equiseti Palustris, Herba Pachysandrae Stylosae, Ramulus et Folium Euryae Japonicae, Fructus Anisi Stellati, Folium Et Cacumen Murrayae, Pericarpium Zanthoxyli, Radix Ginseng, Arillus Longan, the medicine of Fructus Mori for assisting a ruler in governing a country, calming heart and tranquilizing mind, invigorating spleen to remove dampness plays coordinative role, strengthen the relaxing muscles and tendons to promote blood circulation of monarch drug and ministerial drug, the function of pain relieving, and restrict the toxic and side effects of other drug.These material combination make each efficacy of drugs produce synergism, giving consideration to both the incidental and fundamental, and medication is gentle, thus effectively can treat rheumatic arthralgia, the present invention can reach desirable therapeutic effect, and safety, toxic and side effects is little, and preparation is simple, the through focus of energy, healing time is short, not easily recurs after healing.
the property of medicine and the pharmacology of medicine selected by the present invention are respectively:
Radix Schefflerae Delavayi:
[nature and flavor] mildly bitter flavor; Puckery; Property is put down
[function cures mainly] dispelling, collateral-activating; Strengthening the tendons and bones; Promoting flow of QI and blood.Main air pain of dampness syndrome; Soreness of waist and knee joint; Treating swelling and pain by traumatic injury; Breast side of body abdominal distention.
1. " Guizhou folk medicine ": " logical stool, detumescence poison.”
2. " the practical Chinese herbal medicine in Guangxi newly selects ": " dispelling, collateral-activating.Control fracture, dampen, rheumatic arthritis, lumbar muscle strain.”
Herba Galii Teneri:
[meridian distribution of property and flavor] toil, cold.
[function cures mainly] cures mainly swollen ulcer drug; Mastitis; Appendicitis; Edema; Cold, fever; Dysentery; Urinary tract infection; Hematuria; Gingival hemorrhage; Knife injury is hemorrhage.
1. " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " control damp and hot, all through exopathogenic heat, chronic consumptive disease, virgin consumptive disease, bones and muscles pain, pyretic stranguria, red white turbid urine, beautiful pain in the penis.Move back blood system dysphoria with smothery sensation, only hematuria.”
2. " Guizhou side's medicine among the people collection ": " control scabies.”
3. " Guangxi Chinese medicinal herbal ": " control married woman's dysmenorrhea.Mash again extracting juice and rush sticky rice syrup, control and fly upward skin ulcer.”
4. Jiangxi " medical herbs handbook ": " heat-clearing and toxic substances removing, reducing swelling and alleviating pain.Control carbuncle, appendicitis, closely for for cancer.”
5. " Kunming conventional medical herbs among the people ": " dissipating blood stasis blood, controls phlegm-fire heat symptom-complex, and acute conjunctivitis mist gum is many, rheumatic bone-setting pain for heat clearing and inflammation relieving, wind-damp dispelling.”
6. " Yunnan Chinese herbal medicine ": " clearing away heat and cooling blood, diuresis.Control stranguria with blood, urinary tract infection.”
Herba oxytropis glabrae:
[function cures mainly ]anesthesia calm pain relieving.Control arthralgia toothache neurasthenia skin pruritus.
Radix rhamni crenatae:
[nature and flavor] are bitter, flat, poisonous.
[return through] " east, Fujian book on Chinese herbal medicine ": enter Liver Channel.
[function cures mainly ]have clearing away heat-damp and promoting diuresis, parasite killing, removing toxic substances, controls scabies, tinea, leprosy, furuncle, leprosy, effect of ascariasis.
Herba phlomidis:
[nature and flavor]: pungent, puckery, temperature, flat.
[function cures mainly]: dispelling, collateral-activating, bone and muscle strengthening, detumescence.For flu, chronic bronchitis, rheumatic arthritis, lumbago, traumatic injury, furuncle toxic swelling.
Radix desmodiik microphylli:
[nature and flavor] Jiangxi " medical herbs handbook ": sweet, flat.
[function cures mainly-Radix desmodiik microphylli effect] clearing away heat-damp and promoting diuresis, hemostasis, dredging collateral.To harness the Yellow River subcutaneous ulcer, dysentery, urine leaching pain, rheumatalgia, spitting of blood, metrorrhagia, leucorrhea, hemorrhoid, traumatic injury.
1. " Yunnan Chinese herbal medicine ": anti-inflammation hemostasia, dampness removing dredging collateral.Control puerperal hemorrhage, redly collapse leucorrhea, amenorrhea, weak night sweat, dysentery, rheumatism, urinary tract infection, hemorrhoid, proctoptosis, traumatic injury.
2. Jiangxi " medical herbs handbook ": clearing away heat to improve acuity of vision.
Radix araliae armatae:
For the root of Araliaceae Hu Ci Cortex araliae chinensis, root bark or branch and leaf.Under being born in hillside sparse woods and small stream enters, the sun-drenched place of thick grass.Root can be adopted the whole year, and branch and leaf summer, autumn gather.
[nature and flavor]acrid in the mouth, warm in nature, nontoxic.
[function] dissipating blood stasis for subsidence of swelling, expelling wind and removing dampness.
Control traumatic injury, rheumatic arthralgia, stomachache, diarrhoea, dysentery, leucorrhea, carbuncle, furuncle swells.
1. " Guangxi Chinese herbal medicine ": dissipating blood stasis for subsidence of swelling, wind-damp dispelling.
Control traumatic injury, rheumatalgia.
2. " the practical Chinese herbal medicine in Guangxi newly selects ": dissipating blood stasis for subsidence of swelling, antibacterial pain relieving.
Control traumatic injury, carbuncle, furuncle, hepatitis, nephritis, prostatitis, acute arthritis, stomachache, diarrhoea, dysentery, leucorrhea.
Radix Zanthoxyli Avicennae:
[nature and flavor] are pungent, temperature
[function cures mainly] dispels the wind, removing dampness, detumescence, dredging collateral.Control laryngopharynx swelling and pain, general edema with yellowish skin, malaria, rheumatic ostalgia, traumatic injury is dampened.
Radix sassafratis:
[nature and flavor] are pungent; Sweet; Temperature [return through] liver; Spleen channel [function cures mainly] expelling wind and removing dampness; Promoting blood circulation to remove blood stasis; Hemostasis.Main air pain of dampness syndrome; Traumatic injury; Lumbar muscle strain; Hemiplegia; Traumatic hemorrhage.
Radix vitis flexuosae:
Radix vitis flexuosae is the root of vitaceae Pueraria lobota Bud, cures mainly the symptom such as body void, joint aches, traumatic injury after being ill.
Jiangxi " Chinese herbology ": " sweet, flat."
1. " not Lu ": " main slow muscle, order is not bitterly."
2. Jiangxi " Chinese herbology ": " nourishing qi and blood, reuniting the fractured tendons and bones, longue meat."
Herba hemipharagmatis heterophylli:
The herb that [subject source] is goatweed diversifolious hemiphragma herb or root.
