CN106938048A - A kind of Chinese medicine preparation for treating cardiovascular and cerebrovascular disease - Google Patents

A kind of Chinese medicine preparation for treating cardiovascular and cerebrovascular disease Download PDF

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CN106938048A
CN106938048A CN201710233891.9A CN201710233891A CN106938048A CN 106938048 A CN106938048 A CN 106938048A CN 201710233891 A CN201710233891 A CN 201710233891A CN 106938048 A CN106938048 A CN 106938048A
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cerebrovascular disease
blood
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王敬顺
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Abstract

The present invention provides a kind of Chinese medicine preparation for treating cardiovascular and cerebrovascular disease, is made up of the medicine of following weight：150 grams of the red sage root, 100 grams of rhizoma Gastrodiae, 200 grams of pseudo-ginseng, 100 grams of hawthorn, 150 grams of American Ginseng, 100 grams of RADIX POLYGONI MULTIFLORI PREPARATA, 150 grams of decumbent corydalis tuber, 50 grams of ground dragon protein, 50 grams of hirudin, 20 grams of snakegourd extract, 20 grams of ginkgo biloba p.e, 20 grams of kudzu root extract, 20 grams of erigeron breviscapus extract.The medicine of prescription of the present invention, with relaxing the muscles and stimulate the blood circulation, promote blood circulation dredging collateral, antithrombotic, anticoagulant, it is promoting blood circulation and removing blood stasis, effect of lipid-loweringing hypotensive, can effectively treat that hypertension, high fat of blood, blood is viscous, cerebral infarction, heart infarction, and cure rate is more than 90%, it is the special effect medicine for treating cardiovascular and cerebrovascular disease, safety is without any side effects.

