CN104873685A - Medicine for treating coronary heart disease - Google Patents
Medicine for treating coronary heart disease Download PDFInfo
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- CN104873685A CN104873685A CN201510294034.0A CN201510294034A CN104873685A CN 104873685 A CN104873685 A CN 104873685A CN 201510294034 A CN201510294034 A CN 201510294034A CN 104873685 A CN104873685 A CN 104873685A
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Abstract
The invention provides medicine for treating coronary heart disease. The medicine comprises red ginseng, cassia twig, evodia, acorus tatarinowii, angelica sinensis, astragalus mongholicus, fructus choerospondiatis, semen ziziphi spinosae, sanders, dalbergia odorifera, ganoderma lucidum, prepared aconite root, rhizoma chuanxiong and prepared radix licorice. The components of the medicine are matched to warm yang and remove blood stasis and tonify the heart and soothe the nerves, and the medicine has evident curative effect on coronary heart disease, angina, myocardial ischemia, cardiac insufficiency (heart failure), vascular disease, cerebral arteriosclerosis and the like. The medicine is applicable to chest distress and palpitation, breath shortness and weakness, dyspnea, precordial pain, facial paralysis, unsmooth speech, limb inconvenience, memory deterioration, vascular intimal injury, heart and cerebral ischemia and hypoxia caused by thrombosis, heart function descent, brain infarction and the like. Clinical tests show that the medicine is quite good in coronary heart disease curative effect.
Description
Technical field
The invention belongs to technical field of Chinese medicines, be specifically related to a kind of Chinese medicine for the treatment of coronary heart disease.
Background technology
Coronary heart disease and coronary atherosclerotic heart disease (coronary artery heart disease, CHD), the traditional Chinese medical science claims " thoracic obstruction ", a kind of modal heart disease, refer to because coronary atherosclerosis makes coronary stricture, blood supply insufficiency and the myocardial dysfunction caused and (or) organic disease, therefore also known as ischemic cardiomyopathy (IHD).Be mainly in middle-aged and elderly people, suffer from the women of this disease more than male in China.The traditional Chinese medical science is thought, the pathogenesis of coronary heart disease is that heart arteries and veins is obstructed, how because blood stasis, expectorant are turbid, the stagnation of QI and causing, be again the result of long-term visceral dysfunction, often with heavy meal, catch cold, tired, direct stimulation is pathogenesis etiology.
Because Incidence of CHD is high, mortality rate is high, and the healthy of the mankind in serious harm, is referred to as " first killers of the mankind ".The medicament categories for the treatment of coronary heart disease is a lot, and great majority western medicine, cures the symptoms, not the disease.Its therapy approach, mainly with the medicine adopting coronary dilating and decreased heart rate, improves myocardial oxygen delivery and reduces myocardial oxygen consumption, thus alleviating state of an illness symptom.Facts have proved, though this kind of medicine can alleviate disease to a certain extent, there is impairment of YIN all the time, consumption gas, difficult Da Zhiben is sorry.Normally better during medication, just get back to the original state of an illness again once drug withdrawal, if inappropriate medication, also may fail to respond to any medical treatment and even increase the weight of disease.
Summary of the invention
The object of the invention is by tcm therapy, adopts traditional Chinese medical science wholistic therapy idea, plays the advantage that the traditional Chinese medical science is effected a permanent cure, and by adjusting the imbalance between YIN and YANG of whole body, accomplish blood circulation promoting and blood stasis dispelling, regulating QI to relieve pain, nourishing kidney is nourished heart, and QI invigorating is activated yang, thus fundamentally eliminates coronary heart disease.
Technical solution of the present invention is as follows, a kind of medicine for the treatment of coronary heart disease, and each crude drug component is by weight ratio: Radix Ginseng Rubra 15-30 part, Ramulus Cinnamomi 5-10 part, Fructus Evodiae 3-9 part, Rhizoma Acori Graminei 10-15 part, Radix Angelicae Sinensis 10-25 part, Radix Astragali 15-30 part, Fructus Choerospondiatis 2-5 part, Semen Ziziphi Spinosae 15-30 part, Lignum Santali Albi 2-5 part, Lignum Dalbergiae Odoriferae 10-15 part, Ganoderma 3-6 part, Radix Aconiti Lateralis Preparata 3-6 part, Rhizoma Chuanxiong 5-15 part, Radix Glycyrrhizae Preparata 3-6 part.