[nature and flavor] taste is micro-sweet; Light; Warm in nature.1. " Zhiwu Mingshi Tukao ": " warm in nature, taste is micro-sweet." 2. " Guizhou medical herbs ": " property is put down, and taste is micro-sweet." 3. " Chinese herbal medicine is commonly used in Tibet ": " warm in nature, lightly seasoned.”
[return through] GUIXIN; Liver Channel.
[function with cure mainly] promoting blood flow to regulate menstruation, relaxing muscles and tendons and activating QI and blood in the collateral, expelling wind and removing dampness.For amenorrhea, menoxenia, pulmonary tuberculosis, tonsillitis, traumatic injury, lumbago due to pathogenic wind-dampness; QI invigorating pain relieving, blood stasis removing stops blooding, and control cough and spit blood, neurasthenia, amenorrhea is suffered from abdominal pain; Eczema is controlled in external, skin infection, stomatitis, scrofula, and skin ulcer swells noxious dampness, tetanus.
Folium Celastri Orbiculati:
[nature and flavor] are bitter; Pungent; Flat
[return through] Liver Channel
[function cures mainly] expelling wind and removing dampness; Removing toxic substances and promoting subsidence of swelling; Promoting blood circulation and stopping pain.Main air pain of dampness syndrome; Skin infection furuncle and phyma; Herpes; Eczema; Traumatic injury; Snake bite and insect sting.
Radix Celastri Orbiculati:
[nature and flavor] are pungent; Bitter; Flat
[return through] kidney; Bladder; Liver Channel
[function cures mainly] expelling wind and removing dampness; Promoting blood circulation to restore menstrual flow; Subduing swelling and detoxicating.Main air pain of dampness syndrome; Treating swelling and pain by traumatic injury; Amenorrhea; Headache; Lumbago; Colicky; Dysentery; Discharging fresh blood stool; Swollen ulcer drug; Burn due to hot liquid or fire; Venom.
Radix Nandinae Domesticae:
[nature and flavor] are bitter, cold.
1. " Chongqing medical herbs ": " bitter in the mouth, cold in nature, nontoxic."
2. " Fujian Chinese herbal medicine ": " bitter, flat."
Function cures mainly: dispel the wind, heat clearing away, and dehumidifying, reduces phlegm.Control headache due to pathogenic wind-heat, cough due to lung-heat, jaundice due to damp-heat, rheumatic arthralgia, acute catarrhal conjunctivitis, skin infection, scrofula.
Herba Moghaniae fruticulosa:
[nature and flavor] micro-hardship is sweet, cool.Return through lung; Spleen channel
[function cures mainly] brings down a fever dehumidifying, and disappear infantile malnutrition, cough-relieving.Control hyperpyrexia, flu, rheumatic arthritis, dysmenorrhea, infantile malnutrition, diarrhoea, dyspepsia.
Radix Ophiopogonis Dracaenoidis:
[nature and flavor] property is put down, sweet in the mouth.
[function cures mainly] centering is calmed the nerves, and relieving cough and resolving phlegm, controls cardiopalmus, rheumatic heart disease, pulmonary tuberculosis, chronic tracheitis, bronchitis.
Folium Ginseng:
[meridian distribution of property and flavor] is bitter, sweet, cold.Attach to the lung and stomach meridians.
[function cures mainly] QI invigorating, lung benefiting, drives away summer heat, and promotes the production of body fluid.For qi-asthenia cough, summer-heat is irritated, and Tianjin wound is thirsty, and the head is unclear, and extremity are tired weary.
Folium Pruni pseudocerasi:
nature and flavor sweetness and bitterness temperature
gui Jing book on Chinese herbal medicine is new again enter liver spleen two warp
function cures mainly-effect of Folium Pruni pseudocerasi stomach warming spleen invigorating hemostasis removing toxic substances control cold syndrome of the stomach food stagnation diarrhoea spit blood sore
Herba Phyllanthi matsumuraes:
With all herbal medicine; Feeble QI is bitter in the mouth, puckery.1. revive doctor's " Chinese herbal medicine handbook ": heat clearing away, improving eyesight, stomach invigorating, dysentery relieving, eliminating dampness by diuresis, diuresis.
Radix ipomoeae aquaticae: weng
[return through] kidney; Lung; Spleen channel
[function cures mainly] invigorating spleen to remove dampness.Housewife female leucorrhea; Empty pouring.
Caulis Exbucklandiae Populneae:
[nature and flavor] are sour and astringent, temperature, mild toxicity.
[function cures mainly-Caulis Exbucklandiae Populneae effect] relaxing muscles and tendons to promote blood circulation, activating collaterals to relieve pain.Treating rheumatic arthritis, sciatica.
Herba Equiseti Palustris:
[nature and flavor] " east, Fujian book on Chinese herbal medicine ": property is put down, sweet and slightly bitter taste.
[return through] " east, Fujian book on Chinese herbal medicine ": enter liver, lung, gallbladder three warp.
[function cures mainly-Herba Equiseti Palustris effect] dispelling wind, improving eyesight, invigorates blood circulation, relaxing muscles and tendons.
Herba Pachysandrae Stylosae:
[nature and flavor] toil, temperature, poisonous." Guizhou medical herbs "; " pungent, temperature."
[function cures mainly] wind-damp dispelling, invigorates blood circulation, pain relieving.Dispelling the wind and dampness pathogens arthralgia pain, impairment caused by overstrain lumbago, traumatic injury.
" Guizhou medical herbs ": " invigorate blood circulation, blood stasis dispelling, pain relieving."
Ramulus et Folium Euryae Japonicae:
[meridian distribution of property and flavor] is bitter, puckery, flat.
[function cures mainly] expelling wind and removing dampness, detumescence, hemostasis.For rheumatic arthritis, ascites, traumatic hemorrhage.
Fructus Anisi Stellati:
[meridian distribution of property and flavor] pungent, warm, return liver,kidney,spleen stomach warp;
[function cures mainly] warming YANG to expel cold, regulating QI to relieve pain.For colic of cold type stomachache, lumbago due to renal deficiency, gastrofrigid vomiting, coldness and pain in the epigastrium.
Folium Et Cacumen Murrayae:
[meridian distribution of property and flavor] is pungent, micro-hardship, temperature, slightly poisonous, returns liver, stomach warp;
[function cures mainly] promoting the circulation of QI to relieve pain, promoting blood circulation to remove blood stasis, for stomachache, rheumatic arthralgia, external treatment is had a toothache, tumbling and swelling, worm venom.
Pericarpium Zanthoxyli:
[meridian distribution of property and flavor] acrid in the mouth, warm in nature.Slightly poisonous.Return spleen, stomach, kidney channel.