Description

A kind of Chinese medicine preparation for treating cardiovascular and cerebrovascular disease
Technical field
The present invention relates to technical field of traditional Chinese medicines, particularly a kind of Chinese medicine preparation for treating cardiovascular and cerebrovascular disease.
Background technology
Cardiovascular and cerebrovascular disease refer to heart and arteries harden caused by heart ischemia or the disease of bleeding, bag Coronary heart diseases and angina pectoris, hypertension, arrhythmia cordis, miocardial infarction, cerebral infarction is included to wait indefinitely.Cardiovascular and cerebrovascular disease is known as threat people always The number one killer of class health, hypertension, high fat of blood, coronary heart disease, diabetes turn into " pestilence in epoch ".According to the World Health Organization The numeral of issue, last year, the global number dead because of cardiovascular and cerebrovascular disease accounted for 1/3rd of global death.Cardiovascular and cerebrovascular diseases are accounted for The population of China cause of the death is the first.It is cardiovascular with the growth of the average life span, the affluence of material conditions and the change of life culture mode Disease, particularly Incidence of CHD and the death rate are increasing year by year, thus cardioprotection, treatment cardiovascular and cerebrovascular disease are more and more It is taken seriously and is concerned about.Although the medicament categories currently used for treatment cardiovascular and cerebrovascular disease are more, research and development are efficiently pacified Full cardiovascular medicament is still the task of top priority, is also the subject that country supports to advocate energetically.
At present treatment coronary heart disease, cerebral infarction, cerebral hemorrhage and sequelae medicament categories it is various, but this similar drug is pharmacologically all It is that respite is reached by expansion of blood vessels, it is impossible to be effectively accomplished the intravascular rubbish of removing, reduction blood fat, blood pressure are thoroughly extensive The purpose of rehabilitation health, and easily leave serious sequelae and side effect, also has blood vessel, stent in the treatment are changed by performing the operation in addition Mode, but this medical expense is expensive, and general patient is difficult to bear.
The content of the invention
In order to overcome the deficiencies in the prior art, the invention provides a kind of safe and effective, the treatment heart and brain having no toxic side effect The pure Chinese medicinal preparation of vascular diseases.
The technical solution adopted for the present invention to solve the technical problems is：
The present invention provides a kind of Chinese medicine preparation for treating cardiovascular and cerebrovascular disease, is made up of the medicine of following weight： 140~160 parts of the red sage root, 95~105 parts of rhizoma Gastrodiae, 195~205 parts of pseudo-ginseng, 95~105 parts of hawthorn, 145~155 parts of American Ginseng, system 95~105 parts of the tuber of multiflower knotweed, 145~155 parts of decumbent corydalis tuber, 45~55 parts of ground dragon protein, 45~55 parts of hirudin, snakegourd extract 15~ 25 parts, 5~25 parts of ginkgo biloba p.e, 5~25 parts of kudzu root extract, 5~25 parts of erigeron breviscapus extract.
It is used as further preferred embodiment, the Chinese medicine preparation of the treatment cardiovascular and cerebrovascular disease, by following parts by weight The medicine composition of proportioning：150 grams of the red sage root, 100 grams of rhizoma Gastrodiae, 200 grams of pseudo-ginseng, 100 grams of hawthorn, 150 grams of American Ginseng, RADIX POLYGONI MULTIFLORI PREPARATA 100 Gram, 150 grams of decumbent corydalis tuber, 50 grams of ground dragon protein, 50 grams of hirudin, 20 grams of snakegourd extract, 20 grams of ginkgo biloba p.e, the root of kudzu vine is carried Take 20 grams of thing, 20 grams of erigeron breviscapus extract.
As further preferred embodiment, the snakegourd extract, ginkgo biloba p.e, kudzu root extract, oil lamp Herba Asari extract, which is, uses supercritical CO2The extract that extracting process is obtained.
As further preferred embodiment, the Chinese medicine preparation is pill.
The preparation method of the Chinese medicine preparation of above-mentioned treatment cardiovascular and cerebrovascular disease is：By the red sage root of corresponding parts by weight, rhizoma Gastrodiae, three 7th, hawthorn, American Ginseng, RADIX POLYGONI MULTIFLORI PREPARATA, decumbent corydalis tuber, low temperature play the sieving of the mesh of powder 100 after baking and banking up with earth, ground dragon protein with corresponding parts by weight, Hirudin, snakegourd extract, ginkgo biloba p.e, kudzu root extract, erigeron breviscapus extract are well mixed, and take high-quality honey to refine To micro- yellow foaming, 6mm water-honeyed pills, drying sterile filling of bottles with are made after mediation.