Medicine-feeding adds 500 milliliters, clear water, soaks 30 minutes, boils latter 30 minutes at a simmer, decoct 2 times, and merging medicinal liquid is 1 dose.One day 1 dose, point taking for 2 times, one month is a course for the treatment of.
Chinese medicine of the present invention can also preparation technology routinely, makes the acceptable any conventional dosage form of pharmaceutics, such as capsule, tablet, electuary, powder, soft capsule, drop pill or oral liquid etc.For enabling described dosage form realize, the acceptable adjuvant of pharmacy need be added when preparing these dosage forms, such as: filler, disintegrating agent, lubricant, suspending agent, binding agent, sweeting agent, correctives, antiseptic, substrate etc.Filler comprises: starch, pregelatinized Starch, lactose, mannitol, chitin, microcrystalline Cellulose, sucrose etc.; Disintegrating agent comprises: starch, pregelatinized Starch, microcrystalline Cellulose, carboxymethyl starch sodium, crospolyvinylpyrrolidone, low-substituted hydroxypropyl cellulose, cross-linking sodium carboxymethyl cellulose etc.; Lubricant comprises: magnesium stearate, sodium lauryl sulphate, Pulvis Talci, silicon dioxide etc.; Suspending agent comprises: polyvinylpyrrolidone, microcrystalline Cellulose, sucrose, agar, hydroxypropyl emthylcellulose etc.; Binding agent comprises, starch slurry, polyvinylpyrrolidone, hydroxypropyl emthylcellulose etc.; Sweeting agent comprises: saccharin sodium, Aspartane, sucrose, cyclamate, enoxolone etc.; Correctives comprises: sweeting agent and various essence; Antiseptic comprises: parabens, benzoic acid, sodium benzoate, sorbic acid and its esters, benzalkonium bromide, acetic acid chloroethene are fixed, Folium eucalypti globueli (Eucalyptus globulus Labill.) wet goods; Substrate comprises: PEG6000, PEG4000, insect wax etc.
The traditional Chinese medical science thinks that the heart is the dirty of Zhiyang, controlling blood and vessel, and department's mind take sun as this.Heart-yang fills, then unobstructed vessel, and blood circulation is without barrier; Ataraxia, then ascending or descending movement of vital Qi degree of having, the dirty biochemistry of internal organs is orderly.If heart-yang is impaired, blood is obstructed, stagnation of QI and blood may bring about pain, and the mind is lost peaceful, then arrhythmia; With the passing of time heart-yang exhaustion, water is wet to overflow.Then cardiac insufficiency.The all medicines of we match and play function of warming yang and gore removing altogether, the merit of heart tonifying and tranquilizing, have significant curative effect to diseases such as coronary heart diseases and angina pectoris, myocardial ischemia, cardiac insufficiency (heart failure), vascular lesion, cerebral arteriosclerosis.Be applicable to uncomfortable in chest nervous, shortness of breath and fatigue, dyspnea, precordialgia; Facial hemiparalysis, dysphonia, extremity inconvenience, hypomnesis; Blood vessel internal membrane damage, blood vessel embolism causes cardiac-cerebral ischemia anoxia, and cardiac function declines, the diseases such as cerebral infarction.Clinical trial proves, Drug therapy coronary heart disease curative effect of the present invention is rather good.Take medicine a course for the treatment of, symptom can obviously alleviate or disappear, and general about 90 days, can cure.Total effective rate more than 96.6%.