[effect] has the function of warming middle-JIAO to relieve pain, killing parasites for relieving itching.Pericarpium Zanthoxyli is slightly poisonous, and pungent using warming therapy is very strong, and the effect of external killing parasites for relieving itching is good.For scabies, eczema or skin pruritus.Take pepper water and can remove parasite; There is effect of fragrant stomach invigorating, warming spleen and stomach for dispelling cold, removing damp and stopping pain, parasite killing removing toxic substances, antipruritic solution raw meat.
[pharmacology] bacteriostatic test: Pericarpium Zanthoxyli is to anthrax bacillus, Hemolytic streptococcus, diphtheria corynebacterium, Diplococcus pneumoniae, staphylococcus aureus, lemon yellow and 10 kinds of gram positive bacterias such as Staphylococcus albus, bacillus subtilis, and the enteral pathogenic bacterium such as escherichia coli, Song Nei Shi dysentery bar flute, Bacillus proteus, typhoid fever and Salmonella paratyphi, bacillus pyocyaneus, vibrio cholera all have obvious inhibitory action.The water logging agent of 1:4 also has inhibitory action to star nocardia.According to animal experiment, a small amount of clothes that continue can promote relevant metabolic glandular development, and volume then can promote the glandular development about reproduction.This just demonstrates the understanding of ancients' " temperature male wind-supplying kidney ".
Radix Ginseng:
[meridian distribution of property and flavor] sweet in the mouth, micro-hardship, slightly warm in nature; Gui Jing: return lung, spleen channel.
[effect] strongly invigorating primordial QI, mends strengthening spleen and lung, promoting the production of body fluid to quench thirst, the mind calming and mentality promoting.
Arillus Longan:
[nature and flavor] are warm in nature, and taste is sweet.
[function cures mainly] invigorating the heart and spleen, nourishing blood to tranquillize the mind.For insufficiency of vital energy and blood, severe palpitation, forgetful insomnia, blood deficiency and yellow complexion.
Fructus Mori:
[nature and flavor] are sweet, are slightly cold; GUIXIN, liver, kidney channel.
[function cures mainly] controls hepatic and renal YIN deficiency, sends and takes off, constipation, and order is dark, tinnitus, former infections, articular instability.It is improved skin (comprising scalp) blood supply, nutrition skin, makes the effects such as the delicate and black hair of skin, and can slow down aging.Fructus Mori is that middle-aged and elderly people is healthy and strong U.S. face, antidotal good fruit and good medicine.Normal food Fructus Mori can improving eyesight, the symptom that relieving eye strain is dry and astringent.Fructus Mori has immunologic enhancement.Fructus Mori has effect of gain to spleen, has potentiation to hemolytic reaction, can prevent human body artery sclerosis, skeletal joint sclerosis, enhance metabolism; Fructus Mori can promote the growth of erythrocyte, prevents leukopenia, and has auxiliary curative effect to diseases such as treatment diabetes, anemia, hypertension, hyperlipidemia, coronary heart disease, neurasthenias.Fructus Mori has the effects such as promoting the production of body fluid to quench thirst, facilitating digestion, help defecation, and proper amount of edible can promote gastric secretion, stimulates enterokinesia and removes scorching.The traditional Chinese medical science is thought, Fructus Mori is sweet in flavor and cold in property, there is the liver and the kidney tonifying, intestine moistening of promoting the production of body fluid, the effect such as black hair improving eyesight.
embodiment 1, formula:radix Schefflerae Delavayi 30g, Herba Galii Teneri 30g, Herba oxytropis glabrae 30g, Radix rhamni crenatae 30g, Herba phlomidis 30g, Radix desmodiik microphylli 30g, Radix araliae armatae 30g, Radix Zanthoxyli Avicennae 30g, Radix sassafratis 30g, Radix vitis flexuosae 30g, Herba hemipharagmatis heterophylli 30g, Folium Celastri Orbiculati 30g, Radix Celastri Orbiculati 30g, Radix Nandinae Domesticae 30g, Herba Moghaniae fruticulosa 30g, Radix Ophiopogonis Dracaenoidis 20g, Folium Ginseng 20g, Folium Pruni pseudocerasi 20g, Herba Phyllanthi matsumuraes 20g, Radix ipomoeae aquaticae 20g, Caulis Exbucklandiae Populneae 20g, Herba Equiseti Palustris 20g, Herba Pachysandrae Stylosae 20g, Ramulus et Folium Euryae Japonicae 20g, Fructus Anisi Stellati 20g, Folium Et Cacumen Murrayae 20g, Pericarpium Zanthoxyli 20g, Radix Ginseng 20g, Arillus Longan 20g, Fructus Mori 20g,
The present embodiment Chinese medicine composition is capsule, and its preparation method comprises:
By Fructus Anisi Stellati 20g, Pericarpium Zanthoxyli 20g, put into 10 times amount ethanol, heating and refluxing extraction 2 times, each 1 ~ 2 hour, extract active ingredient, 2 extracting solution are merged and leaves standstill, by Radix Schefflerae Delavayi 30g, Herba Galii Teneri 30g, Herba oxytropis glabrae 30g, Radix rhamni crenatae 30g, Herba phlomidis 30g, Radix desmodiik microphylli 30g, Radix araliae armatae 30g, Radix Zanthoxyli Avicennae 30g, Radix sassafratis 30g, Radix vitis flexuosae 30g, Herba hemipharagmatis heterophylli 30g, Folium Celastri Orbiculati 30g, Radix Celastri Orbiculati 30g, Radix Nandinae Domesticae 30g, Herba Moghaniae fruticulosa 30g, Radix Ophiopogonis Dracaenoidis 20g, Folium Ginseng 20g, Folium Pruni pseudocerasi 20g, Herba Phyllanthi matsumuraes 20g, Radix ipomoeae aquaticae 20g, Caulis Exbucklandiae Populneae 20g, Herba Equiseti Palustris 20g, Herba Pachysandrae Stylosae 20g, Ramulus et Folium Euryae Japonicae 20g, Folium Et Cacumen Murrayae 20g, Radix Ginseng 20g, Arillus Longan 20g, Fructus Mori 20g adds in 10 times of water gagings, heating and refluxing extraction 3 times, each 45 minutes ~ 1 hour, 3 extracting solution are merged and leaves standstill, by the merging of above-mentioned two kinds of filtrates, decompression recycling ethanol to be concentrated into liquor strength be 0.4g crude drug/mL, after sucking filtration, when the relative density of filtrate is about 20 DEG C 1.06, above-mentioned filtrate is the macroporous adsorptive resins of 10L through volume, first uses deionized water or the distilled water eluting of 10 times of resin column volumes, then uses 95% ethanol elution of 5 times of resin column volumes, collects ethanol elution, removes solvent, obtains raw material medicated powder, incapsulate.