Wherein, snakegourd extract, ginkgo biloba p.e, kudzu root extract, erigeron breviscapus extract described in we, be With supercritical CO2Abstraction technique, close to room temperature (35~40 DEG C) and CO2Extracted under gas blanket, effectively prevent heat The oxidation and loss of quick property material, remain the active ingredient of medicinal plant in extract, and can be higher boiling, low volatilization Property, the material being easily pyrolyzed are extracted under far below its boiling temperature.Following extraction steps can be used：Using HA121-50- O1 types supercritical extraction unit (Nantong Huaan is overcritical to going to Co., Ltd to produce), weighs raw material powder and loads barrel, then Barrel is loaded into extraction kettle, pressure ring and sealing ring is installed, plug is screwed, supercritical extract instrument is then turned on, at 35~40 DEG C Lower extraction 1.5~2.5 hours, extracting pressure is 32~38MPa, and solid-liquid ratio is (inventory and entrainer weight ratio) 300:350； Collect extract solution, subsequently can it is spray-dried after extract powder is made.Because overall process is without organic solvent, therefore extract The molten material absolutely not remained, so as to prevent the presence of harmful thing and the pollution to environment in extraction process, it is ensured that Pure natural property；Extraction and separation unite two into one, as the CO of the dissolved matter of saturation2When fluid enters separator, due to pressure Decline and the change of temperature so that CO2Two-phase (gas-liquid separation) is rapidly become with extract and is separated immediately, the effect not only extracted Rate is high and energy consumption is less, improves production efficiency and also reduces expense cost；Use supercritical CO2Extract the Chinese medicine effectively into Point, under optimum process condition, the composition of required extraction almost can completely be extracted, so as to greatly improve product yield and resource Utilization rate., can be with by changing temperature or pressure or while change temperature and pressure, can all change solubility in operating process The separation of many kinds of substance in Chinese medicine is selectively carried out, so as to reduce impurity, makes effective component of chinese medicine highly enriched, is easy to subtract Low dose of and control quality, makes product appearance be greatly improved；And operation temperature is low, effective component of chinese medicine can be more fully preserved not It is destroyed, time biochemistry does not occur, extraction time is fast, with short production cycle.Supercritical CO2Extract circulation at the beginning, separation just starts Carry out.General extract just has composition separation precipitation for 10 minutes, just can extract completely within 2~4 hours or so, meanwhile, it is not required to concentration Etc. step, even if adding entrainer, also it can be removed or only need to simply concentrated by separation function；Many tradition can be extracted simultaneously The material that method can not be carried Chu Lai, and be easier to from Chinese medicine find new component, so as to find new pharmacological property, developing new drug；It is super Critical CO2Also there are anti-oxidant, sterilization functions, the quality of product is advantageously ensured that and improve；It is super to face through pharmacology, clinical proof Boundary CO2The effective extract of the present invention extracted, not only superior in technique, steady quality, and standard are easily controlled, its medicine Reason, clinical effectiveness can be more preferable.We make modern technologies be combined with traditional handicraft, supercritical CO will be used in Chinese medicine2Extraction The active ingredient of technology abstract is 10 by weight:1 ratio (the weight ratio of raw material and abstract) proposes to use, it is ensured that medicine The active ingredient of thing is maximum and succinct use.
In prescription of the present invention, the red sage root：Bitter, is slightly cold, and thoughts of returning home Liver Channel, dissolving stasis relieves the pain, invigorate blood circulation, relieving restlessness that clears away heart-fire.
Pseudo-ginseng：Sweet, slight bitter is warm-natured, Return liver, stomach, the heart, lung, large intestine channel, dissipates blood, and analgesic therapy is flutterred the stasis of blood and swollen, the obstruction of qi in the chest twists pain, disease Lump in the abdomen, blood stasis.
Rhizoma Gastrodiae：Mild-natured, sweet, micro-pungent, return liver warp, suppressing hyperactive liver for calming endogenous wind, tranquilizing and allaying excitement can increase CBF, reduce the cerebrovascular Resistance, reduces blood pressure, reducing heart rate.
Hawthorn：It is sour, sweet, tepor, returns spleen stomach Liver Channel, food digesting stomach fortifying, scattered stasis.
American Ginseng：Sweet, slight bitter is cold in nature, beneficial Yin and promoting production of body liquid, tonifying Qi, anti-arrhythmia, myocardial ischemia, reconciles blood pressure, reduction Blood clotting, suppresses platelet aggregation, anti arteriosclerosis.
RADIX POLYGONI MULTIFLORI PREPARATA：Bitter, sweet, puckery, warm-natured flat, filling liver kidney, benefiting essence-blood changes turbid lipid-loweringing.