And the gentle easily clothes of the property of medicine of the present invention, after drug withdrawal not " bounce-back ", short treating period, instant effect, cure rate be high, have no side effect, safe and reliable.Modern pharmacology experimental result shows: medicine of the present invention has certain protective role to myocardial ischemia in rats caused by rat myocardium block caused by coronary ligation and pituitrin, acute myocardial infarction scope can be reduced, the serum creatine phosphokinase (CPK) suppressing myocardial ischemia and myocardial infarction to cause raises, and the change of rats with myocardial ischemia ECG ST section and T ripple can be alleviated, expansion dog heart arteria coronaria, increase coronary flow, reduce myocardial oxygen consumption, two-ways regulation blood pressure, two-ways regulation heart rate, increase cardiac output and reduce Peripheral resistance, improve mice hypoxia-bearing capability, strengthen mouse cardiac muscle to the picked-up of 86Rb, increase myocardial alimentary blood flow.No matter medicine contemporary toxicology research of the present invention, be acute toxinology experiment or long_term toxcity test, all have no adverse reaction.
The pharmacological effect of medicine of the present invention each component raw material medicine is as follows:
Radix Ginseng Rubra, nature and flavor: sweet, micro-hardship, temperature.Gui Jing: return spleen, lung, heart channel.Function cures mainly: strongly invigorating primordial QI, and multiple arteries and veins takes off admittedly, nourishing qi to stop.For weak body and prostration, cold extremities faint pulse, QI failing to control blood, metrostaxis; Heart failure, cardiogenic shock.
Ramulus Cinnamomi, acrid, sweet, warm.GUIXIN, lung, urinary bladder channel.Expelling cold and relieving exterior syndrome; Promoting the flow of QI-blood by warming the meridian; Activating YANG and prormoting functioning of QI.Main exterior syndrome due to wind-cold; Arthralgia due to cold-dampnes; Extreme cold of the limbs; Amenorrhea is suffered from abdominal pain; Lump in the abdomen lumps; The thoracic obstruction; Cardiopalmus; Dysuria.For anemofrigid cold, coldness and pain in the epigastrium, cold in blood amenorrhea, arthralgia, phlegm retention water-retention, edema, cardiopalmus, renal mass.
Fructus Evodiae, pungent, bitter, heat; Slightly poisonous.Return liver, spleen, stomach, kidney channel.Dispersing cold for relieving pain, stopping nausea and vomiting by lowering the adverse flow of QI, supporing yang antidiarrheal.For headache due to JUE YIN disorder, colic of cold type is suffered from abdominal pain, the disturbance of lower legs due to pathogenic cold and dampness, abdominal pain during menstruation, abdominal distention, vomiting acid regurgitation, Diarrhoea, external treatment aphtha; Hypertension.
Rhizoma Acori Graminei, acrid in the mouth, hardship, slightly warm in nature; GUIXIN, liver, spleen channel.Waking up the patient from unconsciousness by dissipating phlegm; Removing dampness circulation of qi promoting; To dispel the wind sharp numbness; Reducing swelling and alleviating pain.Main calentura coma; Syncope due to accumulation of phlegm; Forgetful; Tinnitus; Deaf; Abdominal distention; Fasting dysentery; Rheumatic arthralgia; Traumatic injury; Carbuncle scabies.
Radix Angelicae Sinensis, warm in nature, hide sweet, pungent.Return liver, the heart, spleen channel.Enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.Radix Angelicae Sinensis can improve hypercoagulability in body, and adjustment blood lipid metabolism, reduces cholesterol.
The Radix Astragali, property is sweet, tepor.Return lung, spleen, liver, kidney channel.There is effect that benefiting QI for strengthening the superficies, arresting sweating are admittedly de-, hold in the palm skin ulcer granulation promoting, inducing diuresis to remove edema.The Radix Astragali can strengthen myocardial contraction, coronary artery dilating, improves myocardial blood flow and myocardial metabolism, improves superoxide dismutase activity, lowers lipid peroxide contents, thus alleviates the damage that free radical causes.
Fructus Choerospondiatis, sweet, sour, flat.Promoting flow of QI and blood, nourishes heart, and calms the nerves.For qi depression to blood stasis, the thoracic obstruction is had a pain, shortness of breath and palpitation, irritability.