Treatment model case: Zhang female 48 years old.Suffer from rheumatoid arthritis 8 years, extremities joint swells and ache, and refers to that toe is out of shape, restriction of neck motion, very painful.Through city's examination in hospital, erythrocyte sedimentation rate 80mm/h, rheumatoid factor positive (+), Long-term Hormone, medicine such as analgesia sheet etc., walking function obstacle, amyotrophy, agonizing, take the present embodiment capsule and treat two months, patient symptom obviously alleviates, and treats two months again, and erythrocyte sedimentation rate, rheumatoid factor recover normal, general joint pain takes a turn for the better, waist can straighten up, and patients clinical is cured, and follows up a case by regular visits to and has no multiple method in 2 years.
embodiment 2, formula:radix Schefflerae Delavayi 32g, Herba Galii Teneri 32g, Herba oxytropis glabrae 32g, Radix rhamni crenatae 32g, Herba phlomidis 32g, Radix desmodiik microphylli 32g, Radix araliae armatae 32g, Radix Zanthoxyli Avicennae 32g, Radix sassafratis 32g, Radix vitis flexuosae 32g, Herba hemipharagmatis heterophylli 32g, Folium Celastri Orbiculati 32g, Radix Celastri Orbiculati 32g, Radix Nandinae Domesticae 32g, Herba Moghaniae fruticulosa 32g, Radix Ophiopogonis Dracaenoidis 22g, Folium Ginseng 22g, Folium Pruni pseudocerasi 22g, Herba Phyllanthi matsumuraes 22g, Radix ipomoeae aquaticae 22g, Caulis Exbucklandiae Populneae 22g, Herba Equiseti Palustris 22g, Herba Pachysandrae Stylosae 22g, Ramulus et Folium Euryae Japonicae 22g, Fructus Anisi Stellati 22g, Folium Et Cacumen Murrayae 22g, Pericarpium Zanthoxyli 22g, Radix Ginseng 22g, Arillus Longan 22g, Fructus Mori 22g,
The form of Chinese drug of the present embodiment Chinese medicine composition is honey refining pill, and its preparation method comprises:
Get crude drug Radix Schefflerae Delavayi 32g, Herba Galii Teneri 32g, Herba oxytropis glabrae 32g, Radix rhamni crenatae 32g, Herba phlomidis 32g, Radix desmodiik microphylli 32g, Radix araliae armatae 32g, Radix Zanthoxyli Avicennae 32g, Radix sassafratis 32g, Radix vitis flexuosae 32g, Herba hemipharagmatis heterophylli 32g, Folium Celastri Orbiculati 32g, Radix Celastri Orbiculati 32g, Radix Nandinae Domesticae 32g, Herba Moghaniae fruticulosa 32g, Radix Ophiopogonis Dracaenoidis 22g, Folium Ginseng 22g, Folium Pruni pseudocerasi 22g, Herba Phyllanthi matsumuraes 22g, Radix ipomoeae aquaticae 22g, Caulis Exbucklandiae Populneae 22g, Herba Equiseti Palustris 22g, Herba Pachysandrae Stylosae 22g, Ramulus et Folium Euryae Japonicae 22g, Fructus Anisi Stellati 22g, Folium Et Cacumen Murrayae 22g, Pericarpium Zanthoxyli 22g, Radix Ginseng 22g, Arillus Longan 22g, Fructus Mori 22g adds the 60-90% soak with ethanol 1-2 hour of 5-10 times amount, heating extraction 1-2 hour, remove supernatant, mass continues heating and is concentrated into extractum shape, stand for standby use, become component 1, 1-2 hour soaked by medicinal residues, extract twice, each 1-1.5 hour, merge extractive liquid, 80-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.36 extractum, heating is concentrated, 30 minutes ~ 45 minutes, extract active ingredient, concentrated solution is settled into extractum shape, as component 2, above-mentioned two kinds of extractum are condensed into pasty state, add Mel and be twisted into pill.
Treatment model case: remaining certain, 35 years old, when examining, readme waist shoulder and left lower limb pain numbness were sent out cool more than 6 years, and especially to have bone joint, coxarthropathy very, it is acute to meet cold rnning, and when morning rises, pain increases the weight of, and limb activity is dumb, and activity alleviates gradually.Chemical examination: erythrocyte sedimentation rate 40mm/h, anti-" 0 " 900 unit, x-ray display is without sclerotin change, and feeling of numbness alleviates, take the present embodiment Chinese medicine honey refining pill, symptom disappears completely after two months, and joint motion freely, erythrocyte sedimentation rate 16mm/h, anti-" 0 " 420 unit, follows up a case by regular visits to and does not recur so far.
embodiment 3, formula:radix Schefflerae Delavayi 35g, Herba Galii Teneri 35g, Herba oxytropis glabrae 35g, Radix rhamni crenatae 35g, Herba phlomidis 35g, Radix desmodiik microphylli 35g, Radix araliae armatae 35g, Radix Zanthoxyli Avicennae 35g, Radix sassafratis 35g, Radix vitis flexuosae 35g, Herba hemipharagmatis heterophylli 35g, Folium Celastri Orbiculati 35g, Radix Celastri Orbiculati 35g, Radix Nandinae Domesticae 35g, Herba Moghaniae fruticulosa 35g, Radix Ophiopogonis Dracaenoidis 25g, Folium Ginseng 25g, Folium Pruni pseudocerasi 25g, Herba Phyllanthi matsumuraes 25g, Radix ipomoeae aquaticae 25g, Caulis Exbucklandiae Populneae 25g, Herba Equiseti Palustris 25g, Herba Pachysandrae Stylosae 25g, Ramulus et Folium Euryae Japonicae 25g, Fructus Anisi Stellati 25g, Folium Et Cacumen Murrayae 25g, Pericarpium Zanthoxyli 25g, Radix Ginseng 25g, Arillus Longan 25g, Fructus Mori 25g,
The form of Chinese drug of the present embodiment Chinese medicine composition is medicated wine agent, and its preparation method comprises:
Radix Schefflerae Delavayi 35g is taken according to weight proportion described in formula, Herba Galii Teneri 35g, Herba oxytropis glabrae 35g, Radix rhamni crenatae 35g, Herba phlomidis 35g, Radix desmodiik microphylli 35g, Radix araliae armatae 35g, Radix Zanthoxyli Avicennae 35g, Radix sassafratis 35g, Radix vitis flexuosae 35g, Herba hemipharagmatis heterophylli 35g, Folium Celastri Orbiculati 35g, Radix Celastri Orbiculati 35g, Radix Nandinae Domesticae 35g, Herba Moghaniae fruticulosa 35g, Radix Ophiopogonis Dracaenoidis 25g, Folium Ginseng 25g, Folium Pruni pseudocerasi 25g, Herba Phyllanthi matsumuraes 25g, Radix ipomoeae aquaticae 25g, Caulis Exbucklandiae Populneae 25g, Herba Equiseti Palustris 25g, Herba Pachysandrae Stylosae 25g, Ramulus et Folium Euryae Japonicae 25g, Fructus Anisi Stellati 25g, Folium Et Cacumen Murrayae 25g, Pericarpium Zanthoxyli 25g, Radix Ginseng 25g, Arillus Longan 25g, Fructus Mori 25g, coarser powder is ground into after being dried by ready Chinese medicine, bind up with gauze the container being placed in sealing, add in the Chinese liquor of 10 times amount and leave standstill immersion 50 days, after medicinal material coarse powder is fully expanded, waste, leach clear liquid medicine and namely obtain medicated wine finished product.