Decumbent corydalis tuber：Bitter, micro-pungent, temperature, promoting blood circulation and removing obstruction in channels, promoting the circulation of qi relieves the pain, hypotensive, calm, stimulates the circulation of the blood and cause the muscles and joints to relax.
Snakegourd：It is sweet, bitter cold, moistening lung for removing phlegm, dissipating bind.
The root of kudzu vine：Sweet, pungent, cool, returns spleen stomach, expelling pathogenic factors from muscles and skin promotes the production of body fluid, step-down of bringing down a fever.
Erigeron breviscapus：Pungent, slight bitter is warm-natured, expelling cold and relieving exterior syndrome, and dispelling wind and eliminating dampness is active, and the cerebrovascular causes hemiplegia.
Ginkgo leaf：It is sweet, it is bitter, it is puckery, it is promoting blood circulation and removing blood stasis, relieve the pain, reducing blood lipid.
Ground dragon protein：Tasteful, heat-clearing dredging collateral, thrombus, softening blood vessel, drop blood glues, and bidirectional modulation blood pressure improves micro- follow Ring.
Hirudin：It is tasteful, efficient anticoagulation, antithrombotic.
The medicine of prescription of the present invention, using ground dragon protein, hirudin as monarch drug in a prescription, pseudo-ginseng, the red sage root, rhizoma Gastrodiae, hawthorn, oil lamp are thin Pungent, summer inaction ministerial drug, other is adjutant, and preparation nature and flavor are proper, and channel tropism is appropriate, and the monarch and his subjects' assistant is engaged, and with relaxing the muscles and stimulate the blood circulation, is led to Maitong network, antithrombotic, anticoagulant is promoting blood circulation and removing blood stasis, effect of lipid-loweringing hypotensive, can effectively treat hypertension, high fat of blood, blood it is viscous, Cerebral infarction, heart infarction, cure rate are the special effect medicines for treating cardiovascular and cerebrovascular disease more than 90%, and safety is without any side effects.
To show therapeutic effect of the medicine of the present invention to cardiovascular and cerebrovascular disease, the present invention has carried out being up to 5 to 120 patients In the clinical treatment observation in year, 120 patients, male 82, women 38, wherein headstroke 65, coronary heart disease 38 is high Blood pressure high fat of blood 17.
The instructions of taking of medicine of the present invention：
Headstroke：Three times per day, one time 8-9 grams, warm water delivery service two months is a course for the treatment of.
Coronary heart disease：Two times a day, one time 8-9 grams, warm water delivery service two months is a course for the treatment of.
Hypertension, high fat of blood：Two times a day, one time 6 grams, warm water delivery service one month is a course for the treatment of.
Criterion of cure：
Clinical symptom disappearance, electrocardiogram, rheoencephalogram have been become a full member often, and follow-up more than 2 years is without recurrence.
Be clearly better standard：
Clinical symptoms disappear substantially, and electrocardiogram, rheoencephalogram are normal.
The curative effect situation of patient after drug therapy of the present invention see the table below 1：
Table 1
Embodiment
Below to a preferred embodiment of the present invention will be described in detail.
Embodiment 1
The preferred embodiment of the present invention 1 provides a kind of medicine by following weight and constituted：150 grams of the red sage root, rhizoma Gastrodiae 100 Gram, 200 grams of pseudo-ginseng, 100 grams of hawthorn, 150 grams of American Ginseng, 100 grams of RADIX POLYGONI MULTIFLORI PREPARATA, 150 grams of decumbent corydalis tuber, 50 grams of ground dragon protein, leech 50 grams of element, 20 grams of snakegourd extract, 20 grams of ginkgo biloba p.e, 20 grams of kudzu root extract, 20 grams of erigeron breviscapus extract.
Production process：By 150 grams of the red sage root, 100 grams of rhizoma Gastrodiae, 200 grams of pseudo-ginseng, 100 grams of hawthorn, 150 grams of American Ginseng, RADIX POLYGONI MULTIFLORI PREPARATA 100 grams, 150 grams of low temperature of decumbent corydalis tuber play the sieving of the mesh of powder 100 after baking and banking up with earth, with 50 grams of ground dragon protein, 50 grams of hirudin, snakegourd extract 20 grams, 20 grams of ginkgo biloba p.e, 20 grams of kudzu root extract, 20 grams of mixing of erigeron breviscapus extract take high-quality honey to refine to micro- Huang foaming, makes 6mm water-honeyed pills, drying sterile filling of bottles with after mediation.
The snakegourd extract, ginkgo biloba p.e, kudzu root extract, erigeron breviscapus extract are using overcritical CO2The extract that extracting process is obtained.
Embodiment 2
The preferred embodiment of the present invention 2 provides a kind of medicine by following weight and constituted：140 grams of the red sage root, rhizoma Gastrodiae 105 Gram, 195 grams of pseudo-ginseng, 98 grams of hawthorn, 151 grams of American Ginseng, 102 grams of RADIX POLYGONI MULTIFLORI PREPARATA, 153 grams of decumbent corydalis tuber, 48 grams of ground dragon protein, hirudin 46 grams, 19 grams of snakegourd extract, 20 grams of ginkgo biloba p.e, 18 grams of kudzu root extract, 22 grams of erigeron breviscapus extract.