Semen Ziziphi Spinosae, sweet, flat.Gui Jing: heart channel; Spleen channel; Liver Channel; Gallbladder meridian.Function: mind tranquilizing and the heart calming; Nourishing the liver; Arresting sweating.Cure mainly: restlessness of asrhenia type and insomnia; Palpitation with fear palpitation with a distress feeling; Body empty spontaneous perspiration, night sweat.
Lignum Santali Albi, pungent, temperature.Return spleen, stomach, the heart, lung meridian.Circulation of qi promoting warming middle-JIAO, appetizing pain relieving.For QI stagnated by cold, chest pain, stomachache, stomachache lack of appetite; Coronary heart disease, angina pectoris.
Lignum Dalbergiae Odoriferae, pungent, temperature.Gui Jing: enter pericardium, Liver Channel.Function: clots absorbing hemostasis, reducing swelling and alleviating pain.Cure mainly: incised wound is hemorrhage, traumatic injury, pain, the diseases such as swelling and pain due to blood stasis.
Ganoderma, through a large amount of clinical research, Ganoderma is to the curative effect of the degree of having nothing in common with each other such as neurasthenia, hyperlipemia, angina pectoris, arrhythmia, Keshan disease, plateau uncomfortable disease, hepatitis, hemorrhagic fever, dyspepsia, tracheitis.
Radix Aconiti Lateralis Preparata, function cures mainly: recuperating depleted YANG and rescuing the patient from collapse, mend fire supporing yang, dispersing cold for relieving pain.Control excessive YIN keeping YANG externally, loss of YANG due to profuse perspiration, vomiting and diarrhea is fainted inverse, trusted subordinate's cold type of pain, the splenic diarrhea cold-dysentery, beriberi edema children's intermittent infantile convulsion, anemofrigid-damp arthralgia, the contracture of Wei lame, sexual impotence cold womb, the disease of the leakage of carbuncle of yin nature skin ulcer and all chronic diseaseses.
Rhizoma Chuanxiong, pungent, temperature.Return liver, gallbladder, pericardium channel.Blood-activating and qi-promoting, wind-expelling pain-stopping.For pacifying nerve, positive wind syndrome of head headache, lump in the abdomen is suffered from abdominal pain, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia.Rhizoma Chuanxiong can expand smooth muscle, improves microcirculation, and has anticoagulant, resistant to aggregation effect, and the blood pressure lowering by expansion peripheral vessel.
Radix Glycyrrhizae, property is put down, and sweet in the mouth, returns 12 warps.There is removing toxic substances, eliminate the phlegm, pain relieving, spasmolytic is so that the pharmacological action such as anticancer.Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.
Detailed description of the invention
Below by embodiment and test example, the invention will be further described.But the present invention is not limited to described in embodiment, those of ordinary skill in the art do some amendment, all in scope.
Embodiment 1. 1 kinds treats the medicine of coronary heart disease, and each crude drug component proportion is: Radix Ginseng Rubra 15 grams, Ramulus Cinnamomi 5 grams, Fructus Evodiae 3 grams, Rhizoma Acori Graminei 10 grams, Radix Angelicae Sinensis 10 grams, the Radix Astragali 15 grams, Fructus Choerospondiatis 2 grams, Semen Ziziphi Spinosae 15 grams, 2 grams, Lignum Santali Albi, Lignum Dalbergiae Odoriferae 10 grams, Ganoderma 3 grams, Radix Aconiti Lateralis Preparata 3 grams, Rhizoma Chuanxiong 5 grams, Radix Glycyrrhizae Preparata 3 grams.
Medicine-feeding adds 500 milliliters, clear water, soaks 30 minutes, boils latter 30 minutes at a simmer, decoct 2 times, and merging medicinal liquid is 1 dose.One day 1 dose, point taking for 2 times, 30 days is a course for the treatment of.
Embodiment 2. 1 kinds treats the medicine of coronary heart disease, and each crude drug component proportion is: Radix Ginseng Rubra 30 grams, Ramulus Cinnamomi 10 grams, Fructus Evodiae 9 grams, Rhizoma Acori Graminei 15 grams, Radix Angelicae Sinensis 25 grams, the Radix Astragali 30 grams, Fructus Choerospondiatis 5 grams, Semen Ziziphi Spinosae 30 grams, 5 grams, Lignum Santali Albi, Lignum Dalbergiae Odoriferae 15 grams, Ganoderma 6 grams, Radix Aconiti Lateralis Preparata 6 grams, Rhizoma Chuanxiong 15 grams, Radix Glycyrrhizae Preparata 6 grams.