Treatment model case: king female 55 years old.In March, 2013, patient occurs that left limb is walked lamely, walking pain obviously shows, function limitation of squatting down, groin mid point tenderness, hip abduction, outward turning is limited, and the test of " 4 " word is positive, and pass internode is hidden broadening, the change in wave shape of femoral head epiphysis, is fragmented into three pieces, is diagnosed as left femoral head necrosis.Take after medicated wine of the present invention treats one month, film making shows that femoral head epiphysis has growth, and density takes a turn for the better, bone density of making film after three months is normal, walk lamely and disappear, check X-ray film after four months, femoral head form is good, epiphysis is round and smooth, the clear wash rice of bone trabecula, joint space is normal, consolidates a course for the treatment of of medication, clinical cure, drug withdrawal.
embodiment 4, formula:radix Schefflerae Delavayi 38g, Herba Galii Teneri 38g, Herba oxytropis glabrae 38g, Radix rhamni crenatae 38g, Herba phlomidis 38g, Radix desmodiik microphylli 38g, Radix araliae armatae 38g, Radix Zanthoxyli Avicennae 38g, Radix sassafratis 38g, Radix vitis flexuosae 38g, Herba hemipharagmatis heterophylli 38g, Folium Celastri Orbiculati 38g, Radix Celastri Orbiculati 38g, Radix Nandinae Domesticae 38g, Herba Moghaniae fruticulosa 38g, Radix Ophiopogonis Dracaenoidis 28g, Folium Ginseng 28g, Folium Pruni pseudocerasi 28g, Herba Phyllanthi matsumuraes 28g, Radix ipomoeae aquaticae 28g, Caulis Exbucklandiae Populneae 28g, Herba Equiseti Palustris 28g, Herba Pachysandrae Stylosae 28g, Ramulus et Folium Euryae Japonicae 28g, Fructus Anisi Stellati 28g, Folium Et Cacumen Murrayae 28g, Pericarpium Zanthoxyli 28g, Radix Ginseng 28g, Arillus Longan 28g, Fructus Mori 28g,
The form of Chinese drug of the present embodiment Chinese medicine composition is honey refining pill, and its preparation method comprises:
Get crude drug Radix Schefflerae Delavayi 38g, Herba Galii Teneri 38g, Herba oxytropis glabrae 38g, Radix rhamni crenatae 38g, Herba phlomidis 38g, Radix desmodiik microphylli 38g, Radix araliae armatae 38g, Radix Zanthoxyli Avicennae 38g, Radix sassafratis 38g, Radix vitis flexuosae 38g, Herba hemipharagmatis heterophylli 38g, Folium Celastri Orbiculati 38g, Radix Celastri Orbiculati 38g, Radix Nandinae Domesticae 38g, Herba Moghaniae fruticulosa 38g, Radix Ophiopogonis Dracaenoidis 28g, Folium Ginseng 28g, Folium Pruni pseudocerasi 28g, Herba Phyllanthi matsumuraes 28g, Radix ipomoeae aquaticae 28g, Caulis Exbucklandiae Populneae 28g, Herba Equiseti Palustris 28g, Herba Pachysandrae Stylosae 28g, Ramulus et Folium Euryae Japonicae 28g, Fructus Anisi Stellati 28g, Folium Et Cacumen Murrayae 28g, Pericarpium Zanthoxyli 28g, Radix Ginseng 28g, Arillus Longan 28g, Fructus Mori 28g adds the 60-90% soak with ethanol 1-2 hour of 5-10 times amount, heating extraction 1-2 hour, remove supernatant, mass continues heating and is concentrated into extractum shape, stand for standby use, become component 1, 1-2 hour soaked by medicinal residues, extract twice, each 1-1.5 hour, merge extractive liquid, 80-120 order filters, be the ultrafiltration post ultrafiltration of 5000-10000 again through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.36 extractum, heating is concentrated, 30 minutes ~ 45 minutes, extract active ingredient, concentrated solution is settled into extractum shape, as component 2, above-mentioned two kinds of extractum are condensed into pasty state, add Mel and be twisted into pill.
Treatment model case: Zheng female 50 years old.General joint pain recurrent exerbation 5 years, limbs are heavy, and morning rises stiff, joint joint stuffiness, meet cold rnning weight.Chemical examination: erythrocyte sedimentation rate 50mm/h, anti-" 0 " 800 unit, rheumatoid factor negative.Clinical diagnosis: rheumatic arthritis, it is sick that card belongs to cold warm numbness.Take the present embodiment Chinese medicine honey refining pill, after 30 days, arthralgia alleviates, and after adhering to medication 3 wheat harvesting period continuously, play stiff all diseases in arthralgia, morning and disappear, functional rehabilitation, laboratory indexes is all normal.
embodiment 5, formula:radix Schefflerae Delavayi 40g, Herba Galii Teneri 40g, Herba oxytropis glabrae 40g, Radix rhamni crenatae 40g, Herba phlomidis 40g, Radix desmodiik microphylli 40g, Radix araliae armatae 40g, Radix Zanthoxyli Avicennae 40g, Radix sassafratis 40g, Radix vitis flexuosae 40g, Herba hemipharagmatis heterophylli 40g, Folium Celastri Orbiculati 40g, Radix Celastri Orbiculati 40g, Radix Nandinae Domesticae 40g, Herba Moghaniae fruticulosa 40g, Radix Ophiopogonis Dracaenoidis 30g, Folium Ginseng 30g, Folium Pruni pseudocerasi 30g, Herba Phyllanthi matsumuraes 30g, Radix ipomoeae aquaticae 30g, Caulis Exbucklandiae Populneae 30g, Herba Equiseti Palustris 30g, Herba Pachysandrae Stylosae 30g, Ramulus et Folium Euryae Japonicae 30g, Fructus Anisi Stellati 30g, Folium Et Cacumen Murrayae 30g, Pericarpium Zanthoxyli 30g, Radix Ginseng 30g, Arillus Longan 30g, Fructus Mori 30g,
The present embodiment Chinese medicine composition is capsule, and its preparation method comprises:
Fructus Anisi Stellati 30g, Pericarpium Zanthoxyli 30g are put into 10 times amount ethanol, heating and refluxing extraction 2 times, each 1 ~ 2 hour, extract active ingredient, 2 extracting solution are merged and leaves standstill, by Radix Schefflerae Delavayi 40g, Herba Galii Teneri 40g, Herba oxytropis glabrae 40g, Radix rhamni crenatae 40g, Herba phlomidis 40g, Radix desmodiik microphylli 40g, Radix araliae armatae 40g, Radix Zanthoxyli Avicennae 40g, Radix sassafratis 40g, Radix vitis flexuosae 40g, Herba hemipharagmatis heterophylli 40g, Folium Celastri Orbiculati 40g, Radix Celastri Orbiculati 40g, Radix Nandinae Domesticae 40g, Herba Moghaniae fruticulosa 40g, Radix Ophiopogonis Dracaenoidis 30g, Folium Ginseng 30g, Folium Pruni pseudocerasi 30g, Herba Phyllanthi matsumuraes 30g, Radix ipomoeae aquaticae 30g, Caulis Exbucklandiae Populneae 30g, Herba Equiseti Palustris 30g, Herba Pachysandrae Stylosae 30g, Ramulus et Folium Euryae Japonicae 30g, Folium Et Cacumen Murrayae 30g, Radix Ginseng 30g, Arillus Longan 30g, Fructus Mori 30g adds in 10 times of water gagings, heating and refluxing extraction 3 times, each 45 minutes ~ 1 hour, 3 extracting solution are merged and leaves standstill, by the merging of above-mentioned two kinds of filtrates, decompression recycling ethanol to be concentrated into liquor strength be 0.4g crude drug/mL, after sucking filtration, when the relative density of filtrate is about 20 DEG C 1.06, above-mentioned filtrate is the macroporous adsorptive resins of 10L through volume, first uses deionized water or the distilled water eluting of 10 times of resin column volumes, then uses 95% ethanol elution of 5 times of resin column volumes, collects ethanol elution, removes solvent, obtains raw material medicated powder, incapsulate.