Production process be the same as Example 1.
Embodiment 3
The preferred embodiment of the present invention 3 provides a kind of medicine by following weight and constituted：152 grams of the red sage root, rhizoma Gastrodiae 98 Gram, 203 grams of pseudo-ginseng, 102 grams of hawthorn, 149 grams of American Ginseng, 96 grams of RADIX POLYGONI MULTIFLORI PREPARATA, 147 grams of decumbent corydalis tuber, 54 grams of ground dragon protein, hirudin 53 grams, 21 grams of snakegourd extract, 22 grams of ginkgo biloba p.e, 24 grams of kudzu root extract, 18 grams of erigeron breviscapus extract.
Production process be the same as Example 1.
Comparative example
Comparative example of the present invention provides a kind of medicine by following weight and constituted：150 grams of the red sage root, 100 grams of rhizoma Gastrodiae, three 7 200 grams, 100 grams of hawthorn, 150 grams of American Ginseng, 100 grams of RADIX POLYGONI MULTIFLORI PREPARATA, 150 grams of decumbent corydalis tuber, 50 grams of ground dragon protein, hirudin 50 Gram, 20 grams of snakegourd extract, 20 grams of ginkgo biloba p.e, 20 grams of kudzu root extract, 20 grams of erigeron breviscapus extract.
The snakegourd extract is the snakegourd extract by being extracted after petroleum ether refluxing extraction through chloroform, and the ginkgo leaf is carried It is the ginkgo biloba p.e extracted through ethyl acetate to take thing, and the kudzu root extract is that the root of kudzu vine extracted through 75% ethanol is extracted Thing, the erigeron breviscapus extract is the erigeron breviscapus extract extracted through 60% ethanol, and each extract is dry through spraying Dry rear water content is powdered below 5%.
This comparative example is the preliminary research achievement before the present invention, is controlled using the drugs on patients of this comparative example initial stage The curative effect for the treatment of see the table below 2：
Table 2
Contrasted from Tables 1 and 2, the therapeutic effect of drugs on patients described in the embodiment of the present invention 1, which will be significantly better than, grinds The medicine described in the comparative example used initial stage is studied carefully, the following is using obtaining what is effectively treated after medicine described in the embodiment of the present invention 1 Typical case：
Typical case：
1. Mr. Li, male, 42 years old, Laoshan people.
In patient's night on June 20th, 2013, body sense dizziness and distending sensation of the head, limb adynamia, discomfort uncomfortable in chest suddenly goes local hospital to examine Control, inspection is diagnosed as subacute cerebral infarction, blood pressure 100-170 caused by category hypertension, hyperlipemia, through staying institute to treat two weeks my later institutes The traditional Chinese medical science is sought medical advice, and with the pill administration of the embodiment of the present invention 1, blood pressure is decreased obviously after one week, and dizzy dizziness phenomenon is obviously improved, even Continuous to take after one month, phenomenon dizzy, dizzy, uncomfortable in chest is substantially disappeared, blood pressure 80-140, and (two are taken altogether with two courses for the treatment of are taken Month), blood pressure normal table, blood fat recovers normal, increases again and takes course for the treatment of consolidation.Follow-up after 1 year, all goes well.
2. Liu so-and-so, female, 45 years old, Qingdao people from Chengyang
Patient's late into the night on the 16th of September in 2014, the dizzy pain of sense of dashing forward, limb adynamia, calf is gradually numb, and language has obstacle, Local hospital is suddenly sent to be diagnosed as cerebral hemorrhage, hospitalization one and a half months spends nearly 80,000 yuan.I sought medical advice at institute's traditional Chinese medical science later, during first visit Patient's impairment of both QI and YIN, blood pressure is between 100-160, and complexion Guang is yellow, dizzy, the numb unfavorable and constipation of side arm, leg.With with The course for the treatment of of 1 pill of the embodiment of the present invention one (is measured) for one month, plus dietotherapy conditioning is cloudy with tonifying Qi, and follow-up after two weeks, blood pressure is down to 90- 140, dizzy numbness makes moderate progress, further consultation after January, and dizzy, constipation disappears, and numbness is clearly better, and blood pressure is normal.One is taken again The course for the treatment of, blood pressure is normal, and numbness disappears, and blood fat is normal, continues to take course for the treatment of consolidation, follow-up after 1 year, blood pressure blood fat is normal.
Above-described is only the preferred embodiments of the present invention, and the explanation that should be understood that above example is to use Understand the method for the present invention and its core concept in help, the protection domain being not intended to limit the present invention is all the present invention's Any modification for being made within thought and principle, equivalent etc., should be included within the scope of the present invention.