Preparation and instructions of taking are with embodiment 1.
Embodiment 3. 1 kinds treats the medicine of coronary heart disease, and each crude drug component proportion is: Radix Ginseng Rubra 20 grams, Ramulus Cinnamomi 8 grams, Fructus Evodiae 6 grams, Rhizoma Acori Graminei 12 grams, Radix Angelicae Sinensis 15 grams, the Radix Astragali 20 grams, Fructus Choerospondiatis 4 grams, Semen Ziziphi Spinosae 20 grams, 4 grams, Lignum Santali Albi, Lignum Dalbergiae Odoriferae 12 grams, Ganoderma 5 grams, Radix Aconiti Lateralis Preparata 5 grams, Rhizoma Chuanxiong 10 grams, Radix Glycyrrhizae Preparata 5 grams.
Preparation and instructions of taking are with embodiment 1.
Embodiment 4. 1 kinds treats the medicine of coronary heart disease, and each crude drug component proportion is: Radix Ginseng Rubra 25 grams, Ramulus Cinnamomi 6 grams, Fructus Evodiae 8 grams, Rhizoma Acori Graminei 13 grams, Radix Angelicae Sinensis 12 grams, the Radix Astragali 25 grams, Fructus Choerospondiatis 4 grams, Semen Ziziphi Spinosae 20 grams, 4 grams, Lignum Santali Albi, Lignum Dalbergiae Odoriferae 14 grams, Ganoderma 4 grams, Radix Aconiti Lateralis Preparata 5 grams, Rhizoma Chuanxiong 11 grams, Radix Glycyrrhizae Preparata 4 grams.
Preparation and instructions of taking are with embodiment 1.
Embodiment 5. 1 kinds treats the medicine of coronary heart disease, and each crude drug component proportion is: Radix Ginseng Rubra 18 grams, Ramulus Cinnamomi 9 grams, Fructus Evodiae 7 grams, Rhizoma Acori Graminei 12 grams, Radix Angelicae Sinensis 21 grams, the Radix Astragali 25 grams, Fructus Choerospondiatis 4 grams, Semen Ziziphi Spinosae 28 grams, 5 grams, Lignum Santali Albi, Lignum Dalbergiae Odoriferae 14 grams, Ganoderma 6 grams, Radix Aconiti Lateralis Preparata 4 grams, Rhizoma Chuanxiong 12 grams, Radix Glycyrrhizae Preparata 5 grams.
Preparation and instructions of taking are with embodiment 1.
Model case
Case 1, patient Liu, female, 72 years old, coronary heart disease
Patient reaches 75% through hospital's arterial angiography diagnosis coronary stricture, ambulatory electrocardiogram display myocardial contraction declines, angina pectoris following exercise outbreak obviously, have palpitation, breathe hard, exception aroused in interest, be diagnosed as coronary heart disease middle and advanced stage, moderate heart failure, doctor advised prepares to implement cardiac stent operation in conjunction with clinical symptoms at any time, prevents acute myocardial infarction threat to life.Patient and family members consider that patient age is comparatively large, hold the misery that can't stand operation.So adopt Drug therapy of the present invention.After taking 3 months continuously, check display indices is tending towards normal, and symptom is obviously alleviated, and thoroughly avoids pain of surgery.Treatment artery radiography display: artery plaque volume reduces, and luminal stenosis drops to 60% by 75%, and blood supply recovers, the cardiac-cerebral ischemia remissions such as dizziness is weak, sensation of oppression over the chest with shortness of breath.Ambulatory electrocardiogram display myocardial contraction occurs ging up, ST section low pressure, and T ripple is inverted and is taken a turn for the worse, and heart failure is transferred to slightly by moderate, and angina pectoris seldom shows effect, and complexion is ruddy, from head to foot energetically.And the blood of patient is purified.Hemanalysis finds: the objectionable impurities content such as blood fat reduction, toxin, rubbish, heavy metal ion obviously reduce, and the morbidity root of coronary heart disease is blocked and controls, and avoids recurrence from root.