Treatment model case: female Lee 37 years old.Suffer from rheumatoid arthritis 13 years, the swelling of Lai Zhenshi main suit's arthralgia, muscle is numb, the migrans pain of whole body, and finger-joint is out of shape, and getting up early is stiff serious for morning, and activity of getting up is to afternoon, and symptom could be alleviated, chemical examination: erythrocyte sedimentation rate 50mm/h, rheumatoid factor positive.Clinical diagnosis: rheumatoid arthritis, takes after the present embodiment capsule treats two months, arthralgia, numbness, morning stiff symptom all disappear, rheumatoid factor chemical examination is negative, reach clinical cure standard, take two courses for the treatment of afterwards and consolidated, pay a return visit and do not recur so far.
pharmacology pharmacodynamic is tested:
1, acute toxicity test
Application mice carries out acute toxicity testing and shows: the Traditional Chinese medicine preparation capsule agent of the present invention of Mouse oral gavage, under 488.8g crude drug/kg dosage, after administration, mice occurs that light activity reduces, 1 hours recovers normal, Continuous Observation 7 days after administration, none animal dead, its overall health of patients, diet, take the photograph water, urine and body weight increase all normal, experimental result shows: the maximum dosage-feeding of Mouse oral gavage Traditional Chinese medicine preparation capsule agent of the present invention is 488.8g crude drug/kg/d (LD 50 > 488.8g crude drug/kg).Chinese medicine preparation clinical application every day total amount of the present invention is 0.1g crude drug/kg/d; By weighing machine, the dosis tolerata of mouse stomach Chinese medicine preparation of the present invention is 4888 times of clinical patient.Point out this medicine acute toxicity low, clinical drug safety.
, long term toxicity test
Select SD rat, give the Chinese medicine preparation pill of the present invention of variable concentrations (18.0,6.0,2.0g crude drug/kg), every day gavage once, continuous 90 days, within after last administration 24 hours, respectively group is alive kills 1/2 animal (male and female half and half), and all the other 1/2 animals continue observations 2 weeks rear living and kill.Duration of test observes outward appearance, general behavior, food ration, the body weight change of animal, within after administration 90 days, within 2 weeks, carries out the index checking such as hematology's (RBC, HB, reticulocyte, PLT, CT, WBC and classification) and blood biochemical (AST, ALT, ALP, Glu, BUN, Crea, TP, T.BIL, ALB, CHOL), urine biochemistry, organ coefficient, histopathology with drug withdrawal.Result of the test shows: invention formulation is good at high, medium and low dosage treated animal general state, and outward appearance sign, behavioral activity, food-intake and body weight increase change all without exception; Three dosage groups and matched group hematological examination, blood biochemical analysis, urine biochemical analysis all in normal range, without significant difference between group; Each group of main organs histopathological examination shows no obvious abnormalities.These parameters drug withdrawal also had no change after 2 weeks.This test dosage is respectively 180,60,20 times of clinical medicine dose, rat is had no significant effect in high, medium and low three dosage (18.0,6.0,2.0g crude drug/kg) administration in continuous 90 days according to result of the test Chinese medicine preparation of the present invention, without clear and definite toxicity target organ and sensitive indicator, convalescent period observation also has no retardance toxic reaction, points out the dose safety of Chinese medicine preparation clinical practice of the present invention higher.
, animal local excitation test:
The allergic reaction on guinea pigs of medicated wine agent of the present invention and honey refining pill Rat-rectum medication irritation test.Result shows: skin anaphylactic test, high dose group 0.8g (medicated powder)/kg, low dose group 0.1g (medicated powder)/kg, be equivalent to 20 times, 2.5 times that intend clinical people's consumption [0.04g (medicated powder)/kg] respectively, through percutaneous drug delivery, be showed no animal and produce allergy; Rectal application irritation test high dose group 5.0g (medicated powder)/kg, low dose group 3.2g (medicated powder)/kg, be equivalent to 125,80 times that intend clinical people's consumption respectively, mucous membrane of rectum is observed all without phenomenons such as hyperemia, edema in official hour, histopathologic examination compares no significant difference with blank group, have no and occur obvious irritative response, often organize its overall health of patients of Some Animals of retention, body weight, breathing, circulation, central nervous system and extremity are movable, equal Non Apparent Abnormality reaction.
clinical data
1.1 physical data choose patient 100 example being diagnosed as rheumatic arthralgia (rheumatic arthritis) altogether, adopt random digits table to be divided into treatment group and matched group at random, two groups of each 50 examples, wherein treatment group man 30 example, female 20 example; 22-60 years old ages; Matched group man 33 example, female 17 example, 21-59 years old ages, two groups of ages, sex through statistical procedures, no significant difference (P>0.05).
1.2 diagnostic criteria
1.2.1 Western medicine diagnose standard is drafted with reference to " new Chinese medicine guideline of clinical investigations ".(1) symptom and sign: the periodicity of prolonged and repeated generation, rhythmicity muscles and bones muscle arthrosis pain, applying the medicine that relieves the pain can alleviate; Numbness, body are unfavorable, arthroncus (2) auxiliary examination: X-ray film, the inspection such as femoral head, joint space.
1.2.2 the diagnostic criteria of traditional Chinese medical science rheumatic arthralgia card is with reference to " guideline of clinical investigations of new Chinese medicine treatment rheumatic arthralgia card ".
1.3 case inclusive criterias are all meets two doctor's Disease Diagnosis Standards and TCM Syndrome Type diagnostic criteria and outside exclusion standard, and age person between 20-60 years old all can be used as and includes case in.Participate in experimenter and all sign Informed Consent Form.