Claims (4)

1. a kind of Chinese medicine preparation for treating cardiovascular and cerebrovascular disease, it is characterised in that be made up of the medicine of following weight：It is red 140~160 parts of ginseng, 95~105 parts of rhizoma Gastrodiae, 195~205 parts of pseudo-ginseng, 95~105 parts of hawthorn, 145~155 parts of American Ginseng, system is first 95~105 parts of crow, 145~155 parts of decumbent corydalis tuber, 45~55 parts of ground dragon protein, 45~55 parts of hirudin, snakegourd extract 15~25 Part, 5~25 parts of ginkgo biloba p.e, 5~25 parts of kudzu root extract, 5~25 parts of erigeron breviscapus extract.
2. a kind of Chinese medicine preparation for treating cardiovascular and cerebrovascular disease according to claim 1, it is characterised in that by following weight The medicine composition of part proportioning：150 grams of the red sage root, 100 grams of rhizoma Gastrodiae, 200 grams of pseudo-ginseng, 100 grams of hawthorn, 150 grams of American Ginseng, RADIX POLYGONI MULTIFLORI PREPARATA 100 grams, 150 grams of decumbent corydalis tuber, 50 grams of ground dragon protein, 50 grams of hirudin, 20 grams of snakegourd extract, 20 grams of ginkgo biloba p.e, Pueraria lobota 20 grams of root extract, 20 grams of erigeron breviscapus extract.
3. a kind of Chinese medicine preparation for treating cardiovascular and cerebrovascular disease according to claim 1 or 2, it is characterised in that：The Chinese juniper Building extract, ginkgo biloba p.e, kudzu root extract, erigeron breviscapus extract, which are, uses supercritical CO2Extracting process is obtained Extract.
4. a kind of Chinese medicine preparation for treating cardiovascular and cerebrovascular disease according to claim 1 or 2, it is characterised in that：In described Medicine preparation is pill.
CN201710233891.9A 2017-04-11 2017-04-11 A kind of Chinese medicine preparation for treating cardiovascular and cerebrovascular disease Pending CN106938048A (en)

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CN107496876A (en) * 2017-09-19 2017-12-22 韦家福 A kind of eliminating embolism and invigorating blood circulation Chinese medicine preparation and preparation method thereof
CN109420156A (en) * 2017-08-26 2019-03-05 杨振峰 A kind of drug of thrombolysis lipid-lowering row bolt

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Cited By (2)

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Publication number Priority date Publication date Assignee Title
CN109420156A (en) * 2017-08-26 2019-03-05 杨振峰 A kind of drug of thrombolysis lipid-lowering row bolt
CN107496876A (en) * 2017-09-19 2017-12-22 韦家福 A kind of eliminating embolism and invigorating blood circulation Chinese medicine preparation and preparation method thereof

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