Case 2, patient Wang, man, 65 years old, coronary heart disease (hypertensive diabetes hyperlipidemia)
Patient suffers from coronary heart disease more than 10 year, also simultaneously with hypertension, and diabetes, hyperlipemia.The Chinese and western drugs attempted is many, but effect is as one wishes not to the utmost all the time, and often sense is uncomfortable in chest, and chest pain, tachypnea, sleeps bad.Lower limb are edema often.With feedback result Color Sonography after Drug therapy of the present invention: the broadening 36MM of ascending aorta internal diameter, interventricular septum and LVPW thicken 11MM, and Diastole Function goes down, and Left ventricular systolic function is normal.Take to pay a return visit after one month and just see just effect, symptom is obviously improved, and sleep good, edema occurs never again.After taking three months, outbreak uncomfortable in chest obviously reduces, and after adhering to taking half a year, angina pectoris disappears, and the indices such as blood fat, blood pressure, blood viscosity are all normal.
Claims (2)
1. treat a medicine for coronary heart disease, it is characterized in that, each crude drug component is by weight ratio: Radix Ginseng Rubra 15-30 part, Ramulus Cinnamomi 5-10 part, Fructus Evodiae 3-9 part, Rhizoma Acori Graminei 10-15 part, Radix Angelicae Sinensis 10-25 part, Radix Astragali 15-30 part, Fructus Choerospondiatis 2-5 part, Semen Ziziphi Spinosae 15-30 part, Lignum Santali Albi 2-5 part, Lignum Dalbergiae Odoriferae 10-15 part, Ganoderma 3-6 part, Radix Aconiti Lateralis Preparata 3-6 part, Rhizoma Chuanxiong 5-15 part, Radix Glycyrrhizae Preparata 3-6 part.
2. the medicine for the treatment of coronary heart disease according to claim 1, is characterized in that, each crude drug component is by weight ratio: Radix Ginseng Rubra 20 parts, Ramulus Cinnamomi 8 parts, Fructus Evodiae 6 parts, Rhizoma Acori Graminei 12 parts, Radix Angelicae Sinensis 15 parts, the Radix Astragali 20 parts, Fructus Choerospondiatis 4 parts, Semen Ziziphi Spinosae 20 parts, 4 parts, Lignum Santali Albi, Lignum Dalbergiae Odoriferae 12 parts, Ganoderma 5 parts, Radix Aconiti Lateralis Preparata 5 parts, Rhizoma Chuanxiong 10 parts, Radix Glycyrrhizae Preparata 5 parts.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105250861A (en) * | 2015-11-17 | 2016-01-20 | 山东省千佛山医院 | Compound preparation for treating coronary heart disease |
| CN112716992A (en) * | 2021-01-26 | 2021-04-30 | 山西晋康风湿病医院有限公司 | Traditional Chinese medicine composition for treating coronary heart disease and preparation method thereof |
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| CN1127126A (en) * | 1995-01-16 | 1996-07-24 | 张吉祥 | Traditional Chinese medicine for coronary heart disease and preparing method |
| CN104138515A (en) * | 2013-05-11 | 2014-11-12 | 哈尔滨济博生物技术开发有限公司 | Medicine for treating arrhythmia heart yang deficiency type coronary heart disease |
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2015
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Patent Citations (3)
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| CN104138515A (en) * | 2013-05-11 | 2014-11-12 | 哈尔滨济博生物技术开发有限公司 | Medicine for treating arrhythmia heart yang deficiency type coronary heart disease |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105250861A (en) * | 2015-11-17 | 2016-01-20 | 山东省千佛山医院 | Compound preparation for treating coronary heart disease |
| CN112716992A (en) * | 2021-01-26 | 2021-04-30 | 山西晋康风湿病医院有限公司 | Traditional Chinese medicine composition for treating coronary heart disease and preparation method thereof |
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