1.4 case exclusion standard (1) anemia of pregnant woman, women breast-feeding their children or may conceived person at period in a medicine.(2) there are other complication to affect the treatment and observe or have the disease of taboo to observing medicine.(3) other organ serious diseases person that needs medication treatment is had.(4) not by regulation medication, cannot judge that curative effect or data are not congruent and affect the treatment or safety judgement person.
2 Therapeutic Method
2.1 treatment groups give prescription embodiment 1 to 5 formula agent of the present invention, and capsule and pill 1 dose/d, take at twice, within 15 days, are 1 course for the treatment of; Medicated wine agent 15g/ time, 3 times/day 15 days was 1 course for the treatment of.
2.2 matched groups give Hp positive and add with ibuprofen 0.5 g, oral, 3 times/d; Paste analgesic extract, 1 day/1 pastes, and within 15 days, is 1 course for the treatment of.
3 observation of curative effect
3.I observation item (1) tcm syndrome observes weekly its change.(2) time of panic attacks, number of times, degree, persistent period, induced factor.(3) sign: blood pressure, pulse, body temperature, breathing, tongue, arteries and veins.
The general health check-up project of 3.2 security inspections (1).(2) X-ray function.
3.3 criterion of therapeutical effect
3.3.I curative effect determinate standard is divided into four grade standards (1) clinical recovery.(2) effective.(3) effective.(4) invalid.
3.3.2 therapeutic effect of syndrome criterion is formulated with reference to " new Chinese medicine guideline of clinical investigations " l.Statistics symptom improve integration (primary symptom is divided gently, in, heavily respectively count 3 points, 5 points, 7 points, secondary disease counts 1 point, 2 points, 3 points respectively, asymptomatic meter zero), namely check after 1 course for the treatment of terminated, add up total effective rate; Cure and follow up a case by regular visits to for latter 1 year, reviewing statistics relapse rate.
3.4 statistical procedures all data acquisition SPSS12.0 statistical software adds up, and before and after treatment, data compare employing x inspection and t inspection, and group is asked to compare and analyzed with Ridit.
3.5 therapeutic outcomes are in table 1-3.
A table 1 liang group total effective rate compares (example)
Group n Recovery from illness Effective Effectively Invalid Total effective rate (%)
Treatment group 50 34 11 2 3 94
Matched group 50 26 12 5 7 86
Table 1 statistical analysis is pointed out: the total effective rate for the treatment of group and treatment of control group rheumatic Bi syndrome compares, the equal not statistically significant of difference (P>0.05).
A table 2 liang group Chinese medicine syndrome integral compares (x ± s, point)
Group n Before treatment After treatment
Treatment group 50 25.21±2.5 11.81±2.42
Matched group 50 24.41±1.34 12.51±2.54
Table 2 statistical analysis is pointed out: treat front two groups of integration no significant difference, after treatment, two groups of integrations are compared with before treatment, difference all has statistical significance (P<0.01), two groups of integral contrasts after treatment, difference has statistical significance (P<0.05).
After table 3 liang organizes 1 year, relapse rate compares (example)
Group n Recurrence Recovery from illness Relapse rate (%)
Treatment group 50 5 45 10
Matched group 50 9 41 18
Table 3 statistical analysis is pointed out: treatment group relapse rate compares with matched group, and difference has statistical significance (P<0.05).
All above-mentioned this intellectual properties of primary enforcement, not setting restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.
The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.

Claims (10)

1. treat a Chinese medicine composition for rheumatic arthralgia, it is characterized in that: in described Chinese medicine composition, the ratio of weight and number of various crude drug is:
Radix Schefflerae Delavayi 30-40 part, Herba Galii Teneri 30-40 part, Herba oxytropis glabrae 30-40 part, Radix rhamni crenatae 30-40 part, Herba phlomidis 30-40 part, Radix desmodiik microphylli 30-40 part, Radix araliae armatae 30-40 part, Radix Zanthoxyli Avicennae 30-40 part, Radix sassafratis 30-40 part, Radix vitis flexuosae 30-40 part, Herba hemipharagmatis heterophylli 30-40 part, Folium Celastri Orbiculati 30-40 part, Radix Celastri Orbiculati 30-40 part, Radix Nandinae Domesticae 30-40 part, Herba Moghaniae fruticulosa 30-40 part, Radix Ophiopogonis Dracaenoidis 20-30 part, Folium Ginseng 20-30 part, Folium Pruni pseudocerasi 20-30 part, Herba Phyllanthi matsumuraes 20-30 part, Radix ipomoeae aquaticae 20-30 part, Caulis Exbucklandiae Populneae 20-30 part, Herba Equiseti Palustris 20-30 part, Herba Pachysandrae Stylosae 20-30 part, Ramulus et Folium Euryae Japonicae 20-30 part, Fructus Anisi Stellati 20-30 part, Folium Et Cacumen Murrayae 20-30 part, Pericarpium Zanthoxyli 20-30 part, Radix Ginseng 20-30 part, Arillus Longan 20-30 part, Fructus Mori 20-30 part.
2. a kind of Chinese medicine composition for the treatment of rheumatic arthralgia according to claim 1, is peculiarly: in described Chinese medicine composition, the ratio of weight and number of various crude drug is:
Radix Schefflerae Delavayi 32-38 part, Herba Galii Teneri 32-38 part, Herba oxytropis glabrae 32-38 part, Radix rhamni crenatae 32-38 part, Herba phlomidis 32-38 part, Radix desmodiik microphylli 32-38 part, Radix araliae armatae 32-38 part, Radix Zanthoxyli Avicennae 32-38 part, Radix sassafratis 32-38 part, Radix vitis flexuosae 32-38 part, Herba hemipharagmatis heterophylli 32-38 part, Folium Celastri Orbiculati 32-38 part, Radix Celastri Orbiculati 32-38 part, Radix Nandinae Domesticae 32-38 part, Herba Moghaniae fruticulosa 32-38 part, Radix Ophiopogonis Dracaenoidis 22-28 part, Folium Ginseng 22-28 part, Folium Pruni pseudocerasi 22-28 part, Herba Phyllanthi matsumuraes 22-28 part, Radix ipomoeae aquaticae 22-28 part, Caulis Exbucklandiae Populneae 22-28 part, Herba Equiseti Palustris 22-28 part, Herba Pachysandrae Stylosae 22-28 part, Ramulus et Folium Euryae Japonicae 22-28 part, Fructus Anisi Stellati 22-28 part, Folium Et Cacumen Murrayae 22-28 part, Pericarpium Zanthoxyli 22-28 part, Radix Ginseng 22-28 part, Arillus Longan 22-28 part, Fructus Mori 22-28 part.
3. a kind of Chinese medicine composition for the treatment of rheumatic arthralgia according to claim 1 or 2, is peculiarly: in described Chinese medicine composition, the ratio of weight and number of various crude drug is:
Radix Schefflerae Delavayi 35 parts, Herba Galii Teneri 35 parts, Herba oxytropis glabrae 35 parts, Radix rhamni crenatae 35 parts, Herba phlomidis 35 parts, Radix desmodiik microphylli 35 parts, Radix araliae armatae 35 parts, Radix Zanthoxyli Avicennae 35 parts, Radix sassafratis 35 parts, Radix vitis flexuosae 35 parts, Herba hemipharagmatis heterophylli 35 parts, Folium Celastri Orbiculati 35 parts, Radix Celastri Orbiculati 35 parts, Radix Nandinae Domesticae 35 parts, Herba Moghaniae fruticulosa 35 parts, Radix Ophiopogonis Dracaenoidis 25 parts, Folium Ginseng 25 parts, Folium Pruni pseudocerasi 25 parts, Herba Phyllanthi matsumuraes 25 parts, Radix ipomoeae aquaticae 25 parts, Caulis Exbucklandiae Populneae 25 parts, Herba Equiseti Palustris 25 parts, Herba Pachysandrae Stylosae 25 parts, Ramulus et Folium Euryae Japonicae 25 parts, Fructus Anisi Stellati 25 parts, Folium Et Cacumen Murrayae 25 parts, 25 parts, Pericarpium Zanthoxyli, Radix Ginseng 25 parts, Arillus Longan 25 parts, 25 parts, Fructus Mori.
4. a kind of preparation method for the treatment of the Chinese medicine composition of rheumatic arthralgia according to any one of claims 1 to 3, is characterized in that: the form of Chinese drug of described Chinese medicine composition is honey refining pill, and its preparation method comprises:
A, get crude drug and put into soak with ethanol, heat is extracted 1 time, and becoming extractum shape, is component 1;
B, medicinal residues extracting in water 2 times, thickening filtration is extractum shape, is component 2;
C, above-mentioned two kinds of extractum are condensed into pasty state, add Mel and be twisted into pill.
5. according to preparation method described in claim 4, it is characterized in that, in described step a, can get the 60-90% soak with ethanol 1-2 hour that crude drug adds 5-10 times amount, heating extraction 1-2 hour, removes supernatant, mass continues heating and is concentrated into extractum shape, stand for standby use, becomes component 1.
6. according to preparation method described in claim 4, it is characterized in that, in described step b, medicinal residues can be soaked 1-2 hour, extract twice, each 1-1.5 hour, merge extractive liquid, 80-120 order filters, then is the ultrafiltration post ultrafiltration of 5000-10000 through the molecular weight that dams, when ultrafiltrate concentrating under reduced pressure relative density is 80 DEG C 1.36 extractum, heating is concentrated, 30 minutes ~ 45 minutes, extracts active ingredient, concentrated solution is settled into extractum shape, as component 2.
7. a kind of preparation method for the treatment of the Chinese medicine composition of rheumatic arthralgia according to any one of claims 1 to 3, is characterized in that, the form of Chinese drug of described Chinese medicine composition is capsule, and its preparation method comprises:
A, Fructus Anisi Stellati and Pericarpium Zanthoxyli are put into ethanol heating and refluxing extraction;
B, get surplus stock in above-mentioned side again, add water heating and refluxing extraction;
C, above-mentioned two kinds of extracting solution to be merged, decompression recycling ethanol concentrated sucking filtration absorption, obtain crude drug; Canned.
8. preparation method according to claim 7, is characterized in that, in described step a, Fructus Anisi Stellati and Pericarpium Zanthoxyli can be put into 10 times amount ethanol, heating and refluxing extraction 2 times, each 1 ~ 2 hour, extracts active ingredient, is merged by 2 extracting solution and leaves standstill; In described step b, by surplus stock 10 times of water gagings, 3 extracting solution each 45 minutes ~ 1 hour, are merged and leave standstill by heating and refluxing extraction 3 times.
9. preparation method according to claim 7, is characterized in that, in described step c, can by the merging of above-mentioned two kinds of filtrates, and decompression recycling ethanol to be concentrated into liquor strength be 0.4g crude drug/mL, after sucking filtration, when the relative density of filtrate is about 20 DEG C 1.06; Above-mentioned filtrate is the macroporous adsorptive resins of 10L through volume, first uses deionized water or the distilled water eluting of 10 times of resin column volumes, then uses 95% ethanol elution of 5 times of resin column volumes, collects ethanol elution, removes solvent, obtains raw material medicated powder, incapsulate.
10. a kind of preparation method for the treatment of the Chinese medicine composition of rheumatic arthralgia according to any one of claims 1 to 3, is peculiarly, the form of Chinese drug of described Chinese medicine composition is medicated wine agent, and its preparation method comprises:
Each crude drug is taken according to weight proportion described in formula, be ground into coarser powder after being dried by ready Chinese herbal medicine, bind up with gauze the container being placed in sealing, add in the Chinese liquor of 10 times amount and leave standstill immersion 50 days, after medicinal material coarse powder is fully expanded, waste, leach clear liquid medicine and namely obtain medicated wine finished product.
CN201510034659.3A 2015-01-23 2015-01-23 Traditional Chinese medicine composition for treating rheumatic arthralgia and preparation method thereof Pending CN104524174A (en)

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104815318A (en) * 2015-05-27 2015-08-05 杜小卫 Traditional Chinese medicine preparation for treating gout
CN104825891A (en) * 2015-05-20 2015-08-12 韩立红 Traditional Chinese medicine preparation for treating epilepsy
CN105456533A (en) * 2015-12-28 2016-04-06 青岛昌安达药业有限公司 Traditional Chinese medicine formula for treating ankylosing spondylitis

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1557451A (en) * 2004-01-16 2004-12-29 万忠琦 Dog bone contained composition for treating rheumatoid arthritis
CN101357168A (en) * 2008-09-16 2009-02-04 朱惠芬 Medicinal wine for treating rheumatic arthritis
CN103285206A (en) * 2013-07-05 2013-09-11 梁怡芃 Traditional Chinese medicinal liquor for treating rheumatic arthritis

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1557451A (en) * 2004-01-16 2004-12-29 万忠琦 Dog bone contained composition for treating rheumatoid arthritis
CN101357168A (en) * 2008-09-16 2009-02-04 朱惠芬 Medicinal wine for treating rheumatic arthritis
CN103285206A (en) * 2013-07-05 2013-09-11 梁怡芃 Traditional Chinese medicinal liquor for treating rheumatic arthritis

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104825891A (en) * 2015-05-20 2015-08-12 韩立红 Traditional Chinese medicine preparation for treating epilepsy
CN104815318A (en) * 2015-05-27 2015-08-05 杜小卫 Traditional Chinese medicine preparation for treating gout
CN105456533A (en) * 2015-12-28 2016-04-06 青岛昌安达药业有限公司 Traditional Chinese medicine formula for treating ankylosing spondylitis

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Application publication date: 20150422